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Prevalence lung disease

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https://www.readbyqxmd.com/read/29470706/reduced-proliferation-capacity-of-lung-cells-in-chronic-obstructive-pulmonary-disease
#1
Babett Bartling, Hans-Stefan Hofmann
BACKGROUND AND OBJECTIVES: The prevalence of chronic obstructive pulmonary disease (COPD) and lung emphysema increases with age and both lung diseases are again risk factors for lung cancer. Since a reduced capacity of fibroblasts for proliferation is a good indicator of tissue aging, we studied the cell proliferation of lung fibroblasts from normal and tumor tissue of lung cancer patients depending on lung comorbidities. MATERIAL AND METHODS: Fibroblasts were isolated from tumor and normal lung tissue of 40 lung cancer patients...
February 22, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29466284/an-estimate-of-the-burden-of-fungal-disease-in-norway
#2
Ingvild Nordøy, Liv Hesstvedt, Cecilie Torp Andersen, Haima Mylvaganam, Nicola Isabelle Kols, Birgit Margrethe Falch, Ståle Tofteland, Fredrik Müller, David William Denning
The aim of this study was to examine the burden of fungal disease in Norway, contributing to a worldwide effort to improve awareness of the needs for better diagnosis and treatment of such infections. We used national registers and actual data from the Departments of Microbiology from 2015 and estimated the incidence and/or prevalence of superficial, allergic and invasive fungal disease using published reports on specific populations at risk. One in 6 Norwegians suffered from fungal disease: Superficial skin infections (14...
February 21, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29466074/prevalence-and-survival-impact-of-pretreatment-cancer-associated-weight-loss-a-tool-for-guiding-early-palliative-care
#3
Bhavani S Gannavarapu, Steven K M Lau, Kristen Carter, Nathan A Cannon, Ang Gao, Chul Ahn, Jeffrey J Meyer, David J Sher, Aminah Jatoi, Rodney Infante, Puneeth Iyengar
PURPOSE: Cancer-associated weight loss is associated with poor prognosis in advanced malignancy; however, its pretreatment prevalence and survival impact are inadequately described in large cohorts. Such data, stratified by tumor type and stage, may facilitate the optimal and timely allocation of complementary care, leading to improvements in patient survival and quality of life. METHODS: We performed a retrospective cohort study of 3,180 consecutively treated adult patients with lung or GI (including colorectal, liver, and pancreatic) cancer...
February 21, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29466041/histologic-investigation-of-airway-inflammation-in-postmortem-lung-samples-from-racehorses
#4
Fe Ter Woort, Jeff L Caswell, Luis G Arroyo, Laurent Viel
OBJECTIVE To describe histologic findings in the small airways during postmortem examination of actively racing horses and to quantify the degree of airway inflammation by use of a semiquantitative scoring system. SAMPLE Lung tissues obtained from 95 horses (Thoroughbreds, Standardbreds, and Quarter Horses) that had been actively racing or training. PROCEDURES 10 standardized lung sections were obtained during postmortem examination of 37 horses that had been actively racing or training, and 2 histologic sections of the caudodorsal lung lobes previously collected from each of 58 horses that died or were euthanized during racing or training were also obtained...
March 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29464135/impact-of-cyberknife-radiosurgery-on-median-overall-survival-of-various-parameters-in-patients-with-1-12-brain-metastases
#5
Judith Murovic, Victoria Ding, Summer S Han, John R Adler, Steven D Chang
Introduction This study's objective is to assess various patient, tumor and imaging characteristics and to compare median overall survival (OS) of 150 patients with 1-12 brain metastases post-CyberKnife radiosurgery (CKRS) (Accuray, Sunnyvale, California) alone. Methods Charts of 150 patients, from 2009-2014, treated with only CKRS for brain metastases were reviewed retrospectively for patient, tumor, and imaging characteristics. Parameters included demographics, Eastern Cooperative Oncology Group (ECOG) performance scores, number and control of extracranial disease (ECD) sites, cause of death (COD), histology, tumor volume (TV), and post-CKRS whole brain radiotherapy (WBRT)...
December 8, 2017: Curēus
https://www.readbyqxmd.com/read/29463229/metastatic-cardiac-tumors-from-clinical-presentation-through-diagnosis-to-treatment
#6
Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler
BACKGROUND: To evaluate the prevalence of metastatic tumors involving the myocardium and study their presentation in order to increase awareness to their existence. METHODS: Pathological reports from Sheba Medical Center (Israel, January 1, 2010 through December 31, 2015) and medical records from The Institute for Cardiovascular Diseases of Vojvodina, Sremska Kamenica (Serbia, 23 years period) were screened for cases of metastatic cardiac tumors. Medical, radiological and pathological data of identified cases was retrieved and reviewed...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29462659/safer-approaches-to-therapeutic-modulation-of-tgf-%C3%AE-signaling-for-respiratory-disease
#7
REVIEW
Philippe Lachapelle, Meina Li, Jo Douglass, Alastair Stewart
The transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is established in the most prevalent chronic respiratory diseases including asthma, COPD, lung cancer and idiopathic pulmonary fibrosis. Despite the overwhelming burden of respiratory diseases in the world, new pharmacological therapies have been limited in impact...
February 17, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29460489/exercise-induced-pulmonary-hemorrhage-in-barrel-racing-horses-in-the-pacific-northwest-region-of-the-united-states
#8
Jenifer R Gold, Donald P Knowles, Todd Coffey, Warwick M Bayly
BACKGROUND: Exercise-induced pulmonary hemorrhage (EIPH) refers to bleeding from the lungs in association with strenuous exercise. It has been documented in race horses but little information exists on EIPH in barrel racing horses. HYPOTHESIS/OBJECTIVES: Our goals were to evaluate the presence of EIPH in barrel racing horses and estimate its prevalence in the Pacific Northwest. ANIMALS: 149 barrel racing horses enrolled at events in WA (11), ID (3), and MT (33)...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29458568/nanoformulations-for-targeted-drug-delivery-to-prostate-cancer-an-overview
#9
Soundararajan Hema, Selvarathinam Thambiraj, Dhesingh Ravi Shankaran
Cancer is the second leading causes of death worldwide and it is one of the fatal diseases that kill millions of people every year. It is characterized by uncontrolled proliferation of cells and loss of apoptosis that generates an abnormal mass of cells or tumors. Prostate cancer (PCa) is one of the most common cancers in men and the risk is higher over the age of 55-65. Currently, PCa is the second most common cancer, which causes death in men has a high prevalence with relatively lower cancer mortality risk compared to lung and colon cancer...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29458244/clinical-and-molecular-characteristics-of-pulmonary-sarcomatoid-carcinoma
#10
Jae Kyeom Sim, Sang Mi Chung, Jong Hyun Choi, Jee Youn Oh, Seung Heon Lee, Je Hyeong Kim, Kyung Hoon Min, Gyu Young Hur, Jae Jeong Shim, Kyung Ho Kang, Bong Kyung Shin, Ju Han Lee, Sung Yong Lee
Background/Aims: Pulmonary sarcomatoid carcinoma (PSC) is a poorly differentiated non-small cell lung cancer (NSCLC) that contains components of spindle or giant cells. Owing to its low prevalence, there are insufficient data regarding its clinical features, therapeutic strategies and prognosis. Methods: The medical records of 26 patients diagnosed with PSC from January 2009 to June 2015 were reviewed and analyzed for clinicopathological characteristics, treatment modality, and outcomes...
February 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29453386/anti-fibrotic-effects-of-cxcr4-targeting-i-body-ad-114-in-preclinical-models-of-pulmonary-fibrosis
#11
K Griffiths, D M Habiel, J Jaffar, U Binder, W G Darby, C G Hosking, A Skerra, G P Westall, C M Hogaboam, M Foley
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease that is prevalent in individuals >50 years of age, with a median survival of 3-5 years and limited therapeutic options. The disease is characterized by collagen deposition and remodeling of the lung parenchyma in a process that is thought to be driven by collagen-expressing immune and structural cells. The G-protein coupled C-X-C chemokine receptor 4, CXCR4, is a candidate therapeutic target for IPF owing to its role in the recruitment of CXCR4 + fibrocytes from the bone marrow to fibrotic lung tissue and its increased expression levels by structural cells in fibrotic lung tissue...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452423/anti-citrullinated-alpha-enolase-antibodies-interstitial-lung-disease-and-bone-erosion-in-rheumatoid-arthritis
#12
Alessia Alunno, Onelia Bistoni, Federico Pratesi, Giuliana Maria Concetta La Paglia, Ilaria Puxeddu, Paola Migliorini, Roberto Gerli
Objectives: RA is an articular chronic inflammatory disease that in a subgroup of patients can also present with extra-articular manifestations (EAMs). Despite intense investigation on this topic, reliable biomarkers for EAMs are lacking. In recent years several ACPAs, including those targeting anti-citrullinated alpha enolase peptide-1 (anti-CEP-1), have been identified in patients with RA. Data about the ability of anti-CEP-1 to predict the development of erosive disease are confliciting and no evidence concerning their possible association with EAMs in RA is currently available...
February 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29449898/targeted-therapy-of-brain-metastases-latest-evidence-and-clinical-implications
#13
REVIEW
Rodica Di Lorenzo, Manmeet S Ahluwalia
Brain metastases (BM) occur in 20-40% of patients with cancer and 60-75% of patients with BM become symptomatic. Due to an aging population and advances in the treatment of primary cancers, patients are living longer and are more likely to experience complications from BM. The diagnosis of BM drastically worsens long-term survival rates, with multiple metastases being a poor prognostic factor. Until recently, the mainstay of treatment consisted of stereotactic radiosurgery (SRS), surgical resection, whole brain radiation therapy (WBRT), or a combination of these modalities...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#14
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447395/characteristics-and-outcomes-of-coronavirus-infection-in-children-the-role-of-viral-factors-and-an-immunocompromised-state
#15
Chikara Ogimi, Janet A Englund, Miranda C Bradford, Xuan Qin, Michael Boeckh, Alpana Waghmare
Background: Immunocompromised children might be predisposed to serious infections from human coronaviruses (HCoVs), including strains OC43, NL63, HKU1, and 229E; however, the virologic and clinical features of HCoV infection in immunocompromised children have not been compared to those in nonimmunocompromised children. Methods: We retrospectively analyzed a cohort of children who presented to Seattle Children's Hospital and in whom HCoV was detected by a multiplex respiratory polymerase chain reaction assay of a nasal sample between October 2012 and March 2016...
February 13, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29447330/is-central-lung-tumour-location-really-predictive-for-occult-mediastinal-nodal-disease-in-suspected-non-small-cell-lung-cancer-staged-cn0-on-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#16
Herbert Decaluwé, Johnny Moons, Steffen Fieuws, Walter De Wever, Christophe Deroose, Alessia Stanzi, Lieven Depypere, Kristiaan Nackaerts, Johan Coolen, Maarten Lambrecht, Eric Verbeken, Dirk De Ruysscher, Johan Vansteenkiste, Dirk Van Raemdonck, Paul De Leyn, Christophe Dooms
OBJECTIVES: Current guidelines recommend preoperative invasive mediastinal staging in centrally located tumours with negative mediastinum on positron emission tomography-computed tomography, based on a 20-30% prevalence of occult mediastinal disease (pN2-3). However, a uniform definition of central tumour location is lacking. Our objective was to determine the best definition in predicting occult pN2-3. METHODS: A single-institution database was queried for patients with (suspected) non-small-cell lung cancer staged cN0 after positron emission tomography-computed tomography and referred to invasive staging and/or primary surgery...
February 13, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29446981/diet-pattern-and-respiratory-morbidity-in-the-atherosclerosis-risk-in-communities-study
#17
Emily P Brigham, Lyn M Steffen, Stephanie J London, Danielle Boyce, Gregory B Diette, Nadia N Hansel, Jessica Rice, Meredith C McCormack
RATIONALE: Dietary intake is a potential risk factor for respiratory morbidity in adult populations. Few studies capture the effect of diet patterns, representative of combination of nutrients consumed, on respiratory morbidity in combination with objective measures of lung function. OBJECTIVES: To evaluate patterns of dietary intake in relation to respiratory morbidity and objective measures of lung function in a U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">The Atherosclerosis Risk in Communities (ARIC) Study enrolled 15,792 participants from four U...
February 15, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29444925/increasing-incidence-and-prevalence-of-world-health-organization-groups-1-to-4-pulmonary-hypertension-a-population-based-cohort-study-in-ontario-canada
#18
D Thiwanka Wijeratne, Katherine Lajkosz, Susan B Brogly, M Diane Lougheed, Li Jiang, Ahmad Housin, David Barber, Ana Johnson, Katharine M Doliszny, Stephen L Archer
BACKGROUND: The World Health Organization recognizes 5 groups of pulmonary hypertension (PH), categorized by pathogenesis or comorbidity: 1-pulmonary arterial hypertension 2-left-heart disease, 3-lung disease and hypoxia 4-chronic thromboembolic disease, and 5-miscellaneous. The epidemiology of PH, apart from group 1, is largely unknown. METHODS AND RESULTS: We describe incidence, prevalence, comorbidities, mortality and prescribing patterns for groups 1 to 4 PH from 1993 to 2012...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29444329/gastroesophageal-reflux-symptoms-are-not-sufficient-to-guide-esophageal-function-testing-in-lung-transplant-candidates
#19
S Posner, J Zheng, R K Wood, R A Shimpi, M G Hartwig, S-C Chow, D A Leiman
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testing as part of the wait-listing process but guidelines for testing in this population are lacking. The aim of this study is to describe whether symptoms of gastroesophageal reflux correlate with abnormal results on pH-metry and high-resolution manometry and can be used to identify those who require testing...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444139/post-discharge-body-weight-and-neurodevelopmental-outcomes-among-very-low-birth-weight-infants-in-taiwan-a-nationwide-cohort-study
#20
Chung-Ting Hsu, Chao-Huei Chen, Ming-Chih Lin, Teh-Ming Wang, Ya-Chi Hsu
BACKGROUND: Premature infants are at high risk for developmental delay and cognitive dysfunction. Besides medical conditions, growth restriction is regarded as an important risk factor for cognitive and neurodevelopmental dysfunction throughout childhood and adolescence and even into adulthood. In this study, we analyzed the relationship between post-discharge body weight and psychomotor development using a nationwide dataset. MATERIALS AND METHODS: This was a nationwide cohort study conducted in Taiwan...
2018: PloS One
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