keyword
MENU ▼
Read by QxMD icon Read
search

504

keyword
https://www.readbyqxmd.com/read/29777446/the-degree-of-hiv-1-amino-acid-variability-is-strictly-related-to-different-disease-progression-rates
#1
Rossana Scutari, Monica Faieta, Roberta D'Arrigo, Lavinia Fabeni, Cristina Mussini, Andrea Cossarizza, Claudio Casoli, Carlo Federico Perno, Valentina Svicher, Claudia Alteri, Stefano Aquaro
The aim of this study is to evaluate the amino acid variability of HIV-1 Gp41, C2-V3, and Nef in a group of patients characterized by different disease progression rates. HIV-1 sequences were collected from 19 Long term non progressor patients (LTNPs), 9 slow progressors (SPs), and 11 rapid progressors (RPs). Phylogenetic trees were estimated by MEGA 6. Differences in amino acid variability among sequences belonging to the 3 groups have been evaluated by amino acid divergence, Shannon entropy analysis, and the number of amino acid mutations (defined as amino acid variations compared with HxB2)...
May 17, 2018: Virus Genes
https://www.readbyqxmd.com/read/29777416/identification-of-genes-involved-in-gonadal-sex-differentiation-and-the-dimorphic-expression-pattern-in-takifugu-rubripes-gonad-at-the-early-stage-of-sex-differentiation
#2
Hongwei Yan, Xufang Shen, Xin Cui, Yumeng Wu, Lianshun Wang, Lei Zhang, Qi Liu, Yusheng Jiang
Quantifying the expression of mRNAs in the gonads at the critical stage of molecular sex differentiation stage might help to clarify the regulatory network during early sex differentiation and provide new information on the role of sex-related genes in gonadal function. In this study, transcriptomic analysis of sex-related genes expression profiles in fugu gonads at 60 and 90 days after hatching (dah) was conducted firstly, and a total of 112,504,991 clean reads, encompassing 28.35 Gb of sequences were retrieved...
May 18, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29776864/putaminal-dopamine-depletion-in-de-novo-parkinson-s-disease-predicts-future-development-of-wearing-off
#3
Su Jin Chung, Yoonju Lee, Jungsu S Oh, Jae Seung Kim, Phil Hyu Lee, Young H Sohn
INTRODUCTION: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson's disease. METHODS: This retrospective cohort study included a total of 342 non-demented patients with de novo Parkinson's disease who underwent dopamine transporter positron emission tomography scans at their initial evaluation and received dopaminergic medications for 24 months or longer. Onset of wearing-off was determined based on patients' medical records at their outpatient clinic visits every 3-6 months...
May 10, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29774932/-pathological-staging-criteria-for-carcinoma-in-the-remnant-stomach-an-exploratory-study
#4
Zhidong Gao, Xuesong Zhao, Kewei Jiang, Bo Wang, Yongbai Li, Yingjiang Ye, Shan Wang
OBJECTIVE: To explore the prognostic value of the tumor-ratio-metastasis (TRM) staging system for carcinoma in the remnant stomach(CRS). METHODS: Clinicopathological data of 91 CRS patients who underwent surgery at Peking University People's Hospital between March 1992 and December 2017 were retrospectively analyzed. According to the ratio of metastatic lymph node to dissected lymph node, the R staging was obtained, and the pN staging was replaced by the R staging to create the TRM staging...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774566/influence-of-sex-and-pregnancy-on-survival-in-patients-admitted-with-heart-failure-data-from-a-prospective-multicenter-registry
#5
Manuel Martínez-Sellés, Pablo Díez-Villanueva, Jesús Álvarez-Gracía, Andreu Ferrero-Gregori, Miquel Vives-Borrás, Fernando Worner, Alfredo Bardají, Juan F Delgado, Rafael Vázquez, José R González-Juanatey, Francisco Fernández-Aviles, Juan Cinca
BACKGROUND: Female sex is an independent predictor of better survival in patients with heart failure but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence in the cardiovascular system. HYPOTHESIS: Sex and previous gestations might have a prognostic impact on one-year mortality in patients admitted with heart failure. METHODS: Observational prospective consecutive multicenter registry of 1831 patients (756 women [41...
May 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29774470/reproducibility-and-predictive-value-of-scoring-stromal-tumour-infiltrating-lymphocytes-in-triple-negative-breast-cancer-a-multi-institutional-study
#6
EDITORIAL
Mark O'Loughlin, Xavier Andreu, Simonetta Bianchi, Ewa Chemielik, Alicia Cordoba, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria P Foschini, Päivi Heikkilä, Janina Kulka, Inta Liepniece-Karele, Peter Regitnig, Angelika Reiner, Ales Ryska, Anna Sapino, Aliaa Shalaby, Elisabeth Specht Stovgaard, Cecily Quinn, Elaine M Walsh, Vicky Zolota, Sharon A Glynn, Grace Callagy
BACKGROUND: Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software, an approach that is easily applied in clinical practice. The association between sTILs and response to anthracycline-taxane NACT was also examined...
May 17, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29771976/skin-disease-prevalence-study-in-schoolchildren-in-rural-c%C3%A3-te-d-ivoire-implications-for-integration-of-neglected-skin-diseases-skin-ntds
#7
Rie Roselyne Yotsu, Kouamé Kouadio, Bamba Vagamon, Konan N'guessan, Amari Jules Akpa, Aubin Yao, Julien Aké, Rigobert Abbet Abbet, Barbine Tchamba Agbor Agbor, Roger Bedimo, Norihisa Ishii, L Claire Fuller, Roderick Hay, Oriol Mitjà, Henning Drechsler, Kingsley Asiedu
BACKGROUND: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process. METHODS: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa...
May 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29770230/the-influence-of-education-and-apolipoprotein-%C3%AE%C2%B5-4-on-mortality-in-community-dwelling-elderly-men-and-women
#8
Duke Appiah, Richard N Baumgartner
We investigated the risk of death in relation to the apolipoprotein ε 4 allele and evaluated how it interacts with education in 504 elderly adults (mean age 73 years, 65.3% women) who were enrolled in 1993 into the New Mexico Aging Process Study. During 9 years of follow-up, apolipoprotein ε 2 appeared to be associated with a lower risk for all-cause mortality (hazard ratio (HR) = 0.73, 95% confidence interval (CI): 0.30-1.71) compared to apolipoprotein ε 3 carriers in models adjusted for age, sociodemographic variables, medical conditions, adiposity, and lifestyle factors...
2018: Journal of Aging Research
https://www.readbyqxmd.com/read/29769711/author-correction-evidence-for-a-fe-3-rich-pyrolitic-lower-mantle-from-al-fe-bearing-bridgmanite-elasticity-data
#9
A Kurnosov, H Marquardt, D J Frost, T Boffa Ballaran, L Ziberna
In Extended Data Table 1 of this Letter, some of the elastic constants were reported incorrectly. This occurred as a result of an error in the script used to generate the numbers. The values of the elastic constants at room pressure cited in the manuscript on page 544 were derived using the same erroneous script, and the correct values and 1σ-uncertainties in the last given digit are C11 = 461.3(17) GPa instead of 462.7(17) GPa; C22 = 509.7(26) GPa instead of 504.9(26) GPa; C33 = 425.7(5) GPa instead of 426...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769070/serum-magnesium-levels-and-risk-of-coronary-artery-disease-mendelian-randomisation-study
#10
Susanna C Larsson, Stephen Burgess, Karl Michaëlsson
BACKGROUND: Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary artery disease (CAD). METHODS: This Mendelian randomisation analysis is based on summary-level data from the CARDIoGRAMplusC4D consortium's 1000 Genomes-based genome-wide association meta-analysis of 48 studies with a total of 60,801 CAD cases and 123,504 non-cases...
May 17, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29768529/cross-cultural-psychometric-assessment-of-an-appetite-questionnaire-for-patients-with-cancer
#11
Maria Claudia Bernardes Spexoto, Sergio Vicente Serrano, Vanessa Halliday, João Maroco, Andrew Wilcock, Juliana Alvares Duarte Bonini Campos
OBJECTIVE: To evaluate the psychometric properties, along with cross-cultural invariance analysis, of the Cancer Appetite and Symptom Questionnaire (CASQ). METHOD: Data from 555 United Kingdom (UK) cancer patients were used to evaluate the psychometric properties of the CASQ. Construct validity was assessed through factorial and convergent validity. We conducted a confirmatory factor analysis using as indices the chi-square ratio by degrees of freedom (χ2/df), the comparative fit index (CFI), the goodness of fit index (GFI), and the root mean square error of approximation (RMSEA)...
May 14, 2018: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/29768222/green-synthesis-of-silver-nanoparticles-using-flower-extract-of-malva-sylvestris-and-investigation-of-their-antibacterial-activity
#12
Hassan Mahmoodi Esfanddarani, Abolghasem Abbasi Kajani, Abdol-Khalegh Bordbar
High-quality colloidal silver nanoparticles (AgNP) were synthesised via a green approach by using hydroalcoholic extracts of Malva sylvestris . Silver nitrate was used as a substrate ion while the plant extract successfully played the role of reducing and stabilising agents. The synthesised nanoparticles were carefully characterised by using transmission electron microscopy, atomic-force microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and UV-vis spectroscopy. The maximum absorption wavelengths of the colloidal solutions synthesised using 70 and 96% ethanol and 100% methanol, as extraction solvents, were 430, 485 and 504 nm, respectively...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29765930/effect-of-fennel-on-the-health-status-of-menopausal-women-a-systematic-and-meta-analysis
#13
Talat Khadivzadeh, Mona Najaf Najafi, Leila Kargarfard, Masumeh Ghazanfarpour, Fatemeh Rajab Dizavandi, Imaneh Khorsand
Objectives: The aim of the present study is the systematic and critical investigation of the effectiveness of fennel on the climacteric symptoms among menopausal females. Methods: A search of the trials studying the effect of fennel on menopausal females was conducted in 2017 using the MEDLINE and Scopus databases and the Cochrane Library with the following keywords: fennel, Foeniculum vulgare , and menopause. Results: Fennel combined with officinalis is more effective in the attenuating of sleep disorders compared to Citalopram...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29765762/tris-2-2-6-6-tetra-methyl-8-tri-methyl-sil-yl-benzo-1-2-d-4-5-d-bis-1-3-di-thiol-4-yl-methanol-diethyl-ether-monosolvate
#14
Nico Fleck, Gregor Schnakenburg, Alexander C Filippou, Olav Schiemann
The title compound, a tri-aryl-methanol, C46 H64 OS12 Si3 1 , was synthesized via li-thia-tion of tris-2,2,6,6-tetra-methyl-benzo[1,2- d ;4,5- d ']bis-[1,3]di-thiol-4-yl-methanol, 2 , and electrophilic quenching with tri-methyl-silyl chloride. The current crystal structure reveals information about the reactivity of this compound and compares well with the structure reported for the unsubstituted parent compound 2 [Driesschaert et al. (2012 ▸). Eur. J. Org. Chem. 33 , 6517-6525]. The title compound 1 forms mol-ecular propellers and crystallizes in P [Formula: see text], featuring an unusually long Si-Car bond of 1...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29764414/patient-awareness-knowledge-towards-oral-cancer-a-cross-sectional-survey
#15
Neel Shimpi, Monica Jethwani, Aditi Bharatkumar, Po-Huang Chyou, Ingrid Glurich, Amit Acharya
BACKGROUND: Oral cancer (OC) is associated with multiple risk factors and high mortality rates and substantially contributes to the global cancer burden despite being highly preventable. This cross-sectional study sought to assess current knowledge, awareness, and behaviors of patients in rural communities surrounding OC risk. METHODS: An anonymous 21-question survey was distributed to patients in waiting rooms of a large integrated medical-dental health system serving north-central Wisconsin...
May 15, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29761548/variation-of-carotid-intima-media-thickness-with-body-mass-index-in-healthy-adults-of-black-african-descent
#16
Adesola Abiodun Asaleye, Kolawole Thomas Braimoh, Olalekan Ibukun Oyinloye, Christianah Mopelola Asaleye, Adeleye Dorcas Omisore
OBJECTIVES: Studies have shown that common carotid intima media thickness (CIMT) measured by B-mode sonography increases with body mass index (BMI) among subjects with cardiovascular diseases in different populations. However, association of body fat and subclinical atherosclerosis in the absence of these cardiovascular diseases is understudied. We aimed to evaluate the correlation between BMI and CIMT in a healthy adult population of black African ancestry. METHODS: This is a cross-sectional prospective study in 300 consecutive apparently healthy subjects aged 18 to 70 years without history of hypertension, dyslipidemia, diabetes mellitus, and renal disease...
May 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29761360/tumour-volume-of-resectable-oesophageal-squamous-cell-carcinoma-measured-with-mri-correlates-well-with-t-category-and-lymphatic-metastasis
#17
Lan Wu, Jing Ou, Tian-Wu Chen, Rui Li, Xiao-Ming Zhang, Yan-Li Chen, Yu Jiang, Jian-Qiong Yang, Jin-Ming Cao
OBJECTIVES: To determine association of gross tumour volume (GTV) of resectable oesophageal squamous cell carcinoma (SCC) measured on T2 -weighted imaging (T2 WI), contrast-enhanced T1 -weighted imaging (CE-T1 WI) and diffusion-weighted imaging (DWI) with T category and lymphatic metastasis (LM). METHODS: Sixty oesophageal SCC patients underwent fat-suppressed T2 WI, CE-T1 WI and DWI with b values of 0, 500 and 800 s/mm2 . GTV was measured on three sequences. Statistical analyses were performed to determine association of GTV with T category and LM...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29761223/serum-profile-of-transferrin-isoforms-in-juvenile-idiopathic-arthritis-a-preliminary-study
#18
Ewa Gruszewska, Magdalena Sienkiewicz, Paweł Abramowicz, Jerzy Konstantynowicz, Monika Gudowska-Sawczuk, Lech Chrostek, Bogdan Cylwik
It is reported that alterations in protein glycosylation are present in adult rheumatic diseases; however, the data related to pediatric rheumatic conditions are very scarce. The aim of this study was to assess the effect of juvenile idiopathic arthritis (JIA) on the serum glycosylation profile of transferrin isoforms. Twenty-five patients with different clinical forms of an active JIA and 22 healthy controls were studied. Serum samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France) to determine the levels of transferrin isoforms...
May 14, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29761167/phenotypic-spectrum-and-diagnostic-pitfalls-of-abcb4-deficiency-depending-on-age-of-onset
#19
Stephanie Barbara Schatz, Christoph Jüngst, Verena Keitel-Anselmo, Ralf Kubitz, Christina Becker, Patrick Gerner, Eva-Doreen Pfister, Imeke Goldschmidt, Norman Junge, Daniel Wenning, Stephan Gehring, Stefan Arens, Dirk Bretschneider, Dirk Grothues, Guido Engelmann, Frank Lammert, Ulrich Baumann
Genetic variants in the adenosine triphosphate-binding cassette subfamily B member 4 ( ABCB4 ) gene, which encodes hepatocanalicular phosphatidylcholine floppase, can lead to different phenotypes, such as progressive familial intrahepatic cholestasis (PFIC) type 3, low phospholipid-associated cholelithiasis, and intrahepatic cholestasis of pregnancy. The aim of this multicenter project was to collect information on onset and progression of this entity in different age groups and to assess the relevance of this disease for the differential diagnosis of chronic liver disease...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29758575/-descriptive-analysis-of-health-economics-of-intensive-home-care-of-ventilated-patients
#20
Yvonne Lehmann, Julia Ostermann, Thomas Reinhold, Michael Ewers
INTRODUCTION: Long-term ventilated patients in Germany receive intensive care mainly in the patients' home or in assisted-living facilities. There is a lack of knowledge about the nature and extent of resource use and costs associated with care of this small, heterogeneous but overall growing patient group. METHODS: A sub-study in the context of a research project SHAPE analyzed costs of 29 patients descriptively from a social perspective. Direct and indirect costs of intensive home care over a period of three months were recorded and analyzed retrospectively...
May 14, 2018: Das Gesundheitswesen
keyword
keyword
10156
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"