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https://www.readbyqxmd.com/read/29164830/changes-in-erectile-function-after-photoselective-vaporization-of-the-prostate-with-a-120-w-greenlight-high-performance-system-laser-2-year-follow-up
#1
Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
PURPOSE: To evaluate the impact of photoselective vaporization of the prostate (PVP) with a 120-W GreenLight high-performance system on erectile function in a 2-year follow-up study. MATERIALS AND METHODS: One hundred seventy-seven patients who underwent PVP during 2008 to 2012 were analyzed retrospectively. The patients were divided into 5 groups according to their preoperative 5-item International Index of Erectile Function (IIEF-5) scores: Group I (IIEF-5: 5~7, n=28), II (IIEF-5: 8~11, n=47), III (IIEF-5: 12~16, n=43), IV (IIEF-5: 17~21, n=34), and V (IIEF-5: 22~25, n=25)...
November 16, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29161509/variation-in-the-supersaturation-and-phase-behavior-of-ezetimibe-amorphous-solid-dispersions-upon-dissolution-in-different-biorelevant-media
#2
Ahmed Elkhabaz, Sreya Sarkar, Janny K Dinh, Garth J Simpson, Lynne S Taylor
The delivery of poorly water-soluble drugs using amorphous solid dispersions (ASDs) has been widely acknowledged as a promising strategy for enhancing oral bioavailability. Upon dissolution, ASDs have accelerated dissolution rates and yield supersaturated solutions leading to higher apparent solubilities. Understanding the complex phase behavior of ASDs during dissolution is crucial for developing an effective formulation. Since the absorption of a lipophilic, high permeability drug is determined primarily by the intraluminal dissolution process and the final concentration achieved, there is a need for evaluation in biorelevant dissolution media that simulate both fasting and fed gastrointestinal states...
November 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29159985/synthesized-tissue-equivalent-dielectric-phantoms-using-salt-and-polyvinylpyrrolidone-solutions
#3
Carlotta Ianniello, Jacco A de Zwart, Qi Duan, Cem M Deniz, Leeor Alon, Jae-Seung Lee, Riccardo Lattanzi, Ryan Brown
PURPOSE: To explore the use of polyvinylpyrrolidone (PVP) for simulated materials with tissue-equivalent dielectric properties. METHODS: PVP and salt were used to control, respectively, relative permittivity and electrical conductivity in a collection of 63 samples with a range of solute concentrations. Their dielectric properties were measured with a commercial probe and fitted to a 3D polynomial in order to establish an empirical recipe. The material's thermal properties and MR spectra were measured...
November 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29156424/blink-reflex-under-external-emotional-stimuli-in-bipolar-i-and-ii-disorders
#4
Qisha Zhu, Jiawei Wang, Hongying Fan, Guorong Ma, Bingren Zhang, Chanchan Shen, Wei Wang
Bipolar disorder types I (BD I) and II (BD II) might present different cortico-brainstem circuit dysfunctions under external emotions, which might be reflected by the blink reflex. We therefore invited 32 BD I and 23 BD II patients, and 46 healthy volunteers to answer the Mood Disorder Questionnaire, the Hypomania Checklist-32, and the Plutchik - van Praag Depression inventory, and to undergo the blink reflex test under external emotions (emotional pictures plus sounds) of Disgust, Erotica, Fear, Happiness, and Sadness...
November 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29155229/particle-agglomeration-of-chitosan-magnesium-aluminum-silicate-nanocomposites-for-direct-compression-tablets
#5
Rapee Khlibsuwan, Thaned Pogjanyakul
Exfoliated nanocomposites of chitosan-magnesium aluminum silicate (CS-MAS) particles are characterized by good compressibility but poor flowability. Thus, the aims of this study were to investigate agglomerates of CS-MAS nanocomposites prepared using the agglomerating agents water, ethanol, or polyvinylpyrrolidone (PVP) for flowability enhancement and to evaluate the agglomerates obtained as direct compression fillers for tablets. The results showed that the addition of agglomerating agents did not affect crystallinity, but slightly influenced thermal behavior of the CS-MAS nanocomposites...
November 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29154916/acute-intravenous-exposure-to-silver-nanoparticles-during-pregnancy-induces-particle-size-and-vehicle-dependent-changes-in-vascular-tissue-contractility-in-sprague-dawley-rats
#6
A K Vidanapathirana, L C Thompson, M Herco, J Odom, S J Sumner, T R Fennell, J M Brown, C J Wingard
The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110nm AgNP (700μg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24h post-exposure...
November 14, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29153719/platinum-silver-alloyed-octahedral-nanocrystals-as-electrocatalyst-for-methanol-oxidation-reaction
#7
Jiajing Li, Heng Rong, Xiaowei Tong, Peng Wang, Tao Chen, Zhenghua Wang
Previous reports show that the {1 1 1} crystal facets of Pt-based nanocrystal catalysts are highly active for the electrooxidation of methanol. In this work, platinum-silver (Pt-Ag) alloy octahedral nanocrystals with exposed {1 1 1} facets are successfully synthesized through a one-pot, wet-chemical route. The growth mechanism of octahedral nanocrystals can be attributed to the stabilization of {1 1 1} facets by PVP. The electrocatalytic performances of the Pt-Ag octahedral nanocrystals with different Pt/Ag ratio and commercial Pt/C are studied...
November 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29148696/the-epidermal-penetration-of-gold-nanoparticles-and-its-underlying-mechanism-based-on-human-reconstructed-3d-episkin-tm-model
#8
Fang Hao, Xiaoting Jin, Qian S Liu, Qunfang Zhou, Guibin Jiang
Nanomaterials are widely used in diverse aspects and their translocation behavior through the skin would be helpful in understanding the corresponding exposure risks. To reveal how surface functionalization of nanoparticles influence the skin penetration, three kinds of gold nanoparticles (GNPs) with negatively, neutrally and positively charged surfaces, i.e. cetyltrimethyl ammonium bromide-coated GNPs (CTAB@GNP), polyvinyl pyrrolidone-coated GNPs (PVP@GNP), and citrate-coated GNPs (Citrate@GNP), were studied using human reconstructed 3D EpiskinTM model...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29147871/an-optimized-and-feasible-preparation-technique-for-the-industrial-production-of-hydrogel-patches
#9
Wei-Ze Li, Wen-Xia Han, Xu-Liang Hao, Ning Zhao, Xi-Feng Zhai, Li-Bin Yang, Shu-Miao He, Yu-Chuan Cheng, Han Zhang, Li-Na Fu, Yan Zhang, Ze Liang
For hydrogel patches, the laboratory tests could not fully reveal the existing problems of full scale of industrial production, and there are few studies about the preparation technique for the industrial manufacturing process of hydrogel patches. So, the purpose of this work was to elucidate the effects of mainly technological operation and its parameters on the performance of hydrogel patches at the industrial-scale production. The results revealed the following: (1) the aqueous phase was obtained by polyvinylpyrrolidone (PVP) along with tartaric acid dissolved in purified water, then feeding this into a vacuum mixer as a whole in one batch, thus extended the crosslinking reaction time of hydrogel paste (matrix) and allowed the operation of coating/cutting-off to be carried out easily, and there was no permeation of backing layer; (2) the gel strength of the hydrogel patches increased with the increase of working temperature, however, once the temperature exceeded 35 ± 2 °C, the hydrogel paste would lose water severely and the resultant physical crosslinking structure which has lower gel/cohesive strength would easily bring gelatinization/residues during application; (3) the relative humidity (RH) of the standing-workshop was dynamically controlled (namely at 35 ± 2 °C, keeping the RH at 55 ± 5% for 4 days, then 65 ± 5% for 2 days), which would make patches with satisfactory characteristics such as better flexibility, higher adhesive force, smooth flat matrix surface, and without gelatinization/residues and warped edge during the using process; (4) the aging of the packaged hydrogel patches was very sensitive to storage temperature, higher temperature, higher gel strength and lower adhesiveness...
November 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29146094/is-balloon-kyphoplasty-a-better-treatment-than-percutaneous-vertebroplasty-for-chronic-obstructive-pulmonary-disease-copd-patients-with-osteoporotic-vertebral-compression-fractures-ovcfs
#10
Xinjie Wu, Xiangsheng Tang, Mingsheng Tan, Ping Yi, Feng Yang
BACKGROUND: Although several studies reported that Balloon kyphoplasty (BK) or percutaneous vertebroplasty (PVP) could improve pulmonary functions, there is no study to compare the efficacy and safety of 2 procedures in COPD patients with osteoporotic vertebral compression fractures (OVCFs) and investigate the reason why they could improve pulmonary functions. METHOD: Two procedures, including BK and PVP were performed in 61 COPD patients with single-level OVCFS...
November 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29137771/solvent-effect-in-sonochemical-synthesis-of-metal-alloy-nanoparticles-for-use-as-electrocatalysts
#11
Celest U Okoli, Kurian A Kuttiyiel, Jesse Cole, J McCutchen, Hazem Tawfik, Radoslav R Adzic, Devinder Mahajan
Nanomaterials are now widely used in the fabrication of electrodes and electrocatalysts. Herein, we report a sonochemical study of the synthesis of molybdenum and palladium alloy nanomaterials supported on functionalized carbon material in various solvents: hexadecane, ethanol, ethylene glycol, polyethylene glycol (PEG 400) and Ionic liquids (ILs). The objective was to identify simple and more environmentally friendly design and fabrication methods for nanomaterial synthesis that are suitable as electrocatalysts in electrochemical applications...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137739/employment-of-ultrasonic-irradiation-for-production-of-poly-vinyl-pyrrolidone-modified-alpha-manganese-dioxide-nanocomposites-morphology-thermal-and-optical-characterization
#12
Shadpour Mallakpour, Amir Abdolmaleki, Hashem Tabebordbar
This work explains the production, morphology, and features of novel nanocomposite (NC) established on poly(vinyl pyrrolidone) (PVP) as polymer background and modified alpha manganese dioxide (α-MnO2) nanorod (NR) asan efficient filler. At first, one-dimensional α-MnO2 nanorods (NRs) were produced by a hydrothermal technique and then they were amended with stearic acid (SA) by a solvothermal process. In following, the NCs were made by adding different volumes of α-MnO2-SA NR (1, 3 and 5wt%) in the PVP matrix through ultrasonic irradiation as a green, low-cost, fast, and useful technique...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29135237/unveiling-the-susceptibility-of-functional-groups-of-polyethersulfone-polyvinylpyrrolidone-membranes-to-naocl-a-two-dimensional-correlation-spectroscopic-study
#13
Zhongbo Zhou, Guocheng Huang, Yi Xiong, Minghao Zhou, Shaoqing Zhang, Chuyang Y Tang, Fangang Meng
A clear understanding of membrane ageing process is essential for the optimization of chemical cleaning in membrane-based facilities. In this study, two-dimensional (2D) Fourier transformation infrared (FTIR) correlation spectroscopy (COS) analysis was firstly used to decipher the sequential order of functional group changes of NaOCl-aged polyethersulfone/polyvinylpyrrolidone (PES/PVP) membranes. The synchronous maps showed twelve major autopeaks in total. Based on the asynchronous maps, a similar ageing sequence of membrane groups was clearly identified at three pH (i...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29133233/freeze-drying-from-organic-co-solvent-systems-part-1-thermal-analysis-of-co-solvent-based-placebo-formulations-in-the-frozen-state
#14
Claudia Kunz, Sonja Schuldt-Lieb, Henning Gieseler
The use of co-solvent systems has been demonstrated to shorten lengthy freeze drying processes and improve the solubility and stability of certain active pharmaceutical ingredients. The goal of the present study was to evaluate the suitability of two thermal characterization techniques, differential scanning calorimetry and freeze dry microscopy, to identify an optimal co-solvent system. Binary mixtures of a co-solvent (tert-butanol, dimethyl sulfoxide, 1,4-dioxane, acetone or ethanol) and water were investigated...
November 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29132099/tribological-properties-of-pva-pvp-blend-hydrogels-against-articular-cartilage
#15
Yusuf Kanca, Piers Milner, Daniele Dini, Andrew A Amis
This research investigated in-vitro tribological performance of the articulation of cartilage-on- polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) blend hydrogels using a custom-designed multi-directional wear rig. The hydrogels were prepared by repeated freezing-thawing cycles at different concentrations and PVA to PVP fractions at a given concentration. PVA/PVP blend hydrogels showed low coefficient of friction (COF) values (between 0.12 ± 0.01 and 0.14 ± 0.02) which were closer to the cartilage-on-cartilage articulation (0...
October 25, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29131571/nanostructure-of-fully-injectable-hydrazone-thiosuccinimide-interpenetrating-polymer-network-hydrogels-assessed-by-small-angle-neutron-scattering-and-dstorm-single-molecule-fluorescence-microscopy
#16
Trevor Gilbert, Richard J Alsop, Mouhanad Babi, Jose Moran-Mirabal, Maikel C Rheinstadter, Todd Hoare
Herein, we comprehensively investigate the internal morphology of fully injectable IPNs prepared via co-extrusion of functionalized precursor polymer solutions based on thermoresponsive poly(N-isopropylacrylamide) and non-thermoresponsive poly(vinyl pyrrolidone) by reactive mixing using kinetically orthogonal hydrazone and thiosuccinimide cross-linking mechanisms. Small angle neutron scattering (SANS), probing both the full IPN as well as the individual constituent networks of the IPN using index matching, suggests a partially mixed internal structure characterized by PNIPAM-rich domains entrapped in a clustered PVP-rich phase...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29129570/poly-vinyl-pyrrolidone-lipid-based-hybrid-nanoparticles-for-anti-viral-drug-delivery
#17
K S Joshy, S Snigdha, George Anne, Kalarikkal Nandakumar, Pothen Laly A, Thomas Sabu
Zidovudine (AZT) is an antiviral drug with moderate solubility in water. It has limited application due to its short half life in vivo and consequent requirement for frequent administrations. To solve this problem, zidovudine loaded polyvinylpyrrolidone (PVP)/stearic acid (SA)-polyethylene glycol (PEG) nanoparticles (PSNPs) were developed.The hybrid nanoparticles were prepared by emulsification-solvent evaporation method. The physico chemical characterizations of the PSNPs was done by dynamic light scattering (DLS), transmission electron microscopy (TEM), and fourier transform infra-red spectroscopy (FT-IR)...
November 9, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29127610/pvp-va64-as-a-novel-release-modifier-for-sustained-release-mini-matrices-prepared-via-hot-melt-extrusion
#18
Yongcheng Li, Ming Lu, Chuanbin Wu
The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were extruded with 30% drug loading. The physical state of QF in extruded mini-matrices was characterized using differential scanning calorimetry, X-ray powder diffraction, and confocal Raman microscopy...
November 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29125471/carbon-dots-polyvinylpyrrolidone-hybrid-nanofibers-with-efficient-solid-state-photoluminescence-constructed-by-electrospinning-technique
#19
Yue Zhai, Xue Bai, Haining Cui, Jinyang Zhu, Wei Liu, Tianxiang Zhang, Biao Dong, Gencai Pan, Lin Xu, Shuang Zhang, Hongwei Song
Carbon dots (CDs) are the promising candidates for the application in the optoelectronic and biological areas due to their excellent photo-stability, unique photoluminescence, good biocompatibility, low toxicity and chemical inertness. However, the self-quenching of photoluminescence as they are dried into the solid-state dramatically limits their further applications. Therefore, realizing the efficient photoluminescence and large-scale production of CDs in the solid state is an urgent challenge. Herein, the solid-state hybrid nanofibers based on CDs and polyvinylpyrrolidone (PVP) are constructed through electrospinning process...
November 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#20
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
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