Rosanne D Reitsema, William F Jiemy, Lieske Wekema, Annemieke M H Boots, Peter Heeringa, Minke G Huitema, Wayel H Abdulahad, Yannick van Sleen, Maria Sandovici, Caroline Roozendaal, Arjan Diepstra, Thomas Kwee, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis S M van der Geest
Background: Although polymyalgia rheumatica (PMR) is a very common rheumatic inflammatory disease, current insight into the pathobiology of PMR is limited and largely based on studies in blood. We investigated T helper 1 (TH1 ) and T helper 17 (TH17 ) cell responses in blood, synovial fluid and bursa tissue of patients with PMR. Materials and methods: Blood samples were collected from 18 patients with new-onset PMR and 32 healthy controls. Synovial fluid was aspirated from the inflamed shoulder bursae or biceps tendon sheath of 13 patients...
2022: Frontiers in Immunology