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https://www.readbyqxmd.com/read/28549347/the-roles-of-ing5-in-gliomas-a-good-marker-for-tumorigenesis-and-a-potential-target-for-gene-therapy
#1
Shuang Zhao, Zhi-Juan Zhao, Hao-Yu He, Ji-Cheng Wu, Xiao-Qing Ding, Lei Yang, Ning Jia, Zhi-Jie Li, Hua-Chuan Zheng
To elucidate the anti-tumor effects and molecular mechanisms of ING5 on glioma cells, we overexpressed it in U87 cells, and examined the phenotypes and their relevant molecules. It was found that ING5 overexpression suppressed proliferation, energy metabolism, migration, invasion, and induced G2/M arrest, apoptosis, dedifferentiation, senescence, mesenchymal- epithelial transition and chemoresistance to cisplatin, MG132, paclitaxel and SAHA in U87 cells. There appeared a lower expression of N-cadherin, Twist, Slug, Zeb1, Zeb2, Snail, Ac-H3, Ac-H4, Cdc2, Cdk4 and XIAP, but a higher expression of Claudin 1, Histones 3 and 4, p21, p53, Bax, β-catenin, PI3K, Akt, and p-Akt in ING5 transfectants...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28549296/formation-mechanism-of-%C3%AE-lactalabumin-oleic-acid-complex-characterized-by-2d-correlation-analysis
#2
Yeonju Park, Yeseul Kim, Yujeong Park, Sila Jin, Hoon Hwang, Young Mee Jung
Partially unfolded α-lactalbumin (ALA) forms a complex with oleic acid (OA) that exhibits cytotoxic activity. In this study, for the first time, the pH-induced formation mechanism for ALA/OA complexes with two different molar ratios was investigated at the molecular level. For a deeper understanding of the formation mechanism of the two different ALA/OA complexes with decreasing pH, principal component analysis (PCA) and two-dimensional (2D) correlation spectroscopy were used to examine the pH-dependent IR spectra of ALA/OA complexes...
May 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28549295/structural-characterization-of-astaxanthin-aggregates-as-revealed-by-analysis-and-simulation-of-optical-spectra
#3
Liping Lu, Taoping Hu, Zhigang Xu
Carotenoids can self-assemble in hydrated polar solvents to form J- or H-type aggregates, inducing dramatic changes in photophysical properties. Here, we measured absorption and emission spectra of astaxanthin in ethanol-water solution using ultraviolet-visible and fluorescence spectrometers. Two types of aggregates were distinguished in mixed solution at different water contents by absorption spectra. After addition of water, all probed samples immediately formed H-aggregates with maximum blue shift of 31nm...
May 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28549212/synthesis-of-four-monoterpene-derived-organosulfates-and-their-quantification-in-atmospheric-aerosol-samples
#4
Yuchen Wang, Jingyun Ren, X H Hilda Huang, Rongbiao Tong, Jian Zhen Yu
Monoterpenes, a major class of biogenic volatile organic compounds, are known to produce oxidation products that further react with sulfate to form organosulfates. The accurate quantification of monoterpene-derived organosulfates (OSs) is necessary for quantifying this controllable aerosol source; however, it has been hampered by a lack of authentic standards. Here we report a unified synthesis strategy starting from the respective monoterpene through Upjohn dihydroxylation or Sharpless asymmetric dihydroxylation followed by mono-sulfation with sulfur trioxide-pyridine complex...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28549168/assessing-the-thermal-dissipation-sap-flux-density-method-for-monitoring-cold-season-water-transport-in-seasonally-snow-covered-forests
#5
Allison M Chan, David R Bowling
Productivity of conifers in seasonally snow-covered forests is high before and during snowmelt when environmental conditions are optimal for photosynthesis. Climate change is altering the timing of spring in many locations, and changes in the date of transition from winter dormancy can have large impacts on annual productivity. Sap flow methods provide a promising approach to monitor tree activity during the cold season and the winter-spring and fall-winter transitions. Although sap flow techniques have been widely used, cold season results are generally not reported...
May 26, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28549095/klf4-plays-an-essential-role-in-corneal-epithelial-homeostasis-by-promoting-epithelial-cell-fate-and-suppressing-epithelial-mesenchymal-transition
#6
Anil Tiwari, Chelsea L Loughner, Sudha Swamynathan, Shivalingappa K Swamynathan
Purpose: The purpose of this study was to test the hypothesis that KLF4 promotes corneal epithelial (CE) cell fate by suppressing the epithelial-mesenchymal transition (EMT), using spatiotemporally regulated CE-specific ablation of Klf4 in Klf4Δ/ΔCE (Klf4LoxP/LoxP/Krt12rtTA/rtTA/Tet-O-Cre) mice. Methods: CE-specific ablation of Klf4 was achieved by feeding Klf4Δ/ΔCE mice with doxycycline chow. The wild-type (WT; normal chow-fed littermates) and the Klf4Δ/ΔCE histology was compared by hematoxylin and eosin-stained sections; EMT marker expression was quantified by quantitative PCR, immunoblots, and immunofluorescent staining; and wound healing rate was measured by CE debridement using Algerbrush...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549082/pharmacokinetics-and-pharmacodynamics-of-propofol-changes-in-patients-with-frontal-brain-tumours
#7
M M Sahinovic, D J Eleveld, T Miyabe-Nishiwaki, M M R F Struys, A R Absalom
Background: Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations. The goal of this study was to determine if the presence of a frontal brain tumour influences propofol pharmacokinetics and pharmacodynamics and existing PK-PD model performance. Methods: Twenty patients with a frontal brain tumour and 20 control patients received a propofol infusion to achieve an induction-emergence-induction anaesthetic sequence...
May 26, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28548955/exploring-brusatol-as-a-new-anti-pancreatic-cancer-adjuvant-biological-evaluation-and-mechanistic-studies
#8
Zheng Lu, Zheng-Quan Lai, Albert W N Leung, Po Sing Leung, Zhao-Shen Li, Zhi-Xiu Lin
Pancreatic cancer is highly resistant to chemotherapeutic agents and is known to have a poor prognosis. The development of new therapeutic entities is badly needed for this deadly malignancy. In this study, we demonstrated for the first time that brusatol, a natural quassinoid isolated from a Chinese herbal medicine named Bruceae Fructus, possessed potent cytotoxic effect against different pancreatic adenocarcinoma cell lines. Its anti-pancreatic cancer effect was comparable to that of the first-line chemotherapeutic agents such as gemcitabine and 5-fluorouracil, with a more favorable safety profile...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548934/ikbke-regulates-cell-proliferation-and-epithelial-mesenchymal-transition-of-human-malignant-glioma-via-the-hippo-pathway
#9
Jie Lu, Yi Yang, Gaochao Guo, Yang Liu, Zhimeng Zhang, Shicai Dong, Yang Nan, Zhenyi Zhao, Yue Zhong, Qiang Huang
IKBKE is increased in several types of cancers and is associated with tumour malignancy. In this study, we confirmed that IKBKE promoted glioma proliferation, migration and invasion in vitro. Then, we further discovered that IKBKE increased Yes-associated protein 1 (YAP1) and TEA domain family member 2 (TEAD2), two important Hippo pathway downstream factors, to induce an epithelial-mesenchymal transition (EMT), thus contributing to tumour invasion and metastasis. We also testified that YAP1 and TEAD2 promoted epithelial-mesenchymal transition (EMT) in malignant glioma...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548917/family-experiences-of-the-transition-to-palliative-care-in-aged-residential-care-arc-a-qualitative-study
#10
Rosemary Frey, Susan Foster, Michal Boyd, Jackie Robinson, Merryn Gott
PURPOSE: To address a gap in the literature by exploring bereaved families' perceptions of the transition to palliative care for their relative in long-term care. METHODS: In-depth interviews were conducted with a convenience sample of twenty-six family members who were most involved in the care of residents who had died within the last 12 months. Interviews explored care, perceptions of staff palliative care knowledge, communication with staff, care planning and decision-making...
May 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28548903/microenvironment-of-a-tumor-organoid-system-enhances-hepatocellular-carcinoma-malignancy-related-hallmarks
#11
Yang Wang, Kazuki Takeishi, Zhao Li, Eduardo Cervantes-Alvarez, Alexandra Collin de l'Hortet, Jorge Guzman-Lepe, Xiao Cui, Jiye Zhu
Organ-like microenviroment and 3-dimensional (3D) cell culture conformations have been suggested as promising approaches to mimic in a micro-scale a whole organ cellular functions and interactions present in vivo. We have used this approach to examine biologic features of hepatocellular carcinoma (HCC) cells. In this study, we demonstrate that hepatocellular carcinoma (HCC) cells, fibroblasts, endothelial cells and extracellular matrix can generate organoid-like spheroids that enhanced numerous features of human HCC observed in vivo...
May 26, 2017: Organogenesis
https://www.readbyqxmd.com/read/28548868/inhaled-corticosteroid-prescribing-in-a-pediatric-emergency-department-sustained-success-and-prescription-filling-rates
#12
Sarah Nicole Adams, Mary Abel, Dustin Fowler, Jennifer Braden, Myla D Ebeling, Annie N Simpson, M Olivia Titus, Annie Lintzenich Andrews
OBJECTIVE: To determine if improvement in Inhaled Corticosteroid (ICS) prescribing in the pediatric emergency department (PED) can be sustained after transition from intense intervention to low-intervention phase, and to determine ICS fill rates. METHODS: A Quality Improvement (QI) project began in Aug 2012. Results through Feb 2014 were previously published. In Feb 2014 interventions were scaled back to determine the sustainability of QI success. Eligible patients included children aged 2-17 seen in the PED for asthma between Feb 2014 and Sept 2016...
May 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28548861/emergent-optical-phononic-modes-upon-nanoscale-mesogenic-phase-transitions
#13
Dima Bolmatov, Mikhail Zhernenkov, Lewis Sharpnack, Dena M Agra-Kooijman, Satyendra Kumar, Alexey Suvorov, Ronald Pindak, Yong Q Cai, Alessandro Cunsolo
The investigation of phononic collective excitations in soft matter systems at the molecular scale has always been challenging due to limitations of experimental techniques in resolving low-energy modes. Recent advances in Inelastic X-ray Scattering (IXS) enabled the study of such systems with unprecedented spectral contrast at meV excitation energies. In particular, it has become possible to shed light on the low-energy collective motions in materials whose morphology and phase behavior can easily be manipulated, such as mesogenic systems...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28548860/direct-imaging-of-kinetic-pathways-of-atomic-diffusion-in-monolayer-molybdenum-disulfide
#14
Jinhua Hong, Yuhao Pan, Zhixin Hu, Danhui Lv, Chuanhong Jin, Wei Ji, Jun Yuan, Ze Zhang
Direct observation of atomic migration both on and below surfaces is a long-standing but important challenge in materials science as diffusion is one of the most elementary processes essential to many vital material behaviors. Probing the kinetic pathways, including metastable or even transition states involved down to atomic scale, holds the key to the underlying physical mechanisms. Here, we applied aberration-corrected transmission electron microscopy (TEM) to demon-strate direct atomic-scale imaging and quasi-real-time tracking of diffusion of Mo adatoms and vacancies in monolayer MoS2, an important 2D transition metal dichalcogenide (TMD) system...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28548848/quantum-mechanical-study-of-the-reaction-mechanism-for-2%C3%AF-2%C3%AF-cycloaddition-of-fluorinated-methylene-groups
#15
Andrew R Motz, Andrew M Herring, Shubham Vyas, C Mark Maupin
Perfluorocyclobutyl polymers are thermally and chemically stable, may be produced without a catalyst via thermal 2π-2π cycloaddition, and can form block structures making them suitable for commercialization of specialty polymers. Thermal 2π-2π cycloaddition is a rare reaction that starts in the singlet state and proceeds through a triplet intermediate forming an energetically stable 4 membered ring in the singlet state. This reaction involves two changes in spin state and thus two spin-crossover transitions...
May 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28548846/ambient-size-distributions-and-lung-deposition-of-aerosol-dithiothreitol-measured-oxidative-potential-a-contrast-between-soluble-and-insoluble-particles
#16
Ting Fang, Linghan Zeng, Dong Gao, Vishal Verma, Aleksandr B Stefaniak, Rodney J Weber
Ambient particulate matter (PM) may upset redox homeostasis leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OP^DTT (dithiothreitol assay, measure of oxidative potential per air volume) are reported for a road-side and urban site. The average water-insoluble fractions were 23% and 51%, and 37% and 39% for fine and coarse mode at the road-side and urban site, respectively, measured during different periods. Water-soluble OP^DTT was unimodal peaked near 1-2...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548844/two-dynamical-regimes-of-the-substrate-radical-rearrangement-reaction-in-b12-dependent-ethanolamine-ammonia-lyase-resolve-contributions-of-native-protein-configurations-and-collective-configurational-fluctuations-to-catalysis
#17
Meghan Kohne, Chen Zhu, Kurt Warncke
The kinetics of the substrate radical rearrangement reaction step in B12-dependent ethanolamine ammonia-lyase (EAL) from Salmonella typhimurium are measured over a 92 K temperature range. The observed first-order rate constants display a piecewise-continuous Arrhenius dependence, with linear regions over 295→220 K (monoexponential) and 214→203 K (biexponential) that are delineated by a kinetic bifurcation and kinks at 219 and 217 K, respectively. The results are interpreted by using a free energy landscape model and derived microscopic kinetic mechanism...
May 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28548842/engineering-the-composition-and-structure-of-bimetallic-au-cu-alloy-nanoparticles-in-carbon-nanofibers-self-supported-electrode-materials-for-electrocatalytic-water-splitting
#18
Juan Wang, Han Zhu, Danni Yu, JiaWei Chen, JiaDong Chen, Ming Zhang, LiNa Wang, MingLiang Du
The bimetallic Au-Cu alloy nanoparticles have been constructed in electrospun carbon nanofibers (Au-Cu/CNFs), employing as high efficient hydrogen evolution reaction (HER) electrode. The morphology, structure and composition of bimetallic Au-Cu alloy can be controlled by adjusting the precursor nanofibers through a facile approach. With the increased Cu contents, the Au-Cu alloy have a transition from homogenous AuCu3 alloy phase to Au3Cu phase with Cu shell. The self-supported bimetallic Au-Cu/CNFs hybrid can be directly employed as electrodes materials for water splitting and it showed excellent electrochemical activity, including long-term stability, high exchange current density and low overpotential...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28548839/structural-distortions-and-charge-density-waves-in-iodine-chains-encapsulated-inside-carbon-nanotubes
#19
Hannu-Pekka Komsa, Ryosuke Senga, Kazutomo Suenaga, Arkady V Krasheninnikov
Atomic chains are perfect systems for getting fundamental insights into the electron dynamics and coupling between the electronic and ionic degrees of freedom in one dimensional metals. Depending on the band filling, they can exhibit Peierls instabilities (or charge density waves), where equally spaced chain of atoms with partially filled band is inherently unstable, exhibiting spontaneous distortion of the lattice that further leads to metal-insulator transition in the system. Here, using high-resolution scanning transmission electron microscopy, we directly image the atomic structures of a chain of iodine atoms confined inside carbon nanotubes...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28548673/laser-triggered-phase-transition-in-photothermal-liquid-crystals
#20
Mathieu Ciancone, Franck Camerel
Reversible high temperature phase transitions were easily induced under laser irradiation in pure thermotropic liquid crystals built around photothermal nickel-bis(dithiolene) cores. The strong photothermal activity of nickel-bis(dithiolene) liquid crystalline thin films allows reaching a temperature as high as 250 °C directly from room temperature in a few seconds with high spatial control.
May 26, 2017: Chemical Communications: Chem Comm
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