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Timothy Kwang Yong Tay, Aye Aye Thike, Nirmala Pathmanathan, Ana Richelia Jara-Lazaro, Jabed Iqbal, Adeline Shi Hui Sng, Heng Seow Ye, Jeffrey Chun Tatt Lim, Valerie Cui Yun Koh, Jane Sie Yong Tan, Joe Poh Sheng Yeong, Zi Long Chow, Hui Hua Li, Chee Leong Cheng, Puay Hoon Tan
Background: Ki67 positivity in invasive breast cancers has an inverse correlation with survival outcomes and serves as an immunohistochemical surrogate for molecular subtyping of breast cancer, particularly ER positive breast cancer. The optimal threshold of Ki67 in both settings, however, remains elusive. We use computer assisted image analysis (CAIA) to determine the optimal threshold for Ki67 in predicting survival outcomes and differentiating luminal B from luminal A breast cancers...
February 20, 2018: Oncotarget
Sanjay Kalra, Silver Bahendeka, Rakesh Sahay, Sujoy Ghosh, Fariduddin Md, Abbas Orabi, Kaushik Ramaiya, Sameer Al Shammari, Dina Shrestha, Khalid Shaikh, Sachitha Abhayaratna, Pradeep K Shrestha, Aravinthan Mahalingam, Mazen Askheta, Aly Ahmed A Rahim, Fatimah Eliana, Hari K Shrestha, Sandeep Chaudhary, Nancy Ngugi, Jean Claude Mbanya, Than Than Aye, Tint Swe Latt, Zhanay A Akanov, Abbas Raza Syed, Nikhil Tandon, A G Unnikrishnan, S V Madhu, Ali Jawa, Subhankar Chowdhury, Sarita Bajaj, Ashok Kumar Das
For decades, sulfonylureas (SUs) have been important drugs in the antidiabetic therapeutic armamentarium. They have been used as monotherapy as well as combination therapy. Focus on newer drugs and concerns about the risk of severe hypoglycemia and weight gain with some SUs have led to discussion on their safety and utility. It has to be borne in mind that the adverse events associated with SUs should not be ascribed to the whole class, as many modern SUs, such as glimepiride and gliclazide modified release, are associated with better safety profiles...
January 2018: Indian Journal of Endocrinology and Metabolism
Yi Zhao, Marcus J C Long, Yiran Wang, Sheng Zhang, Yimon Aye
Posttranslational modifications (PTMs) are the lingua franca of cellular communication. Most PTMs are enzyme-orchestrated. However, the reemergence of electrophilic drugs has ushered mining of unconventional/non-enzyme-catalyzed electrophile-signaling pathways. Despite the latest impetus toward harnessing kinetically and functionally privileged cysteines for electrophilic drug design, identifying these sensors remains challenging. Herein, we designed "G-REX"-a technique that allows controlled release of reactive electrophiles in vivo...
February 28, 2018: ACS Central Science
Soumaya Kouidhi, Farhat Ben Ayed, Amel Benammar Elgaaied
Currently, a marked number of clinical trials on cancer treatment have revealed the success of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor-specific T cells. However, the therapeutic efficacy of cancer immunotherapies is only restricted to a small fraction of patients. A deeper understanding of key mechanisms generating an immunosuppressive tumor microenvironment (TME) remains a major challenge for more effective antitumor immunity. There is a growing evidence that the TME supports inappropriate metabolic reprogramming that dampens T cell function, and therefore impacts the antitumor immune response and tumor progression...
2018: Frontiers in Immunology
Feriel Boussema, Andrew J Gross, Fatma Hmida, Brahim Ayed, Hatem Majdoub, Serge Cosnier, Abderrazak Maaref, Michael Holzinger
Two new inorganic-organic hybrid materials based on heteropolyoxometalates (POMs): (C4 H10 N)6 [P2 Mo18 O62 ]·4H2 O (P2 Mo18 ) and (C6 H8 NO)4 [H2 P2 W18 O62 ]·6H2 O (P2 W18 ) are reported as mediators for electron transfer between FAD-dependent glucose dehydrogenase (FAD-GDH) and a multiwalled carbon nanotube (MWCNT) matrix for glucose biofuel cell and biosensor applications. These polyoxometalates were chosen due to their promising redox behavior in a potential range for mediated electron transfer with the glucose oxidizing enzyme, FAD-GDH...
February 28, 2018: Biosensors & Bioelectronics
Zisis Gatzioufas, Georgios D Panos, Mohamed Elalfy, Aye Khine, Samer Hamada, Damian Lake, Nikos Kozeis, Miltos Balidis
PURPOSE: To investigate the potential impact of cone eccentricity on visual outcomes after Keraring (Mediphacos, Belo Horizonte, Brazil) implantation for keratoconus. METHODS: Nineteen eyes from 19 patients with keratoconus who underwent femtosecond laser-assisted Keraring implantation for keratoconus were included in this retrospective study. Uncorrected visual acuity (UDVA), corrected visual acuity (CDVA), keratometric readings, central corneal thickness, maximum keratometric distance from corneal apex (DKmax), corneal thinnest point from corneal apex (DTh), and coma were evaluated preoperatively and 6 months after the Keraring implantation...
March 1, 2018: Journal of Refractive Surgery
Alexis H Bennett, Marie-Francoise O'Donohue, Stacey R Gundry, Aye T Chan, Jeffrey Widrick, Isabelle Draper, Anirban Chakraborty, Yi Zhou, Leonard I Zon, Pierre-Emmanuel Gleizes, Alan H Beggs, Vandana A Gupta
Gene expression in a tissue-specific context depends on the combined efforts of epigenetic, transcriptional and post-transcriptional processes that lead to the production of specific proteins that are important determinants of cellular identity. Ribosomes are a central component of the protein biosynthesis machinery in cells; however, their regulatory roles in the translational control of gene expression in skeletal muscle remain to be defined. In a genetic screen to identify critical regulators of myogenesis, we identified a DEAD-Box RNA helicase, DDX27, that is required for skeletal muscle growth and regeneration...
March 2018: PLoS Genetics
Liv Knutzen, Christina Aye, Hannah Anderson-Knight, Elena Svirko, Lawrence Impey
INTRODUCTION: The aim of this paper was to determine if arteriovenous differences of pH and PCO2 are useful predictors of adverse neonatal outcome in acidemic neonates. MATERIAL AND METHODS: An established database of 8759 term, singleton, non-anomalous neonates with validated cord gases and outcomes (Encephalopathy (Grade 2/ 3), Apgar <7 at 5 minutes and composite neonatal outcomes of neurological and systemic involvement) was used. Analysis was of the cohort of the 520 acidemic (arterial pH <7...
March 7, 2018: Acta Obstetricia et Gynecologica Scandinavica
M Hassanalian, S Ben Ayed, M Ali, P Houde, C Hocut, A Abdelkefi
The thermal effects of wing color in flight is investigated in four species of birds with respect to their flight routes, migration time, and geometric and behavioral characteristics. Considering the marine and atmospheric characteristics of these flight routes, a thermal analysis of the birds' wings is performed during their migration. The surrounding fluxes including the ocean flux and the solar irradiance are considered in an energy balance in order to determine the skin temperature of both sides of the wing...
February 2018: Journal of Thermal Biology
Manuela Aseye Ayele Ayee, Elizabeth LeMaster, Tao Teng, James Lee, Irena Levitan
Regulation of cell volume is a fundamental property of all mammalian cells. Multiple signaling pathways are known to be activated by cell swelling and to contribute to cell volume homeostasis. Although cell mechanics and membrane tension have been proposed to couple cell swelling to signaling pathways, the impact of swelling on cellular biomechanics and membrane tension have yet to be fully elucidated. In this study, we use atomic force microscopy under isotonic and hypotonic conditions to measure mechanical properties of endothelial membranes including membrane stiffness, which reflects the stiffness of the submembrane cytoskeleton complex, and the force required for membrane tether formation, reflecting membrane tension and membrane-cytoskeleton attachment...
February 27, 2018: Biophysical Journal
Mohammed Saeed Zayed Al-Ayed
This study aimed at investigating the potential ghrelin relaxing effect on guinea pig isolated tracheal smooth muscle (TSM). Using an in vitro experimental approach, the physiological role of the airway epithelium on smooth muscle relaxation has been investigated by analyzing the dose-response curves for carbachol- or histamine-induced contractions on epithelium intact versus denuded tracheal tissue. The relaxant effect of ghrelin (5-200 μmol/L) then investigated on carbachol-contracted, non-sensitized, and ovalbumin (OVA)-sensitized guinea pig TSM with an intact or denuded epithelium...
February 26, 2018: Pflügers Archiv: European Journal of Physiology
Sandar Aye, Suman S Majumdar, Myo Minn Oo, Jaya Prasad Tripathy, S Satyanarayana, Nang Thu Thu Kyaw, Khine Wut Yee Kyaw, Nay Lynn Oo, Saw Thein, Myat Kyaw Thu, Kyaw Thu Soe, Si Thu Aung
OBJECTIVES: We assessed the effect of an active case finding (ACF) project on tuberculosis (TB) case notification and the yields from a household and neigbourhood intervention (screening contacts of historical index TB patients diagnosed >24months ago) and a community intervention (screening attendants of health education sessions/mobile clinics). DESIGN: Cross-sectional analysis of project records, township TB registers and annual TB reports. RESULTS: In the household and neigbourhood intervention, of 56,709 people screened, 1,076 were presumptive TB and 74 patients were treated for active TB with a screening yield of 0...
February 21, 2018: International Journal of Infectious Diseases: IJID
Ameni Ayed, Nedra Slama, Houda Mankai, Sarra Bachkouel, Salem ElKahoui, Olfa Tabbene, Ferid Limam
A novel actinomycete strain designated S2T was isolated from Tunisian rhizosphere soil of Lavandula officinalis. This isolate exhibited broad spectrum antibacterial activity against several Gram-positive and Gram-negative bacteria and also antifungal activity against yeast and filamentous fungi. The isolate S2T presents morphological and chemotaxonomic characteristics typical of the members of the genus Streptomyces. Whole cell hydrolysates of S2T were found to contain LL-diaminopimelic acid. The major fatty acids were identified as C16:0, anteiso-C15:0 and iso-C16:0 whereas the predominant menaquinones were found to be MK-9(H6) and MK-9(H8)...
February 20, 2018: Antonie Van Leeuwenhoek
Edward J Brignole, Kuang-Lei Tsai, Johnathan Chittuluru, Haoran Li, Yimon Aye, Pawel A Penczek, JoAnne Stubbe, Catherine L Drennan, Francisco Asturias
Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by cryo-electron microscopy (EM) of a dATP-inhibited state of human RNR. This structure, which was determined in the presence of substrate CDP and allosteric regulators ATP and dATP, has three α2 units arranged in an α6 ring...
February 20, 2018: ELife
Jihen Jdidi, Yosra Mejdoub, Sourour Yaich, Houda Ben Ayed, Mondher Kassis, Habib Fki, Ines Ayadi, Jamel Damak
In a context of economic difficulties, the Tunisian government is required to find solutions to meet the expectations of the population. Health sector is one of the critical areas requiring radical reform. The objective of this paper is to find the place of public private partnership project in the harmonious development of both public and private sectors in Tunisia. Indeed, the Tunisian health system consists of two main sectors: the public sector, and the private sector, booming since the 90s. Tunisian infrastructure and staff resources distribution is characterised by a very significant regional disparity, to the detriment of the interior regions, which is more pronounced in the private sector...
March 2017: La Tunisie Médicale
Ralph W Aye Md
No abstract text is available yet for this article.
January 31, 2018: American Journal of Surgery
Maryam K Al Badi, Ibrahim Al-Alwan, Mohammed Al-Dubayee, Ayed Al-Anzi, Maram S Al Turki, Noura Aloudah, Khaled O Alsaad
Oncocytic tumors are epithelial neoplasms that occur in various organs, including adrenal glands. Oncocytic adrenocortical adenomas and carcinomas are uncommon but well-known pathological entities in adults. However, generally oncocytic tumors, particularly in the adrenal glands, are very rare in the pediatric age-group. Most oncocytic adrenal tumors are not functional. We present a rare case of right-sided, functional oncocytic adrenocortical adenoma in a 5-year-old boy, who presented with clinical manifestations of precocious puberty and Cushing syndrome...
January 1, 2018: Pediatric and Developmental Pathology
Zhan Xu, Hao Guo
Recent persuasion theories and some empirical studies indicate that emotional responses can be more persuasive than cognitive evaluations under certain circumstances. The aim of this meta-analysis was to compare the effects of emotions and perceived risk on health-related intentions and behavior. Ten studies which examined anticipated emotions (AdE) and 19 studies which examined anticipatory emotions (AyE) were included. AdE was moderately associated with health intention (r = 0.38, 95% CI 0.24-0.51) and behavior (r = 0...
February 5, 2018: Health Communication
M Saied, Rafik Gatri, Abdullah Sulaiman Al-Ayed, Youssef Arfaoui, Mohamed Moncef El Gaied
Background: α-Methylene cycloalkanones are considered of interest because of their biological activity. Herein, in this paper the synthesis of (±) HomoSarkomycine Esters was described and characterized. Methods: Using Bylis-Hillman adducts, triethlorthoacetate and propanoic acid, (±) HomoSarkomycine Esters could be synthesized by smoothly Johnson-Claisen rearrangement. Results: A small library of target compounds was prepared under optimized reaction conditions in moderate yields...
March 2017: Letters in Organic Chemistry
Sanjna L Surya, Marcus J C Long, Daniel A Urul, Yi Zhao, Emily J Mercer, Islam M Elsaid, Todd Evans, Yimon Aye
Small heat shock protein (sHSP)-B7 (HSPB7) is a muscle-specific member of the non-ATP-dependent sHSPs. The precise role of HSPB7 is enigmatic. Here we disclose that zebrafish Hspb7 is a kinetically-privileged sensor able to react rapidly with native reactive electrophilic signals (RES), when only sub-stoichiometric amounts of RES are available in proximity to Hspb7 expressed in living cells. Among the two Hspb7-cysteines, this RES-sensing is fulfilled by a single cysteine (C117). Purification and characterizations in vitro reveal that the rate for RES-adduction is among the most efficient reported for protein-cysteines with native carbonyl-based-RES...
February 3, 2018: ACS Chemical Biology
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