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https://www.readbyqxmd.com/read/29340209/discovery-of-culex-pipiens-associated-tunisia-virus-a-new-ssrna-virus-representing-a-new-insect-associated-virus-family
#1
Diane Bigot, Célestine M Atyame, Mylène Weill, Fabienne Justy, Elisabeth A Herniou, Philippe Gayral
In the global context of arboviral emergence, deep sequencing unlocks the discovery of new mosquito-borne viruses. Mosquitoes of the species Culex pipiens, C. torrentium, and C. hortensis were sampled from 22 locations worldwide for transcriptomic analyses. A virus discovery pipeline was used to analyze the dataset of 0.7 billion reads comprising 22 individual transcriptomes. Two closely related 6.8 kb viral genomes were identified in C. pipiens and named as Culex pipiens associated tunisia virus (CpATV) strains Ayed and Jedaida...
January 2018: Virus Evolution
https://www.readbyqxmd.com/read/29340045/rip140-and-lcor-expression-in-gastrointestinal-cancers
#2
Mouna Triki, Dorra Ben Ayed-Guerfali, Ines Saguem, Slim Charfi, Lobna Ayedi, Tahia Sellami-Boudawara, Vincent Cavailles, Raja Mokdad-Gargouri
The transcription coregulators RIP140 and LCoR are part of a same complex which controls the activity of various transcription factors and cancer cell proliferation. In this study, we have investigated the expression of these two genes in human colorectal and gastric cancers by immunohistochemistry. In both types of tumors, the levels of RIP140 and LCoR appeared highly correlated. Their expression tended to decrease in colorectal cancer as compared to adjacent normal tissues but was found higher in gastric cancer as compared to normal stomach...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29330958/do-muscles-constrain-skull-shape-evolution-in-strepsirrhines
#3
Anne-Claire Fabre, Jonathan M G Perry, Adam Hartstone-Rose, AuróLien Lowie, Andy Boens, MaÏtena Dumont
Despite great interest and decades of research, the musculoskeletal relationships of the masticatory system in primates are still not fully understood. However, without a clear understanding of the interplay between muscles and bones it remains difficult to understand the functional significance of morphological traits of the skeleton. Here, we aim to study the impacts of the masticatory muscles on the shape of the cranium and the mandible as well as their co-variation in strepsirrhine primates. To do so, we use 3D geometric morphometric approaches to assess the shape of each bone of the skull of 20 species for which muscle data are available in the literature...
February 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29330956/craniomandibular-variation-in-phalangeriform-marsupials-functional-comparisons-with-primates
#4
Elizabeth M St Clair, Nicholas Reback, Jonathan M G Perry
Phalangeriform marsupials have often been compared with primates because of similarity in the range of external morphology, ecological niches, and body size between the two radiations. We explore morphological convergence in the masticatory anatomy of strepsirrhine primates and phalangeriforms, through osteological measurements of the mandible and facial skeleton, and through dissection of the masticatory musculature, presenting new data on the arrangement and proportions of jaw adductors in phalangeriforms...
February 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29329287/isolation-and-complete-genome-analysis-of-neurotropic-dengue-virus-serotype-3-from-the-cerebrospinal-fluid-of-an-encephalitis-patient
#5
Rama Dhenni, Mulya Rahma Karyanti, Nina Dwi Putri, Benediktus Yohan, Frilasita A Yudhaputri, Chairin Nisa Ma'roef, Araniy Fadhilah, Aditya Perkasa, Restuadi Restuadi, Hidayat Trimarsanto, Irawan Mangunatmadja, Jeremy P Ledermann, Ronald Rosenberg, Ann M Powers, Khin Saw Aye Myint, R Tedjo Sasmono
Although neurological manifestations associated with dengue viruses (DENV) infection have been reported, there is very limited information on the genetic characteristics of neurotropic DENV. Here we describe the isolation and complete genome analysis of DENV serotype 3 (DENV-3) from cerebrospinal fluid of an encephalitis paediatric patient in Jakarta, Indonesia. Next-generation sequencing was employed to deduce the complete genome of the neurotropic DENV-3 isolate. Based on complete genome analysis, two unique and nine uncommon amino acid changes in the protein coding region were observed in the virus...
January 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29306333/effectiveness-of-a-novel-long-lasting-pyriproxyfen-larvicide-sumilarv%C3%A2-2mr-against-aedes-mosquitoes-in-schools-in-yangon-myanmar
#6
Sai Zaw Min Oo, Sein Thaung, Yan Naung Maung Maung, Khin Myo Aye, Zar Zar Aung, Hlaing Myat Thu, Kyaw Zin Thant, Noboru Minakawa
BACKGROUND: Mosquito-borne diseases are prevalent in Myanmar, with the number of dengue cases showing a significant increase in recent years. Dengue vectors have developed resistance to insecticides and currently used larvicides show only short-term effectiveness. As a result, an alternative larvicide is urgently needed. The present study evaluated the larvicidal effectiveness of long-lasting pyriproxyfen resin discs (SumiLarv®2MR) against dengue virus vectors in schools in Hlaing Thar Yar Township, Yangon...
January 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29301866/functional-and-clinical-relevance-of-vla-4-cd49d-cd29-in-ibrutinib-treated-chronic-lymphocytic-leukemia
#7
Erika Tissino, Dania Benedetti, Sarah E M Herman, Elisa Ten Hacken, Inhye E Ahn, Kari G Chaffee, Francesca Maria Rossi, Michele Dal Bo, Pietro Bulian, Riccardo Bomben, Elisabeth Bayer, Andrea Härzschel, Julia Christine Gutjahr, Massimiliano Postorino, Enrico Santinelli, Ayed Ayed, Francesco Zaja, Annalisa Chiarenza, Gabriele Pozzato, Alexandre Chigaev, Larry A Sklar, Jan A Burger, Alessandra Ferrajoli, Tait D Shanafelt, Adrian Wiestner, Giovanni Del Poeta, Tanja Nicole Hartmann, Valter Gattei, Antonella Zucchetto
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, which antagonizes B cell receptor (BCR) signals, demonstrates remarkable clinical activity in chronic lymphocytic leukemia (CLL). The lymphocytosis experienced by most patients under ibrutinib has previously been attributed to inhibition of BTK-dependent integrin and chemokine cues operating to retain the tumor cells in nodal compartments. Here, we show that the VLA-4 integrin, as expressed by CD49d-positive CLL, can be inside-out activated upon BCR triggering, thus reinforcing the adhesive capacities of CLL cells...
January 4, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29301679/role-of-wing-color-and-seasonal-changes-in-ambient-temperature-and-solar-irradiation-on-predicted-flight-efficiency-of-the-albatross
#8
M Hassanalian, G Throneberry, M Ali, S Ben Ayed, A Abdelkefi
Drag reduction of the wings of migrating birds is crucial to their flight efficiency. Wing color impacts absorption of solar irradiation which may affect drag but there is little known in this area. To this end, the drag reduction induced by the thermal effect of the wing color of migrating birds with unpowered flight modes is presented in this study. Considering this natural phenomenon in the albatross as an example of migrating birds, and applying an energy balance for this biological system, a thermal analysis is performed on the wings during the summer and winter to obtain different ranges of air density, viscosity, and wing surface temperature brought about from a range of ambient temperatures and climatic conditions seen in different seasons and to study their effects...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29275822/screening-for-fetal-growth-restriction-using-fetal-biometry-combined-with-maternal-biomarkers
#9
REVIEW
Francesca Gaccioli, Irving L M H Aye, Ulla Sovio, D Stephen Charnock-Jones, Gordon C S Smith
Fetal growth restriction is a major determinant of perinatal morbidity and mortality. Screening for fetal growth restriction is a key element of prenatal care but it is recognized to be problematic. Screening using clinical risk assessment and targeting ultrasound to high-risk women is the standard of care in the United States and United Kingdom, but the approach is known to have low sensitivity. Systematic reviews of randomized controlled trials do not demonstrate any benefit from universal ultrasound screening for fetal growth restriction in the third trimester, but the evidence base is not strong...
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29275457/clinical-outcomes-after-keraring-implantation-for-keratoconus-management-in-patients-older-than-40-years-a-retrospective-interventional-cohort-study
#10
Zisis Gatzioufas, Aye Khine, Mohamed Elalfy, Ivo Guber, Cameron McLintock, Francesco Sabatino, Samer Hamada, Damian Lake
BACKGROUND: Intracorneal ring segment implantation is an effective and safe method of visual improvement in patients with keratoconus. The aim of our study was to evaluate the long-term clinical outcomes after Keraring implantation for keratoconus in patients older than 40 years. METHODS: Eleven eyes from 11 patients with keratoconus who underwent femtosecond laser-assisted Keraring implantation for keratoconus were included in this retrospective study. The uncorrected visual acuity (UCVA), corrected visual acuity, keratometric readings, central corneal thickness and thinnest corneal pachymetry were evaluated preoperatively and 6 months after the Keraring implantation...
December 23, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29274701/sentinel-surveillance-for-rotavirus-in-children-5-years-of-age-admitted-for-diarrheal-illness-to-yangon-children-s-hospital-myanmar-2009-2014
#11
Theingi Win Myat, Hlaing Myat Thu, Hlaing Myat Kyaw, Khin Mar Aye, Mo Mo Win, Htin Lin, Thin Thin Shwe, Win Mar, Khin Khin Oo, Kyaw Zin Thant
BACKGROUND: Rotavirus is the leading cause of severe acute gastroenteritis (AGE) in children <5 years of age in Myanmar. The purpose of this analysis is to report from the sentinel surveillance system for rotavirus gastroenteritis (RVGE), which collects information on the epidemiology and circulating genotypes to assess the disease burden and support vaccine introduction in Myanmar. METHODS: Prospective, active surveillance for RVGE-associated hospitalizations was conducted during 2009 -2014 at Yangon Children's Hospital...
December 20, 2017: Vaccine
https://www.readbyqxmd.com/read/29248888/genetics-and-genomics-of-breast-fibroadenomas
#12
REVIEW
Benjamin Nathanael Loke, Nur Diyana Md Nasir, Aye Aye Thike, Jonathan Yu Han Lee, Cheok Soon Lee, Bin Tean Teh, Puay Hoon Tan
Fibroadenomas of the breast are benign fibroepithelial tumours most frequently encountered in women of reproductive age, although they may be diagnosed at any age. The fibroadenoma comprises a proliferation of both stromal and epithelial components. The mechanisms underlying fibroadenoma pathogenesis remain incompletely understood. In the clinical setting, distinguishing cellular fibroadenomas from benign phyllodes tumours is a common diagnostic challenge due to subjective histopathological criteria and interobserver differences...
December 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29246663/secretory-lipase-from-the-human-pathogen-leishmania-major-heterologous-expression-in-the-yeast-pichia-pastoris-and-biochemical-characterization
#13
Saoussen Ben Ayed, Madiha Bou Ali, Aymen Bali, Youssef Gargouri, Dhafer Laouini, Yassine Ben Ali
Leishmaniasis is a parasitic reticuloendotheliosis whose pathogen is a zooflagellate belonging to the genus Leishmania transmitted by the bite of an infected phlebotome. Recently, a unique secretory lipase from the human pathogen Leishmania donovani Ldlip3 has been identified and characterized. This lipase has a high identity with a putative triacylglycerol lipase of Leishmania major (Lmlip2). In the present study, Lmlip2 was expressed in the eukaryotic heterologous expression system Pichia pastoris as tagged enzyme of 308 amino acids...
December 12, 2017: Biochimie
https://www.readbyqxmd.com/read/29239481/the-self-curing-phenomenon-of-schistosome-infection-in-rhesus-macaques-insight-from-in-vitro-studies
#14
Workineh Torben, Adebayo J Molehin, Robert V Blair, Carys Kenway, Faith Shiro, Davis Roslyn, Bayissa Chala, Dereje Gutu, Michael A Kebede, Gul Ahmad, Weidong Zhang, Pyone Aye, Mahesh Mohan, Andrew Lackner, Afzal A Siddiqui
A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs)...
November 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29238486/deep-venous-thrombosis-among-hypertensive-patients-in-king-abdulaziz-university-kau-hospital-jeddah-kingdom-of-saudi-arabia
#15
Omar Ayed Alanazi, Nagah Mohamed Abo El-Fetoh, Nesreen Ali Mohammed, Tariq Mozil Aquab Alanizy, Yasir Wadi Alanazi, Munif Saleh Alanazi, Abdurhman Aiash Alrwaili, Amjad Hamoud Alruwaili, Abdullah Hussain Alanazi, Ahmed Saad Alanazi
Background: Deep venous thrombosis (DVT) is a frequent cardiovascular disorder. It is among the main causes of morbidity and mortality among hospitalized patients and, at the same time, can be easily avoided. Studies clarified that there are a variety of factors which can be significantly associated with the development of DVT in hospitalized patients. Objective: to identify frequency and factors associated with occurrence of DVT among hypertensive patients referred to KAU hospital, Jeddah, Kingdom of Saudi Arabia...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29225774/first-record-of-the-ligia-baudiniana-species-complex-in-the-american-gulf-of-mexico-coastline-as-confirmed-by-morphological-and-molecular-approaches
#16
Carlos A Santamaria, Edgar T Bischoff Iii, Moe Aye, Keith W Phillips, Victoria Overmeyer
Ligia isopods exhibit a constrained morphology that makes identification difficult. In the Greater Caribbean, a convoluted taxonomic history has left the distributional limits of Ligia baudiniana unclear. To date, no confirmed records of this species exist from the American Gulf of Mexico. Herein, we report the presence of L. baudiniana in Sarasota-Manatee Florida, as confirmed by morphological and molecular approaches. This is the first record of this species in the region and a ~300Km extension of its range...
2017: F1000Research
https://www.readbyqxmd.com/read/29224103/sex-differences-and-role-of-estradiol-in-hypoglycemia-associated-counter-regulation
#17
Karen P Briski, Hussain N Alhamami, Ayed Alshamrani, Santosh K Mandal, Manita Shakya, Mostafa H H Ibrahim
Vital nerve cell functions, including maintenance of transmembrane voltage and information transfer, occur at high energy expense. Inadequate provision of the obligate metabolic fuel glucose exposes neurons to risk of dysfunction or injury. Clinical hypoglycemia rarely occurs in nondiabetic individuals but is an unfortunate regular occurrence in patients with type 1 or advanced insulin-treated type 2 diabetes mellitus. Requisite strict glycemic control, involving treatment with insulin, sulfonylureas, or glinides, can cause frequent episodes of iatrogenic hypoglycemia due to defective counter-regulation, including reduced glycemic thresholds and diminished magnitude of motor responses...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29199177/inhibition-of-glycogen-phosphorylase-stimulates-ventromedial-hypothalamic-nucleus-amp-activated-protein-kinase-activity-and-neuronal-nitric-oxide-synthase-protein-expression-in-male-rats
#18
Hussain N Alhamami, Ayed Alshamrani, Karen P Briski
The glucose polymer glycogen is a vital fuel reserve in the brain. The mediobasal hypothalamic energy sensor AMP-activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ-aminobutyric acid; GABA] or stimulate [nitric oxide; steroidogenic factor-1 (SF1)] counter-regulatory outflow. This study investigated whether glycogen-derived fuel supply is a critical screened variable in ventromedial hypothalamic nucleus (VMN) monitoring of neuro-metabolic stability during glucostasis and/or insulin (I)-induced hypoglycemia...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29198862/towards-smart-biocide-free-anti-biofilm-strategies-click-based-synthesis-of-cinnamide-analogues-as-anti-biofilm-compounds-against-marine-bacteria
#19
C Sall, M Ayé, O Bottzeck, A Praud, Y Blache
A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 μM) without toxic effect on bacterial growth even at high concentrations(100 μM).
November 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29198625/transversus-abdominis-plane-block-improves-perioperative-outcome-after-esophagectomy-versus-epidural
#20
Gal Levy, Mark A Cordes, Alexander S Farivar, Ralph W Aye, Brian E Louie
BACKGROUND: Pain control is challenging during esophagectomy. An epidural is commonly used, but the sympathetic blockade can have unintended consequences such as hypotension or delayed return of bowel function. A transversus abdominis plane (TAP) block has the potential to control upper abdominal pain without these adverse consequences. We aimed to compare bilateral TAP blocks with patient-controlled analgesia (PCA) for immediate management after esophagectomy with a cohort using a thoracic (T5 to T8) epidural...
December 1, 2017: Annals of Thoracic Surgery
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