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https://www.readbyqxmd.com/read/28640929/modulation-of-tumor-microenvironment-by-chemopreventive-natural-products
#1
REVIEW
Sin-Aye Park, Young-Joon Surh
The tumor microenvironment provides a niche in which cancer cells and their surrounding stromal cells reside and in which their interactions occur. The cross talk between cancer and stromal cells in the tumor microenvironment promotes many biological processes to support cancer cell growth, invasion, angiogenesis, and metastasis. Recently, not only cancer cells but also multiple types of surrounding stromal cells, including endothelial cells, immune cells, and fibroblasts in the tumor microenvironment, have been recognized to be attractive targets for reducing resistance to anticancer therapy and tumor recurrence...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28640911/evolution-of-microrna-in-primates
#2
Jennifer C McCreight, Sean E Schneider, Damien B Wilburn, Willie J Swanson
MicroRNA play an important role in post-transcriptional regulation of most transcripts in the human genome, but their evolution across the primate lineage is largely uncharacterized. A particular miRNA can have one to thousands of messenger RNA targets, establishing the potential for a small change in sequence or overall miRNA structure to have profound phenotypic effects. However, the majority of non-human primate miRNA is predicted solely by homology to the human genome and lacks experimental validation. In the present study, we sequenced thirteen species representing a wide range of the primate phylogeny...
2017: PloS One
https://www.readbyqxmd.com/read/28629680/preoperative-embolization-in-spinal-tumour-surgery-enhancing-its-effectiveness
#3
Barry Wei Loong Tan, Aye Sandar Zaw, Prapul Chander Rajendran, John Nathaniel Ruiz, Naresh Kumar, Gopinathan Anil
We conducted a retrospective review of 221 patients, who underwent spinal oncologic surgery at a tertiary university hospital between 2005 and 2014; in order to identify and validate factors that influence the impact of preoperative embolization of spinal tumours on outcome measures of blood loss and transfusion requirements in spinal oncologic surgery. We also focused on primary tumour type and type of spinal surgery performed. Patients' electronic and physical records were reviewed to provide demographic data, tumour characteristics, embolization techniques and surgical procedure details...
June 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28604588/docosahexaenoic-acid-induces-expression-of-heme-oxygenase-1-and-nad-p-h-quinone-oxidoreductase-through-activation-of-nrf2-in-human-mammary-epithelial-cells
#4
Hye-Yoon Bang, Sin-Aye Park, Soma Saeidi, Hye-Kyung Na, Young-Joon Surh
Docosahexaenoic acid (DHA), an ω-3 fatty acid abundant in fish oils, has diverse health beneficial effects, such as anti-oxidative, anti-inflammatory, neuroprotective, and chemopreventive activities. In this study, we found that DHA induced expression of two representative antioxidant/cytoprotective enzymes, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase (NQO1), in human mammary epithealial (MCF-10A) cells. DHA-induced upregulation of these enzymes was accompanied by enhanced translocation of the redox-sensitive transcription factor Nrf2 into the nucleus and its binding to antioxidant response element...
June 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28597332/comparing-the-use-of-live-trees-and-deadwood-for-larval-foraging-by-aye-ayes-daubentonia-madagascariensis-at-kianjavato-and-torotorofotsy-madagascar
#5
Timothy M Sefczek, Domenico Randimbiharinirina, Brigitte M Raharivololona, Joseph D Rabekianja, Edward E Louis
Aye-aye (Daubentonia madagascariensis) feeding behavior has become synonymous with deadwood foraging. However, deadwood is not always the most frequently used substrate, as some aye-ayes use live trees more often to access invertebrates. We sought to compare the frequency of aye-aye invertebrate foraging in deadwood and live trees to better understand their feeding behaviors. We followed two male aye-ayes at Kianjavato, a heavily disturbed habitat in southeastern Madagascar, from October 2013 to October 2014, and one male and one female aye-aye at Torotorofotsy, a continuous forest in eastern Madagascar, from July 2014 to December 2015...
June 8, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28592862/identification-of-unique-cardiolipin-and-monolysocardiolipin-species-in-acinetobacter-baumannii
#6
Patrizia Lopalco, Julia Stahl, Cosimo Annese, Beate Averhoff, Angela Corcelli
Acidic glycerophospholipids play an important role in determining the resistance of Gram-negative bacteria to stress conditions and antibiotics. Acinetobacter baumannii, an opportunistic human pathogen which is responsible for an increasing number of nosocomial infections, exhibits broad antibiotic resistances. Here lipids of A. baumannii have been analyzed by combined MALDI-TOF/MS and TLC analyses; in addition GC-MS analyses of fatty acid methyl esters released by methanolysis of membrane phospholipids have been performed...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28582990/to-what-extent-does-access-to-improved-sanitation-explain-the-observed-differences-in-infant-mortality-in-africa
#7
Aye M Alemu
BACKGROUND: To my knowledge, there was no systematic study so far that analysed the extent of the impact of improved sanitation on infant mortality in the African context with long years of full-fledged longitudinal data. AIM: The aim of this study was to empirically examine the extent to which improved sanitation explains the observed differences in infant mortality under 5 years of age across African countries. SETTING: The study covered a panel of 33 countries from north, south, east, west and central Africa for the years 1994-2013...
May 29, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28559135/the-nadph-oxidase-atrbohi-plays-a-positive-role-in-drought-stress-response-in-arabidopsis-thaliana
#8
Huan He, Jingwei Yan, Xiaoyun Yu, Yan Liang, Lin Fang, Henrik Vibe Scheller, Aying Zhang
As the major resource of reactive oxygen species (ROS), the NADPH oxidases (Rbohs) have been shown to play an important role in plant cells under normal growth and stress conditions. Although many family members of Rbohs were studied, little is known about the function of RbohI in Arabidopsis thaliana. Here, we report that exogenous ABA application decreases RbohI expression and mannitol significantly increases RbohI expression at transcript level. The RbohI transcripts were strongly detected in dry seeds and roots...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28558237/meeting-proceedings-2017-cornell-university-baker-symposium-quo-vadis-the-boundless-trajectories-of-chemical-biology
#9
Jeremy M Baskin, Yimon Aye
No abstract text is available yet for this article.
May 30, 2017: Biochemistry
https://www.readbyqxmd.com/read/28558191/meeting-proceedings-2017-cornell-university-baker-symposium-quo-vadis-the-boundless-trajectories-of-chemical-biology
#10
Jeremy M Baskin, Yimon Aye
No abstract text is available yet for this article.
May 30, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28553609/choice-of-insulin-in-type-2-diabetes-a-southeast-asian-perspective
#11
Sanjay Kalra, Hong Quang Thai, Chaicharn Deerochanawong, Goh Su-Yen, Mafauzy Mohamed, Tint Swe Latt, Than Than Aye, Zafar Ahmed Latif, Prasad Katulanda, Touch Khun, Sum Satha, Vadsana Vongvandy
Southeast Asia faces a diabetes epidemic, which has created significant challenges for health care. The unique Asian diabetes phenotype, coupled with peculiar lifestyle, diet, and healthcare-seeking behavior, makes it imperative to develop clinical pathways and guidelines which address local needs and requirements. From an insulin-centric viewpoint, the preparations prescribed in such pathways should be effective, safe, well tolerated, nonintrusive, and suitable for the use in multiple clinical situations including initiation and intensification...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28496371/dyschromatosis-symmetrica-hereditaria-with-cutaneous-lupus-erythematosus-and-hyperthyroidism
#12
Fahad Al-Saif, Ahmed Alhumidi, Rama Ayed Alhallaf
Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported. We report the first case of DSH, which is associated with cutaneous lupus erythematosus and hyperthyroidism.
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28487882/identification-of-a-novel-rasd1-somatic-mutation-in-a-usp8-mutated-corticotroph-adenoma
#13
Andrew V Uzilov, Khadeen C Cheesman, Marc Y Fink, Leah C Newman, Chetanya Pandya, Yelena Lalazar, Marco Hefti, Mary Fowkes, Gintaras Deikus, Chun Yee Lau, Aye S Moe, Yayoi Kinoshita, Yumi Kasai, Micol Zweig, Arpeta Gupta, Daniela Starcevic, Milind Mahajan, Eric E Schadt, Kalmon D Post, Michael J Donovan, Robert Sebra, Rong Chen, Eliza B Geer
Cushing's disease (CD) is caused by pituitary corticotroph adenomas that secrete excess adrenocorticotropic hormone (ACTH). In these tumors, somatic mutations in the gene USP8 have been identified as recurrent and pathogenic and are the sole known molecular driver for CD. Although other somatic mutations were reported in these studies, their contribution to the pathogenesis of CD remains unexplored. No molecular drivers have been established for a large proportion of CD cases and tumor heterogeneity has not yet been investigated using genomics methods...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28484716/anatomic-variation-in-morphometry-of-human-coracoid-process-among-asian-population
#14
Manal Fathi, Pike-See Cheah, Umar Ahmad, M Nizlan Nasir, Aye Aye San, Ezamin Abdul Rahim, Paisal Hussin, Rozi Mahmud, Fauziah Othman
Ethnic origin plays an important role in bone morphometry. Studies examining the influence of coracoid process have focused primarily on adults and have not included people from diverse Asian ethnic backgrounds. Our goal was to explore ethnic differences in morphometry of coracoid among Asian population. We performed morphometric measurements of coracoid process on cadaveric shoulders and shoulder CT scans from 118 specimens. The cadaveric sample included Indian (46%), Chinese (27%), and Myanmarese (27%) subjects, while the CT scans sample included Chinese (67%) and Malay (33%) subjects...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28481938/correction-pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#15
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
[This corrects the article DOI: 10.1371/journal.pone.0169448.].
2017: PloS One
https://www.readbyqxmd.com/read/28476150/non-adherence-to-anti-retroviral-therapy-among-hiv-infected-adults-in-mon-state-of-myanmar
#16
Win Lei Aye, Apa Puckpinyo, Karl Peltzer
BACKGROUND: The provision of Anti-Retroviral Therapy (ART) was started in Myanmar in 2005 in collaboration with the National AIDS Program and the private sector. Successful clinical management of HIV-infected patients is subject to optimal adherence. The aim of the study was to determine the prevalence of adherence to ART and identify factors associated with non-adherence to ART among HIV infected adults registered in a private sector setting in Mon State, Myanmar. METHODS: This cross-sectional study was conducted with adults living with HIV receiving ART at an HIV outpatient clinic between April and May 2016...
May 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28470643/complement-component-c3-variant-r102g-and-the-risk-of-neovascular-age-related-macular-degeneration-in-a-tunisian-population
#17
Imen Habibi, Imen Sfar, Fedra Kort, Rim Bouraoui, Ahmed Chebil, Rim Limaiem, Saloua Ayed, Taïeb Ben Abdallah, Leila El Matri, Yousr Gorgi
Purpose To explore the association between the polymorphism (S/F) p.R102G in the complement component 3 (C3) gene and age-related macular degeneration (AMD) in a Tunisian population. Methods The molecular study was performed by polymerase chain reaction using sequence-specific primers (PCR-SSP) in 207 control subjects free of any eye disease (fundus normal) and 145 patients with exudative AMD. The CH50 activity and quantification of C3 and C4 have been made by technical home method and nephelometry, respectively...
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28466379/bayesian-and-phylogenic-approaches-for-studying-relationships-among-table-olive-cultivars
#18
Rayda Ben Ayed, Karim Ennouri, Fathi Ben Amar, Fabienne Moreau, Mohamed Ali Triki, Ahmed Rebai
To enhance table olive tree authentication, relationship, and productivity, we consider the analysis of 18 worldwide table olive cultivars (Olea europaea L.) based on morphological, biological, and physicochemical markers analyzed by bioinformatic and biostatistic tools. Accordingly, we assess the relationships between the studied varieties, on the one hand, and the potential productivity-quantitative parameter links on the other hand. The bioinformatic analysis based on the graphical representation of the matrix of Euclidean distances, the principal components analysis, unweighted pair group method with arithmetic mean, and principal coordinate analysis (PCoA) revealed three major clusters which were not correlated with the geographic origin...
May 2, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28458962/team-approach-helps-patient-survive-high-voltage-electric-burn
#19
Noha Saied, Ahmed Harfoush, Tamer Ayed, Alaa Moustafa, Rania Hassan, Ezz Eldolify, Hany Abdelaziz
A 20-year-old man was subjected to high-voltage electric burn, which was occupational. The patient was admitted to AlGalaa Military Medical Complex almost 2 weeks after the accident had happened. According to Lund and Browder's chart, the patient had a 40% total body surface area burn involving the upper limbs, anterior and posterior trunks, and the left thigh (third- and fourth-degree burns). The aim of this study was to stabilize the patient by conducting lifesaving operations in multiple scheduled sessions, bilateral below-elbow amputations, escharotomies, and excision of affected ribs and cartilages...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28450139/3d-fully-convolutional-networks-for-subcortical-segmentation-in-mri-a-large-scale-study
#20
REVIEW
Jose Dolz, Christian Desrosiers, Ismail Ben Ayed
This study investigates a 3D and fully convolutional neural network (CNN) for subcortical brain structure segmentation in MRI. 3D CNN architectures have been generally avoided due to their computational and memory requirements during inference. We address the problem via small kernels, allowing deeper architectures. We further model both local and global context by embedding intermediate-layer outputs in the final prediction, which encourages consistency between features extracted at different scales and embeds fine-grained information directly in the segmentation process...
April 24, 2017: NeuroImage
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