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https://www.readbyqxmd.com/read/28523560/stem-cell-technology-for-epi-genetic-brain-disorders
#1
Renzo J M Riemens, Edilene S Soares, Manel Esteller, Raul Delgado-Morales
Despite the enormous efforts of the scientific community over the years, effective therapeutics for many (epi)genetic brain disorders remain unidentified. The common and persistent failures to translate preclinical findings into clinical success are partially attributed to the limited efficiency of current disease models. Although animal and cellular models have substantially improved our knowledge of the pathological processes involved in these disorders, human brain research has generally been hampered by a lack of satisfactory humanized model systems...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28511433/clinico-radiologic-and-spirometric-profile-of-an-indian-population-with-post-tuberculous-obstructive-airway-disease
#2
Avradip Santra, Pravati Dutta, Rekha Manjhi, Sudarsan Pothal
INTRODUCTION: Tuberculosis is a public health problem in developing countries and in spite of receiving adequate anti-tuberculous therapy, patients often continues to have several post-tuberculous sequelae, especially airflow limitation. AIM: To evaluate pulmonary function by spirometry among post-tuberculosis cases with airway obstruction and their relationship with smoking. MATERIALS AND METHODS: All patients who presented to the pulmonary medicine Outpatient Department (OPD) with symptoms of obstructive airway disease and had completed adequate anti-tuberculous therapy for pulmonary tuberculosis were taken up for study...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511308/-blood-borne-occupational-exposure-and-protection-in-medical-staff-of-a-traditional-chinese-medicine-hospital
#3
Z G Zhang, Q X Wei, Z P Yang, Q M Wei, X M Wang, X L Wang
Objective: To investigate blood-borne occupational exposure and related protection in the medical staff of a traditional Chinese medicine hospital, and to provide a reference for reducing the risk of blood-borne occupational exposure. Methods: Forty-eight medical workers with blood-borne occupational exposure in 2015 were selected to analyze the incidence of blood-borne occupational exposure, influencing factors, operations that caused blood-borne occupational exposure, pathogens, and occupational protection...
March 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28510639/toward-an-elucidation-of-the-molecular-genetics-of-inherited-retinal-degenerations
#4
G Jane Farrar, Matthew Carrigan, Adrian Dockery, Sophia Millington Ward, Arpad Palfi, Naomi Chadderton, Marian Humphries, Anna Sophia Kiang, Paul F Kenna, Pete Humphries
While individually classed as rare diseases, hereditary retinal degenerations (IRDs) are the major cause of registered visual handicap in the developed world. Given their hereditary nature, some degree of intergenic heterogeneity was expected, with genes segregating in autosomal dominant, recessive, X-linked recessive, and more rarely in digenic or mitochondrial modes. Today, it is recognized that IRDs, as a group, represent one of the most genetically diverse of hereditary conditions - at least 260 genes having been implicated, with 70 genes identified in the most common IRD, retinitis pigmentosa (RP)...
May 16, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28506901/new-isoflavonoids-from-the-extract-of-rhynchosia-precatoria-humb-bonpl-ex-willd-dc-and-their-antimycobacterial-activity
#5
Enrique Wenceslao Coronado-Aceves, Giulia Gigliarelli, Adriana Garibay-Escobar, Ramón Enrique Robles Zepeda, Massimo Curini, Jaime López Cervantes, Clara Inés Espitia-Pinzón, Stefano Superchi, Stefania Vergura, Maria Carla Marcotullio
ETHNOPHARMACOLOGY RELEVANCE: The evaluation of the antimycobacterial activity of extracts of medicinal plants used by Mayos against tuberculosis and respiratory problems, allowed the identification of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC (Fabaceae) as the best candidate to find new antimycobacterial compounds. AIM OF THE STUDY: To isolate and characterize the compounds of R. precatoria responsible for the inhibitory and bactericidal activity against Mycobacterium tuberculosis H37Rv and Mycobacterium smegmatis ATCC 700084...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28504874/cranioplasty-with-adipose-derived-stem-cells-beta-tricalcium-phosphate-granules-and-supporting-mesh-six-year-clinical-follow-up-results
#6
Tuomo Thesleff, Kai Lehtimäki, Tero Niskakangas, Sanna Huovinen, Bettina Mannerström, Susanna Miettinen, Riitta Seppänen-Kaijansinkko, Juha Öhman
Several alternative techniques exist to reconstruct skull defects. The complication rate of the cranioplasty procedure is high and the search for optimal materials and techniques continues. To report long-term results of patients who have received a cranioplasty using autologous adipose-derived stem cells (ASCs) seeded on beta-tricalcium phosphate (betaTCP) granules. Between 10/2008 and 3/2010, five cranioplasties were performed (four females, one male; average age 62.0 years) using ASCs, betaTCP granules and titanium or resorbable meshes...
May 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28504115/protocatechuic-acid-inhibits-hepatitis-b-virus-replication-by-activating-erk1-2-pathway-and-down-regulating-hnf4%C3%AE-and-hnf1%C3%AE-in-vitro
#7
Xiao-Qing Dai, Wen-Tao Cai, Xiao Wu, Yong Chen, Feng-Mei Han
AIMS: Protocatechuic acid (PCA) is a phenolic compound found in many antiviral Chinese herbal medicines. HNF4α and HNF1α, the members of hepatocyte nuclear factor (HNF) family, play an important regulatory role in the gene transcription of hepatitis B virus (HBV). Previous studies found that PCA inhibited HBV antigen secretion and HBV DNA replication in HepG2.2.15 cells, but its anti-HBV mechanism has not been fully understood. We aim to illustrate the anti-HBV mechanism of PCA. MATERIALS AND METHODS: MTT was used to estimate cytotoxicity...
May 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/28503759/evaluation-of-weight-change-during-carboplatin-therapy-in-dogs-with-appendicular-osteosarcoma
#8
A L Story, S E Boston, J J Kilkenny, A Singh, J P Woods, W T N Culp, K A Skorupski, X Lu
BACKGROUND: The prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients. OBJECTIVES: (1) To determine the patterns of weight change in dogs with appendicular osteosarcoma treated with amputation and single-agent carboplatin during the course of adjuvant chemotherapy; and (2) to determine whether postoperative weight change is a negative prognostic indicator for survival time in dogs with osteosarcoma...
May 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28502898/development-of-modified-release-3d-printed-tablets-printlets-with-pharmaceutical-excipients-using-additive-manufacturing
#9
Alvaro Goyanes, Fabrizio Fina, Annalisa Martorana, Daniel Sedough, Simon Gaisford, Abdul W Basit
The aim of this study was to manufacture 3D printed tablets (printlets) from enteric polymers by single filament fused deposition modeling (FDM) 3D printing (3DP). Hot melt extrusion was used to generate paracetamol-loaded filaments from three different grades of the pharmaceutical excipient hypromellose acetate succinate (HPMCAS), grades LG, MG and HG. One-step 3DP was used to process these filaments into enteric printlets incorporating up to 50% drug loading with two different infill percentages (20 and 100%)...
May 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28502521/-extracorporeal-life-support-in-thoracic-surgery-what-are-the-indications-and-the-pertinence
#10
REVIEW
J Reeb, A Olland, S Renaud, O Collange, X Delabranche, N Santelmo, F Meziani, P-M Mertes, G Massard, P-E Falcoz
INTRODUCTION: In thoracic surgery, extracorporeal life support (ECLS) technologies are used in cases of severe and refractory respiratory failure or as intraoperative cardiorespiratory support. The objectives of this review are to describe the rationale of ECLS techniques, to review the pulmonary diseases potentially treated by ECLS, and finally to demonstrate the efficacy of ECLS, using recently published data from the literature, in order to practice evidence based medicine. STATE OF THE ART: ECLS technologies should only be undertaken in expert centers...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28501181/a-voltammetry-sensor-platform-for-baicalein-and-baicalin-simultaneous-detection-in-vivo-based-on-ta2o5-nb2o5-cts-composite
#11
Zhengkun Xie, Wang Lu, Lingxi Yang, Gaiping Li, Baoxian Ye
Baicalein and baicalin are the major flavonoids found in Scutellariae Radix, an essential herb which has had a presence in traditional Chinese medicine (TCMs) for more than two thousands of years. Owing to their similar characteristics and physiochemical properties, sensitive, it is a great challenge to detect both of them simultaneously. In this work, a novel, facile and sensitive electrochemical method was proposed based on tantalum oxide (Ta2O5), niobium oxide (Nb2O5) particles and antiseptic chitosan modified carbon paste electrode (Ta2O5-Nb2O5@CTS-CPE)...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28500759/a-monte-carlo-model-for-mean-glandular-dose-evaluation-in-spot-compression-mammography
#12
Antonio Sarno, David R Dance, Ruben E van Engen, Kenneth C Young, Paolo Russo, Francesca Di Lillo, Giovanni Mettivier, Kristina Bliznakova, Baowei Fei, Ioannis Sechopoulos
PURPOSE: To characterize the dependence of normalized glandular dose (DgN) on various breast model and image acquisition parameters during spot compression mammography and other partial breast irradiation conditions, and evaluate alternative previously-proposed dose-related metrics for this breast imaging modality. METHODS: Using Monte Carlo simulations with both simple homogeneous breast models and patient-specific breasts, three different dose related metrics for spot compression mammography were compared: the standard DgN, the normalized glandular dose to only the directly irradiated portion of the breast (DgNv), and the DgN obtained by the product of the DgN for full field irradiation and the ratio of the mid-height area of the irradiated breast to the entire breast area (DgNM )...
May 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28497937/cone-beam-volumetric-imaging-in-craniofacial-medicine
#13
Dario Bertossi, Pietro Fiorino, Claudia Corega, Luca Sbricoli, Daniele DE Santis, Dario Donadello, Giulia Ricciardi, Umberto Luciano, Eriberto Bressan, Alessia Pardo, Massimo Albanese, Alessandro Zangani
With the development of x-ray computed tomography (CT) in the 1960s and its first use for clinical studies in 1972 by Sir Godfrey Hounsfield, radiological tomography attained widespread use and today is one of the essential imaging techniques in medical radiology. It is a technically mature and clinically widely accepted method and complements classical x-ray panoramic radiography in many areas. The technology is frequently used in craniofacial radiology, because of its characteristic low radiation dose, high spatial resolution and lower cost compared with CT...
May 12, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28495480/-fabien-arcelin-1876-1942-or-how-to-become-a-radiation-oncologist-when-born-an-archeologist
#14
N Foray
Fabien Arcelin, physician working in Lyon, pioneer of radiology and radiotherapy, was both mentored by Destot (one of the fathers of the French radiology for his thesis of medicine) and by his own father Adrien Arcelin (one of the two codiscoverers of the prehistorical site of the Roche-de-Solutré in Burgundy) for archeological works. Hence, radiologist in Lyon during the week and archeologist during the weekend, Fabien Arcelin made significant advances in both radiation research and archeology. He was notably the discoverer of the first tombs of Aurignacian men...
May 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28494543/-effects-of-anluohuaxianwan-on-transforming-growth-factor-%C3%AE-1-and-related-signaling-pathways-in-rats-with-carbon-tetrachloride-induced-liver-fibrosis
#15
W Lu, Y H Gao, Z Z Wang, Y S Cai, Y Q Yang, Y Q Miao, F Pei, X E Liu, H Zhuang
Objective: The traditional Chinese medicine Anluohuaxianwan (ALHXW) has been used to treat liver fibrosis induced by chronic hepatitis B virus (HBV) infection. However, the anti-fibrosis mechanisms of ALHXW remain to be investigated. This study used a rat model of carbon tetrachloride (CCl(4))-induced liver fibrosis to explore the potential antifibrogenic mechanisms of ALHXW. Methods: Twenty-seven male Wistar rats were randomly assigned to control group, model group, and treatment group (n = 9 per group). Rats in the model and treatment group were injected intraperitoneally with 40% CCl(4)(2 ml/kg), and rats in the control group were administered saline twice a week for 6 weeks...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28490330/comparative-measurements-of-bone-mineral-density-and-bone-contrast-values-in-canine-femora-using-dual-energy-x-ray-absorptiometry-and-conventional-digital-radiography
#16
K Lucas, I Nolte, V Galindo-Zamora, M Lerch, C Stukenborg-Colsman, B A Behrens, A Bouguecha, S Betancur, A Almohallami, P Wefstaedt
BACKGROUND: Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo...
May 11, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28485976/use-of-nanoparticle-contrast-agents-for-cell-tracking-with-computed-tomography
#17
Johoon Kim, Peter Chhour, Jessica Hsu, Harold I Litt, Victor A Ferrari, Rachela Popovtzer, David P Cormode
Efforts to develop novel cell-based therapies originated with the first bone marrow transplant on a leukemia patient in 1956. Preclinical and clinical examples of cell-based treatment strategies have shown promising results across many disciplines in medicine, with recent advances in immune cell therapies for cancer producing remarkable response rates, even in patients with multiple treatment failures. However, cell-based therapies suffer from inconsistent outcomes, motivating the search for tools that allow monitoring cell delivery and behavior in vivo...
May 9, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28482596/surface-roughness-in-action-cells-in-opposition
#18
P Slepička, I Michaljaničová, S Rimpelová, V Švorčík
Aim of this work is to study the interaction of krypton fluoride (KrF) excimer laser beam with a biopolymer and creation of new nanostructures with great potential for cell growth guidance. As a substrate we used biocompatible and biodegradable polymer polyhydroxybutyrate, which is frequently used in medicine and drug delivery system. Modification was carried out by KrF laser and method was also supplemented by treatment with Ar(+) plasma. The changes in physico-chemical properties of surface layer were determined by goniometry, gravimetry and X-ray photoelectron spectroscopy (XPS)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482435/-expression-of-nf-%C3%AE%C2%BAb-in-a-degenerative-human-intervertebral-disc-model
#19
X F Wang, A P Zhang, Z Y Sun, C Liu, L H Kuang, J W Tian
Objective: To investigate the changes in the expression of NF-κB signaling pathway in human degenerative intervertebral discs. Methods: From October 2014 to March 2016, 55 nucleus pulposus of surgical patients with degenerative human intervertebral disc were collected for study in Department of Orthopedic Surgey, Hospital of Zaozhuang Mining Corporation, and Department of Orthopedics, Shanghai General Hospital Affiliated Shanghai Jiaotong University, School of Medicine.The collected nucleus pulposus tissues were divided into two groups: experimental group(30) and control group(25)...
May 9, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28482432/-quick-confirmation-of-nasointestinal-tube-placed-below-pylorus-in-critically-ill-patients-by-duodenal-bulb-ultrasonic-anatomy-locating-method
#20
R Z Ye, X M Fan, R H Sun, F Zhang, L G Wang, Z Zeng, Y Liu, B C Hu, Y X Tu
Objective: To investigate the value of duodenal bulb ultrasonic anatomy locating method quickly confirm nasointestinal tube placed below pylorus in critically ill patients. Methods: A total of 56 critically ill patients with nasointestinal tube posting surgery by blindly inserting method were collected from March 1 st, 2016 to August 1 st, 2016 in the Department of Critical Care Medicine of Zhejiang Provincial People's Hospital.In these patients, the duodenal bulbs were rapidly detected and located by ultrasonic anatomy locating method and at the same time observed whether nasointestinal tube echogram were in them or not...
May 9, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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