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Cognitive stimulation in dementia

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https://www.readbyqxmd.com/read/29781725/the-effects-of-an-expanded-cognitive-stimulation-therapy-model-on-the-improvement-of-cognitive-ability-of-elderly-with-mild-stage-dementia-living-in-a-community-a-randomized-waitlist-controlled-trial
#1
Daniel Kim-Wan Young, Petrus Yat-Nam Ng, Timothy Kwok, Florence Ho, Daphne Cheng, Vivan Mak, Andrew Lau
OBJECTIVE: This research study aims to evaluate the effectiveness of an expanded cognitive stimulation therapy (CST) model that combines a CST group and tai chi on improving the cognitive ability of community-dwelling Chinese elderly with mild stage dementia (EwMD). METHOD: A randomized waitlist controlled trial design was adopted in this study. The treatment group participated in a structured CST group followed by tai chi twice a week, with a total of 14 sessions throughout the study period...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29752032/knowledge-and-beliefs-about-dementia-among-the-general-public-a-preliminary-report-on-the-cuban-population
#2
Y Broche-Pérez, Z Fernández-Fleites, B González, M A Hernández Pérez, Y I Salazar-Guerra
BACKGROUND: The number of people diagnosed with dementia globally has dramatically increased in recent years. The objective of this study was to explore beliefs and knowledge among the Cuban population with regard to the risk factors that may lead to dementia and the actions that may be taken to prevent it. METHOD: In an exploratory cross-sectional study, we surveyed a total of 391 people aged between 18 and 96 years. The results were stratified by sex, age range, level of education, and contact with dementia...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29736590/anatomical-predictors-of-cognitive-decline-after-subthalamic-stimulation-in-parkinson-s-disease
#3
Vincent Planche, Fanny Munsch, Bruno Pereira, Emmanuel de Schlichting, Tiphaine Vidal, Jerome Coste, Dominique Morand, Ingrid de Chazeron, Philippe Derost, Bérangère Debilly, Pierre-Michel Llorca, Jean-Jacques Lemaire, Ana Marques, Franck Durif
We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who underwent bilateral STN-DBS. Normalized brain structure volumes and cortical thicknesses were measured on pre-operative T1-weighted MRI. Patients were tested for their cognitive performances before surgery and 1 year after...
May 7, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29717527/cultural-adaptation-of-cognitive-stimulation-therapy-cst-for-chinese-people-with-dementia-multicentre-pilot-study
#4
Gloria H Y Wong, Olive P L Yek, Anna Y Zhang, Terry Y S Lum, Aimee Spector
OBJECTIVE: Ageing of the Chinese population will drive a continued surge in dementia prevalence. Empirically tested non-pharmacological interventions developed in western cultures may be implemented in Chinese. Cognitive Stimulation Therapy (CST) that originated in the UK has proven benefits on cognition and quality of life in people with dementia. We investigated the feasibility and cultural appropriateness of CST in Hong Kong Chinese (CST-HK). METHODS: Mixed methods research was conducted following the formative method for adapting psychotherapy...
June 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29706882/cognitive-function-and-brain-atrophy-predict-non-pharmacological-efficacy-in-dementia-the-mihama-kiho-scan-project2
#5
Ken-Ichi Tabei, Masayuki Satoh, Jun-Ichi Ogawa, Tomoko Tokita, Noriko Nakaguchi, Koji Nakao, Hirotaka Kida, Hidekazu Tomimoto
We aimed to determine whether neuropsychological deficits and brain atrophy could predict the efficacy of non-pharmacological interventions. Forty-six participants with mild-to-moderate dementia were monitored for 6 months; 25 underwent an intervention involving physical exercise with music, and 21 performed cognitive stimulation tasks. Participants were categorized into improvement (IMP) and no-IMP subgroups. In the exercise-with-music group, the no-IMP subgroup performed worse than the IMP subgroup on the Rivermead Behavioural Memory Test at baseline...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29663065/-individual-activation-of-dementia-sufferers-in-a-home-setting-a-randomized-controlled-study
#6
Renate Stemmer, Elmar Gräßel, Martin Schmid
BACKGROUND AND OBJECTIVES: The present project investigated the hypothesis that a multimodal individual activation of people with mild to moderate dementia in the home setting during a 6-month intervention period leads to improved everyday practice and cognitive abilities compared to the control group. MATERIAL AND METHODS: Intervention: a practical activation was performed by relatives 6 days per week. Cognitive stimulation took place once a week and was done by an external person...
April 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29661060/mental-work-demands-and-late-life-cognitive-impairment-results-from-the-shanghai-aging-study
#7
Xiaoniu Liang, Zhao Chen, Xinqi Dong, Qianhua Zhao, Qihao Guo, Li Zheng, Wei Deng, Jianfeng Luo, Ding Ding
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < ...
April 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29650692/microrna-mediated-therapy-modulating-blood-brain-barrier-disruption-improves-vascular-cognitive-impairment
#8
Kensuke Toyama, Joshua M Spin, Alicia C Deng, Ting-Ting Huang, Ke Wei, Markus U Wagenhäuser, Takuya Yoshino, Huy Nguyen, Joscha Mulorz, Soumajit Kundu, Uwe Raaz, Matti Adam, Isabel N Schellinger, Ann Jagger, Philip S Tsao
OBJECTIVE: There are currently no effective treatments for the prevention of dementia associated with vascular cognitive impairment. MicroRNAs regulate gene expression at the post-transcriptional level and play key roles in vascular disorders. TNFα (tumor necrosis factor-α) regulates blood-brain barrier breakdown through modification of cerebral tight junctions. Here, we sought key TNFα-responsive microRNAs that might influence blood-brain barrier breakdown via cerebral tight junction disruption in vascular cognitive impairment...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29642850/using-observational-facial-descriptors-to-infer-pain-in-persons-with-and-without-dementia
#9
Stefan Lautenbacher, Anna Lena Walz, Miriam Kunz
BACKGROUND: For patients with advanced dementia, pain diagnosis and assessment requires observations of pain-indicative behavior by others. One type of behavior that has been shown to be a promising candidate is the facial response to pain. To further test how pain-indicative facial responses are, we investigated the predictive power of observational facial descriptors to (i) predict the self-report of pain and (ii) to differentiate between non-painful and painful conditions. In addition, the expertise of the observers (nurses vs...
April 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29608782/one-year-effect-of-the-medicare-annual-wellness-visit-on-detection-of-cognitive-impairment-a-cohort-study
#10
Nicole R Fowler, Noll L Campbell, Gerhardt M Pohl, Leanne M Munsie, Noam Y Kirson, Urvi Desai, Erich J Trieschman, Mark K Meiselbach, J Scott Andrews, Malaz A Boustani
OBJECTIVES: To examine the effect of the Medicare Annual Wellness Visit (AWV) on the detection of cognitive impairment and on follow-up cognitive care for older adults. DESIGN: Retrospective matched-cohort study. SETTING: United States. PARTICIPANTS: A 5% random sample of fee-for-service Medicare beneficiaries continuously enrolled for 12 months before and after an index ambulatory visit occurring from 2011 to 2013 with no claims evidence of cognitive impairment before index...
April 2, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29598932/glucagon-like-peptide-1-glp-1-likes-alzheimer-s-disease
#11
REVIEW
Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkalp
Glucagon-like peptide-1 (GLP-1) is a 30 amino acid long peptide hormone derived from the proglucagon gene and secreted in the distal small intestine when food enters the duodenum. GLP-1 is also produced in the central nervous system (CNS), predominantly in the brainstem, and subsequently transported to a large number of regions in the CNS. Neuronal cells in nucleus tractus solitarius (NTS) can synthesize GLP-1 and extends to hypothalamus, some thalamic and cortical areas. A G protein coupled receptor (GPCR) provides the majority of GLP-1 actions...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29572105/-behavioral-and-psychological-symptoms-of-dementia-bpsd-and-impaired-cognition-reflect-unsuccessful-neuronal-compensation-in-the-pre-plaque-stage-and-serve-as-early-markers-for-alzheimer-s-disease-in-the-app23-mouse-model
#12
Anna Pfeffer, Tonia Munder, Stefanie Schreyer, Charlotte Klein, Justyna Rasińska, York Winter, Barbara Steiner
Recent research on Alzheimer's disease (AD) focuses on processes prior to amyloid-beta plaque deposition accounting for the progress of the disease. However, early mechanisms of AD are still poorly understood and predictors of the disease in the pre-plaque stage essential for initiating an early therapy are lacking. Behavioral and psychological symptoms of dementia (BPSD) and potentially impaired cognition may serve as predictors and early clinical diagnostic markers for AD. To investigate potential BPSD and cognitive impairments in association with neuronal cell development as such markers for AD in the pre-plaque stage, female APP23 mice at eight, 19 and 31 weeks of age and corresponding control animals were tested for BPSD (elevated zero maze; sucrose preference test), motor coordination (rotarod), spatial memory and reversal learning (Morris water maze) and hippocampal neurogenesis as a neuronal correlate for hippocampus-dependent behavior...
March 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29568856/approach-to-the-forgetful-patient
#13
Peng Soon Yoon, Chun How Ooi, Choon How How
Singapore has an ageing population with a projected 53,000 people aged ≥ 60 years living with dementia by 2020. Primary care doctors have the opportunity to initiate early work-up for reversible causes of cognitive dysfunction, allowing identification of comorbidities and discussion of medical therapy options. Early diagnosis confers the sick role on the patient, which allays frustration and explains events and behaviour that may have strained relationships with family and friends. The patient can be encouraged to plan for future health and personal care options with a Lasting Power of Attorney and/or Advance Care Planning...
March 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29559782/repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-cognitive-impairment-in-frontotemporal-dementia-an-open-label-pilot-study
#14
Jakub Antczak, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Barbara Wach, Katarzyna Kasprzyk, Marta Banach, Karolina Rzeźnicka-Brzegowy, Jadwiga Kubica, Agnieszka Słowik
Background: Frontotemporal dementia (FTD) is one of the most frequent dementia types in patients under 65 years of age. Currently, no therapy can effectively improve the cognitive deficits associated with FTD. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method of inducing brain plasticity with therapeutic potential in neurodegenerative diseases. The purpose of this study was to evaluate the effect of rTMS on cognitive, behavioral, and emotional function in FTD...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29558564/systems-approaches-to-optimizing-deep-brain-stimulation-therapies-in-parkinson-s-disease
#15
REVIEW
Sabato Santaniello, John T Gale, Sridevi V Sarma
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological diseases like dystonia, obsessive-compulsive disorders, essential tremor, Parkinson's disease, and more recently, dementias, depression, cognitive disorders, and epilepsy. Despite its wide use, DBS presents numerous challenges for both clinicians and engineers. One challenge is the design of novel, more efficient DBS therapies, which are hampered by the lack of complete understanding about the cellular mechanisms of therapeutic DBS...
March 20, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29554196/speech-language-pathologist-interventions-for-communication-in-moderate-severe-dementia-a-systematic-review
#16
Katina Swan, Marie Hopper, Rachel Wenke, Claire Jackson, Tracy Till, Erin Conway
Purpose: The purpose of this study is to evaluate the evidence for direct and indirect interventions for communication in people with moderate-severe dementia. Method: A systematic search of the literature was conducted, as per the Preferred Reporting Items for Systematic Reviews and Meta-Analysed guidelines, across 8 electronic databases. Studies were included if they included direct or indirect interventions, which could be administered by a speech-language pathologist to people with moderate-severe dementia (defined as having Mini-Mental State Examination of ≤ 15; Folstein, Folstein, & McHugh, 1975)...
March 19, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29545211/ling-yang-gou-teng-decoction-prevents-vascular-dementia-through-inhibiting-oxidative-stress-induced-neurovascular-coupling-dysfunction
#17
Xin Zhao, Jinyu Liu, Shijun Yang, Dandan Song, Chen Wang, Chen Chen, Xiaoya Li, Qiuting Wang, Shasha Ge, Runmei Yang, Xiuhua Liu, Yulin Lin, Dayong Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Vascular dementia (VaD) is the common cognitive disorder derived mainly from lacunar stroke (LS). The oxidative stress induced neurovascular coupling (NVC) dysfunction involves in the pathogenesis of VaD. Currently, there is no specific drug for VaD. Ling-Yang-Gou-Teng -Decoction (LG), a well-known traditional Chinese formula, has been used for preventing VaD in clinic. AIM OF THE STUDY: In this study, we aimed to investigate the underlying mechanism of LG on VaD in rats...
March 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29538492/analysis-of-the-linguistic-profile-in-down-syndrome-using-the-arizona-battery-for-communication-disorders-of-dementia-a-pilot-study
#18
COMPARATIVE STUDY
Cláudia Lopes Carvalho, Ariella Fornachari Ribeiro Belan, Leila Regina de Castro, Márcia Radanovic
PURPOSE: To characterize the linguistic profile of adults and elderly with Down Syndrome (DS) using the Arizona Battery for Communication Disorders of Dementia (ABCD). METHODS: Thirty adult individuals with DS were evaluated through the MoCA cognitive battery, four functional scales (Pfeffer, Lawton-IADL, Katz-IADL and IQCODE) and the ABCD battery, which evaluates Mental State, Episodic Memory, Linguistic Expression, Linguistic Comprehension and Visuospatial Construction...
March 12, 2018: CoDAS
https://www.readbyqxmd.com/read/29528689/a-cost-effectiveness-analysis-of-maintenance-cognitive-stimulation-therapy-mcst-for-people-with-dementia-examining-the-influence-of-cognitive-ability-and-living-arrangements
#19
Heather Brown, Francesco D'Amico, Martin Knapp, Martin Orrell, Amritpal Rehill, Luke Vale, Louise Robinson
OBJECTIVES: Identify if cost-effectiveness of Maintenance Cognitive Simulation Therapy (MCST) differs by type of living arrangement and cognitive ability of the person with dementia. Next, a value of information analysis is performed to inform decisions about future research. METHODS: Incremental cost-effectiveness analysis applying seemingly unrelated regressions using data from a multicentre RCT of MCST versus treatment as usual in a population which had already received 7 weeks of CST for dementia (ISRCTN: 26286067)...
March 12, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29526715/a-novel-pharmacodynamic-model-in-rats-for-preventing-vascular-dementia-from-maintaining-neurovascular-coupling-sensitivity
#20
Xin Zhao, Jinyu Liu, Shijun Yang, Dandan Song, Chen Wang, Chen Chen, Chengcheng Wang, Feifei Pu, Runmei Yang, Xiaoya Li, Qiuting Wang, Shasha Ge, Yulin Lin, Xiuhua Liu, Dayong Cai
Vascular dementia (VaD) is the common cognitive disorder derived mainly from lacunar stroke. The neurovascular coupling (NVC) dysfunction involves in its pathogenesis. VaD lacks suitable animal models for developing preventive therapies. This study aimed to confirm a model for preventing VaD via maintaining NVC sensitivity in rats. The model was replicated with autologous microthrombi against the background of hypercholesterolemia. A phosphodiesterase inhibitor (pentoxyfylline) was preventively administrated to confirm the role of NVC sensitivity...
May 15, 2018: European Journal of Pharmacology
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