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hemostatic chitosan

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https://www.readbyqxmd.com/read/28686242/keratin-dissolution-extraction-and-biomedical-application
#1
REVIEW
Amin Shavandi, Tiago H Silva, Adnan A Bekhit, Alaa El-Din A Bekhit
Keratinous materials such as wool, feathers and hooves are tough unique biological co-products that usually have high sulfur and protein contents. A high cystine content (7-13%) differentiates keratins from other structural proteins, such as collagen and elastin. Dissolution and extraction of keratin is a difficult process compared to other natural polymers, such as chitosan, starch, collagen, and a large-scale use of keratin depends on employing a relatively fast, cost-effective and time efficient extraction method...
July 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28625215/assessing-coagulation-by-rotational-thromboelastometry-rotem-in-rivaroxaban-anticoagulated-blood-using-hemostatic-agents
#2
Jonathan Bar, Alexa David, Tarek Khader, Mary Mulcare, Christopher Tedeschi
Introduction The use of direct oral anticoagulants (DOACs) such as rivaroxaban (Xarelto) is increasingly common. However, therapies for reversing anticoagulation in the event of hemorrhage are limited. This study investigates the ability of hemostatic agents to improve the coagulation of rivaroxaban-anticoagulated blood, as measured by rotational thromboelastometry (ROTEM). Hypothesis/Problem If a chitosan-based hemostatic agent (Celox), which works independently of the clotting cascade, is applied to rivaroxaban-anticoagulated blood, it should improve coagulation by decreasing clotting time (CT), decreasing clot formation time (CFT), and increasing maximum clot firmness (MCF)...
June 19, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28532047/porous-chitosan-microspheres-for-application-as-quick-in-vitro-and-in-vivo-hemostat
#3
Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28521997/biodegradable-collagen-sponge-reinforced-with-chitosan-calcium-pyrophosphate-nanoflowers-for-rapid-hemostasis
#4
Tingsheng Yan, Feng Cheng, Xinjing Wei, Yudong Huang, Jinmei He
Efficient and biodegradable hemostatic materials become increasingly important in civilian and military clinical. However, traditional hemostatic materials are difficult to achieve expected effects especially in parenchymal organs with rich vascularity. In facing these challenges, we designed a biodegradable collagen sponge reinforced with chitosan/calcium pyrophosphate nanoflowers (CPNFs-Col sponge) for rapid hemostasis. With specific performances, such as rapid water absorption ability, the positive surface rich in amino groups and high specific surface area (952...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28452963/bioresponsive-materials-for-drug-delivery-based-on-carboxymethyl-chitosan-poly-%C3%AE-glutamic-acid-composite-microparticles
#5
Xiaoting Yan, Zongrui Tong, Yu Chen, Yanghe Mo, Huaiyu Feng, Peng Li, Xiaosai Qu, Shaohua Jin
Carboxymethyl chitosan (CMCS) microparticles are a potential candidate for hemostatic wound dressing. However, its low swelling property limits its hemostatic performance. Poly(γ-glutamic acid) (PGA) is a natural polymer with excellent hydrophilicity. In the current study, a novel CMCS/PGA composite microparticles with a dual-network structure was prepared by the emulsification/internal gelation method. The structure and thermal stability of the composite were determined by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA)...
April 28, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28207269/biocompatible-injectable-hydrogel-with-potent-wound-healing-and-antibacterial-properties
#6
Jiaul Hoque, Relekar G Prakash, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Two component injectable hydrogels that cross-link in situ have been used as noninvasive wound-filling devices, i.e., sealants. These materials carry a variety of functions at the wound sites, such as sealing leaks, ceasing unwanted bleeding, binding tissues together, and assisting in wound healing processes. However, commonly used sealants typically lack antibacterial properties. Since bacterial infection at the wound site is very common, bioadhesive materials with intrinsic antibacterial properties are urgently required...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28131944/a-novel-injectable-tissue-adhesive-based-on-oxidized-dextran-and-chitosan
#7
Biji Balakrishnan, Dawlee Soman, Umashanker Payanam, Alexandre Laurent, Denis Labarre, Athipettah Jayakrishnan
A surgical adhesive that can be used in different surgical situations with or without sutures is a surgeons' dream and yet none has been able to fulfill many such demanding requirements. It was therefore a major challenge to develop an adhesive biomaterial that stops bleeding and bond tissues well, which at the same time is non-toxic, biocompatible and yet biodegradable, economically viable and appealing to the surgeon in terms of the simplicity of application in complex surgical situations. With this aim, we developed an in situ setting adhesive based on biopolymers such as chitosan and dextran...
January 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27998147/chitosan-coated-diatom-silica-as-hemostatic-agent-for-hemorrhage-control
#8
Chao Feng, Jing Li, Guang Sheng Wu, Yu Zhi Mu, Ming Kong, Chang Qing Jiang, Xiao Jie Cheng, Ya Liu, Xi Guang Chen
Uncontrolled hemorrhage leads to high death risk both in military and civilian trauma. Current hemostatic agents still have various limitations and side effects. In this study, natural diatom silica obtained from diatomite and diatom culture was purified and developed for hemorrhage control. To improve the biocompatibility and hemostatic performance of diatom silica, a series of chitosan-coated diatom (CS-diatom) was developed. The composition of CS-diatom prepared was optimized by in vitro hemocompatibility and blood coagulation evaluation for that prepared with 0...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27979487/hydrophobically-modified-chitosan-gauze-a-novel-topical-hemostat
#9
Apurva Chaturvedi, Matthew B Dowling, John P Gustin, Thomas M Scalea, Srinivasa R Raghavan, Jason D Pasley, Mayur Narayan
BACKGROUND: Currently, the standard of care for treating severe hemorrhage in a military setting is Combat Gauze (CG). Previous work has shown that hydrophobically modified chitosan (hm-C) has significant hemostatic capability relative to its native chitosan counterpart. This work aims to evaluate gauze coated in hm-C relative to CG as well as ChitoGauze (ChG) in a lethal in vivo hemorrhage model. METHODS: Twelve Yorkshire swine were randomized to receive either hm-C gauze (n = 4), ChG (n = 4), or CG (n = 4)...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27769944/functional-improvement-of-hemostatic-dressing-by-addition-of-recombinant-batroxobin
#10
Gyeung Mi Seon, Mi Hee Lee, Byeong-Ju Kwon, Min Sung Kim, Min-Ah Koo, Dohyun Kim, Young Seomun, Jong-Tak Kim, Jong-Chul Park
Although a number of natural materials have been used as hemostatic agents, many substances do not act quickly enough. Here, we created a novel dressings using collagen and chitosan with recombinant batroxobin (r-Bat) to promote faster and more effective hemostasis. We hypothesized that r-Bat would promote synergetic blood coagulation because it contains a blood coagulation active site different than those of collagen and chitosan. Our results suggest that each substances can maintain hemostatic properties while in the mixed dressings and that our novel hemostatic dressings promotes potent control of bleeding, as demonstrated by a whole blood assay and rat hemorrhage model...
October 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27760028/the-effectiveness-of-modified-seton-and-modified-combat-gauze-in-controlling-severe-hemorrhaging-during-operations-of-uniformed-services
#11
Z Adamiak, D Bukowiecka, P Jastrzębski, M Jałyński, P Holak, J Głodek, G Gudzbeler
Hemorrhaging from large vessels poses a serious problem in emergency situations when blood loss needs to be immediately controlled. The aim of the study was to compare the effectiveness of two hemostatic dressings in controlling bleeding from a surgically punctured femoral artery. The study was performed on thirteen pigs divided into two groups, of six and seven pigs, respectively. Combat gauze covered with ChitoClear hqg 95 chitosan and Protanal LF10/60 FT sodium alginate was used in the first group, seton covered with identical substances was uses in the second group...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27717239/strong-and-rapidly-self-healing-hydrogels-potential-hemostatic-materials
#12
Weijuan Huang, Yixiang Wang, Yun Chen, Yanteng Zhao, Qiang Zhang, Xiang Zheng, Lingyun Chen, Lina Zhang
Benzaldehyde-terminated telechelic four-armed polyethylene glycol (PEG-BA) is synthesized and cross-linked with carboxymethyl chitosan (CMC) to form dynamic hydrogels with strong mechanical performance. The gelation temperature and time, mechanical performance, and self-healing behaviors are systematically investigated. The hydrogels have good storage modulus up to 3162.06 ± 21.06 Pa, comparable to conventional bulk hydrogels. The separated alternate hydrogel lines connect together to become an integrated hydrogel film after 5 min at room temperature without any external intervention...
November 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27598584/hemostatic-efficacy-of-local-chitosan-linear-polymer-granule-in-an-experimental-sheep-model-with-severe-bleeding-of-arteria-and-vena-femoralis
#13
RANDOMIZED CONTROLLED TRIAL
Gürkan Ersoy, Ülkümen Rodoplu, Osman Yılmaz, Necati Gökmen, Alper Doğan, Özgür Dikme, Aslı Aydınoğlu, Okyanus Orhon
BACKGROUND: The aim of the present study was to evaluate the hemostatic effect of chitosan linear polymer in a sheep model with femoral bleeding. METHODS: Following induction of anesthesia and intubation of sheep, groin injury was induced to initiate hemorrhage. Animals were randomly assigned to study and control groups. In the control group, absorbent pads were packed on the wound, and pressure was supplied by a weight placed over the dressing. In the study group, chitosan linear polymer was poured onto the bleeding site; absorbent pads and pressure were applied in the same manner...
May 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27423307/determination-of-efficacy-of-a-novel-alginate-dressing-in-a-lethal-arterial-injury-model-in-swine
#14
Matthew B Dowling, Apurva Chaturvedi, Ian C MacIntire, Vishal Javvaji, John Gustin, Srinivasa R Raghavan, Thomas M Scalea, Mayur Narayan
INTRODUCTION: Alginate is a biocompatible polysaccharide that is commonly used in the pharmaceutical, biomedical, cosmetic, and food industries. Though solid dressings composed of alginate can absorb water and promote wound healing, they are not effective hemostatic materials, particularly against massive hemorrhage. The purpose of this study is to attempt to increase the hemostatic capabilities of alginate by means of hydrophobic modification. Previous studies have illustrated that modifying a different polysaccharide, chitosan, in this way enhances its hemostatic efficacy as well as its adhesion to tissue...
October 2016: Injury
https://www.readbyqxmd.com/read/27126123/active-nano-microbilayer-hemostatic-agents-for-diabetic-rat-bleeding-model
#15
Zeynep Karahaliloğlu, Murat Demirbilek, İbrahim Ulusoy, Berrak Gümüşkaya, Emir Baki Denkbaş
Patients with diabetes mellitus have an increased cardiovascular risk due to the abnormality of hemostatic system components. Therefore, hemostasis is an important concept when considering that diabetics are under risk due to potential bleeding complications during surgical operation. The aim of our study was to examine the efficiency of a fabricated nano/microbilayer hemostatic dressing for bleeding control in diabetic patients. For this purpose, we prepared a nano/microbilayer hemostatic dressing that has a porous sublayer, including chitosan (CTS), bacterial cellulose (BC) as basement and active agents in coagulation cascade, such as vitamin K (Vit K), protamine sulfate (PS), and kaolin (Kao) as a filler and an upper layer consisting of silk fibroin (SF) or SF/phosphatidylcholine (PC) blend to achieve complete hemostasis in diabetic rats...
April 29, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27112893/preparation-and-characterization-of-chitosan-gelatin-pva-hydrogel-for-wound-dressings
#16
Lihong Fan, Huan Yang, Jing Yang, Min Peng, Jin Hu
Chitosan (CS)/gelatin (Gel)/polyvinyl alcohol (PVA) hydrogels were prepared by the gamma irradiation method for usage in wound dressing applications. Chitosan and gelatin solution was mixed with poly(vinyl alcohol) (PVA) solution at different weight ratios of CS/Gel of 1:3, 1:2, 1:1, 2:1 and 3:1. The hydrogels irradiated at 40kGy. The structure of the hydrogels was characterized by using FT-IR and SEM. The CS/Gel/PVA hydrogels were characterized for physical properties and blood clotting activity. The tensile strength of CS/Gel/PVA hydrogel enhanced than on the basis of the Gel/PVA hydrogel...
August 1, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27040191/preparation-of-porous-carboxymethyl-chitosan-grafted-poly-acrylic-acid-superabsorbent-by-solvent-precipitation-and-its-application-as-a-hemostatic-wound-dressing
#17
Yu Chen, Yong Zhang, Fengju Wang, Weiwei Meng, Xinlin Yang, Peng Li, Jianxin Jiang, Huimin Tan, Yongfa Zheng
The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic wound dressing was investigated...
June 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26833305/effect-of-plasma-sterilization-on-the-hemostatic-efficacy-of-a-chitosan-hemostatic-agent-in-a-rat-model
#18
Andrew Crofton, John Chrisler, Samuel Hudson, Serkan Inceoglu, Floyd Petersen, Wolff Kirsch
INTRODUCTION: The United States military has had success with chitosan (CS)-based hemostatic agents to control trauma-induced hemorrhages. Despite the positive reviews, additional physical forms of CS may enhance its hemostatic efficacy. Additionally, standard sterilization techniques may negatively affect the hemostatic efficacy of CS. We studied the effects of a CS-based hemostatic pad, the Clo-Sur P.A.D.™ (Scion Cardio-Vascular, Inc.), on severe femoral vessel bleeding in a rat model...
February 2016: Advances in Therapy
https://www.readbyqxmd.com/read/26634950/preparation-of-carboxymethyl-chitosan-microspheres-and-their-application-in-hemostasis
#19
Lu Liu, Qi Lv, Qingyun Zhang, Hui Zhu, Wei Liu, Guiru Deng, Yuqiang Wu, Chaofeng Shi, Hui Li, Lingzhi Li
OBJECTIVE: Chitosan (CS) is currently used as a hemostatic agent in emergencies and in military settings. However, its application is limited owing to its poor hydrophilia at neutral pH. Carboxymethyl chitosan (CMCS) is an important, water-soluble derivative of CS. In this study, we prepared CS and CMCS microspheres (CSMs and CMCSMs, respectively) and evaluated their hemostatic effect. METHODS: To prepare the microspheres of various sizes, we used the emulsion cross-linking technique...
December 4, 2015: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/26620128/comparison-of-hemostatic-dressings-for-superficial-wounds-using-a-new-spectrophotometric-coagulation-assay
#20
COMPARATIVE STUDY
Julian-Dario Rembe, Julia K Böhm, Carolin Fromm-Dornieden, Nadine Schäfer, Marc Maegele, Matthias Fröhlich, Ewa K Stuermer
BACKGROUND: Due to demographical changes the number of elderly patients depending on oral anticoagulation is expected to rise. Prolonged bleeding times in case of traumatic injuries represent the drawback of these medications, not only in major trauma, but also in superficial wounds. Therefore, dressings capable of accelerating coagulation onset and shortening bleeding times are desirable for these patients. METHODS: The hemostatic potential and physical properties of different types of superficial wound dressings (standard wound pad, two alginates, chitosan, collagen (Lyostypt(®)), oxidized cellulose, and QuikClot(®)) were assessed in vitro...
November 30, 2015: Journal of Translational Medicine
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