keyword
https://read.qxmd.com/read/38156735/high-vs-regular-dose-recombinant-human-thrombopoietin-plus-cyclosporine-a-in-patients-with-newly-diagnosed-non-severe-aplastic-anemia-a-retrospective-cohort-study
#21
JOURNAL ARTICLE
Yuan Yang, Qinglin Hu, Chen Yang, Miao Chen, Bing Han
BACKGROUND: Cyclosporine A (CsA) and regular doses of recombinant human thrombopoietin (rhTPO) can accelerate platelet recovery in patients with non-severe aplastic anemia (NSAA). However, it is unclear whether CsA plus rhTPO at a higher dose can further increase the efficacy. METHODS: Data from patients with newly diagnosed NSAA, who had been treated with CsA in combination with different doses of rhTPO between February 2021 and August 2021 at Peking Union Medical College Hospital, were reviewed...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38146481/combination-therapy-with-platelet-rich-plasma-and-epidermal-neural-crest-stem-cells-increases-treatment-efficacy-in-vascular-dementia
#22
JOURNAL ARTICLE
Somayeh Akbari, Masoud Haghani, Mojtaba Ghobadi, Etrat Hooshmandi, Afshin Borhani Haghighi, Mohammad Saied Salehi, Sareh Pandamooz, Negar Azarpira, Afsoon Afshari, Shahrbanoo Zabihi, Marzieh Nemati, Mahnaz Bayat
This study aimed to evaluate the efficacy and treatment mechanism of platelet-rich plasma (PRP) and neural crest-derived epidermal stem cells (ESCs) in their administration alone and combination in vascular dementia (VaD) model by two-vessel occlusion (2VO). Methods . Sixty-six rats were divided into six groups: the control, sham, 2VO + vehicle, 2VO + PRP, 2VO + ESC, and 2VO + ESC + PRP. The treated groups received 1 million cells on days 4, 14, and 21 with or without 500  µ l PRP (twice a week) after 2VO...
2023: Stem Cells International
https://read.qxmd.com/read/38134302/traumatic-mid-substance-isolated-vastus-medialis-rupture-in-a-young-athlete-a-case-report
#23
JOURNAL ARTICLE
Steven Elicegui, Mark Stovak, Jordan Dobrich, John Hodges, Vijay Sekhon, Christopher Dolan
CASE: This is the first documented case of an isolated traumatic vastus medialis rupture that occurred in a 14-year-old athlete after direct impact during play. Imaging confirmed a rare mid-substance rupture. The patient underwent conservative management with physical therapy augmented by blood flow restriction therapy (BFRT) and platelet-poor plasma (PPP) injection to regain full function. CONCLUSION: Isolated quadriceps mid-substance tears are rare. Determining an appropriate treatment technique for mid-substance tears is complex...
October 1, 2023: JBJS Case Connector
https://read.qxmd.com/read/38112362/immunity-changes-in-patients-with-acute-maxillofacial-odontogenic-infections-during-treatment-stages-an-analysis
#24
JOURNAL ARTICLE
Oksana V Klitynska, Roksolana Yu Kruchak, Viacheslav R Gurando, Volodimyr V Shetelya, Nataliya V Layoch, Iurii O Mochalov
OBJECTIVE: The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity. PATIENTS AND METHODS: Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients. We assessed changes in total protein and its fractions, C-reactive protein (CRP), lysozyme, and immunoglobulins (A, M, and G) during three distinct time intervals: 1-3 days, 5-7 days, and 8-14 days after treatment initiation...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38028869/unveiling-therapeutic-potential-a-systematic-review-of-photobiomodulation-therapy-and-biological-dressings-for-diabetic-foot-ulcers
#25
REVIEW
Sina Karimpour, Mohammad Hussein Amirmotamed, Fariborz Rashno, Foozhan Tahmasebinia, Aliasghar Keramatinia, Fatemeh Fadaee Fathabadi, Hojjat Allah Abbaszadeh, Shahram Darabi
Introduction: Diabetes poses a global health challenge, giving rise to various complications, including diabetic foot ulcers (DFUs). DFUs, marked by ischemic ulcers susceptible to infection and amputation, underscore the urgency for innovative treatments. This study investigated the impact of photobiomodulation therapy (PBT) and autologous platelet gel (APG) on DFUs recovery. Methods: We systematically searched Web of Science, EMBASE, MEDLINE, Cochrane Library, Scopus, and Google Scholar (2015-2023) by using pertinent terms like "photobiomodulation therapy," "low level light therapy," and "platelet gel...
2023: Journal of Lasers in Medical Sciences
https://read.qxmd.com/read/37965319/case-report-labor-induced-coccydynia-associated-with-modic-i-changes-successfully-treated-with-platelet-rich-plasma
#26
Miloš Vuković, Igor Nosek, Jelena Vuković, Đorđe Ilić, Duško Kozić, Jasmina Boban
Imaging can aid in determining potential causes of coccygeal pain and therefore guide clinicians to carry out individualized treatment. We represent a case of postpartum coccydynia treated by platelet-rich plasma (PRP) which was assessed and followed by MRI. A primipara with uncomplicated labor developed coccygeal pain after delivery that significantly limited her postpartum recovery. On the first MR scan, recorded 6 months after delivery, there were edematous changes of the vertebral endplates of Co1-4 level (Modic type I) with the presence of pronounced precoccygeal venous drainage...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37914919/misdiagnosis-of-thrombotic-microangiopathy-in-the-emergency-department-a-multicenter-retrospective-study
#27
MULTICENTER STUDY
Isaure de Boisriou, Sami Ellouze, Christian Kassasseya, Anne-Laure Feral-Pierssens, Camille Gerlier, Anthony Chauvin, Sebastien Beaune, Evelyne Dubreucq, Laurent Pereira, Richard Chocron, Mehdi Khellaf, Éric Mariotte, Lara Zafrani, Olivier Peyrony
To estimate the rate of inappropriate diagnosis in patients who visited the ED with thrombotic microangiopathy (TMA) and to assess the factors and outcomes associated with emergency department (ED) misdiagnosis. Retrospective multicenter study of adult patients admitted to the intensive care unit (ICU) for TMA from 2012 to 2021 who had previously attended the ED for a reason related to TMA. Patient characteristics and outcomes were compared in a univariate analysis based on whether a TMA diagnosis was mentioned in the ED or not...
January 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/37854196/the-effect-of-growth-hormone-on-ovarian-function-recovery-in-a-mouse-model-of-ovarian-insufficiency
#28
JOURNAL ARTICLE
Su Mi Kim, Jung Young Yoo, Yeon Hee Hong, Jaewang Lee, Ji Hyang Kim, Jung Ryeol Lee
OBJECTIVES: To evaluate the effects and mechanisms of action of growth hormone (GH) in the recovery of ovarian function in ovarian insufficiency induced by cyclophosphamide (CP) in a mouse model. MATERIALS AND METHODS: After inducing ovarian insufficiency by administering 400 mg/kg of CP intraperitoneally to 6-week-old ICR mice, the mice were divided into four groups (control, CP, 1 mg/kg GH, and 2 mg/kg GH) with 10 mice in each group. GH was administered a week later for 7 days...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37808193/heparin-induced-thrombocytopenia-associated-with-low-molecular-weight-heparin-clinical-feature-analysis-of-cases-and-pharmacovigilance-assessment-of-the-faers-database
#29
JOURNAL ARTICLE
Leping Liu, Hong Zheng, Shanshan Chen, Shengfeng Wang, Minghua Yang
Background: Unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are commonly used anticoagulants for the management of arterial and venous thromboses. However, it is crucial to be aware that LMWH can, in rare cases, lead to a dangerous complication known as heparin-induced thrombocytopenia (HIT). The objective of this study was to evaluate the pharmacovigilance and clinical features of HIT associated with LMWH, as well as identify treatment strategies and risk factors to facilitate prompt management...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37748539/haplo-cord-transplantation-with-8mg-kg-anti-thymocyte-globulin-as-graft-versus-host-disease-prophylaxis-compared-to-haploidentical-transplantation-with-10mg-kg-anti-thymocyte-globulin-in-the-treatment-of-acute-leukemia
#30
JOURNAL ARTICLE
Fangfang Yuan, Gangping Li, Minghui Li, Xudong Wei, Yuewen Fu
BACKGROUND: Clinical outcomes of the transplantation strategy combined with a haploidentical stem cell graft and an unrelated umbilical cord blood unit (haplo-cord HSCT) with low-dose anti-thymocyte globulin as graft-versus-host disease prophylaxis for the treatment of acute leukemia (AL) remains unclear. OBJECTIVE: This study aimed to explore the clinical outcomes of haplo-cord HSCT in acute leukemia patients with the GVHD prevention strategy of 8 mg/kg ATG compared with haplo- transplantation with 10 mg/kg ATG...
September 23, 2023: Transplantation and cellular therapy
https://read.qxmd.com/read/37731501/the-influence-of-methotrexate-related-transporter-and-metabolizing-enzyme-gene-polymorphisms-on-peri-engraftment-syndrome-and-graft-versus-host-disease-after-haplo-hematopoietic-stem-cell-transplantation-in-pediatric-patients-with-malignant-hematological-diseases
#31
JOURNAL ARTICLE
Qi Ji, Yongping Zhang, Yixin Hu, Lixia Liu, Shanbo Cao, Li Gao, Bohan Li, Yuanyuan Tian, Lingjun Kong, Shuiyan Wu, Jing Ling, Peifang Xiao, Jun Lu, Jie Li, Yanhua Yao, Jiayue Qin, Shaoyan Hu
BACKGROUND: Methotrexate (MTX), utilized as a graft-versus-host disease (GvHD) prophylactic agent in allogeneic hematopoietic stem cell transplantation (allo-HSCT), has been proven to effectively decrease the occurrence of the peri-engraftment syndrome (Peri-ES) and acute GvHD (aGvHD). Changes in the pharmacodynamics of MTX are closely associated with gene polymorphisms in genes encoding drug-metabolizing enzymes and transporters. Nevertheless, the current studies mainly concentrate on leukemia or autoimmune diseases, and limited studies on allo-HSCT were reported...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37682171/effect-of-platelet-content-on-occurrence-and-prognosis-of-distal-radius-fracture
#32
JOURNAL ARTICLE
Danyang Ding, Hao Zhu, Meiliang Zheng, Chunbo Kang
Fractures of the distal radius are a common fracture with an increasing incidence. However, the underlying factors for distal radius fractures (DRFs) remain unclear. A total of 123 patients with distal radial fractures were recruited. To document clinical and follow-up data, and measure the levels of white blood cells, hemoglobin, platelets, and red blood cells in the bloodstream for qualitative observation of their expression effects within the human body, specifically assessing whether the magnitudes of these indicators are associated with potential factors influencing DRF...
September 8, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37664023/effectiveness-of-chemotherapy-using-bortezomib-combined-with-homoharringtonine-and-cytarabine-in-refractory-or-relapsed-acute-myeloid-leukemia-a-phase-ii-multicenter-prospective-clinical-trial
#33
JOURNAL ARTICLE
Chengtao Zhang, Da Gao, Xiaohong Wang, Xiuli Sun, Yan Yan, Yan Yang, Jingjing Zhang, Jinsong Yan
BACKGROUND: Refractory/relapsed acute myeloid leukemia (R/R AML) has unsatisfactory outcomes even after allogeneic hematopoietic stem cell transplantation. Long-term survival is mainly influenced by complete remission (CR) rates after induction therapies. OBJECTIVES: To investigate CR/CR with incomplete hematologic recovery (CRi) rates and adverse events with a new induction therapy (bortezomib, homoharringtonine, and cytarabine [BHA]) for patients with R/R AML...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37654997/evaluation-of-berberine-pellet-effect-on-clinical-recovery-time-in-covid-19-outpatients-a-pilot-clinical-trial
#34
JOURNAL ARTICLE
Soodabeh Omidvar Tehrani, Mahboobeh Ghasemzadeh Rahbardar, Kamran Shoorgashti, Mohammad Javad Dehghan Nayeri, Amir Hooshang Mohammadpour, Hossein Hosseinzadeh
OBJECTIVE: Severe disease onset of COVID-19 may result in alveolar injury and respiratory failure. Apoptosis and inflammation are the main causes of respiratory distress syndrome. Berberine is used in medicine as an analgesic, anti-asthmatic, anti-inflammatory, and antiviral. In the current investigation, the effect of berberine on COVID-19 outpatients was studied. MATERIALS AND METHODS: The present clinical trial was performed on 40 outpatients who were randomly assigned to berberine (300 mg, TID, 2 weeks) (n=19) or placebo groups (n=21)...
2023: Avicenna Journal of Phytomedicine
https://read.qxmd.com/read/37623667/composite-hydrogels-of-ultrasound-assisted-digested-formic-acid-decellularized-extracellular-matrix-and-sacchachitin-nanofibers-incorporated-with-platelet-rich-plasma-for-diabetic-wound-treatment
#35
JOURNAL ARTICLE
Chien-Ju Lin, Hong-Liang Lin, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen, Wei-Jie Cheng
In this study, an ultrasound-assisted digestion method of a formic acid-decellularized extracellular matrix (dECM) of porcine skin was developed and optimized to form UdECM hydrogels for diabetic wound healing. Results demonstrated that ultrasonication improved the extraction rate of collagen from dECM samples, preserved the collagen content of dECM, reduced residual cells, and extracted greater DNA contents. Scanning electron microscope (SEM) analyses were performed, which demonstrated the optimal porosity on the surface and density of the cross-section in the hydrogel structure, which could control the release of growth factors embedded in UdECM hydrogels at desirable rates to boost wound healing...
August 11, 2023: Journal of Functional Biomaterials
https://read.qxmd.com/read/37614713/platelet-rich-fibrin-improves-repair-and-regeneration-of-damaged-endometrium-in-rats
#36
JOURNAL ARTICLE
Lele Mao, XiaoXue Wang, Yu Sun, Mukun Yang, Xing Chen, Lei Cui, Wenpei Bai
PURPOSE: Intrauterine adhesion (IUA) is the most common cause of uterine infertility. This study aims to evaluate whether platelet-rich fibrin (PRF) treatment can stimulate damaged endometrium regeneration in rats. METHODS: First, hematoxylin and eosin (HE) staining, scanning and transmission electron microscopy, and ELISAs were used to evaluate the microstructure of PRF. Then, mechanical damage was used to establish an IUA rat model. A total of 40 SD female rats were randomized to three groups: PRF transplantation group, IUA group, and sham group...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37598660/safety-and-efficacy-of-flag-ida-based-therapy-combined-with-venetoclax-for-the-treatment-for-newly-diagnosed-and-relapsed-refractory-patients-with-aml-a-systematic-review
#37
JOURNAL ARTICLE
A Sherban, D Fredman, S Shimony, M Yeshurun, P Raanani, M Stahi, A Gafter-Gvili, O Wolach
Venetoclax (VEN) in combination with intensive chemotherapy (IC) is increasingly used to treat patients with high-risk acute myeloid leukemia (AML). We conducted a systematic review to assess the safety and efficacy outcomes of FLAG-IDA in combination with VEN. The primary safety outcome was infection rate; the primary efficacy outcome was response to treatment (composite complete remission (CRc) and overall response rate (ORR). Risk of bias was assessed according to the ROBINS-I tool. Six studies including 221 patients with newly-diagnosed (ND AML (n = 120)) and R/R AML (n = 101) disease, were included in this systematic review...
August 4, 2023: Leukemia Research
https://read.qxmd.com/read/37589942/safety-of-romiplostim-administered-immediately-after-cord-blood-transplantation-a-phase-1-trial
#38
JOURNAL ARTICLE
Naoki Kurita, Hidekazu Nishikii, Yumiko Maruyama, Yasuhito Suehara, Keiichiro Hattori, Tatsuhiro Sakamoto, Takayasu Kato, Yasuhisa Yokoyama, Naoshi Obara, Kazushi Maruo, Tomohiro Ohigashi, Hitomi Yamaguchi, Toshiro Iwamoto, Hideto Minohara, Ryota Matsuoka, Koichi Hashimoto, Mamiko Sakata-Yanagimoto, Shigeru Chiba
Graft failure and delayed hematopoietic recovery are the major limitations of cord-blood transplantation (CBT). Romiplostim, a thrombopoietin-receptor agonist, promotes megakaryopoiesis and multilineage hematopoiesis in aplastic anemia. The decreased number of hematopoietic stem cells in the early phase after CBT and aplastic anemia share certain characteristics. Therefore, we hypothesized that romiplostim administration immediately after CBT may promote multilineage hematopoietic recovery. We investigated the safety and preliminary efficacy of administering romiplostim a day after CBT...
August 17, 2023: Annals of Hematology
https://read.qxmd.com/read/37573353/self-anticoagulant-sponge-for-whole-blood-auto-transfusion-and-its-mechanism-of-coagulation-factor-inactivation
#39
JOURNAL ARTICLE
Tao Xu, Haifeng Ji, Lin Xu, Shengjun Cheng, Xianda Liu, Yupei Li, Rui Zhong, Weifeng Zhao, Jayachandran N Kizhakkedathu, Changsheng Zhao
Clinical use of intraoperative auto-transfusion requires the removal of platelets and plasma proteins due to pump-based suction and water-soluble anticoagulant administration, which causes dilutional coagulopathy. Herein, we develop a carboxylated and sulfonated heparin-mimetic polymer-modified sponge with spontaneous blood adsorption and instantaneous anticoagulation. We find that intrinsic coagulation factors, especially XI, are inactivated by adsorption to the sponge surface, while inactivation of thrombin in the sponge-treated plasma effectively inhibits the common coagulation pathway...
August 12, 2023: Nature Communications
https://read.qxmd.com/read/37537959/a-ready-to-use-purified-exosome-product-for-volumetric-muscle-loss-and-functional-recovery
#40
JOURNAL ARTICLE
Lorenzo Mazzucchelli, Aida Kaivan Sarcon, Chieh-Ting Tony Huang, Jialun Li, Charlotte E Berry, Matthew Thomas Houdek, Atta Behfar, Chunfeng Zhao, Steven L Moran
Large skeletal muscle defects due to trauma or following tumor extirpation can result in substantial functional impairment. Purified exosomes are now available clinically and have been used for wound healing. The objective of this study was to evaluate the regenerative capacity of commercially available exosomes on an animal model of volumetric muscle loss (VML) and potential translation to human muscle injury. An established VML rat model was used. In the in-vitro experiment, rat myoblasts were isolated and co-cultured with 5% purified exosome product (PEP) to validate uptake...
August 3, 2023: Tissue Engineering. Part A
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