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https://www.readbyqxmd.com/read/27904420/role-of-the-whole-body-vibration-machine-in-the-prevention-and-management-of-osteoporosis-in-old-age-a-systematic-review
#1
REVIEW
Myint Swe, Biju Benjamin, Aye Aye Tun, Sandheep Sugathan
A literature search of related articles was carried out in electronic data sources. Initially, 276 randomised controlled trials related to the title were collected, after which 44 were selected using the keywords. Overlapping articles, articles with a study duration of less than six months, and studies involving young participants were removed from the list. The remaining 20 articles were checked for entitlement using the PEDro scale. A total of nine eligible articles with 1486 participants were analysed. Seven trials used dual-energy x-ray absorptiometry (DXA) to measure bone mineral density (BMD)...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27878812/perioperative-blood-transfusion-does-it-influence-survival-and-cancer-progression-in-metastatic-spine-tumor-surgery
#2
Aye Sandar Zaw, Shashidhar B Kantharajanna, Karthikeyan Maharajan, Barry Tan, Balamurugan Vellayappan, Naresh Kumar
BACKGROUND: Despite advances in surgical techniques for spinal metastases, there is often substantial blood loss, resulting in patients requiring blood transfusion during the perioperative period. Allogeneic blood transfusion (ABT) has been the main replenishment method for lost blood. However, the impact of ABT on cancer-related outcomes has been controversial in various studies. We aimed to evaluate the influence of perioperative ABT on disease progression and survival in patients undergoing metastatic spinal tumor surgery (MSTS)...
November 22, 2016: Transfusion
https://www.readbyqxmd.com/read/27876211/evaluation-of-anti-proliferative-and-anti-inflammatory-activities-of-pelagia-noctiluca-venom-in-lipopolysaccharide-interferon-%C3%AE-stimulated-raw264-7-macrophages
#3
Yosra Ayed, Rabiaa Manel Sghaier, Dhafer Laouini, Hassen Bacha
Components of Pelagia noctiluca (P. noctiluca) venom were evaluated for their anticancer and nitric Oxide (NO) inhibition activities. Three fractions, out of four, obtained by gel filtration on Sephadex G75 of P. noctiluca venom revealed an important selective anti-proliferative activity on several cell lines such as human bladder carcinoma (RT112), human glioblastoma (U87), and human myelogenous leukemia (K562) but not on mitogen-stimulated peripheral blood mononuclear cells. Interestingly, P. noctiluca components showed an important dose-dependent anti-inflammatory activity, through inhibition of NO production via transcriptional regulation of Inducible NO Synthase (iNOS), in IFN-γ/LPS stimulated RAW 264...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27875414/the-influence-of-histologic-subtype-in-predicting-survival-of-lung-cancer-patients-with-spinal-metastases
#4
Naresh Kumar, Kimberly-Anne Tan, Jiong Hao Tan, Aye S Zaw, Hwee Weng Dennis Hey, John Ruiz, Emily Stone
STUDY DESIGN: Retrospective analysis. SUMMARY OF BACKGROUND DATA: Recent advancements in systemic treatment of lung cancer have significantly improved the survival of patients with certain histolopathologic and molecular subtypes. Existing prognostic scores do not account for this and patients with lung cancer spinal metastases are grouped together as poor prognostic candidates, and consequently, some may be inappropriately denied palliative spine surgery. OBJECTIVE: The objective of the study was to study whether the expected survival in patients with lung cancer spinal metastases is affected by histolopathologic and molecular subtypes in the context of modern systemic therapy...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27875215/local-submodularization-for-binary-pairwise-energies
#5
Lena Gorelick, Yuri Boykov, Olga Veksler, Ismail Ben Ayed, Andrew Delong
Many computer vision problems require optimization of binary non-submodular energies. We propose a general optimization framework based on local submodular approximations (LSA). Unlike standard LP relaxation methods that linearize the whole energy globally, our approach iteratively approximates the energy locally. On the other hand, unlike standard local optimization methods (e.g., gradient descent or projection techniques) we use non-linear submodular approximations and optimize them without leaving the domain of integer solutions...
November 18, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/27864452/identifying-progression-predictors-of-breast-ductal-carcinoma-in-situ
#6
REVIEW
Joe Yeong, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Ductal carcinoma in situ (DCIS) refers to neoplastic epithelial cells proliferating within the mammary ducts of the breast, which have not breached the basement membrane nor invaded surrounding tissues. Traditional thinking holds that DCIS represents an early step in a linear progression towards invasive ductal carcinoma (IDC). However, as only approximately half of DCIS cases progress to IDC, important questions around the key determinants of malignant progression need to be answered. Recent studies have revealed that molecular differences between DCIS and IDC cells are not found at the genomic level; instead, altered patterns of gene expression and post-translational regulation lead to distinct transcriptomic and proteomic profiles...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27852262/e-cadherin-genetic-variants-predict-survival-outcome-in-breast-cancer-patients
#7
Hager Memni, Yosra Macherki, Zahra Klayech, Ahlem Ben-Haj-Ayed, Karim Farhat, Yassmine Remadi, Sallouha Gabbouj, Wijden Mahfoudh, Nadia Bouzid, Noureddine Bouaouina, Lotfi Chouchane, Abdelfattah Zakhama, Elham Hassen
BACKGROUND: E-cadherin is a major component of adherens junctions that regulates cell shape and maintains tissue integrity. A complete loss or any decrease in cell surface expression of E-cadherin will interfere with the cell-to-cell junctions' strength and leads to cell detachment and escape from the primary tumor site. In this prospective study, three functional single nucleotide polymorphisms (-347G/GA, rs5030625; -160C/A, rs16260; +54C/T, rs1801026), were found to modulate E-cadherin expression...
November 16, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27848157/competition-for-dead-trees-between-humans-and-aye-ayes-daubentonia-madagascariensis-in-central-eastern-madagascar
#8
Rose T Miller, Jean-Luc Raharison, Mitchell T Irwin
The destruction and degradation of forest habitats are major threats to the sustainability of lemur populations in Madagascar. Madagascan landscapes often contain forest fragments that represent refuges for native fauna, while also being used for firewood and timber by local human populations. As undisturbed forest becomes increasingly scarce, understanding resource competition between humans and wildlife in disturbed habitats will be increasingly important. We tested the hypothesis that Malagasy and aye-ayes (Daubentonia madagascariensis) compete for the limited number of dead trees in rainforest fragments at Tsinjoarivo, Madagascar...
November 15, 2016: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/27846043/aortic-stiffness-and-blood-pressure-variability-in-young-people-a-multimodality-investigation-of-central-and-peripheral-vasculature
#9
Henry Boardman, Adam J Lewandowski, Merzaka Lazdam, Yvonne Kenworthy, Polly Whitworth, Charlotte L Zwager, Jane M Francis, Christina Y L Aye, Wilby Williamson, Stefan Neubauer, Paul Leeson
INTRODUCTION: Increased blood pressure (BP) variability is a cardiovascular risk marker for young individuals and may relate to the ability of their aorta to buffer cardiac output. We used a multimodality approach to determine relations between central and peripheral arterial stiffness and BP variability. METHODS: We studied 152 adults (mean age of 31 years) who had BP variability measures based on SD of awake ambulatory BPs, 24-h weighted SD and average real variability (ARV)...
November 23, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27842869/isolation-and-biochemical-characterisation-of-a-bacteriocin-like-substance-produced-by-bacillus-amyloliquefaciens-an6
#10
Hanen Ben Ayed, Hana Maalej, Noomen Hmidet, Moncef Nasri
This study focuses on the isolation and characterisation of a peptide with bacteriocin-like properties from Bacillus amyloliquefaciens An6. Incubation conditions were optimised, and the effects of the incubation period and of carbon and nitrogen sources were investigated. The produced bacteriocin was partially purified with ammonium sulphate precipitation, dialysis and ultrafiltration and was then biochemically characterised. Maximum bacteriocin production was achieved after 48h of incubation in a culture medium containing 20g/L starch and 10g/L yeast extract, with an initial pH 8...
December 2015: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27813017/tri-comparison-of-laparoscopic-nissen-hill-and-nissen-hill-hybrid-repairs-for-uncomplicated-gastroesophageal-reflux-disease
#11
Andreas M Schneider, Ralph W Aye, Candice L Wilshire, Alexander S Farivar, Brian E Louie
BACKGROUND: A randomized controlled trial (RCT) showed that laparoscopic Nissen fundoplication (LNF) and Hill (LHR) repairs are equivalent in treating uncomplicated GERD. We combined both repairs to create a laparoscopic Nissen-Hill Hybrid repair (HYB). The purpose of this study is to compare clinical and objective outcomes of a matched group of HYB to the two cohorts of the RCT. METHODS: A retrospective analysis of prospectively collected data from the RCT and a prospectively collected data base was performed...
November 3, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27811832/laparoscopic-assisted-altemeier-s-procedure-for-recurrent-strangulated-rectal-prolapse-a-case-report
#12
Wael M Al-Ameen, Antonio Privitera, Amal Al-Ayed, Khalid Sabr
BACKGROUND Rectal prolapse is an uncommon disease that usually requires surgical intervention. Several techniques have been described with either an abdominal or perineal approach, the latter having a higher recurrence rate. In case of irreducible and strangulated full-thickness prolapse, a perineal approach is necessary, and efforts should be made to reduce recurrence rates. CASE REPORT A 39-year-old mentally retarded woman presented with a painful, recurrent, strangulated sigmoid prolapse following a perineal recto-sigmoidectomy (Altemeier's procedure) for strangulated rectal prolapse 2 months previously...
November 4, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27809314/t-rex-on-demand-redox-targeting-in-live-cells
#13
Saba Parvez, Marcus J C Long, Hong-Yu Lin, Yi Zhao, Joseph A Haegele, Vanha N Pham, Dustin K Lee, Yimon Aye
This protocol describes targetable reactive electrophiles and oxidants (T-REX)-a live-cell-based tool designed to (i) interrogate the consequences of specific and time-resolved redox events, and (ii) screen for bona fide redox-sensor targets. A small-molecule toolset comprising photocaged precursors to specific reactive redox signals is constructed such that these inert precursors specifically and irreversibly tag any HaloTag-fused protein of interest (POI) in mammalian and Escherichia coli cells. Syntheses of the alkyne-functionalized endogenous reactive signal 4-hydroxynonenal (HNE(alkyne)) and the HaloTag-targetable photocaged precursor to HNE(alkyne) (also known as Ht-PreHNE or HtPHA) are described...
December 2016: Nature Protocols
https://www.readbyqxmd.com/read/27801835/dietary-gluten-induced-gut-dysbiosis-is-accompanied-by-selective-upregulation-of-micrornas-with-intestinal-tight-junction-and-bacteria-binding-motifs-in-rhesus-macaque-model-of-celiac-disease
#14
Mahesh Mohan, Cheryl-Emiliane T Chow, Caitlin N Ryan, Luisa S Chan, Jason Dufour, Pyone P Aye, James Blanchard, Charles P Moehs, Karol Sestak
The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those from 6 healthy, age- and diet-matched peers. A total of 48 samples representing both groups were studied using V4 16S rRNA gene DNA analysis. Samples from GS macaques were further characterized based on type of diet administered: conventional monkey chow, i.e., wheat gluten-containing diet (GD), gluten-free diet (GFD), barley gluten-derived diet (BOMI) and reduced gluten barley-derived diet (RGB)...
October 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27789323/-results-of-conservative-management-of-emphysematous-pyelonephritis
#15
Ahmed Saadi, Haroun Ayed, Abderrazak Bouzouita, Mohamed Cherif, Walid Kerkeni, Selim Selmi, Riadh Ben Slama, Amine Derouiche, Mohamed Chebil
INTRODUCTION: Emphysematous pyelonephritis (EPN) is a rare and severe, necrotizing infection of the kidney. Diagnosis should be precocious based on computed tomography (CT). Its management remains controversial and its treatment is currently increasingly conservative. The aim of this paper is to discuss the conservative treatment of this disease through our experience in 21 patients. MATERIAL AND METHODS: A retrospective analysis including 21 patients managed conservatively for an emphysematous pyelonephritis in our department from January 2010 to April 2015...
October 24, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27782885/%C3%AE-protocadherin-structural-diversity-and-functional-implications
#16
Kerry Marie Goodman, Rotem Rubinstein, Chan Aye Thu, Seetha Mannepalli, Fabiana Bahna, Göran Ahlsén, Chelsea Rittenhouse, Tom Maniatis, Barry Honig, Lawrence Shapiro
Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments comprising cell-cell recognition regions of mouse γ-Pcdhs γA1, γA8, γB2, and γB7 revealing trans-homodimers, and of C-terminal ectodomain fragments from γ-Pcdhs γA4 and γB2, which depict cis-interacting regions in monomeric form. Together these structures span the entire γ-Pcdh ectodomain...
October 26, 2016: ELife
https://www.readbyqxmd.com/read/27776691/combination-of-tacrolimus-and-mycophenolate-mofetil-induces-oxidative-stress-and-genotoxicity-in-spleen-and-bone-marrow-of-wistar-rats
#17
Hanen Ferjani, Hossam Draz, Salwa Abid, Abedellatif Achour, Hassen Bacha, Imen Boussema-Ayed
Tacrolimus (TAC) and mycophenolate mofetil (MMF) are common immunosuppressive drugs used to avoid immunological rejection of transplanted organs. The risk of developing cancer is the most critical complication in organ transplant recipients undergoing immunosuppressive therapy. This study aims to explore the cytotoxic and genotoxic effects of TAC and MMF alone or combined orally administrated on spleen and bone marrow of Wistar rats. Our results showed that TAC (2.4; 24 and 60mg/kg) and MMF (5; 50 and 125mg/kg) induced a genotoxic effect on rat bone marrow...
November 1, 2016: Mutation Research
https://www.readbyqxmd.com/read/27771469/the-association-between-functional-hla-g-14bp-insertion-deletion-and-3142-c-g-polymorphisms-and-susceptibility-to-multiple-sclerosis
#18
Nadia Ben Fredj, Kaouthar Sakly, Daria Bortolotti, Mouna Aissi, Mahbouba Frih-Ayed, Antonella Rotola, Elisabetta Caselli, Franscesca Cura, Nabil Sakly, Mahjoub Aouni, Dario Di Luca, Roberta Rizzo
We aimed to investigate two main polymorphisms in the 3' untranslated region (3'UTR) of the HLA-G gene [14bp insertion/deletion (INS/DEL) and +3142 C>G] and to assess their impact on the soluble HLA-G (sHLA-G) production in patients with multiple sclerosis (MS). This study included 60 patients with relasping-remitting (RR) MS and 112 healthy donors (HD). Mutations were identified by PCR and PCR-RFLP, and serum sHLA-G quantification was performed by ELISA. For the 14bp INS/DEL polymorphism, variants frequencies were similar in patients and controls, whereas a significant increased frequency of the +3142 G allele was found in MS patients compared to HD (63...
October 19, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27756394/malaria-incidence-in-myanmar-2005-2014-steady-but-fragile-progress-towards-elimination
#19
Thet Thet Mu, Aye Aye Sein, Tint Tint Kyi, Myo Min, Ne Myo Aung, Nicholas M Anstey, Myat Phone Kyaw, Chit Soe, Mar Mar Kyi, Josh Hanson
BACKGROUND: There has been an impressive recent reduction in the global incidence of malaria, but the development of artemisinin resistance in the Greater Mekong Region threatens this progress. Increasing artemisinin resistance is particularly important in Myanmar, as it is the country in the Greater Mekong Region with the greatest malaria burden. If malaria is to be eliminated in the region, it is essential to define the spatial and temporal epidemiology of the disease in Myanmar to inform control strategies optimally...
October 18, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27743641/spine-labeling-in-axial-magnetic-resonance-imaging-via-integral-kernels
#20
Brandon Miles, Ismail Ben Ayed, Seyed-Parsa Hojjat, Michael H Wang, Shuo Li, Aaron Fenster, Gregory J Garvin
This study investigates a fast integral-kernel algorithm for classifying (labeling) the vertebra and disc structures in axial magnetic resonance images (MRI). The method is based on a hierarchy of feature levels, where pixel classifications via non-linear probability product kernels (PPKs) are followed by classifications of 2D slices, individual 3D structures and groups of 3D structures. The algorithm further embeds geometric priors based on anatomical measurements of the spine. Our classifier requires evaluations of computationally expensive integrals at each pixel, and direct evaluations of such integrals would be prohibitively time consuming...
December 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
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