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Amanda Nikolic, Nilmini Wickramasinghe, Damian Claydon-Platt, Vikram Balakrishnan, Philip Smart
BACKGROUND: The use of communication apps on mobile phones offers an efficient, unobtrusive, and portable mode of communication for medical staff. The potential enhancements in patient care and education appear significant, with clinical details able to be shared quickly within multidisciplinary teams, supporting rapid integration of disparate information, and more efficient patient care. However, sharing patient data in this way also raises legal and ethical issues. No data is currently available demonstrating how widespread the use of these apps are, doctor's attitudes towards them, or what guides clinician choice of app...
February 9, 2018: JMIR Medical Informatics
Fengxian Sun, Shumei Xu, Fang Jiang, Weiying Liu
Clethramycin (1) and mediomycin A (2) belong to the linear polyene polyketide (LPP) family of antibiotics that exhibit potent antifungal activity. Structural similarities exist between 1 and 2, except that 2 contains an amino moiety substituted for the guanidino moiety. Herein, the draft genome sequence of Streptomyces mediocidicus ATCC23936, a strain which produces both 1 and 2, was obtained through de novo sequencing. Bioinformatic analysis of the genome revealed a clethramycin (cle) gene cluster that contained 25 open reading frames (orfs)...
March 2018: Applied Microbiology and Biotechnology
Sungbum Ju
[Purpose] The purpose of this study was to investigate the effects of short-term lumbar stability cross taping program on muscle strength of trunk extension and lumbar pain level in patients with chronic back pain. [Subjects and Methods] The present study divided 14 patients with chronic back pain into the stability cross taping group (SCTG; n=7) and the control group (CONG; n=7). Lumbar cross taping was applied to SCTG for 7 days, but the taping was not applied to CONG. After 7 days of the lumbar stability cross taping application to SCTG, lumbar muscle function and lumbar pain levels were measured using a Medx lumbar extension machine (Medx, USA) and a visual analogue scale (VAS) for the subjects in both SCTG and CONG...
October 2017: Journal of Physical Therapy Science
Wenli Cai, Seth M Steinberg, Miriam A Bredella, Gina Basinsky, Bhanusupriya Somarouthu, Scott R Plotkin, Jeffrey Solomon, Brigitte C Widemann, Gordon J Harris, Eva Dombi
OBJECTIVES: Plexiform neurofibromas (PNs) are complex, histologically benign peripheral nerve sheath tumors that are challenging to measure by simple line measurements. Computer-aided volumetric segmentation of PN has become the recommended method to assess response in clinical trials directed at PN. Different methods for volumetric analysis of PN have been developed. The goal of this study is to test the level of agreement in volume measurements and in interval changes using two separate methods of volumetric magnetic resonance imaging analysis...
February 2018: Academic Radiology
Anisha Veeren, Archana Bhaw-Luximon, Debabrata Mukhopadhyay, Dhanjay Jhurry
We report in this paper on the enhanced efficacy of a physical mixture of two single anti-cancer loaded nanomicelles against PANC-1 and BxPC-3. Poly(vinyl pyrrolidone-b-polycaprolactone) (PVP-b-PCL) and poly(vinyl pyrrolidone-b-poly(dioxanone-co-methyl dioxanone)) (PVP-b-P(DX-co-MeDX)) were synthesized and successfully loaded with various anti-cancer drugs - gemcitabine (GEM), doxorubicin.HCl (DOX.HCl), doxorubicin.NH2 (DOX), 5-fluorouracil (5-FU) and paclitaxel (PTX). Spherical micelles of size 160-477 nm were obtained as characterized by DLS while sizes determined by TEM were in the range 140-250 nm...
May 1, 2017: European Journal of Pharmaceutical Sciences
Jaeyong Park, Jung Chul Lee
[Purpose] The purpose of this study was to assess the effects of complex rehabilitation training on chronic low back pain. [Subjects and Methods] Complex rehabilitation training for lumbar isometric muscle strength was conducted for 12 weeks for males (n=10) and females (n=10) with chronic low back pain, who were aged in their 30s. [Results] Isometric strength of lumbar extension was increased post-test, and significant differences were found between males and females, at MedX angle of 0, 48, and 60. [Conclusion] This study showed that complex rehabilitation training had a beneficial effect on the muscle strength of lumbar extension in patients with chronic low back pain...
November 2016: Journal of Physical Therapy Science
Jena B Ogston, Richard D Crowell, Brian K Konowalchuk
BACKGROUND: Approaches in the treatment of general chronic low back pain (CLBP) are multifaceted relative to specific interventions. In the past, passive interventions have commonly been employed with little evidence to support their effectiveness. Recent reviews suggest a focus on active exercises programs that includes pain education and cognitive behavioral therapy. OBJECTIVE: To investigate the outcomes of CLBP patients and describe the approach in persons undergoing a group spinal rehabilitation program using graded exercise, and operant conditioning...
November 21, 2016: Journal of Back and Musculoskeletal Rehabilitation
Nowsheen Goonoo, Roubeena Jeetah, Archana Bhaw-Luximon, Dhanjay Jhurry
Since the commercialization of polydioxanone (PDX) as a biodegradable monofilament suture by Ethicon in 1981, the polymer has received only limited interest until recently. The limitations of polylactide-co-glycolide (PLGA) coupled with the growing need for materials with enhanced features and the advent of new fabrication techniques such as electrospinning have revived interest for PDX in medical devices, tissue engineering and drug delivery applications. Electrospun PDX mats show comparable mechanical properties as the major structural components of native vascular extracellular matrix (ECM) i...
November 2015: European Journal of Pharmaceutics and Biopharmaceutics
Young-Ki Cho, Dae-Young Kim, Sun-Young Jung, Jun-Hyuk Seong
[Purpose] The present study examined the influence of treadmill exercise added to a low back pain rehabilitation program on low back extensor strength, pain, and dysfunction in chronic low back pain patients. [Subjects and Methods] Twenty men aged 22-36 years with chronic low back pain were randomly divided into experimental and control groups of 10 patients each. Both groups underwent a low back pain rehabilitation program lasting 30 min each, thrice/week for 8 weeks. The experimental group was prescribed an additional 30 min of treadmill exercise without a slope at a speed of 3...
April 2015: Journal of Physical Therapy Science
Kristine M Knutson, Olga Dal Monte, Selene Schintu, Eric M Wassermann, Vanessa Raymont, Jordan Grafman, Frank Krueger
Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer's disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe's involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior...
2015: Journal of Neuropsychiatry and Clinical Neurosciences
So Hee Lee, Tae Hoon Kim, Byoung Hee Lee
[Purpose] The purpose of this study was to investigate the effects of abdominal bracing with low extremity movement on changes in thickness of abdominal muscles and lumbar strength. [Subjects] Sixteen patients with chronic low back pain were randomly assigned to two groups: an abdominal bracing with active straight leg raise (ABSLR) group and abdominal bracing with ankle dorsiflexion (ABDF) group. [Methods] All subjects were evaluated for their abdominal muscle strength using a MedX Lumbar Extension Machine and thickness of external oblique (EO), internal oblique (IO), and transverse abdominis (TrA) muscles using rehabilitative ultrasound imaging...
January 2014: Journal of Physical Therapy Science
James Fisher, Stewart Bruce-Low, Dave Smith
OBJECTIVE: To consider the efficacy of 10 weeks of Romanian deadlift (DL) training in increasing lumbar extension strength compared to isolated lumbar extension (LUMX) training. DESIGN: Comparison of pre- and post-test data for Romanian deadlift 1RM, and lumbar extension torque between and within groups. PARTICIPANTS: Male trained subjects (n = 36; (x¯±SD) 24.9 ± 6.5 years; 178.5 ± 5.2 cm; 81.6 ± 10.0 kg). MAIN OUTCOME MEASURES: Pre- and post-testing included a Romanian deadlift 1RM and isometric strength tests every 12° through full range of motion on the MedX lumbar extension machine (MedX, Ocala, FL)...
August 2013: Physical Therapy in Sport
Hye Jin Moon, Kyoung Hyo Choi, Dae Ha Kim, Ha Jeong Kim, Young Ki Cho, Kwang Hee Lee, Jung Hoo Kim, Yoo Jung Choi
OBJECTIVE: To compare the effects of lumbar stabilization exercises and lumbar dynamic strengthening exercises on the maximal isometric strength of the lumbar extensors, pain severity and functional disability in patients with chronic low back pain (LBP). METHODS: Patients suffering nonspecific LBP for more than 3 months were included prospectively and randomized into lumbar stabilization exercise group (n=11) or lumbar dynamic strengthening exercise group (n=10)...
February 2013: Annals of Rehabilitation Medicine
Geoffrey K Aguirre
The early years of BOLD fMRI coincided with the rapid growth of both the internet and the open-source software movement. This environment encouraged the creation and dissemination of many neuroimaging software projects, only some of which survived. I tell the story of two of these open-source projects, FIASCO and VoxBo, as well as the interesting links between the commercial MedX software deployed at the NIH and satellite reconnaissance.
August 15, 2012: NeuroImage
Dave Smith, Gary Bissell, Stewart Bruce-Low, Caroline Wakefield
INTRODUCTION: A dynamometer employing a stabilization procedure (lumbar extension machine, MedX, Ocala, FL) is effective in improving strength and reducing symptoms of low back pain (LBP), and researchers have hypothesized that this effectiveness is due to the pelvic stabilization. However, effects of the dynamometer with and without pelvic stabilization on LBP have not been compared: This was the aim of the present study. METHODS: Forty-two chronic LBP patients were randomly assigned to a lumbar extension training with pelvic stabilization group (STAB; n=15), a lumbar extension without pelvic stabilization group (NO-STAB; n=15) and a control group (n=12)...
2011: Journal of Back and Musculoskeletal Rehabilitation
Rosa Nguyen, Lan Kluwe, Carsten Fuensterer, Michael Kentsch, Reinhard Edgar Friedrich, Victor-Felix Mautner
OBJECTIVES: To define the frequency and clinical features of plexiform neurofibromas (PN) in children with neurofibromatosis type 1. STUDY DESIGN: Sixty-five children received whole-body magnetic resonance imaging (MRI) and clinical-neurologic examination. Tumor sizes were calculated volumetrically with the program MedX v3.42. χ(2) test, Fisher exact test, t test, and Spearman rank correlation were used for statistical analysis. RESULTS: Seventy-three tumors were detected in 37 of these 65 children...
October 2011: Journal of Pediatrics
Daniela Proverbio, Debora Groppetti, Eva Spada, Roberta Perego
BACKGROUND: Serum cortisol concentration is often measured in dogs for the diagnosis and monitoring of adrenal disease. An enzyme-linked fluorescent assay (VIDAS method) on the MiniVidas analyzer has been validated for the measurement of cortisol concentration in human serum and could have applications for canine samples. OBJECTIVE: The aim of this study was to compare canine cortisol results obtained using the VIDAS method with those obtained using the IMMULITE-2000 immunoassay, which has previously been validated for canine serum...
September 2009: Veterinary Clinical Pathology
Deeya Gaindh, Neal Jeffries, Joan Ohayon, Nancy D Richert, Clelia Pellicano, Joseph A Frank, Henry McFarland, Francesca Bagnato
BACKGROUND: Contrast enhancing lesions (CELs) in MRI represent inflammatory events in multiple sclerosis (MS). IFN-beta-1b decreases the formation of CELs. However, the ability of IFN-beta-1b to reduce the size of CELs arising during therapy has not been extensively investigated. METHODS: Thirty patients with relapsing-remitting (RR) MS were followed for a 3-month pre-therapy phase then for a 6-month therapy phase during which treatment with IFN-beta-1b at a dosage of 250 microg subcutaneously injected every other day was employed...
December 2008: Expert Opinion on Biological Therapy
J E Graves, C K Fix, M L Pollock, S H Leggett, D N Foster, D M Carpenter
This study was supported in part by a grant from MedX Inc., Ocala, FL. Among strength testing methods, varying degrees of stabilization are used. The purpose of this study was to compare isometric lumbar extension strength values obtained from two different restraint systems designed to isolate the lumbar extensors through pelvic stabilization. Both restraint systems stabilized the pelvis by preventing movement of the lower extremities during testing with the subject in a seated position. One restraint system (KNEE) applied pressure just below the knees while the lower leg was positioned at 120 degrees of knee flexion...
1992: Journal of Orthopaedic and Sports Physical Therapy
Dániel Székács, Ibolya Bodnár, György M Nagy, Márton I K Fekete
The endogenous isoquinoline salsolinol (SALS) is a recently identified prolactin (PRL) releasing factor, a selective and potent stimulator of PRL secretion both in vivo and in vitro. SALS decreased the peripheral tissue dopamine (DA) level dose dependently, consequently increased the NE/DA ratio, indicating reduced release of newly formed norepinephrine (NE) from sympathetic terminals. The aim of our study was to investigate the effect of adrenal medullectomy (MEDX), adrenalectomy (ADX) and hypophysectomy (HYPOX) on the action of SALS on the PRL secretion, and on the catecholamine concentration of the selected sympathetically innervated peripheral tissues (atrium, spleen, etc)...
March 30, 2007: Ideggyógyászati Szemle
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