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https://www.readbyqxmd.com/read/28449041/periodontal-disease-tooth-loss-and-cancer-risk
#1
Dominique S Michaud, Zhuxuan Fu, Jian Shi, Mei Chung
Periodontal disease, which includes gingivitis and periodontitis, is highly prevalent in adults and disease severity increases with age. The relationship between periodontal disease and oral cancer has been examined for several decades, but there is increasing interest in the link between periodontal disease and overall cancer risk, with systemic inflammation serving as the main focus for biological plausibility. Numerous case-control studies have addressed the role of oral health in head and neck cancer, and several cohort studies have examined associations with other types of cancers over the past decade...
April 25, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28448665/trends-in-the-incidence-prevalence-and-survival-outcomes-in-patients-with-neuroendocrine-tumors-in-the-united-states
#2
Arvind Dasari, Chan Shen, Daniel Halperin, Bo Zhao, Shouhao Zhou, Ying Xu, Tina Shih, James C Yao
Importance: The incidence and prevalence of neuroendocrine tumors (NETs) are thought to be rising, but updated epidemiologic data are lacking. Objective: To explore the evolving epidemiology and investigate the effect of therapeutic advances on survival of patients with NETs. Design, Setting, and Participants: A retrospective, population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results (SEER) program was conducted to evaluate 64 971 patients with NETs from 1973 to 2012...
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28448615/emphysema-is-associated-with-thoracic-vertebral-bone-attenuation-on-chest-ct-scan-in-hiv-infected-individuals
#3
Alycia Petraglia, Joseph K Leader, Matthew Gingo, Meghan Fitzpatrick, John Ries, Cathy Kessinger, Lorrie Lucht, Danielle Camp, Alison Morris, Jessica Bon
BACKGROUND: Age-related chronic diseases are prevalent in HIV-infected persons in the antiretroviral therapy (ART) era. Bone mineral density (BMD) loss and emphysema have separately been shown to occur at a younger age and with lesser risk exposure in HIV-infected compared to HIV-uninfected individuals. In non-HIV infected smokers, emphysema has been shown to independently predict low BMD. We hypothesized that emphysema would independently associate with thoracic vertebral bone attenuation, a surrogate for bone mineral density, in HIV-infected individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28444364/effect-of-rituximab-on-the-progression-of-rheumatoid-arthritis-related-interstitial-lung-disease-10-years-experience-at-a-single-centre
#4
Md Yuzaiful Md Yusof, Angela Kabia, Michael Darby, Giovanni Lettieri, Paul Beirne, Edward M Vital, Shouvik Dass, Paul Emery
Objective.: To evaluate the effect of rituximab (RTX) in patients with RA-related interstitial lung disease (RA-ILD) and identify factors associated with outcome after treatment. Methods.: An observational study of patients with RA-ILD was conducted from a cohort of RTX-treated RA patients in a single centre for >10 years. Progression was defined by any of the following: a decrease of pre-RTX forced vital capacity (FVC) >10% or diffusion capacity of carbon monoxide (DLCO) >15% predicted, worsening of the ILD score or death from progressive ILD...
April 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/28443323/prevalence-of-ctr1-and-ercc1-polymorphisms-and-response-of-biliary-tract-cancer-to-gemcitabine-platinum-chemotherapy
#5
Skolchart Pongmaneratanakul, Suebpong Tanasanvimon, Thitima Pengsuparp, Nutthada Areepium
Purpose: Biliary tract cancer (BTC)is an aggressive disease with a poor prognosis. Most patients are diagnosed at an advanced stage for which curative surgery is not possible and gemcitabine-platinum chemotherapy is the treatment of choice for advanced cases. Several studies had focused on biomarkers to predict response from platinum drugs in lung cancer, but information is limited for BTC. In this study, two single nucleotide polymorphisms (SNPs) in the copper transporter (CTR1) and excision repair cross-complementary group 1 (ERCC1) genes were investigated as predictive biomarkers of objective response to gemcitabine-platinum...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28443245/overexpression-of-the-atpase-inhibitory-factor-1-favors-a-non-metastatic-phenotype-in-breast-cancer
#6
Lucía García-Ledo, Cristina Nuevo-Tapioles, Carmen Cuevas-Martín, Inmaculada Martínez-Reyes, Beatriz Soldevilla, Lucía González-Llorente, José M Cuezva
Partial suppression of mitochondrial oxidative phosphorylation and the concurrent activation of aerobic glycolysis is a hallmark of proliferating cancer cells. Overexpression of the ATPase inhibitory factor 1 (IF1), an in vivo inhibitor of the mitochondrial ATP synthase, is observed in most prevalent human carcinomas favoring metabolic rewiring to an enhanced glycolysis and cancer progression. Consistently, a high expression of IF1 in hepatocarcinomas and in carcinomas of the lung, bladder, and stomach and in gliomas is a biomarker of bad patient prognosis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28442310/copd-osa-overlap-syndrome-evolving-evidence-regarding-epidemiology-clinical-consequences-and-management
#7
REVIEW
Walter T McNicholas
Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of co-existing OSA in that the increased lung volumes and low body mass index (BMI) associated with the predominant emphysema phenotype protects against OSA, whereas the higher likelihood of peripheral edema and increased BMI associated with the predominant chronic bronchitis phenotype promotes OSA...
April 22, 2017: Chest
https://www.readbyqxmd.com/read/28442234/impact-of-restrictive-lung-disorder-on-cardiovascular-mortality-in-a-general-population-the-yamagata-takahata-study
#8
Yuki Honda, Tetsu Watanabe, Yoko Shibata, Yoichiro Otaki, Shinpei Kadowaki, Taro Narumi, Tetsuya Takahashi, Daisuke Kinoshita, Miyuki Yokoyama, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Sumito Inoue, Takuya Miyamoto, Tsuneo Konta, Ryo Kawasaki, Makoto Daimon, Takeo Kato, Yoshiyuki Ueno, Takamasa Kayama, Isao Kubota
BACKGROUND: Obstructive lung disorder (OLD) is known to be associated with cardiovascular disease. However, the impact of restrictive lung disorder (RLD) on cardiovascular mortality has not been fully investigated in the apparently healthy general population. OBJECTIVES: To clarify whether RLD is associated with cardiovascular mortality in the general population. METHODS AND RESULTS: This community-based cohort study included 3247 subjects who participated in an annual health check in Takahata...
April 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28440535/socioeconomic-status-and-its-relationship-to-chronic-respiratory-disease
#9
Sonu Sahni, Ankoor Talwar, Sameer Khanijo, Arunabh Talwar
Socioeconomic status (SES) is defined as an individual's social or economic standing, and is a measure of an individual's or family's social or economic position or rank in a social group. It is a composite of several measures including income, education, occupation, location of residence or housing. Studies have found a lower SES has been linked to disproportionate access to health care in many diseases. There is emerging data in pulmonary diseases such as COPD, asthma, cystic fibrosis, pulmonary hypertension and other chronic respiratory conditions that allude to a similar observation noted in other chronic diseases...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28440530/comorbidity-in-patients-undergoing-surgery-for-lung-cancer-do-we-have-an-adequate-tool-to-assess-it
#10
Marta Lembicz, Piotr Gabryel, Beata Brajer-Luftmann, Wojciech Dyszkiewicz, Halina Batura-Gabryel
INTRODUCTION: In the recent years comorbidity has been discussed as a factor affecting therapeutic decisions, the course of treatment, and prognosis of patients with lung cancer. The aim of the study was 1. to evaluate the occurrence of comorbidities in patients with lung cancer undergoing surgery, and 2. to investigate the utility of Charlson Comorbidity Index (CCI) and Simplified Comorbidity Score (SCS) for preoperative evaluation of Polish patients with lung cancer. MATERIAL AND METHODS: The retrospective study included 476 patients with lung cancer, who underwent surgical treatment...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28432700/serum-h-ficolin-levels-clinical-association-with-interstitial-lung-disease-in-patients-with-systemic-sclerosis
#11
Takuya Miyagawa, Yoshihide Asano, Yuka de Mestier, Ryosuke Saigusa, Takashi Taniguchi, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Ayumi Yoshizaki, Tomomitsu Miyagaki, Makoto Sugaya, Shinichi Sato
Ficolins, a group of oligomeric lectins consisting of three isoforms (H-, L- and M-ficolin), contribute to innate immunity via activating the complement pathway and/or acting directly as opsonins against pathogens and apoptotic cells. Because apoptotic cells likely drive the development of systemic sclerosis (SSc) partly through innate immunity, we assessed the clinical association of serum H-ficolin levels in SSc patients. Despite no difference in serum H-ficolin levels between SSc and control subjects, SSc patients with decreased serum H-ficolin levels tended to have a higher prevalence of interstitial lung disease (ILD)...
April 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28432286/the-breathing-thinking-functioning-clinical-model-a-proposal-to-facilitate-evidence-based-breathlessness-management-in-chronic-respiratory-disease
#12
REVIEW
Anna Spathis, Sara Booth, Catherine Moffat, Rhys Hurst, Richella Ryan, Chloe Chin, Julie Burkin
Refractory breathlessness is a highly prevalent and distressing symptom in advanced chronic respiratory disease. Its intensity is not reliably predicted by the severity of lung pathology, with unhelpful emotions and behaviours inadvertently exacerbating and perpetuating the problem. Improved symptom management is possible if clinicians choose appropriate non-pharmacological approaches, but these require engagement and commitment from both patients and clinicians. The Breathing Thinking Functioning clinical model is a proposal, developed from current evidence, that has the potential to facilitate effective symptom control, by providing a rationale and focus for treatment...
April 21, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28427314/capturing-complexity-in-pulmonary-system-modelling
#13
Alys R Clark, Haribalan Kumar, Kelly Burrowes
Respiratory disease is a significant problem worldwide, and it is a problem with increasing prevalence. Pathology in the upper airways and lung is very difficult to diagnose and treat, as response to disease is often heterogeneous across patients. Computational models have long been used to help understand respiratory function, and these models have evolved alongside increases in the resolution of medical imaging and increased capability of functional imaging, advances in biological knowledge, mathematical techniques and computational power...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28424927/development-of-new-extra-glandular-manifestations-or-associated-auto-immune-diseases-after-establishing-the-diagnosis-of-primary-sj%C3%A3-gren-s-syndrome-a-long-term-study-of-the-antonius-nieuwegein-sj%C3%A3-gren-ans-cohort
#14
E J Ter Borg, J C Kelder
To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015...
April 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28424361/computed-tomographic-findings-in-subjects-who-died-from-respiratory-disease-in-the-national-lung-screening-trial
#15
Esther Pompe, Pim A de Jong, David A Lynch, Nikolas Lessmann, Ivana Išgum, Bram van Ginneken, Jan-Willem J Lammers, Firdaus A A Mohamed Hoesein
We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28423031/comorbidities-of-rheumatoid-arthritis-results-from-the-korean-national-health-and-nutrition-examination-survey
#16
Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28421172/aspiration-risk-and-respiratory-complications-in-patients-with-esophageal-atresia
#17
REVIEW
Thomas Kovesi
Chronic, long-term respiratory morbidity (CRM) is common in patients with a history of repaired congenital esophageal atresia, typically associated with tracheoesophageal fistula (EA/TEF). EA/TEF patients are at high risk of having aspiration, and retrospective studies have associated CRM with both recurrent aspiration and atopy. However, studies evaluating the association between CRM in this population and either aspiration or atopy have reported conflicting results. Furthermore, CRM in this population may be due to other related conditions as well, such as tracheomalacia and/or recurrent infections...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28416930/what-are-the-prevalence-of-abdominal-aortic-aneurysm-in-patients-with-chronic-obstructive-pulmonary-diseases-and-the-characteristics-of-these-patients
#18
Ulku Aka Akturk, Nagihan Durmus Kocak, Suleyman Akturk, Mert Dumantepe, Aysun Sengul, Mehmet Arif Akcay, Makbule Ozlem Akbay, Feyyaz Kabadayi, Dilek Ernam
OBJECTIVE: To determine the prevalence of abdominal aortic aneurysm (AAA) in patients with chronic obstructive pulmonary disease (COPD) and to assess the characteristics of these patients. MATERIALS AND METHODS: Stable COPD patients (age, >40 years) were included in the study between January 2014 and June 2014. Patients with acute exacerbations and a previous lung resection were excluded. Data regarding demographic characteristics were recorded. The modified Medical Research Council (mMRC) dyspnea scale was used to assess the severity of breathlessness...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28414675/case-report-of-sarcoidosis-as-a-great-mimicker-in-various-populations
#19
C Bowe, F Jenssen, A Espinoza
INTRODUCTION: The prevalence of sarcoidosis varies as much as 1-40 cases per 100,000 depending on region and population. Sarcoid typically occurs in people younger than 50 years old, with a peak incidence with ages between 20 and 40 years old. African Americans are 3 times more likely to develop sarcoidosis than Caucasian Americans, and woman are more likely than men to develop sarcoidosis in any ethnic group; nonetheless, it remains a valid differential across any population. CASE: A 32 year old Hispanic man presented to the Emergency Department with night sweats, fatigue, and 35 pound unintentional weight loss over the last several weeks...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28412094/emotional-problems-quality-of-life-and-symptom-burden-in-patients-with-lung-cancer
#20
Eleshia J Morrison, Paul J Novotny, Jeff A Sloan, Ping Yang, Christi A Patten, Kathryn J Ruddy, Matthew M Clark
OBJECTIVES: Lung cancer is associated with a greater symptom burden than other cancers, yet little is known about the prevalence of emotional problems and how emotional problems may be related to the physical symptom burden and quality of life in newly diagnosed patients with lung cancer. This study aimed to identify the patient and disease characteristics of patients with lung cancer experiencing emotional problems and to examine how emotional problems relate to quality of life and symptom burden...
March 2, 2017: Clinical Lung Cancer
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