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https://www.readbyqxmd.com/read/27905621/-parechovirus-as-etiologic-agent-of-meningitis-and-or-sepsis-like-illness-in-infants
#1
Valentina Gutiérrez, Constanza Martínez-Valdebenito, Luisa Montecinos, Romina Alarcón, Constanza Gárate, Marcela Ferrés
INTRODUCTION: Human parechovirus (HPeV) belongs to the Picornaviridae family and has been described in viral meningoencephalitis and sepsis like illness in infants. Until now, 16 genotypes have been recognized, the most common are HPEV 1, 2 and 3; type 3 is most severe. AIMS: To estimate the frequency of HPEV etiology in viral meningoencephalitis and sepsis in infants and characterize clinical and molecular aspects of infection. METHODS: Between October 2013 and March 2015 we collected CSF samples, plasma, nasopharyngeal swabs and/or stools of patients younger than two years with suspected sepsis and/or viral meningitis...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27905556/cellular-aspartyl-proteases-promote-the-unconventional-secretion-of-biologically-active-hiv-1-matrix-protein-p17
#2
Francesca Caccuri, Maria Luisa Iaria, Federica Campilongo, Kristen Varney, Alessandro Rossi, Stefania Mitola, Silvia Schiarea, Antonella Bugatti, Pietro Mazzuca, Cinzia Giagulli, Simona Fiorentini, Wuyuan Lu, Mario Salmona, Arnaldo Caruso
The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in different organs and tissues even in HIV-1-infected patients undergoing successful combined antiretroviral therapy (cART). Extracellularly, p17 deregulates the function of different cells involved in AIDS pathogenesis. The mechanism of p17 secretion, particularly during HIV-1 latency, still remains to be elucidated. A recent study showed that HIV-1-infected cells can produce Gag without spreading infection in a model of viral latency...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905485/b-and-t-lymphocyte-number-and-function-in-hiv-hiv-lymphoma-patients-treated-with-high-dose-chemotherapy-and-autologous-bone-marrow-transplantation
#3
Diego Bertoli, Alessandro Re, Marco Chiarini, Alessandra Sottini, Federico Serana, Viviana Giustini, Aldo M Roccaro, Chiara Cattaneo, Luigi Caimi, Giuseppe Rossi, Luisa Imberti
Combination of anti-retroviral therapy, high-dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) has led to an improved survival of HIV(+) non-Hodgkin lymphoma (NHL) patients. We compared T- and B-cell subset recovery and related capability to respond to in-vitro stimulation, as well as T-cell repertoire modifications of HIV(+) and HIV(-) NHL patients undergoing HCT and ASCT as first-line consolidation or salvage treatment, using sequential blood samples obtained before and at 3, 6, 12 and 24 months after ASCT...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903921/a-two-pool-model-to-describe-the-ivim-cerebral-perfusion
#4
Gabrielle Fournet, Jing-Rebecca Li, Alex M Cerjanic, Bradley P Sutton, Luisa Ciobanu, Denis Le Bihan
IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm(2) at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model...
November 30, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27903240/central-line-associated-bloodstream-infections-in-a-tertiary-care-children-s-university-hospital-a-prospective-study
#5
Elisabetta Venturini, Carlotta Montagnani, Alessandra Benni, Sabrina Becciani, Klaus Peter Biermann, Salvatore De Masi, Elena Chiappini, Maurizio de Martino, Luisa Galli
BACKGROUND: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27903128/postoperative-outcome-of-body-core-temperature-rhythm-and-sleep-wake-cycle-in-third-ventricle-craniopharyngiomas
#6
Matteo Zoli, Luisa Sambati, Laura Milanese, Matteo Foschi, Marco Faustini-Fustini, Gianluca Marucci, Dario de Biase, Giovanni Tallini, Annagrazia Cecere, Francesco Mignani, Carmelo Sturiale, Giorgio Frank, Ernesto Pasquini, Pietro Cortelli, Diego Mazzatenta, Federica Provini
OBJECTIVE One of the more serious risks in the treatment of third ventricle craniopharyngiomas is represented by hypothalamic damage. Recently, many papers have reported the expansion of the indications for the endoscopic endonasal approach (EEA) to be used for these tumors as well. The aim of this study was to assess the outcome of sleep-wake cycle and body core temperature (BCT), both depending on hypothalamic control, in patients affected by craniopharyngiomas involving the third ventricle that were surgically treated via an EEA...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27902814/trends-in-surgical-treatment-of-breast-cancer-in-the-veterans-affairs-system
#7
Tyler A Evans, Stephen Duquette, Tahereh Soleimani, Luisa F Christensen, Imtiaz Munshi, Adam Cohen, Sunil S Tholpady
No abstract text is available yet for this article.
November 30, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27902759/seroprevalence-and-associated-factors-of-9-valent-human-papillomavirus-hpv-types-among-men-in-the-multinational-him-study
#8
Shams Rahman, Christine M Pierce Campbell, Dana E Rollison, Wei Wang, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Anna R Giuliano
BACKGROUND: Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Recently a 9-valent HPV (9vHPV) prophylactic vaccine was licensed. Seroprevalence prior to vaccine dissemination is needed for monitoring vaccine effectiveness over time. Few studies have assessed the seroprevalence of 9vHPV types in men. OBJECTIVES: To investigate the seroprevalence of 9vHPV vaccine types and associated risk factors among men residing in Brazil, Mexico, and the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27902751/exploration-of-a-polygenic-risk-score-for-alcohol-consumption-a-longitudinal-analysis-from-the-alspac-cohort
#9
Michelle Taylor, Andrew J Simpkin, Philip C Haycock, Frank Dudbridge, Luisa Zuccolo
BACKGROUND: Uncertainty remains about the true extent by which alcohol consumption causes a number of health outcomes. Genetic variants, or combinations of variants built into a polygenic risk score (PGRS), can be used in an instrumental variable framework to assess causality between a phenotype and disease outcome of interest, a method known as Mendelian randomisation (MR). We aimed to identify genetic variants involved in the aetiology of alcohol consumption, and develop a PGRS for alcohol...
2016: PloS One
https://www.readbyqxmd.com/read/27902363/seroprevalence-of-cutaneous-human-papillomaviruses-hpv-among-men-in-the-multinational-him-study
#10
Shams Rahman, Christine M Pierce Campbell, Tim Waterboer, Dana E Rollison, Donna J Ingles, B Nelson Torres, Angelika Michel, Staci L Sudenga, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Wei Wang, Anna R Giuliano
Data on cutaneous HPV seroprevalence is primarily derived from skin cancer case-controls studies. Few studies have reported the seroprevalence of cutaneous HPV among healthy men. This study investigated the seroprevalence of cutaneous HPV types and associated risk factors among men residing in Brazil, Mexico, and the United States. Six hundred men were randomly selected from the HPV Infection in Men (HIM) Study. Archived serum specimens were tested for antibodies against 14 cutaneous HPV genotypes, β-HPV types (5/8/12/14/17/22/23/24/38/48), α-HPV 27, γ-HPV 4, µ-HPV1 and ν-HPV 41 using a GST L1-based multiplex serology assay...
October 6, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902229/citrobacter-europaeus-sp-nov-a-novel-citrobacter-species-isolated-from-water-and-human-faecal-samples
#11
Sylvain Brisse, Teresa G Ribeiro, Dominique Clermont, Raquel Branquinho, Elisabete Maria Pereira Machado, Luisa Peixe
Strains 97/79T and A121, recovered respectively from human faeces and well waters, were compared to currently known Citrobacter species using genotypic and phenotypic approaches. Multilocus sequence analysis based on housekeeping genes fusA, leuS, pyrG, rpoB and recN genes, showed that the two strains formed a distinct phylogenetic lineage within the Citrobacter genus. Average nucleotide identity (ANI) between strains 97/79T and A121 was 99.2%, whereas ANI values of 97/79T with the type strains of closely related Citrobacter species C...
October 25, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900420/nmr-based-metabolomic-approach-to-study-urine-samples-of-chronic-inflammatory-rheumatic-disease-patients
#12
Alessia Vignoli, Donatella Maria Rodio, Anna Bellizzi, Anatoly Petrovich Sobolev, Elena Anzivino, Monica Mischitelli, Leonardo Tenori, Federico Marini, Roberta Priori, Rossana Scrivo, Guido Valesini, Ada Francia, Manuela Morreale, Maria Rosa Ciardi, Marco Iannetta, Cristiana Campanella, Donatella Capitani, Claudio Luchinat, Valeria Pietropaolo, Luisa Mannina
The nuclear magnetic resonance (NMR)-based metabolomic approach was used as analytical methodology to study the urine samples of chronic inflammatory rheumatic disease (CIRD) patients. The urine samples of CIRD patients were compared to the ones of both healthy subjects and patients with multiple sclerosis (MS), another immuno-mediated disease. Urine samples collected from 39 CIRD patients, 25 healthy subjects, and 26 MS patients were analyzed using (1)H NMR spectroscopy, and the NMR spectra were examined using partial least squares-discriminant analysis (PLS-DA)...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27899630/european-nucleotide-archive-in-2016
#13
Ana Luisa Toribio, Blaise Alako, Clara Amid, Ana Cerdeño-Tarrága, Laura Clarke, Iain Cleland, Susan Fairley, Richard Gibson, Neil Goodgame, Petra Ten Hoopen, Suran Jayathilaka, Simon Kay, Rasko Leinonen, Xin Liu, Josué Martínez-Villacorta, Nima Pakseresht, Jeena Rajan, Kethi Reddy, Marc Rosello, Nicole Silvester, Dmitriy Smirnov, Daniel Vaughan, Vadim Zalunin, Guy Cochrane
The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/ena) offers a rich platform for data sharing, publishing and archiving and a globally comprehensive data set for onward use by the scientific community. With a broad scope spanning raw sequencing reads, genome assemblies and functional annotation, the resource provides extensive data submission, search and download facilities across web and programmatic interfaces. Here, we outline ENA content and major access modalities, highlight major developments in 2016 and outline a number of examples of data reuse from ENA...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898463/transplantation-tolerance-after-allograft-rejection
#14
Michelle L Miller, Maria-Luisa Alegre, Anita S Chong
PURPOSE OF REVIEW: Although elusive for many decades, transplantation tolerance can now be achieved in the clinic. This has prompted follow-up investigations into its stability and longevity, as well as into barriers to its induction, which include memory T and B cells. RECENT FINDINGS: Clinical observations reveal that transplantation tolerance can be induced in adult recipients and that even episodes of acute rejection do not preclude successful weaning from immunosuppression to reveal tolerance...
November 24, 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27897054/high-levels-of-inflammatory-cytokines-in-the-reproductive-tract-of-women-with-bv-and-engaging-in-intravaginal-douching-a-cross-sectional-study-of-participants-in-the-women-interagency-hiv-study-wihs
#15
Maria Luisa Alcaide, Violeta J Rodriguez, Megan R Brown, Suresh Pallikkuth, Kristopher Arheart, Octavio Martinez, Margaret Roach, Raina Fichorova, Deborah L Jones, Savita Pahwa, Margaret A Fischl
High levels of inflammatory cytokines in the genital tract suggest mucosal vulnerability and increased risk of HIV and STI acquisition. Intravaginal douching is associated with bacterial vaginosis (BV) in women in the US, and both douching and BV are linked to HIV and STI acquisition. This study evaluates inflammatory cytokines in the genital tract to increase understanding of the effects of both BV and intravaginal douching to the vaginal mucosa. A cross-sectional study of participants in the Miami WIHS investigated 72 reproductive age women (45 HIV+ and 27 high-risk HIV-) who completed intravaginal douching questionnaires and underwent collection of vaginal swabs and cervicovaginal lavages (CVL)...
November 29, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27896940/empowering-women-to-breastfeed-does-the-baby-friendly-initiative-make-a-difference
#16
Danielle Groleau, Katherine W Pizarro, Luisa Molino, Katherine Gray-Donald, Sonia Semenic
The Baby-Friendly Hospital Initiative (BFI) is currently presented worldwide as the gold standard model of care for promoting and supporting breastfeeding. However, there is a lack of understanding about the ways in which health services, including the BFI, address the cultural change from a disembodied practice (formula feeding) to an embodied one (breastfeeding) in contexts where formula feeding is the norm. We used a qualitative case study methodology to compare the embodied experience of breastfeeding and the maternal experience of breastfeeding promotion and support services between mothers receiving care from institutions with low and high levels of BFI implementation in Québec, Canada...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27896550/global-trends-of-monitoring-and-data-collection-on-the-hiv-response-among-key-populations-since-the-2001-un-declaration-of-commitment-on-hiv-aids
#17
Julia Gall, Keith Sabin, Luisa Frescura, Miriam Lewis Sabin, Taavi Erkkola, Igor Toskin
Monitoring and evaluation indicators for HIV programs' response to the epidemic among key populations (sex workers, people who inject drugs, men who have sex with men, transgender people) are critical for reviewing the global response. From the beginning of global reporting, insufficiency of data has been a challenge for monitoring the epidemic response among key populations. However, key populations were only indirectly referenced in the 2001 Declaration of Commitment. By the 2006 Political Declaration on HIV/AIDS, data from key populations were still not required from every country, and were sparsely reported compared to other indicators...
November 28, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27896418/effects-of-two-different-removable-functional-appliances-on-depth-of-the-posterior-airway-space-a-retrospective-cephalometric-study
#18
Jan Hourfar, Gero Stefan Michael Kinzinger, Luisa Katharina Meißner, Jörg Alexander Lisson
OBJECTIVES: Aim of the study was the comparison of treatment effects upon pharyngeal depth in patients treated with either (1) S-II-appliance or (2) Activator. METHODS: Pre- and posttreatment lateral cephalograms of 73 patients were analyzed using a customized set of measurements. According to predefined criteria, patients were either treated with S-II-appliance or Activator. Pharyngeal depth was assessed from cranial to caudal at six levels (P1 to P6). Paired t tests were used for intragroup and t tests for independent samples for intergroup comparisons...
November 28, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27894987/a-novel-approach-for-dry-powder-coating-of-pellets-with-ethylcellulose-part-i-evaluation-of-film-formulation-and-process-set-up
#19
Beatrice Albertini, Serena Bertoni, Cecilia Melegari, Luisa Stella Dolci, Nadia Passerini
An innovative dry powder coating technology was developed in a high-shear granulator using ethylcellulose (E10) as polymer. Several solid plasticizers were investigated with the aim of decreasing the polymer Tg at least to the highest possible working temperature (80°C). DSC analysis of physical mixtures of E10 and plasticizers evidenced that lauric acid (LA) was the most effective plasticizer. In order to reach the target temperature a liquid plasticizer, oleic acid (OA), was introduced in the coating formulation...
November 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27894860/pediatric-ovarian-torsion-and-its-recurrence-a-multicentric-study
#20
Mirko Bertozzi, Ciro Esposito, Claudio Vella, Vito Briganti, Nicola Zampieri, Daniela Codrich, Michele Ubertazzi, Alessandro Trucchi, Elisa Magrini, Sonia Battaglia, Vittorio Bini, Maria Luisa Conighi, Caterina Gulia, Alessandra Farina, Francesco Saverio Camoglio, Waifro Rigamonti, Piergiorgio Gamba, Giovanna Riccipetitoni, Salvatore Fabio Chiarenza, Alessandro Inserra, Antonino Appignani
STUDY OBJECTIVE: to report results of a retrospective multicentric Italian survey concerning the management of pediatric ovarian torsion (OT) and its recurrence. DESIGN: Multicentric retrospective cohort study. SETTING: Italian Units of Pediatric Surgery. PARTECIPANTS: Females 1<years-old<14 with surgically diagnosed OT between 2004-2014 . INTERVENTIONS: Adnexal detorsion, adnexectomy, mass excision by laparoscopy or laparotomy...
November 25, 2016: Journal of Pediatric and Adolescent Gynecology
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