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https://www.readbyqxmd.com/read/28893616/does-antero-lateral-ankle-impingement-exist
#1
REVIEW
F Molinier, J Benoist, F Colin, J Padiolleau, S Guillo, J Stone, T Bauer
Antero-lateral ankle impingement syndrome (ALAIS) is a well-established clinical entity that is a common consequence of ankle sprains. Injury to the anterior talo-fibular ligament plays a key role in the genesis of ALAIS. Arthroscopic antero-lateral synovectomy is the standard of care. However, this treatment approach may deserve to be challenged, as it does not include any procedure on the ligaments, despite the presence in some patients of lateral rotational micro-instability of the ankle, without objective laxity...
September 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28883689/lateral-column-lengthening-for-adolescent-idiopathic-pes-planovalgus-deformity-systematic-review
#2
REVIEW
Sanjay Kumar, S V Sonanis
Pes planovalgus is the commonest foot deformity in children and presents with wide range of severity and symptoms. Surgery is mostly indicated for significant malalignment, resistant to non-surgical management. Lateral column lengthening is considered an appealing option as does not involve arthrodesis and allows for further growth and foot development. METHODS: We conducted a systematic review on lateral column lengthening for pes planovalgus deformity in line with PRISMA-P Checklist...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28883012/fibular-insufficiency-fracture-an-under-reported-complication-of-advanced-tibialis-posterior-dysfunction
#3
Suresh Srinivasan, Harish Kurup
We present a case of fibular insufficiency (stress) fracture in a patient with pre-existing asymptomatic advanced tibialis posterior dysfunction. The patient had severe planovalgus (flat foot) deformity but no pain before the injury; hence had never sought any treatment. She was first treated conservatively for the fracture which failed to control the deformity and had ongoing symptoms. She eventually required tibio-talo-calcaneal fusion. To the best of our knowledge, this is the first case report of this condition in the English literature...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28877167/measuring-dispositional-flow-validity-and-reliability-of-the-dispositional-flow-state-scale-2-italian-version
#4
Eleonora F M Riva, Giuseppe Riva, Cosimo Talò, Marco Boffi, Nicola Rainisio, Linda Pola, Barbara Diana, Daniela Villani, Luca Argenton, Paolo Inghilleri
OBJECTIVE: The aim of this study is to evaluate the psychometric properties of the Italian version of the Dispositional Flow Scale-2 (DFS-2), for use with Italian adults, young adults and adolescents. METHOD: In accordance with the guidelines for test adaptation, the scale has been translated with the method of back translation. The understanding of the item has been checked according to the latest standards on the culturally sensitive translation. The scale thus produced was administered to 843 individuals (of which 60...
2017: PloS One
https://www.readbyqxmd.com/read/28875416/nmr-study-of-non-structural-proteins-part-iii-1-h-13-c-15-n-backbone-and-side-chain-resonance-assignment-of-macro-domain-from-chikungunya-virus-chikv
#5
Michail V Lykouras, Aikaterini C Tsika, Julie Lichière, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A Spyroulias
Macro domains are conserved protein domains found in eukaryotic organisms, bacteria, and archaea as well as in certain viruses. They consist of 130-190 amino acids and can bind ADP-ribose. Although the exact role of these domains is not fully understood, the conserved binding affinity for ADP-ribose indicates that this ligand is important for the function of the domain. Such a macro domain is also present in the non-structural protein 3 (nsP3) of Chikungunya Alphavirus (CHIKV) and consists of 160 amino acids...
September 5, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28866776/-1-h-15-n-13-c-backbone-resonance-assignments-of-human-phosphoglycerate-kinase-in-a-transition-state-analogue-complex-with-adp-3-phosphoglycerate-and-magnesium-trifluoride
#6
Zhalgas Serimbetov, Nicola J Baxter, Matthew J Cliff, Jonathan P Waltho
Human phosphoglycerate kinase (PGK) is an energy generating glycolytic enzyme that catalyses the transfer of a phosphoryl group from 1,3-bisphosphoglycerate (BPG) to ADP producing 3-phosphoglycerate (3PG) and ATP. PGK is composed of two α/β Rossmann-fold domains linked by a central α-helix and the active site is located in the cleft formed between the N-domain which binds BPG or 3PG, and the C-domain which binds the nucleotides ADP or ATP. Domain closure is required to bring the two substrates into close proximity for phosphoryl transfer to occur, however previous structural studies involving a range of native substrates and substrate analogues only yielded open or partly closed PGK complexes...
September 2, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28826290/associations-of-alveolar-bone-loss-and-interleukin-1%C3%AE-levels-in-one-and-two-stage-surgical-procedures-a-randomized-prospective-trial
#7
Tuba Talo Yildirim, Filiz Acun Kaya, Beran Yokus, Mehmet Colak, Eylem Ozdemir Kaya, Giray Tekin, Ebru Saribas, Ersin Uysal, Guliz N Guncu
OBJECTIVE: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1β levels in one- and two-stage surgical procedures. MATERIALS AND METHODS: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II)...
August 21, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28815423/backbone-and-side-chain-1-h-15-n-and-13-c-resonance-assignments-of-a-novel-staphylococcal-inhibitor-of-myeloperoxidase
#8
Nicoleta T Ploscariu, Alvaro I Herrera, Srinivas Jayanthi, Thallapuranam K Suresh Kumar, Brian V Geisbrecht, Om Prakash
The bacterium Staphylococcus aureus produces an array of anti-inflammatory molecules that prevent the innate immune system from recognizing it as a pathogen and clearing it from the host. In the acute phase of inflammation, our immune system relies on neutrophils to clear invading bacteria. Recently, novel classes of secreted proteins from S. aureus, including the Extracellular Adherence Protein (EAP) family (Stapels et al., Proc Natl Acad Sci USA 111:13187-13192, 2014) and the Staphylococcal Peroxidase Inhibitor (SPIN), (unpublished work) have been identified as highly selective inhibitors acting on Neutrophil Serine Proteases (NSPs) and myeloperoxidase (MPO) respectively...
August 16, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28808891/nmr-backbone-resonance-assignment-of-new-delhi-metallo-beta-lactamase
#9
Chendie Yao, Qiong Wu, Guohua Xu, Conggang Li
The emerging of the New Delhi metallo-beta-lactamase (NDM-1) has become one of the greatest threats to the clinical treatment. Although the structure of NDM-1 has been determined by X-ray crystallography, the molecular mechanism and process of catalysis reaction remain elusive. NMR spectroscopy plays a unique role in the characterization of conformational dynamics. Here we report the backbone (1)H, (15)N and (13)C chemical shift assignments of NDM-1 by heteronuclear multidimensional NMR spectroscopy as well as its secondary structure in solution as predicted by TALOS+...
August 14, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28698915/surgical-treatment-of-stage-ii-posterior-tibialis-tendon-dysfunction-ten-year-clinical-and-radiographic-results
#10
Alberto Ruffilli, Francesco Traina, Sandro Giannini, Roberto Buda, Fabrizio Perna, Cesare Faldini
INTRODUCTION: Grade II chronic tibialis posterior tendon dysfunction (PTTD) poses a reconstructive challenge to the orthopaedic surgeon. Aim of this retrospective study is to report the clinical and radiographical results of a case series of 63 patients (102 ft) affected by grade II PTTD who underwent tailored surgical treatment at 10-year mean follow-up. MATERIALS AND METHODS: Sixty-three patients (102 ft) were available for clinical and radiological evaluation and were retrospectively reviewed at a mean follow-up of 125...
July 11, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28670651/synthesis-and-biological-evaluation-of-n-arylated-lactam-type-iminosugars-as-potential-immunosuppressive-agents
#11
Hai-Qian Liu, Cheng-Cheng Song, You-Hong Niu, Tao Li, Qin Li, Xin-Shan Ye
Since the immunosuppressive agents currently used in clinics have significant side effects, it is very important to search for new effective and safe immunosuppressants. Iminosugars as a new class of immunosuppressants are less explored. In this report, 24 new N-arylated iminosugar derivatives, including d-talo and d-galacto epimers, were designed and synthesized, and their immunosuppressive effects were evaluated by MTT assay. The experimental data demonstrated that compound 20 showed the strongest inhibition effect (IC50 = 6...
July 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28666866/nmr-uncovers-direct-interaction-between-human-nedd4-1-and-p34-sei-1
#12
Pravesh Shrestha, Ji-Hye Yun, Yoon-Joo Ko, Kyu Jeong Yeon, Dooseop Kim, Heejong Lee, Dong-Hoon Jin, Ki-Yup Nam, Hye Dong Yoo, Weontae Lee
PTEN, an important tumor suppressor and a key regulator of the PI3K/AKT signaling pathway, is often deleted/mutated in different types of cancer. The E3 ubiquitin ligase NEDD4-1 catalyzes the polyubiquitination of PTEN, thereby acting as a negative regulator of PTEN. Stability of NEDD4-1, in turn, is tightly controlled by a 34 kDa oncoprotein, p34(SEI-1) and it regulates PTEN degradation and activates PI3K/AKT pathway, resulting in cancer metastasis. p34(SEI-1) affects not only the expression of NEDD4-1 during transcription and translation but also the subcellular localization of PTEN...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28625920/c-terminal-tail-of-nadph-oxidase-organizer-1-noxo1-mediates-interaction-with-nadph-oxidase-activator-noxa1-in-the-nox1-complex
#13
Pravesh Shrestha, Ji-Hye Yun, Yoon-Joo Ko, Myeongkyu Kim, Yun Soo Bae, Weontae Lee
NOX1 (NADPH oxidase) similar to phagocyte NADPH oxidase, is expressed mainly in the colon epithelium and it is responsible for host defense against microbial infections by generating ROS (reactive oxygen species). NOX1 is activated by two regulatory cytosolic proteins that form a hetero-dimer, Noxo1 (NOX organizer 1) and Noxa1 (NOX activator 1). The interaction between Noxa1 and Noxo1 is critical for activating NOX1. However no structural studies for interaction between Noxa1 and Noxo1 has not been reported till date...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28623061/comparison-of-extraosseous-talotarsal-stabilization-implants-in-a-stage-ii-adult-acquired-flatfoot-model-a-finite-element-analysis
#14
Jian Xu, Xin Ma, Daping Wang, Wei Lu, Weimin Zhu, Kan Ouyang, Haifeng Liu, Hao Li, Luoyong Jiang
Subtalar arthroereisis has been proved to be an efficient method for correcting flexible adult flatfoot. However, the optimal sinus tarsi implant is still debated and yet to be determined. In the present study, we compared the biomechanical effects of type I and II sinus tarsi implants in stage II adult-acquired flatfoot deformity (AAFD). First, a finite element model of stage II AAFD was established in which virtual surgery of subtalar arthroereisis was simulated. The indexes of plantar stress distribution, peak von Mises of the medial and lateral columns, strain of the medial ligaments and plantar fascia, arch height, talo-first metatarsal angle, calcaneus pitch angle, talonavicular coverage angle, and hindfoot valgus angle were all compared and analyzed...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28587475/management-of-severe-equinovalgus-in-patients-with-cerebral-palsy-by-naviculectomy-in-combination-with-midfoot-arthrodesis
#15
Chakravarthy U Dussa, Leonhard Döderlein, Raimund Forst, H Böhm, Albert Fujak
BACKGROUND: Equinovalgus deformity is the second most common deformity in cerebral palsy and may be flexible or rigid. Several operative methods from joint sparing to arthrodesis have been described with varying success rates. The aim of this study was to investigate the effectiveness of naviculectomy in combination with midfoot arthrodesis (talo-cuneiform and calcaneocuboid arthrodesis) in the correction of a rigid equinovalgus foot deformity in cerebral palsy. METHODS: Forty-eight rigid equinovalgus feet were operated upon in 30 patients from 2008 to 2013...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28513101/industrialization-of-a-perfusion-bioreactor-prime-example-of-a-non-straightforward-process
#16
G Talò, C Turrisi, C Arrigoni, C Recordati, I Gerges, M Tamplenizza, A Cappelluti, S A Riboldi, M Moretti
Bioreactors are essential enabling technologies for the translation of Advanced Therapies Medicinal Products (ATMPs) from the research field towards a successful clinical application. In order to speed up the translation and the spreading of novel Tissue Engineering (TE) products into the clinical routine, TE bioreactors should evolve from laboratory prototypes towards industrialized products. In this work, we thus challenged the industrialization process of a novel technological platform, based on an established research prototype of perfusion bioreactor, following a GMP-driven approach...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28487048/relationship-between-grading-with-magnetic-resonance-imaging-and-radiographic-parameters-in-posterior-tibial-tendon-dysfunction
#17
Kazuya Ikoma, Yusuke Hara, Masamitsu Kido, Kan Imai, Masahiro Maki, Suzuyo Ohashi, Toshikazu Kubo
The objective of the present study was to elucidate the relationship between the state of the posterior tibial tendon (PTT) on magnetic resonance images and foot deformity. The cases included 34 feet in 27 patients with PTT deformity and the controls included 18 feet in 12 patients who had undergone magnetic resonance imaging for other foot diseases. The PTT was closely examined on the magnetic resonance images and classified using the Conti classification. The control feet with no injury to the PTT were classified as grade 0...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28474963/limits-of-calcaneal-lengthening-for-treating-planovalgus-foot-deformity-in-children-with-cerebral-palsy
#18
Chi-An Luo, Hsuan-Kai Kao, Wei-Chun Lee, Wen-E Yang, Chia-Hsieh Chang
BACKGROUND: Calcaneal lengthening is used to correct symptomatic planovalgus foot deformity, but outcomes have been less satisfactory in children with cerebral palsy. This study aimed to define limits of calcaneal lengthening by analyzing the risk factors for undercorrection of deformity. METHODS: We retrospectively reviewed 20 cases of children with cerebral palsy who underwent calcaneal lengthening of 30 planovalgus feet at a mean age of 11.9 years. Foot deformities were evaluated by the anteroposterior talo-first metatarsal angle (normal, 10 ± 7...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28442207/tibio-talo-calcaneal-fusion-after-limb-salvage-procedures-a-retrospective-study
#19
Lukas Zak, Gerald E Wozasek
BACKGROUND: The treatment of limb threatening trauma on the distal tibia or hindfoot often results in posttraumatic osteoarthritis requiring tibiotalocalcaneal (TTC) arthrodesis. The purpose of this study was to present a case series of patients undergoing various techniques of joint fusion after bone reconstruction and deformity correction as a salvage procedure. The study should help trauma surgeons making decisions in limb salvage and deformity correction in complex lower leg and foot injuries by presenting options and treatment strategies...
July 2017: Injury
https://www.readbyqxmd.com/read/28429718/a-computational-systems-approach-identifies-synergistic-specification-genes-that-facilitate-lineage-conversion-to-prostate-tissue
#20
Flaminia Talos, Antonina Mitrofanova, Sarah K Bergren, Andrea Califano, Michael M Shen
To date, reprogramming strategies for generating cell types of interest have been facilitated by detailed understanding of relevant developmental regulatory factors. However, identification of such regulatory drivers often represents a major challenge, as specific gene combinations may be required for reprogramming. Here we show that a computational systems approach can identify cell type specification genes (master regulators) that act synergistically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue...
April 21, 2017: Nature Communications
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