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https://www.readbyqxmd.com/read/27921158/long-term-outcome-of-percutaneous-alcohol-embolization-combined-with-percutaneous-vertebroplasty-in-aggressive-vertebral-hemangiomas-with-epidural-extension
#1
Kévin Premat, Frédéric Clarençon, Évelyne Cormier, Jugurtha Mahtout, Raphaël Bonaccorsi, Vincent Degos, Jacques Chiras
OBJECTIVES: To evaluate, on a long-term basis, the safety and effectiveness of percutaneous alcohol embolization (PAE) combined with percutaneous vertebroplasty (PVP) as a sole treatment for aggressive vertebral haemangiomas (AVHs) with epidural extension. METHODS: From 1996 to 2015, 26 consecutive patients (15 women [58%] and 11 men; mean age 51.8 years [range: 19-75 years]) underwent PAE combined with PVP (performed at day 15) for the treatment of 27 AVHs with epidural extension...
December 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27919702/design-of-pvp-va-s-630-based-tadalafil-solid-dispersion-to-enhance-the-dissolution-rate
#2
Jin-Seok Choi, Jeong-Sook Park
Tadalafil (TDF) is a Biopharmaceutics Classification System (BCS) class II drug; the efficacy thereof is critically limited by inherent poor water solubility. Solid dispersion (SD) techniques are widely used to improve the bioavailability of drugs that are poorly water-soluble. Herein, we used an SD technique to improve the solubility and in vitro dissolution rate of TDF; a solvent evaporation method was applied involving the use of hydrophilic carriers (PVP/VA S-630) and assistants (malic acid or meglumine)...
December 2, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27918999/effect-of-silver-nanoparticles-on-the-metabolic-rate-hematological-response-and-survival-of-juvenile-white-shrimp-litopenaeus-vannamei
#3
Karla Juarez-Moreno, Claudio Humberto Mejía-Ruiz, Fernando Díaz, Horacio Reyna-Verdugo, Ana Denisse Re, Edgar F Vazquez-Felix, Edna Sánchez-Castrejón, Josué D Mota-Morales, Alexey Pestryakov, Nina Bogdanchikova
White spot syndrome virus (WSSV) is highly lethal and contagious in shrimps; its outbreaks causes an economic crisis for aquaculture. Several attempts have been made to treat this disease; however, to date, there is no effective cure. Because of their antimicrobial activities, silver nanoparticles (AgNPs) are the most studied nanomaterial. Although the antiviral properties of AgNPs have been studied, their antiviral effect against viral infection in aquaculture has not been reported. The AgNPs tested herein are coated with polyvinylpyrrolidone (PVP) and possess multiple international certifications for their use in veterinary and human applications...
December 2, 2016: Chemosphere
https://www.readbyqxmd.com/read/27916870/saw-humidity-sensor-sensitivity-enhancement-via-electrospraying-of-silver-nanowires
#4
Farid Sayar Irani, Bahadir Tunaboylu
In this research, we investigated the influence of the surface coatings of silver nanowires on the sensitivity of surface acoustic wave (SAW) humidity sensors. Silver nanowires, with poly(vinylpyrrolidone) (PVP), which is a hydrophilic capping agent, were chemically synthesized, with an average length of 15 µm and an average diameter of 60 nm. Humidity sensors, with 433 MHz frequency dual-port resonator Rayleigh-SAW devices, were coated by silver nanowires (AgNWs) using the electrospray coating method. It was demonstrated that increasing thickness of coated AgNW on the surfaces of SAW devices results in increased sensitivity...
November 30, 2016: Sensors
https://www.readbyqxmd.com/read/27916403/stability-of-synthetic-cathinones-in-oral-fluid-samples
#5
Briana Miller, Jiyoung Kim, Marta Concheiro
Synthetic cathinones are new stimulant drugs derived from cathinone that have been sold as "legal highs" worldwide. These compounds can elicit powerful effects such as delusions, hallucinations as well as other potentially dangerous behavior. New analogs with varying effects and potencies are constantly introduced in the market to evade legislation, and they are not detected by routine screening and confirmation methods. Oral fluid is an alternative matrix of increasing interest in forensic toxicology. Its collection is non-invasive and easily supervised, and positive drug findings typically reflect recent drug exposure...
December 1, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27915573/solid-dispersions-enhance-solubility-dissolution-and-permeability-of-thalidomide
#6
Silvana A Barea, Cristiane B Mattos, Ariadne C C Cruz, Vitor C Chaves, Rafael N Pereira, Claudia M O Simões, Jadel M Kratz, Letícia S Koester
Thalidomide (THD) is a BCS class II drug with renewed and growing therapeutic applicability. Along with the low aqueous solubility, additional poor biopharmaceutical properties of the drug, i.e. chemical instability, high crystallinity and polymorphism, lead to a slow and variable oral absorption. In this view, we developed solid dispersions (SDs) containing THD dispersed in different self-emulsifying carriers aiming at an enhanced absorption profile for the drug. THD was dispersed in lauroyl macrogol-32 glycerides (Gelucire® 44/14) and α-tocopherol polyethylene glycol succinate (Kolliphor® TPGS),in the presence or absence of the precipitation inhibitor polyvinylpyrrolidone K30 (PVP K30), by means of the solvent method...
December 5, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27915006/predicting-optimal-wet-granulation-parameters-for-extrusion-spheronisation-of-pharmaceutical-pellets-using-a-mixer-torque-rheometer
#7
Manuel Kuhs, John Moore, Gayathri Kollamaram, Gavin Walker, Denise Croker
Mixer torque rheometry (MTR) was evaluated as a pre-production (pre-formulation and optimization) tool for predicting ideal liquid-to-solid ratios (L/S) for extrusion-spheronisation of a wide range of APIs using 10g formulations. APIs of low, medium and high solubility were formulated at low and high loadings (15 and 40% w/w, respectively) with PVP as binder (5%) and MCC as the major excipient. L/S corresponding to the maximum torque produced during wet massing in the MTR, L/S(maxT), was 0.8 for the low solubility APIs, which decreased to 0...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27908675/effect-of-polymers-in-moisture-sorption-and-physical-stability-of-polymorphic-olanzapine
#8
Maria C Paisana, Martin A Wahl, F João
The study aims to elucidate the transformations of anhydrous olanzapine Form I (OLZ FI) into the hydrate forms, when stored at a high relative humidity or suspended in an aqueous media, in the presence of polymers. OLZ FI and physical mixtures (3:1 and 1:1, as powders or compacts) of olanzapine with polyethylene glycol (PEG-6000), polyvinylpyrrolidone (PVP K25) and hydroxypropylcellulose (HPC-LF) were stored (75%RH/25°C, 75%RH/40°C and 93%RH/25°C) for 28days. OLZ FI and the physical mixtures were also suspended in water under stirring (200rpm/60min)...
November 28, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27908277/comparison-of-unilateral-and-bilateral-percutaneous-vertebroplasty-for-osteoporotic-vertebral-compression-fractures-a-systematic-review-and-meta-analysis
#9
Haolin Sun, Chunde Li
BACKGROUND: The aim of this meta-analysis is to examine the safety and effectiveness of unilateral percutaneous vertebroplasty (PVP) for treatment of osteoporotic vertebral compression fractures (OVCFs) compared with that of bilateral treatment. METHODS: The multiple databases including PubMed, Springer, EMBASE, OVID, and China Journal Full-text Database were adopted to search for relevant studies in English or Chinese, and full-text articles involving comparison of unilateral and bilateral PVP surgery were reviewed...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27905699/green-light-vaporization-of-the-prostate-pvp-is-it-an-adult-technique
#10
Aldo Brassetti, Cosimo De Nunzio, Nicolas Barry Delongchamps, Cristian Fiori, Francesco Porpiglia, Andrea Tubaro
INTRODUCTION: Intending to overcome Transurethral resection of the prostate (TURP) in terms of safety maintaining its efficacy profile, have led to the introduction of minimally invasive laser therapies to treat men with lower urinary tract symptoms (LUTS) secondary to Benign prostatic obstruction (BPO), each one with its unique properties. Aim of this review was to analyse and summarize all the existing data regarding the 180 W Xcelerated Performance System (XPS) Potoselective Vaporization of the Prostate (PVP)...
December 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27904217/percutaneous-vertebroplasty-guided-by-preoperative-computed-tomography-measurements
#11
Zhongbao Tan, Zhenhai Di, Xuequn Mao, Jian Zhang, Rong Zou, Qingqing Wang
BACKGROUND: Percutaneous vertebroplasty (PVP) is now widely performed to treat painful vertebral compression fractures. Previous researches have reported numerous advantages. However, it rarely reported that how to determine the feasibility of the unilateral or bilateral approach and how to decide the puncture angle, the skin insertion site before the procedure. The aim of this study was to discuss the feasibility of PVP using unilateral pedicular approach by the three-dimensional positioning of computed tomography (CT) image...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27901141/assembly-of-1d-nanofibers-into-a-2d-bi-layered-composite-nanofibrous-film-with-different-functionalities-at-the-two-layers-via-layer-by-layer-electrospinning
#12
Zijiao Wang, Qianli Ma, Xiangting Dong, Dan Li, Xue Xi, Wensheng Yu, Jinxian Wang, Guixia Liu
A two-dimensional (2D) bi-layered composite nanofibrous film assembled by one-dimensional (1D) nanofibers with trifunctionality of electrical conduction, magnetism and photoluminescence has been successfully fabricated by layer-by-layer electrospinning. The composite film consists of a polyaniline (PANI)/Fe3O4 nanoparticle (NP)/polyacrylonitrile (PAN) tuned electrical-magnetic bifunctional layer on one side and a Tb(TTA)3(TPPO)2/polyvinylpyrrolidone (PVP) photoluminescent layer on the other side, and the two layers are tightly combined face-to-face together into the novel bi-layered composite film of trifunctionality...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27899320/preparation-characterization-and-in-vivo-pharmacokinetic-study-of-pvp-modified-oleanolic-acid-liposomes
#13
Yan Liu, Xiao Luo, Xiaochao Xu, Nannan Gao, Xiaohong Liu
The primary purpose of the present study was to design and optimize a liposomal formulation of the poorly water-soluble drug oleanolic acid (OA) to improve its oral bioavailability, and prolong the duration of therapeutic drug level. Liposomes containing a soybean lecithin and cholesterol lipid bilayer, a protective hydrophilic polyvinylpyrrolidone-K30 (PVP-K30) coating, and a protective bile salt, sodium deoxycholate, were prepared by a thin-film dispersion method coupled with sonication. Several properties of the PVP-modified OA liposomes (PVPOALs), including surface morphology, particle size, zeta potential and entrapment efficiency were extensively characterized...
November 27, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27899200/-mucoadhesive-buccal-films-of-tramadol-for-effective-pain-management
#14
Xiao-Qin Li, Zhao-Ming Ye, Jian-Bing Wang, Cai-Rong Fan, Ai-Wu Pan, Cong Li, Ren-Bing Zhang
BACKGROUND AND OBJECTIVES: Tramadol hydrochloride is a centrally-acting synthetic opioid analgesic binding to specific opioid receptors. It is used in the management of chronic pain and is recommended as first line drug in the treatment of postoperative or orthopedic injury induced acute pain. The present work is designed to prepare and evaluate mucoadhesive buccal film of tramadol hydrochloride as a novel form of prolonged analgesia for patients with orthopedic injuries. METHODS: Buccal films of tramadol hydrochloride were prepared by solvent casting method...
November 26, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27899044/folic-acid-modified-and-functionalized-cus-nanocrystal-based-nanoparticles-for-combined-tumor-chemo-and-photothermal-therapy
#15
Zhu Xiali, Yingjie Zhang, Heqing Huang, Huijuan Zhang, Lin Hou, Zhenzhong Zhang
Recent studies have identified that CuS nanocrystal (CuS NCs) could be used as a new class of promising photo-thermal agents due to their excellent plasmonic absorption abilities in a wide near-infrared (NIR) region. However, most of nanocarriers lack target capacity for combining chemotherapy and photothermal therapy effects. Herein, we reported chitosan (CS)-encapsulated and folic acid (FA)-modified nanoparticles (NPs) simultaneously loading with functionalized CuS NCs and docetaxel (DTX) (FA-DTX-PVP/CuS-NPs)...
November 30, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27896614/modulatory-effects-of-zn-2-ions-on-the-toxicity-of-citrate-and-pvp-capped-gold-nanoparticles-towards-freshwater-algae-scenedesmus-obliquus
#16
V Iswarya, J B Johnson, Abhinav Parashar, Mrudula Pulimi, N Chandrasekaran, Amitava Mukherjee
Gold nanoparticles (GNPs) are widely used for medical purposes, both in diagnostics as well as drug delivery, and hence are prone to release and distribution in the environment. Thus, we have explored the effects of GNPs with two distinct surface capping (citrate and PVP), and three different sizes (16, 27, and 37 nm) at 0.01-, 0.1-, and 1-mg L(-1) concentrations on a predominant freshwater alga Scenedesmus obliquus in the sterile freshwater matrix. We have also investigated how an abundant metal ion from freshwater, i...
November 28, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27896377/self-administration-and-behavioral-economics-of-second-generation-synthetic-cathinones-in-male-rats
#17
S L Huskinson, J E Naylor, E A Townsend, J K Rowlett, B E Blough, K B Freeman
RATIONALE: Synthetic cathinones have become increasingly available as drugs of abuse. Distribution of these drugs is made possible by altering the chemical structures of prohibited cathinones and marketing them under misleading labels. Very little is known about the relative reinforcing effectiveness of new synthetic cathinones relative to known drugs of abuse. OBJECTIVE: We examined self-administration of three second-generation synthetic cathinones: alpha-pyrrolidinopentiophenone (alpha-PVP), 4-methyl-N-ethylcathinone (4-MEC), and 4-methyl-alpha-pyrrolidinopropiophenone (4-MePPP) relative to methamphetamine...
November 28, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27894021/toxicity-of-silver-ions-and-differently-coated-silver-nanoparticles-in-allium-cepa-roots
#18
Petra Cvjetko, Anita Milošić, Ana-Marija Domijan, Ivana Vinković Vrček, Sonja Tolić, Petra Peharec Štefanić, Ilse Letofsky-Papst, Mirta Tkalec, Biljana Balen
Silver nanoparticles (AgNPs) are the dominating nanomaterial in consumer products due to their well-known antibacterial and antifungal properties. To enhance their properties, different surface coatings may be used, which affect physico-chemical properties of AgNPs. Due to their wide application, there has been concern about possible environmental and health consequences. Since plants play a significant role in accumulation and biodistribution of many environmentally released substances, they are also very likely to be influenced by AgNPs...
November 25, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27886088/multi-functional-nanogels-for-tumor-targeting-and-redox-sensitive-drug-and-sirna-delivery
#19
Giorgia Adamo, Natascia Grimaldi, Simona Campora, Donatella Bulone, Maria Luisa Bondì, Mohamad Al-Sheikhly, Maria Antonietta Sabatino, Clelia Dispenza, Giulio Ghersi
(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27879294/cxcr2-is-involved-in-pulmonary-intravascular-macrophage-accumulation-and-angiogenesis-in-a-rat-model-of-hepatopulmonary-syndrome
#20
Xujiong Li, Yunxia Chen, Yongli Chang, Shufen Li, Zhongfu Zhao, HuiYing Zhang
Hepatopulmonary syndrome (HPS) is a lung complication in various liver diseases, with high incidence, poor prognosis and no effective non-surgical treatments in patients with hepatocirrhosis. Therefore, assessing HPS pathogenesis to explore proper therapy strategies is clinically relevant. In this study, male Sprague-Dawley rats underwent sham operation or common bile duct ligation (CBDL). Two weeks post-surgery, the following groups were setup for 2 weeks of treatment: Sham + normal saline, CBDL + CXCR2 antagonist SB225002, CBDL + TNF-α antagonist PTX, and CBDL + normal saline groups...
November 22, 2016: Clinical Science (1979-)
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