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https://www.readbyqxmd.com/read/29684855/post-transcription-mediated-snail-stabilization-is-involved-in-radiation-exposure-induced-invasion-and-migration-of-hepatocarcinoma-cells
#1
Liyang Dong, Xuebang Zhang, Wei Xiang, Junwei Ni, Weizhong Zhou, Haiyan Li
Increasing evidences suggested that radiotherapy can paradoxically promote tumor invasion and metastatic processes, while its detailed mechanism is not well illustrated. Our present study found that radiation can promote the migration and invasion of hepatocellular carcinoma (HCC) cells via induction of epithelial mesenchymal transition (EMT), which was evidenced by the results that radiation induced up regulation of vimentin while down regulation of E-Cadherin. As to the EMT-related transcription factors, radiation increased the expression of Snail, while not Slug, ZEB1 or TWIST...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684852/polysaccharide-from-rhizopus-nigricans-inhibits-the-invasion-and-metastasis-of-colorectal-cancer
#2
Zhidan Yu, Qingjie Sun, Jing Liu, Xiujuan Zhang, Ge Song, Guodong Wang, Pengying Zhang, Kaoshan Chen
Polysaccharide (EPS1-1) extracted from fermentation liquor of Rhizopus nigricans possesses antitumor and immune-enhancing activities. The study was the first to investigate the anti-metastasis effects of EPS1-1 in vitro and in vivo. Results suggested that EPS1-1 dose-dependently suppressed the migration, invasion and adhesion abilities of CT26 cells. Furthermore, EPS1-1 dramatically inhibited the enzyme activity and expression levels of matrix metalloproteinases (MMPs) in CT26 cells, as well as the tube formation of HUVECs...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684838/-doing-it-for-real-now-the-transition-from-healthcare-assistant-to-newly-qualified-nurse-a-qualitative-study
#3
Jan Draper
BACKGROUND: There has been increasing international research and policy interest concerning the transition from student to newly qualified nurse (NQN). However, the influence of previous employment as a healthcare assistant (HCA) on students' experiences of this transition is comparatively under-researched. AIMS AND OBJECTIVES: To explore the experiences of NQNs also employed as HCAs during their pre-registration education programme and how this prior and ongoing HCA experience influenced their transition experiences...
April 16, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29684798/clinging-to-closeness-the-parental-view-on-developing-a-close-bond-with-their-infants-in-a-nicu
#4
Heli Mäkelä, Anna Axelin, Nancy Feeley, Hannakaisa Niela-Vilén
OBJECTIVE: To identify and understand how parents develop a close bond to their infants in the neonatal intensive care unit (NICU). DESIGN: A qualitative descriptive study; closeness and separation stories recorded in a smartphone application by the parents were analyzed using thematic analysis. SETTING AND PARTICIPANTS: Twenty-three parents of nineteen infants who were taken care of in a level III NICU in Finland. FINDINGS: Bonding moments and a disrupted dyadic parent-infant relationship continuously alternated as in a rollercoaster ride during the hospital stay...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29684780/the-influence-of-landscape-s-dynamics-on-the-oriental-migratory-locust-habitat-change-based-on-the-time-series-satellite-data
#5
Yue Shi, Wenjiang Huang, Yingying Dong, Dailiang Peng, Qiong Zheng, Puyun Yang
Landscape structure and vegetation coverage are important habitat conditions for Oriental Migratory Locust infestation in East Asia. Characterizing the landscape's dynamics of locust habitat is meaningful for reducing the occupation of locusts and limiting potential risks. To better understand causes and consequences of landscape pattern and locust habitat, it is not enough to simply detect locust habitat of each year. Rather, landcover transitions causing the change of locust habitat area must also be explored...
April 20, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29684719/interhelical-interactions-between-d92-and-c218-in-the-cytoplasmic-domain-regulate-proton-uptake-upon-n-decay-in-the-proton-transport-of-acetabularia-rhodopsin-ii
#6
Jun Tamogami, Takashi Kikukawa, Keisuke Ohkawa, Noboru Ohsawa, Toshifumi Nara, Makoto Demura, Seiji Miyauchi, Tomomi Kimura-Someya, Mikako Shirouzu, Shigeyuki Yokoyama, Kazumi Shimono, Naoki Kamo
Acetabularia rhodopsin II (ARII or Ace2), an outward light-driven algal proton pump found in the giant unicellular marine alga Acetabularia acetabulum, has a unique property in the cytoplasmic (CP) side of its channel. The X-ray crystal structure of ARII in a dark state suggested the formation of an interhelical hydrogen bond between C218ARII and D92ARII , an internal proton donor to the Schiff base (Wada et al., 2011). In this report, we investigated the photocycles of two mutants at position C218ARII : C218AARII which disrupts the interaction with D92ARII , and C218SARII which potentially forms a stronger hydrogen bond...
April 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684644/a-gyral-coordinate-system-predictive-of-fibre-orientations
#7
Michiel Cottaar, Matteo Bastiani, Charles Chen, Krikor Dikranian, David Van Essen, Timothy E Behrens, Stamatios N Sotiropoulos, Saad Jbabdi
When axonal fibres approach or leave the cortex, their trajectories tend to closely follow the cortical convolutions. To quantify this tendency, we propose a three-dimensional coordinate system based on the gyral geometry. For every voxel in the brain, we define a "radial" axis orthogonal to nearby surfaces, a "sulcal" axis along the sulcal depth gradient that preferentially points from deep white matter to the gyral crown, and a "gyral" axis aligned with the long axis of the gyrus...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684643/neural-dynamics-of-breaking-continuous-flash-suppression
#8
Magdalena Del Río, Mark W Greenlee, Gregor Volberg
Sensory input to the human visual system often becomes accessible to cognition and overt report during processing. We investigated neural precursors of conscious vision using EEG recordings and the popular breaking continuous flash suppression (bCFS) paradigm. In this technique, a mask consisting of high-contrast dynamic patterns is presented to one eye, predominating over a target stimulus presented to the other eye. The time needed for the target stimulus to overcome the suppression is thought to reflect the transition from unconscious to conscious perception...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684624/component-effect-of-stem-cell-loaded-thermosensitive-polypeptide-hydrogels-on-cartilage-repair
#9
He Liu, Yilong Cheng, Jinjin Chen, Fei Chang, Jincheng Wang, Jianxun Ding, Xuesi Chen
Biophysical properties of the desired biomimetic scaffolds, such as porosity and elasticity, have been proven associated with the efficacy of cartilage regeneration. In this work, the copolymers of poly(L-alanine)-block-poly(ethylene glycol)-block-poly(L-alanine) (PA-PEG-PA) and poly(L-alanine-co-L-phenylalanine)-block-poly(ethylene glycol)-block-poly(L-alanine-co-L-phenylalanine) (PAF-PEG-PAF) with different ratios of alanine to phenylalanine were synthesized. The introduction of a hydrophobic amino acid, phenylalanine, into polyalanine-based thermosensitive hydrogel leaded to the enhanced gelation behaviors and upregulated mechanical properties...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684591/in-vitro-and-in-vivo-activity-of-opioid-cyclopeptide-with-mu-delta-agonist-profile-biased-toward-%C3%AE-arrestin
#10
Katarzyna Gach-Janczak, Justyna Piekielna-Ciesielska, Anna Adamska-Bartłomiejczyk, Karol Wtorek, Federica Ferrari, Girolamo Calo, Agata Szymaszkiewicz, Joanna Piasecka-Zelga, Anna Janecka
Replacement of the tyrosine residue in the mu-selective opioid ligand Tyr-c[D-Lys-Phe-Asp]NH2 with 2',6'-dimethyltyrosine (Dmt) produced a cyclopeptide Dmt-c[D-Lys-Phe-Asp]NH2 with mu/delta opioid receptor agonist profile. This new analog showed improved antinociception in the hot-plate test as compared to the parent but also significantly inhibited the gastrointestinal transit. Using the bioluminescence resonance energy transfer (BRET) assay it was shown that this analog was biased toward β-arrestin.
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684555/morphology-of-hindwing-veins-in-the-shield-bug-graphosoma-italicum-heteroptera-pentatomidae
#11
Paavo Bergmann, Sandra Richter, Nina Glöckner, Oliver Betz
Light, fluorescence, and electron microscopy were applied to cross sections and -breakage and whole-mount preparations of the anterior hindwing vein of the shield bug Graphosoma italicum. These analyses were complemented by investigations of the basal part of the forewing Corium and Clavus. The integration of structural, histological, and fluorescence data revealed a complex arrangement of both rigid and elastic structures in the wall of wing veins and provided insights into the constitution of transition zones between rigid and elastic regions...
April 20, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29684491/dynamic-regulation-of-mrna-and-mirna-associated-with-the-developmental-stages-of-skin-pigmentation-in-japanese-ornamental-carp
#12
Xue Tian, Xiaolei Pang, Liangyan Wang, Mengrong Li, Chuanju Dong, Xiao Ma, Lei Wang, Dongying Song, Jianxin Feng, Peng Xu, Xuejun Li
The Japanese ornamental carp (Cyprinus carpio var. Koi) is famous for multifarious colors and patterns, making it commonly culture and trade across the world. Although functional genes and inheritance of color traits have been commonly studied, seldom attentions were focused on the genetic regulation during the developmental process of pigmentation. To better understand the mechanism of skin color development, we observed the morphogenesis of pigment cells during the post-embryonic stages and analysed the temporal expression pattern of mRNAs/miRNAs profiles in four distinct developmental stages...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684384/knockdown-of-poldip2-suppresses-tumor-growth-and-invasion-capacity-and-is-linked-to-unfavorable-transformation-ability-and-metastatic-feature-in-non-small-cell-lung-cancer
#13
Ying-Chieh Chen, Chih-Chi Kuo, Chih-Feng Chian, Ching Tzao, Shan-Yueh Chang, Yu-Lueng Shih, Ya-Wen Lin, Mu-Hsien Yu, Her-Young Su
The main problem in the treatment of non-small cell lung cancer (NSCLC) is metastasis. Epithelial-mesenchymal transition (EMT) is known as the critical signaling in tumor progression, metastasis, and also the drug resistance. In this study, we reported a novel gene Polymerase delta-interacting protein 2 (POLDIP2) was downregulated in NSCLC tissues and first demonstrated that overexpression of POLDIP2 increased the anchorage-independent growth (AIG) and invasiveness of H1299 cells. In addition, we examined that knockdown of POLDIP2 in H1299 and A549 cells reduced tumorigenicity and metastatic capacity in vitro and also in vivo...
April 20, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29684311/tfam-is-required-for-maturation-of-the-fetal-and-adult-intestinal-epithelium
#14
Manasa Srivillibhuthur, Bailey N Warder, Natalie H Toke, Pooja P Shah, Qiang Feng, Nan Gao, Edward M Bonder, Michael P Verzi
During development, the embryo transitions from a metabolism favoring glycolysis to a metabolism favoring mitochondrial respiration. How metabolic shifts regulate developmental processes, or how developmental processes regulate metabolic shifts, remains unclear. To test the requirement of mitochondrial function in developing endoderm-derived tissues, we genetically inactivated the mitochondrial transcription factor, Tfam, using the Shh-Cre driver. Tfam mutants did not survive postnatally, exhibiting defects in lung development...
April 20, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29684276/layer-dependent-ultrafast-carrier-and-coherent-phonon-dynamics-in-black-phosphorus
#15
Xianchong Miao, Guowei Zhang, Fanjie Wang, Hugen Yan, Minbiao Ji
Black phosphorus is a layered semiconducting material, demonstrating strong layer-dependent optical and electronic properties. Probing the photophysical properties on ultrafast timescales is of central importance in understanding many-body interactions and non-equilibrium quasiparticle dynamics. Here, we applied temporally, spectrally and spatially resolved pump-probe microscopy to study the transient optical responses of mechanically exfoliated few-layer black phosphorous, with layer number ranging from 2 to 9...
April 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29684269/an-s-%C3%A2-iron-complex-featuring-n2-thiolate-and-hydride-ligands-reductive-elimination-of-h2-and-relevant-thermochemical-fe-h-parameters
#16
Nina X Gu, Paul H Oyala, Jonas C Peters
Believed to accumulate on the Fe sites of the FeMo-cofactor (FeMoco) of MoFe-nitrogenase under turnover, strongly donating hydrides have been proposed to facilitate N2 binding to Fe and may also participate in the hydrogen evolution process concomitant to nitrogen fixation. Here, we report the synthesis and characterization of a thiolate-coordinated FeIII(H)(N2) complex, which releases H2 upon warming to yield an FeII-N2-FeII complex. Bimolecular reductive elimination of H2 from metal hydrides is pertinent to the hydrogen evolution processes of both enzymes and electrocatalysts, but well-defined examples are uncommon and usually observed from diamagnetic second- and third-row transition metals...
April 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29684199/patterns-of-ses-health-disparities-among-older-adults-in-three-upper-middle-and-two-high-income-countries
#17
Mary McEniry, Rafael Samper-Ternent, Carmen Elisa Flórez, Renata Pardo, Carlos Cano-Gutierrez
Objectives: To examine the socioeconomic status (SES) health gradient for obesity, diabetes, and hypertension within a diverse group of health outcomes and behaviors among older adults (60+) in upper middle-income countries benchmarked with high-income countries. Method : We used data from three upper middle-income settings (Colombia-SABE-Bogotá, Mexico-SAGE, and South Africa-SAGE) and two high-income countries (England-ELSA and US-HRS) to estimate logistic regression models using age, gender, and education to predict health and health behaviors...
April 19, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29684089/alternative-ribosomal-proteins-are-required-for-growth-and-morphogenesis-of-mycobacterium-smegmatis-under-zinc-limiting-conditions
#18
Allexa Dow, Sladjana Prisic
Zinc is an essential micronutrient required for proper structure and function of many proteins. Bacteria regularly encounter zinc depletion and have evolved diverse mechanisms to continue growth when zinc is limited, including the expression of zinc-independent paralogs of zinc-binding proteins. Mycobacteria have a conserved operon encoding four zinc-independent alternative ribosomal proteins (AltRPs) that are expressed when zinc is depleted. It is unknown if mycobacterial AltRPs replace their primary paralogs in the ribosome and maintain protein synthesis under zinc-limited conditions, and if such replacements contribute to their physiology...
2018: PloS One
https://www.readbyqxmd.com/read/29683985/accommodative-behavior-of-young-eyes-wearing-multifocal-contact-lenses
#19
Basal H Altoaimi, Meznah S Almutairi, Pete S Kollbaum, Arthur Bradley
SIGNIFICANCE: The effectiveness of multifocal contact lenses (MFCLs) at slowing myopia progression may hinge on the accommodative behavior of young eyes fit with these presbyopic style lenses. Can they remove hyperopic defocus? Convergence accommodation as well as pupil size and the zonal geometry are likely to contribute to the final accommodative responses. PURPOSE: The aim of this study was to examine the accommodation behavior of young adult eyes wearing MFCLs and the effectiveness of these MFCLs at removing foveal hyperopic defocus when viewing near targets binocularly...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683892/implication-of-highly-cytotoxic-natural-killer-cells-for-esophageal-squamous-cell-carcinoma-treatment
#20
Kee Siang Lim, Kosaku Mimura, Ley-Fang Kua, Kensuke Shiraishi, Koji Kono
Esophageal squamous cell carcinoma (ESCC) is an aggressive upper gastrointestinal cancer and effective treatments are limited. Previous studies reported that natural killer (NK) cells expanded by coculturing with K562-mb15-41BBL feeder cells, a genetically modified K562 leukemia cell line that expresses membrane-bound interleukin (IL)-15 and 41BBL ligand, were highly proliferative and highly cytotoxic. Here, we investigated the potential of expanded NK cells for ESCC treatment. We analyzed both genetic and surface expression levels of NKG2D ligands (NKG2DLs) in ESCC using publicly available microarray data sets and ESCC cell lines...
April 20, 2018: Journal of Immunotherapy
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