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Brian Ball

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https://www.readbyqxmd.com/read/29550430/changes-in-the-stability-and-biomechanics-of-p22-bacteriophage-capsid-during-maturation
#1
Ravi Kant, Aida Llauró, Vamseedhar Rayaprolu, Shefah Qazi, Pedro J de Pablo, Trevor Douglas, Brian Bothner
The capsid of P22 bacteriophage undergoes a series of structural transitions during maturation that guide it from spherical to icosahedral morphology. The transitions include the release of scaffold proteins and capsid expansion. Although P22 maturation has been investigated for decades, a unified model that incorporates thermodynamic and biophysical analyses is not available. A general and specific model of icosahedral capsid maturation are of significant interest to theoreticians searching for fundamental principles as well as virologists and material scientists seeking to alter maturation to their advantage...
March 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29541162/three-dimensional-quantitative-analysis-of-healthy-foot-shape-a-proof-of-concept-study
#2
Kristina Stanković, Brian G Booth, Femke Danckaers, Fien Burg, Philippe Vermaelen, Saartje Duerinck, Jan Sijbers, Toon Huysmans
Background: Foot morphology has received increasing attention from both biomechanics researches and footwear manufacturers. Usually, the morphology of the foot is quantified by 2D footprints. However, footprint quantification ignores the foot's vertical dimension and hence, does not allow accurate quantification of complex 3D foot shape. Methods: The shape variation of healthy 3D feet in a population of 31 adult women and 31 adult men who live in Belgium was studied using geometric morphometric methods...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#3
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29239761/deflate-to-extricate-a-technique-for-rectal-foreign-body-removal-of-inflatable-ball
#4
Elizabeth C Robinson, David Roy, Brian E Driver
BACKGROUND: Rectal foreign bodies are commonly encountered in the emergency department (ED). Three techniques are well described in literature, including using a Foley catheter, "scooping" the object out, or grasping the object directly with ring forceps. We present a novel extraction method for an inflatable foreign body. CASE REPORT: A 27-year-old man presented to the ED 13 h after inserting a rubber inflatable child's ball into his rectum. After well-described extraction techniques failed to remove the ball, an 18-gauge needle at the end of a syringe was inserted into the rectum to puncture the ball and partially deflate it...
February 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29177761/chromatin-remodelling-proteins-and-cell-fate-decisions-in-mammalian-preimplantation-development
#5
Anzy Miller, Brian Hendrich
The very first cell divisions in mammalian embryogenesis produce a ball of cells, each with the potential to form any cell in the developing embryo or placenta. At some point, the embryo produces enough cells that some are located on the outside of the embryo, while others are completely surrounded by other cells. It is at this point that cells undergo the very first lineage commitment event: outer cells form the trophectoderm and lose the potential to form embryonic lineages, while inner cells form the Inner Cell Mass, which retain embryonic potential...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29135365/deep-learning-to-classify-radiology-free-text-reports
#6
Matthew C Chen, Robyn L Ball, Lingyao Yang, Nathaniel Moradzadeh, Brian E Chapman, David B Larson, Curtis P Langlotz, Timothy J Amrhein, Matthew P Lungren
Purpose To evaluate the performance of a deep learning convolutional neural network (CNN) model compared with a traditional natural language processing (NLP) model in extracting pulmonary embolism (PE) findings from thoracic computed tomography (CT) reports from two institutions. Materials and Methods Contrast material-enhanced CT examinations of the chest performed between January 1, 1998, and January 1, 2016, were selected. Annotations by two human radiologists were made for three categories: the presence, chronicity, and location of PE...
November 13, 2017: Radiology
https://www.readbyqxmd.com/read/29041129/particle-particle-interactions-in-large-sparse-arrays-of-randomly-distributed-plasmonic-metal-nanoparticles-a-two-particle-model
#7
Emil H Eriksen, Brian Julsgaard, Søren P Madsen, Harish Lakhotiya, Adnan Nazir, Peter Balling
A two-particle model is proposed which enables the assessment of particle-particle interactions in large, sparse arrays of randomly distributed plasmonic metal nanoparticles of arbitrary geometry in inhomogeneous environments. The two-particle model predicts experimentally observed peak splittings in the extinction cross section spectrum for randomly distributed gold nanocones on a TiO2 :Er3+ thin film with average center-to-center spacings of 3-5 diameters. The main physical mechanism responsible is found to be interference between the incident field and the far-field component of the single-particle scattered field which is guided along the film...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/28971011/structurofunctional-resting-state-networks-correlate-with-motor-function-in-chronic-stroke
#8
Benjamin T Kalinosky, Reivian Berrios Barillas, Brian D Schmit
PURPOSE: Motor function and recovery after stroke likely rely directly on the residual anatomical connections in the brain and its resting-state functional connectivity. Both structural and functional properties of cortical networks after stroke are revealed using multimodal magnetic resonance imaging (MRI). Specifically, functional connectivity MRI (fcMRI) can extract functional networks of the brain at rest, while structural connectivity can be estimated from white matter fiber orientations measured with high angular-resolution diffusion imaging (HARDI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28955711/environmental-and-physiological-factors-associated-with-stamina-in-dogs-exercising-in-high-ambient-temperatures
#9
Patrick J Robbins, Meghan T Ramos, Brian M Zanghi, Cynthia M Otto
This IACUC approved study was performed to evaluate the environmental, physiological, and hematological components that contribute to stamina following successive bouts of exercise that included searching (5-min), agility (5-min), and ball retrieve (<10-min). Regularly exercised dogs (N = 12) were evaluated on five separate occasions. The population consisted of eight males and four females ranging in age from 8 to 23 months, which included six Labrador retrievers, three German shepherds, and one each English springer spaniel, German wirehaired pointer, and Dutch shepherd...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28744688/intracranial-extradural-arachnoid-cyst-in-a-child
#10
Luyuan Li, Muhammad Ali, Arnold H Menezes, Brian J Dlouhy
INTRODUCTION: Arachnoid cysts are benign developmental anomalies of arachnoid membrane origin that can occur anywhere along the neuro-axis. They are believed to develop from the splitting or duplication of the arachnoid membrane by CSF that is trapped by a ball-valve mechanism. Intracranial arachnoid cysts have only been described as intradural lesions while spinal arachnoid cysts can be both intradural or extradural. CASE REPORT: After an extensive literature review, we report the first case of an intracranial, extradural arachnoid cyst in a 5-yearold girl...
December 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28709162/late-onset-sepsis-in-extremely-premature-infants-2000-2011
#11
Rachel G Greenberg, Sarah Kandefer, Barbara T Do, P Brian Smith, Barbara J Stoll, Edward F Bell, Waldemar A Carlo, Abbot R Laptook, Pablo J Sánchez, Seetha Shankaran, Krisa P Van Meurs, M Bethany Ball, Ellen C Hale, Nancy S Newman, Abhik Das, Rosemary D Higgins, C Michael Cotten
BACKGROUND: Late-onset sepsis (LOS) is an important cause of death and neurodevelopmental impairment in premature infants. The purpose of this study was to assess overall incidence of LOS, distribution of LOS-causative organisms and center variation in incidence of LOS for extremely premature infants over time. METHODS: In a retrospective analysis of infants 401-1000 g birth weight and 22-28 6/7 weeks of gestational age born at 12 National Institute of Child Health and Human Development Neonatal Research Network centers in the years 2000-2005 (era 1) or 2006-2011 (era 2) who survived >72 hours, we compared the incidence of LOS and pathogen distribution in the 2 eras using the χ test...
August 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28535955/fracture-resistance-of-molar-teeth-with-mesial-occlusal-distal-mod-restorations
#12
Herzl Chai, Brian R Lawn
OBJECTIVE: Filled MOD restorations show near-complete recovery of tooth strength relative to the newly prepared, unfilled state. The present study examines the underlying mechanics of this recovery by more closely quantifying the mode of splitting fracture from the cavity base. By understanding the role of specific cavity dimensions on fracture resistance, useful clinical guidelines concerning MOD morphologies are formulated. METHODS: A systematic in vitro study is made of the load-bearing capacity of filled and unfilled MOD cavities by axially loading extracted molar teeth with a hard metal ball...
July 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28505963/trunk-muscle-activation-levels-during-eight-stabilization-exercises-used-in-the-functional-kinetics-concept-a-controlled-laboratory-study
#13
Brian Horsak, Rüdiger Wunsch, Philipp Bernhart, Anna-Maria Gorgas, Romana Bichler, Kerstin Lampel
BACKGROUND: To ensure accurate implementation of stabilization exercises in rehabilitation, physical therapists need to understand the muscle activation patterns of prescribed exercise. OBJECTIVE: Compare muscle activity during eight trunk and lumbar spine stabilization exercises of the Functional Kinetics concept by Klein-Vogelbach. METHODS: A controlled laboratory study with a single-group repeated-measures design was utilized to analyze surface electromyographic intensities of 14 female and 6 male young healthy participants performing eight exercises...
2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28377414/diagnostic-distinction-of-malignant-melanoma-and-benign-nevi-by-a-gene-expression-signature-and-correlation-to-clinical-outcomes
#14
Jennifer S Ko, Balwir Matharoo-Ball, Steven D Billings, Brian J Thomson, Jean Y Tang, Kavita Y Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Z Kimbrell, Darl D Flake, M Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard J Wenstrup, Loren E Clarke
Background: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes.Methods: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature...
July 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28376827/lead-exposure-at-firing-ranges-a-review
#15
REVIEW
Mark A S Laidlaw, Gabriel Filippelli, Howard Mielke, Brian Gulson, Andrew S Ball
BACKGROUND: Lead (Pb) is a toxic substance with well-known, multiple, long-term, adverse health outcomes. Shooting guns at firing ranges is an occupational necessity for security personnel, police officers, members of the military, and increasingly a recreational activity by the public. In the United States alone, an estimated 16,000-18,000 firing ranges exist. Discharge of Pb dust and gases is a consequence of shooting guns. METHODS: The objectives of this study are to review the literature on blood lead levels (BLLs) and potential adverse health effects associated with the shooting population...
April 4, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28212099/high-density-high-radiance-mu-led-matrix-for-optogenetic-retinal-prostheses-and-planar-neural-stimulation
#16
Ahmed Soltan, Brian McGovern, Emmanuel Drakakis, Mark Neil, Pleun Maaskant, Mahbub Akhter, Jun Su Lee, Patrick Degenaar
Optical neuron stimulation arrays are important for both in-vitro biology and retinal prosthetic biomedical applications. Hence, in this work, we present an 8100 pixel high radiance photonic stimulator. The chip module vertically combines custom made gallium nitride μ LEDs with a CMOS application specific integrated circuit. This is designed with active pixels to ensure random access and to allow continuous illumination of all required pixels. The μLEDs have been assembled on the chip using a solder ball flip-chip bonding technique which has allowed for reliable and repeatable manufacture...
April 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28107113/the-relationship-between-pitching-mechanics-and-injury-a-review-of-current-concepts
#17
REVIEW
Peter N Chalmers, Markus A Wimmer, Nikhil N Verma, Brian J Cole, Anthony A Romeo, Gregory L Cvetanovich, Michael L Pearl
CONTEXT: The overhand pitch is one of the fastest known human motions and places enormous forces and torques on the upper extremity. Shoulder and elbow pain and injury are common in high-level pitchers. A large body of research has been conducted to understand the pitching motion. EVIDENCE ACQUISITION: A comprehensive review of the literature was performed to gain a full understanding of all currently available biomechanical and clinical evidence surrounding pitching motion analysis...
May 2017: Sports Health
https://www.readbyqxmd.com/read/28104707/improving-care-standards-for-patients-with-spinal-trauma-combining-a-modified-e-delphi-process-and-stakeholder-interviews-a-study-protocol
#18
Lisa N Sharwood, Ralph Stanford, James W Middleton, Brian Burns, Anthony Joseph, Oliver Flower, Oran Rigby, Jonathon Ball, Shelly Dhaliwal
INTRODUCTION: Around 300 people sustain a new traumatic spinal cord injury (TSCI) in Australia each year; a relatively low incidence injury with extremely high long-term associated costs. Care standards are inconsistent nationally, lacking in consensus across important components of care such as prehospital spinal immobilisation, timing of surgery and timeliness of transfer to specialist services. This study aims to develop 'expertly defined' and agreed standards of care across the majority of disciplines involved for these patients...
January 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/27990119/oral-administration-of-sitagliptin-activates-creb-and-is-neuroprotective-in-murine-model-of-brain-trauma
#19
Brian DellaValle, Gitte S Brix, Birgitte Brock, Michael Gejl, Jørgen Rungby, Agnete Larsen
Introduction: Traumatic brain injury is a major cause of mortality and morbidity. We have previously shown that the injectable glucagon-like peptide-1 (GLP-1) analog, liraglutide, significantly improved the outcome in mice after severe traumatic brain injury (TBI). In this study we are interested in the effects of oral treatment of a different class of GLP-1 based therapy, dipeptidyl peptidase IV (DPP-IV) inhibition on mice after TBI. DPP-IV inhibitors reduce the degradation of endogenous GLP-1 and extend circulation of this protective peptide in the bloodstream...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27935447/lateral-mass-screw-stimulation-thresholds-in-posterior-cervical-instrumentation-surgery-a-predictor-of-medial-deviation
#20
Bayard Wilson, Erik Curtis, Brian Hirshman, Ahmet Oygar, Karen Chen, Brandon C Gabel, Florin Vaida, David W Allison, Joseph D Ciacci
OBJECTIVE Normative data exists for stimulus-evoked pedicle screw electromyography (EMG) current thresholds in the lumbar spine, and is routinely referenced during spine surgeries to detect a screw breach, prevent injury of neural elements, and ensure the most biomechanically sound instrumentation construct. To date, similar normative data for cervical lateral mass screws is limited, thus the utility of lateral mass screw testing remains unclear. To address this disparity, in this study the authors describe cumulative lateral mass screw stimulation threshold data in patients undergoing posterior cervical instrumentation with lateral mass screws...
March 2017: Journal of Neurosurgery. Spine
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