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Yuwei Zhang, Zexing Cao, John Zenghui Zhang, Fei Xia
Construction of coarse-grained (CG) models for large biomolecules used for multiscale simulations demands a rigorous definition of CG sites for them. Several coarse-graining methods such as the simulated annealing and steepest descent (SASD) based on the essential dynamics coarse-graining (ED-CG) or the stepwise local iterative optimization (SLIO) based on the fluctuation maximization coarse-graining (FM-CG), were developed to do it. However, the practical applications of these methods such as SASD based on ED-CG are subject to limitations because they are too expensive...
February 9, 2017: Journal of Chemical Information and Modeling
A Sofia Silva, Ana M Sousa, Renato P Cabral, Marta C Silva, Clarinda Costa, Sónia P Miguel, Vasco D B Bonifácio, Teresa Casimiro, Ilídio J Correia, Ana Aguiar-Ricardo
Functionalized gold nanoparticles (AuNPs) have been widely investigated as promising multifunctional nanosystems for the theragnosis of lung cancer, the most common and prominent cause of cancer death worldwide. Nevertheless, nanoparticles are not in appropriate sizes for an accurate deep lung delivery and the lack of locally and effective delivery of therapeutic biomolecules to the deep lungs is, in fact, the major cause of low therapeutic outcome. Herein we incorporate, for the first time, AuNPs into respirable microparticles...
March 15, 2017: International Journal of Pharmaceutics
Iva Brabcová, Marie Trešlová, Sylva Bártlová, Jitka Vacková, Valerie Tóthová, Lenka Motlová
BACKGROUND AND AIM: Nutrition is an important social determinant of health that influences the ageing process. The aim of this study was to evaluate the nutritional condition of a group of seniors and identify the bio-psycho-social factors that increase the risk of malnutrition. METHODS: The research was conducted using a quantitative method. The standardised scales Mini Nutritional Assessment - Short Form (MNA-SF) and the Geriatric depression scale (GDS-5) were used to evaluate the nutritional condition and tendency towards depression of the tested group...
September 2016: Central European Journal of Public Health
Elise A Delagnes, Annick Aubin-Pouliot, Melissa Zheng, Jolie L Chang, William R Ryan
OBJECTIVES: To prospectively assess symptoms before and after sialendoscopy-assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis without sialolithiasis. STUDY DESIGN: Prospective cohort study. METHODS: Patients with chronic obstructive sialadenitis without sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS and 3 months postoperatively. RESULTS: Of 80 consecutive patients in a 20-month period, 20 surveyed patients underwent SASDS for COSWS in 37 symptomatic glands...
October 4, 2016: Laryngoscope
Joshua Matthew Allen Bullock, Jannik Schwab, Konstantinos Thalassinos, Maya Topf
Crosslinking mass spectrometry (XL-MS) is becoming an increasingly popular technique for modeling protein monomers and complexes. The distance restraints garnered from these experiments can be used alone or as part of an integrative modeling approach, incorporating data from many sources. However, modeling practices are varied and the difference in their usefulness is not clear. Here, we develop a new scoring procedure for models based on crosslink data-Matched and Nonaccessible Crosslink score (MNXL). We compare its performance with that of other commonly-used scoring functions (Number of Violations and Sum of Violation Distances) on a benchmark of 14 protein domains, each with 300 corresponding models (at various levels of quality) and associated, previously published, experimental crosslinks (XLdb)...
July 2016: Molecular & Cellular Proteomics: MCP
Annick Aubin-Pouliot, Elise A Delagnes, Jolie L Chang, William R Ryan
OBJECTIVES/HYPOTHESIS: To prospectively assess symptoms of obstructive sialadenitis before and after sialendoscopy-assisted salivary duct surgery (SASDS) using the chronic obstructive sialadenitis symptoms (COSS) questionnaire to determine and predict impact of interventions. STUDY DESIGN: Prospective cohort study. METHODS: Adult patients with chronic obstructive sialadenitis who underwent SASDS were asked to complete the COSS questionnaire and the Short-Form-8 (SF-8) quality-of-life (QOL) survey prior to surgery and 3 months postoperatively...
June 2016: Laryngoscope
Tao Wu, Hai Xin Song, Yan Dong, Jian Hua Li
OBJECTIVE: This systematic review and meta-analysis aimed to assess the effectiveness of ultrasound-guided (USG) versus blind (landmark-guided, LMG) corticosteroid subacromial-subdeltoid bursa injection in adults with shoulder pain. METHODS: The searches were performed on PubMed, Ovid MEDLINE, Ovid EMBASE, Ovid CochraneCENTRAL, Web of Science, Google Scholar, and Scopus from database inception through March 27, 2015. Studies were included trials comparing USG versus LSG injections for the treatment of adults with subacromial-subdeltoid bursitis...
December 2015: Seminars in Arthritis and Rheumatism
Shay Bess, Breton Line, Kai-Ming Fu, Ian McCarthy, Virgine Lafage, Frank Schwab, Christopher Shaffrey, Christopher Ames, Behrooz Akbarnia, Han Jo, Michael Kelly, Douglas Burton, Robert Hart, Eric Klineberg, Khaled Kebaish, Richard Hostin, Gregory Mundis, Praveen Mummaneni, Justin S Smith
STUDY DESIGN: A retrospective analysis of a prospective, multicenter database. OBJECTIVE: The aim of this study was to evaluate the health impact of symptomatic adult spinal deformity (SASD) by comparing Standard Form Version 2 (SF-36) scores for SASD with United States normative and chronic disease values. SUMMARY OF BACKGROUND DATA: Recent data have identified radiographic parameters correlating with poor health-related quality of life for SASD...
February 2016: Spine
Annick Aubin-Pouliot, Elise A Delagnes, David W Eisele, Jolie L Chang, William R Ryan
OBJECTIVES/HYPOTHESIS: Introduce the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire to quantify chronic sialadenitis symptoms and assess the impact of sialendoscopic-assisted salivary duct surgery (SASDS). STUDY DESIGN: Retrospective outcome symptoms questionnaire study. METHODS: The COSS questionnaire assesses the severity of sialadenitis symptoms from 0 to 100. Patients who underwent SASDS from April 2006 to December 2013 completed the COSS questionnaire and the ShortForm8 Health Survey (SF-8) based on current symptoms, and reported whether they had complete, partial, or no symptomatic response to SASDS...
January 2016: Laryngoscope
Ferdinando Draghi, Luigia Scudeller, Anna Guja Draghi, Chandra Bortolotto
PURPOSE: The presence of the subacromial-subdeltoid (SASD) bursa inflammation has recently been proposed as a primary radiologic factor predicting persistent limitation and pain in operated patients. The aim of the study was to verify the hypothesis that pain, or increased shoulder pain, could be associated with SASD bursitis not only in operated patients but also in general population. METHODS: A consecutive series of 1940 shoulder ultrasound examinations were performed by our Department over a 5-year period using linear multi-frequency probes...
June 2015: Journal of Ultrasound
Kamyar Vaziri, Darius M Moshfeghi, Tina Hernandez-Boussard, Natalia F Callaway, Andrew A Moshfeghi
BACKGROUND AND OBJECTIVE: To evaluate the utilization rates of ambulatory surgery centers (ASCs) in the state of Florida for vitreoretinal, cataract, and glaucoma surgical procedures over a 13-year period from 1999 through 2011. PATIENTS AND METHODS: Retrospective analysis utilizing the State Ambulatory Surgery Databases (SASD) for Florida from 1999 through 2011. ICD-9 codes for vitreoretinal, cataract, and glaucoma procedures were queried. Joinpoint regression was used to calculate average annual percent change (APC) in ASC utilization by these procedures over the 13-year study period and also separately for the years 2007 to 2011...
March 2015: Ophthalmic Surgery, Lasers & Imaging Retina
Wonkyung Cho, Min-Soo Kim, Min-Sook Jung, Junsung Park, Kwang-Ho Cha, Jeong-Soo Kim, Hee Jun Park, Amjad Alhalaweh, Sitaram P Velaga, Sung-Joo Hwang
The overall aim of this study was to prepare a nasal powder formulation of salmon calcitonin (sCT) using an absorption enhancer to improve its bioavailability. In this work, powder formulations for nasal delivery of sCT were studied using various absorption enhancers and stabilizers. Powders were prepared by two different methods: conventional spray-drying (SD) and novel supercritical fluid-assisted spray-drying (SASD) to investigate the role of CO2 in the particle formation process. The prepared sCT powder formulations were characterized by several analyses; powder X-ray diffractometry (PXRD), scanning electron microscopy (SEM), and the Fourier transform infrared (FT-IR) spectroscopy method...
January 15, 2015: International Journal of Pharmaceutics
Valérie Tóthová, Sylva Bártlová, František Dolák, Jiří Kaas, David Kimmer, Jana Maňhalová, Lukáš Martinek, Věra Olišarová
OBJECTIVES: A quality of life assessment is of great importance for patients with chronic diseases, because problems caused by specific diseases impact specific areas of their lives. The goal of this work was to determine, in which areas select diseases (rheumatoid arthritis, Crohn's disease, ischemic disease of the lower extremities and chronic obstructive pulmonary disease) affect patients' quality of life. METHODS: The Czech version of the WHOQOL-100 instrument and specific standardized questionnaires for individual diseases: EuroQol, EQ-5D-5L, IBDQ, PAQ were used to assess quality of life...
2014: Neuro Endocrinology Letters
Gianluca Rigatelli, Fabio Dell'avvocata, Giuseppe Tarantini, Massimo Giordan, Paolo Cardaioli, Thach Nguyen
BACKGROUND: Paradoxical embolism associated with secundum atrial septal defect (sASD) is a relatively rare but well-known occurrence. The purpose of our study is to report the clinical, hemodynamic, and anatomical features assessed by intracardiac echocardiography (ICE) of sASD as related to paradoxical embolism. METHODS: Five hundred thirty-seven patients (mean age 48 ± 19.0 years) admitted for transcatheter repair of interatrial shunts were enrolled in a prospective registry over a 10-year period (September 2003-September 2013)...
December 2014: Journal of Interventional Cardiology
Ilana Wainer, Luciana Figueiredo Prado, Myriam Khodri, Bette Otto-Bliesner
Climate indices based on sea surface temperature (SST) can synthesize information related to physical processes that describe change and variability in continental precipitation from floods to droughts. The South Atlantic Subtropical Dipole index (SASD) is based on the distribution of SST in the South Atlantic and fits these criteria. It represents the dominant mode of variability of SST in the South Atlantic, which is modulated by changes in the position and intensity of the South Atlantic Subtropical High...
2014: Scientific Reports
Nathaniel Bell, Boris Sobolev, Stephen Anderson, Robert Hewko, Richard K Simons
BACKGROUND: Screening for acute stress is not part of routine trauma care owing in part to high variability of acute stress symptoms in identifying later onset of posttraumatic stress disorder (PTSD). The objective of this pilot study was to assess the sensitivity, specificity, and power to predict onset of PTSD symptoms at 1 and 4 months using a routine screening program in comparison to current ad hoc referral practice. METHODS: Prospective cross-sectional observational study of a sample of hospitalized trauma patients over a four-month period from a level-I hospital in Canada...
2014: Journal of Trauma Management & Outcomes
K Bekelis, S Missios, C Eskey, N Labropoulos
AIMS: Several groups have demonstrated the safety of ambulatory cerebral angiography, with no patients experiencing complications related to early discharge. Although this practice appears to be safe, the socioeconomic characteristics factoring in the selection of the patients have not been investigated. METHODS: We performed a retrospective cohort study involving 45,226 patients undergoing outpatient and 159,046 undergoing inpatient cerebral angiography, who were registered in the State Ambulatory Surgery Databases (SASD) and State Inpatient Databases (SID) respectively for 4 US States (New York, California, Florida, North Carolina)...
February 2014: International Angiology: a Journal of the International Union of Angiology
Kimon Bekelis, Symeon Missios, George Kakoulides, Redi Rahmani, Nathan Simmons
BACKGROUND CONTEXT: There is a persistent trend for more outpatient lumbar discectomies in the United States. PURPOSE: To investigate the characteristics of the patients selected for ambulatory procedures. STUDY DESIGN: Retrospective cohort study. PATIENT SAMPLE: Forty-seven thousand one hundred twenty-five patients who underwent outpatient and 102,592 patients undergoing inpatient lumbar discectomies and were were registered in the State Ambulatory Surgery Database (SASD) and State Inpatient Database (SID), respectively, for New York, California, Florida, and North Carolina from 2005 to 2008...
September 1, 2014: Spine Journal: Official Journal of the North American Spine Society
Fan Zhang, Renee Drabier
BACKGROUND: Alternative splicing is an important and widespread mechanism for generating protein diversity and regulating protein expression. High-throughput identification and analysis of alternative splicing in the protein level has more advantages than in the mRNA level. The combination of alternative splicing database and tandem mass spectrometry provides a powerful technique for identification, analysis and characterization of potential novel alternative splicing protein isoforms from proteomics...
2013: BMC Bioinformatics
Kimon Bekelis, Symeon Missios, David W Roberts
Several groups have demonstrated the safety of ambulatory brain biopsies, with no patients experiencing complications related to early discharge. Although they appear to be safe, the reasons factoring into the selection of patients have not been investigated. We performed a cross-sectional study involving 504 patients who underwent outpatient and 10,328 patients who underwent inpatient brain biopsies and were registered in State Ambulatory Surgery Databases and State Inpatient Databases respectively for four US States (New York, California, Florida, North Carolina)...
November 2013: Journal of Neuro-oncology
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