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https://www.readbyqxmd.com/read/28535955/fracture-resistance-of-molar-teeth-with-mesial-occlusal-distal-mod-restorations
#1
Herzl Chai, Brian R Lawn
OBJECTIVE: Filled MOD restorations show near-complete recovery of tooth strength relative to the newly prepared, unfilled state. The present study examines the underlying mechanics of this recovery by more closely quantifying the mode of splitting fracture from the cavity base. By understanding the role of specific cavity dimensions on fracture resistance, useful clinical guidelines concerning MOD morphologies are formulated. METHODS: A systematic in vitro study is made of the load-bearing capacity of filled and unfilled MOD cavities by axially loading extracted molar teeth with a hard metal ball...
July 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28505963/trunk-muscle-activation-levels-during-eight-stabilization-exercises-used-in-the-functional-kinetics-concept-a-controlled-laboratory-study
#2
Brian Horsak, Rüdiger Wunsch, Philipp Bernhart, Anna-Maria Gorgas, Romana Bichler, Kerstin Lampel
BACKGROUND: To ensure accurate implementation of stabilization exercises in rehabilitation, physical therapists need to understand the muscle activation patterns of prescribed exercise. OBJECTIVE: Compare muscle activity during eight trunk and lumbar spine stabilization exercises of the Functional Kinetics concept by Klein-Vogelbach. METHODS: A controlled laboratory study with a single-group repeated-measures design was utilized to analyze surface electromyographic intensities of 14 female and 6 male young healthy participants performing eight exercises...
2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28377414/diagnostic-distinction-of-malignant-melanoma-and-benign-nevi-by-a-gene-expression-signature-and-correlation-to-clinical-outcomes
#3
Jennifer Ko, Balwir Matharoo-Ball, Steven D Billings, Brian J Thomson, Jean Y Tang, Kavita Y Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Kimbrell, Darl D Flake, M Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard J Wenstrup, Loren E Clarke
BACKGROUND: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes. METHODS: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature...
April 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28376827/lead-exposure-at-firing-ranges-a-review
#4
REVIEW
Mark A S Laidlaw, Gabriel Filippelli, Howard Mielke, Brian Gulson, Andrew S Ball
BACKGROUND: Lead (Pb) is a toxic substance with well-known, multiple, long-term, adverse health outcomes. Shooting guns at firing ranges is an occupational necessity for security personnel, police officers, members of the military, and increasingly a recreational activity by the public. In the United States alone, an estimated 16,000-18,000 firing ranges exist. Discharge of Pb dust and gases is a consequence of shooting guns. METHODS: The objectives of this study are to review the literature on blood lead levels (BLLs) and potential adverse health effects associated with the shooting population...
April 4, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28212099/high-density-high-radiance-mu-led-matrix-for-optogenetic-retinal-prostheses-and-planar-neural-stimulation
#5
Ahmed Soltan, Brian McGovern, Emmanuel Drakakis, Mark Neil, Pleun Maaskant, Mahbub Akhter, Jun Su Lee, Patrick Degenaar
Optical neuron stimulation arrays are important for both in-vitro biology and retinal prosthetic biomedical applications. Hence, in this work, we present an 8100 pixel high radiance photonic stimulator. The chip module vertically combines custom made gallium nitride μ LEDs with a CMOS application specific integrated circuit. This is designed with active pixels to ensure random access and to allow continuous illumination of all required pixels. The μLEDs have been assembled on the chip using a solder ball flip-chip bonding technique which has allowed for reliable and repeatable manufacture...
April 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28107113/the-relationship-between-pitching-mechanics-and-injury-a-review-of-current-concepts
#6
Peter N Chalmers, Markus A Wimmer, Nikhil N Verma, Brian J Cole, Anthony A Romeo, Gregory L Cvetanovich, Michael L Pearl, Peter N Chalmers, Markus A Wimmer, Nikhil N Verma, Brian J Cole, Anthony A Romeo, Gregory L Cvetanovich, Michael L Pearl
CONTEXT: The overhand pitch is one of the fastest known human motions and places enormous forces and torques on the upper extremity. Shoulder and elbow pain and injury are common in high-level pitchers. A large body of research has been conducted to understand the pitching motion. EVIDENCE ACQUISITION: A comprehensive review of the literature was performed to gain a full understanding of all currently available biomechanical and clinical evidence surrounding pitching motion analysis...
May 2017: Sports Health
https://www.readbyqxmd.com/read/28104707/improving-care-standards-for-patients-with-spinal-trauma-combining-a-modified-e-delphi-process-and-stakeholder-interviews-a-study-protocol
#7
Lisa N Sharwood, Ralph Stanford, James W Middleton, Brian Burns, Anthony Joseph, Oliver Flower, Oran Rigby, Jonathon Ball, Shelly Dhaliwal
INTRODUCTION: Around 300 people sustain a new traumatic spinal cord injury (TSCI) in Australia each year; a relatively low incidence injury with extremely high long-term associated costs. Care standards are inconsistent nationally, lacking in consensus across important components of care such as prehospital spinal immobilisation, timing of surgery and timeliness of transfer to specialist services. This study aims to develop 'expertly defined' and agreed standards of care across the majority of disciplines involved for these patients...
January 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/27990119/oral-administration-of-sitagliptin-activates-creb-and-is-neuroprotective-in-murine-model-of-brain-trauma
#8
Brian DellaValle, Gitte S Brix, Birgitte Brock, Michael Gejl, Jørgen Rungby, Agnete Larsen
Introduction: Traumatic brain injury is a major cause of mortality and morbidity. We have previously shown that the injectable glucagon-like peptide-1 (GLP-1) analog, liraglutide, significantly improved the outcome in mice after severe traumatic brain injury (TBI). In this study we are interested in the effects of oral treatment of a different class of GLP-1 based therapy, dipeptidyl peptidase IV (DPP-IV) inhibition on mice after TBI. DPP-IV inhibitors reduce the degradation of endogenous GLP-1 and extend circulation of this protective peptide in the bloodstream...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27935447/lateral-mass-screw-stimulation-thresholds-in-posterior-cervical-instrumentation-surgery-a-predictor-of-medial-deviation
#9
Bayard Wilson, Erik Curtis, Brian Hirshman, Ahmet Oygar, Karen Chen, Brandon C Gabel, Florin Vaida, David W Allison, Joseph D Ciacci
OBJECTIVE Normative data exists for stimulus-evoked pedicle screw electromyography (EMG) current thresholds in the lumbar spine, and is routinely referenced during spine surgeries to detect a screw breach, prevent injury of neural elements, and ensure the most biomechanically sound instrumentation construct. To date, similar normative data for cervical lateral mass screws is limited, thus the utility of lateral mass screw testing remains unclear. To address this disparity, in this study the authors describe cumulative lateral mass screw stimulation threshold data in patients undergoing posterior cervical instrumentation with lateral mass screws...
March 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27930445/motion-and-muscle-activity-are-affected-by-instability-location-during-a-squat-exercise
#10
Brian C Nairn, Chad A Sutherland, Janessa D M Drake
Nairn, BC, Sutherland, CA, and Drake, JDM. Motion and muscle activity are affected by instability location during a squat exercise. J Strength Cond Res 31(3): 677-685, 2017-Squat exercise training using instability devices has become increasingly popular for a multitude of reasons. Many devices generate instability at the feet and provide a bottom-up perturbation; however, the effect of a top-down instability device during a squat remains unclear. To induce instability at the upper body, a water-filled cylinder called the Attitube was used...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27844188/correlation-and-predictive-value-of-aortic-root-calcification-markers-with-coronary-artery-calcification-and-obstructive-coronary-artery-disease
#11
COMPARATIVE STUDY
Christian Tesche, Carlo N De Cecco, Andrew Stubenrauch, Brian E Jacobs, Akos Varga-Szemes, Sheldon E Litwin, B Devon Ball, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R Bayer, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
OBJECTIVE: To evaluate the correlation between aortic root calcification (ARC) markers and coronary artery calcification (CAC) derived from coronary artery calcium scoring (CACS) and their ability to predict obstructive coronary artery disease (CAD). METHODS: We retrospectively analyzed 189 patients (47% male, age 60.3 ± 11.1 years) with an intermediate probability of CAD who underwent clinically indicated CACS and coronary CT angiography (CCTA). ARC markers [aortic root calcium score (ARCS) and volume (ARCV)] were calculated and compared to CAC markers: coronary artery calcium score (CACS), volume (CACV), and mass (CACM)...
February 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/27618904/risk-assessment-for-children-exposed-to-beach-sands-impacted-by-oil-spill-chemicals
#12
Jennifer C Black, Jennifer N Welday, Brian Buckley, Alesia Ferguson, Patrick L Gurian, Kristina D Mena, Ill Yang, Elizabeth McCandlish, Helena M Solo-Gabriele
Due to changes in the drilling industry, oil spills are impacting large expanses of coastlines, thereby increasing the potential for people to come in contact with oil spill chemicals. The objective of this manuscript was to evaluate the health risk to children who potentially contact beach sands impacted by oil spill chemicals from the Deepwater Horizon disaster. To identify chemicals of concern, the U.S. Environmental Protection Agency's (EPA's) monitoring data collected during and immediately after the spill were evaluated...
August 27, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27544098/a-cmos-millimeter-wave-transceiver-embedded-in-a-semi-confocal-fabry-perot-cavity-for-molecular-spectroscopy
#13
Brian J Drouin, Adrian Tang, Erich Schlecht, Emily Brageot, Q Jane Gu, Y Ye, R Shu, Mau-Chung Frank Chang, Y Kim
The extension of radio frequency complementary metal oxide semiconductor (CMOS) circuitry into millimeter wavelengths promises the extension of spectroscopic techniques in compact, power efficient systems. We are now beginning to use CMOS millimeter devices for low-mass, low-power instrumentation capable of remote or in situ detection of gas composition during space missions. We have chosen to develop a Flygare-Balle type spectrometer, with a semi-confocal Fabry-Perot cavity to amplify the pump power of a mm-wavelength CMOS transmitter that is directly coupled to the planar mirror of the cavity...
August 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27299809/phase-3-trials-of-ixekizumab-in-moderate-to-severe-plaque-psoriasis
#14
RANDOMIZED CONTROLLED TRIAL
Kenneth B Gordon, Andrew Blauvelt, Kim A Papp, Richard G Langley, Thomas Luger, Mamitaro Ohtsuki, Kristian Reich, David Amato, Susan G Ball, Daniel K Braun, Gregory S Cameron, Janelle Erickson, Robert J Konrad, Talia M Muram, Brian J Nickoloff, Olawale O Osuntokun, Roberta J Secrest, Fangyi Zhao, Lotus Mallbris, Craig L Leonardi
BACKGROUND: Two phase 3 trials (UNCOVER-2 and UNCOVER-3) showed that at 12 weeks of treatment, ixekizumab, a monoclonal antibody against interleukin-17A, was superior to placebo and etanercept in the treatment of moderate-to-severe psoriasis. We report the 60-week data from the UNCOVER-2 and UNCOVER-3 trials, as well as 12-week and 60-week data from a third phase 3 trial, UNCOVER-1. METHODS: We randomly assigned 1296 patients in the UNCOVER-1 trial, 1224 patients in the UNCOVER-2 trial, and 1346 patients in the UNCOVER-3 trial to receive subcutaneous injections of placebo (placebo group), 80 mg of ixekizumab every 2 weeks after a starting dose of 160 mg (2-wk dosing group), or 80 mg of ixekizumab every 4 weeks after a starting dose of 160 mg (4-wk dosing group)...
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27225775/optogenetic-interrogation-of-functional-synapse-formation-by-corticospinal-tract-axons-in-the-injured-spinal-cord
#15
Naveen Jayaprakash, Zimei Wang, Brian Hoeynck, Nicholas Krueger, Audra Kramer, Eric Balle, Daniel S Wheeler, Robert A Wheeler, Murray G Blackmore
UNLABELLED: To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor Sox11 increases axon growth by corticospinal tract (CST) neurons after spinal injury. However, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons are able to form functional synapses...
May 25, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27215774/does-load-uncertainty-affect-adaptation-to-catch-training
#16
William P Berg, Brian J Richards, Aaron M Hannigan, Kelsey L Biller, Michael R Hughes
Catching relies on anticipatory and compensatory control processes. Load uncertainty increases anticipatory and compensatory neuromotor effort in catching. This experiment tested the effect of load uncertainty in plyometric catch/throw training on elbow flexion reaction time (RT), movement time (MT) and peak torque, as well as the distribution of anticipatory and compensatory neuromotor effort in catching. We expected load uncertainty training to be superior to traditional training for improving elbow flexion MT and peak torque, as well as for reallocating neuromotor effort from compensatory to anticipatory control in catching...
September 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27132773/epidemiologic-comparison-of-pitching-mechanics-pitch-type-and-pitch-counts-among-healthy-pitchers-at-various-levels-of-youth-competition
#17
Andrew J Riff, Peter N Chalmers, Terrance Sgroi, Matthew Lesniak, Eli T Sayegh, Nikhil N Verma, Brian J Cole, Anthony A Romeo
PURPOSE: To determine differences among healthy pitchers at various levels of competition regarding pitching history, pitching mechanics, and prevalence of breaking pitches. METHODS: Demographic, anthropometric, pitching history, and kinematic data were collected on healthy youth pitchers using dual orthogonal high-speed video analysis. Players were grouped by maturity level (9 to 12 [prepubescent], 13 to 15 [pubescent], 16 to 17 [mature], and 18 to 22 years [adult])...
August 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27044125/fall-risk-associated-with-continuous-peripheral-nerve-blocks-following-knee-and-hip-arthroplasty
#18
Daphna M Finn, Rishi R Agarwal, Brian M Ilfeld, Sarah J Madison, Scott T Ball, Eliza J Ferguson, Anya C Morgan, Beverly A Morris
Combined scientific advances in pharmaceutical agents, perineural blocks, and pump delivery capabilities such as those used with continuous peripheral nerve blocks have demonstrated advantages in pain management for patients undergoing joint arthroplasty. This report documents the incidence of falls increased after the implementation of a continuous peripheral nerve block program for patients undergoing knee and hip arthroplasty in an academic medical center.
January 2016: Medsurg Nursing: Official Journal of the Academy of Medical-Surgical Nurses
https://www.readbyqxmd.com/read/26983459/fastball-pitch-velocity-helps-predict-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers
#19
Peter N Chalmers, Brandon J Erickson, Brian Ball, Anthony A Romeo, Nikhil N Verma
BACKGROUND: Ulnar collateral ligament injury and its subsequent surgical reconstruction are some of the most common issues among Major League Baseball (MLB) players. PURPOSE/HYPOTHESIS: The purpose of this study was to determine factors predictive of ulnar collateral ligament reconstruction (UCLR) among MLB pitchers. The hypothesis was that pitchers who underwent UCLR would have higher preinjury peak fastball pitch velocity. STUDY DESIGN: Case-control study; Level of evidence, 3...
August 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26967229/microbes-and-alzheimer-s-disease
#20
REVIEW
Ruth F Itzhaki, Richard Lathe, Brian J Balin, Melvyn J Ball, Elaine L Bearer, Heiko Braak, Maria J Bullido, Chris Carter, Mario Clerici, S Louise Cosby, Kelly Del Tredici, Hugh Field, Tamas Fulop, Claudio Grassi, W Sue T Griffin, Jürgen Haas, Alan P Hudson, Angela R Kamer, Douglas B Kell, Federico Licastro, Luc Letenneur, Hugo Lövheim, Roberta Mancuso, Judith Miklossy, Carola Otth, Anna Teresa Palamara, George Perry, Christopher Preston, Etheresia Pretorius, Timo Strandberg, Naji Tabet, Simon D Taylor-Robinson, Judith A Whittum-Hudson
No abstract text is available yet for this article.
2016: Journal of Alzheimer's Disease: JAD
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