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https://www.readbyqxmd.com/read/29050413/laying-hens-in-aviaries-with-different-litter-substrates-behavior-across-the-flock-cycle-and-feather-lipid-content
#1
D L M Campbell, A B A Ali, D M Karcher, J M Siegford
The tiered aviary for laying hens includes a floor litter area to promote foraging and dust bathing. Data are needed on hens' use of different litter substrates and effectiveness of substrates in removing excess feather lipids to ensure a suitable litter area. Bovans White hens were housed in commercial-style aviaries with access to one of 3 litter substrates (wood shavings, straw, or plastic turf mats-AstroTurf®, n = 4 aviary pens per substrate, 144 cage-reared hens populated per pen). Litter areas were videoed across 2 d each at 4 ages: immediately following first aviary opening (25 wk), then at 28, 50, and 68 weeks...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050342/role-of-the-cyp3a4-mediated-11-12-epoxyeicosatrienoic-acid-pathway-in-the-development-of-tamoxifen-resistant-breast-cancer
#2
Nguyen Thi Thuy Phuong, Ji Won Kim, Jung-Ae Kim, Jang Su Jeon, Ji-Yoon Lee, Wen Jun Xu, Jin Won Yang, Sang Kyum Kim, Keon Wook Kang
Epoxyeicosatrienoic acid (EET) production via cytochrome P450 (CYP) epoxygenases closely correlates with the progression of breast cancer. However, its role in the development of chemoresistant breast cancers has yet to be elucidated. Here, we found that CYP3A4 expression and its epoxy-product, 11,12-epoxyeicosatrienoic acid (11,12-EET) was enhanced in tamoxifen (TAM)-resistant MCF-7 (TAMR-MCF-7) breast cancer cells compared to control MCF-7 cells. Treatment of TAMR-MCF-7 cells with ketoconazole and azamulin (selective CYP3A4 inhibitors) or 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE, an EET antagonist) inhibited cellular proliferation and recovered the sensitivity to 4-hydroxytamoxifen...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050340/nogo-b-promotes-emt-in-lung-fibrosis-via-mmp14-mediates-free-tgf-beta1-formation
#3
Ye Xiong, Jing Zhang, Lingzhi Shi, Yunye Ning, Ying Zhu, Si Chen, Meng Yang, Jingyu Chen, Guo-Wu Zhou, Qiang Li
Idiopathic pulmonary fibrosis (IPF) is a lung disease with an extremely poor prognosis. Epithelial mesenchymal transition (EMT) appearing on the airway epithelial cell plays an essential role in the formation and development of Idiopathic pulmonary fibrosis. In this paper, Bleomycin (BLM)-induced mice model combined with bioinformatics analysis were employed to elucidate the potential mechanism of EMT in pulmonary fibrosis. The obtained results showed that endoplasmic reticulum protein Nogo-b may promote MMP14-mediated proprotein maturation of TGF-β1, accelerating the release of free TGF-β1 in type II airway epithelial cells A549, subsquently, induce the epithelial-mesenchymal transition (EMT) of the cell...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050313/adipose-derived-mesenchymal-stem-cells-employed-exosomes-to-attenuate-aki-ckd-transition-through-tubular-epithelial-cell-dependent-sox9-activation
#4
Fengming Zhu, Octavia L S Chong Lee Shin, Guangchang Pei, Zhizhi Hu, Juan Yang, Han Zhu, Meng Wang, Jingyi Mou, Jie Sun, Yuxi Wang, Qian Yang, Zhi Zhao, Huzi Xu, Hui Gao, Weiqi Yao, Xiao Luo, Wenhui Liao, Gang Xu, Rui Zeng, Ying Yao
Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidney disease (CKD), however effective treatments are still elusive. This study aimed to investigate the therapeutic efficacy of human adipose-derived MSCs (hAD-MSCs) in the prevention of AKI-CKD transition, and illuminate the role of Sox9, a vital transcription factor in the development of kidney, in this process. C57BL/6 mice were subjected to unilateral renal ischemia/reperfusion (I/R) with or without hAD-MSC treatment...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050299/exostosin-1-regulates-cancer-cell-stemness-in-doxorubicin-resistant-breast-cancer-cells
#5
Sarala Manandhar, Chang-Gu Kim, Sun-Hee Lee, Soo Hyun Kang, Nikita Basnet, You Mie Lee
Cancer stem cells (CSCs) are associated with cancer recurrence following radio/chemotherapy owing to their high resistance to therapeutic intervention. In this study, we investigated the role of exostoxin 1 (EXT1), an endoplasmic reticulum (ER)-residing type II transmembrane glycoprotein, in cancer cell stemness. DNA microarray analysis revealed that doxorubicin-resistant MCF7/ADR cells have high levels of EXT1 expression compared to its parental cell line, MCF7. These cells showed significantly higher populations of CSCs and larger populations of aldehyde dehydrogenase (ALDH(+)) and CD44(+)/CD24(-)cells, as compared to MCF7 cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050271/sesquiterpene-binding-gly-leu-ser-lys-co-adaptation-pocket-to-inhibit-lung-cancer-cell-epithelial-mesenchymal-transition
#6
Xiao-Yu Ai, Heng Zhang, Shao-Yan Gao, Yuan Qin, Wei-Long Zhong, Ju Gu, Meng Li, Kai-Liang Qiao, Qin Tian, Zhan-Hong Cui, Jia-Huan Yang, Zhun Bi, Ting Xiao, Shuang Chen, Hui-Juan Liu, Hong-Gang Zhou, Tao Sun, Cheng Yang
Sesquiterpene lactones (SL) have a wide range of applications in anti-tumor and anti-inflammatory therapy. However, the pharmacological mechanism of such substances is not clear. In this study, parthenolide (PTL) was used as an example to explore the anti-tumor effect of natural molecules and their common mechanism. We showed that PTL inhibited the proliferation and migration by reverse EMT via the ERK2/NF-κB/Snail pathway in vivo and in vitro. Interestingly, Multiple potential targets of PTL contain a Gly-Leu-Ser/Lys-"co-adaptation pocket"...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050269/long-non-coding-rna-carlo-5-promotes-tumor-progression-in-hepatocellular-carcinoma-via-suppressing-mir-200b-expression
#7
Chunqing Dou, Liyuan Sun, Xin Jin, Mingming Han, Bao Zhang, Xian Jiang, Jinyong Lv, Tao Li
Long non-coding RNAs (lncRNAs) play key roles in cancer initiation and progression. The aim was to investigate the biological functions and clinical significance of long non-coding RNA CARLo-5 in hepatocellular carcinoma (HCC). QRT-PCR was performed to investigate CARLo-5 expression in HCC tissues and cells. Kaplan-Meier curve and multivariate analysis validated the association between CARLo-5 expression and overall survival (OS) in HCC patients. Cell proliferation and invasion was performed by CCK8 cell proliferation, cell colony formation and transwell invasion assays...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050263/the-prognostic-value-of-osteopontin-in-limited-stage-small-cell-lung-cancer-patients-and-its-mechanism
#8
Fanglei Liu, Chunxue Bai, Zhongliang Guo
Osteopontin (OPN) is known to be overexpressed in numerous carcinomas. Although abundant OPN has been reported to be correlated with poor survival in non-small cell lung cancer (NSCLC) but their clinical and prognostic significance in SCLC remains unknown. In this study, RNA-sequencing was used to obtain gene expression data in SCLC tissue samples and OPN expression levels were then investigated using qPCR, immunohistochemical and Western blot. We found OPN was one of the most upregulated genes. Besides, the correlation of OPN with tumor clinicopathological characteristics was evaluated and we found OPN was associated with advanced tumor stages...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050257/linc-ror-induces-epithelial-to-mesenchymal-transition-in-ovarian-cancer-by-increasing-wnt-%C3%AE-catenin-signaling
#9
Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Lingzhi Wang, Xiangyu Wang, Tian Tian
Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) is an intergenic long non-coding RNA (lncRNA) previously shown to contribute to tumorigenesis in several malignancies. However, little is known about whether linc-ROR has a role in ovarian cancer progression. In this study, we found that linc-ROR expression was increased in high-grade ovarian serous cancer tissues compared with normal ovarian tissues or normal fallopian tube tissues. Furthermore, the level of linc-ROR expression was associated with ovarian cancer International Federation of Gynecology and Obstetrics stage and lymph node metastasis...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050223/mir-23a-promotes-tgf-%C3%AE-1-induced-emt-and-tumor-metastasis-in-breast-cancer-cells-by-directly-targeting-cdh1-and-activating-wnt-%C3%AE-catenin-signaling
#10
Fei Ma, Wenjie Li, Chunxiao Liu, Wei Li, Haining Yu, Bo Lei, Yanlv Ren, Zhigao Li, Da Pang, Cheng Qian
TGF-β1-induced epithelial-mesenchymal transition (EMT) has been proved to be associated with metastasis of breast cancer cells. We attempted to detect a novel mechanism that microRNAs mediated the TGF-β1-induced EMT in the process of breast cancer metastasis. Here we reported that the expression of miR-23a was higher in breast cancer cells with high metastasis ability and patients with lymph node metastasis and the treatment of TGF-β1 significantly upregulated the expression of miR-23a in breast cancer cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050211/silibinin-attenuates-radiation-induced-intestinal-fibrosis-and-reverses-epithelial-to-mesenchymal-transition
#11
Joong Sun Kim, Na-Kyung Han, Sung-Ho Kim, Hae-June Lee
Radiotherapy is a common treatment for cancer patients, but its use is often restricted by the tolerance of normal tissue. As cancer patients live longer, delayed radiation effects on normal tissue have become a concern. Radiation-induced enteropathy, including inflammatory bowel disease and fibrosis, are major issues for long-term cancer survivors. To investigate whether silibinin attenuates delayed radiation-induced intestinal injury in mice, we focused on intestinal fibrotic changes. Silibinin improved delayed radiation injuries in mice in association with decreased collagen deposition within the intestines and deceased transforming growth factor (TGF)-β1 levels in the intestine and plasma...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050206/wnt-%C3%AE-catenin-signaling-promotes-aging-associated-hair-graying-in-mice
#12
Zhihui Zhang, Mingxing Lei, Haoran Xin, Chunyan Hu, Tian Yang, Yizhan Xing, Yuhong Li, Haiying Guo, Xiaohua Lian, Fang Deng
Canities is an obvious sign of aging in mouse and human, shown as hair graying. Melanocytes in the hair follicle show cyclic activity with hair cycling, which transitions from anagen, catagen to telogen. How the hairs turn gray during aging is not completely uncovered. Here, by using immunostaining and LacZ staining in Dct-LacZ mice, we show that β-catenin is expressed in melanocytes during hair cycling. RT-PCR, western blot and immunostaining show that β-catenin expression is significantly increased in both anagen and telogen skin of aged mice, when compared to the anagen and telogen skin of young mice, respectively...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049988/magnolia-officinalis-bark-extract-induces-depolarization-of-pacemaker-potentials-through-m2-and-m3-muscarinic-receptors-in-cultured-murine-small-intestine-interstitial-cells-of-cajal
#13
Hyun Jung Kim, Taewon Han, Yun Tai Kim, Insuk So, Byung Joo Kim
BACKGROUND: Magnolia officinalis Rehder and EH Wilson (M. officinalis) are traditional Chinese medicines widely used for gastrointestinal (GI) tract motility disorder in Asian countries. We investigated the effects of an ethanol extract of M. officinalis (MOE) on the pacemaker potentials of cultured interstitial cells of Cajal (ICCs) in vitro and its effects on GI motor functions in vivo. METHODS: We isolated ICCs from small intestines, and the whole-cell patch-clamp configuration was used to record the pacemaker potentials in cultured ICCs in vitro...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049979/triptonide-inhibits-the-pathological-functions-of-gastric-cancer-associated-fibroblasts
#14
Zhenfei Wang, Daguang Ma, Changshan Wang, Zhe Zhu, Yongyan Yang, Fenfang Zeng, Jianlong Yuan, Xia Liu, Yue Gao, Yongxia Chen, Yongfeng Jia
Direct attacks on tumour cells with chemotherapeutic drugs have the drawbacks of accelerating tumour metastasis and inducing tumour stem cell phenotypes. Inhibition of tumour-associated fibroblasts, which provide nourishment and support to tumour cells, is a novel and promising anti-tumour strategy. However, effective drugs against tumour-associated fibroblasts are currently lacking. In the present study, we explored the possibility of inhibiting the pathological functions of tumour-associated fibroblasts with triptonide...
October 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29049883/rotational-spectroscopy-of-p-toluic-acid-and-its-1-1-complex-with-water
#15
Elijah G Schnitzler, Nathan A Seifert, Ignes Kusuma, Wolfgang Jaeger
The structure and internal dynamics of p-toluic acid and its 1:1 complex with water were investigated in the gas phase using chirped-pulse and cavity-based Fourier transform microwave spectroscopy. One conformer and one isomer were identified for the monomer and monohydrate, respectively. In the monohydrate, water acts as both a hydrogen bond donor and acceptor, participating in a six-membered intermolecular ring with the carboxyl group. Both a- and b-type transitions were observed for the monomer; only a-type transitions were observed for the monohydrate...
October 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29049880/crystalline-ordering-and-large-fugacity-expansion-for-hard-core-lattice-particles
#16
Ian Jauslin, Joel L Lebowitz
Using an extension of Pirogov-Sinai theory we prove phase transitions, corresponding to sublattice orderings, for a general class of hard-core lattice particle systems with a finite number of perfect coverings. These include many cases for which such transitions have been proven. The proof also shows that, for these systems, the Gaunt- Fisher expansion of the pressure in powers of the inverse fugacity (aside from an explicit logarithmic term) has a nonzero radius of convergence.
October 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29049878/unifying-exchange-sensitivity-in-transition-metal-spin-state-ordering-and-catalysis-through-bond-valence-metrics
#17
Terry Z H Gani, Heather J Kulik
Accurate predictions of spin-state ordering, reaction energetics and barrier heights are critical for the computational discovery of open-shell transition metal (TM) catalysts. Semilocal approximations in density functional theory, such as the generalized gradient approximation (GGA), suffer from delocalization error that causes them to overstabilize strongly bonded states. Descriptions of energetics and bonding are often improved by introducing a fraction of exact exchange (e.g., erroneous low-spin GGA ground states instead correctly predicted as high-spin with a hybrid functional)...
October 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29049876/rational-design-of-three-dimensional-graphene-encapsulated-with-hollow-fep-carbon-nanocomposite-as-outstanding-anode-material-for-lithium-ion-and-sodium-ion-batteries
#18
Xiujuan Wang, Kai Chen, Gang Wang, Xiaojie Liu, Hui Wang
Transition metal phosphides (TMPs) have been extensively investigated owing to their high theoretical capacities and relatively low intercalation potentials vs. Li/Li+, but their practical applications have been hindered by low electrical conductivity and dramatic volume variation during cycling. In this work, an interesting strategy for rational design of graphene (GR) encapsulated with hollow FeP@carbon nanocomposite (H-FeP@C@GR) via a combination of hydrothermal route, carbon coating process, phosphidation treatment, and carbothermic reaction is reported...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29049871/a-table-top-pxi-based-low-field-spectrometer-for-solution-dynamic-nuclear-polarization
#19
Joshua R Biller, Karl F Stupic, J Moreland
We present the development of a portable dynamic nuclear polarization (DNP) instrument based on the PCI eXtensions for Instrumentation (PXI) platform. The main purpose of the instrument is for study of (1) H polarization enhancements in solution through the Overhauser mechanism at low magnetic fields. A DNP probe set was constructed for use at 6.7 mT, using a modified Alderman-Grant (MAG) resonator at 241 MHz for saturation of the electron transition. The solenoid for detection of the enhanced (1) H signal at 288 kHz was constructed with Litz wire...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049799/neurological-outcome-and-efficacy-of-intensive-craniocervical-screening-for-elective-cardiac-surgery
#20
Ken-Ichi Imasaka, Eiki Tayama, Shigeki Morita, Yukihiro Tomita
OBJECTIVES: To evaluate the efficacy of intensive craniocervical screening before elective cardiovascular surgery. METHODS: A retrospective analysis of 1134 consecutive patients who underwent routine screening before cardiovascular surgery between November 2004 and December 2014 was conducted. The study was divided into 2 distinct cohorts of patients undergoing surgery: before (n = 500) and after (n = 634) the introduction of intensive screening in January 2009...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
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