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https://www.readbyqxmd.com/read/28528306/the-group-ii-intron-maturase-a-reverse-transcriptase-and-splicing-factor-go-hand-in-hand
#1
REVIEW
Chen Zhao, Anna Marie Pyle
The splicing of group II introns in vivo requires the assistance of a multifunctional intron encoded protein (IEP, or maturase). Each IEP is also a reverse-transcriptase enzyme that enables group II introns to behave as mobile genetic elements. During splicing or retro-transposition, each group II intron forms a tight, specific complex with its own encoded IEP, resulting in a highly reactive holoenzyme. This review focuses on the structural basis for IEP function, as revealed by recent crystal structures of an IEP reverse transcriptase domain and cryo-EM structures of an IEP-intron complex...
May 18, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28509920/insights-into-chemoselectivity-principles-in-metal-oxide-affinity-chromatography-using-tailored-nanocast-metal-oxide-microspheres-and-mass-spectrometry-based-phosphoproteomics
#2
Alexander Leitner, Motolani Sakeye, Christian Eugen Zimmerli, Jan-Henrik Smått
The ability to comprehensively characterize biological samples, including tissues and body fluids, opens up new possibilities to diagnose and treat diseases and to better understand fundamental biological processes. For this purpose, suitable experimental workflows need to be designed. In this context, materials with particular chemoselective properties are used for the enrichment of certain classes of (bio)molecules. Metal oxides such as titanium dioxide have become the materials of choice for the large-scale study of protein phosphorylation in phosphoproteomics...
May 16, 2017: Analyst
https://www.readbyqxmd.com/read/28507471/seroepidemiological-study-of-toxoplasma-gondii-infection-in-a-population-of-iranian-epileptic-patients
#3
Jalal Babaie, Mohammad Sayyah, Kourosh Gharagozli, Ehsan Mostafavi, Majid Golkar
Epilepsy is one of the most common neurologic disorders. Underlying cause of epilepsy is unknown in 60 % of the patients. Toxoplasma gondii is an intracellular parasite which is capable of forming tissue cysts in brain of chronically infected hosts including humans. Some epidemiological studies suggested an association between toxoplasmosis and acquisition of epilepsy. In this study we determined seroprevalence of latent Toxoplasma infection in a population of Iranian epileptic patients. Participants were classified in three groups as Iranian epileptic patients (IEP, n = 414), non-epileptic patients who had other neurologic disorders (NEP, n = 150), and healthy people without any neurologic disorders (HP, n = 63)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28506654/effect-of-number-of-firings-on-the-color-and-translucency-of-ceramic-core-materials-with-veneer-ceramic-of-different-thicknesses
#4
Funda Bayindir, Ozlem Ozbayram
STATEMENT OF PROBLEM: Whether masking or translucency should be the goal for achieving an esthetic restoration with ceramic materials is unknown. PURPOSE: The purpose of this in vitro study was to examine the effect of the number of firings on the color and translucency of ceramic core material with different thicknesses of veneer ceramic. MATERIAL AND METHODS: Three different ceramic systems were used: IPS Empress (IE), IPS e.max Press (IEP), and Turkom Cera (TC)...
May 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28454250/intensity-modulated-radiation-therapy-to-treat-primary-female-mediastinal-seminoma-and-massive-pericardial-effusion-a-case-report
#5
Jun Cao, Yan Zhou, Fangwen Zou, Jin-An Ma, Chunhong Hu
Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient received 6 cycles of cisplatin-based chemotherapy [4 cycles BEP chemotherapy (120 mg cisplatin, 0.45 g etoposide and 60 mg bleomycin, once every 3 weeks); 2 cycles IEP chemotherapy (120 mg cisplatin, 100 mg epirubicin and 6 g ifosfamide, once every 3 weeks)] and the patient showed an increase in the size of the mediastinal mass and hydropericardium, indicating a resistance to chemotherapy...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28320406/the-acceptability-and-feasibility-of-a-brief-psychosocial-intervention-to-reduce-blood-borne-virus-risk-behaviours-among-people-who-inject-drugs-a-randomised-control-feasibility-trial-of-a-psychosocial-intervention-the-protect-study-versus-treatment-as-usual
#6
Gail Gilchrist, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, John Strang, Avril Taylor, Judith Watson
BACKGROUND: While opiate substitution therapy and injecting equipment provision (IEP) have reduced blood-borne viruses (BBV) among people who inject drugs (PWID), some PWID continue to share injecting equipment and acquire BBV. Psychosocial interventions that address risk behaviours could reduce BBV transmission among PWID. METHODS: A pragmatic, two-armed randomised controlled, open feasibility study of PWID attending drug treatment or IEP in four UK regions. Ninety-nine PWID were randomly allocated to receive a three-session manualised psychosocial group intervention and BBV transmission information booklet plus treatment as usual (TAU) (n = 52) or information booklet plus TAU (n = 47)...
March 21, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28284055/synthesis-of-a-rare-earth-doped-hafnia-hydrosol-towards-injectable-luminescent-nanocolloids
#7
Aleksandra D Furasova, Anna F Fakhardo, Valentin A Milichko, Elena Tervoort, Markus Niederberger, Vladimir V Vinogradov
A major obstacle in the introduction of luminescent nanoparticles (NPs) for medical applications is that quantum dots, the most widely studied luminescent materials, despite being biologically safe after coating with a bioshell, still contain a toxic core mostly consisting of semi-conductor NPs, which are not approved by regulatory agencies. Here we point to a potential solution of this problem by using rare-earth (RE) doped hafnia NPs. Hafnia is approved for medical injections as an effective means for the treatment of radiosensitive and radioresistant tumors and can significantly decrease potential toxicity of RE ions...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28266537/mineral-surface-chemistry-and-nanoparticle-aggregation-control-membrane-self-assembly
#8
Nita Sahai, Hussein Kaddour, Punam Dalai, Ziqiu Wang, Garrett Bass, Min Gao
The self-assembly of lipid bilayer membranes to enclose functional biomolecules, thus defining a "protocell," was a seminal moment in the emergence of life on Earth and likely occurred at the micro-environment of the mineral-water interface. Mineral-lipid interactions are also relevant in biomedical, industrial and technological processes. Yet, no structure-activity relationships (SARs) have been identified to predict lipid self-assembly at mineral surfaces. Here we examined the influence of minerals on the self-assembly and survival of vesicles composed of single chain amphiphiles as model protocell membranes...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262018/large-rectification-effect-of-single-graphene-nanopore-supported-by-pet-membrane
#9
Huijun Yao, Jian Zeng, Pengfei Zhai, Zongzhen Li, Yaxiong Cheng, Jiande Liu, Dan Mo, Jinglai Duan, Lanxi Wang, Youmei Sun, Jie Liu
Graphene is an ideal candidate for the development of solid state nanopores due to its thickness at the atomic scale and its high chemical and mechanical stabilities. A facile method was adopted to prepare single graphene nanopore supported by PET membrane (G/PET nanopore) within the three steps assisted by the swift heavy ion irradiation and asymmetric etching technology. The inversion of the ion rectification effect was confirmed in G/PET nanopore while comparing with bare PET nanopore in KCl electrolyte solution...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28238264/influence-of-aqueous-inorganic-anions-on-the-reactivity-of-nanoparticles-in-tio2-photocatalysis
#10
Jeffrey Farner Budarz, Andrea Turolla, Aleksander F Piasecki, Jean-Yves Bottero, Manuela Antonelli, Mark R Wiesner
The influence of inorganic anions on the photoreactivity and aggregation of titanium dioxide nanoparticles (NPs) was assessed by dosing carbonate, chloride, nitrate, phosphate, and sulfate as potassium salts at multiple concentrations. NP stability was monitored in terms of aggregate morphology and electrophoretic mobility (EPM). Aggregate size and fractal dimension were measured over time by laser diffraction, and the isoelectric point (IEP) as a function of anion and concentration was obtained by measuring EPM versus pH...
March 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28165250/programmable-phase-transitions-in-a-photonic-microgel-system-linking-soft-interactions-to-a-temporal-ph-gradient
#11
Dennis Go, Dirk Rommel, Lisa Chen, Feng Shi, Joris Sprakel, Alexander J C Kuehne
Soft amphoteric microgel systems exhibit a rich phase behavior. Crystalline phases of these material systems are of interest because they exhibit photonic stop-gaps, giving rise to iridescent color. Such microgel systems are promising for applications in soft, switchable, and programmable photonic filters and devices. We here report a composite microgel system consisting of a hard and fluorescently labeled core and a soft, amphoteric microgel shell. At pH above the isoelectric point (IEP), these colloids easily crystallize into three-dimensional colloidal assemblies...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28079383/structure-and-interaction-in-the-ph-dependent-phase-behavior-of-nanoparticle-protein-systems
#12
Indresh Yadav, Sugam Kumar, Vinod K Aswal, Joachim Kohlbrecher
The pH-dependent structure and interaction of anionic silica nanoparticles (diameter 18 nm) with two globular model proteins, lysozyme and bovine serum albumin (BSA), have been studied. Cationic lysozyme adsorbs strongly on the nanoparticles, and the adsorption follows exponential growth as a function of lysozyme concentration, where the saturation value increases as pH approaches the isoelectric point (IEP) of lysozyme. By contrast, irrespective of pH, anionic BSA does not show any adsorption. Despite having a different nature of interactions, both proteins render a similar phase behavior where nanoparticle-protein systems transform from being one-phase (clear) to two-phase (turbid) above a critical protein concentration (CPC)...
January 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28075207/perceived-needs-for-different-components-in-a-rehabilitation-program-among-cancer-survivors-with-chronic-fatigue-compared-to-survivors-without-chronic-fatigue
#13
COMPARATIVE STUDY
Gunhild M Gjerset, Jon H Loge, Cecilie E Kiserud, Sophie D Fosså, Sævar B Gudbergsson, Line M Oldervoll, Torbjørn Wisløff, Lene Thorsen
BACKGROUND: Knowledge about the user' needs is important to develop targeted rehabilitation for cancer patients with chronic fatigue (CF). The aims of the study were to examine prevalence of CF in cancer survivors attending an one-week inpatient educational program (IEP) and to identify characteristics of those with CF. Further to examine the perceived needs for different components in a rehabilitation program, need of complex rehabilitation (at least two components) and aspects of health-related quality of life (HRQoL) among survivors with CF versus those without CF...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28069233/a-facile-sonochemical-synthesis-of-shell-stabilized-reactive-microbubbles-using-surface-thiolated-bovine-serum-albumin-with-the-traut-s-reagent
#14
Xiaochen Ma, Adrien Bussonniere, Qingxia Liu
The short lifetime of proteinaceous microbubbles produced using conventional sonication method has hindered their applications in drug delivery and metal removal from wastewater. In this study, we aimed to synthesize stable proteinaceous microbubbles and to demonstrate their reactivity. Our model protein, bovine serum albumin (BSA) was treated with 2-iminothiolane hydrochloride (Traut's reagent) to convert primary amines to thiols before the synthesis of microbubbles. Microbubbles produced with the Traut's reagent-treated BSA (BSA-SH MBs) were initially concentrated at median sizes of 0...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28063520/zeta-potential-of-artificial-and-natural-calcite-in-aqueous-solution
#15
REVIEW
Dawoud Al Mahrouqi, Jan Vinogradov, Matthew D Jackson
Despite the broad range of interest and applications, controls on calcite surface charge in aqueous solution, especially at conditions relevant to natural systems, remain poorly understood. The primary data source to understand calcite surface charge comprises measurements of zeta potential. Here we collate and review previous measurements of zeta potential on natural and artificial calcite and carbonate as a resource for future studies, compare and contrast the results of these studies to determine key controls on zeta potential and where uncertainties remain, and report new measurements of zeta potential relevant to natural subsurface systems...
February 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28041806/neurodevelopmental-exam-recommendations-for-children-with-hiv-infection
#16
Kathryn Brady, Madison Dipman, Erin Nelson, Megan Allen, Laura Clarke-Steffen, Amy Edmonds, Kiran Aurora, Janice Piatt
Multiple and complex health, social, and environmental factors threaten the school success of children living with HIV. Little is known about interventions to overcome these threats to school success. We aimed to identify the number and types of recommendations from hospital-generated neurodevelopmental exams and school-generated evaluations, Individual Education Plans (IEP), and 504 Plans for adaptations in the classroom for students with HIV infection. We also compared recommendations suggested by both neurodevelopmental exams and IEPs or 504 Plans...
May 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28025341/can-we-replace-curation-with-information-extraction-software
#17
REVIEW
Peter D Karp
Can we use programs for automated or semi-automated information extraction from scientific texts as practical alternatives to professional curation? I show that error rates of current information extraction programs are too high to replace professional curation today. Furthermore, current IEP programs extract single narrow slivers of information, such as individual protein interactions; they cannot extract the large breadth of information extracted by professional curators for databases such as EcoCyc. They also cannot arbitrate among conflicting statements in the literature as curators can...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27990469/attitude-towards-and-readiness-for-interprofessional-education-in-medical-and-nursing-students-of-bern
#18
Ulrich Woermann, Lena Weltsch, Alexandra Kunz, Daniel Stricker, Sissel Guttormsen
Objectives: Interprofessional collaboration is becoming increasingly important in health care for various reasons. Interprofessional Education (IPE) can provide a basis for this. The aim of our study was to find out how medical (MS) and nursing students (NS) think about their own and other professions, what they know about each other, how strong their willingness to embrace IPE is, and what forms of IPE they deem useful. Methodology: Seven IPE experts rated the two measuring instruments, Readiness for Interprofessional Learning Scale RIPLS, and Interdisciplinary Education Perception Scale IEPS in terms of relevance of the items, and the quality of translation into German...
2016: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/27890403/isoelectric-points-and-points-of-zero-charge-of-metal-hydr-oxides-50years-after-parks-review
#19
REVIEW
Marek Kosmulski
The pH-dependent surface charging of metal (hydr)oxides is reviewed on the occasion of the 50th anniversary of the publication by G.A. Parks: "Isoelectric points of solid oxides, solid hydroxides, and aqueous hydroxo complex systems" in Chemical Reviews. The point of zero charge (PZC) and isoelectric point (IEP) became standard parameters to characterize metal oxides in aqueous dispersions, and they define adsorption (surface excess) of ions, stability against coagulation, rheological properties of dispersions, etc...
December 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27814796/access-to-opportunities-for-bilingualism-for-individuals-with-developmental-disabilities-key-informant-interviews
#20
Julia Scherba de Valenzuela, Elizabeth Kay-Raining Bird, Karisa Parkington, Pat Mirenda, Kate Cain, Andrea A N MacLeod, Eliane Segers
The purpose of this article is to describe the results of a thematic analysis of 79 semi-structured interviews collected at six research sites in four countries in relation to the inclusion and exclusion of students with developmental disabilities (DD) in and from special education and bilingual opportunities. The participants were individuals with expertise either in special needs and/or language education to support bilingualism (e.g., second language (L2) instruction), who served as key informants about service delivery and/or policy in these areas...
September 2016: Journal of Communication Disorders
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