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https://www.readbyqxmd.com/read/28094301/the-occurrence-rate-of-acute-onset-postoperative-endophthalmitis-after-cataract-surgery-in-chinese-small-and-medium-scale-departments-of-ophthalmology
#1
Yanan Zhu, Xinyi Chen, Peiqing Chen, Jianjun Wu, Huixia Hua, Ke Yao
Endophthalmitis can be a devastating complication after cataract surgery. Therefore, this study sought to better understand the occurrence rate of acute-onset postoperative endophthalmitis after cataract surgery in Chinese small and medium-scale departments of ophthalmology, as well as identify its risk factors and assess the treatment options. This investigation revealed 52 postoperative endophthalmitis cases in 46,185 operations at 30 hospitals from 2011 to 2013, at an occurrence rate of 0.11%. A small cataract surgery volume of less than 500 cases per year (OR 2...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093431/which-is-best-for-osteoporotic-vertebral-compression-fractures-balloon-kyphoplasty-percutaneous-vertebroplasty-or-non-surgical-treatment-a-study-protocol-for-a-bayesian-network-meta-analysis
#2
Shun-Li Kan, Zhi-Fang Yuan, Ling-Xiao Chen, Jing-Cheng Sun, Guang-Zhi Ning, Shi-Qing Feng
INTRODUCTION: Osteoporotic vertebral compression fractures (OVCFs) commonly cause both acute and chronic back pain, substantial spinal deformity, functional disability and decreased quality of life and increase the risk of future vertebral fractures and mortality. Percutaneous vertebroplasty (PVP), balloon kyphoplasty (BK) and non-surgical treatment (NST) are mostly used for the treatment of OVCFs. However, which treatment is preferred is unknown. The purpose of this study is to comprehensively review the literature and ascertain the relative efficacy and safety of BK, PVP and NST for patients with OVCFs using a Bayesian network meta-analysis...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28089465/differential-bioaccumulation-patterns-of-nanosized-and-dissolved-silver-in-a-land-snail-achatina-fulica
#3
Yuanzhen Chen, Youbin Si, Dongmei Zhou, Fei Dang
With the increasing application in antimicrobial products, silver nanoparticles (AgNP) are inevitably released into the terrestrial environment, and pose potential risks to invertebrates such as land snails Achatina fulica, which take up AgNP from food and water. Here we differentiate Ag uptake biodynamic between Ag forms (i.e., PVP-AgNP vs. AgNO3) and between exposure pathways. Snails assimilated Ag efficiently from lettuce leaves pre-exposed to AgNP, with assimilation efficiencies (AEs) averaging 62-85% and food ingestion rates of 0...
January 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28087352/engineering-hot-melt-extruded-solid-dispersion-for-controlled-release-of-hydrophilic-drugs
#4
Shuli Zhang, Xuan Meng, Zheng Wang, Aiping Fan, Guocheng Wang, Yanjun Zhao, Yu Tang
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via rational screening of the pore-forming agents. Venlafaxine hydrochloride and Compritol® 888 ATO was selected as the model drug and carrier excipient, respectively. Hydrophilic polyethylene glycol (PEG 6000) and polyvinylpyrolidone (PVP K30) were chosen as the transient pore-forming agents...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28080061/evaluation-of-a-new-biosensor-based-on-in-situ-synthesized-ppy-ag-pvp-nanohybrid-for-selective-detection-of-dopamine
#5
Balakumar Vellaichamy, Prakash Periakaruppan, Tharmaraj Paulmony
In the present work, in-situ synthesis of polypyrrole-silver-polyvinylpyrrolidone (PPy-Ag-PVP) nonohybrid using AgNO3 as an oxidant and polyvinyl pyrrolidone (PVP) as a stabilizer and surfactant is demonstrated. The obtained ternary PPy-Ag-PVP nanohybrid was characterized by UV-vis, FT-IR, XRD, Raman, TGA, SEM and HR-TEM analysis. Further the synthesized PPy-Ag-PVP has been investigated for its selective and sensitive sensing of dopamine (DA). The PPy-Ag-PVP modified glassy carbon electrode shows a reversible electrochemical behavior with superior response for DA...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28079827/differentiating-malignant-from-benign-gastric-mucosal-lesions-with-quantitative-analysis-in-dual-energy-spectral-computed-tomography-initial-experience
#6
Xiaoyan Meng, Cheng Ni, Yaqi Shen, Xuemei Hu, Xiao Chen, Zhen Li, Daoyu Hu
To investigate the value of quantitative analysis in dual energy spectral computed tomography (DESCT) for differentiating malignant gastric mucosal lesions from benign gastric mucosal lesions (including gastric inflammation [GI] and normal gastric mucosa [NGM]). This study was approved by the ethics committee, and all patients provided written informed consent. A total of 161 consecutive patients (63 with gastric cancer [GC], 48 with GI, and 50 with NGM) who underwent dual-phase contrast enhanced DESCT scans in the arterial phase (AP) and portal venous phase (PVP) were included in this study...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079799/risk-factors-for-recollapse-of-the-augmented-vertebrae-after-percutaneous-vertebroplasty-for-osteoporotic-vertebral-fractures-with-intravertebral-vacuum-cleft
#7
Weibo Yu, De Liang, Zhensong Yao, Ting Qiu, Linqiang Ye, Xuecheng Huang, Xiaobing Jiang
To determine risk factors related to recollapse of the augmented vertebrae after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) with intravertebral vacuum cleft (IVC).Fifty-two patients treated with PVP for single OVCFs with the IVC were retrospectively reviewed. The follow-up period was at least 2 years. Vertebral height loss ≥15% or kyphotic angle ≥10° at the final follow-up in relation to the immediately postoperative values were adopted as a definition of recollapse of the augmented vertebrae...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079257/a-safe-cheap-and-easy-to-use-isotropic-diffusion-mri-phantom-for-clinical-and-multicenter-studies
#8
Pim Pullens, Piet Bladt, Jan Sijbers, Andrew I R Maas, Paul M Parizel
PURPOSE: Since Diffusion Weighted Imaging (DWI) data acquisition and processing are not standardized, substantial differences in DWI derived measures such as Apparent Diffusion Coefficient (ADC) may arise which are related to the acquisition or MRI processing method, but not to the sample under study. Quality assurance using a standardized test object, or phantom, is a key factor in standardizing DWI across scanners. METHODS: Current diffusion phantoms are either complex to use, not available in larger quantities, contain substances unwanted in a clinical environment, or are expensive...
January 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28077032/iodine-responsive-poly-hema-pvp-hydrogel-for-self-regulating-burst-free-extended-release
#9
Jinku Xu, Peili Zhao, Yongchun Zhang
Swollen hydrogels with extended iodine release kinetics is highly desirable for burn and scald treatment. In this paper semi-interpenetrating poly(HEMA-PVP) hydrogels were prepared by radical polymerization followed by thermo-treatment to crosslink its PVP component. Incorporation of PVP component endows the hydrogels responsive to loaded iodine undergoing a reversible shrunken/swollen volume transition. This resulted in a self-regulating iodine release model, in which shrunken hydrogel at high iodine loading decreased drug diffusion thereby reducing burst release,, and then gradually swollen hydrogel as drug release ensures rapid release of dissociated drug from strong affinity sites on hydrogel backbone, achieving a burst-free extended release...
January 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28072794/does-percutaneous-vertebroplasty-or-balloon-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-increase-the-incidence-of-new-vertebral-fractures-a-meta-analysis
#10
Hui Zhang, Caiyuan Xu, Tongxing Zhang, Zhongyu Gao, Tao Zhang
BACKGROUND: Because of an aging population,osteoporotic vertebral fractures are becoming more frequent.Conservative therapy was considered the gold standard for treating osteoporotic vertebral compression fractures (OVCFs) in the past. Percutaneous vertebroplasty (PVP) or balloon kyphoplasty (BKP) as minimally invasive techniques are new treatments that are widely used for painful OVCFs. However, an increase in new vertebral compression fractures at non-treated levels following augmentation is of concern...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28070038/-total-liver-ct-perfusion-imaging-for-evaluation-on-rabbit-liver-vx2-tumor-perfusion-and-comparative-analysis-through-immunohistochemisty
#11
Zhijun Liu, Xueying Long, Hui Liu
To investigate the correlations among total liver CT perfusion parameters, unpaired arteries (UAs) and microvessel area (MVA) in a rabbit liver VX2 tumor model, and to learn the tumoral angiogenesis condition and the mechanisms for perfusion imaging.
 Methods: Rabbits with or without the inoculated VX2 tumor in the liver underwent total liver CT perfusion imaging 2 weeks after the operation. Perfusion parameters included blood flow (BF), blood volume (BV), arterial liver perfusion (ALP), portal liver perfusion (PVP), hepatic perfusion index (HPI) for the tumor rim and the surrounding liver tissue...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28068108/transferability-and-adhesion-of-sol-gel-derived-crystalline-tio2-thin-films-to-different-types-of-plastic-substrates
#12
Natsumi Amano, Mitsuru Takahashi, Hiroaki Uchiyama, Hiromitsu Kozuka
Anatase thin films were prepared on various plastic substrates by our recently developed sol-gel transfer technique. The plastic substrates employed were polycarbonate (PC), poly(methyl methacrylate) (PMMA), polyethylene terephthalate (PET), polyethylene (PE), polypropylene (PP), polyether ether ketone (PEEK), and polyvinylidene chloride (PVDC). An Si(100) substrate was first coated with a polyimide (PI)/polyvinylpyrrolidone (PVP) mixture layer, and an alkoxide-derived titania gel film was deposited on it by spin-coating...
January 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28058760/fluorescence-based-logic-gate-for-sensing-of-ca-2-and-f-ions-using-pvp-crowned-chrysene-nanoparticles-in-aqueous-medium
#13
Prasad G Mahajan, G B Kolekar, Shivajirao R Patil
Polyvinyl pyrrolidone (PVP) crowned chrysene nanoparticles (CHYNPs) were prepared by using a reprecipitation method. Dynamic light scattering (DLS) and scanning electron microscope (SEM) studies indicate that the monodispersed spherical nanoparticles bear a negative charge on their surfaces. The bathochromic spectral shift in the UV-visible and fluorescence spectrum of CHYNPs from chrysene (CHY) in acetone solution supports the J- type aggregation of nanoparticles. The aggregation-induced enhanced emission of CHYNPs at 486 and 522 nm decreases by increasing the concentration of the Ca(2)(+) ion solution...
January 5, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28057095/-comparison-of-curative-effect-and-prognosis-analysis-of-patients-with-spinal-metastases-treated-by-percutaneous-vertebroplasty-combined-with-postoperative-radiotherapy-and-radiotherapy-alone
#14
X Y Cao, Y S Liu, M X Lei, S B Liu, S G Zhou, Y C Cao, W G Jiang
Objective: To evaluate the efficacy of percutaneous vertebroplasty(PVP) combined with postoperative radiotherapy and radiotherapy alone in the treatment of spinal metastatic tumors and to evaluate the prognostic factors for survival. Methods: From December 2011 to December 2015, according to the choice of treatment, patients in group A(60 cases) were treated with PVP combined with postoperative radiotherapy and those in group B(50 cases) underwent radiotherapy alone, age, sex, primary tumor type , and other basic characteristics were analyzed in both groups in department of orthopedics and radiotherapy department, 307 Hospital of the People's Liberation Army...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28053646/comparison-of-three-genomic-dna-extraction-methods-to-obtain-high-dna-quality-from-maize
#15
Amani Abdel-Latif, Gamal Osman
BACKGROUND: The world's top three cereals, based on their monetary value, are rice, wheat, and corn. In cereal crops, DNA extraction is difficult owing to rigid non-cellulose components in the cell wall of leaves and high starch and protein content in grains. The advanced techniques in molecular biology require pure and quick extraction of DNA. The majority of existing DNA extraction methods rely on long incubation and multiple precipitations or commercially available kits to produce contaminant-free high molecular weight DNA...
2017: Plant Methods
https://www.readbyqxmd.com/read/28050711/torsemide-fast-dissolving-tablets-development-optimization-using-box-bhenken-design-and-response-surface-methodology-in-vitro-characterization-and-pharmacokinetic-assessment
#16
Ahmed A El-Shenawy, Mahmoud M Ahmed, Heba F Mansour, Saleh Abd El Rasoul
The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD was selected for formulation of torsemide FDTs by direct compression method...
January 3, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28049054/monodisperse-raspberry-like-multihollow-polymer-ag-nanocomposite-microspheres-for-rapid-catalytic-degradation-of-methylene-blue
#17
Qiong Tian, Xiaojing Yu, Lifeng Zhang, Demei Yu
Raspberry-like multihollow polymer microspheres were prepared by seeded swelling polymerization and decorated with silver nanoparticles (AgNPs) in the presence of polyvinylpyrrolidone (PVP) which acted as both reducing and stabilizing agent. Formation mechanism of the raspberry-like multihollow microsphere was discussed on the basis of water absorption of sulfonated groups in the seeded swelling polymerization. Effects of weight ratio of sodium 4-vinylbenzenesulfonate to styrene (NaSS/St) of the seed particles, the concentration of PVP and [Ag(NH3)2](+) ions on the properties of polymer/Ag nanocomposite microspheres were investigated by microscopic observation, nitrogen adsorption/desorption isotherms, UV-vis absorption spectra, X-ray diffraction patterns and thermogravimetric analysis...
December 23, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28046614/tu-h-campus-iep2-01-quantitative-evaluation-of-propeller-dwi-using-qiba-diffusion-phantom
#18
J Yung, H Ai, H Liu, R Stafford
PURPOSE: The purpose of this study is to determine the quantitative variability of apparent diffusion coefficient (ADC) values when varying imaging parameters in a diffusion-weighted (DW) fast spin echo (FSE) sequence with Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) k-space trajectory. METHODS: Using a 3T MRI scanner, a NIST traceable, quantitative magnetic resonance imaging (MRI) diffusion phantom (High Precision Devices, Inc, Boulder, Colorado) consisting of 13 vials filled with various concentrations of polymer polyvinylpyrrolidone (PVP) in aqueous solution was imaged with a standard Quantitative Imaging Biomarkers Alliance (QIBA) DWI spin echo, echo planar imaging (SE EPI) acquisition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044238/vaporize-anatomically-vaporize-or-enucleate-the-prostate-the-flexible-use-of-the-greenlight-laser
#19
Luca Cindolo, Lorenzo Ruggera, Paolo Destefanis, Claudio Dadone, Giovanni Ferrari
PURPOSES: GreenLight laser has gained increasing acceptance as a less invasive treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (BPH/LUTS). Three surgical options were developed: standard photovaporization (PVP), anatomical PVP and GreenLight enucleation of prostate (GreenLEP); however, literature lacks a direct comparison among the procedures. Aim of the present study is to compare the three techniques in a multicentre series of patients. METHODS: Data were collected from consecutive patients with indication to surgical management of BPH/LUTS in five institutions...
January 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28043133/long-term-physical-stability-of-pvp-and-pvpva-amorphous-solid-dispersions
#20
Kristin Lehmkemper, Samuel O Kyeremateng, Oliver Heinzerling, Matthias Degenhardt, Gabriele Sadowski
The preparation of amorphous solid dispersion (ASD) formulations is a promising strategy to improve the bioavailability of an active pharmaceutical ingredient (API). By dissolving the API in a polymer it is stabilized in its amorphous form, which usually shows higher water solubility than its crystalline counterpart. To prevent recrystallization, the long-term physical stability of ASD formulations is of big interest. In this work, the solubility of the APIs acetaminophen and naproxen in the excipient polymers poly(vinylpyrrolidone) (PVP K25) and poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64) was calculated with three models: the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT), the Flory-Huggins model (FH), and an empirical model (Kyeremateng et al...
January 3, 2017: Molecular Pharmaceutics
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