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Smad AND Myricetin

Mingdao Mu, Peng An, Qian Wu, Xiaoyun Shen, Dandan Shao, Hao Wang, Yingqi Zhang, Shenshen Zhang, Hui Yao, Junxia Min, Fudi Wang
Hepcidin, a master regulator of iron homeostasis, is a promising target in treatment of iron disorders such as hemochromatosis, anemia of inflammation and iron-deficiency anemia. We previously reported that black soybean seed coat extract could inhibit hepcidin expression. Based on this finding, we performed a screen in cultured cells in order to identify the compounds in black soybeans that inhibit hepcidin expression. We found that the dietary flavonoid myricetin significantly inhibited the expression of hepcidin both in vitro and in vivo...
April 2016: Journal of Nutritional Biochemistry
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