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Preeclampsia eclampsia

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https://www.readbyqxmd.com/read/29348884/alpha-1-antitrypsin-functions-as-a-protective-factor-in-preeclampsia-through-activating-smad2-and-inhibitor-of-dna-binding-4
#1
Yaling Feng, Nan Wang, Jianjuan Xu, Jinfang Zou, Xi Liang, Huan Liu, Ying Chen
Pre-eclampsia (PE) is one of the most common reason for high morbidity and mortality of maternal and prenatal infants. Production from oxidative stress results in maternal ROS system and anti-oxidation defense system imbalance to promote tissue ischemia and hypoxia, and ultimately impairs the maternal organs and placenta. Our previous study showed that exogenous Alpha-1-antitrypsin (AAT) and overexpression of AAT in umbilical vein cell (HUVEC) hypoxia-reoxygenation model could increase the activity of antioxidant enzymes, and played a protective role in preeclampsia animal model...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29347927/prevalence-of-hypertensive-disorders-of-pregnancy-in-ethiopia-a-systemic-review-and-meta-analysis
#2
Abadi Kidanemariam Berhe, Getachew Mullu Kassa, Gedefaw Abeje Fekadu, Achenef Asmamaw Muche
BACKGROUND: Although hypertensive disorders of pregnancy are the leading cause of poor perinatal outcomes in Ethiopia, there is no study that shows the national prevalence. Therefore, the aim of this study was to estimate the national pooled prevalence of hypertensive disorders of pregnancy from studies conducted in different parts of the country. METHODS: Databases; MEDLINE, PubMed, HINARI, EMBASE, Google Scholar and African Journals Online were searched by using different search terms on HDP and Ethiopia...
January 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29340329/a-salivary-urea-nitrogen-dipstick-to-detect%C3%A2-obstetric-related-acute-kidney-disease-in-malawi
#3
Rhys D R Evans, William Cooke, Ulla Hemmila, Viviane Calice-Silva, Jochen Raimann, Alison Craik, Chimwemwe Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer, Nathan W Levin, Roberto Pecoits-Filho
Introduction: Obstetric-related acute kidney injury (AKI) is associated with adverse outcomes for mother and fetus, particularly in low-income countries. However, laboratory-independent tools to facilitate diagnosis are lacking. We assessed the diagnostic performance of a salivary urea nitrogen (SUN) dipstick to detect obstetric-related acute kidney disease in Malawi. Methods: Women at high risk for AKI admitted to an obstetric unit in Blantyre, Malawi, were recruited between 21 September and 11 December 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29331477/atypical-presentation-of-pregnancy-related-hemolytic-uremic-syndrome
#4
Salim Baghli, Catherine Abendroth, Umar Farooq, Jennifer A Schaub
The cause of acute kidney injury during pregnancy and in the postpartum period can be particularly challenging to diagnose, especially when it is necessary to differentiate among preeclampsia; eclampsia; hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome; and thrombotic microangiopathies (TMAs). All these disease entities can present with kidney failure, microangiopathic hemolytic anemia, and thrombocytopenia. We present a teaching case of atypical hemolytic uremic syndrome in the postpartum period in a young woman who was found to have mutations of uncertain clinical significance in the complement cascade, including in C3, CFH, and CFI...
January 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29322709/study-of-association-of-thyroid-hormone-in-pre-eclampsia-and-normal-pregnancy
#5
L Harshvardhan, S S Dariya, Aradhana Sharma, Lalita Verma
Aim: The aim of the study was to assess association of thyroid hormone in preeclampsia and normal pregnancy. Material and Method: This was a hospital based observational case control study. Total 100 women were included, out of them 50 normal pregnant women in control group and 50 pre-eclamptic women in case group were included. Result: In this study no significant difference was found in FT3 (p value 0.085) and FT4 (p value 0.065) in control and case group...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313572/cardio-metabolic-risk-profile-in-women-with-previous-history-of-pre-eclampsia
#6
Jalees Fatma, Ritu Karoli, Zeba Siddiqui, H P Gupta, Ashok Chandra, Mahima Pandey
Introduction: Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality. However there is growing evidence that there are differences during the post partum period between subjects with prior preeclampsia and prior uncomplicated pregnancy and women with a history of preeclampsia are more likely to develop cardiovascular disease later in life. The aim of our study was to assess the cardio- metabolic risk profile in women with previous history of pre-eclampsia and to their counterparts who had normal pregnancy...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29302904/acute-kidney-injury-in-pregnancy-with-special-reference-to-pregnancy-specific-disorders-a-hospital-based-study-2014-2016
#7
Jai Prakash, Vivek C Ganiger, Suraj Prakash, Mohammad Iqbal, Deba Prasad Kar, Usha Singh, Ashish Verma
INTRODUCTION: There are numerous reports in the literature describing acute kidney injury in pregnancy (P-AKI) due to various obstetric complications. However, there is a dearth of studies on AKI related to pregnancy-specific disorders from India. We aimed to analyze clinical features and outcome of P-AKI related to pregnancy-specific disorders compared to total pregnancy, in India. METHOD: All pregnant women attending the department of Obstetrics and Gynecology from November 2014 to July 2016 were screened for AKI based on: (1) sudden elevation of serum creatinine ≥ 1 mg/dl; (2) oligoanuria for > 12 h; and (3) need for dialysis...
January 4, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29301419/antenatal-magnesium-sulfate-is-beneficial-or-harmful-in-very-preterm-and-extremely-preterm-neonates-a-new-insight
#8
Bhawan Garg
Magnesium sulfate (MgSO4) is drug of choice for both prevention of eclampsia in women with severe preeclampsia and treatment of eclampsia. Antenatal MgSO4 is now emerging as popular neuroprotective agent in preterm neonates. However, recent studies reported an association of antenatal MgSO4 with feed intolerance, necrotizing enterocolitis and spontaneous intestinal perforation in extremely preterm neonates. In this review article, we discuss both aspects of antenatal MgSO4 in preterm neonates.
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29284338/catastrophic-antiphospholipid-syndrome-and-pregnancy-clinical-report
#9
J Khizroeva, V Bitsadze, A Makatsariya
We have observed the development of a catastrophic antiphospholipid syndrome (CAPS) in a pregnant woman hospitalized at 28 weeks of gestation with a severe preeclampsia. On the same day, an eclampsia attack developed, and an emergency surgical delivery was performed. On the third day, multiorgan failure developed. Examination showed a persistent circulation of lupus anticoagulant, high level of antibodies to cardiolipin, b2-glycoprotein I, and prothrombin. The usual diagnosis of the severe preeclampsia masked a catastrophic antiphospholipid syndrome, exacerbated by the coincident presence of several types of antiphospholipid antibodies...
December 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29273044/a-randomized-controlled-trial-of-exercise-during-pregnancy-on-maternal-and-neonatal-outcomes-results-from-the-pamela-study
#10
Shana Ginar da Silva, Pedro Curi Hallal, Marlos Rodrigues Domingues, Andréa Dâmaso Bertoldi, Mariângela Freitas da Silveira, Diego Bassani, Inácio Crochemore Mohnsam da Silva, Bruna Gonçalves Cordeiro da Silva, Carolina de Vargas Nunes Coll, Kelly Evenson
BACKGROUND: Women are encouraged to be physically active during pregnancy. Despite available evidence supporting antenatal physical activity to bring health benefits for both the mother and child, the most effective way to prevent some maternal and fetal outcomes is still unclear. The purpose of this study was to evaluate the efficacy of an exercise intervention to prevent negative maternal and newborn health outcomes. METHODS: A randomized controlled trial (RCT) nested into the 2015 Pelotas (Brazil) Birth Cohort Study was carried-out with 639 healthy pregnant women, 213 in the intervention group (IG) and 426 in the control (CG) group...
December 22, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29237307/oligohydramnios-is-an-independent-risk-factor-for-perinatal-morbidity-among-women-with-preeclampsia-who-delivered-preterm
#11
Alex Rabinovich, Keren Holtzman, Ilana Shoham-Vardi, Moshe Mazor, Offer Erez
PURPOSE: Determine the relationship between oligohydramnios and adverse maternal and neonatal outcomes in a unique cohort of preterm preeclamptic patients. MATERIALS AND METHODS: A retrospective matched case control study comparing 81 preterm parturients (28 0/7 and 36 6/7 weeks) with preeclampsia and oligohydramnios to 81 preterm preeclamptic patients with a normal amniotic fluid index (AFI). RESULTS: 4.8 percent of all our preterm preeclamptic patients had oligohydramnios...
December 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29197014/eg-vegf-maintenance-over-early-gestation-to-develop-a-pregnancy-induced-hypertensive-animal-model
#12
Déborah Reynaud, Frédéric Sergent, Roland Abi Nahed, Sophie Brouillet, Mohamed Benharouga, Nadia Alfaidy
During the last decade, multiple animal models have been developed to mimic hallmarks of pregnancy-induced hypertension (PIH) diseases, which include gestational hypertension, preeclampsia (PE), or eclampsia. Converging in vitro, ex vivo, and clinical studies from our group strongly suggested the potential involvement of the new angiogenic factor EG-VEGF (endocrine gland-derived-VEGF) in the development of PIH. Here, we described the protocol that served to demonstrate that maintenance of EG-VEGF production over 11...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29187935/-haemorrhagic-stroke-of-the-brainstem-secondary-to-postpartum-eclampsia-about-a-case-and-literature-review
#13
REVIEW
Khadija Ennaqui, Assia Makayssi, Houssine Boufettal, Naima Samouh
Strokes are rare but severe accidents during pregnancy and post-partum period. They are responsible for high mortality and morbidity rates. Pre-eclampsia, eclampsia, and strokes are significantly related. Endothelial dysfunction, alteration of brain self-regulation and severe hypertension are, probably, the cause of many strokes in pregnant women and during postpartum period. We report a case of hemorrhagic stroke of the brainstem in a nonmonitored 21-year old patient at 38 weeks pregnant admitted with severe preeclampsia complicated by eclampsia and then by haemorrhagic stroke of the brainstem on the second post-operative day after cesarean section performed due to suspicion of retroplacental haematoma arisen since her admission...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29174227/angiogenic-and-antiangiogenic-factors-in-preeclampsia
#14
REVIEW
Fernanda Rodrigues Helmo, Angela Maria Moed Lopes, Anna Cecília Dias Maciel Carneiro, Carolina Guissoni Campos, Polyana Barbosa Silva, Maria Luíza Gonçalves Dos Reis Monteiro, Laura Penna Rocha, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
BACKGROUND: Pre-eclampsia is a multifactorial hypertensive disorder that is triggered by placental insufficiency and that accounts for up to 15% of maternal deaths. In normal pregnancies, this process depends on the balance between the expression of angiogenic factors and antiangiogenic factors, which are responsible for remodeling the spiral arteries, as well as for neoangiogenesis and fetal development. PURPOSE: The aim of this review is to discuss the main scientific findings regarding the role of angiogenic and antiangiogenic factors in the etiopathogenesis of preeclampsia...
October 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29172779/the-effect-of-magnesium-sulfate-on-gene-expression-in-maternal-microvascular-endothelial-cells
#15
Dennis K Lee, Anindita Sengupta, Ori Nevo
Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Primary cells from normal pregnancies treated with 80 mg/L magnesium sulfate for 6 h revealed an overall trend of increased expression of angiogenic and vasopressor-related factors by qPCR analyses...
November 27, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29153692/effects-of-postpartum-uterine-curettage-in-the-recovery-from-preeclampsia-eclampsia-a-randomized-controlled-trial
#16
Gamaliel Mc Lean, Osvaldo Reyes, Rodrigo Velarde
OBJECTIVE: To evaluate if postpartum uterine curettage improved the clinical and laboratory parameters in patients with preeclampsia or eclampsia. METHODS: A total of 442 patients with preeclampsia/eclampsia were randomized to postpartum curettage (223) or no procedure (219). Systolic and diastolic blood pressure were recorded and analyzed at hours 6, 12, 24 and 48. Also, several laboratory values and diuresis were evaluated. RESULTS: No statistical differences were found between groups (curettage vs...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29151361/magnesium-sulfate-and-ophthalmic-artery-doppler-velocimetry-in-patients-with-severe-preeclampsia-a-case-series
#17
Cristiane Alves Oliveira, Renato Augusto Moreira de Sa, Karina Vieira Zamprogno, Fabio Gutierrez da Matta, Flávia do Vale Araújo
BACKGROUND: In the present study, we used Doppler velocimetry in the ophthalmic artery to evaluate the hemodynamic status of the intracranial vasculature. This is the first time in the literature that indices of ophthalmic artery Doppler sonography of women with preeclampsia were evaluated before and after the use of magnesium sulfate to prevent eclampsia. CASE PRESENTATION: Indices of ophthalmic artery Doppler sonography of six women with severe preeclampsia at 27 to 33 weeks of gestational age were evaluated before and after the use of magnesium sulfate (10 minutes, 30 minutes, and 60 minutes after the magnesium sulfate loading dosage...
November 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29143991/genetic-and-non-genetic-risk-factors-for-pre-eclampsia-an-umbrella-review-of-systematic-reviews-and-meta-analyses-of-observational-studies
#18
REVIEW
Konstantinos Giannakou, Evangelos Evangelou, Stefania I Papatheodorou
OBJECTIVE: To summarize evidence from the literature on the risk factors associated with preeclampsia, assess the presence of statistical biases and identify associations with robust evidence. METHODS: We searched PubMed and ISI Web of Science from inception to October, 2016, to identify systematic reviews and meta-analyses of observational studies examining associations between genetic and non-genetic risk factors for preeclampsia. For each meta-analysis we estimated the summary effect size by random-effects and fixed-effects models, the 95% confidence interval and the 95% prediction interval...
November 16, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29139276/preventing-stroke-and-assessing-risk-in-women
#19
Tracey Keteepe-Arachi, Sanjay Sharma
Ischaemic stroke is rare in premenopausal women but risk increases with advancing age and doubles in the ten years following the menopause. Up to the age of 75 years men have a 25% higher risk of suffering a stroke compared with women. However, the increased life expectancy of women ultimately results in a higher overall incidence. Twice as many women die from stroke compare with breast cancer. Women with cerebrovascular disease are more likely to present with atypical symptoms than men. Altered mental status (including unresponsiveness, confusion and behavioural change) is the most common nonconventional symptom, and is reported by 23% of women compared with 15% of men...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29132221/2009-iom-guidelines-for-gestational-weight-gain-how-well-do-they-predict-outcomes-across-ethnic-groups
#20
Amal R Khanolkar, Gillian E Hanley, Ilona Koupil, Patricia A Janssen
OBJECTIVE: To determine whether the Institute Of Medicine's (IOM) 2009 guidelines for weight-gain during pregnancy are predictive of maternal and infant outcomes in ethnic minority populations. METHODS: We designed a population-based study using administrative data on 181,948 women who delivered live singleton births in Washington State between 2006-2008. We examined risks of gestational hypertension, preeclampsia/eclampsia, cesarean delivery, and extended hospital stay in White, Black, Native-American, East-Asian, Hispanic, South-Asian and Hawaiian/Pacific islander women according to whether they gained more or less weight during pregnancy than recommended by IOM guidelines...
November 13, 2017: Ethnicity & Health
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