Katrina L Randall, Inge E A Flesch, Yan Mei, Lisa A Miosge, Racheal Aye, Zhijia Yu, Heather Domaschenz, Natasha A Hollett, Tiffany A Russell, Tijana Stefanovic, Yik Chun Wong, Sandali Seneviratne, Fiona Ballard, Raquel Hernandez Gallardo, Sarah N Croft, Christopher C Goodnow, Edward M Bertram, Anselm Enders, David C Tscharke
The expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defence against infectious diseases. However, analysis of these in patients is complicated by their treatments and co-morbid infections requiring the use of mouse models for detailed investigations. Here we develop a mouse model of DOCK2 immunodeficiency and demonstrate that these mice have delayed clearance of herpes simplex virus type 1 (HSV-1) infections. We also uncovered a critical, cell intrinsic role of DOCK2 in the priming of anti-viral CD8+ T cells and in particular their initial expansion, despite apparently normal early activation of these cells...
February 15, 2024: Journal of Infectious Diseases