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https://www.readbyqxmd.com/read/28729377/abundant-dystrophic-calcifications-mimicking-aortic-valve-abscess-in-a-patient-undergoing-elective-aortic-valve-replacement
#1
Adam L Booth, Christine Q Li, Ghannam Ayed Al-Dossari, Heather L Stevenson
Dystrophic calcifications of the aortic valve may cause symptomatic aortic stenosis and account for a significant portion of patients who undergo elective valve replacement. Calcifications appearing grossly as a cloudy fluid surrounding the aortic valve leaflets are an uncommon finding. Normally, calcified aortic valves are characterised by large, nodular masses within the aortic cusps. We report a case of dystrophic calcifications on a stenotic aortic valve encountered intraoperatively, which was suggestive of infective endocarditis and abscess formation...
July 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28722601/rabies-in-myanmar-prevalent-preventable-but-not-prioritized
#2
Thet Thet Mu, Aye Aye Sein, Chit Soe, Nan Phyu Phyu Aung, Tint Tint Kyi, Josh Hanson
Despite the availability of proven measures to prevent the disease, rabies now kills more people in Myanmar than malaria. Although there are challenges in controlling rabies in such a large and culturally diverse country, Myanmar's successful National Malaria Control Program demonstrates what can be achieved with sufficient political, financial, and scientific commitment. Presently, however, Myanmar lacks a comparable program to coordinate the multifaceted approach that is necessary to control rabies. The national government has invested heavily in improving access to postexposure prophylaxis, but there should also be an emphasis on other, more cost-effective strategies, particularly mass canine vaccination, which has been an essential component of successful rabies elimination programs in other countries...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719025/frequency-risk-factors-and-outcomes-of-central-nervous-system-relapse-in-lymphoma-patients-treated-with-dose-adjusted-epoch-plus-rituximab
#3
M K Malecek, A M Petrich, S Rozell, B Chu, S Trifilio, N Galanina, M Maurer, U Farooq, B Link, G S Nowakowski, C Nabhan, A O Ayed
Background Central nervous system (CNS) relapse in non-Hodgkin lymphoma (NHL) is a rare but serious complication that carries a poor prognosis. The use of infusional etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) for frontline treatment of diffuse large B cell lymphoma (DLBCL) is increasing, though little is known about incidence of and risk factors for CNS relapse with this regimen Patients and methods We completed a chart review of patients with NHL who received EPOCH-R as front line therapy...
July 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28701359/oxldl-induced-endothelial-proliferation-via-rho-rock-akt-p27-kip1-signaling-prevention-by-cholesterol-loading
#4
Chongxu Zhang, Crystal Adamos, Myung-Jin Oh, Jugajyoti Baruah, Manuela A A Ayee, Dolly Mehta, Kishore K Wary, Irena Levitan
Oxidized modifications of LDL (oxLDL) are known to play a major role in endothelial dysfunction and the development of atherosclerosis. In this study, we provide comparative analysis of the effects of two major types of oxLDL, copper oxidized LDL (Cu(2+)-oxLDL) and Lipoxygenase oxidized LDL (LPO-oxLDL) on proliferation of Human Aortic Endothelial Cells (HAECs). We show that Cu(2+)-oxLDL enhances HAECs proliferation in a dose and oxidation-dependent manner. Similarly, LPO-oxLDL also has a positive effect on HAECs proliferation...
July 12, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28701171/identification-and-characterization-of-single-nucleotide-polymorphism-markers-in-fads2-gene-associated-with-olive-oil-fatty-acids-composition
#5
Rayda Ben Ayed, Karim Ennouri, Hajer Ben Hlima, Slim Smaoui, Mohsen Hanana, Rim Mzid, Sezai Ercişli, Ahmed Rebai
BACKGROUND: Genotyping of the FAD2.1 and FAD2.3 polymorphisms in the fatty acid desaturase 2 gene (FADS2) shows that they are associated with the fatty acids composition of olive oil samples. However, these associations require further confirmation in the Tunisian olive oil cultivars, and little is known about the effect of polymorphisms in fatty acid-related genes on olive oil mono- and poly- unsaturated fatty acids distribution. METHODS: A set of olive oils from 12 Tunisian cultivars was chosen...
July 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28699084/egfr-mutation-testing-of-non-squamous-nsclc-impact-and-uptake-during-implementation-of-testing-guidelines-in-a-population-based-registry-cohort-from-northern-new-zealand
#6
Mark McKeage, Mark Elwood, Sandar Tin Tin, Prashannata Khwaounjoo, Phyu Aye, Angie Li, Karen Sheath, Phillip Shepherd, George Laking, Nicola Kingston, Christopher Lewis, Donald Love
BACKGROUND: Since 2013, clinical practice guidelines recommend EGFR mutation testing of non-squamous NSCLC to select advanced-stage patients for first-line treatment using EGFR-TKIs. OBJECTIVE: We aimed to determine population-based trends in the real-world uptake and impact in routine practice of these recently updated testing guidelines. PATIENTS AND METHODS: A population-based observational study was conducted of notifications to the New Zealand Cancer Registry of patients eligible for EGFR testing diagnosed in northern New Zealand between January 2010 and April 2014...
July 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28693552/chloroquine-efficacy-for-plasmodium-vivax-in-myanmar-in-populations-with-high-genetic-diversity-and-moderate-parasite-gene-flow
#7
Myo Win Htun, Nan Cho Nwe Mon, Khin Myo Aye, Chan Myae Hlaing, Myat Phone Kyaw, Irene Handayuni, Hidayat Trimarsanto, Dorina Bustos, Pascal Ringwald, Ric N Price, Sarah Auburn, Kamala Thriemer
BACKGROUND: Plasmodium vivax malaria remains a major public health burden in Myanmar. Resistance to chloroquine (CQ), the first-line treatment for P. vivax, has been reported in the country and has potential to undermine local control efforts. METHODS: Patients over 6 years of age with uncomplicated P. vivax mono-infection were enrolled into clinical efficacy studies in Myawaddy in 2014 and Kawthoung in 2012. Study participants received a standard dose of CQ (25 mg/kg over 3 days) followed by weekly review until day 28...
July 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28687738/a-possible-origin-population-of-pathogenic-intestinal-nematodes-strongyloides-stercoralis-unveiled-by-molecular-phylogeny
#8
Eiji Nagayasu, Myo Pa Pa Thet Hnin Htwe Aung, Thanaporn Hortiwakul, Akina Hino, Teruhisa Tanaka, Miwa Higashiarakawa, Alex Olia, Tomoyo Taniguchi, Soe Moe Thu Win, Isao Ohashi, Emmanuel Igwaro Odongo-Aginya, Khin Myo Aye, Mon Mon, Kyu Kyu Win, Kei Ota, Yukari Torisu, Siripen Panthuwong, Eisaku Kimura, Nirianne M Q Palacpac, Taisei Kikuchi, Tetsuo Hirata, Shidow Torisu, Hajime Hisaeda, Toshihiro Horii, Jiro Fujita, Wah Win Htike, Haruhiko Maruyama
Humans and dogs are the two major hosts of Strongyloides stercoralis, an intestinal parasitic nematode. To better understand the phylogenetic relationships among S. stercoralis isolates infecting humans and dogs and to assess the zoonotic potential of this parasite, we analyzed mitochondrial Cox1, nuclear 18S rDNA, 28S rDNA, and a major sperm protein domain-containing protein genes. Overall, our analyses indicated the presence of two distinct lineages of S. stercoralis (referred to as type A and type B). While type A parasites were isolated both from humans and dogs in different countries, type B parasites were found exclusively in dogs, indicating that the type B has not adapted to infect humans...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680094/the-importance-of-n-glycosylation-on-%C3%AE-3-integrin-ligand-binding-and-conformational-regulation
#9
Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu
N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits. Crystal structures of αIIbβ3 and αVβ3 have resolved the precise structural location of each N-glycan site, but the structural consequences of individual N-glycan site on integrin activation remain unclear. By site-directed mutagenesis and structure-guided analyses, we dissected the function of individual N-glycan sites in β3 integrin activation...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676097/genetic-diversity-of-plasmodium-falciparum-populations-in-southeast-and-western-myanmar
#10
Than Naing Soe, Yanrui Wu, Myo Win Tun, Xin Xu, Yue Hu, Yonghua Ruan, Aung Ye Naung Win, Myat Htut Nyunt, Nan Cho Nwe Mon, Kay Thwe Han, Khin Myo Aye, James Morris, Pincan Su, Zhaoqing Yang, Myat Phone Kyaw, Liwang Cui
BACKGROUND: The genetic diversity of malaria parasites reflects the complexity and size of the parasite populations. This study was designed to explore the genetic diversity of Plasmodium falciparum populations collected from two southeastern areas (Shwekyin and Myawaddy bordering Thailand) and one western area (Kyauktaw bordering Bangladesh) of Myanmar. METHODS: A total of 267 blood samples collected from patients with acute P. falciparum infections during 2009 and 2010 were used for genotyping at the merozoite surface protein 1 (Msp1), Msp2 and glutamate-rich protein (Glurp) loci...
July 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28674488/dancing-or-fitness-sport-the-effects-of-two-training-programs-on-hippocampal-plasticity-and-balance-abilities-in-healthy-seniors
#11
Kathrin Rehfeld, Patrick Müller, Norman Aye, Marlen Schmicker, Milos Dordevic, Jörn Kaufmann, Anita Hökelmann, Notger G Müller
Age-related degenerations in brain structure are associated with balance disturbances and cognitive impairment. However, neuroplasticity is known to be preserved throughout lifespan and physical training studies with seniors could reveal volume increases in the hippocampus (HC), a region crucial for memory consolidation, learning and navigation in space, which were related to improvements in aerobic fitness. Moreover, a positive correlation between left HC volume and balance performance was observed. Dancing seems a promising intervention for both improving balance and brain structure in the elderly...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28666229/structural-characterization-and-identification-of-cyclic-lipopeptides-produced-by-bacillus-methylotrophicus-dcs1-strain
#12
Nawel Jemil, Angeles Manresa, Francesc Rabanal, Hanen Ben Ayed, Noomen Hmidet, Moncef Nasri
Bacillus methylotrophicus DCS1 strain was isolated from diesel contaminated soil and screened for its ability to produce biosurfactants; it was found effective for the production of surface active molecules. The structural characterization of the isolated lipopeptides was studied by a variety of analytical techniques. The organic extract of DCS1 lipopeptides was fractionated by silica gel column chromatography (60Mesh). Fractions containing lipopeptides were collected and identified by tandem mass spectrometry MALDI-TOF-MS and MALDI-TOF MS(2)...
June 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28664433/factors-influencing-the-outcome-of-magnetic-sphincter-augmentation-for-chronic-gastroesophageal-reflux-disease
#13
Heather F Warren, Lisa M Brown, Matias Mihura, Alexander S Farivar, Ralph W Aye, Brian E Louie
OBJECTIVES: Magnetic sphincter augmentation (MSA) is a surgical treatment option for patients with gastroesophageal reflux disease (GERD). MSA consistently improves quality of life, maintains freedom from PPIs, and objectively controls GERD. However, up to 24% of patients did not achieve these outcomes. We sought to identify factors predicting outcomes after MSA placement with the aim of refining selection criteria. METHODS: We retrospectively analyzed clinical, endoscopic, manometric, pH data, and intraoperative factors from two databases: Pivotal Trial (N = 99) and our prospectively maintained esophageal database (N = 71)...
June 29, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28664374/multiple-linear-regression-and-artificial-neural-networks-for-delta-endotoxin-and-protease-yields-modelling-of-bacillus-thuringiensis
#14
Karim Ennouri, Rayda Ben Ayed, Mohamed Ali Triki, Ennio Ottaviani, Maura Mazzarello, Fathi Hertelli, Nabil Zouari
The aim of the present work was to develop a model that supplies accurate predictions of the yields of delta-endotoxins and proteases produced by B. thuringiensis var. kurstaki HD-1. Using available medium ingredients as variables, a mathematical method, based on Plackett-Burman design (PB), was employed to analyze and compare data generated by the Bootstrap method and processed by multiple linear regressions (MLR) and artificial neural networks (ANN) including multilayer perceptron (MLP) and radial basis function (RBF) models...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28661731/at-last-aye-and-there-s-the-rub
#15
Alexander M Capron
Mea culpa. In 1981 the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, of which I was the Executive Director, recommended to the President and Congress that all federal departments and agencies that conduct or support human subjects research adopt "as a common core" the HHS regulations, "while permitting additions needed by any department or agency that are not inconsistent with these core provisions." The commission believed-rightly, I still think-that having uniformity would ease administration, reduce regulatory burdens, simplify oversight, and make research more efficient...
July 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28659164/antioxidant-properties-antimicrobial-and-anti-adhesive-activities-of-dcs1-lipopeptides-from-bacillus-methylotrophicus-dcs1
#16
Nawel Jemil, Hanen Ben Ayed, Angeles Manresa, Moncef Nasri, Noomen Hmidet
BACKGROUND: The present work aims to investigate the antioxidant and antimicrobial activities as well as the potential of DCS1 lipopeptides produced by Bacillus methylotrophicus DCS1 strain at inhibition and disruption of biofilm formation. RESULTS: The produced biosurfactants were characterized as lipopeptides molecules by using thin layer chromatography (TLC) and Fourier transform infrared spectroscopy (FT-IR). The DCS1 lipopeptides were assayed for their antioxidant activity through five different tests...
June 28, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28656557/distribution-and-assessment-of-heavy-metal-toxicity-in-sediment-cores-from-bizerte-lagoon-tunisia
#17
Haïfa Ben Mna, Walid Oueslati, Mohamed Amine Helali, Noureddine Zaaboub, Ayed Added, Lotfi Aleya
To examine the state of pollution of Bizerte Lagoon which is exposed to intense anthropogenic pressure, two sediment cores were taken at two sites, one undergoes the dual effects of both marine waters arriving from the Mediterranean Sea through the Channel, and also of freshwater from the Tinja River; the other core is located at the center of the lagoon where water depth is maximal (12 m). Heavy metal concentrations in the two cores were assessed, with calculated enrichment factors and geo-accumulation indexes...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28648380/privileged-electrophile-sensors-a-resource-for-covalent-drug-development
#18
REVIEW
Marcus John Curtis Long, Yimon Aye
This Perspective delineates how redox signaling affects the activity of specific enzyme isoforms and how this property may be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have extolled the general virtues of developing irreversible inhibitors. Indeed, many modern pharmaceuticals contain electrophilic appendages. Several invoke a warhead that hijacks active-site nucleophiles whereas others take advantage of spectator nucleophilic side chains that do not participate in enzymatic chemistry, but are poised to bind/react with electrophiles...
July 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28640929/modulation-of-tumor-microenvironment-by-chemopreventive-natural-products
#19
REVIEW
Sin-Aye Park, Young-Joon Surh
The tumor microenvironment provides a niche in which cancer cells and their surrounding stromal cells reside and in which their interactions occur. The cross talk between cancer and stromal cells in the tumor microenvironment promotes many biological processes to support cancer cell growth, invasion, angiogenesis, and metastasis. Recently, not only cancer cells but also multiple types of surrounding stromal cells, including endothelial cells, immune cells, and fibroblasts in the tumor microenvironment, have been recognized to be attractive targets for reducing resistance to anticancer therapy and tumor recurrence...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28640911/evolution-of-microrna-in-primates
#20
Jennifer C McCreight, Sean E Schneider, Damien B Wilburn, Willie J Swanson
MicroRNA play an important role in post-transcriptional regulation of most transcripts in the human genome, but their evolution across the primate lineage is largely uncharacterized. A particular miRNA can have one to thousands of messenger RNA targets, establishing the potential for a small change in sequence or overall miRNA structure to have profound phenotypic effects. However, the majority of non-human primate miRNA is predicted solely by homology to the human genome and lacks experimental validation. In the present study, we sequenced thirteen species representing a wide range of the primate phylogeny...
2017: PloS One
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