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Cognitive stimulation in dementia

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https://www.readbyqxmd.com/read/28202615/il-13-mediated-regulation-of-learning-and-memory
#1
Tiroyaone M Brombacher, Justin K Nono, Keisha S De Gouveia, Nokuthula Makena, Matthew Darby, Jacqueline Womersley, Ousman Tamgue, Frank Brombacher
The role of proinflammatory cytokines in cognitive function has been investigated with both beneficial and possible detrimental effects, depending on the cytokine. More recently, the type 2 IL-4 has been demonstrated to play a role in cognition. In this study, using the Morris water maze task, we demonstrate that IL-13-deficient mice are significantly impaired in working memory as well as attenuated reference memory, both functions essential for effective complex learning. During the learning process, wild-type mice increased the number of CD4(+) T cells in the meninges and production of IL-13, whereas neither Morris water maze-trained IL-4 nor trained IL-13-deficient mice were able to increase CD4(+) T cells in the meninges...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28183245/ykl-40-as-a-potential-biomarker-and-a-possible-target-in-therapeutic-strategies-of-alzheimer-s-disease
#2
Paweł Muszyński, Magdalena Groblewska, Agnieszka Kulczyńska-Przybik, Alina Kułakowska, Barbara Mroczko
BACKGROUND: Growing body of evidence suggests that pathogenesis of Alzheimer's disease (AD), a progressing neurodegenerative condition, is not limited to the neuronal compartment, but also involves various immunological mechanisms. Insoluble Aβ aggregates in the brain can induce the activation of microglia, resulting in synthesis of proinflammatory mediators, which further can stimulate astrocytic expression of YKL-40. Therefore, the aim of the current review is to present up-to-date data about the role of YKL-40 as a biomarker of AD as well as the possibility of therapeutic strategies targeting neuroinflammation...
February 8, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28149509/music-therapy-is-a-potential-intervention-for-cognition-of-alzheimer-s-disease-a-mini-review
#3
REVIEW
Rong Fang, Shengxuan Ye, Jiangtao Huangfu, David P Calimag
Alzheimer's Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (MT) is a non-pharmacological way with a long history of use and a fine usability for dementia patients. In this review, we will summarize different techniques, diverse clinical trials, and the mechanisms of MT as it is helpful to the cognition in AD, providing reference for future research. Many articles have demonstrated that MT can reduce cognitive decline especially in autobiographical and episodic memories, psychomotor speed, executive function domains, and global cognition...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28144880/use-of-stimulants-in-bipolar-disorder
#4
REVIEW
Giulio Perugi, Giulia Vannucchi, Fulvio Bedani, Ettore Favaretto
Several international guidelines indicate stimulants, including methylphenidate (MPH), amphetamines and derivatives, modafinil, and armodafinil among the second-third-line choices for bipolar depression. Efficacy of stimulants has been also reported for the management of residual depressive symptoms such as fatigue and sleepiness and for the management of affective, cognitive, and behavioral symptoms in children and adult bipolar patients with comorbid ADHD. Few case reports show positive results with MPH in the treatment of resistant mania...
January 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28137833/the-impact-of-bilingualism-on-brain-reserve-and-metabolic-connectivity-in-alzheimer-s-dementia
#5
Daniela Perani, Mohsen Farsad, Tommaso Ballarini, Francesca Lubian, Maura Malpetti, Alessandro Fracchetti, Giuseppe Magnani, Albert March, Jubin Abutalebi
Cognitive reserve (CR) prevents cognitive decline and delays neurodegeneration. Recent epidemiological evidence suggests that lifelong bilingualism may act as CR delaying the onset of dementia by ∼4.5 y. Much controversy surrounds the issue of bilingualism and its putative neuroprotective effects. We studied brain metabolism, a direct index of synaptic function and density, and neural connectivity to shed light on the effects of bilingualism in vivo in Alzheimer's dementia (AD). Eighty-five patients with probable AD and matched for disease duration (45 German-Italian bilingual speakers and 40 monolingual speakers) were included...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28122429/suspected-perinatal-depression-revealed-to-be-hereditary-diffuse-leukoencephalopathy-with-spheroids
#6
Josefine Blume, Robert Weissert
Early motor symptoms of neurodegenerative diseases often appear in combination with psychiatric symptoms, such as depression or personality changes, and are in danger of being misdiagnosed as psychogenic in young patients. We present the case of a 32-year-old woman who presented with rapid-onset depression, followed by a hypokinetic movement disorder and cognitive decline during pregnancy. Genetic testing revealed a mutation in the colony-stimulating factor 1 receptor gene, which led to the diagnosis of hereditary diffuse leukoencephalopathy with spheroids...
January 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28113102/key-clinical-milestones-15-years-and-onwards-after-dbs-stn-surgery-a-retrospective-analysis-of-patients-that-underwent-surgery-between-1993-and-2001
#7
Radu Constantinescu, Barbro Eriksson, Yvonne Jansson, Bo Johnels, Björn Holmberg, Thordis Gudmundsdottir, Annika Renck, Peter Berglund, Filip Bergquist
OBJECTIVE: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for motor fluctuations in Parkinson's disease (PD), but does not halt disease progression. The long-term deterioration of key functions such as cognition, speech, ability to swallow, gait, urinary bladder control, orientation and reality perception is decisive for patients' independency in daily life. In this paper we investigated patients with advanced PD operated at our center with STN-DBS for at least 15 years ago, in respect to key clinical milestones reflecting their overall function in daily living...
January 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28112412/staff-training-and-outreach-support-for-cognitive-stimulation-therapy-and-its-implementation-in-practice-a-cluster-randomised-trial
#8
Amy Streater, Aimee Spector, Zoe Hoare, Elisa Aguirre, Ian Russell, Martin Orrell
OBJECTIVE: There is evidence that Cognitive Stimulation Therapy and maintenance Cognitive Stimulation Therapy are effective in mild to moderate dementia. There is, however, little evidence available for its implementation in practice and the impact of outreach support on the sustainability of the programme. METHODS: Two hundred and forty-one staff members were randomised from 63 dementia care settings between outreach support including an online forum, email, and telephone support, compared to usual Cognitive Stimulation Therapy control group...
January 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28068146/a-natural-language-based-presentation-of-cognitive-stimulation-to-people-with-dementia-in-assistive-technology-a-pilot-study
#9
Nina Dethlefs, Maarten Milders, Heriberto Cuayáhuitl, Turkey Al-Salkini, Lorraine Douglas
Currently, an estimated 36 million people worldwide are affected by Alzheimer's disease or related dementias. In the absence of a cure, non-pharmacological interventions, such as cognitive stimulation, which slow down the rate of deterioration can benefit people with dementia and their caregivers. Such interventions have shown to improve well-being and slow down the rate of cognitive decline. It has further been shown that cognitive stimulation in interaction with a computer is as effective as with a human...
January 9, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28012594/senses-make-sense-an-individualized-multisensory-stimulation-for-dementia
#10
Yuanwu Cui, Minxue Shen, Yan Ma, Shi Wu Wen
Nonpharmacologic interventions have been recommended as first-line treatments for dementia, and multisensory stimulation environment has been used as a non-pharmacological treatment to dementia patients in the last decade. However, the clinical effect of multisensory stimulation environment remains temporary and uncertain. Individualized medicine has been suggested to hold great promise in medicine, and it should be equally important for dementia. Reminiscence integrating individual experiences into therapeutic schemes has shown potential in the field of improving cognitive functions and depressive symptoms for dementia patients, and interactive music also demonstrated a positive outcome by using individualized music for the hearing aspect...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/27989773/in-vivo-detection-of-microstructural-correlates-of-brain-pathology-in-preclinical-and-early-alzheimer-disease-with-magnetic-resonance-imaging
#11
Yue Zhao, Marcus E Raichle, Jie Wen, Tammie L Benzinger, Anne M Fagan, Jason Hassenstab, Andrei G Vlassenko, Jie Luo, Nigel J Cairns, Jon J Christensen, John C Morris, Dmitriy A Yablonskiy
BACKGROUND: Alzheimer disease (AD) affects at least 5 million individuals in the USA alone stimulating an intense search for disease prevention and treatment therapies as well as for diagnostic techniques allowing early identification of AD during a long pre-symptomatic period that can be used for the initiation of prevention trials of disease-modifying therapies in asymptomatic individuals. METHODS: Our approach to developing such techniques is based on the Gradient Echo Plural Contrast Imaging (GEPCI) technique that provides quantitative in vivo measurements of several brain-tissue-specific characteristics of the gradient echo MRI signal (GEPCI metrics) that depend on the integrity of brain tissue cellular structure...
December 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27966748/effect-of-selective-serotonin-reuptake-inhibitors-on-expression-of-5-ht1ar-and-neurotransmitters-in-rats-with-vascular-dementia
#12
K Guo, G Yin, X H Zi, H X Zhu, Q Pan
5-hydroxytryptamine receptor 1A (5-HT1AR) is closely associated with cognitive functions. Selective serotonin reuptake inhibitors (SSRIs) can protect individuals from brain damage following ischemia/hypoxia. To investigate the function of SSRIs in vascular dementia (VD), we established a rat model of VD, and observed the effect of SSRIs on the expression of 5-HT1AR mRNA and neurotransmitters. Male SD rats (6 months) were randomly assigned into sham, model, and SSRI groups (N = 30). VD was achieved by permanent ligation of the bilateral common carotid artery...
December 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27959284/the-proposed-use-of-cervical-spinal-cord-stimulation-for-the-treatment-and-prevention-of-cognitive-decline-in-dementias-and-neurodegenerative-disorders
#13
Nestor D Tomycz
Cervical spinal cord stimulation is a well-established treatment for intractable neuropathic upper extremity pain. More than 20years ago it was demonstrated that cervical spinal cord stimulation could engender an increase in cerebral blood flow. Cerebral blood flow has been shown to be decreased in many patients with dementia and in various neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Furthermore, there is evidence that reduced cerebral blood flow worsens neurodegenerative disease and may also predict which patients progress from mild cognitive impairment to full blown Alzheimer's disease...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27942104/serum-thyroid-stimulating-hormone-level-and-relation-with-size-of-hippocampus-in-patients-with-mild-cognitive-disorders
#14
Mohammad-Hossein Daghighi, Masoud Poureisa, Pegah Ahmadi, Mahmoud Reshadatjoo, Sahar Golestani, Mohammad Naghavi-Behzad, Farid Karkon-Shayan
BACKGROUND: Cognitive disorders and dementia are common problems, and Alzheimer's disease is one of the major leading causes of death worldwide. Thyroid hormone disorders as a common problem effect on hippocampus size which as a prognostic factor in dementia. The aim of the present study was to investigate the relationship between serum thyroid-stimulating hormone (TSH) level and the size of hippocampus in patients with mild cognitive disorders. MATERIALS AND METHODS: In a descriptive-analytical study, 41 patients with symptoms of mild cognitive disorders whom referred to take the brain magnetic resonance image (MRI) in a radiology center under the direction of Tabriz University of Medical Sciences (Tabriz, Iran) were evaluated...
November 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27915236/alcohol-and-alzheimer-s-disease-does-alcohol-dependence-contribute-to-beta-amyloid-deposition-neuroinflammation-and-neurodegeneration-in-alzheimer-s-disease
#15
Ashwin Venkataraman, Nicola Kalk, Gavin Sewell, Craig W Ritchie, Anne Lingford-Hughes
AIMS: To investigate the underlying neurobiology between alcohol use, misuse and dependence and cognitive impairment, particularly Alzheimer's disease (AD). METHODS: Review of the literature using searches of Medline, Pubmed, EMBASE, PsycInfo, and meeting abstracts and presentations. RESULTS: The role of alcohol as a risk factor and contributor for cognitive decline associated with AD has received little attention. This is despite the high prevalence of alcohol use, the potential reversibility of a degree of cognitive impairment and the global burden of AD...
December 3, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27903289/changes-in-cerebral-glucose-metabolism-after-3%C3%A2-weeks-of-noninvasive-electrical-stimulation-of-mild-cognitive-impairment-patients
#16
Kyongsik Yun, In-Uk Song, Yong-An Chung
BACKGROUND: Mild cognitive impairment (MCI) is a syndrome that disrupts an individual's cognitive function but preserves activities of daily living. MCI is thought to be a prodromal stage of dementia, which disrupts patients' daily lives and causes severe cognitive dysfunction. Although extensive clinical trials have attempted to slow or stop the MCI to dementia conversion, the results have been largely unsuccessful. The purpose of this study was to determine whether noninvasive electrical stimulation of MCI changes glucose metabolism...
December 1, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27903238/impress-an-implementation-readiness-checklist-developed-using-a-systematic-review-of-randomised-controlled-trials-assessing-cognitive-stimulation-for-dementia
#17
Amy Streater, Aimee Spector, Elisa Aguirre, Jacki Stansfeld, Martin Orrell
BACKGROUND: Research reporting results of clinical trials, psychosocial or technological interventions frequently omit critical details needed to inform implementation in practice. The aim of this article is to develop an Implementation Readiness (ImpRess) checklist, that includes criteria deemed useful in measuring readiness for implementation and apply it to trials of cognitive stimulation in dementia, providing a systematic review of their readiness for widespread implementation. METHODS: Five electronic databases were searched...
December 1, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27886013/is-salivary-chromogranin-a-a-valid-psychological-stress-biomarker-during-sensory-stimulation-in-people-with%C3%A2-advanced-dementia
#18
Vanessa Valdiglesias, Ana Maseda, Laura Lorenzo-López, Eduardo Pásaro, José C Millán-Calenti, Blanca Laffon
Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation environment (MSSE) in a Snoezelen room produce changes in sCgA in severely demented older patients, and to assess the possible existence of differences in sCgA levels between the two types of interventions. Older adults with severe dementia (n = 22) were randomly assigned to two intervention groups. They participated in MSSE or individualized music interventions in 30-min weekly sessions for 16 weeks...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27874842/efficacy-of-video-music-therapy-on-quality-of-life-improvement-in-a-group-of-patients-with-alzheimer-s-disease-a-pre-post-study
#19
Ivan Rubbi, Daniela Magnani, Giada Naldoni, Rosaria Di Lorenzo, Valeria Cremonini, Patrizia Capucci, Giovanna Artioli, Paola Ferri
BACKGROUND AND AIM OF THE STUDY: Alzheimer's disease is the most common degenerative dementia with a predominantly senile onset. The difficult management of altered behaviour related to this disorder, poorly responsive to pharmacological treatments, has stimulated growth in non-pharmacological interventions, such as music therapy, whose effectiveness has not been supported by the literature up to now. The aim of this study was to evaluate the efficacy of video-music therapy on quality of life improvement in Patients affected by Alzheimer's Disease (AD)...
November 22, 2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27861718/effect-of-cognitively-stimulating-activities-on-symptom-management-of-delirium-superimposed-on-dementia-a-randomized-controlled-trial
#20
Ann Kolanowski, Donna Fick, Mark Litaker, Paula Mulhall, Linda Clare, Nikki Hill, Jacqueline Mogle, Malaz Boustani, David Gill, Andrea Yevchak-Sillner
OBJECTIVE: To determine whether cognitively stimulating activities would reduce duration and severity of delirium and improve cognitive and physical function to a greater extent than usual care. DESIGN: Single-blind randomized clinical trial. SETTING: Eight post-acute care (PAC) facilities. PARTICIPANTS: Community-dwelling older adults with dementia and delirium (N = 283). INTERVENTION: Research staff provided cognitively stimulating activities daily for up to 30 days...
December 2016: Journal of the American Geriatrics Society
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