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Brian Ball

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https://www.readbyqxmd.com/read/27990119/oral-administration-of-sitagliptin-activates-creb-and-is-neuroprotective-in-murine-model-of-brain-trauma
#1
Brian DellaValle, Gitte S Brix, Birgitte Brock, Michael Gejl, Jørgen Rungby, Agnete Larsen
Introduction: Traumatic brain injury is a major cause of mortality and morbidity. We have previously shown that the injectable glucagon-like peptide-1 (GLP-1) analog, liraglutide, significantly improved the outcome in mice after severe traumatic brain injury (TBI). In this study we are interested in the effects of oral treatment of a different class of GLP-1 based therapy, dipeptidyl peptidase IV (DPP-IV) inhibition on mice after TBI. DPP-IV inhibitors reduce the degradation of endogenous GLP-1 and extend circulation of this protective peptide in the bloodstream...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27935447/lateral-mass-screw-stimulation-thresholds-in-posterior-cervical-instrumentation-surgery-a-predictor-of-medial-deviation
#2
Bayard Wilson, Erik Curtis, Brian Hirshman, Ahmet Oygar, Karen Chen, Brandon C Gabel, Florin Vaida, David W Allison, Joseph D Ciacci
OBJECTIVE Normative data exists for stimulus-evoked pedicle screw electromyography (EMG) current thresholds in the lumbar spine, and is routinely referenced during spine surgeries to detect a screw breach, prevent injury of neural elements, and ensure the most biomechanically sound instrumentation construct. To date, similar normative data for cervical lateral mass screws is limited, thus the utility of lateral mass screw testing remains unclear. To address this disparity, in this study the authors describe cumulative lateral mass screw stimulation threshold data in patients undergoing posterior cervical instrumentation with lateral mass screws...
December 9, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27930445/motion-and-muscle-activity-are-affected-by-instability-location-during-a-squat-exercise
#3
Brian C Nairn, Chad A Sutherland, Janessa D M Drake
Squat exercise training using instability devices have become increasingly popular for a multitude of reasons. Many devices generate instability at the feet and provide a bottom-up perturbation; however, the effect of a top-down instability device during a squat remains unclear. In order to induce instability at the upper body, a water-filled cylinder called the Attitube® was used. This study analyzed the effects of instability location (top-down, bottom-up, no instability) during a squat exercise in terms of kinematics and muscle activation...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27844188/correlation-and-predictive-value-of-aortic-root-calcification-markers-with-coronary-artery-calcification-and-obstructive-coronary-artery-disease
#4
Christian Tesche, Carlo N De Cecco, Andrew Stubenrauch, Brian E Jacobs, Akos Varga-Szemes, Sheldon E Litwin, B Devon Ball, Moritz Baquet, David Jochheim, Ullrich Ebersberger, Richard R Bayer, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
OBJECTIVE: To evaluate the correlation between aortic root calcification (ARC) markers and coronary artery calcification (CAC) derived from coronary artery calcium scoring (CACS) and their ability to predict obstructive coronary artery disease (CAD). METHODS: We retrospectively analyzed 189 patients (47% male, age 60.3 ± 11.1 years) with an intermediate probability of CAD who underwent clinically indicated CACS and coronary CT angiography (CCTA). ARC markers [aortic root calcium score (ARCS) and volume (ARCV)] were calculated and compared to CAC markers: coronary artery calcium score (CACS), volume (CACV), and mass (CACM)...
November 14, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27618904/risk-assessment-for-children-exposed-to-beach-sands-impacted-by-oil-spill-chemicals
#5
Jennifer C Black, Jennifer N Welday, Brian Buckley, Alesia Ferguson, Patrick L Gurian, Kristina D Mena, Ill Yang, Elizabeth McCandlish, Helena M Solo-Gabriele
Due to changes in the drilling industry, oil spills are impacting large expanses of coastlines, thereby increasing the potential for people to come in contact with oil spill chemicals. The objective of this manuscript was to evaluate the health risk to children who potentially contact beach sands impacted by oil spill chemicals from the Deepwater Horizon disaster. To identify chemicals of concern, the U.S. Environmental Protection Agency's (EPA's) monitoring data collected during and immediately after the spill were evaluated...
August 27, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27544098/a-cmos-millimeter-wave-transceiver-embedded-in-a-semi-confocal-fabry-perot-cavity-for-molecular-spectroscopy
#6
Brian J Drouin, Adrian Tang, Erich Schlecht, Emily Brageot, Q Jane Gu, Y Ye, R Shu, Mau-Chung Frank Chang, Y Kim
The extension of radio frequency complementary metal oxide semiconductor (CMOS) circuitry into millimeter wavelengths promises the extension of spectroscopic techniques in compact, power efficient systems. We are now beginning to use CMOS millimeter devices for low-mass, low-power instrumentation capable of remote or in situ detection of gas composition during space missions. We have chosen to develop a Flygare-Balle type spectrometer, with a semi-confocal Fabry-Perot cavity to amplify the pump power of a mm-wavelength CMOS transmitter that is directly coupled to the planar mirror of the cavity...
August 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27299809/phase-3-trials-of-ixekizumab-in-moderate-to-severe-plaque-psoriasis
#7
RANDOMIZED CONTROLLED TRIAL
Kenneth B Gordon, Andrew Blauvelt, Kim A Papp, Richard G Langley, Thomas Luger, Mamitaro Ohtsuki, Kristian Reich, David Amato, Susan G Ball, Daniel K Braun, Gregory S Cameron, Janelle Erickson, Robert J Konrad, Talia M Muram, Brian J Nickoloff, Olawale O Osuntokun, Roberta J Secrest, Fangyi Zhao, Lotus Mallbris, Craig L Leonardi
BACKGROUND: Two phase 3 trials (UNCOVER-2 and UNCOVER-3) showed that at 12 weeks of treatment, ixekizumab, a monoclonal antibody against interleukin-17A, was superior to placebo and etanercept in the treatment of moderate-to-severe psoriasis. We report the 60-week data from the UNCOVER-2 and UNCOVER-3 trials, as well as 12-week and 60-week data from a third phase 3 trial, UNCOVER-1. METHODS: We randomly assigned 1296 patients in the UNCOVER-1 trial, 1224 patients in the UNCOVER-2 trial, and 1346 patients in the UNCOVER-3 trial to receive subcutaneous injections of placebo (placebo group), 80 mg of ixekizumab every 2 weeks after a starting dose of 160 mg (2-wk dosing group), or 80 mg of ixekizumab every 4 weeks after a starting dose of 160 mg (4-wk dosing group)...
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27225775/optogenetic-interrogation-of-functional-synapse-formation-by-corticospinal-tract-axons-in-the-injured-spinal-cord
#8
Naveen Jayaprakash, Zimei Wang, Brian Hoeynck, Nicholas Krueger, Audra Kramer, Eric Balle, Daniel S Wheeler, Robert A Wheeler, Murray G Blackmore
UNLABELLED: To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor Sox11 increases axon growth by corticospinal tract (CST) neurons after spinal injury. However, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons are able to form functional synapses...
May 25, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27215774/does-load-uncertainty-affect-adaptation-to-catch-training
#9
William P Berg, Brian J Richards, Aaron M Hannigan, Kelsey L Biller, Michael R Hughes
Catching relies on anticipatory and compensatory control processes. Load uncertainty increases anticipatory and compensatory neuromotor effort in catching. This experiment tested the effect of load uncertainty in plyometric catch/throw training on elbow flexion reaction time (RT), movement time (MT) and peak torque, as well as the distribution of anticipatory and compensatory neuromotor effort in catching. We expected load uncertainty training to be superior to traditional training for improving elbow flexion MT and peak torque, as well as for reallocating neuromotor effort from compensatory to anticipatory control in catching...
September 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27132773/epidemiologic-comparison-of-pitching-mechanics-pitch-type-and-pitch-counts-among-healthy-pitchers-at-various-levels-of-youth-competition
#10
Andrew J Riff, Peter N Chalmers, Terrance Sgroi, Matthew Lesniak, Eli T Sayegh, Nikhil N Verma, Brian J Cole, Anthony A Romeo
PURPOSE: To determine differences among healthy pitchers at various levels of competition regarding pitching history, pitching mechanics, and prevalence of breaking pitches. METHODS: Demographic, anthropometric, pitching history, and kinematic data were collected on healthy youth pitchers using dual orthogonal high-speed video analysis. Players were grouped by maturity level (9 to 12 [prepubescent], 13 to 15 [pubescent], 16 to 17 [mature], and 18 to 22 years [adult])...
August 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27044125/fall-risk-associated-with-continuous-peripheral-nerve-blocks-following-knee-and-hip-arthroplasty
#11
Daphna M Finn, Rishi R Agarwal, Brian M Ilfeld, Sarah J Madison, Scott T Ball, Eliza J Ferguson, Anya C Morgan, Beverly A Morris
Combined scientific advances in pharmaceutical agents, perineural blocks, and pump delivery capabilities such as those used with continuous peripheral nerve blocks have demonstrated advantages in pain management for patients undergoing joint arthroplasty. This report documents the incidence of falls increased after the implementation of a continuous peripheral nerve block program for patients undergoing knee and hip arthroplasty in an academic medical center.
January 2016: Medsurg Nursing: Official Journal of the Academy of Medical-Surgical Nurses
https://www.readbyqxmd.com/read/26983459/fastball-pitch-velocity-helps-predict-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers
#12
Peter N Chalmers, Brandon J Erickson, Brian Ball, Anthony A Romeo, Nikhil N Verma
BACKGROUND: Ulnar collateral ligament injury and its subsequent surgical reconstruction are some of the most common issues among Major League Baseball (MLB) players. PURPOSE/HYPOTHESIS: The purpose of this study was to determine factors predictive of ulnar collateral ligament reconstruction (UCLR) among MLB pitchers. The hypothesis was that pitchers who underwent UCLR would have higher preinjury peak fastball pitch velocity. STUDY DESIGN: Case-control study; Level of evidence, 3...
August 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26967229/microbes-and-alzheimer-s-disease
#13
REVIEW
Ruth F Itzhaki, Richard Lathe, Brian J Balin, Melvyn J Ball, Elaine L Bearer, Heiko Braak, Maria J Bullido, Chris Carter, Mario Clerici, S Louise Cosby, Kelly Del Tredici, Hugh Field, Tamas Fulop, Claudio Grassi, W Sue T Griffin, Jürgen Haas, Alan P Hudson, Angela R Kamer, Douglas B Kell, Federico Licastro, Luc Letenneur, Hugo Lövheim, Roberta Mancuso, Judith Miklossy, Carola Otth, Anna Teresa Palamara, George Perry, Christopher Preston, Etheresia Pretorius, Timo Strandberg, Naji Tabet, Simon D Taylor-Robinson, Judith A Whittum-Hudson
No abstract text is available yet for this article.
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26900525/a-model-for-geometry-dependent-errors-in-length-artifacts
#14
Daniel Sawyer, Brian Parry, Steven Phillips, Chris Blackburn, Bala Muralikrishnan
We present a detailed model of dimensional changes in long length artifacts, such as step gauges and ball bars, due to bending under gravity. The comprehensive model is based on evaluation of the gauge points relative to the neutral bending surface. It yields the errors observed when the gauge points are located off the neutral bending surface of a bar or rod but also reveals the significant error associated with out-of-straightness of a bar or rod even if the gauge points are located in the neutral bending surface...
2012: Journal of Research of the National Institute of Standards and Technology
https://www.readbyqxmd.com/read/26871091/structural-inference-for-uncertain-networks
#15
Travis Martin, Brian Ball, M E J Newman
In the study of networked systems such as biological, technological, and social networks the available data are often uncertain. Rather than knowing the structure of a network exactly, we know the connections between nodes only with a certain probability. In this paper we develop methods for the analysis of such uncertain data, focusing particularly on the problem of community detection. We give a principled maximum-likelihood method for inferring community structure and demonstrate how the results can be used to make improved estimates of the true structure of the network...
January 2016: Physical Review. E
https://www.readbyqxmd.com/read/26842502/supporting-physical-activity-in-the-childcare-environment-space-rationale-and-study-protocol-for-a-cluster-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Patricia Tucker, Shauna M Burke, Anca Gaston, Jennifer D Irwin, Andrew M Johnson, Brian W Timmons, Leigh M Vanderloo, Molly Driediger
BACKGROUND: Young children are prone to low levels of physical activity in childcare. Researchers have identified that preschoolers tend to be more active outdoors than indoors, with higher activity levels occurring during the first 10 minutes of outdoor playtime. Additionally, interventions incorporating either staff training or the inclusion of play equipment have been effective at increasing children's activity in this setting. As such, the overarching objective of the Supporting Physical Activity in the Childcare Environment (SPACE) intervention is to improve the physical activity levels of preschoolers during childcare hours, utilizing a combination of the above components...
2016: BMC Public Health
https://www.readbyqxmd.com/read/26759604/biological-lignocellulose-solubilization-comparative-evaluation-of-biocatalysts-and-enhancement-via-cotreatment
#17
Julie M D Paye, Anna Guseva, Sarah K Hammer, Erica Gjersing, Mark F Davis, Brian H Davison, Jessica Olstad, Bryon S Donohoe, Thanh Yen Nguyen, Charles E Wyman, Sivakumar Pattathil, Michael G Hahn, Lee R Lynd
BACKGROUND: Feedstock recalcitrance is the most important barrier impeding cost-effective production of cellulosic biofuels. Pioneer commercial cellulosic ethanol facilities employ thermochemical pretreatment and addition of fungal cellulase, reflecting the main research emphasis in the field. However, it has been suggested that it may be possible to process cellulosic biomass without thermochemical pretreatment using thermophilic, cellulolytic bacteria. To further explore this idea, we examine the ability of various biocatalysts to solubilize autoclaved but otherwise unpretreated cellulosic biomass under controlled but not industrial conditions...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/26727532/alcohol-mixed-with-energy-drink-use-as-an-event-level-predictor-of-physical-and-verbal-aggression-in-bar-conflicts
#18
Kathleen E Miller, Brian M Quigley, Rebecca K Eliseo-Arras, Natalie J Ball
BACKGROUND: Young adult use of alcohol mixed with caffeinated energy drinks (AmEDs) has been globally linked with increased odds of interpersonal aggression, compared with the use of alcohol alone. However, no prior research has linked these behaviors at the event level in bar drinking situations. The present study assessed whether AmED use is associated with the perpetration of verbal and physical aggression in bar conflicts at the event level. METHODS: In Fall 2014, a community sample of 175 young adult AmED users (55% female) completed a web survey describing a recent conflict experienced while drinking in a bar...
January 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/26577976/laryngeal-fracture-caused-by-a-lacrosse-ball
#19
Aaron Trinidade, Muhammad Shakeel, Brian Stickle, Kim W Ah-See
Neck injuries in lacrosse are rare and mostly involve the musculoskeletal system. The lacrosse ball is a solid rubber ball of approximately 20 cm in diameter and the fastest shot recorded in professional lacrosse is over 100 mph. Despite wearing full protection, the neck remains prone to blunt trauma by this ball. A 23-year man sustained a direct blow to his left neck by a lacrosse ball during play, resulting in immediate aphonia and stridor. CT scan confirmed a left thyroid lamina fracture. The patient was treated conservatively and his airway was monitored for 24 hours...
November 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/26540475/effect-of-ultraviolet-exposure-on-impact-resistance-of-ophthalmic-lenses
#20
B Ralph Chou, Stephen J Dain, Brian B Cheng
PURPOSE: To investigate the effect of ultraviolet radiation (UVR) on the impact resistance of organic ophthalmic lens materials. METHODS: Plano power CR39, Phoenix, Trilogy, and polycarbonate lenses with various scratch-resistant (SR) and/or antireflection (AR) coatings were obtained in batches of 40 units. All lenses had a nominal thickness of 2 mm. Half of each batch was conditioned following the European Standard EN 168 protocol for the test of resistance to UVR (exposed group)...
December 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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