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https://www.readbyqxmd.com/read/28406708/pack-year-cigarette-smoking-history-for-determination-of-lung-cancer-screening-eligibility-comparison-of-the-electronic-medical-record-versus-a-shared-decision-making-conversation
#1
Hannah E Modin, Joelle T Fathi, Christopher R Gilbert, Candice L Wilshire, Andrew K Wilson, Ralph W Aye, Alexander S Farivar, Brian E Louie, Eric Vallières, Jed A Gorden
RATIONALE: Implementation of lung cancer screening programs is occurring across the United States. Programs vary in approaches to patient identification and shared decision making. The eligibility of persons referred to screening programs, the outcomes of eligibility determination during shared decision making, and the potential for the electronic medical record to identify eligible individuals have not been well described. OBJECTIVES: Our objectives were to assess the eligibility of individuals referred for lung cancer screening, and compare information extracted from the electronic medical record to information derived from a shared decision making conversation for the determination of eligibility for lung cancer screening...
April 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28399117/disproportionate-cardiac-hypertrophy-during-early-postnatal-development-in-infants-born-preterm
#2
Christina Y L Aye, Adam J Lewandowski, Pablo Lamata, Ross Upton, Esther Davis, Eric O Ohuma, Yvonne Kenworthy, Henry Boardman, Samuel Wopperer, Alice Packham, Satish Adwani, Kenny McCormick, Aris T Papageorghiou, Paul Leeson
BACKGROUND: Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. METHODS: Cardiac ultrasound was performed on 392 infants (33% preterm at mean gestation 34+/-2 weeks). Scans were performed during fetal development in 137, at birth and three months postnatal age in 200 and during both fetal and postnatal development in 55...
April 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28386491/multidrug-resistant-pseudomonas-mycotic-pseudoaneurysm-following-cardiac-transplant-bridged-by-ventricular-assistant-device
#3
C Aye, M Williams, R Horvath
Mycotic pseudoaneurysm of aorta following cardiac surgery is rare but is highly fatal if it is unrecognized and untreated. Here, we report a case of a 45-year-old male patient who presented with rapidly progressive multiple pseudoaneurysms of the ascending aorta infected with multidrug resistant (MDR) Pseudomonas aeruginosa at 5 weeks after cardiac transplantation, on a background of prior bridging therapy with left ventricular assistant device (LVAD). The patient was successfully treated with the newer cephalosporin, Ceftolozane/Tazobactam, in combination with surgery...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28385497/angptl3-a-gene-a-protein-a-new-target-aye-there-s-the-rub
#4
EDITORIAL
Jacques Genest
No abstract text is available yet for this article.
March 29, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28384224/socio-environmental-exposures-and-health-outcomes-among-persons-with-sickle-cell-disease
#5
Monika R Asnani, Jennifer Knight Madden, Marvin Reid, Lisa-Gaye Greene, Parris Lyew-Ayee
There is much variability in the expression of sickle cell disease (SCD) and recent works suggest that environmental and social factors may also influence this variability. This paper aims to use geographic information systems technology to examine the association between socio-environmental exposures and health outcomes in all persons who have attended or currently attend the Sickle Cell Unit in Jamaica. Rural patients presented for clinical care at older ages and had less annual visits to clinic. Persons travelled relatively long distances to seek SCD care and those travelling longer had less health maintenance visits...
2017: PloS One
https://www.readbyqxmd.com/read/28367656/prevalence-of-anemia-and-hemoglobin-disorders-among-school-children-in-myanmar
#6
Saw Thu Wah, Yoon Shwe Yi, Aye Aye Khin, Chotiros Plabplueng, Pornlada Nuchnoi
The prevalence of anemia is high in the population of Myanmar and hypochromic microcytic anemia (HMA) is predominant. The objective of our study was to determine the prevalence of anemia and causes of HMA among school children. A cross-sectional study was conducted on 239 children from Thanlyin and Insein Townships, Yangon Region, Myanmar. Complete blood count (CBC) and blood film morphology was examined on venous blood samples. Hypochromic microcytic anemia cases were subsequently analyzed for serum ferritin and cellulose acetate hemoglobin (Hb) electrophoresis...
April 2, 2017: Hemoglobin
https://www.readbyqxmd.com/read/28364150/repair-of-symptomatic-paraesophageal-hernias-in-elderly-70%C3%A2-years-patients-results-in-sustained-quality-of-life-at-5%C3%A2-years-and-beyond
#7
Oleg V Merzlikin, Brian E Louie, Alexander S Farivar, Dale Shultz, Ralph W Aye
BACKGROUND: Paraesophageal hernias (PEHs) involve herniation of stomach and/or other viscera into the mediastinum. These commonly occur in the elderly and can severely limit quality of life. Short term outcomes of repaired PEH demonstrated low morbidity and significant improvement in quality of life, but long-term data for all patients, especially the elderly, are lacking. METHODS: Retrospective chart review of a prospectively collected database of patients aged 70 or greater with a symptomatic PEH repaired 5+ years ago...
March 31, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28357909/nitrite-enhances-liver-graft-protection-against-cold-ischemia-reperfusion-injury-through-a-nos-independent-pathway
#8
Amani Cherif-Sayadi, Kaouther Hadj Ayed-Tka, Mohamed Amine Zaouali, Mohamed Bejaoui, Najet Hadj-Abdallah, Ahlem Bouhlel, Hassen Ben Abdennebi
INTRODUCTION: Nitrite has been found to protect liver graft from cold preservation injury. However, the cell signaling pathway involved in this protection remains unclear. Here, we attempt to clarify if the NOS pathway by using the NOS inhibitor, L-NAME (L-N(G)-Nitroarginine methyl ester). ANIMALS AND METHODS: Rat livers were conserved for 24 h at 4°C in (IGL-1) solution enriched or not with nitrite at 50 nM. In a third group, rats were pretreated with 50 mg/kg of L-NAME before their liver procurement and preservation in IGL-1 supplemented with nitrite (50 nM) and L-NAME (1 mM)...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28352668/genomic-profiling-reveals-mutational-landscape-in-parathyroid-carcinomas
#9
Chetanya Pandya, Andrew V Uzilov, Justin Bellizzi, Chun Yee Lau, Aye S Moe, Maya Strahl, Wissam Hamou, Leah C Newman, Marc Y Fink, Yevgeniy Antipin, Willie Yu, Mark Stevenson, Branca M Cavaco, Bin T Teh, Rajesh V Thakker, Hans Morreau, Eric E Schadt, Robert Sebra, Shuyu D Li, Andrew Arnold, Rong Chen
Parathyroid carcinoma (PC) is an extremely rare malignancy lacking effective therapeutic intervention. We generated and analyzed whole-exome sequencing data from 17 patients to identify somatic and germline genetic alterations. A panel of selected genes was sequenced in a 7-tumor expansion cohort. We show that 47% (8 of 17) of the tumors harbor somatic mutations in the CDC73 tumor suppressor, with germline inactivating variants in 4 of the 8 patients. The PI3K/AKT/mTOR pathway was altered in 21% of the 24 cases, revealing a major oncogenic pathway in PC...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28352660/tlr7-8-adjuvant-overcomes-newborn-hyporesponsiveness-to-pneumococcal-conjugate-vaccine-at-birth
#10
David J Dowling, Simon D van Haren, Annette Scheid, Ilana Bergelson, Dhohyung Kim, Christy J Mancuso, Willemina Foppen, Al Ozonoff, Lynn Fresh, Terese B Theriot, Andrew A Lackner, Raina N Fichorova, Dmitri Smirnov, John P Vasilakos, Joe M Beaurline, Mark A Tomai, Cecily C Midkiff, Xavier Alvarez, James L Blanchard, Margaret H Gilbert, Pyone Pyone Aye, Ofer Levy
Infection is the most common cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, newborns fail to respond optimally to most vaccines. Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of human newborn leukocytes to most candidate adjuvants, including most TLR agonists, are functionally distinct. Herein, we demonstrate that 3M-052 is a locally acting lipidated imidazoquinoline TLR7/8 agonist adjuvant in mice, which, when properly formulated, can induce robust Th1 cytokine production by human newborn leukocytes in vitro, both alone and in synergy with the alum-adjuvanted pneumococcal conjugate vaccine 13 (PCV13)...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28351532/multiple-and-recurrent-cerebral-infarctions-in-a-patient-with-idiopathic-thrombocytopenic-purpura
#11
Aissi Mouna, Masmoudi Rim, Zahra Kmira, Mahmoud Imene, Mokni Narjes, N Daouassi, Frih-Ayed Mahbouba
No abstract text is available yet for this article.
March 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28344216/major-bleeding-events-in-jordanian-patients-undergoing-percutaneous-coronary-intervention-pci-incidence-associated-factors-impact-on-prognosis-and-predictability-of-the-crusade-bleeding-risk-score-results-from-the-first-jordanian-pcr-pcr1
#12
Mohamad Jarrah, Ayman Hammoudeh, Osama Okkeh, Yousef Khader, Sahem Gharaibeh, Laith Nasser, Amro Rasheed, Ayed Al-Hindi, Mohammad Mohealdeen, Haneen Kharabsheh, Hanan Abunimeh, Enas Hijjih, Lina Tashman, Delia Omar, Nadeen Kufoof
OBJECTIVE: Determine the incidence of major bleeding events, their risk factors, and their impact on prognosis in Jordanian patients undergoing percutaneous coronary intervention (PCI). Evaluate the ability of the CRUSADE bleeding risk score (BRS) to predict major bleeding. METHODS: Major bleeding events were defined according to the CRUSADE classification and their incidence was evaluated from hospital admission to one year of follow up. The CRUSADE bleeding risk score was calculated for each patient during the index admission...
March 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28330277/classical-and-bayesian-predictions-applied-to-bacillus-toxin-production
#13
Karim Ennouri, Rayda Ben Ayed, Maura Mazzarello, Ennio Ottaviani, Fathi Hertelli, Hichem Azzouz
Bacillus thuringiensis is a bacterium with unusual properties that make it useful for pest control in ecoagriculture. It can form a parasporal crystal containing polypeptides (also called delta-endotoxins). These entomopathogenic toxins are made during the stationary phase of the bacterial growth cycle and were initially characterized as an insect pathogen. Nowadays, the use of saturated two-level designs is very popular. This method is especially used in industrial applications where the cost of experiments is expensive...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329118/comparison-of-surgical-approach-and-extent-of-resection-for-masaoka-koga-stage-i-and-ii-thymic-tumours-in-europe-north-america-and-asia-an-international-thymic-malignancy-interest-group-retrospective-database-analysis%C3%A2
#14
Wentao Fang, Xiaopan Yao, Alberto Antonicelli, Zhitao Gu, Frank Detterbeck, Eric Vallières, Ralph W Aye, Alexander S Farivar, James Huang, Yue Shang, Brian E Louie
OBJECTIVES: Surgeons at different institutions worldwide choose different types of operations for thymic tumours. It is not known whether these differences affect the outcomes of the patients. METHODS: A total of 1430 patients with Masaoka-Koga pathological Stage I-II thymic tumours without myasthenia gravis or pre-treatment were identified from the International Thymic Malignancy Interest Group retrospective database. Outcomes of patients from 3 major continents (Europe, North America and Asia) were compared...
February 28, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28302077/clinical-and-laboratory-parameters-associated-with-acute-kidney-injury-in-patients-with-snakebite-envenomation-a-prospective-observational-study-from-myanmar
#15
Kyi-Phyu Aye, Vipa Thanachartwet, Chit Soe, Varunee Desakorn, Khin-Thida Thwin, Supat Chamnanchanunt, Duangjai Sahassananda, Thanom Supaporn, Visith Sitprija
BACKGROUND: Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-related AKI, (2) assess factors at presentation that are associated with snakebite-related AKI, and (3) determine the outcomes of patients with snakebite-related AKI. METHODS: We conducted a prospective observational study of patients with snake envenomation at the three academic tertiary care hospitals in Yangon, Myanmar between March 2015 and June 2016...
March 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28298235/clinical-and-molecular-surveillance-of-drug-resistant-vivax-malaria-in-myanmar-2009-2016
#16
Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han, Eun-Taek Han
BACKGROUND: One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being explored globally, there are few studies on drug resistance vivax malaria. METHODS: To assess the spread of drug-resistant vivax malaria in Myanmar, a multisite, prospective, longitudinal study with retrospective analysis of previous therapeutic efficacy studies, was conducted...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28293174/editorial-minding-glial-cells-in-the-novel-understandings-of-mental-illness
#17
EDITORIAL
Takahiro A Kato, Aye M Myint, Johann Steiner
No abstract text is available yet for this article.
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28291805/socioeconomic-factors-associated-with-severe-acute-malnutrition-in-jamaica
#18
Debbie S Thompson, Novie Younger-Coleman, Parris Lyew-Ayee, Lisa-Gaye Greene, Michael S Boyne, Terrence E Forrester
OBJECTIVES: Severe acute malnutrition (SAM) is an important risk factor for illness and death globally, contributing to more than half of deaths in children worldwide. We hypothesized that SAM is positively correlated to poverty, low educational attainment, major crime and higher mean soil concentrations of lead, cadmium and arsenic. METHODS: We reviewed admission records of infants admitted with a diagnosis of SAM over 14 years (2000-2013) in Jamaica. Poverty index, educational attainment, major crime and environmental heavy metal exposure were represented in a Geographic Information System (GIS)...
2017: PloS One
https://www.readbyqxmd.com/read/28280687/clear-cell-adenocarcinoma-of-the-female-urethra-mimicking-cystocele
#19
Yassine Ayari, Walid Kerkeni, Nadia Znaidi, A Blel, A Bouzouita, H Ayed, Mohamed Cherif, Mohamed Riadh Ben Slama, Amine Derouiche, Soumaya Rammeh, Mohamed Chebil
Clear cell adenocarcinoma of the urethra is an extremely rare neoplasm mainly described in women. Anterior pelvic exenteration was the treatment performed in most reported cases. It seems to have poorer prognosis than urothelial carcinomas.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28279439/erratum-%C3%A3-l%C3%A2-article-%C3%A2-%C3%A2-analysis-of-the-2015%C3%A2-british-guidelines-on-the-prevention-and-management-of-tumor-lysis-syndrome%C3%A2-%C3%A2-rev-med-interne-38-2017-36%C3%A2-43
#20
A Dupré, C Mousseaux, A Bouguerba, S Ayed, J Barchazs, M Boukari, D Goldgran-Toledano, C Bornstain, F Vincent
No abstract text is available yet for this article.
May 2017: La Revue de Médecine Interne
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