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https://www.readbyqxmd.com/read/27922105/interplay-of-coupling-and-common-noise-at-the-transition-to-synchrony-in-oscillator-populations
#1
Anastasiya V Pimenova, Denis S Goldobin, Michael Rosenblum, Arkady Pikovsky
There are two ways to synchronize oscillators: by coupling and by common forcing, which can be pure noise. By virtue of the Ott-Antonsen ansatz for sine-coupled phase oscillators, we obtain analytically tractable equations for the case where both coupling and common noise are present. While noise always tends to synchronize the phase oscillators, the repulsive coupling can act against synchrony, and we focus on this nontrivial situation. For identical oscillators, the fully synchronous state remains stable for small repulsive coupling; moreover it is an absorbing state which always wins over the asynchronous regime...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921264/validation-of-the-tampa-scale-for-kinesiophobia-for-temporomandibular-disorders-tsk-tmd-in-patients-with-painful-tmd
#2
Songlin He, Jinhua Wang, Ping Ji
BACKGROUND: The aim of the study was to validation of the Tampa Scale for Kinesiophobia for Temporomandibular Disorders (TSK-TMD) for use in patients with painful TMD. METHODS: The original TSK-TMD was translated and cross-culturally adaptated following international guidelines. A total of 160 patients with temporomandibular disorders (TMD) were enrolled to fill out the scale. The internal consistency and test-retest methods were used to evaluate the reliability of the TSK-TMD...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27921223/psychometric-properties-of-the-chinese-version-of-the-reproductive-concerns-after-cancer-scale-rcac-for-young-female-cancer-survivors
#3
Ting-Ting Qiao, Wei Zheng, Wei Xing, Li-Xia Zhang, Wei Zhang, Yan-Ping Shi, Xiao-Juan Chen
PURPOSE: This study aimed to translate, culturally adapt, and test the psychometric properties of the Reproductive Concerns After Cancer scale (RCAC) in young Chinese female cancer survivors. METHODS: The Chinese version of the RCAC was developed using the standard Functional Assessment of Chronic Illness Therapy (FACIT) translation methodology, and then 800 young Chinese female cancer survivors were recruited to complete the scale. The validation of the RCAC is as follows: (1) content validity was evaluated by a group of experts; (2) factor structure was assessed using confirmatory factor analysis and factorial invariance analysis; (3) convergent validity was determined by correlations with the Patient Health Questionnaire 9 (PHQ-9) and Functional Assessment of Cancer Therapy-General (FACT-G) scale; (4) internal consistency reliability was assessed using Cronbach's α coefficient; and (5) test-retest reliability was assessed using intra-class correlations...
December 5, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27921073/evaluation-of-lesion-detectability-in-positron-emission-tomography-when-using-a-convergent-penalized-likelihood-image-reconstruction-method
#4
Kristen A Wangerin, Sangtae Ahn, Scott Wollenweber, Steven G Ross, Paul E Kinahan, Ravindra M Manjeshwar
We have previously developed a convergent penalized likelihood (PL) image reconstruction algorithm using the relative difference prior (RDP) and showed that it achieves more accurate lesion quantitation compared to ordered subsets expectation maximization (OSEM). We evaluated the detectability of low-contrast liver and lung lesions using the PL-RDP algorithm compared to OSEM. We performed a two-alternative forced choice study using a channelized Hotelling observer model that was previously validated against human observers...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27921034/crowdsourcing-precision-cerebrovascular-health-imaging-and-cloud-seeding-a-million-brains-initiative%C3%A2
#5
David S Liebeskind
Crowdsourcing, an unorthodox approach in medicine, creates an unusual paradigm to study precision cerebrovascular health, eliminating the relative isolation and non-standardized nature of current imaging data infrastructure, while shifting emphasis to the astounding capacity of big data in the cloud. This perspective envisions the use of imaging data of the brain and vessels to orient and seed A Million Brains Initiative™ that may leapfrog incremental advances in stroke and rapidly provide useful data to the sizable population around the globe prone to the devastating effects of stroke and vascular substrates of dementia...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27920617/chiropractic-identity-a-neurological-professional-and-political-assessment
#6
REVIEW
Anthony L Rosner
OBJECTIVE: The purpose of this article is to propose a focused assessment of the identity of chiropractic and its profession, triangulating multiple viewpoints converging upon various aspects and definitions of neurology, manual medicine, and alternative or mainstream medicine. DISCUSSION: Over 120 years since its inception, chiropractic has struggled to achieve an identity for which its foundations could provide optimal health care. Despite recognition of the benefits of spinal manipulation in various government guidelines, advances in US military and Veterans Administration, and persistently high levels of patient satisfaction, the chiropractic profession remains underrepresented in most discussions of health care delivery...
December 2016: Journal of Chiropractic Humanities
https://www.readbyqxmd.com/read/27920368/use-of-the-concordance-index-for-predictors-of-censored-survival-data
#7
Adam R Brentnall, Jack Cuzick
The concordance index is often used to measure how well a biomarker predicts the time to an event. Estimators of the concordance index for predictors of right-censored data are reviewed, including those based on censored pairs, inverse probability weighting and a proportional-hazards model. Predictive and prognostic biomarkers often lose strength with time, and in this case the aforementioned statistics depend on the length of follow up. A semi-parametric estimator of the concordance index is developed that accommodates converging hazards through a single parameter in a Pareto model...
December 5, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27920282/nmda-receptor-encephalitis-and-other-antibody-mediated-disorders-of-the-synapse-the-2016-cotzias-lecture
#8
Josep Dalmau
Investigations during the last 10 years have revealed a group of disorders mediated by antibodies against ion channels and synaptic receptors, which cause both neurologic and psychiatric symptoms. In this review, I discuss the process of discovery and immunologic triggers of these disorders, and use anti-NMDA receptor encephalitis to emphasize the importance of understanding the underlying physiopathologic mechanisms in those diseases. A better knowledge of these mechanisms reveals points of convergence with other disorders (e...
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27920117/reliability-and-validity-of-the-dutch-version-of-the-consultation-and-relational-empathy-measure-in-primary-care
#9
Inge van Dijk, Nick Scholten Meilink Lenferink, Peter L B J Lucassen, Stewart W Mercer, Chris van Weel, Tim C Olde Hartman, Anne E M Speckens
BACKGROUND: Empathy is an essential skill in doctor-patient communication with positive effects on compliance, patient satisfaction and symptom duration. There are no validated patient-rated empathy measures available in Dutch. OBJECTIVE: To investigate the validity and reliability of a Dutch version of the Consultation and Relational Empathy (CARE) Measure, a widely used 10-item patient-rated questionnaire of physician empathy. METHODS: After translation and back translation, the Dutch CARE Measure was distributed among patients from 19 general practitioners in 5 primary care centers...
December 5, 2016: Family Practice
https://www.readbyqxmd.com/read/27920026/the-transcellular-propagation-and-intracellular-trafficking-of-%C3%AE-synuclein
#10
George K Tofaris, Michel Goedert, Maria Grazia Spillantini
Parkinson's disease is the second most common neurodegenerative disorder, with only partial symptomatic therapy and no mechanism-based therapies. The accumulation and aggregation of α-synuclein is causatively linked to the sporadic form of the disease, which accounts for 95% of cases. The pathology is a result of a gain of toxic function of misfolded α-synuclein conformers, which can template the aggregation of soluble monomers and lead to cellular dysfunction, at least partly by interfering with membrane fusion events at synaptic terminals...
December 5, 2016: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/27919864/taxonomy-for-the-rehabilitation-of-knee-conditions-trak-a-digital-intervention-to-support-the-self-care-components-of-anterior-cruciate-ligament-rehabilitation-protocol-of-a-feasibility-study
#11
Emma Dunphy, Fiona L Hamilton, Kate Button
BACKGROUND: Rupture of the anterior cruciate ligament (ACL) is common, especially in the active population. In defining the problem of ACL rehabilitation, this study draws from the knowledge that improved self-care, strength, and fitness are associated with better outcomes. Traditional rehabilitation involves regular physiotherapy, but it is not clear what the optimal way for delivering rehabilitation is, and it varies widely across the world. Evidence for treatments are discussed in the literature, however standard length of rehabilitation and frequency of appointments are unknown...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27919678/individual-differences-in-high-level-biological-motion-tasks-correlate-with-autistic-traits
#12
Jeroen J A van Boxtel, Yujia Peng, Junzhu Su, Hongjing Lu
Human actions are rich in social cues and play an essential role in interacting with the social environment. Hence, the perception of biological motion (i.e., movement elicited by humans and other animals) is considered to be an important gauge of a person's social cognition capacities. It has been well-documented that Autism Spectrum Disorder (ASD) is associated with difficulties in social interactions. In the present study, we examined whether individual differences in biological motion perception relate to the degree of autistic traits among people in the typically-developing population...
December 2, 2016: Vision Research
https://www.readbyqxmd.com/read/27919435/social-return-on-investment-development-and-convergence
#13
Jeremy Nicholls
Social return on investment (SROI) is a relatively new approach to assessing the value created by human activity. This paper explores the development of SROI since its creation in 1996 and concludes by outlining areas for future development. SROI is compared with mainstream global approaches to generating standardized information that informs resource allocation decisions, financial accounting in general, sustainability accounting in the private sector and cost benefit analysis in the public sector.
November 21, 2016: Evaluation and Program Planning
https://www.readbyqxmd.com/read/27919067/genome-wide-changes-in-lncrna-splicing-and-regional-gene-expression-patterns-in-autism
#14
Neelroop N Parikshak, Vivek Swarup, T Grant Belgard, Manuel Irimia, Gokul Ramaswami, Michael J Gandal, Christopher Hartl, Virpi Leppa, Luis de la Torre Ubieta, Jerry Huang, Jennifer K Lowe, Benjamin J Blencowe, Steve Horvath, Daniel H Geschwind
Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood. Here, through post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, to our knowledge, we interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden our understanding of molecular convergence in ASD. Our analysis reveals ASD-associated dysregulation of primate-specific long noncoding RNAs (lncRNAs), downregulation of the alternative splicing of activity-dependent neuron-specific exons, and attenuation of normal differences in gene expression between the frontal and temporal lobes...
December 5, 2016: Nature
https://www.readbyqxmd.com/read/27918948/adult-autism-subthreshold-spectrum-adas-spectrum-validation-of-a-questionnaire-investigating-subthreshold-autism-spectrum
#15
L Dell'Osso, C Gesi, E Massimetti, I M Cremone, M Barbuti, G Maccariello, I Moroni, S Barlati, G Castellini, M Luciano, L Bossini, M Rocchetti, M Signorelli, E Aguglia, A Fagiolini, P Politi, V Ricca, A Vita, C Carmassi, M Maj
AIM: Increasing literature has shown the usefulness of a dimensional approach to autism. The present study aimed to determine the psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum), a new questionnaire specifically tailored to assess subthreshold forms of autism spectrum disorder (ASD) in adulthood. METHODS: 102 adults endorsing at least one DSM-5 symptom criterion for ASD (ASDc), 143 adults diagnosed with a feeding and eating disorder (FED), and 160 subjects with no mental disorders (CTL), were recruited from 7 Italian University Departments of Psychiatry and administered the following: SCID-5, Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale 14-item version (RAADS-14), and AdAS Spectrum...
November 9, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27918699/validation-of-questionnaire-assessed-physical-activity-in-comparison-with-objective-measures-using-accelerometers-and-physical-performance-measures-among-community-dwelling-adults-aged-%C3%A2-85-years-in-tokyo-japan
#16
Yuko Oguma, Yusuke Osawa, Michiyo Takayama, Yukiko Abe, Shigeho Tanaka, I-Min Lee, Yasumichi Arai
BACKGROUND: To date, there is no physical activity (PA) questionnaire with convergent and construct validity for the oldest-old. The aim of the present study was to investigate the validity of questionnaire-assessed PA in comparison with objective measures determined by uniaxial and triaxial accelerometers and physical performance measures in the oldest-old. METHODS: Participants were 155 elderly (mean age 90 years) who were examined at the university and agreed to wear an accelerometer for 7 days in the 3-year-follow-up survey of the Tokyo Oldest-Old Survey of Total Health...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27918636/4d-printing-of-shape-memory-based-personalized-endoluminal-medical-devices
#17
Matt Zarek, Nicola Mansour, Shir Shapira, Daniel Cohn
The convergence of additive manufacturing and shape-morphing materials is promising for the advancement of personalized medical devices. The capability to transform 3D objects from one shape to another, right off the print bed, is known as 4D printing. Shape memory thermosets can be tailored to have a range of thermomechanical properties favorable to medical devices, but processing them is a challenge because they are insoluble and do not flow at any temperature. This study presents here a strategy to capitalize on a series of medical imaging modalities to construct a printable shape memory endoluminal device, exemplified by a tracheal stent...
December 5, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27918617/thermodynamic-insights-on-a-bistable-acid-base-switchable-molecular-shuttle-with-strongly-shifted-co-conformational-equilibria
#18
Giulio Ragazzon, Alberto Credi, Benoit Colasson
Bistable [2]rotaxanes in which the affinities of the two stations can be reversed form the basis of molecular shuttles. Gaining quantitative information on such rotaxanes in which the ring distribution between the two stations is largely nonsymmetric has proven to be very challenging. Here we report on two independent experimental methodologies - based on luminescence lifetime measurement and acid-base titrations - to determine the relative populations of the two co-conformations of a [2]rotaxane. The assays yield convergent results and are sensitive enough to measure an equilibrium constant (K ~ 4000) out of reach for NMR spectroscopy...
December 5, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27918187/enhancing-relationship-quality-measurement-the-development-of-the-relationship-flourishing-scale
#19
Blaine J Fowers, Jean-Philippe Laurenceau, Randall D Penfield, Laura M Cohen, Samantha F Lang, Meghan B Owenz, Elizabeth Pasipandoya
Relationship quality is the most frequently assessed construct in the intimate relationships literature. Dozens of assessment instruments exist, but the vast majority conceptualize relationship quality in terms of satisfaction (or a similar construct), which focuses on the hedonic (pleasure or happiness) dimension of the relationship. Some scholars question whether the richness and depth of adult intimate relationships can be captured by satisfaction ratings and suggest focusing on a complementary eudaimonic (human flourishing) dimension of the relationship...
December 2016: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/27918186/prison-break-karl-menninger-s-the-crime-of-punishment-and-its-reception-in-u-s-psychology
#20
David C Devonis, Jessica Triggs
In 1968, Karl Menninger, a highly visible and vocal U.S. psychiatrist, published a call to action on prison reform, The Crime of Punishment (Menninger, 1966/1968). This widely circulated book's central idea is that punishment as practiced in penal settings is an injustice amounting to a crime. At the outset, The Crime of Punishment quickly achieved national attention. Within mainstream psychology, its antipunishment message encountered a changed climate in which punishment, thought ineffective during the period 1930 through 1960, was redefined as an effective component in learning...
December 5, 2016: History of Psychology
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