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https://www.readbyqxmd.com/read/28335227/synthesis-of-ball-like-ag-nanorod-aggregates-for-surface-enhanced-raman-scattering-and-catalytic-reduction
#1
Wenjing Zhang, Yin Cai, Rui Qian, Bo Zhao, Peizhi Zhu
In this work, ball-like Ag nanorod aggregates have been synthesized via a simple seed-mediated method. These Ag mesostructures were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), and X-ray diffraction (XRD). Adding a certain amount of polyvinyl pyrrolidone (PVP) can prolong its coagulation time. These Ag nanorod aggregates exhibit effective SERS effect, evaluated by Rhodamine 6G (R6G) and doxorubicin (DOX) as probe molecules...
May 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335201/size-and-shape-dependent-antibacterial-studies-of-silver-nanoparticles-synthesized-by-wet-chemical-routes
#2
Muhammad Akram Raza, Zakia Kanwal, Anum Rauf, Anjum Nasim Sabri, Saira Riaz, Shahzad Naseem
Silver nanoparticles (AgNPs) of different shapes and sizes were prepared by solution-based chemical reduction routes. Silver nitrate was used as a precursor, tri-sodium citrate (TSC) and sodium borohydride as reducing agents, while polyvinylpyrrolidone (PVP) was used as a stabilizing agent. The morphology, size, and structural properties of obtained nanoparticles were characterized by scanning electron microscopy (SEM), UV-visible spectroscopy (UV-VIS), and X-ray diffraction (XRD) techniques. Spherical AgNPs, as depicted by SEM, were found to have diameters in the range of 15 to 90 nm while lengths of the edges of the triangular particles were about 150 nm...
April 15, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334805/hair-testing-for-drugs-of-abuse-and-new-psychoactive-substances-in-a-high-risk-population
#3
Alberto Salomone, Joseph J Palamar, Enrico Gerace, Daniele Di Corcia, Marco Vincenti
Hundreds of new psychoactive substances (NPS) have emerged in the drug market over the last decade. Few drug surveys in the USA, however, ask about use of NPS, so prevalence and correlates of use are largely unknown. A large portion of NPS use is unintentional or unknown as NPS are common adulterants in drugs like ecstasy/Molly, and most NPS are rapidly eliminated from the body, limiting efficacy of urine, blood and saliva testing. We utilized a novel method of examining prevalence of NPS use in a high-risk population utilizing hair-testing...
March 4, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28333023/hyaluronan-binding-system-for-sperm-selection-enhances-pregnancy-rates-in-icsi-cycles-associated-with-male-factor-infertility
#4
Renata F Erberelli, Renato M Salgado, Dirceu H Mendes Pereira, Philip Wolff
OBJECTIVES: The aim of the present study was to compare two procedures for sperm selection in ICSI cycles - conventional morphology sperm selection (ICSI-PVP) and chemical selection through Hyaluronan-treated petri dishes (PICSI), when male factor was associated. METHODS: The evaluated parameters were semen quality, fertilization and cleavage rates, chemical and clinical pregnancy rates, as well as abortion rate. Fifty-six ICSI cycles were included in this report, 19 cycles using PICSI and 37 using conventional ICSI...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28330268/antimicrobial-activity-of-pvp-coated-silver-nanoparticles-synthesized-by-lysinibacillus-varians
#5
Divya Bhatia, Ashwani Mittal, Deepak Kumar Malik
Emergence of resistant microbes to conventional antibiotics and increased emphasis on health-care costs has raised the concern for the development of new effective antimicrobial reagents. Silver nanoparticles being an excellent broad-spectrum antibacterial agent could be considered as a suitable alternative for existing antibiotic. This study demonstrates the extra-cellular synthesis of stable silver nanoparticles using supernatant of Lysinibacillus varians. The synthesized silver nanoparticles were characterized by using UV-visible spectrum analysis, X-ray diffraction, Transmission electron microscopy (TEM) and FT-IR analysis...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330131/an-efficient-protocol-for-isolation-of-inhibitor-free-nucleic-acids-even-from-recalcitrant-plants
#6
Mohammad Hossein Rezadoost, Mojtaba Kordrostami, Hassan Hassani Kumleh
For fast and easy isolation of inhibitor-free genomic DNA even from the toughest plant leaf samples, including those high in polyphenols and polysaccharides, a protocol has been developed. To prevent the solubility of polysaccharides in the DNA extract, high salt concentration (1.4 M) was used in the extraction buffer. Polyvinylpyrrolidone (PVP) was used for the removal of polyphenols as polymerase chain reaction (PCR) inhibitors. Proteins like various enzymes were degraded by proteinase K and removed by centrifugation from plant extracts during the isolation process resulting in pure DNA and RNA ready to use in downstream applications including PCR, quantitative polymerase chain reaction (qPCR), ligation, restriction and sequencing...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#7
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
March 15, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28325154/the-behavioral-profile-of-methylenedioxypyrovalerone-mdpv-and-%C3%AE-pyrrolidinopentiophenone-pvp-a-systematic-review
#8
Cornel N Stanciu, Thomas M Penders, Samantha A Gnanasegaram, Elvin Pirapakaran, Juvraj S Padda, Jeeven S Padda
BACKGROUND: New psychoactive substances are emerging at an alarming rate. With novel structures and properties they produce unique behavioral characteristics during intoxication. Synthetic cathinones are some of the most common. More and more are presenting to emergency departments due to consequences of use. Aside from isolated reports, little is known about these compounds. OBJECTIVE: Here we review literature pertaining to two common synthetic cathinones, MDPV and alphaPVP, and correlate clinically with guidance on management of intoxications...
March 21, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28324691/comparison-of-three-different-types-of-cilostazol-loaded-solid-dispersion-physicochemical-characterization-and-pharmacokinetics-in-rats
#9
Omer Mustapha, Kyung Soo Kim, Shumaila Shafique, Dong Shik Kim, Sung Giu Jin, Youn Gee Seo, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi
The aim of this research was to compare three different types of cilostazol-loaded solid dispersion system including solvent-evaporated, solvent-wetted and surface-attached solid dispersion. The effect of polymers and surfactants on the aqueous solubility of cilostazol was investigated, leading to the selection of polyvinylpyrrolidone (PVP) and sodium lauryl sulphate (SLS). Employing a spray-drying technique, numerous surface-attached, solvent-evaporated and solvent-wetted solid dispersions were prepared with various amounts PVP and SLS using water, 90% ethanol and acetone, respectively...
March 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28323701/cost-effectiveness-analysis-of-percutaneous-vertebroplasty-for-osteoporotic-compression-fractures
#10
Tomoyuki Takura, Misako Yoshimatsu, Hiroki Sugimori, Kenji Takizawa, Yoshiyuki Furumatsu, Hirotaka Ikeda, Hiroshi Kato, Yukihisa Ogawa, Shingo Hamaguchi, Atsuko Fujikawa, Toshihiko Satoh, Yasuo Nakajima
STUDY DESIGN: Single-center, single-arm, prospective time-series study. OBJECTIVE: To assess the cost-effectiveness and improvement in quality of life (QOL) of percutaneous vertebroplasty (PVP). SUMMARY OF BACKGROUND DATA: PVP is known to relieve back pain and increase QOL for osteoporotic compression fractures. However, the economic value of PVP has never been evaluated in Japan where universal health care system is adopted. METHODS: We prospectively followed up 163 patients with acute vertebral osteoporotic compression fractures, 44 males aged 76...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323199/acute-toxicity-bioaccumulation-and-effects-of-dietary-transfer-of-silver-from-brine-shrimps-exposed-to-pvp-pei-coated-silver-nanoparticles-to-zebrafish
#11
José María Lacave, Álvaro Fanjul, Eider Bilbao, Nerea Gutierrez, Irantzu Barrio, Inmaculada Arostegui, Miren P Cajaraville, Amaia Orbea
The extensive use and release to the aquatic environment of silver nanoparticles (NPs) could lead to their incorporation into the food web. Brine shrimp larvae of 24h showed low sensitivity to the exposure to PVP/PEI-coated Ag NPs (5nm), with EC50 values at 24h of 19.63mg Ag L(-1), but they significantly accumulated silver after 24h of exposure to 100μg L(-1) of Ag NPs. Thus, to assess bioaccumulation and effects of silver transferred by the diet in zebrafish, brine shrimp larvae were exposed to 100ng L(-1) of Ag NPs as an environmentally relevant concentration or to 100μg L(-1) as a potentially effective concentration and used to feed zebrafish for 21days...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28323118/mixed-poly-vinyl-pyrrolidone-based-drug-loaded-nanomicelles-shows-enhanced-efficacy-against-pancreatic-cancer-cell-lines
#12
Anisha Veeren, Archana Bhaw-Luximon, Debabrata Mukhopadhyay, Dhanjay Jhurry
We report in this paper on the enhanced efficacy of a physical mixture of two single anti-cancer loaded nanomicelles against PANC-1 and BxPC-3. Poly(vinyl pyrrolidone-b-polycaprolactone) (PVP-b-PCL) and poly(vinyl pyrrolidone-b-poly(dioxanone-co-methyl dioxanone)) (PVP-b-P(DX-co-MeDX)) were synthesized and successfully loaded with various anti-cancer drugs - gemcitabine (GEM), doxorubicin.HCl (DOX.HCl), doxorubicin.NH2 (DOX), 5-fluorouracil (5-FU) and paclitaxel (PTX). Spherical micelles of size 160-477 nm were obtained as characterized by DLS while sizes determined by TEM were in the range 140-250 nm...
March 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28322942/an-insight-into-the-impact-of-polymers-on-the-hydrate-conversion-of-olanzapine-form-i-in-aqueous-suspensions
#13
Maria C Paisana, Martin A Wahl, João F Pinto
The potential of PEG, PVP and HPC to inhibit the hydration of olanzapine (OLZ) in aqueous environments was assessed. OLZ Form I (OLZ) suspended in water (A) or in aqueous polymer solutions (2, 0.2, 0.02 and 0.002%) [PEG6,000 (B), PEG40,000 (C), HPC-LF (D) or PVP-K30 (E)]. Filtered samples were analyzed by different techniques (XRPD, FTIR, DSC, (1)H-NMR). OLZ hydration showed to be faster in water than in PEG solutions, regardless of the polymer MW. OLZ in D and E suspensions remained anhydrous at concentrations of 2-0...
March 16, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28322164/solubilization-and-enhancement-of-ex-vivo-vaginal-delivery-of-progesterone-using-solid-dispersions-inclusion-complexes-and-micellar-solubilization
#14
Abeer S Hassan, Ghareb M Soliman, Mona M El-Mahdy, Gamal El-Din A El-Gindy
Progesterone (PG), a natural female sex hormone is used clinically in menopausal hormone replacement therapy and to control reproductive functions. Its very limited aqueous solubility of 7 µg/ml results in reduced oral bioavailability and low patient compliance when administered in high doses. The aim of this study was to enhance PG aqueous solubility and vaginal delivery using solid dispersion, inclusion complex and micellar solubilization techniques. PG solid dispersions and inclusion complexes were prepared by solvent evaporation method using different polymers, such as cyclodextrins, polyvinyl pyrrolidone (PVP), poly (ethylene glycol) 6000, Pluronic® F-127 and Pluronic® F-68...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28317227/trends-in-the-surgical-treatment-of-benign-prostatic-hyperplasia-in-a-tertiary-hospital
#15
Darren Ow, Nathan Papa, Marlon Perera, Peter Liodakis, Shomik Sengupta, Stephen Clarke, Damien M Bolton, Nathan Lawrentschuk
BACKGROUND: To assess current treatment trends and perioperative outcomes of transurethral resection of the prostate (TURP) and photoselective vaporization of the prostate (PVP) in a tertiary institution. METHODS: We prospectively collected a database of all patients undergoing TURP and PVP for benign prostatic hyperplasia (BPH) at a tertiary hospital between January 2011 and December 2013. Patient characteristics such as length of stay, readmission, anticoagulation status, American Society of Anesthesiologists (ASA) score and need for blood transfusion were recorded and analysed...
March 19, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28314142/responses-to-silver-nanoparticles-and-silver-nitrate-in-a-battery-of-biomarkers-measured-in-coelomocytes-and-in-target-tissues-of-eisenia-fetida-earthworms
#16
Curieses Silvana Patricia, García-Velasco Nerea, Urionabarrenetxea Erik, Sáenz María Elena, Bilbao Eider, Di Marzio Walter Darío, Soto Manu
The current use and development of applications with silver nanoparticles (Ag NPs) could lead to potential inputs of these NPs to soils. Consequently, it is crucial to understand the ecotoxicological risks posed by Ag NPs in the terrestrial compartment. In the present investigation, the effects produced by PVP-PEI coated Ag NPs were assessed in Eisenia fetida earthworms in comparison with the soluble form (AgNO3). Earthworms were exposed for 1, 3 and 14 days to a range of sublethal concentrations of Ag (0, 0...
March 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28304113/partitioning-of-nanoparticle-originated-dissolved-silver-in-natural-and-artificial-sediments
#17
Juho E Rajala, Eeva-Riikka Vehniäinen, Ari Väisänen, Jussi V K Kukkonen
Sediments are believed to be a major sink for the silver nanoparticles (AgNP) in the aquatic environment, but there is a lack of knowledge about the environmental effects and behaviour of AgNP in sediments. The release of highly toxic Ag(+) through dissolution of AgNP is one mechanism leading to toxic effects in sediments. We applied an ultrasound-assisted sequential extraction method to evaluate the dissolution of AgNP and to study the partitioning of dissolved Ag in sediments. Ag was spiked into artificial (AS) and 2 natural sediments (HS, KS) as silver nitrate (AgNO3 ), uncoated AgNP (uc-AgNP), or polyvinylpyrrolidone-coated AgNP (PVP-AgNP)...
March 17, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28299922/fabrication-of-electrospun-mucoadhesive-membranes-for-therapeutic-applications-in-oral-medicine
#18
Martin E Santocildes-Romero, Lucie Hadley, Katharina H Clitherow, Jens Hansen, Craig Murdoch, Helen E Colley, Martin Thornhill, Paul V Hatton
Oral mucosal lesions are related to several etiologies including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes or gels containing suitable drugs. However, topical medications may be relatively ineffective as they are removed rapidly from oral surfaces, limiting drug contact times. Systemic medications might be more effective, but are associated with unacceptable off-target side effects...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28293871/greenlight-laser-photoselective-vaporization-of-the-prostate-for-treatment-of-benign-prostate-hyperplasia-lower-urinary-tract-symptoms-in-patients-with-different-post-void-residual-urine
#19
Fei Luo, Hong-Hong Sun, Yan-Hui Su, Zhi-Hua Zhang, Ya-Shen Wang, Zhen Zhao, Jian Li
The purpose of this study is to assess the safety and efficacy of GreenLight laser photoselective vaporization of the prostate (PVP) for the treatment of benign prostate hyperplasia/lower urinary tract symptoms (BPH/LUTS) in patients with different post-void residual urine (PVR). BPH/LUTS patients treated with PVP from January 2014 to January 2016 were enrolled in the present study. All patients were divided into PVR > 50, 50 ≤ PVR < 400, and PVR ≥ 400 ml groups, and standard general and urological methods for BPH/LUTS were carried out...
March 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28293625/an-imaging-and-histological-study-on-intrahepatic-microvascular-passage-of-contrast-materials-in-rat-liver
#20
Qian Xia, Yuanbo Feng, Ting Yin, Yewei Liu, Guozhi Zhang, Jianjun Liu, Linjun Tong, Robin Willemyns, Jie Yu, Raymond Oyen, Gang Huang, Yicheng Ni
Background. Lipiodol has been applied for decades in transarterial chemoembolization to treat liver malignancies, but its intrahepatic pathway through arterioportal shunt (APS) in the liver has not been histologically revealed. This rodent experiment was conducted to provide evidence for the pathway of Lipiodol delivered through the hepatic artery (HA) but found in the portal vein (PV) and to elucidate the observed unidirectional APS. Methods. Thirty rats were divided into 5 groups receiving systemic or local arterial infusion of red-stained iodized oil (RIO) or its hydrosoluble substitute barium sulfate suspension (BSS), or infusion of BSS via the PV, monitored by real-time digital radiography...
2017: BioMed Research International
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