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https://www.readbyqxmd.com/read/29346760/single-cell-transcriptional-profiling-reveals-cellular-diversity-and-intercommunication-in-the-mouse-heart
#1
Daniel A Skelly, Galen T Squiers, Micheal A McLellan, Mohan T Bolisetty, Paul Robson, Nadia A Rosenthal, Alexander R Pinto
Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq)...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346340/disparities-in-preconception-health-indicators-%C3%A2-behavioral-risk-factor-surveillance-system-2013-2015-and-pregnancy-risk-assessment-monitoring-system-2013-2014
#2
Cheryl Robbins, Sheree L Boulet, Isabel Morgan, Denise V D'Angelo, Lauren B Zapata, Brian Morrow, Andrea Sharma, Charlan D Kroelinger
PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive years (defined here as aged 18-44 years). Improvement of both birth outcomes and the woman's health occurs when preconception health is optimized. Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. The National Preconception Health and Health Care Initiative's Surveillance and Research work group suggests ten prioritized indicators that states can use to monitor programs or activities for improving the preconception health status of women of reproductive age...
January 19, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29346062/television-viewing-time-physical-activity-and-mortality-among-african-americans
#3
Tasnim F Imran, Mark Ommerborn, Cheryl Clark, Adolfo Correa, Patricia Dubbert, J Michael Gaziano, Luc Djoussé
BACKGROUND: Prolonged television viewing time, a marker of sedentary activity, is independently associated with increased all-cause mortality; however, this association has rarely been studied in African Americans. The objective of our study was to examine the association between television viewing time and mortality among African Americans by using data from the Jackson Heart Study (JHS). METHODS: We studied 5,289 participants from the JHS study who reported television viewing time (h/day) in the JHS baseline questionnaire from 2000 through 2004...
January 18, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29345596/the-coronary-artery-risk-detection-in-appalachian-communities-cardiac-project-an-18-year-review
#4
Eloise Elliott, Christa Lilly, Emily Murphy, Lee A Pyles, Lesley Cottrell, William A Neal
The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project is a chronic disease risk factor surveillance, intervention, and research initiative aimed at combating the unacceptably high prevalence of heart disease, diabetes, and other chronic illnesses in West Virginia. The initial goal of the CARDIAC Project when it was implemented in elementary schools in West Virginia during the 1998-1999 school year was to identify dyslipidemic children and their parents, and apply novel intervention strategies...
January 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29344402/young-asian-men-with-diabetes-have-the-highest-risk-for-acute-coronary-events-retrospective-cohort-analyses
#5
Ansu Basu, Nithya Sukumar, Robert Ej Ryder
Objective: To understand the ethnic differences in coronary heart disease risk among inpatients with diabetes following acute coronary syndrome. Design: Single-centre retrospective cohort-analysis of patients with type II diabetes over a six-year period receiving standard care. Setting: Birmingham, UK. Participants: One thousand and one hundred and five patients with type II diabetes from a multi-ethnic background. Main outcome measures: Odds ratios of coronary heart disease events among three ethnic groups...
January 2018: JRSM Open
https://www.readbyqxmd.com/read/29341296/the-five-year-survival-of-children-with-down-syndrome-in-norway-1994-2009-differed-by-associated-congenital-heart-defects-and-extracardiac-malformations
#6
Kristoffer Brodwall, Gottfried Greve, Elisabeth Leirgul, Kari Klungsøyr, Henrik Holmstrøm, Stein Emil Vollset, Nina Øyen
AIM: We investigated the prevalence of Down syndrome in a nationwide birth cohort, focusing on congenital heart defects, their associations with extracardiac malformations, and survival. METHODS: National registers were used to identify Norwegian births (1994-2009) and deaths (1994-2014) and updated with hospital diagnoses. We estimated birth defect frequencies in Down syndrome and the general population, the association between heart defects and extracardiac malformations and hazard ratios for death from different combinations of heart defects and extracardiac malformations...
January 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29340121/complications-of-transfusion-dependent-%C3%AE-thalassemia-patients-in-sistan-and-baluchistan-south-east-of-iran
#7
Maryam Yaghobi, Ebrahim Miri-Moghaddam, Naderi Majid, Ali Bazi, Ali Navidian, Asiyeh Kalkali
Background: Thalassemia syndromes are among prevalent hereditary disorders imposing high expenses on health-care system worldwide and in Iran. Organ failure represents a life-threatening challenge in transfusion- dependent β-thalassemia (TDT) patients. The purpose of the present study was to determine the frequency of organ dysfunctions among TDT patients in Sistan and Baluchistan province in South-East of Iran. Materials and Methods: Laboratory and clinical data were extracted from medical records as well as by interviews...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29336633/the-relationship-between-asthma-and-depression-in-a-community-based-sample
#8
Mahima Akula, Alexandra Kulikova, David A Khan, E Sherwood Brown
OBJECTIVE: Asthma is an increasingly prevalent disease that is associated with substantial physical and financial burdens. Additionally, asthma is linked to psychiatric disorders. This study examines the relationship between asthma diagnosis, current depressive symptoms, and lifetime psychiatric disorder history in a large, community-based sample. METHODS: We analyzed data from 2168 participants in the Dallas Heart Study, a large, diverse, community-based sample of people designed to be representative of the Dallas County population...
January 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29336630/ameliorating-role-of-lycopene-tomato-puree-and-spirulina-tomato-puree-on-the-hematology-of-fluoride-exposed-swiss-albino-mice
#9
Shweta Sharma, Puneet Parashar, Subhasini Sharma, Kanta Prasad Sharma
Plant species rich in antioxidants (vitamins, flavonoids, lignans, and carotenoids) have been explored for complementary therapy of chronic diseases (cancers, coronary heart disease) and mitigation of pollutant toxicity. This article investigates their ameliorative role on selective hematological and serum biochemical parameters in fluoride-exposed (190 mg/kg body weight) Swiss albino mice pretreated with the antioxidant-rich diet supplements tomato puree (with and without peels), spirulina (cyanobacteria), and lycopene (present in tomato) for 45 days prior to entry into experimental protocol...
January 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29335891/serum-bilirubin-concentration-is-associated-with-left-ventricular-remodeling-in-patients-with-type-2-diabetes-mellitus-a-cohort-study
#10
Tomoaki Inoue, Noriyuki Sonoda, Shinsuke Hiramatsu, Shinichiro Kimura, Yoshihiro Ogawa, Toyoshi Inoguchi
INTRODUCTION: Previous studies have shown that serum bilirubin concentration is inversely associated with the risk of cardiovascular disease. The relationship between serum bilirubin concentration and left ventricular geometry, however, has not been investigated in patients with diabetes mellitus. METHODS: In this cohort study, 158 asymptomatic patients with type 2 diabetes mellitus without overt heart disease were enrolled. Left ventricular structure and function were assessed using echocardiography...
January 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29334922/relative-contribution-of-various-chronic-diseases-and-multi-morbidity-to-potential-disability-among-dutch-elderly
#11
Riaan Botes, Karin M Vermeulen, Janine Correia, Erik Buskens, Fanny Janssen
BACKGROUND: The amount of time spent living with disease greatly influences elderly people's wellbeing, disability and healthcare costs, but differs by disease, age and sex. METHODS: We assessed how various single and combined diseases differentially affect life years spent living with disease in Dutch elderly men and women (65+) over their remaining life course. Multistate life table calculations were applied to age and sex-specific disease prevalence, incidence and death rates for the Netherlands in 2007...
January 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29332678/relationship-of-sleep-pattern-and-snoring-with-chronic-disease-findings-from-a-nationwide-population-based-survey
#12
Fakir Md Yunus, Safayet Khan, Dipak K Mitra, Sabuj Kanti Mistry, Kaosar Afsana, Mahfuzar Rahman
OBJECTIVES: To investigate the association of total sleep time and presence or absence of snoring with chronic disease among the Bangladeshi adult population. DESIGN: Cross-sectional survey. SETTING: Urban and rural Bangladesh. PARTICIPANTS: A total of 12,338 men and women aged ≥35 years. MEASUREMENTS: Total sleep time was considered as the total hours of sleep in 24 hours. Furthermore, sleep time was categorized into <7, 7-9, and >9 hours according to National Sleep Foundation (2015) guidelines...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29332673/prevalence-and-comorbidity-of-sleep-conditions-in-australian-adults-2016-sleep-health-foundation-national-survey
#13
Sarah L Appleton, Tiffany K Gill, Carol J Lang, Anne W Taylor, R Douglas McEvoy, Nigel P Stocks, David A González-Chica, Robert J Adams
OBJECTIVE: To determine the prevalence of sleep conditions (obstructive sleep apnea [OSA], insomnia symptoms, simple snoring, and restless legs) and their associated burden of chronic conditions in a community sample. DESIGN: Cross-sectional national adult online survey. SETTING: Community-based sample. PARTICIPANTS: Australian adults ≥18 years, N = 1011. MEASUREMENTS: A cross-sectional national online survey assessed diagnosed OSA, OSA symptoms, insomnia symptoms, sleep problems, excessive daytime sleepiness (Epworth Sleepiness Scale ≥11), and physician-diagnosed health conditions (heart disease, diabetes, hypertension, reflux disease, lung disease, depression, anxiety/panic disorder, arthritis)...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29331539/serum-vitamin-d-deficiency-and-risk-of-hospitalization-for-heart-failure-prospective-results-from-the-moli-sani-study
#14
S Costanzo, A De Curtis, A Di Castelnuovo, M Persichillo, M Bonaccio, G Pounis, C Cerletti, M B Donati, G de Gaetano, L Iacoviello
BACKGROUND AND AIMS: Evidence indicates that Vitamin D deficiency may be associated with increased risk of cardiovascular disease, although findings on risk of heart failure (HF) are controversial. We investigated the relationship between serum Vitamin D and the incidence of hospitalization for HF in a large prospective cohort of Italian adults. METHODS AND RESULTS: 19,092 (49% men, age range 35-99 years) HF-free individuals from the Moli-sani study, with complete data on serum Vitamin D (25-hydroxyvitamin) levels and incident hospitalized HF, were analysed...
December 7, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29331057/manifestations-and-mechanisms-of-myocardial-lipotoxicity-in-obesity
#15
Arthur C Sletten, Linda R Peterson, Jean E Schaffer
Environmental and socioeconomic changes over the past thirty years have contributed to a dramatic rise in the worldwide prevalence of obesity. Heart disease is among the most serious health risks of obesity, with increases in both atherosclerotic coronary heart disease and heart failure among obese individuals. In this review, we focus on primary myocardial alterations in obesity that include hypertrophic remodeling and diastolic dysfunction. Obesity-associated perturbations in myocardial and systemic lipid metabolism are important contributors to cardiovascular complications of obesity...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29330351/the-vegfa165b-isoform-is-dysregulated-in-senescent-endothelial-cells-and-may-be-associated-with-prevalent-and-incident-coronary-heart-disease
#16
Eva Latorre, Luke C Pilling, Benjamin P Lee, Stefania Bandinelli, David Melzer, Luigi Ferrucci, Lorna W Harries
Coronary heart disease (CHD) is a leading cause of morbidity in the over 65s; over 40% of all deaths are due to this condition. The association between increasing age and CHD is well-documented; the accumulation of senescent cells in cardiac and vascular tissues may represent one factor underpinning this observation. We aimed to identify senescence-related expression changes in primary human senescent cardiomyocytes and endothelial cells and to relate transcript expression in peripheral blood leucocytes to prevalent and incident CHD in the InCHIANTI study of aging...
January 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29330257/hemoglobin-albuminuria-and-kidney-function-in-cardiovascular-risk-the-aric-atherosclerosis-risk-in-communities-study
#17
Junichi Ishigami, Morgan E Grams, Rakhi P Naik, Melissa C Caughey, Laura R Loehr, Shinichi Uchida, Josef Coresh, Kunihiro Matsushita
BACKGROUND: Reduced estimated glomerular filtration rate (eGFR) and elevated urinary albumin-to-creatinine ratio (ACR) individually increase risk of cardiovascular disease (CVD). We hypothesized that these associations are stronger among people with abnormal (both low and high) hemoglobin levels. METHODS AND RESULTS: Using 5801 participants with available hemoglobin measures of the ARIC (Atherosclerosis Risk in Community) study in 1996-1998, we explored the cross-sectional association of eGFR and ACR with hemoglobin levels and their longitudinal associations with CVD (heart failure, coronary heart disease, and stroke) risk through 2013...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29329947/-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#18
REVIEW
C Schweitzer
Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material...
January 9, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29327942/efficient-selective-screening-for-heart-failure-in-elderly-men-and-women-from-the-community-a-diagnostic-individual-participant-data-meta-analysis
#19
Rogier F Kievit, Aisha Gohar, Arno W Hoes, Michiel L Bots, Evelien Es van Riet, Yvonne van Mourik, Loes Cm Bertens, Leandra Jm Boonman-de Winter, Hester M den Ruijter, Frans H Rutten
Background Prevalence of undetected heart failure in older individuals is high in the community, with patients being at increased risk of morbidity and mortality due to the chronic and progressive nature of this complex syndrome. An essential, yet currently unavailable, strategy to pre-select candidates eligible for echocardiography to confirm or exclude heart failure would identify patients earlier, enable targeted interventions and prevent disease progression. The aim of this study was therefore to develop and validate such a model that can be implemented clinically...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29327518/a-study-of-cardiovascular-abnormalities-in-hiv-positive-patients-in-a-tertiary-care-hospital-in-northern-india
#20
Shyam Chaudhary, Apurva, Kamal Kumar Sawlani, D Himanshu Reddy, Sharad Chandra Yadav, Munna Lal Patel, Anil Kumar Tripathi, Arvind Kumar Vaish
Introduction: Cardiovascular illness is common in patients with HIV infection, particularly in the later course of disease. Cardiovascular abnormalities in people living with HIV disease (PLHIV) often go unrecognized or untreated resulting in increased cardiovascular related morbidity and mortality and reduced quality of life. The prevalence of cardiac involvement in PLHIV has been reported to range between 28 to 73%. However, the incidence of symptomatic heart failure in HIV positive patients is 8-10%...
December 2017: Journal of the Association of Physicians of India
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