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https://www.readbyqxmd.com/read/28736436/heterogeneity-in-tuberculosis
#1
REVIEW
Anthony M Cadena, Sarah M Fortune, JoAnne L Flynn
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results in a range of clinical presentations in humans. Most infections manifest as a clinically asymptomatic, contained state that is termed latent TB infection (LTBI); a smaller subset of infected individuals present with symptomatic, active TB. Within these two seemingly binary states, there is a spectrum of host outcomes that have varying symptoms, microbiologies, immune responses and pathologies. Recently, it has become apparent that there is diversity of infection even within a single individual...
July 24, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28734517/tuberculosis-in-children
#2
REVIEW
Tania A Thomas
Mycobacterium tuberculosis is the leading cause of death worldwide from a single bacterial pathogen. The World Health Organization estimates that annually 1 million children have tuberculosis (TB) disease and many more harbor a latent form. Accurate estimates are hindered by under-recognition and challenges in diagnosis. To date, an accurate diagnostic test to confirm TB in children does not exist. Treatment is lengthy but outcomes are generally favorable with timely initiation. With the End TB Strategy, there is an urgent need for improved diagnostics and treatment to prevent the unnecessary morbidity and mortality from TB in children...
August 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28733429/proteogenomic-analysis-and-discovery-of-immune-antigens-in-mycobacterium-vaccae
#3
Jianhua Zheng, Lihong Chen, Liguo Liu, Haifeng Li, Bo Liu, Dandan Zheng, Tao Liu, Jie Dong, Lilian Sun, Yafang Zhu, Jian Yang, Xiaobing Zhang, Qi Jin
Tuberculosis (TB) is one of the leading causes of death worldwide, especially in developing countries. Neonatal BCG vaccination occurs in various regions, but the level of protection varies in different populations. Recently, Mycobacterium vaccae is found to be an immunomodulating therapeutic agent that could confer a significant level of protection against TB. It is the only vaccine in a phase III trial from WHO to assess its efficacy and safety in preventing TB disease in people with latent TB infection. However, the mechanism of immunotherapy of M...
July 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28730751/tuberculosis-and-biologics-in-rheumatology-india-a-special-situation
#4
REVIEW
Rohini Handa, Sundeep Upadhyaya, Sanjiv Kapoor, Ramesh Jois, Bimlesh D Pandey, Anuj K Bhatnagar, Ashwani Khanna, Vishal Goyal, Kamal Kumar
India has a huge patient burden of rheumatic diseases (RDs) including rheumatoid arthritis. The use of biologics has transformed the treatment paradigm for RD; however, biologic treatment-related infections (especially tuberculosis [TB]) are an area of potential concern for TB-endemic nations like India. Anti-tumor necrosis factor (TNF) therapy impairs the physiological TNF-mediated signaling and may cause reactivation and dissemination of latent TB infection (LTBI). Careful screening is, thus, crucial in RD patients who are about to commence anti-TNF treatment...
July 21, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28730222/tuberculosis-and-its-particularities-in-romania-and-worldwide
#5
Floarea Mimi NiŢu, Mihai Olteanu, Costin Teodor Streba, Gabriela Jimborean, Paraschiva Postolache, Milena Adina Man, Antigona Carmen Trofor, Roxana Maria Nemeş, Livia Dragonu, Mădălina Olteanu
Tuberculosis (TB) is a global health issue, with a rising incidence since the beginning of this century. It poses a severe mortality risk and also poses a serious economic risk as it reduces the working capacity of an individual in the most productive part of life. Developing countries face widespread tuberculosis infection - up to 95% of all cases and 98% of deaths, respectively. It is a highly contagious infectious disease caused by Mycobacterium tuberculosis (the Koch bacillus) that can be contracted from either humans or animal hosts...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729186/-tuberculosis-treatment-for-children-an-update
#6
María José Mellado Peña, Begoña Santiago García, Fernando Baquero-Artigao, David Moreno Pérez, Roi Piñeiro Pérez, Ana Méndez Echevarría, José Tomás Ramos Amador, David Gómez-Pastrana Durán, Antoni Noguera Julian
Tuberculosis (TB) is the most important infectious disease all over the world, with a high morbidity and mortality. Pediatric tuberculosis has been a neglected epidemic, due to the difficulties in assessing its global impact, reduced incidence and lower infectivity compared to adults. In 2015, the WHO reported 1 million cases of paediatric TB and 169,000 deaths. In Europe, the emergence of MDR TB is a major concern, representing 16% of the new diagnosis in Eastern Europe. In 2014, it was estimated that about 219,000 children were infected by MDR-TB-strains in Europe, and 2,120 developed the disease...
July 17, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28728346/suggestions-for-promoting-evidence-based-public-health-in-korea
#7
Jong-Myon Bae
The Public Health (EBPH) is defined as a decision-making in the domain of public health using current best evidences. Debates about the latent tuberculosis infection control program suggested by the Korea Centers for Disease Control and Prevention in 2017 bring the need for promoting EBPH. To do this, three strategies were suggested as following: drawing some necessary evidences by evaluating policy-evidence gaps, delivering good quality and relevant evidences timely by conducting systematic reviews and adapting public health guidelines, and making the value-driven decisions by training and educating public health policy makers...
July 19, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28720766/predicting-susceptibility-to-tuberculosis-based-on-gene-expression-profiling-in-dendritic-cells
#8
John D Blischak, Ludovic Tailleux, Marsha Myrthil, Cécile Charlois, Emmanuel Bergot, Aurélien Dinh, Gloria Morizot, Olivia Chény, Cassandre Von Platen, Jean-Louis Herrmann, Roland Brosch, Luis B Barreiro, Yoav Gilad
Tuberculosis (TB) is a deadly infectious disease, which kills millions of people every year. The causative pathogen, Mycobacterium tuberculosis (MTB), is estimated to have infected up to a third of the world's population; however, only approximately 10% of infected healthy individuals progress to active TB. Despite evidence for heritability, it is not currently possible to predict who may develop TB. To explore approaches to classify susceptibility to TB, we infected with MTB dendritic cells (DCs) from putatively resistant individuals diagnosed with latent TB, and from susceptible individuals that had recovered from active TB...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716677/incidence-of-active-tuberculosis-in-individuals-with-latent-tuberculosis-infection-in-rural-china-follow-up-results-of-a-population-based-multicentre-prospective-cohort-study
#9
Lei Gao, Xiangwei Li, Jianmin Liu, Xinhua Wang, Wei Lu, Liqiong Bai, Henan Xin, Haoran Zhang, Hengjing Li, Zongde Zhang, Yu Ma, Mufei Li, Boxuan Feng, Jiang Du, Hongtao Sui, Rong Zhao, Haoxiang Su, Shouguo Pan, Ling Guan, Fei Shen, Jian He, Shumin Yang, Hongyan Si, Xu Cheng, Zuhui Xu, Yunhong Tan, Tianzhu Chen, Weiguo Xu, Hong Peng, Zhijian Wang, Tao Zhu, Xiaoyou Chen, Xinhua Zhou, Xueling Guan, Qi Jin
BACKGROUND: The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy. However, national guidelines on latent tuberculosis infection testing and treatment have not yet been developed in China. Here, we present the results from the 2-year follow-up of a study that aimed to track the development of active disease in individuals with latent tuberculosis infection, identify priority populations for latent infection management, and explore the most suitable latent infection diagnostic approach...
July 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28710848/breaking-transmission-with-vaccines-the-case-of-tuberculosis
#10
Jesus Gonzalo-Asensio, Nacho Aguilo, Dessislava Marinova, Carlos Martin
Members of the Mycobacterium tuberculosis complex (MTBC) have evolved causing tuberculosis (TB) in different mammalian hosts. MTBC ecotypes have adapted to diverse animal species, with M. bovis being the most common cause of TB in livestock. Cattle-to-human transmission of M. bovis through ingestion of raw milk was common before introduction of the pasteurization process. TB in humans is mainly caused by M. tuberculosis. This bacterium is considered a genetically clonal pathogen that has coevolved with humans due to its ability to manipulate and subvert the immune response...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28694178/medicinal-plants-used-in-the-treatment-of-tuberculosis-ethnobotanical-and-ethnopharmacological-approaches
#11
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Zorica Z Stojanović-Radić, Patrick Valere Tsouh Fokou, Marzieh Sharifi-Rad, Gail B Mahady, Majid Sharifi-Rad, Mohammad-Reza Masjedi, Temitope O Lawal, Seyed Abdulmajid Ayatollahi, Javid Masjedi, Razieh Sharifi-Rad, William N Setzer, Mehdi Sharifi-Rad, Farzad Kobarfard, Atta-Ur Rahman, Muhammad Iqbal Choudhary, Athar Ata, Marcello Iriti
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-resistant tuberculosis, mainly due to low adherence to prescribed therapies or inefficient healthcare structures, requires at least 20months of treatment with second-line, more toxic and less efficient drugs, i...
July 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28670225/management-of-ulcerative-colitis-in-taiwan-consensus-guideline-of-the-taiwan-society-of-inflammatory-bowel-disease
#12
REVIEW
Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chia-Tung Shun, Yuk-Ming Tsang, Cheng-Yi Wang, Horng-Yuan Wang, Meng-Tzu Weng, Deng-Chyang Wu, Wen-Chieh Wu, Hsu-Heng Yen, Jau-Min Wong
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28667275/tuberculosis-infection-in-rural-labor-migrants-in-shenzhen-china-emerging-challenge-to-tuberculosis-control-during-urbanization
#13
Xiangwei Li, Qianting Yang, Boxuan Feng, Henan Xin, MingXia Zhang, Qunyi Deng, Guofang Deng, Wanshui Shan, Jianrong Yue, Haoran Zhang, Mufei Li, Hengjing Li, Qi Jin, Xinchun Chen, Lei Gao
During China's urbanization process, rural labor migrants have been suggested to be one important bridge population to change urban-rural distribution on tuberculosis (TB) burden. Aiming to estimate the prevalence of TB infection and to track the active disease development in rural labor migrants, a prospective study was conducted in Shenzhen city, southern China. TB infection was detected using interferon-γ release assay (IGRA). Here we mainly report the characteristics of TB infection in the study population based on the baseline survey...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28659881/rna-profiling-analysis-of-the-serum-exosomes-derived-from-patients-with-active-and-latent-mycobacterium-tuberculosis-infection
#14
Lingna Lv, Cuidan Li, Xiuli Zhang, Nan Ding, Tianshu Cao, Xinmiao Jia, Jinghui Wang, Liping Pan, Hongyan Jia, Zihui Li, Ju Zhang, Fei Chen, Zongde Zhang
Tuberculosis (TB) has exceeded HIV as the most lethal infectious disease globally for two consecutive years. Moreover, one third of the world's population is estimated to have latent tuberculosis infection (LTBI). This is mainly because of difficulties associated with diagnosis and treatment for both TB and LTBI patients. Exosomes provide a promising research tool for TB diagnosis and treatment because they are released from various cells containing valuable biochemical information related to disease. In this study, we performed RNA-sequencing analysis on exosomes derived from clinical specimens of healthy controls (HC), active tuberculosis (ATB), and LTBI patients...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28651949/%C3%AE-%C3%AE-t-cell-function-is-inhibited-in-end-stage-renal%C3%A2-disease-and-impacted-by-latent-tuberculosis%C3%A2-infection
#15
Jennifer A Juno, Jillian L M Waruk, Angela Harris, Christine Mesa, Carmen Lopez, Joe Bueti, T Blake Ball, Sandra A Kiazyk
Patients with end-stage renal disease (ESRD) are at elevated risk of acquiring infectious diseases, including tuberculosis (TB). Inflammation and uremia negatively impact immune function in this population, but specific pathways involved in TB immunity have not been identified. Although γδ T cells are known to contribute to protection from TB, their phenotype and function in patients with ESRD is relatively unknown. To determine this we recruited 20 patients with and 20 without ESRD (controls), with or without latent TB infection to assess γδ T cell frequency, surface phenotype, and cytokine production by flow cytometry in response to stimulation...
June 24, 2017: Kidney International
https://www.readbyqxmd.com/read/28646966/a-systematic-approach-to-diagnosing-intra-thoracic-tuberculosis-in-children
#16
Carlos M Perez-Velez, Claudia L Roya-Pabon, Ben J Marais
Children suffer a huge and often underappreciated burden of disease in tuberculosis (TB) endemic countries. Major hurdles include limited awareness among health care workers, poor integration of TB into maternal and child health approaches, diagnostic difficulties and a lack of child-friendly treatment options. Accurate disease diagnosis is particularly difficult in young and vulnerable children who tend to develop paucibacillary disease and are unable to produce an expectorated sputum sample. In addition, access to chest radiography is problematic in resource-limited settings...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646434/performance-of-quantiferon-%C3%A2-tb-gold-in-tube-assay-in-children-receiving-disease-modifying-anti-rheumatic-drugs
#17
Francesca Gabriele, Maria Trachana, Maria Simitsopoulou, Polixeni Pratsidou-Gertsi, Elias Iosifidis, Zoi Dorothea Pana, Emmanuel Roilides
BACKGROUND: To evaluate the performance of the Quantiferon(®)-TB Gold In-Tube (QFT-IT) interferon (IFN)-γ assay for the detection of latent tuberculosis infection (LTBI) in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern Greece. METHODS: A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis factor (TNF)-α treatment] were tested using Mantoux tuberculin skin test (TST) and QFT-IT...
June 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28628015/latent-tuberculosis-potential-biomarkers-reactivation-of-infection
#18
I Pantsulaia, N Kikodze, T Chikovani
Tuberculosis continues to be one of the most important infectious causes of death worldwide. Despite substantial investments and progress made in expansion of directly observed therapy short course (DOTS) strategy, improved treatment completion rates and inadequate case detection remains a major obstacle for global control of Tuberculosis. The global case detection rate has increased from 28% to 60%. However, it is estimated that approximately 50% of patients with tuberculosis are still not diagnosed or treated appropriately...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28609574/factors-associated-with-the-choice-of-the-first-biologic-in-psoriasis-real-life-analysis-from-the-psobioteq-cohort
#19
Emilie Sbidian, Caroline Giboin, Hervé Bachelez, Carle Paul, Marie Beylot-Barry, Alain Dupuy, Manuelle Viguier, Jean-Philippe Lacour, Jean-Luc Schmutz, Pierre Bravard, Emmanuel Mahé, Nathalie Beneton, Laurent Misery, Emmanuel Delaporte, Philippe Modiano, Sébastien Barbarot, Elodie Regnier, Denis Jullien, Marie-Aleth Richard, Pascal Joly, Florence Tubach, Olivier Chosidow
BACKGROUND: Decision making is a complex process. The aim of our study was to assess factors associated with the choice of the first biological treatment in patients with moderate-to-severe psoriasis. METHODS: Data on all patients included in the French prospective, observational, cohort, Psobioteq and initiating a first biologic prescription between July 2012 and July 2016 were analysed. Demographic information and clinical features were collected during routine clinical assessments by the dermatology team at the recruiting centres using a standardized case report form...
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28605520/serial-tuberculosis-screening-in-inflammatory-bowel-disease-patients-under-anti-tnf%C3%AE-therapy
#20
Cândida Abreu, Joana Afonso, Cláudia Camila Dias, Rogério Ruas, António Sarmento, Fernando Magro
Background and aims: One of the adverse effects of the tumour necrosis factor-α monoclonal antibodies for the treatment of immune-mediated inflammatory diseases is a higher propensity for tuberculosis development. The aim of this study was to explore the utility and sensitivity of serial tuberculosis screening during anti-TNFα treatment. Methods: A cohort of 46 inflammatory bowel disease patients on infliximab was prospectively recruited and followed for 26 months...
June 9, 2017: Journal of Crohn's & Colitis
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