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Guangming Zeng, Lihua Zhang, Haoran Dong, Yaoning Chen, Jiachao Zhang, Yuan Zhu, Yujie Yuan, Yankai Xie, Wei Fang
Polyvinylpyrrolidone coated silver nanoparticles (PVP-AgNPs) were applied at different concentrations to reduce total nitrogen (TN) losses and the mechanisms of nitrogen bio-transformation were investigated in terms of the nitrogen functional enzymes and genes. Results showed that mineral N in pile 3 which was treated with AgNPs at a concentration of 10 mg/kg compost was the highest (6.58 g/kg dry weight (DW) compost) and the TN loss (47.07%) was the lowest at the end of composting. Correlation analysis indicated that TN loss was significantly correlated with amoA abundance...
December 29, 2017: Bioresource Technology
Giovanna C R M Schver, Dajun D Sun, Salvana P M Costa, Keyla E R Silva, Jamerson F Oliveira, Larissa Araujo Rolim, Mônica Camelo Pessôa de Azevedo Albuquerque, André de Lima Aires, Maria do Carmo A Lima, Ivan R Pitta, Ping I Lee, Pedro J Rolim-Neto
Drug candidate LPSF/FZ4 with promising schistosomicidal properties in vitro was previously synthesized. However, LPSF/FZ4 has limited aqueous solubility (<1 μg/mL), leading to ineffective dissolution and, therefore, no meaningful in vivo comparative studies could be pursued. This study was aimed to develop a proper amorphous solid dispersion (SD) to enhance the solubility and dissolution rate of LPSF/FZ4 such that its biological activity could be investigated. To better understand its physiological behavior, the pKa of LPSF/FZ4, a monoprotic weak acid with NH group at the imidazolidine ring, was first determined to be 8...
January 10, 2018: European Journal of Pharmaceutical Sciences
C Lanchon, G Fiard, J-A Long, V Arnoux, D Carnicelli, Q Franquet, D Poncet, E Bey, J-B Lefrancq, S Grisard, N Peilleron, N Terrier, B Boillot, J-J Rambeaud, J-L Descotes, C Thuillier
INTRODUCTION: GreenLight photoselective vaporisation of the prostate (PVP) offers an endoscopic alternative to open prostatectomy (OP) for treatment of large adenomas. This study compares long-term functional outcome of both techniques in patients with Benign prostatic obstruction (BPO)>80g. MATERIAL AND METHOD: Data from patients who underwent surgical treatment for BPO>80g from January 2010 to February 2015 at our institution were retrospectively collected and compared according to surgical technique...
January 9, 2018: Progrès en Urologie
Min Chul Cho, Won Hoon Song, Juhyun Park, Sung Yong Cho, Hyeon Jeong, Seung-June Oh, Jae-Seung Paick, Hwancheol Son
PURPOSE: To compare long-term outcomes for storage symptoms between PVP-120W-HPS and HoLEP, and to find factors influencing postoperative improvement of storage symptoms in the long term. MATERIALS AND METHODS: A total of 266 men (PVP-120W-HPS group, 165; HoLEP group, 101), for whom 60-month follow-up data were available, were included in our study. Outcomes were assessed serially at 6-, 12- 24-, 36-, 48-, and 60-months postoperatively, using the IPSS, uroflowmetry, and serum PSA level...
January 9, 2018: Journal of Urology
Liangbao Yang, Mei Mao, Binbin Zhou, Xianghu Tang, Cheng Chen, Meihong Ge, Pan Li, Xingjiu Huang, Jinhuai Liu
Construction of large area ordered anisotropic nanoparticles monolayer and acquisition of self-assembled interface film are still significant challenges. In this work, we have developed a rapid and valid method to fabricate large-scale close packed nanomaterials at the cyclohexane/water interface in which hydrophilic cetyltrimethylammonium bromide (CTAB) coated nanoparticles, Au nanorods (AuNRs), self-assembled into densely packed two dimensional (2D) arrays by regulating the surface ligand and suitable inducer...
January 11, 2018: Chemistry: a European Journal
P A Pacheco, L N C Rodrigues, J F S Ferreira, A C P Gomes, C J Veríssimo, H Louvandini, R L D Costa, L M Katiki
Albendazole (ABZ), a benzimidazole widely used to control gastrointestinal parasites, is poorly soluble in water, resulting in variable and incomplete bioavailability. This has favored the appearance ABZ-resistant nematodes and, consequently, an increase in its clinical ineffectiveness. Among the pharmaceutical techniques developed to increase drug efficacy, cyclodextrins (CDs) and other polymers have been extensively used with water-insoluble pharmaceutical drugs to increase their solubility and availability...
January 11, 2018: Parasitology Research
L Schiavo, S De Nicola, G Carotenuto
Pd(0) is able to catalyze oxygen-involving reactions because of its capability to convert molecular oxygen to the very reactive atomic form. Consequently, the embedding of a little amount of Pd(0) clusters in polymeric phases can be technologically exploited to enhance the incineration kinetic of these polymers. The effect of nanostructuration on the Pd(0) catalytic activity in the polymer incineration reaction has been studied using poly(N-vinyl-2-pyrrolidone) ([Formula: see text] = 10,000 gmol-1) as polymeric model system...
January 11, 2018: Nanoscale Research Letters
H P Zhao, P J Lü, L Y Zhang, W R Li, P Hou, J B Gao
Objective: To investigate the value of combined use of half-dose spectral CT based on the automatic spectral imaging mode selection (GSI Assist) and adaptive statistical iterative reconstruction (ASIR) in the CT examination of upper abdomen in obese patients as compared with conventional CT. Methods: Eight-two obese patients (body mass index≥29 kg/m(2)) were prospectively selected from October to December 2016, and contrast-enhanced CT during arterial phase (AP) and portal venous phase (PVP) were carried out in those patients...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Helena Líbalová, Pedro M Costa, Magnus Olsson, Lucian Farcal, Simona Ortelli, Magda Blosi, Jan Topinka, Anna L Costa, Bengt Fadeel
The rapid dissolution of copper oxide (CuO) nanoparticles (NPs) with release of ions is thought to be one of the main factors modulating their toxicity. Here we assessed the cytotoxicity of a panel of CuO NPs (12 nm ± 4 nm) with different surface modifications, i.e., anionic sodium citrate (CIT) and sodium ascorbate (ASC), neutral polyvinylpyrrolidone (PVP), and cationic polyethylenimine (PEI), versus the pristine (uncoated) NPs, using a murine macrophage cell line (RAW264.7). Cytotoxicity, reactive oxygen species (ROS) production, and cellular uptake were assessed...
December 29, 2017: Chemosphere
Bingjie Zhou, Bozhen Wu, Jine Wang, Qihong Qian, Jing Wang, Hongbin Xu, Sun Yang, Pan Feng, Wu Chen, Yulin Li, Jia Jiang, Baosan Han
In order to overcome the multidrug resistance (MDR) of tumor cells, it is very important to develop nanocarriers which can effectively load drugs while releasing them in a sequential way. Herein, nanohybrids with such properties have been fabricated by a first loading of one anticancer drug onto a silicate nanodisk (Laponite (LP), 25 nm in diameter and 0.92 nm in thickness) and a subsequent assembly with a pH sensitive poly(N-vinylpyrrolidone) (PVP) as a protective layer, followed by a loading of with another anticancer drug...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
S Roychoudhury, I Maldonado-Rosas, A Agarwal, S C Esteves, R Henkel, R Sharma
Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this study investigated sperm handling in a mouse ICSI model to (i) evaluate oocyte activation after injection of spermatozoa selected for rotational or linear motion in PVP; (ii) assess the effect of sperm selection in PVP, HA and medium on oocyte activation; (iii) examine the effects of PVP and HA on parthenogenetic oocyte activation and embryo development; and (iv) assess the oxidation-reduction potential (ORP) of spermatozoa exposed to PVP, HA or medium...
January 9, 2018: Andrologia
Silvina Orlandi, Josefina Priotti, Hermínio P Diogo, Dario Leonardi, Claudio J Salomon, Teresa G Nunes
Praziquantel (PZQ) is the recommended, effective, and safe treatment against all forms of schistosomiasis. Solid dispersions (SDs) in water-soluble polymers have been reported to increase solubility and bioavailability of poorly water-soluble drugs like PZQ, generally due to the amorphous form stabilization. In this work, poloxamer (PLX) 237 and poly(vinylpyrrolidone) (PVP) K30 were evaluated as potential carriers to revert PZQ crystallization. Binary and ternary SDs were prepared by the solvent evaporation method...
January 8, 2018: AAPS PharmSciTech
Zhao Guo, Wei Wang, Wen-Shan Gao, Fei Gao, Hui Wang, Wen-Yuan Ding
To compare the clinical outcomes and complications of high viscosity and low viscosity bone cement percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCF).From September 2009 to September 2015, 100 patients with OVCF were randomly divided into 2 groups: group H, using high viscosity cement (n = 50) or group L, using low viscosity cement (n = 50). The clinical outcomes were assessed by the visual analog scale (VAS), Oswestry Disability Index (ODI), kyphosis Cobb angle, vertebral height, and complications...
December 2017: Medicine (Baltimore)
Ming Guan, Zhen Zhang, Shilei Li, Jian'an Liu, Lu Liu, Hui Yang, Yangyang Zhang, Tie Wang, Zhenwen Zhao
Owing to the diversity of lipids, profiling and imaging multiple classes of lipids in one analysis by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is a great challenge. In this work, polyvinylpyrrolidone (PVP) capped silver nanoparticles (AgNPs) was used as the matrix for MALDI MSI for the first time to simultaneously analyze 10 classes of lipids from the brain. This analysis included fatty acids and their derivatives, sterols, CPAs, LPA and PAs, LPE and PEs, LPC and PCs, PS, Cers, SMs, and MAGs and DAGs, and other small metabolites...
March 1, 2018: Talanta
Shuangjiao Sun, Yanfen Wei, Hao Wang, Yupin Cao, Biyang Deng
A novel electrochemiluminescence (ECL) sensor with composite consisted of silica-sol, Zinc oxide nanoparticles (ZnO NPs), polyvinylpyrrolidone (PVP) and tris(2, 2'-bipyridine) ruthenium (II) was constructed. A new method for simultaneous determination of quinapril hydrochloride (QHCl) and its metabolite quinaprilat hydrochloride (QTHCl) in human plasma was developed using the ECL sensor coupled with capillary electrophoresis (CE). ECL intensities of QHCl and QTHCl increased dramatically when the ECL sensor was used as working electrode...
March 1, 2018: Talanta
Eirini Palazi, Evangelos Karavas, Panagiotis Barmpalexis, Margaritis Kostoglou, Stavroula Nanaki, Evi Christodoulou, Dimitrios N Bikiaris
The purpose of the present study was to use commercial available polymers like PVP/PEG, soluplus® and kollidon® SR to prepare immediate and sustained release formulations of felodipine by hot melt mixing method. Solid dispersions containing 5, 10, 20 and 30wt% drug have been prepared in a Haake-Buchler Reomixer at melt temperatures 130°C and mixing times 10min. As was found from DSC and XDR studies completely amorphous and miscible solid dispersions can be prepared. In all cases a single glass transition was recorded, which is depending from the used drug amount...
January 3, 2018: European Journal of Pharmaceutical Sciences
Eva Schepers, Griet Glorieux, Sunny Eloot, Michael Hulko, Adriana Boschetti-de-Fierro, Werner Beck, Bernd Krause, Wim Van Biesen
BACKGROUND: Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation products. In this paper, permeability for bacterial degradation products of membranes of comparable composition with different pore size was investigated with a new in vitro set-up that represents clinical flow and pressure conditions. METHODS: Dialysis was simulated with an AK200 machine using a low-flux, high-flux, medium cut-off (MCO) or high cut-off (HCO) device (n = 6/type)...
January 5, 2018: BMC Nephrology
Hans-Heinrich Limbach, Tal Pery, Niels Rothermel, Bruno Chaudret, Torsten Gutmann, Gerd Buntkowsky
The equilibration of H2, HD and D2 between the gas phase and surface hydrides of solid organic-ligand-stabilized Ru metal nanoparticles has been studied by gas phase 1H NMR spectroscopy using closed NMR tubes as batch reactors at room temperature and 800 mbar. When two different nanoparticle systems, Ru/PVP (PVP ≡ polyvinylpyrrolidone) and Ru/HDA (HDA ≡ hexadecylamine) were exposed to D2 gas, only the release of HD from the hydride containing surface could be detected in the initial stages of the reaction, but no H2...
January 5, 2018: Physical Chemistry Chemical Physics: PCCP
Zhenhua Dan, Jiafei Lu, Feng Li, Fengxiang Qin, Hui Chang
Two types of cupric oxide (Cu₂O) nanoarchitectures (nanobelts and nanopetal networks) have been achieved via immersion nanoporous copper (NPC) templates in anhydrous ethanol. NPC templates with different defect densities have been prepared by dealloying amorphous Ti60Cu40 ribbons in a mixture solution of hydrofluoric acid and polyvinylpyrrolidone (PVP) with different ratios of HF/PVP. Both a water molecule reactant acting as OH- reservoir and the ethanol molecule serving as stabilizing or capping reagent for inhibiting the random growth of Cu₂Oplayed a role of the formation of 2-dimensional Cu₂O nanoarchitectures...
December 31, 2017: Nanomaterials
Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Zhen Guo, Haibao Wang, Qianwang Chen
Phothermal therapy has received increasing attention in recent years as a potentially effective way for treatment of cancer. In pursuit of a more biocompatible photothermal agent, we utilize bio-safe materials-ellagic acid (EA), polyvinyl pyrrolidone (PVP) and iron element as the building blocks, and successfully fabricate homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nano-agent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo...
January 4, 2018: ACS Applied Materials & Interfaces
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