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https://www.readbyqxmd.com/read/29036660/mcnpx-calculations-of-specific-absorbed-fractions-in-some-organs-of-the-human-body-due-to-application-of-133xe-99mtc-and-81mkr-radionuclides
#1
Z Jovanovic, D Krstic, D Nikezic, J M Gomez Ros, P Ferrari
Monte Carlo simulations were performed to evaluate treatment doses with wide spread used radionuclides 133Xe, 99mTc and 81mKr. These different radionuclides are used in perfusion or ventilation examinations in nuclear medicine and as indicators for cardiovascular and pulmonary diseases. The objective of this work was to estimate the specific absorbed fractions in surrounding organs and tissues, when these radionuclides are incorporated in the lungs. For this purpose a voxel thorax model has been developed and compared with the ORNL phantom...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29035353/liquid-metal-organic-frameworks
#2
Romain Gaillac, Pluton Pullumbi, Kevin A Beyer, Karena W Chapman, David A Keen, Thomas D Bennett, François-Xavier Coudert
Metal-organic frameworks (MOFs) are a family of chemically diverse materials, with applications in a wide range of fields, covering engineering, physics, chemistry, biology and medicine. Until recently, research has focused almost entirely on crystalline structures, yet now a clear trend is emerging, shifting the emphasis onto disordered states, including 'defective by design' crystals, as well as amorphous phases such as glasses and gels. Here we introduce a strongly associated MOF liquid, obtained by melting a zeolitic imidazolate framework...
October 9, 2017: Nature Materials
https://www.readbyqxmd.com/read/29034197/characterization-of-calcined-jade-and-its-immunomodulatory-effect-on-macrophage-isolated-from-swiss-albino-mice
#3
Asif Elahi, Deeba S Jairajpuri, Farah Khan
Calcined Jade (CJ) is a metasilicate frequently used in traditional system of medicine as tonic to vital organs with several other pharmacological activities. X-ray powder diffraction (XRPD), inductively coupled plasma mass spectrometry (ICP-MS), atomic absorption spectroscopy (AAS) and CHNS analyzer techniques were used to characterize CJ sample. CJ was administered orally to Swiss albino mice at a dose of 50, 75, 100 and 200 μg/kg body weight for 10 days and modulation of the macrophage mediated innate immune responses was studied...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033394/diagnostic-biomarkers-for-lung-cancer-prevention
#4
Roberto Gasparri, Rosalia Romano, Giulia Sedda, Alessandro Borri, Francesco Petrella, Domenico Galetta, Monica Casiraghi, Lorenzo Spaggiari
Lung cancer is the leading cause of death for neoplasm. The lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offers early detection but are invasive and expensive. Up to date these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodeled and it has been defined as a disease that has its own genetic, biological and metabolic identity and on this new awareness we should base the new screening methods...
October 16, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29032417/clinical-evaluation-for-sublingual-immunotherapy-with-dermatophagoides-farinae-drops-in-adult-patients-with-allergic-asthma
#5
C Zhong, W Yang, Y Li, L Zou, Z Deng, M Liu, X Huang
PURPOSE: The efficacy and safety of sublingual immunotherapy (SLIT) in house dust mite-induced allergic asthma (AA) have yet to be firmly established, especially in adult patients. Our objective is to evaluate the efficacy of SLIT with Dermatophagoides farinae drops in adult patients with AA. METHODS: One hundred and thirty-four adult patient data with house dust mite (HDM)-induced AA who had been treated for 2 years were collected. These patient data that we collected were divided into the SLIT group (n = 85) and control group (n = 49)...
October 14, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29026646/binary-titanium-alloys-as-dental-implant-materials-a-review
#6
REVIEW
Xiaotian Liu, Shuyang Chen, James K H Tsoi, Jukka Pekka Matinlinna
Titanium (Ti) has been used for long in dentistry and medicine for implant purpose. During the years, not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were used. The aim of this review is to describe and compare the current literature on binary Ti alloys, including Ti-Zr, Ti-In, Ti-Ag, Ti-Cu, Ti-Au, Ti-Pd, Ti-Nb, Ti-Mn, Ti-Mo, Ti-Cr, Ti-Co, Ti-Sn, Ti-Ge and Ti-Ga, in particular to mechanical, chemical and biological parameters related to implant application. Literature was searched using the PubMed and Web of Science databases, as well as google without limiting the year, but with principle key terms such as ' Ti alloy', 'binary Ti ', 'Ti-X' (with X is the alloy element), 'dental implant' and 'medical implant'...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29025642/engineered-chimeric-peptides-with-antimicrobial-and-titanium-binding-functions-to-inhibit-biofilm-formation-on-ti-implants
#7
Hongjuan Geng, Yang Yuan, Aidina Adayi, Xu Zhang, Xin Song, Lei Gong, Xi Zhang, Ping Gao
Titanium (Ti) implants have been commonly used in oral medicine. However, despite their widespread clinical application, these implants are susceptible to failure induced by microbial infection due to bacterial biofilm formation. Immobilization of chimeric peptides with antibacterial properties on the Ti surface may be a promising antimicrobial approach to inhibit biofilm formation. Here, chimeric peptides were designed by connecting three sequences (hBD-3-1/2/3) derived from human β-defensin-3 (hBD-3) with Ti-binding peptide-l (TBP-l: RKLPDAGPMHTW) via a triple glycine (G) linker to modify Ti surfaces...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29021211/pfmg1-promotes-osteoblast-differentiation-and-prevents-osteoporotic-bone-loss
#8
Liyuan Li, Pan Wang, Kaiqiang Hu, Xiaoyan Wang, Wenping Cai, Chao Ai, Shangfeng Liu, Zhao Wang
Nacre is a widely used mineral medicine that has been reported to have beneficial effects in bone remodeling without an increase in inflammation. Water-soluble nacre matrix has been demonstrated to be responsible for the effect, yet core active ingredients are unknown. Pinctada fucata mantle gene 1 (PFMG1) was first discovered in the mantle tissue of Pinctada fucata. The protein has 2 EF-hands, a calcium-binding domain. PFMG1 protein can affect the growth of calcium carbonate crystals in vitro Here, we demonstrate that PFMG1 affects cell-cycle distribution and promotes preosteoblast proliferation...
October 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28993159/prevention-of-cholesterol-gallstone-disease-by-schaftoside-in-lithogenic-diet-induced-c57bl-6-mouse-model
#9
Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou, Suiqing Mi
Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. Whether SS inhibits cholesterol (Ch) gallstone formation has not been investigated. This study examined the effects of oral intake of SS on Ch gallstone formation in C57BL/6 mice fed a lithogenic diet. The rate of gallstone formation was recorded. Levels of Ch, triglycerides (TG) and bile salts (BS) were measured in the bile and serum...
October 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28992620/potential-ameliorative-effects-of-qing-ye-dan-against-cadmium-induced-prostatic-deficits-via-regulating-nrf-2-ho-1-and-tgf-%C3%AE-1-smad-pathways
#10
Lifen Du, Yongfang Lei, Jinglou Chen, Hongping Song, Xinying Wu
BACKGROUND/AIMS: Cadmium (Cd) is an environmental pollutant with reproductive toxicity. Swertia mileensis is used in Chinese medicine for the treatment of prostatic deficits and named as Qing Ye Dan (QYD). This study was undertaken to investigate the potential protective effects of QYD against Cd-induced prostatic deficits. METHOD: Rat model of prostatic deficits was induced by 0.2 mg/kg/d CdCl2 subcutaneous injection for 15 days. The prostatic oxidative stress was evaluated by detecting the levels of malondialdehyde, nitric oxide, reduced/ oxidized glutathione, total sulfhydryl groups and enzymatic antioxidant status...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28990637/qualitative-study-of-depression-literacy-among-korean-american-parents-of-adolescents
#11
Yoo Mi Jeong, Linda L McCreary, Tonda L Hughes
Lack of depression literacy is associated with low help-seeking behaviors for mental health care in adolescents. As parents generally determine adolescents' health care, ensuring parents can recognize depressive symptoms is crucial. The current study explored depression literacy among Korean American parents of adolescents ages 12 to 19 using a qualitative descriptive design. Semantic content analysis was performed using data from three focus group interviews conducted in 2015 with Korean American parents (10 mothers, four fathers) of adolescents...
October 6, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28990045/anti%C3%A2-tumor-effects-of-bakuchiol-on-human-gastric-carcinoma-cell-lines-are-mediated-through-pi3k-akt-and-mapk-signaling-pathways
#12
Long Lv, Bo Liu
Bakuchiol is extracted from Psoralea corylifolia, a member of the Leguminosae family, has been used in Indian Ayurvedic and Chinese traditional medicine, and it possesses an anticancer effect. The primary aim of the present study was to identify the molecular mechanisms underlying the anticancer effect of bakuchiol monoterpenes. Bakuchiol treatment significantly inhibited NUGC3 human gastric cancer cell viability in a concentration dependent manner. In addition, bakuchiol significantly increased the apoptotic cell population in the sub‑G1 phase, and Annexin‑V‑fluorescein isothiocyanate/propidium iodide double staining confirmed the increase in apoptosis...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986937/effects-of-chinese-herbal-medicine-and-cold-exposure-on-plasma-glucose-leucine-and-energy-metabolism-in-sheep
#13
X Liang, J Jin, X Bi, M Kamruzzaman, T Kudo, H Sano
An experiment was carried out to assess the feeding effect of Chinese herbal medicine on N balance, ruminal fermentation characteristics, kinetics of plasma glucose, leucine and energy metabolism in sheep kept at thermoneutral environment (23°C) or exposed to cold (2-4°C). Four sheep were subjected to either mixed hay (MH-diet) or hay supplemented with 2% of a traditional nourishing Chinese herbal medicine mixture (Astragalus root, Angelica root and Atractylodes rhizome; CHM-diet) over two 23-day periods using a crossover design...
October 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28984816/reproducibility-of-differential-renal-function-measurement-using-technetium-99m-ethylenedicysteine-dynamic-renal-scintigraphy-a-french-prospective-multicentre-study
#14
Duc L Nguyen, Claire de Labriolle-Vaylet, Emmanuel Durand, Philippe X Fernandez, François Bonnin, Daniel Deliu, Florent L Besson, Philippe Chaumet-Riffaud
OBJECTIVE: Dynamic renal scintigraphy remains the gold standard for assessing differential renal function (DRF). Recently, technetium-99m-ethylenedicysteine (Tc-EC) was shown to be valuable and had similar quality images as technetium-99m-mercaptoacetyltriglycine (Tc-MAG3). However, its reproducibility has never been confirmed. The aim of this study was to perform the first evaluation of Tc-EC reproducibility for assessing DRF in children who were referred for hydronephrosis or urinary tract dilatation...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28984729/simulation-based-education-enhances-patient-safety-behaviors-during-central-venous-catheter-placement
#15
Tonya Jagneaux, Terrell S Caffery, Mandi Wilkes Musso, Ann C Long, Lauren Zatarain, Erik Stopa, Nathan Freeman, Cara Cantelli Quin, Glenn N Jones
OBJECTIVE: We describe the effect of simulation-based education on residents' adherence to protocols for and performance of central venous access. METHODS: Internal medicine and emergency medicine residents underwent a central venous access course that included a lecture, video presentation, readings, and simulation demonstrations presented by faculty. Baseline data were collected before the course was initiated. After a skills session where they rehearsed their ultrasound-guided central venous access skills, residents were evaluated using a procedural checklist and written knowledge exam...
October 4, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28982542/a-molecular-mechanism-on-the-antiapoptotic-effects-of-zingerone-in-isoproterenol-induced-myocardial-infarcted-rats
#16
Ponnian Stanely Mainzen Prince, Kunchupillai Lakhsmanan Hemalatha
Myocardial infarction continues to be a major public health problem, not only in western countries but also increasingly in developing countries and makes significant contribution to the mortality statistics. Reduction in mortality and prevention of myocardial infarction are of utmost importance. Recently, there has been an increased interest globally to identify natural compounds that are pharmacologically potent and have low or no adverse effects for use in preventive medicine. Oxidative stress and cardiomyocyte apoptosis play a significant role in the progression of myocardial infarction...
October 2, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28981269/estimating-electron-density-support-for-individual-atoms-and-molecular-fragments-in-x-ray-structures
#17
Agnes Meyder, Eva Nittinger, Gudrun Lange, Robert Klein, Matthias Rarey
Macromolecular structures resolved by X-ray crystallography are essential for life science research. While some methods exist to automatically quantify the quality of the electron density fit, none of them is without flaws. Especially the question of how well individual parts like atoms, small fragments, or molecules are supported by electron density is difficult to quantify. While taking experimental uncertainties correctly into account, they do not offer an answer on how reliable an individual atom position is...
October 5, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28980934/regulation-of-signaling-pathways-by-tanshinones-in-different-cancers
#18
X Lin, M Z Qureshi, M A Romero, S Khalid, A Aras, U Ozbey, A A Farooqi
Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28980137/lifestyle-medicine-and-the-management-of-cardiovascular-disease
#19
REVIEW
Kimberly N Doughty, Nelson X Del Pilar, Amanda Audette, David L Katz
PURPOSE OF REVIEW: Evidence has clearly demonstrated the importance of lifestyle factors (e.g., diet, physical activity, smoking) in the development of cardiovascular disease (CVD). Interventions targeting these behaviors may improve outcomes for CVD patients. The aim of this review is to summarize the effects of lifestyle interventions in individuals with established CVD. RECENT FINDINGS: Most recent trials focused on diet, physical activity, stress reduction, or a combination of these...
October 4, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28979076/development-and-optimization-of-dispersible-tablet-of-bacopa-monnieri-with-improved-functionality-for-memory-enhancement
#20
Vaishali Tejas Thakkar, Amol Deshmukh, Lal Hingorani, Payal Juneja, Lalji Baldaniya, Asha Patel, Tosha Pandya, Mukesh Gohel
INTRODUCTION: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. OBJECTIVE: Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets. MATERIALS AND METHODS: The inclusion complex of Bacopa monnieri and β-cyclodextrin was prepared in different molar ratios of Bacopa monnieri by Co-precipitation method...
July 2017: Journal of Pharmacy & Bioallied Sciences
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