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Complexity Sciences

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https://www.readbyqxmd.com/read/29218555/sas-based-structural-modelling-and-model-validation
#1
Maxim V Petoukhov, Anne Tuukkanen
Small angle scattering of X-rays (SAXS) and neutrons (SANS) is a structural technique to study disordered systems with chaotic orientations of scattering inhomogeneities at low resolution. An important example of such systems are solutions of biological macromolecules. Rapid development in the methodology for solution scattering data interpretation and model building during the last two decades brought the analysis far beyond the determination of just few overall structural parameters (which was the only possibility in the past) and ensured SAS a firm position in the methods palette of the modern life sciences...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218341/templated-co-assembly-into-nanorods-of-polyanions-and-artificial-virus-capsid-proteins
#2
A Hernandez-Garcia, M A Cohen Stuart, R de Vries
Recombinant triblock polypeptides C-Sn-B, where C is a 400 amino acid long hydrophilic random coil block, Sn is a multimer of the silk-like octapeptide S = (GAGAGAGQ), and B = K12 is an oligolysine, have previously been shown to encapsulate double stranded DNA into rod-shaped, virus-like particles. In order to gain insight of the co-assembly process, and in order to be able to use these proteins for templating other types of nanorods, we here explore their co-assembly with a range of polyanionic templates: poly(acrylic acids) (PAA) of a wide range of lengths, poly(styrene sulphonate) (PSS) and the stiff anionic polysaccharide xanthan...
December 8, 2017: Soft Matter
https://www.readbyqxmd.com/read/29218304/from-invention-to-innovation-risk-analysis-to-integrate-one-health-technology-in-the-dairy-farm
#3
Andrea Lombardo, Carlo Boselli, Simonetta Amatiste, Simone Ninci, Chiara Frazzoli, Roberto Dragone, Alberto De Rossi, Gerardo Grasso, Alberto Mantovani, Giovanni Brajon
Current Hazard Analysis Critical Control Points (HACCP) approaches mainly fit for food industry, while their application in primary food production is still rudimentary. The European food safety framework calls for science-based support to the primary producers' mandate for legal, scientific, and ethical responsibility in food supply. The multidisciplinary and interdisciplinary project ALERT pivots on the development of the technological invention (BEST platform) and application of its measurable (bio)markers-as well as scientific advances in risk analysis-at strategic points of the milk chain for time and cost-effective early identification of unwanted and/or unexpected events of both microbiological and toxicological nature...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29218283/early-reconstructions-of-complex-lower-extremity-battlefield-soft-tissue-wounds
#4
Ali Ebrahimi, Nasrin Nejadsarvari, Azin Ebrahimi, Hamid Reza Rasouli
BACKGROUND: Severe lower extremity trauma as a devastating combat related injury is on the rise and this presents reconstructive surgeons with significant challenges to reach optimal cosmetic and functional outcomes. This study assessed early reconstructions of complex lower extremity battlefield soft tissue wounds. METHODS: This was a prospective case series study of battled field injured patients which was done in the Department of Plastic Surgery, Baqiyatallah University of Medical Sciences hospitals, Tehran, Iran between 2013-2015...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29217902/magnitude-severity-and-outcome-of-traumatic-pancreatic-injury-at-a-level-i-trauma-center-in-india
#5
Amit Gupta, Subodh Kumar, Sanjay Kumar Yadav, Biplab Mishra, Maneesh Singhal, Atin Kumar, Pramod Garg
Pancreatic injury is an uncommon and frequently missed injury in abdominal trauma patients. However, missed pancreatic injury is associated with significant morbidity and mortality. This study was conducted to know the burden of pancreatic injury and its outcome in our setup. A retrospective analysis of 53 patients with pancreatic injury from January 2008 through March 2012 at the Jai Prakash Narayan Apex Trauma Center (JPNATC), All India Institute of Medical Sciences (AIIMS), New Delhi. Pancreatic injuries were present in 1...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29214696/microemulsions-micelles-and-functional-gels-how-colloid-and-soft-matter-preserve-works-of-art
#6
David Chelazzi, Rodorico Giorgi, Piero Baglioni
Colloid Science provides fundamental knowledge to fields such as pharmaceutical, detergency, paint and food industry. An exciting application is art conservation, which poses a challenge owing to the complex range of interfacial interactions involved in restoring artefacts. Currently, the majority of the most performing and environmentally safe cleaning and consolidation agents for artworks belong to soft matter and colloids. We report here on the development and application of increasingly complex systems, from microemulsions to semi-interpenetrating hydrogels containing such fluids...
December 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29214222/reasons-to-pursue-a-career-in-medicine-a-qualitative-study-in-sierra-leone
#7
Aniek Woodward, Suzanne Thomas, Mohamed Bella Jalloh, John Rees, Andrew Leather
Background: Many low-income and crises-affected countries like Sierra Leone struggle with the recruitment and retention of their health professionals, particularly nurses and doctors. There are multiple factors that influence the 'recruitment to retention' pipeline. The first stage of an exploration into the issues influencing the availability of qualified health care workers may focus on the aspects which influence their entry into relevant educational programmes. This paper explores the reasons given by junior doctors in Sierra Leone for wanting to become a doctor...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29212475/implementation-of-shared-decision-making-in-oncology-development-and-pilot-study-of-a-nurse-led-decision-coaching-programme-for-women-with-ductal-carcinoma-in-situ
#8
Birte Berger-Höger, Katrin Liethmann, Ingrid Mühlhauser, Anke Steckelberg
BACKGROUND: To implement informed shared decision-making (ISDM) in breast care centres, we developed and piloted an inter-professional complex intervention. METHODS: We developed an intervention consisting of three components: an evidence-based patient decision aid (DA) for women with ductal carcinoma in situ, a decision-coaching led by specialised nurses (breast care nurses and oncology nurses) and structured physician encounters. In order to enable professionals to gain ISDM competencies, we developed and tested a curriculum-based training programme for specialised nurses and a workshop for physicians...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29210342/antibiotics-potentiating-potential-of-catharanthine-against-superbug-pseudomonas-aeruginosa
#9
Gaurav Raj Dwivedi, Rekha Tyagi, Sanchita Gupta, Shubhandra Tripathi, Sanghamitra Pati, Santosh K Srivastava, Mahendra P Darokar, Ashok Sharma
Multidrug resistance (MDR) put an alarming situation like preantibiotic era which compels us to invigorate the basic science of anti-infective chemotherapy. Hence the drug resistant genes/proteins were explored as promising drug targets. Keeping this thing in mind, proteome of Pseudomonas aeruginosa PA01 was explored, which resulted in the identification of tripartite protein complexes (MexA, MexB and OprM) as promising drug target for the screening of natural and synthetic inhibitors. The purpose of present investigation was to explore the drug resistance reversal potential mechanism of catharanthine isolated from the leaves of Catharanthus roseous...
December 6, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29210014/scoping-review-of-response-shift-methods-current-reporting-practices-and-recommendations
#10
REVIEW
Tolulope T Sajobi, Ronak Brahmbatt, Lisa M Lix, Bruno D Zumbo, Richard Sawatzky
BACKGROUND: Response shift (RS) has been defined as a change in the meaning of an individual's self-evaluation of his/her health status and quality of life. Several statistical model- and design-based methods have been developed to test for RS in longitudinal data. We reviewed the uptake of these methods in patient-reported outcomes (PRO) literature. METHODS: CINHAHL, EMBASE, Medline, ProQuest, PsycINFO, and Web of Science were searched to identify English-language articles about RS published until 2016...
December 5, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29209272/a-european-perspective-on-auditory-processing-disorder-current-knowledge-and-future-research-focus
#11
Vasiliki Vivian Iliadou, Martin Ptok, Helen Grech, Ellen Raben Pedersen, André Brechmann, Naïma Deggouj, Christiane Kiese-Himmel, Mariola Śliwińska-Kowalska, Andreas Nickisch, Laurent Demanez, Evelyne Veuillet, Hung Thai-Van, Tony Sirimanna, Marina Callimachou, Rosamaria Santarelli, Sandra Kuske, Jose Barajas, Mladen Hedjever, Ozlem Konukseven, Dorothy Veraguth, Tone Stokkereit Mattsson, Jorge Humberto Martins, Doris-Eva Bamiou
Current notions of "hearing impairment," as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as "Auditory Processing Disorder" (APD) or "Central Auditory Processing Disorder" is classified in the current tenth version of the International Classification of diseases as H93...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29208216/clinical-veterinary-proteomics-techniques-and-approaches-to-decipher-the-animal-plasma-proteome
#12
REVIEW
P Ghodasara, P Sadowski, N Satake, S Kopp, P C Mills
Over the last two decades, technological advancements in the field of proteomics have advanced our understanding of the complex biological systems of living organisms. Techniques based on mass spectrometry (MS) have emerged as powerful tools to contextualise existing genomic information and to create quantitative protein profiles from plasma, tissues or cell lines of various species. Proteomic approaches have been used increasingly in veterinary science to investigate biological processes responsible for growth, reproduction and pathological events...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29208000/dynamics-behind-the-scale-up-of-evidence-based-obesity-prevention-protocol-for-a-multi-site-case-study-of-an-electronic-implementation-monitoring-system-in-health-promotion-practice
#13
Kathleen P Conte, Sisse Groen, Victoria Loblay, Amanda Green, Andrew Milat, Lina Persson, Christine Innes-Hughes, Jo Mitchell, Sarah Thackway, Mandy Williams, Penelope Hawe
BACKGROUND: The effectiveness of many interventions to promote health and prevent disease has been well established. The imperative has therefore shifted from amassing evidence about efficacy to scale-up to maximise population-level health gains. Electronic implementation monitoring, or 'e-monitoring', systems have been designed to assist and track the delivery of preventive policies and programs. However, there is little evidence on whether e-monitoring systems improve the dissemination, adoption, and ongoing delivery of evidence-based preventive programs...
December 6, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29207278/collision-induced-unfolding-of-isolated-proteins-in-the-gas-phase-past-present-and-future
#14
REVIEW
Sugyan M Dixit, Daniel A Polasky, Brandon T Ruotolo
Rapidly characterizing the three-dimensional structures of proteins and the multimeric machines they form remains one of the great challenges facing modern biological and medical sciences. Ion mobility-mass spectrometry based techniques are playing an expanding role in characterizing these functional complexes, especially in drug discovery and development workflows. Despite this expansion, ion mobility-mass spectrometry faces many challenges, especially in the context of detecting small differences in protein tertiary structure that bear functional consequences...
December 2, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29205565/binding-profiles-of-self-assembled-supramolecular-cages-from-esi-ms-based-methodology
#15
Carlo Bravin, Elena Badetti, Rakesh Puttreddy, Fangfang Pan, Kari Rissanen, Giulia Licini, Cristiano Zonta
Confined molecular environments own peculiar characteristics that make their properties unique in the field of biological and chemical sciences. In recent years, the advancement of synthetic supramolecular capsules and cages have offered the possibility to interpret the principles behind their self-assembly and functions, leading to new molecular systems which display outstanding properties in molecular recognition and catalysis. Herein, we report a rapid method based on ESI-MS for the determination of binding profiles for linear saturated dicarboxylic acids within a series of different cages...
December 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29205261/report-and-research-agenda-of-the-american-geriatrics-society-and-national-institute-on-aging-bedside-to-bench-conference-on-urinary-incontinence-in-older-adults-a-translational-research-agenda-for-a-complex-geriatric-syndrome
#16
Camille P Vaughan, Alayne D Markland, Phillip P Smith, Kathryn L Burgio, George A Kuchel
The American Geriatrics Society, with support from the National Institute on Aging and other funders, held its ninth Bedside-to-Bench research conference, entitled "Urinary Incontinence in the Older Adult: A Translational Research Agenda for a Complex Geriatric Syndrome," October 16 to 18, 2016, in Bethesda, Maryland. As part of a conference series addressing three common geriatric syndromes-delirium, sleep and circadian rhythm disturbance, and urinary incontinence-the series highlighted relationships and pertinent clinical and pathophysiological commonalities between these conditions...
December 4, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29204968/advantages-to-using-social-behavioral-models-of-medication-adherence-in-research-and-practice
#17
K Rivet Amico, M Mugavero, Marie A Krousel-Wood, Hayden B Bosworth, Jessica S Merlin
Achieving and sustaining high levels of adherence to medication regimens is essential to improving health outcomes, but continues to be a challenge for a sizable proportion of patients. Decades of research suggests that medication adherence is determined by a complex constellation of factors. Social-behavioral science research has focused on creating frameworks that identify which contextual, personal, social, or drug-related factors appear to most influence adherence. Comprehensive models of adherence propose specific structural relationships between these factors that can be used to plan for, implement, and monitor programs that seek to optimize adherence...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29204890/dna-cryptography-and-deep-learning-using-genetic-algorithm-with-nw-algorithm-for-key-generation
#18
Shruti Kalsi, Harleen Kaur, Victor Chang
Cryptography is not only a science of applying complex mathematics and logic to design strong methods to hide data called as encryption, but also to retrieve the original data back, called decryption. The purpose of cryptography is to transmit a message between a sender and receiver such that an eavesdropper is unable to comprehend it. To accomplish this, not only we need a strong algorithm, but a strong key and a strong concept for encryption and decryption process. We have introduced a concept of DNA Deep Learning Cryptography which is defined as a technique of concealing data in terms of DNA sequence and deep learning...
December 5, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29203754/-scientific-research-results-commercialization-as-an-opportunity-for-the-physiotherapy-development
#19
Piotr Pietras, Marek Łyp, Katarzyna Nowicka, Marcin Soliwoda, Mateusz Kruszyński, Daniel Malczewski
Physiotherapy is under the very intensive development. The research carried out around the world result in implementing new forms of therapy. For several years higher education institutions are trying to support scientists in an attempt to commercialize the results of research, although the process is complex. The practice in the world shows that the cooperation of science and business is possible and results in the implementation of modern solutions as real applications. It is important to scientists and people planning a career in science knew the rules and limitations of the above process...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29203135/exploring-three-different-expression-systems-for-recombinant-expression-of-globins-escherichia-coli-pichia-pastoris-and-spodoptera-frugiperda
#20
An Bracke, David Hoogewijs, Sylvia Dewilde
Globins are among the best investigated proteins in biological and medical sciences and represent a prime tool for the study of the evolution of genes and the structure-function relationship of proteins. Here, we explore the recombinant expression of globins in three different expression systems: Escherichia coli, Pichia pastoris and the baculovirus infected Spodoptera frugiperda. We expressed two different human globin types in these three expression systems: I) the well-characterized neuroglobin and II) the uncharacterized, circular permutated globin domain of the large chimeric globin androglobin...
December 1, 2017: Analytical Biochemistry
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