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https://www.readbyqxmd.com/read/28449067/using-high-throughput-barcode-sequencing-to-efficiently-map-connectomes
#1
Ian D Peikon, Justus M Kebschull, Vasily V Vagin, Diana I Ravens, Yu-Chi Sun, Eric Brouzes, Ivan R Corrêa, Dario Bressan, Anthony M Zador
The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision-a 'connectome'-is based on imaging methods that are slow, labor-intensive and expensive. Here, we present SYNseq, a method for converting the connectome into a form that can exploit the speed and low cost of modern high-throughput DNA sequencing. In SYNseq, each neuron is labeled with a unique random nucleotide sequence-an RNA 'barcode'-which is targeted to the synapse using engineered proteins...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28448801/the-placental-factor-in-spontaneous-preterm-birth-in-twin-vs-singleton-pregnancies
#2
Eran Weiner, Ann Dekalo, Ohad Feldstein, Elad Barber, Letizia Schreiber, Jacob Bar, Michal Kovo
OBJECTIVE: The association between infection and inflammatory response in singleton preterm birth (PTB) is well established, yet, less is known about PTB in twins. We aimed to compare the placental component and pregnancy outcome in pregnancies complicated with PTB of singletons vs. twin deliveries. We hypothesized that due to different underlying mechanisms, placental inflammatory lesions will be more prevalent in placentas derived from singleton pregnancies than twins. STUDY DESIGN: Labor characteristics, neonatal outcome and placental histopathology reports of spontaneous PTB at 24-33(6)/7 weeks, from 1/2008-12/2015, were reviewed...
April 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28448341/a-nurse-directed-model-for-nitrous-oxide-use-during-labor
#3
(no author information available yet)
No abstract text is available yet for this article.
May 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28448331/a-nurse-directed-model-for-nitrous-oxide-use-during-labor
#4
Toni Pinyan, Kelly Curlee, Mellanie Keever, Kathleen M Baldwin
BACKGROUND: Nitrous oxide has a long history of use and has been well documented in the literature as a safe, effective, and inexpensive option for pain management in labor in other countries, but it is underused in the United States. LOCAL PROBLEM: Pain relief options for laboring women in rural community hospitals with a small perinatal service are limited due to lack of availability of in-house anesthesia coverage. METHOD: This quality improvement project involved development and implementation of a nurse-driven, self-administered, demand-flow nitrous oxide program as an option for pain relief for laboring women in a rural community hospital...
May 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28448321/chest-pain-during-cesarean-delivery-in-relation-to-anomalous-right-coronary-artery-a-case-report
#5
Blanca Tapia Salinas, Andrea Kollmann Camaiora, Estibaliz Alsina Marcos, Fernando Gilsanz
Chest pain during labor can have many etiologies, one of which is myocardial ischemia. We report a 38-year-old woman with American Society of Anesthesiology physical status I scheduled for elective cesarean delivery who experienced chest pain and electrocardiographic signs of myocardial ischemia immediately after carbetocin administration. Subsequent investigations revealed an aberrant right coronary artery originating from the left coronary sinus coursing between the aorta and the pulmonary artery. This was considered the likely cause of the patient's chest pain...
April 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28448223/the-alerrt-%C3%A2-instrument-a-quantitative-measure-of-the-effort-required-to-compromise-prescription-opioid-abuse-deterrent-tablets
#6
Edward J Cone, August R Buchhalter, Karsten Lindhardt, Torben Elhauge, Jeffrey M Dayno
BACKGROUND: US FDA guidance recommends measuring the degree of effort needed to manipulate abuse-deterrent (AD) opioids. The ALERRT(®) instrument (PinneyAssociates; Bethesda, MD) uses visual analog scales to assess the labor, effort, and resources necessary to physically compromise AD product candidates in standardized settings. OBJECTIVE: Use the ALERRT(®) instrument for testing morphine abuse-deterrent, extended-release, injection-molded tablets (ADER-IMT) 60 and 100 mg and the comparators immediate-release (IR) morphine sulfate 30 mg and extended-release (ER) morphine sulfate 60 mg...
May 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28448162/joblessness-and-lost-earnings-after-ards-in-a-1-year-national-multicenter-study
#7
Biren B Kamdar, Minxuan Huang, Victor D Dinglas, Elizabeth Colantuoni, Till M von Wachter, Ramona O Hopkins, Dale M Needham
RATIONALE: Following acute respiratory distress syndrome (ARDS), joblessness is common, but poorly understood. OBJECTIVES: To evaluate the timing of return to work following ARDS, and associated risk factors, lost earnings, and changes in healthcare coverage Methods: Over 12-month longitudinal follow-up, ARDS survivors from 43 U.S. ARDSNet hospitals provided employment and healthcare coverage data via structured telephone interviews. Factors associated with the timing of return to work were assessed using Fine and Gray regression analysis...
April 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28447873/employment-outcome-ten-years-after-moderate-to-severe-traumatic-brain-injury-a-prospective-cohort-study
#8
Erik Grauwmeijer, Majanka Heijenbrok-Kal, Iain Haitsma, Gerard Ribbers
The objective of this prospective cohort study was to evaluate the probability of employment and predictors of employment in patients with moderate to severe Traumatic Brain Injury (TBI) over 10 years follow-up. 113 patients (18-67 years) were included with follow-up measurements 3, 6, 12, 18, 24, 36 months and ten years after TBI. Potential predictors of employment probability included patient characteristics, injury severity factors, functional outcome measured at discharge from the hospital with the Glasgow Outcome Scale (GOS), Barthel Index (BI), Functional Independence Measure (FIM), and the Functional Assessment Measure (FAM)...
April 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28447838/in-defense-of-commitment-the-curative-power-of-violated-expectations
#9
Sandra L Murray, Veronica M Lamarche, Sarah Gomillion, Mark D Seery, Cheryl Kondrak
A new model of commitment defense in romantic relationships is proposed. It assumes that relationships afford a central resource for affirming meaning and purpose in the world. Consequently, violating expectations about the world outside the relationship can precipitate commitment defense inside the relationship. A meta-analysis of 5 experiments, 2 follow-up correlational studies, and a longitudinal study of the transition to first parenthood supported the model. Experimentally violating conventional expectations about the world (e...
April 27, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28447275/risk-factors-for-shoulder-dystocia-the-impact-of-mother-s-race-and-ethnicity
#10
Jennifer Gaudet Hefele, Palmira Santos, Grant Ritter, Neha Varma, Ann Hendrich
Shoulder dystocia is a rare but severe birth trauma where the neonate's shoulders fail to deliver after delivery of the head. Failure to deliver the shoulders quickly can lead to severe, long-term injury to the infant, including nerve injury, skeletal fractures, and potentially death. This observational study examined shoulder dystocia risk factors by race and ethnicity using a sample of 19,236 pregnant women who presented for labor and delivery from July 1, 2010 until June 30, 2013 at five locations. Multivariate analyses were used to identify risk factors associated with shoulder dystocia occurrence in racial/ethnic groups with high incidence rates...
April 26, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28446997/endoscopic-submucosal-dissection-and-endoscopic-mucosal-resection-for-early-stage-esophageal-cancer
#11
REVIEW
Bo Ning, Mohamed M Abdelfatah, Mohamed O Othman
Mortality from esophageal cancer remains high despite advances in medical therapy. Although the incidence of squamous cell carcinoma of the esophagus remains unchanged, the incidence of the esophageal adenocarcinoma has increased over time. Gastroesophageal reflux disease (GERD and obesity are contributing factors to the development of Barrett's esophagus and subsequent development of adenocarcinoma. Early recognition of the disease can lead to resection of esophageal cancer prior to the development of lymphovascular invasion...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28446422/web-based-medical-appointment-systems-a-systematic-review
#12
Peng Zhao, Illhoi Yoo, Jaie Lavoie, Beau James Lavoie, Eduardo Simoes
BACKGROUND: Health care is changing with a new emphasis on patient-centeredness. Fundamental to this transformation is the increasing recognition of patients' role in health care delivery and design. Medical appointment scheduling, as the starting point of most non-urgent health care services, is undergoing major developments to support active involvement of patients. By using the Internet as a medium, patients are given more freedom in decision making about their preferences for the appointments and have improved access...
April 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28445702/an-early-history-of-anesthesia-in-labor
#13
Mary E Gibson
Fear of pain often overshadows childbirth, and each woman must decide whether to receive anesthesia to combat labor pain. Historically, this choice resulted in unintended consequences and marked the beginnings of medical interventions in labor and birth. The purpose of this article is to trace the use of anesthesia in childbirth from the mid-19th to the mid-20th centuries and to explore its influence on childbearing women and nurses.
April 23, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28444530/-that-s-kind-of-one-of-our-jobs-sexual-activity-as-a-form-of-care-work-among-women-with-sexual-difficulties
#14
Amy Braksmajer
Willing engagement in unwanted or undesired sexual activity, often associated with fulfilling a partner's needs or sustaining intimate relationships, is common. Acquiescence with undesired sexual activity can be conceptualized as sexual care work, that is, domestic "labor" that women undertake with the goal of caring for their partners' well-being. Drawing on interviews with 53 women with dyspareunia (pain experienced during intercourse) and low desire, the aim of this study was to examine how women with sexual difficulties engage in sexual care work, the implications of the inability to perform such work for gender identity, and the ways in which sexual care work may blur the lines between women's perceptions of coercion and consent...
April 25, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28444286/screening-for-preeclampsia-us-preventive-services-task-force-recommendation-statement
#15
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ failure. Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth weight, and stillbirth. Many of the complications associated with preeclampsia lead to early induction of labor or cesarean delivery and subsequent preterm birth...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28443994/relationship-between-psychosocial-stress-dimensions-and-salivary-cortisol-in-military-police-officers
#16
Juliana Petri Tavares, Liana Lautert, Tânia Solange Bosi de Souza Magnago, Angélica Rosat Consiglio, Daiane Dal Pai
OBJECTIVE: to analyze the relationship between psychosocial stress dimensions and salivary cortisol in military police officers. METHOD: cross-sectional and analytical study with 134 military police officers. The Effort-Reward Imbalance (ERI) Model scale has been used to assess psychosocial stress. Salivary cortisol was collected in three samples. The following tests were used: Student's t-test, Mann-Whitney, ANOVA, Bonferroni, Kruskal-Wallis and Dunn. Pearson and Spearman correlation methods were used, as well as multiple linear regression...
April 20, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28442598/ethylene-regulates-differential-growth-via-big-arf-gef-dependent-post-golgi-secretory-trafficking-in-arabidopsis
#17
Kristoffer Jonsson, Yohann Boutté, Rajesh Kumar Singh, Delphine Gendre, Rishikesh Bhalerao
During early seedling development, the shoot apical meristem is protected from damage as the seedling emerges from soil by the formation of apical hook. Hook formation requires differential growth across the epidermis below the meristem in the hypocotyl. The plant hormones ethylene and auxin play key roles during apical hook development by controlling differential growth. We provide genetic and cell biological evidence for the role of ADP-ribosylation factor 1 (ARF1)-GTPase and its effector ARF-guanine-exchange factors (GEF)s of the BFA-inhibited GEF (BIG) family and GNOM in ethylene- and auxin-mediated control of hook development...
April 24, 2017: Plant Cell
https://www.readbyqxmd.com/read/28442165/technical-tips-to-enhance-micrografting-results-in-burn-surgery
#18
Si Jack Chong, Abby Choke, Bien-Keem Tan
The lack of autograft donor site is one of the greatest limiting factors for the treatment of extensive burn. Micrografting is an important revolution in burn surgery where autografts are cut into small pieces for wide and rapid coverage of burn wound. Our early experiences with the current standard micrografting technique were fraught with poor graft take as well being time and labor intensive. We have improvised our technique, where we combined the use of allograft to serve as a carrier for the micrograft...
April 22, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28439544/quantifying-the-negative-impact-of-brain-drain-on-the-integration-of-european-science
#19
Omar A Doria Arrieta, Fabio Pammolli, Alexander M Petersen
The 2004/2007 European Union (EU) enlargement by 12 member states offers a unique opportunity to quantify the impact of EU efforts to expand and integrate the scientific competitiveness of the European Research Area (ERA). We apply two causal estimation schemes to cross-border collaboration data extracted from millions of academic publications from 1996 to 2012, which are disaggregated across 14 subject areas and 32 European countries. Our results illustrate the unintended consequences following the 2004/2007 enlargement, namely, its negative impact on cross-border collaboration in science...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28439436/programmed-intermittent-epidural-boluses-pieb-for-maintenance-of-labor-analgesia-an-incremental-step-before-the-next-paradigm-shift
#20
Brendan Carvalho, Edward T Riley
No abstract text is available yet for this article.
April 2017: Turkish Journal of Anaesthesiology and Reanimation
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