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https://www.readbyqxmd.com/read/29223089/river-water-infiltration-enhances-denitrification-efficiency-in-riparian-groundwater
#1
Nico Trauth, Andreas Musolff, Kay Knöller, Ute S Kaden, Toralf Keller, Ulrike Werban, Jan H Fleckenstein
Nitrate contamination in ground- and surface water is a persistent problem in countries with intense agriculture. The transition zone between rivers and their riparian aquifers, where river water and groundwater interact, may play an important role in mediating nitrate exports, as it can facilitate intensive denitrification, which permanently removes nitrate from the aquatic system. However, the in-situ factors controlling riparian denitrification are not fully understood, as they are often strongly linked and their effects superimpose each other...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29223057/the-ground-and-low-lying-excited-states-and-feasibility-of-laser-cooling-for-gah-and-inh-cations
#2
Qing-Qing Zhang, Chuan-Lu Yang, Mei-Shan Wang, Xiao-Guang Ma, Wen-Wang Liu
The potential energy curves and transition dipole moments of 12Σ+ and 12Π states of GaH+ and InH+ cations are performed by employing ab initio calculations. Based on the potential energy curves, the rotational and vibrational energy levels of the two states are obtained by solving the Schrödinger equation of nuclear movement. The spectroscopic parameters are deduced with the obtained rovibrational energy levels. The spin-orbit coupling effect of the 2Π states for both the GaH+ and InH+ cations are also calculated...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29223053/pressure-induced-phase-transition-and-fracture-in-%C3%AE-moo3-nanoribbons
#3
Jose V Silveira, Luciana L Vieira, Acrisio L Aguiar, Paulo T C Freire, Josue Mendes Filho, Oswaldo L Alves, Antonio G Souza Filho
MoO3 nanoribbons were studied under different pressure conditions ranging from 0 to 21GPa at room temperature. The effect of the applied pressure on the spectroscopic and morphologic properties of the MoO3 nanoribbons was investigated by means of Raman spectroscopy and scanning electron microscopy techniques. The pressure dependent Raman spectra of the MoO3 nanoribbons indicate that a structural phase transition occurs at 5GPa from the orthorhombic α-MoO3 phase (Pbnm) to the monoclinic MoO3-II phase (P21/m), which remains stable up to 21GPa...
November 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29223032/dna-replication-and-associated-repair-pathways-are-involved-in-the-mutagenesis-of-methylated-cytosine
#4
Marketa Tomkova, Michael McClellan, Skirmantas Kriaucionis, Benjamin Schuster-Böckler
Transitions of cytosine to thymine in CpG dinucleotides are the most frequent type of mutations observed in cancer. This increased mutability is commonly explained by the presence of 5-methylcytosine (5mC) and its spontaneous hydrolytic deamination into thymine. Here, we describe observations that question whether spontaneous deamination alone causes the elevated mutagenicity of 5mC. Tumours with somatic mutations in DNA mismatch-repair genes or in the proofreading domain of DNA polymerase ε (Pol ε) exhibit more 5mC to T transitions than would be expected, given the kinetics of hydrolytic deamination...
November 24, 2017: DNA Repair
https://www.readbyqxmd.com/read/29223028/accident-rates-and-the-impact-of-daylight-saving-time-transitions
#5
David Robb, Thomas Barnes
One-third of nations have adopted some form of Daylight Saving Time (DST). Associated costs and benefits include impacts on accident rates. Using data from 12.6 million accident claims in New Zealand during 2005-2016, we model accident rates as a function of various date-based predictors including days before/after the start and end of DST, holidays, day of week, and month of year. This is the first study to consider multiple accident categories (Road, Work, Falls and Home & Community), and the first in the southern hemisphere...
December 6, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29223006/the-temple-star-transitional-model-of-care-for-epilepsy-the-outcome-of-a-quality-improvement-project
#6
Suzanne L Crowley, Susan Byrne, Sandra McNulty, Kim Keating, Therese Nestor, Yvonne Owen, Declan O'Rourke, Bryan Lynch, Amre Shahwan, Mary D King
OBJECTIVE: The aim and objective of this study was to assess the knowledge and views of parents on transitional and adolescent care in young adults with epilepsy, and to develop a transitional and adolescent program for epilepsy. METHODS: Data were collected from questionnaires completed by parents during focus groups exploring transitional care and inherent issues for young adults, aged 12-18years, with epilepsy. The questionnaire assessed the current knowledge and views of parents of children with epilepsy on transitional care, and following a presentation on "Transition in Epilepsy" (including themes such as self-advocacy, independent healthcare behavior, sexual health, psychosocial support, educational and vocational planning, health and lifestyle issues) assessed feedback on the proposed model of care in transitional and adolescent care...
December 6, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29223000/bilateral-preictal-signature-of-phase-amplitude-coupling-in-canine-epilepsy
#7
Laura Gagliano, Elie Bou Assi, Dang K Nguyen, Sandy Rihana, Mohamad Sawan
Seizure forecasting would improve the quality of life of patients with refractory epilepsy. Although early findings were optimistic, no single feature has been found capable of individually characterizing brain dynamics during transition to seizure. Cross-frequency phase amplitude coupling has been recently proposed as a precursor of seizure activity. This work evaluates the existence of a statistically significant difference in mean phase amplitude coupling distribution between the preictal and interictal states of seizures in dogs with bilaterally implanted intracranial electrodes...
November 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29222871/myelin-extracellular-leaflet-compaction-requires-apolipoprotein-d-membrane-management-to-optimize-lysosomal-dependent-recycling-and-glycocalyx-removal
#8
Nadia García-Mateo, Raquel Pascua-Maestro, Alberto Pérez-Castellanos, Concepción Lillo, Diego Sanchez, Maria D Ganfornina
To compact the extracellular sides of myelin, an important transition must take place: from membrane sliding, while building the wraps, to membrane adhesion and water exclusion. Removal of the negatively charged glycocalyx becomes the limiting factor in such transition. What is required to initiate this membrane-zipping process? Knocking-out the Lipocalin Apolipoprotein D (ApoD), essential for lysosomal functional integrity in glial cells, results in a specific defect in myelin extracellular leaflet compaction in peripheral and central nervous system, which results in reduced conduction velocity and suboptimal behavioral outputs: motor learning is compromised...
December 9, 2017: Glia
https://www.readbyqxmd.com/read/29222745/mir-26a-functions-as-a-tumor-suppressor-in-ambient-particulate-matter-bound-metal-triggered-lung-cancer-cell-metastasis-by-targeting-lin28b-il6-stat3-axis
#9
Yan-Yang Lu, Yi Lin, Dong-Xiao Ding, Shu Su, Qiao-Qiao Chi, You-Chi Zhang, Jian Sun, Xu Zhang, Hui-Min Zhu, Qian-Sheng Huang, Yu-Lang Chi, Guo-Zhu Ye, Shu Tao, Si-Jun Dong
Exposure to ambient particulate matter (PM) has been linked to the increasing incidence and mortality of lung cancer, but the principal toxic components and molecular mechanism remain to be further elucidated. In this study, human lung adenocarcinoma A549 cells were treated with serial concentrations of water-extracted PM10 (WE-PM10) collected from Beijing, China. Our results showed that exposure to 25 and 50 μg/ml of WE-PM10 for 48 h significantly suppressed miR-26a to upregulate lin-28 homolog B (LIN28B), and in turn activated interleukin 6 (IL6) and signal transducer and activator of transcription 3 (STAT3) in A549 cells, subsequently contributing to enhanced epithelial-mesenchymal transition and accelerated migration and invasion...
December 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29222714/domperidone-prolongs-oral-to-duodenal-transit-time-in-video-capsule-endoscopy
#10
Michael Mcfarlane, B Liu, C Nwokolo
PURPOSE: Domperidone is thought to accelerate gastric emptying via D2 receptor antagonism at the gastro-oesophageal and gastro-duodenal junctions. Listed in the BNF as a prokinetic anti-emetic, it has been used in video capsule endoscopy (VCE) to accelerate capsule delivery to the small intestine. We audited VCEs performed at UHCW from 2011, when as standard practice, domperidone was given pre-VCE, to 2012, after its discontinuation due to doubts about its effectiveness. METHODS: Thirty-one patients received oral domperidone 20 mg pre-VCE...
December 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29222704/healthcare-system-barriers-to-long-term-follow-up-for-adult-survivors-of-childhood-cancer-in-british-columbia-canada-a-qualitative-study
#11
A Fuchsia Howard, Arminee Kazanjian, Sheila Pritchard, Rob Olson, Haroon Hasan, Kelly Newton, Karen Goddard
PURPOSE: Risk-stratified life-long follow-up care is recommended for adult childhood cancer survivors (CCS) to ensure appropriate prevention, screening, and management of late effects. The identification of barriers to long-term follow-up (LTFU), particularly in varying healthcare service contexts, is essential to develop and refine services that are responsive to survivor needs. We aimed to explore CCS and healthcare professionals (HCP) perspectives of healthcare system factors that function as barriers to LTFU in British Columbia, Canada...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#12
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29222670/venetoclax-for-treating-chronic-lymphocytic-leukaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#13
REVIEW
Hema Mistry, Chidozie Nduka, Martin Connock, Jill Colquitt, Theodoros Mantopoulos, Emma Loveman, Renata Walewska, James Mason
Venetoclax is licensed to treat relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL). As part of the Single Technology Appraisal (STA) ID944, the National Institute for Health and Care Excellence (NICE) invited AbbVie, the manufacturer, to submit evidence on the use of venetoclax, within its licensed indication. The Evidence Review Group (ERG), Warwick Evidence, was asked to provide an independent and critical review of the submitted evidence. Evidence came from three single-arm trials in CLL patients with or without 17p deletion [del(17p])/TP53 chromosomal abnormalities...
December 8, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29222642/pituitary-adenomas-stem-cells-and-cancer-stem-cells-what-s-new
#14
REVIEW
M Caffarini, M Orciani, L Trementino, R Di Primio, G Arnaldi
PURPOSE: To clarify the existence of pituitary stem cells (SCs) both in the embryonic and the postnatal gland and the role for SCs in pituitary adenomas. METHODS: This work, which does not address the pathogenesis of pituitary adenomas, reviews the latest research findings and discoveries on SCs in pituitary and cancer SCs (CSCs) in pituitary adenomas and discusses the involvement of the EMT. RESULTS: Several groups using different approaches and techniques have demonstrated the existence of SCs and CSCs and as they are major players in pituitary adenoma onset...
December 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29222528/structure-and-dynamics-of-cas9-hnh-domain-catalytic-state
#15
Zhicheng Zuo, Jin Liu
The bacterial CRISPR-Cas9 immune system has been harnessed as a powerful and versatile genome-editing tool and holds immense promise for future therapeutic applications. Despite recent advances in understanding Cas9 structures and its functional mechanism, little is known about the catalytic state of the Cas9 HNH nuclease domain, and identifying how the divalent metal ions affect the HNH domain conformational transition remains elusive. A deeper understanding of Cas9 activation and its cleavage mechanism can enable further optimization of Cas9-based genome-editing specificity and efficiency...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222513/biotrophy-necrotrophy-switch-in-pathogen-evoke-differential-response-in-resistant-and-susceptible-sesame-involving-multiple-signaling-pathways-at-different-phases
#16
Supriyo Chowdhury, Arpita Basu, Surekha Kundu
Infection stages of charcoal rot fungus Macrophomina phaseolina in sesame revealed for the first time a transition from biotrophy via BNS (biotrophy-to-necrotrophy switch) to necrotrophy as confirmed by transcriptional studies. Microscopy using normal and GFP-expressing pathogen showed typical constricted thick intercellular bitrophic hyphae which gave rise to thin intracellular necrotrophic hyphae during BNS and this stage was delayed in a resistant host. Results also show that as the pathogen switched its strategy of infection, the host tailored its defense strategy to meet the changing situation...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222494/the-consequences-of-replacing-wildlife-with-livestock-in-africa
#17
Gareth P Hempson, Sally Archibald, William J Bond
The extirpation of native wildlife species and widespread establishment of livestock farming has dramatically distorted large mammal herbivore communities across the globe. Ecological theory suggests that these shifts in the form and the intensity of herbivory have had substantial impacts on a range of ecosystem processes, but for most ecosystems it is impossible to quantify these changes accurately. We address these challenges using species-level biomass data from sub-Saharan Africa for both present day and reconstructed historical herbivore communities...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222478/viscosity-jump-in-the-lower-mantle-inferred-from-melting-curves-of-ferropericlase
#18
Jie Deng, Kanani K M Lee
Convection provides the mechanism behind plate tectonics, which allows oceanic lithosphere to be subducted into the mantle as "slabs" and new rock to be generated by volcanism. Stagnation of subducting slabs and deflection of rising plumes in Earth's shallow lower mantle have been suggested to result from a viscosity increase at those depths. However, the mechanism for this increase remains elusive. Here, we examine the melting behavior in the MgO-FeO binary system at high pressures using the laser-heated diamond-anvil cell and show that the liquidus and solidus of (Mg x Fe1-x )O ferropericlase (x = ~0...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222475/suitability-of-various-chromatographic-and-spectroscopic-techniques-for-analysis-and-kinetic-degradation-study-of-trelagliptin
#19
Wafaa A Zaghary, Shereen Mowaka, Mostafa A Hassan, Bassam M Ayoub
Multifaceted comparative analytical methods for trelagliptin (TRL) were investigated, applied to ZAFATEK tablets and HPLC-UV was selected for a degradation kinetic study. UPLC-MS/MS (Method I), UPLC-UV (Method II), HPLC-UV (Method III), UHPLC-UV (Method IV) and direct UV (Method V) methods were developed. Methods (I-V) showed satisfactory results using TRL concentration ranges of 50-800 ng/mL, 2.5-80 μg/mL, 5-100 μg/mL, 5-100 μg/mL and 5-50 μg/mL, respectively. Multiple Reaction Monitoring (MRM) of the transition pairs of m/z 358...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222459/uncovering-heterogeneous-interactions-in-online-commercial-networks
#20
Fangfeng Zhang, An Zeng, Bowen Ma, Ying Fan, Zengru Di
With the rapid development of Internet, the research on online commercial networks has become crucial for filtering out irrelevant information for users and predicting their future interest. The common methods for understanding such typical user-item networks are mainly projecting them to unipartite ones with only positive ratings, which may result in losing a large amount of information. In this paper, we propose a novel approach to construct a signed unipartite network with heterogeneous interactions (i.e...
December 8, 2017: Scientific Reports
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