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https://www.readbyqxmd.com/read/28647948/gender-creative-or-transgender-youth-and-advanced-nursing-practice
#1
Nicole Kirouac, Mabel Tan
The World Professional Association for Transgender Health (WPATH) defines gender dysphoria as "Discomfort or distress that is caused by a discrepancy between a person's gender identity and that person's sex assigned at birth (and the associated gender role and/or primary and secondary sex characteristics)" (WPATH, 2016). Gender creative (GC) and transgender (TG) youth are at high risk for severe mental health disparities if they don't receive competent and timely gender transitioning care. Although awareness and early care of TG youth in specialty clinics is improving and increasing, there is still much effort that is required to eliminate barriers to care at many levels and thus improve outcomes...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28647945/the-emerging-adult-with-diabetes-transitioning-from-pediatric-to-adult-care
#2
Jodi Krall, Ingrid Libman, Linda Siminerio
Transfer from pediatric to adult health care is a significant life event for youth with chronic medical conditions. Unfortunately, youth may not be well prepared to navigate the shift in health care services, increasing their risk for loss to follow up and poor health outcomes. This review explores transition in care through the lens of type 1 diabetes, highlighting current practices and guidelines and offering recommendations for future consideration. Limited evidence suggests that transition programs that focus on strategies to prepare youth developmentally and equip the health care system appropriately have positive impact on the hand off of care, and health outcomes...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28647872/identification-and-characterization-of-intramolecular-%C3%AE-halo-interaction-in-d-0-complexes-a-theoretical-approach
#3
Tanay Debnath, Tamalika Ash, Subhendu Sarkar, Abhijit K Das
A mechanistic investigation to detect intramolecular M⋯X-C type interactions in d(0) neutral and cationic complexes was carried out through a benchmark study employing different density functional methods. As γ-halogen is involved in M⋯X-C type interactions, it is denoted as a γ-halo interaction and the respective conformers are designated as halo-conformers. By analyzing the geometrical parameters of halo-conformers, it was observed that, irrespective of the nature of the metal and the halogen, the Cγ-X bond distance increases compared to the usual C-X bond, which brings the M and X centers close enough to generate a weak interaction...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28647675/abstinence-from-prolonged-ethanol-exposure-affects-plasma-corticosterone-glucocorticoid-receptor-signaling-and-stress-related-behaviors
#4
Sucharita S Somkuwar, Leandro F Vendruscolo, McKenzie J Fannon, Brooke E Schmeichel, Tran Bao Nguyen, Jasmin Guevara, Harpreet Sidhu, Candice Contet, Eric P Zorrilla, Chitra D Mandyam
Alcohol dependence is linked to dysregulation of the hypothalamic-pituitary-adrenal axis. Here, we investigated effects of repeated ethanol intoxication-withdrawal cycles (using chronic intermittent ethanol vapor inhalation; CIE) and abstinence from CIE on peak and nadir plasma corticosterone (CORT) levels. Irritability- and anxiety-like behaviors as well as glucocorticoid receptors (GR) in the medial prefrontal cortex (mPFC) were assessed at various intervals (2h-28d) after cessation of CIE. Results show that peak CORT increased during CIE, transiently decreased during early abstinence (1-11d), and returned to pre-abstinence levels during protracted abstinence (17-27d)...
June 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28647577/transitions-from-skilled-nursing-facility-to-home-the-relationship-of-early-outpatient-care-to-hospital-readmission
#5
Jennifer L Carnahan, James E Slaven, Christopher M Callahan, Wanzhu Tu, Alexia M Torke
BACKGROUND: Many adults are discharged to skilled nursing facilities (SNFs) prior to returning home from the hospital. Patient characteristics and factors that can help to prevent postdischarge adverse outcomes are poorly understood. OBJECTIVE: To identify whether early post-SNF discharge care reduces likelihood of 30-day hospital readmissions. DESIGN: Secondary data analysis using the Electronic Medical Record, Medicare, Medicaid and the Minimum Data Set...
June 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28647550/longitudinal-prediction-of-quality-of-life-scores-and-locomotion-in-individuals-with-traumatic-spinal-cord-injury
#6
Shivayogi V Hiremath, Nathan S Hogaboom, Melissa R Roscher, Lynn A Worobey, Michelle L Oyster, Michael L Boninger
OBJECTIVES: The study examined differences in quality of life scores for groups based on transitions in locomotion status at 1, 5, and 10 years post-discharge in a sample of people with spinal cord injury (SCI). We also investigated whether demographic factors and transitions in locomotion status can predict quality of life measures at these time points. DESIGN: Retrospective case study of the National SCI Database. SETTING: Model SCI Systems Centers...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28647549/motivational-interviewing-improves-sustainable-return-to-work-in-injured-workers-after-rehabilitation-a-cluster-randomized-controlled-trial
#7
Douglas P Gross, Joanne Park, Fahreen Rayani, Colleen M Norris, Shaniff Esmail
OBJECTIVE: To examine whether motivational interviewing (MI) leads to more sustainable return-to-work outcomes for injured workers undergoing rehabilitation. MI is a client-centred counselling approach that facilitates behavioural change through identifying and resolving ambivalence. DESIGN: A cluster randomised controlled trial was conducted with analysis at level of claimant (registration ISRCTN45748422). SETTING: The study was conducted at a workers' compensation rehabilitation facility in Edmonton, Canada...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28647547/beyond-education-and-income-identifying-novel-socioeconomic-correlates-of-cigarette-use-in-u-s-young-adults
#8
Andrea C Villanti, Amanda L Johnson, Jessica M Rath
Young adulthood is defined by transitions in family life, living situations, educational settings, and employment. As a result, education and income may not be appropriate measures of socioeconomic status (SES) in young people. Using a national sample of young adults aged 18-34 (n=3364; collected February 2016), we explored novel socioeconomic correlates of ever cigarette use, past 30-day cigarette use, and daily cigarette use, weighted to account for non-response. Measures of SES assessed current education, household income, employment status, and subjective financial situation (SFS) and childhood SES (maternal and paternal education, SFS during childhood, parental divorce before age 18)...
June 21, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28647496/a-comprehensive-complex-systems-approach-to-the-study-and-analysis-of-mammalian-cell-cycle-control-system-in-the-presence-of-dna-damage-stress
#9
Ali Abroudi, Sandhya Samarasinghe, Don Kulasiri
Not many models of mammalian cell cycle system exist due to its complexity. Some models are too complex and hard to understand, while some others are too simple and not comprehensive enough. Moreover, some essential aspects, such as the response of G1-S and G2-M checkpoints to DNA damage as well as the growth factor signalling, have not been investigated from a systems point of view in current mammalian cell cycle models. To address these issues, we bring a holistic perspective to cell cycle by mathematically modelling it as a complex system consisting of important sub-systems that interact with each other...
June 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28647442/the-impact-of-the-transition-from-volume-to-value-on-heart-failure-care-implications-of-novel-payment-models-and-quality-improvement-initiatives
#10
REVIEW
Dushyanth Srinivasan, Nihar R Desai
In response to wide variation in quality and outcomes as well as escalating health care costs, the U.S. health care system is transitioning away from a volume based payment system to a quality- and value-based system. Medicare, the largest insurer and payer of healthcare, has accelerated the movement towards value-based care with the development and implementation of myriad alternative payment models and pay for performance programs as part of the Affordable Care Act. Given that heart failure affects a significant number of Medicare patients and these patients account for a disproportionate amount of healthcare utilization and spending, heart failure has become a focal point for these initiatives...
June 21, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28647432/peer-assisted-learning-intensity-modulated-radiotherapy-transition-in-developing-countries
#11
I Mohamad, A Salem, T Abu Hejleh, S Wadi-Ramahi, M Qandeel, S El Khatib, W Asha, S Mhied, O Al Saraireh, W Al-Gargaz, H Abdulelah, A Hosni, A Al Mousa
Intensity-modulated radiotherapy (IMRT) is not widely used in developing countries due to technical challenges and a lack of expertise and resources. We outline head and neck cancer IMRT implementation challenges and highlight how improvised solutions allowed successful IMRT transition in Jordan. This article showcases a 'peer-assisted learning' model, promoting IMRT transition in other developing countries. Unlike the 'top-down' approach, this model is uncommonly addressed in oncology journals. Developing countries could benefit from this article to enhance the adoption of modern radiotherapy technology...
June 21, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28647405/docosahexaenoic-acid-promotes-oligodendrocyte-differentiation-via-ppar-%C3%AE-signalling-and-prevents-tumor-necrosis-factor-%C3%AE-dependent-maturational-arrest
#12
A Bernardo, M L Giammarco, C De Nuccio, M A Ajmone-Cat, S Visentin, R De Simone, L Minghetti
Docosahexaenoic acid (DHA) is an essential omega-3 fatty acid known to be neuroprotective in several models of human diseases, including multiple sclerosis. The protective effects of DHA are largely attributed to its ability to interfere with the activity of transcription factors controlling immune and inflammatory responses, including the agonist-dependent transcription factor peroxisome proliferator-activated receptor-γ (PPAR-γ). In this study, we used primary oligodendrocyte progenitor (OP) cultures from neonatal rat brain to investigate whether DHA could influence OP maturation and directly promote myelination, as previously reported for selective PPAR-γ agonists...
June 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28647376/mitochondrial-permeability-transition-pore-back-to-the-drawing-board
#13
Christos Chinopoulos
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere...
June 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28647341/suppression-of-autophagic-flux-contributes-to-cardiomyocyte-death-by-activation-of-necroptotic-pathways
#14
Makoto Ogasawara, Toshiyuki Yano, Masaya Tanno, Koki Abe, Satoko Ishikawa, Takayuki Miki, Atsushi Kuno, Toshiyuki Tobisawa, Shingo Muratsubaki, Kouhei Ohno, Yuki Tatekoshi, Kei Nakata, Wataru Ohwada, Tetsuji Miura
BACKGROUND: The role of necroptosis in myocardial injury has not been fully characterized. Here we examined roles of mitochondrial permeability transition pore (mPTP) and autophagy in necroptosis of cardiomyocytes. METHODS AND RESULTS: In H9c2 cells, necroptosis was induced by treatment with TNF-α (TNF) and z-VAD-fmk (zVAD) for 24h, and necroptotic death was determined by LDH release (as % of total). TNF/zVAD increased LDH release from 16.6±4.3% to 60.6±2.7%, and the LDH release was suppressed by necrostatin-1 (29...
June 21, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28647204/return-to-competition-after-an-achilles-tendon-rupture-using-both-on-and-off-the-field-load-monitoring-as-guidance-a-case-report-of-a-top-level-soccer-player
#15
Maurizio Fanchini, Franco M Impellizzeri, Karin Grävare Silbernagel, Franco Combi, Franco Benazzo, Mario Bizzini
OBJECTIVES: To describe the Return to competition after Achilles Tendon rupture (ATR) in an elite soccer player. DESIGN: Case report. SETTING: Return to sport (RTS) of a professional soccer player who suffered an ATR during a match. The RTS phase started 15 weeks after surgery and specific on-field activities were gradually introduced. Criteria used to monitor the transition through the different phases were strength and endurance of the calf muscle and ability to sustain specific on-field training loads (TL) monitored with Global Positioning System and heart-rate system...
April 29, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28647197/characterizing-tissue-perfusion-after-lower-extremity-intervention-using-two-dimensional-color-coded-digital-subtraction-angiography
#16
Ann H Kim, Andrew J Shevitz, Katherine L Morrow, Daniel E Kendrick, Karem Harth, Henry Baele, Vikram S Kashyap
OBJECTIVE: Digital subtraction angiography (DSA) of the peripheral arterial vasculature provides lumenographic information but only a qualitative assessment of blood flow. The ability to quantify adequate tissue perfusion of the lower extremities would enable real-time perfusion assessment during DSA of patients with peripheral arterial disease (PAD). In this study, we used a novel real-time imaging software to delineate tissue perfusion parameters in the foot in PAD patients. METHODS: Between March 2015 and June 2016, patients (N = 31) underwent lower extremity angiography using a two-dimensional perfusion (2DP) imaging protocol (Philips Healthcare, Andover, Mass)...
June 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28647083/the-production-of-3d-tumor-spheroids-for-cancer-drug-discovery
#17
REVIEW
Shilpa Sant, Paul A Johnston
New cancer drug approval rates are ≤5% despite significant investments in cancer research, drug discovery and development. One strategy to improve the rate of success of new cancer drugs transitioning into the clinic would be to more closely align the cellular models used in the early lead discovery with pre-clinical animal models and patient tumors. For solid tumors, this would mandate the development and implementation of three dimensional (3D) in vitro tumor models that more accurately recapitulate human solid tumor architecture and biology...
March 2017: Drug Discovery Today. Technologies
https://www.readbyqxmd.com/read/28647060/lipid-droplets-can-spontaneously-bud-off-from-a-symmetric-bilayer
#18
François Deslandes, Abdou Rachid Thiam, Lionel Forêt
Lipid droplets (LDs) are cytosolic organelles that protrude from the endoplasmic reticulum membrane under energy-rich conditions. How an LD buds off from the endoplasmic reticulum bilayer is still elusive. By using a continuous media description, we computed the morphology of a lipid droplet embedded in between two identical monolayers of a bilayer. We found that beyond a critical volume, the droplet morphology abruptly transits from a symmetrical elongated lens to a spherical protrusion. This budding transition does not require any energy-consuming machinery, or curvature-inducing agent, or intrinsic asymmetry of the bilayer; it is solely driven by the large interfacial energy of the LD, as opposed to the bilayer surface tension...
June 21, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28647049/targeting-of-regulated-necrosis-in-kidney-disease
#19
Diego Martin-Sanchez, Jonay Poveda, Miguel Fontecha-Barriuso, Olga Ruiz-Andres, María Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belén Sanz
The term acute tubular necrosis was thought to represent a misnomer derived from morphological studies of human necropsies and necrosis was thought to represent an unregulated passive form of cell death which was not amenable to therapeutic manipulation. Recent advances have improved our understanding of cell death in acute kidney injury. First, apoptosis results in cell loss, but does not trigger an inflammatory response. However, clumsy attempts at interfering with apoptosis (e.g. certain caspase inhibitors) may trigger necrosis and, thus, inflammation-mediated kidney injury...
June 21, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28647040/synthesis-of-some-transition-metal-m-25mn-27co-28ni-29cu-30zn-47ag-48cd-sulfide-nanostructures-by-hydrothermal-method
#20
REVIEW
Hamid Emadi, Masoud Salavati-Niasari, Azam Sobhani
The design of nanostructures with favored shape, particle size and structure is one of the most important fields of nanoscience. To reach this target hydrothermal method is one of the most applicable methods which allow us to obtain favored structures by changing some parameters. This review focuses on synthesis of some transition metal sulfides by hydrothermal method because of technological importance of this group of material. The common sulfides of Mn, Co, Ni, Cu, Zn, Ag and Cd are introduced and a mechanism proposed for their synthesis...
June 16, 2017: Advances in Colloid and Interface Science
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