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https://www.readbyqxmd.com/read/29329587/the-effectiveness-of-a-web-2-0-physical-activity-intervention-in-older-adults-a-randomised-controlled-trial
#1
Stephanie J Alley, Gregory S Kolt, Mitch J Duncan, Cristina M Caperchione, Trevor N Savage, Anthony J Maeder, Richard R Rosenkranz, Rhys Tague, Anetta K Van Itallie, W Kerry Mummery, Corneel Vandelanotte
BACKGROUND: Interactive web-based physical activity interventions using Web 2.0 features (e.g., social networking) have the potential to improve engagement and effectiveness compared to static Web 1.0 interventions. However, older adults may engage with Web 2.0 interventions differently than younger adults. The aims of this study were to determine whether an interaction between intervention (Web 2.0 and Web 1.0) and age group (<55y and ≥55y) exists for website usage and to determine whether an interaction between intervention (Web 2...
January 12, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29322220/diabetes-and-pregnancy-national-trends-over-a-15%C3%A2-year-period
#2
Sharon T Mackin, Scott M Nelson, Joannes J Kerssens, Rachael Wood, Sarah Wild, Helen M Colhoun, Graham P Leese, Sam Philip, Robert S Lindsay
AIMS/HYPOTHESIS: We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. METHODS: We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth) between 1 April 1998 and 31 March 2013 (n = 813,921) using the Scottish Morbidity Record (SMR02). Pregnancies to mothers with type 1 (n = 3229) and type 2 (n = 1452) diabetes were identified from the national diabetes database (Scottish Care Information-Diabetes), and perinatal outcomes were compared among women with type 1 diabetes, type 2 diabetes and those without diabetes...
January 11, 2018: Diabetologia
https://www.readbyqxmd.com/read/29320949/absorption-distribution-metabolism-and-excretion-of-an-isocitrate-dehydrogenase-2-inhibitor-enasidenib-in-rats-and-humans
#3
Zeen Tong, Christian Atsriku, Usha Yerramilli, Xiaomin Wang, Yan Li, Josephine Reyes, Bin Fan, Hua Yang, Matthew Hoffmann, Sekhar Surapaneni
1. The absorption, distribution, metabolism and excretion (ADME) of enasidenib were studied following a single oral dose of [14C]enasidenib to rats (10 mg/kg; 100 μCi/kg) and healthy volunteers (100 mg; 318 nCi). 2. Enasidenib was readily absorbed, extensively metabolized and primarily eliminated via the hepatobiliary pathway. Enasidenib-derived radioactivity was widely distributed in rats. Excretion of radioactivity was approximately 95% to 99% of the dose from rats in 168 hours post-dose and 82.4% from human volunteers in 504 hours post-dose...
January 10, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29314570/transubclavian-approach-a-competitive-access-for-transcatheter-aortic-valve-implantation-as-compared-to-transfemoral
#4
Ignacio J Amat-Santos, Paol Rojas, Hipólito Gutiérrez, Silvio Vera, Javier Castrodeza, Javier Tobar, L Renier Goncalves-Ramirez, Manuel Carrasco, Pablo Catala, José A San Román
AIMS: Empirically, transfemoral (TF) approach is the first choice for transcatheter aortic valve implantation (TAVI). We aimed to investigate whether transubclavian (TSc) and TF approaches present comparable major outcomes according to current evidence. METHODS: We systematically searched PubMed, EMBASE, and Cochrane database for studies with symptomatic aortic stenosis patients who underwent TAVI through TF or TSc/axillary access from January/2006 to January/2017...
January 3, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29311358/pediatric-sports-and-recreation-related-eye-injuries-treated-in-us-emergency-departments
#5
Krystin N Miller, Christy L Collins, Thitphalak Chounthirath, Gary A Smith
OBJECTIVES: To investigate the epidemiologic characteristics of sports- and recreation-related eye injuries among children in the United States. METHODS: Data from the National Electronic Injury Surveillance System were analyzed in a retrospective study of children ≤17 years of age treated in US emergency departments for sports- and recreation-related eye injuries from 1990 to 2012. RESULTS: From 1990 through 2012, an estimated 441 800 (95% confidence interval: 378 868-504 733) children were treated in US emergency departments for sports- and recreation-related eye injuries, averaging 26...
January 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29302751/primary-fecal-diversion-and-bowel-dysfunction-in-restorative-proctocolectomy-for-ulcerative-colitis-a-nationwide-cross-sectional-study
#6
Anders Mark-Christensen, Søren Brandsborg, Søren Laurberg
PURPOSE: The aim of this study was to explore the effects of primary fecal diversion on the risk of pouch dysfunction. METHODS: Patients operated with an ileal pouch-anal anastomosis in Denmark in 2000-2010 were identified and validated bowel function questionnaires retrieved from a cross-sectional study. Multivariate logistic regression analysis was performed to determine the effect of primary fecal diversion on pouch dysfunction. A diagnostic or procedural code for intraabdominal abscesses and fistulas, occurring within 1 year after pouch creation, and anastomotic leakage or extremely early-onset pouchitis within 30 days of surgery defined a pelvic complication...
January 4, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29301582/association-of-polymorphisms-in-lepr-with-type-2-diabetes-and-related-metabolic-traits-in-a-chinese-population
#7
Lulu Zhang, Yingfen Qin, Danyan Liang, Li Li, Yaojie Liang, Lulin Chen, Lei Tong, Jia Zhou, Hong Li, Haiying Zhang
BACKGROUND: Leptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its related metabolic traits. METHODS: We performed a case-control study to investigate the association of polymorphisms in LEPR with T2DM and related metabolic traits in a Chinese population, with a total of 922 T2DM patients and 1031 nondiabetic subjects...
January 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29298634/school-based-nutrition-education-intervention-using-social-cognitive-theory-for-overweight-and-obese-iranian-adolescent-girls-a-cluster-randomized-controlled-trial
#8
Mohammad Bagherniya, Manoj Sharma, Firoozeh Mostafavi Darani, Mohammad Reza Maracy, Mohammad Safarian, Ramesh Allipour Birgani, Vida Bitarafan, Seyed Ali Keshavarz
Background Nowadays childhood obesity has become one the most challenging issue which is considered as a principle public health problem all around the world. This study was conducted with the aim of evaluating the impact of a 7-month school-based nutrition education intervention using social cognitive theory (SCT) to prevent obesity among overweight and obese adolescent girls. Method In this cluster randomized community trial after choosing schools, a total of 172 overweight and obese girl students participated in the study (87 in the intervention and 85 in the control group)...
January 1, 2018: International Quarterly of Community Health Education
https://www.readbyqxmd.com/read/29297859/trends-in-thyroid-cancer-incidence-and-mortality-in-central-serbia-1999-2014
#9
Miodrag Stojanović, Dijana Stojanović, Nataša Rančić, Aleksandra Ignjatović, Zorica Antic, Snezana Miljkovic, Tatjana Rajovic
INTRODUCTION: Thyroid cancer (TC) is the most common malignant disease of the endocrine system. The incidence of the TC has been increasing worldwide, especially in female population. However, mortality from TC is low in both males and females. The objective of the paper was to determine and to analyze incidence and mortality trends of TC in males and females in the central Serbia in the period 1999-2014. METHOD: In this descriptive study data from the Serbian Cancer Registry were used...
October 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29295752/adherence-to-follow-up-in-high-risk-adenoma-patients-diagnosed-by-and-excluded-from-the-barcelona-colorectal-cancer-screening-programme
#10
Isabel Otero, Andrea Burón, Francesc Macià, Cristina Álvarez-Urturi, Mercè Comas, Marta Román, Xavier Castells
INTRODUCTION: Colorectal cancer screening programmes have been shown to reduce incidence and mortality. High-risk adenomas (HRA) are the most frequently diagnosed lesions in these programmes, and these patients are referred to a specialist. However, few studies have evaluated the adherence of HRA patients to the recommended endoscopic follow-up. OBJECTIVES: To analyse follow-up adherence and duration in patients diagnosed with HRA in a screening programme. METHODS: Retrospective cohort study of patients diagnosed with HRA within one of the participating hospitals of the colorectal cancer screening programme of Barcelona, during the first round of the programme (2010-2011)...
December 30, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29294711/distinct-and-overlapping-correlates-of-psychological-and-physical-partner-violence-perpetration
#11
Michele Cascardi, Ernest N Jouriles, Jeff R Temple
Despite its high prevalence, adverse impact, and potential significance in understanding the onset of physical partner violence (PV), there has been surprisingly scant research on psychological PV perpetration. The present research, guided by social learning and attachment theories, addresses this gap in the literature by examining overlapping and distinct correlates for psychological and physical PV perpetration in emerging adults. Undergraduates ( N = 504) with current or recent dating experience were recruited to complete a self-report survey...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288911/a-retrospective-multicentre-study-of-perampanel-given-as-monotherapy-in-routine-clinical-care-in-people-with-epilepsy
#12
Antonio Gil-Nagel, Sergey Burd, Manuel Toledo, Josemir W Sander, Anna Lebedeva, Anna Patten, Antonio Laurenza
PURPOSE: Perampanel is approved for adjunctive treatment of focal seizures, with or without secondarily generalised seizures, and for primary generalised tonic-clonic seizures in people with epilepsy aged ≥12 years. Perampanel was recently approved for monotherapy use for partial seizures in the United States. This study provides insight into the feasibility of perampanel monotherapy in real-world settings. METHODS: This retrospective, non-interventional, multicentre study (NCT02736162) was conducted between January 2013 and March 2016 in specialist epilepsy centres in Europe and Russia...
October 18, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29285196/identification-of-key-mirna-gene-pairs-in-chronic-lymphocytic-leukemia-through-integrated-analysis-of-mrna-and-mirna-microarray
#13
Jie Li, Yi Qin, Haiyan Zhang
The aim of the present study was to explore the miRNA-Gene regulatory mechanism in chronic lymphocytic leukemia (CLL), and identify new targets for the therapy of CLL. The miRNA expression dataset GSE62137 and mRNA expression dataset GSE22529 were downloaded from National Center of Biotechnology Information Gene Expression Omnibus database. In CLL samples compared with normal B cell samples, differentially expressed miRNAs (DEMs) were identified via the GEO2R instrument of GEO and differentially expressed genes (DEGs) were obtained via the limma package of R...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29285066/hyperthermia-exposure-induces-apoptosis-and-inhibits-proliferation-in-hct116-cells-by-upregulating-mir-34a-and-causing-transcriptional-activation-of-p53
#14
Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xiong
Hyperthermia, as an anticancer therapeutic strategy, presents notable advantages in conjunction with irradiation and/or chemotherapy in the treatment of cancer by promoting apoptosis and inhibiting proliferation. A number of studies have documented that hyperthermia inhibits cancer progression through transcriptional activation of p53, which promotes cell cycle arrest and apoptosis. However, the underlying molecular mechanisms of hyperthermia-regulated apoptosis and proliferation dependent on p53 remain largely unknown...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283961/injuries-associated-with-police-use-of-force
#15
William P Bozeman, Jason P Stopyra, David A Klinger, Brian P Martin, Derrel D Graham, James C Johnson, Katherine Mahoney-Tesoriero, Sydney J Vail
BACKGROUND: Use of Force [UOF] by police can result in serious injuries and fatalities. The risk of significant injuries associated with different force modalities is poorly defined. We sought to determine the incidence of police UOF and compare the likelihood of significant injury with different force modalities. METHODS: A prospective multicenter observational study of all UOF incidents was conducted via mandatory UOF investigations at three mid-sized police agencies over a two year period...
December 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29282638/efficacy-and-safety-of-lumen-apposing-metal-stents-in-management-of-pancreatic-fluid-collections-are-they-better-than-plastic-stents-a-systematic-review-and-meta-analysis
#16
REVIEW
Tariq Hammad, Muhammad Ali Khan, Yaseen Alastal, Wade Lee, Ali Nawras, Mohammad Kashif Ismail, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic ultrasound (EUS)-guided transmural drainage has been increasingly utilized as a first-line therapeutic modality for drainage of pancreatic fluid collections (PFC). Recently, lumen-apposing metal stents (LAMS) have been utilized for management of PFCs. We conducted a systematic review and meta-analysis to evaluate the cumulative efficacy and safety of LAMS in the management of PFC (primary outcome). We also compared the efficacy and safety of LAMS with multiple plastic stents (MPS) in the management of PFC (secondary outcome)...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29282632/effects-of-cilostazol-and-renin-angiotensin-system-ras-blockers-on-the-renal-disease-progression-of-korean-patients-a-retrospective-cohort-study
#17
Yoojin Noh, Jimin Lee, Sooyoung Shin, Inwhee Park, Soo Kyung Bae, Euichul Oh, Sukhyang Lee
Background Decline in estimated glomerular filtration rate (eGFR) is an important surrogate marker for the assessment of renal function. Addition of a second agent to angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) treatment may improve current therapeutic strategies aimed at suppressing renal disease progression. Objective To determine the effect of cilostazol in combination with ACEI or ARB treatment on the decline in eGFR. Setting A tertiary hospital in Korea. Method In an observational cohort study, we analyzed 5505 patients who were prescribed ACEI or ARB and cilostazol or other antiplatelet agents...
December 27, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29281165/an-intercept-study-to-measure-the-extent-to-which-new-zealand-university-students-pre-game
#18
Benjamin C Riordan, Tamlin S Conner, Jayde A M Flett, Nic Droste, Louise Cody, Kate L Brookie, Jessica K Riordan, Damian Scarf
OBJECTIVE: We aimed to quantify the degree to which students pre-gamed in New Zealand, using self-report and breathalysers. METHODS: A total of 569 New Zealand undergraduate students were interviewed (men = 45.2%; first year = 81.4%) entering three university-run concerts. We asked participants to report how many drinks they had consumed, their self-reported intoxication and the duration of their pre-gaming session. We then recorded participants' Breath Alcohol Concentration (BrAC; µg/L) and the time they arrived at the event...
December 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29281157/serum-neurofilament-light-chain-in-patients-with-acute-cerebrovascular-events
#19
Gian Marco De Marchis, Mira Katan, Christian Barro, Joachim Fladt, Christopher Traenka, David J Seiffge, Lisa Hert, Henrik Gensicke, Giulio Disanto, Raoul Sutter, Nils Peters, Hakan Sarikaya, Barbara Goeggel-Simonetti, Marwan El-Koussy, Stephan Engelter, Philippe A Lyrer, Mirjam Christ-Crain, Marcel Arnold, Jens Kuhle, Leo H Bonati
BACKGROUND AND PURPOSE: Serum Neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and TIA. METHODS: Nested within a prospective cohort study, we compared serum neurofilament light chain levels (sNfL) drawn within 24 hours from symptom onset in patients with AIS or TIA. Patients without MRI on admission were excluded. We assessed if sNfL are associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs TIA, (iii) infarct size on admission diffusion weighted imaging (MR-DWI), and (iv) functional outcome at 3 months...
December 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29279935/association-of-modifiable-risk-factors-in-young-adulthood-with-racial-disparity-in-incident-type-2-diabetes-during-middle-adulthood
#20
COMPARATIVE STUDY
Michael P Bancks, Kiarri Kershaw, April P Carson, Penny Gordon-Larsen, Pamela J Schreiner, Mercedes R Carnethon
Importance: In the United States, black individuals are twice as likely to develop type 2 diabetes compared with white individuals, and these disparities are particularly pronounced in young and middle age. Prior studies have identified differences in traditional risk factors that may be associated with racial disparities in diabetes incidence but have not simultaneously adjusted for risk factors measured across multiple domains (eg, the individual and the environment) and updated over time...
December 26, 2017: JAMA: the Journal of the American Medical Association
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