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https://www.readbyqxmd.com/read/28088652/convergence-of-interoception-emotion-and-social-cognition-a-twofold-fmri-meta-analysis-and-lesion-approach
#1
Federico Adolfi, Blas Couto, Fabian Richter, Jean Decety, Jessica Lopez, Mariano Sigman, Facundo Manes, Agustín Ibáñez
Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28088156/path-integral-approach-to-the-wigner-representation-of-canonical-density-operators-for-discrete-systems-coupled-to-harmonic-baths
#2
Andrés Montoya-Castillo, David R Reichman
We derive a semi-analytical form for the Wigner transform for the canonical density operator of a discrete system coupled to a harmonic bath based on the path integral expansion of the Boltzmann factor. The introduction of this simple and controllable approach allows for the exact rendering of the canonical distribution and permits systematic convergence of static properties with respect to the number of path integral steps. In addition, the expressions derived here provide an exact and facile interface with quasi- and semi-classical dynamical methods, which enables the direct calculation of equilibrium time correlation functions within a wide array of approaches...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088139/long-range-interactions-from-the-many-pair-expansion-a-different-avenue-to-dispersion-in-dft
#3
Piotr de Silva, Tianyu Zhu, Troy Van Voorhis
One of the several problems that plague majority of density functional theory calculations is their inability to properly account for long-range correlations giving rise to dispersion forces. The recently proposed many-pair expansion (MPE) [T. Zhu et al., Phys. Rev. B 93, 201108(R) (2016)] is a hierarchy of approximations that systematically corrects any deficiencies of an approximate functional to finally converge to the exact energy. This is achieved by decomposing the total density into a sum of two-electron densities and accounting for successive two-, four-, six-,… electron interactions...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28087807/field-validation-of-the-los-angeles-motor-scale-as-a-tool-for-paramedic-assessment-of-stroke-severity
#4
Joon-Tae Kim, Pil-Wook Chung, Sidney Starkman, Nerses Sanossian, Samuel J Stratton, Marc Eckstein, Frank D Pratt, Robin Conwit, David S Liebeskind, Latisha Sharma, Lucas Restrepo, May-Kim Tenser, Miguel Valdes-Sueiras, Jeffrey Gornbein, Scott Hamilton, Jeffrey L Saver
BACKGROUND AND PURPOSE: The Los Angeles Motor Scale (LAMS) is a 3-item, 0- to 10-point motor stroke-deficit scale developed for prehospital use. We assessed the convergent, divergent, and predictive validity of the LAMS when performed by paramedics in the field at multiple sites in a large and diverse geographic region. METHODS: We analyzed early assessment and outcome data prospectively gathered in the FAST-MAG trial (Field Administration of Stroke Therapy-Magnesium phase 3) among patients with acute cerebrovascular disease (cerebral ischemia and intracranial hemorrhage) within 2 hours of onset, transported by 315 ambulances to 60 receiving hospitals...
January 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28087796/prior-military-service-identity-stigma-and-mental-health-among-transgender-older-adults
#5
Charles P Hoy-Ellis, Chengshi Shiu, Kathleen M Sullivan, Hyun-Jun Kim, Allison M Sturges, Karen I Fredriksen-Goldsen
PURPOSE OF THE STUDY: Converging evidence from large community-based samples, Internet studies, and Veterans Health Administration data suggest that transgender adults have high rates of U.S. military service. However, little is known about the role of prior military service in their mental health later in life, particularly in relation to identity stigma. In this article, we examine relationships between prior military service, identity stigma, and mental health among transgender older adults...
February 2017: Gerontologist
https://www.readbyqxmd.com/read/28087771/genome-wide-convergence-during-evolution-of-mangroves-from-woody-plants
#6
Shaohua Xu, Ziwen He, Zixiao Guo, Zhang Zhang, Gerald J Wyckoff, Anthony Greenberg, Chung-I Wu, Suhua Shi
When living organisms independently invade a new environment, the evolution of similar phenotypic traits is often observed. An interesting but contentious issue is whether the underlying molecular biology also converges in the new habitat. Independent invasions of tropical intertidal zones by woody plants, collectively referred to as mangrove trees, represent some dramatic examples. The high salinity, hypoxia and other stressors in the new habitat might have affected both genomic features and protein structures...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28087713/functional-genomics-reveals-that-tumors-with-activating-phosphoinositide-3-kinase-mutations-are-dependent-on-accelerated-protein-turnover
#7
Teresa Davoli, Kristen E Mengwasser, Jingjing Duan, Ting Chen, Camilla Christensen, Eric C Wooten, Anthony N Anselmo, Mamie Z Li, Kwok-Kin Wong, Kristopher T Kahle, Stephen J Elledge
Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are frequently identified in cancer. To identify pathways that support PI3K oncogenesis, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type or mutant PIK3CA to search for PI3K synthetic-lethal (SL) genes. A combined analysis of these results with a meta-analysis of two other large-scale RNAi screening data sets in PI3K mutant cancer cell lines converged on ribosomal protein translation and proteasomal protein degradation as critical nononcogene dependencies for PI3K-driven tumors...
December 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/28087661/disturbance-by-an-endemic-rodent-in-an-arid-shrubland-is-a-habitat-filter-effects-on-plant-invasion-and-taxonomical-functional-and-phylogenetic-community-structure
#8
Víctor M Escobedo, Rodrigo S Rios, Cristian Salgado-Luarte, Gisela C Stotz, Ernesto Gianoli
BACKGROUND AND AIMS: Disturbance often drives plant invasion and may modify community assembly. However, little is known about how these modifications of community patterns occur in terms of taxonomic, functional and phylogenetic structure. This study evaluated in an arid shrubland the influence of disturbance by an endemic rodent on community functional divergence and phylogenetic structure as well as on plant invasion. It was expected that disturbance would operate as a habitat filter favouring exotic species with short life cycles...
January 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28087445/distinct-subcomponents-of-mouse-retinal-ganglion-cell-receptive-fields-are-differentially-altered-by-light-adaptation
#9
C S Cowan, J Sabharwal, R L Seilheimer, S M Wu
The remarkable dynamic range of vision is facilitated by adaptation of retinal sensitivity to ambient lighting conditions. An important mechanism of sensitivity adaptation is control of the spatial and temporal window over which light is integrated. The retina accomplishes this by switching between parallel synaptic pathways with differing kinetics and degrees of synaptic convergence. However, the relative shifts in spatial and temporal integration are not well understood - particularly in the context of the antagonistic spatial surround...
January 10, 2017: Vision Research
https://www.readbyqxmd.com/read/28087270/examining-the-reliability-and-validity-of-the-clinical-assessment-interview-for-negative-symptoms-within-the-management-of-schizophrenia-in-clinical-practice-mosaic-multisite-national-study
#10
Jack J Blanchard, Kristen R Bradshaw, Cristina P Garcia, Henry A Nasrallah, Philip D Harvey, Daniel Casey, Csilla T Csoboth, James I Hudson, Laura Julian, Ellen Lentz, Keith H Nuechterlein, Diana O Perkins, Tracey G Skale, Lonnie R Snowden, Rajiv Tandon, Cenk Tek, Dawn Velligan, Sophia Vinogradov, Cedric O'Gorman
The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28087058/robust-observer-based-passive-control-for-uncertain-singular-time-delay-systems-subject-to-actuator-saturation
#11
Yuechao Ma, Pingjing Yang, Yifang Yan, Qingling Zhang
This paper investigates the problem of robust observer-based passive control for uncertain singular time-delay system subject to actuator saturation. A polytopic approach is used to describe the saturation behavior. First, by constructing Lyapunov-Krasovskii functional, a less conservative sufficient condition is obtained which guarantees that the closed-loop system is regular, impulse free, stable and robust strictly passive. Then, with this condition, the design method of state feedback controller and the observer are given by solving linear matrix inequalities...
January 10, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28086828/subjective-and-objective-assessment-of-physical-activity-in-multiple-sclerosis-and-their-relation-to-health-related-quality-of-life
#12
Theresa Krüger, Janina R Behrens, Anuschka Grobelny, Karen Otte, Sebastian Mansow-Model, Bastian Kayser, Judith Bellmann-Strobl, Alexander U Brandt, Friedemann Paul, Tanja Schmitz-Hübsch
BACKGROUND: Physical activity (PA) is frequently restricted in people with multiple sclerosis (PwMS) and aiming to enhance PA is considered beneficial in this population. We here aimed to explore two standard methods (subjective plus objective) to assess PA reduction in PwMS and to describe the relation of PA to health-related quality of life (hrQoL). METHODS: PA was objectively measured over a 7-day period in 26 PwMS (EDSS 1.5-6.0) and 30 matched healthy controls (HC) using SenseWear mini® armband (SWAmini) and reported as step count, mean total and activity related energy expenditure (EE) as well as time spent in PA of different intensities...
January 13, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28081434/implicit-attitudes-towards-risky-driving-development-and-validation-of-an-affect-misattribution-procedure-for-speeding
#13
Andrei Rusu, Paul Sârbescu, Daniela Moza, Alexandra Stancu
The present study aimed to develop and validate an instrument for measuring implicit attitudes towards speeding, based on the Affect Misattribution Procedure (AMP). The data collected from 140 drivers supported the reliability of the AMP (α=0.80). Results provided some support for the construct validity of the AMP, through its convergence with explicit attitudes towards speeding (r=0.22). Also, the AMP incrementally predicted driving violations (ΔR(2)=0.034) and traffic accidents (ΔR(2)=0.022), above and beyond demographic variables and explicit attitudes towards speeding, thus providing initial evidence for its criterion validity...
January 9, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28080960/myogenic-regulatory-transcription-factors-regulate-growth-in-rhabdomyosarcoma
#14
Inês M Tenente, Madeline N Hayes, Myron S Ignatius, Karin McCarthy, Marielle Yohe, Sivasish Sindiri, Berkley Gryder, Mariana L Oliveira, Ashwin Ramakrishnan, Qin Tang, Eleanor Y Chen, G Petur Nielsen, Javed Khan, David M Langenau
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growth. Here, we used a transgenic zebrafish model to show that Myf5 is sufficient to confer tumor-propagating potential to RMS cells and caused tumors to initiate earlier and have higher penetrance...
January 12, 2017: ELife
https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#15
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28080262/processing-speed-test-validation-of-a-self-administered-ipad-%C3%A2-based-tool-for-screening-cognitive-dysfunction-in-a-clinic-setting
#16
Stephen M Rao, Genna Losinski, Lyla Mourany, David Schindler, Bernadett Mamone, Christine Reece, Danielle Kemeny, Sridar Narayanan, Deborah M Miller, Francois Bethoux, Robert A Bermel, Richard Rudick, Jay Alberts
BACKGROUND: Cognitive dysfunction is common in multiple sclerosis (MS) patients and has important consequences for daily activities, yet, unlike motor function, is not routinely assessed in the clinic setting. We developed the Processing Speed Test (PST), a self-administered iPad(®)-based tool to measure MS-related deficits in processing speed. OBJECTIVE: To determine whether the PST is valid for screening cognitive dysfunction by comparing it to the paper-and-pencil Symbol Digit Modalities Test (SDMT)...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080121/hand-matters-left-hand-gestures-enhance-metaphor-explanation
#17
Paraskevi Argyriou, Christine Mohr, Sotaro Kita
Research suggests that speech-accompanying gestures influence cognitive processes, but it is not clear whether the gestural benefit is specific to the gesturing hand. Two experiments tested the "(right/left) hand-specificity" hypothesis for self-oriented functions of gestures: gestures with a particular hand enhance cognitive processes involving the hemisphere contralateral to the gesturing hand. Specifically, we tested whether left-hand gestures enhance metaphor explanation, which involves right-hemispheric processing...
January 12, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28080108/the-brief-problem-monitor-parent-form-bpm-p-a-short-version-of-the-child-behavior-checklist-psychometric-properties-in-spanish-6-to-8-year-old-children
#18
Eva Penelo, Núria de la Osa, José Blas Navarro, Josep Maria Domènech, Lourdes Ezpeleta
We provide the first validation data on the Spanish version of the Brief Problem Monitor-Parent form (BPM-P), a recently developed abbreviated version of the 120-item Child Behavior Checklist for Ages 6 to 18 (CBCL/6-18) in young schoolchildren. Parents of a community sample of 521 children aged 6-8 answered the CBCL/6-18 yearly, and the 19 BPM-P items were examined; parents also provided different measures of psychopathology. Confirmatory factor analysis of the expected 3-factor model (attention, externalizing, and internalizing) showed adequate fit (root mean square error of approximation, RMSEA ≤ ...
January 12, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28080104/measuring-black-men-s-police-based-discrimination-experiences-development-and-validation-of-the-police-and-law-enforcement-ple-scale
#19
Devin English, Lisa Bowleg, Ana Maria Del Río-González, Jeanne M Tschann, Robert P Agans, David J Malebranche
OBJECTIVES: Although social science research has examined police and law enforcement-perpetrated discrimination against Black men using policing statistics and implicit bias studies, there is little quantitative evidence detailing this phenomenon from the perspective of Black men. Consequently, there is a dearth of research detailing how Black men's perspectives on police and law enforcement-related stress predict negative physiological and psychological health outcomes. This study addresses these gaps with the qualitative development and quantitative test of the Police and Law Enforcement (PLE) Scale...
January 12, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28080093/psychometric-properties-of-the-short-inventory-of-problems-sip-with-adjudicated-dui-intervention-participants
#20
David T Morse, Angela A Robertson
We used responses of two large samples of court-ordered participants from a statewide alcohol/driving safety program to investigate factor structure, score reliability, and criterion-related validity of the Short Inventory of Problems (SIP). Exploratory and confirmatory factor analyses, using both item-level and subscore-level data, support a one-factor structure for the SIP. Internal consistency score reliability estimates were consistent across samples and high enough to warrant use for making decisions about individuals...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
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