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https://www.readbyqxmd.com/read/28444478/the-association-between-geometry-and-wall-stress-in-emergently-repaired-abdominal-aortic-aneurysms
#1
Sathyajeeth S Chauhan, Carlos A Gutierrez, Mirunalini Thirugnanasambandam, Victor De Oliveira, Satish C Muluk, Mark K Eskandari, Ender A Finol
Abdominal aortic aneurysm (AAA) is a prevalent cardiovascular disease characterized by the focal dilation of the aorta, which supplies blood to all the organs and tissues in the systemic circulation. With the AAA increasing in diameter over time, the risk of aneurysm rupture is generally associated with the size of the aneurysm. If diagnosed on time, intervention is recommended to prevent AAA rupture. The criterion to decide on surgical intervention is determined by measuring the maximum diameter of the aneurysm relative to the critical value of 5...
April 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28444139/multi-label-classifier-based-on-histogram-of-gradients-for-predicting-the-anatomical-therapeutic-chemical-class-classes-of-a-given-compound
#2
Loris Nanni, Sheryl Brahnam
Motivation: Given an unknown compound, is it possible to predict its ATC (Anatomical Therapeutic Chemical) class/classes? This is a challenging yet important problem since such a prediction could be used to deduce not only a compound's possible active ingredients but also its therapeutic, pharmacological, and chemical properties, thereby substantially expediting the pace of drug development. The problem is challenging because some drugs and compounds belong to two or more ATC classes, making machine learning extremely difficult...
April 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28443285/high-grade-gliomas-exhibit-higher-peritumoral-fractional-anisotropy-and-lower-mean-diffusivity-than-intracranial-metastases
#3
Kevin S Holly, Benjamin J Barker, Derrick Murcia, Rebekah Bennett, Piyush Kalakoti, Christina Ledbetter, Eduardo Gonzalez-Toledo, Anil Nanda, Hai Sun
Differentiating high-grade gliomas and intracranial metastases through non-invasive imaging has been challenging. Here, we retrospectively compared both intratumoral and peritumoral fractional anisotropy (FA), mean diffusivity (MD), and fluid-attenuated inversion recovery (FLAIR) measurements between high-grade gliomas and metastases. Two methods were utilized to select peritumoral region of interest (ROI). The first method utilized the manual placement of four ROIs adjacent to the lesion. The second method utilized a semiautomated and proprietary MATLAB script to generate an ROI encompassing the entire tumor...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28441410/creating-and-parameterizing-patient-specific-deep-brain-stimulation-pathway-activation-models-using-the-hyperdirect-pathway-as-an-example
#4
Kabilar Gunalan, Ashutosh Chaturvedi, Bryan Howell, Yuval Duchin, Scott F Lempka, Remi Patriat, Guillermo Sapiro, Noam Harel, Cameron C McIntyre
BACKGROUND: Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both academic and industrial research, as well as clinical software systems. However, the exact methodology for creating patient-specific DBS models can vary substantially and important technical details are often missing from published reports. OBJECTIVE: Provide a detailed description of the assembly workflow and parameterization of a patient-specific DBS pathway-activation model (PAM) and predict the response of the hyperdirect pathway to clinical stimulation...
2017: PloS One
https://www.readbyqxmd.com/read/28441329/implementation-of-an-electronic-ionosonde-to-monitor-the-earth-s-ionosphere-via-a-projected-column-through-usrp
#5
Jhon Jairo Barona Mendoza, Carlos Fernando Quiroga Ruiz, Carlos Rafael Pinedo Jaramillo
This document illustrates the processes carried out for the construction of an ionospheric sensor or ionosonde, from a universal software radio peripheral (USRP), and its programming using GNU-Radio and MATLAB. The development involved the in-depth study of the characteristics of the ionosphere, to apply the corresponding mathematical models used in the radar-like pulse compression technique and matched filters, among others. The sensor operates by firing electromagnetic waves in a frequency sweep, which are reflected against the ionosphere and are received on its return by the receiver of the instrument, which calculates the reflection height through the signal offset...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28437961/novel-asymmetric-cryptosystem-based-on-distorted-wavefront-beam-illumination-and-double-random-phase-encoding
#6
Honghao Yu, Jun Chang, Xin Liu, Chuhan Wu, Yifan He, Yongjian Zhang
Herein, we propose a new security enhancing method that employs wavefront aberrations as optical keys to improve the resistance capabilities of conventional double-random phase encoding (DRPE) optical cryptosystems. This study has two main innovations. First, we exploit a special beam-expander afocal-reflecting to produce different types of aberrations, and the wavefront distortion can be altered by changing the shape of the afocal-reflecting system using a deformable mirror. Then, we reconstruct the wavefront aberrations via the surface fitting of Zernike polynomials and use the reconstructed aberrations as novel asymmetric vector keys...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28435854/a-clinical-trial-simulation-evaluating-epinephrine-pharmacokinetics-at-various-dosing-frequencies-during-cardiopulmonary-resuscitation
#7
Andy R Eugene
OBJECTIVE: This article seeks to test the hypothesis that repeated 1mg intravenous epinephrine dosing intervals of 3-minutes and 5-minutes results in differences in the total drug exposure and the maximum epinephrine concentration using simulated cardiopulmonary resuscitation (CPR) dosing. METHODS: Published population pharmacokinetic parameters were identified in the literature and pharmacokinetic dosing simulations were conducted according to the 2015 American Heart Association guidelines for CPR in adults...
June 2016: MEDtube Science
https://www.readbyqxmd.com/read/28432111/regional-vascular-density-visual-field-sensitivity-relationship-in-glaucoma-according-to-disease-severity
#8
Joong Won Shin, Jiyun Lee, Junki Kwon, Jaewan Choi, Michael S Kook
AIMS: To study whether there are global and regional relationships between peripapillary vascular density (pVD) assessed by optical coherence tomography angiography (OCT-A) and visual field (VF) mean sensitivity at different glaucoma stages. METHODS: Microvascular images and peripapillary retinal nerve fibre layer (pRNFL) thicknesses were obtained using a Cirrus OCT-A device in 91 glaucoma subjects. The pVD was measured at various spatial locations according to the Garway-Heath map, using a MATLAB software (The MathWorks, Natick, Massachusetts)...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28431087/a-method-for-learning-a-sparse-classifier-in-the-presence-of-missing-data-for-high-dimensional-biological-datasets
#9
Kristen Severson, Brinda Monian, J Christopher Love, Richard D Braatz
Motivation: This work addresses two common issues in building classification models for biological or medical studies: learning a sparse model, where only a subset of a large number of possible predictors is used, and training in the presence of missing data. This work focuses on supervised generative binary classification models, specifically linear discriminant analysis (LDA). The parameters are determined using an expectation maximization algorithm to both address missing data and introduce priors to promote sparsity...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#10
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28430225/phase-shifting-by-wavelength-modulation-in-a-cube-beam-splitter-interferometer
#11
Uriel Rivera-Ortega
A low-cost and fully automated process for phase-shifting interferometry by continuously changing the input voltage of a laser diode under the scheme of a cube beam splitter interferometer, performing as a two-window common-path interferometric setup, is presented. The input signal of a laser diode is controlled by a data acquisition device which permits a change in its wavelength according to its tunability features. The automation and data analysis is done using LabVIEW in combination with MATLAB. By using the Carré algorithm, the phase map is obtained...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429329/hydrogen-production-and-microbial-kinetics-of-clostridium-termitidis-in-mono-culture-and-co-culture-with-clostridium-beijerinckii-on-cellulose
#12
Maritza Gomez-Flores, George Nakhla, Hisham Hafez
Cellulose utilization by hydrogen producers remains an issue due to the low hydrogen yields reported and the pretreatment of cellulose prior to fermentation requires complex and expensive steps. Clostridium termitidis is able to breakdown cellulose into glucose and produce hydrogen. On the other hand, Clostridium beijerinckii is not able to degrade cellulose but is adept at hydrogen production from glucose; therefore, it was chosen to potentially enhance hydrogen production when co-cultured with C. termitidis on cellulose...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28423830/bridging-the-semantic-gap-between-diagnostic-histopathology-and-image-analysis
#13
Lamine Traore, Yannick Kergosien, Daniel Racoceanu
With the wider acceptance of Whole Slide Images (WSI) in histopathology domain, automatic image analysis algorithms represent a very promising solution to support pathologist's laborious tasks during the diagnosis process, to create a quantification-based second opinion and to enhance inter-observer agreement. In this context, reference vocabularies and formalization of the associated knowledge are especially needed to annotate histopathology images with labels complying with semantic standards. In this work, we elaborate a sustainable triptych able to bridge the gap between pathologists and image analysis scientists...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423766/dermatology-disease-prediction-based-on-two-step-cascade-genetic-algorithm-optimization-of-anfis-parameters
#14
Aja Avdagic, Lejla Begic Fazlic
The aim of this study is to present novel algorithms for prediction of dermatological disease using only dermatological clinical features and diagnoses collected in real conditions. A combination of the Adaptive Neuro-Fuzzy Inference Systems (ANFIS) and Genetic algorithm (GA) for ANFIS subtractive clustering parameter optimization has been suggested for the first level of fuzzy model optimization. After that, a genetic optimized ANFIS fuzzy structure is used as input in GA for the second level of fuzzy model optimization...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28422681/fast-median-filtering-for-phase-or-orientation-data
#15
Martin Storath, Andreas Weinmann
Median filtering is among the most utilized tools for smoothing real-valued data, as it is robust, edge-preserving, valuepreserving, and yet can be computed efficiently. For data living on the unit circle, such as phase data or orientation data, a filter with similar properties is desirable. For these data, there is no unique means to define a median; so we discuss various possibilities. The arc distance median turns out to be the only variant which leads to robust, edge-preserving and value-preserving smoothing...
April 12, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28422421/results-of-a-10-year-survey-of-workload-for-10-treatment-vaults-at-a-high-throughput-comprehensive-cancer-center
#16
Ziad H Saleh, Jeho Jeong, Brian Quinn, James Mechalakos, Jean St Germain, Lawrence T Dauer
The workload for shielding purposes of modern linear accelerators (linacs) consists of primary and scatter radiation which depends on the dose delivered to isocenter (cGy) and leakage radiation which depends on the monitor units (MUs). In this study, we report on the workload for 10 treatment vaults in terms of dose to isocenter (cGy), monitor units delivered (MUs), number of treatment sessions (Txs), as well as, use factors (U) and modulation factors (CI) for different treatment techniques. The survey was performed for the years between 2006 and 2015 and included 16 treatment machines which represent different generations of Varian linear accelerators (6EX, 600C, 2100C, 2100EX, and TrueBeam) operating at different electron and x-ray energies (6, 9, 12, 16 and 20 MeV electrons and, 6 and 15 MV x-rays)...
April 19, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28419171/ultrasound-texture-analysis-association-with-lymph-node-metastasis-of-papillary-thyroid-microcarcinoma
#17
Soo-Yeon Kim, Eunjung Lee, Se Jin Nam, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Kyung Hwa Han, Jin Young Kwak
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28419095/effectiveness-of-a-live-oral-human-rotavirus-vaccine-after-programmatic-introduction-in-bangladesh-a-cluster-randomized-trial
#18
K Zaman, David A Sack, Kathleen M Neuzil, Mohammad Yunus, Lawrence H Moulton, Jonathan D Sugimoto, Jessica A Fleming, Ilias Hossain, Shams El Arifeen, Tasnim Azim, Mustafizur Rahman, Kristen D C Lewis, Andrea J Feller, Firdausi Qadri, M Elizabeth Halloran, Alejandro Cravioto, John C Victor
BACKGROUND: Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on Immunization reviewed available data and concluded that there was no evidence for the efficacy or effectiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10 wk of age. Additionally, the effectiveness of programmatic rotavirus vaccination, including possible indirect effects, has not been assessed in low-resource populations in Asia...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28417171/resolution-optimized-headspace-gas-chromatography-ion-mobility-spectrometry-hs-gc-ims-for-non-targeted-olive-oil-profiling
#19
Natalie Gerhardt, Markus Birkenmeier, Daniel Sanders, Sascha Rohn, Philipp Weller
A prototype gas chromatography-ion mobility spectrometry (GC-IMS) system, hyphenating temperature-ramped headspace GC to a modified drift time IMS cell, was evaluated and compared to a conventional, isothermal capillary column (CC)-IMS system on the example of the geographical differentiation of extra virgin olive oils (EVOO) from Spain and Italy. It allows orthogonal, 2D separation of complex samples and individual detection of compounds in robust and compact benchtop systems. The information from the high-resolution 3D fingerprints of volatile organic compound (VOC) fractions of EVOO samples were extracted by specifically developed chemometric MATLAB® routines to differentiate between the different olive oil provenances...
April 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28417100/data-for-trots-the-radiotherapy-optimisation-test-set
#20
Sebastiaan Breedveld, Ben Heijmen
The Radiotherapy Optimisation Test Set (TROTS) is an extensive set of problems originating from radiotherapy (radiation therapy) treatment planning. This dataset is created for 2 purposes: (1) to supply a large-scale dense dataset to measure performance and quality of mathematical solvers, and (2) to supply a dataset to investigate the multi-criteria optimisation and decision-making nature of the radiotherapy problem. The dataset contains 120 problems (patients), divided over 6 different treatment protocols/tumour types...
June 2017: Data in Brief
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