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https://www.readbyqxmd.com/read/29081861/role-of-surgery-in-management-of-osteo-articular-tuberculosis-of-the-foot-and-ankle
#1
REVIEW
Mandeep Singh Dhillon, Vikas Agashe, Sampat Dumbre Patil
BACKGROUND: Tuberculosis of the foot and ankle still remains to be a significant problem, especially in the developing countries, and with an increase in incidence in immunosuppressed patients. Treatment is mainly medical using multidrug chemotherapy; surgical interventions range from biopsy, synovectomy and debridement, to joint preserving procedures like distraction in early cases, and arthrodesis of hindfoot joints and the ankle in advanced disease with joint destruction. Surgical Options: All procedures should be done after initiating appropriate medical management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29073794/porous-titanium-wedges-in-lateral-column-lengthening-for-adult-acquired-flatfoot-deformity
#2
Spencer H Moore, S Evan Carstensen, M Tyrrell Burrus, Truitt Cooper, Joseph S Park, Venkat Perumal
Lateral column lengthening (LCL) is a common procedure for reconstruction of stage II flexible adult-acquired flatfoot deformity (AAFD). The recent development of porous titanium wedges for this procedure provides an alternative to allograft and autograft. The purpose of this study was to report radiographic and clinical outcomes achieved with porous titanium wedges in LCL. A retrospective analysis of 34 feet in 30 patients with AAFD that received porous titanium wedges for LCL from January 2011 to October 2014...
October 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29064000/-1-h-15-n-13-c-backbone-resonance-assignment-of-the-c-terminal-domain-of-enzyme-i-from-thermoanaerobacter-tengcongensis
#3
Rochelle Rea Dotas, Vincenzo Venditti
Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of essential pathways in bacterial metabolism. EIC undergoes an expanded to compact conformational equilibrium that is regulated by ligand binding and determines the phosphorylation state of the overall PTS. Here, we report the backbone (1)H, (15)N and (13)C chemical shift assignments of the 70 kDa EIC dimer from the thermophilic bacterium Thermoanaerobacter tengcongensis...
October 24, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29041945/double-calcaneal-osteotomy-for-severe-adolescent-flexible-flatfoot-reconstruction
#4
Yang Xu, Yong-Xing Cao, Xing-Chen Li, Yuan Zhu, Xiang-Yang Xu
BACKGROUND: The timing and strategy of treatment for flatfoot still remain controversial. It is a difficult problem when facing severe adolescent flexible flatfoot because a single procedure cannot realign flatfoot deformity effectively. METHODS: We reviewed 13 adolescent flexible flatfoot patients who underwent double calcaneal osteotomy during May 2012 to June 2015. The mean age of patients was 15.2 ± 1.8 (range, 10-18) years. The American Orthopaedic Foot and Ankle Society Ankle-Hindfoot (AOFAS-AH) scores and SF-36 score were adopted to evaluate the preoperative and postoperative functions of the foot...
October 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29029989/the-effect-of-demographic-and-disease-variables-on-schneiderian-membrane-thickness-and-appearance
#5
Tuba Talo Yildirim, Güliz Nigar Güncü, Dincer Göksülük, Melek Didem Tözüm, Mehmet Colak, Tolga Fikret Tözüm
OBJECTIVES: The purpose of this study was to evaluate the prevalence of sinus mucosal thickening (MT) and mucosal appearance (MA) in a patient population as detected with cone beam computed tomography (CBCT) and to determine the effects of various disease and demographic factors on MT and MA. STUDY DESIGN: The retrospective study consisted of CBCT images of 1000 maxillary arches in 500 patients. The arches were divided into 3 groups (atrophic, partially atrophic, and nonatrophic) according to the type of the maxillary dental crest...
September 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28980143/nmr-assignments-of-the-n-terminal-domain-of-staphylococcus-aureus-hibernation-promoting-factor-sahpf
#6
Konstantin S Usachev, Rustam Kh Ayupov, Shamil Z Validov, Iskander Sh Khusainov, Marat M Yusupov
Staphylococcus aureus: hibernation-promoting factor (SaHPF) is a 22.2 kDa stationary-phase protein that binds to the ribosome and turns it to the inactive form favoring survival under stress. Sequence analysis has shown that this protein is combination of two homolog proteins obtained in Escherichia coli-ribosome hibernation promoting factor (HPF) (11,000 Da) and ribosome modulation factor RMF (6500 Da). Binding site of E. coli HPF on the ribosome have been shown by X-ray study of Thermus thermophilus ribosome complex...
October 4, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28940147/backbone-resonance-assignment-of-the-human-uracil-dna-glycosylase-2
#7
Hesna Kara, Luc Ponchon, Serge Bouaziz
The HIV-1 viral protein R (Vpr) is incorporated into virus particle during budding suggesting that its presence in the mature virion is required in the early steps of the virus life cycle in newly infected cells. Vpr is released into the host cell cytoplasm to participate to the translocation of the preintegration complex (PIC) into the nucleus for integration of the viral DNA into the host genome. Actually, Vpr plays a key role in the activation of the transcription of the HIV-1 long terminal repeat (LTR), mediates cell cycle arrest in G2 to M transition, facilitates apoptosis and controls the fidelity of reverse transcription...
September 22, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28893616/does-antero-lateral-ankle-impingement-exist
#8
REVIEW
F Molinier, J Benoist, F Colin, J Padiolleau, S Guillo, J Stone, T Bauer
Antero-lateral ankle impingement syndrome (ALAIS) is a well-established clinical entity that is a common consequence of ankle sprains. Injury to the anterior talo-fibular ligament plays a key role in the genesis of ALAIS. Arthroscopic antero-lateral synovectomy is the standard of care. However, this treatment approach may deserve to be challenged, as it does not include any procedure on the ligaments, despite the presence in some patients of lateral rotational micro-instability of the ankle, without objective laxity...
September 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28883689/lateral-column-lengthening-for-adolescent-idiopathic-pes-planovalgus-deformity-systematic-review
#9
REVIEW
Sanjay Kumar, S V Sonanis
Pes planovalgus is the commonest foot deformity in children and presents with wide range of severity and symptoms. Surgery is mostly indicated for significant malalignment, resistant to non-surgical management. Lateral column lengthening is considered an appealing option as does not involve arthrodesis and allows for further growth and foot development. METHODS: We conducted a systematic review on lateral column lengthening for pes planovalgus deformity in line with PRISMA-P Checklist...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28883012/fibular-insufficiency-fracture-an-under-reported-complication-of-advanced-tibialis-posterior-dysfunction
#10
Suresh Srinivasan, Harish Kurup
We present a case of fibular insufficiency (stress) fracture in a patient with pre-existing asymptomatic advanced tibialis posterior dysfunction. The patient had severe planovalgus (flat foot) deformity but no pain before the injury; hence had never sought any treatment. She was first treated conservatively for the fracture which failed to control the deformity and had ongoing symptoms. She eventually required tibio-talo-calcaneal fusion. To the best of our knowledge, this is the first case report of this condition in the English literature...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28877167/measuring-dispositional-flow-validity-and-reliability-of-the-dispositional-flow-state-scale-2-italian-version
#11
Eleonora F M Riva, Giuseppe Riva, Cosimo Talò, Marco Boffi, Nicola Rainisio, Linda Pola, Barbara Diana, Daniela Villani, Luca Argenton, Paolo Inghilleri
OBJECTIVE: The aim of this study is to evaluate the psychometric properties of the Italian version of the Dispositional Flow Scale-2 (DFS-2), for use with Italian adults, young adults and adolescents. METHOD: In accordance with the guidelines for test adaptation, the scale has been translated with the method of back translation. The understanding of the item has been checked according to the latest standards on the culturally sensitive translation. The scale thus produced was administered to 843 individuals (of which 60...
2017: PloS One
https://www.readbyqxmd.com/read/28875416/nmr-study-of-non-structural-proteins-part-iii-1-h-13-c-15-n-backbone-and-side-chain-resonance-assignment-of-macro-domain-from-chikungunya-virus-chikv
#12
Michail V Lykouras, Aikaterini C Tsika, Julie Lichière, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A Spyroulias
Macro domains are conserved protein domains found in eukaryotic organisms, bacteria, and archaea as well as in certain viruses. They consist of 130-190 amino acids and can bind ADP-ribose. Although the exact role of these domains is not fully understood, the conserved binding affinity for ADP-ribose indicates that this ligand is important for the function of the domain. Such a macro domain is also present in the non-structural protein 3 (nsP3) of Chikungunya Alphavirus (CHIKV) and consists of 160 amino acids...
September 5, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28866776/-1-h-15-n-13-c-backbone-resonance-assignments-of-human-phosphoglycerate-kinase-in-a-transition-state-analogue-complex-with-adp-3-phosphoglycerate-and-magnesium-trifluoride
#13
Zhalgas Serimbetov, Nicola J Baxter, Matthew J Cliff, Jonathan P Waltho
Human phosphoglycerate kinase (PGK) is an energy generating glycolytic enzyme that catalyses the transfer of a phosphoryl group from 1,3-bisphosphoglycerate (BPG) to ADP producing 3-phosphoglycerate (3PG) and ATP. PGK is composed of two α/β Rossmann-fold domains linked by a central α-helix and the active site is located in the cleft formed between the N-domain which binds BPG or 3PG, and the C-domain which binds the nucleotides ADP or ATP. Domain closure is required to bring the two substrates into close proximity for phosphoryl transfer to occur, however previous structural studies involving a range of native substrates and substrate analogues only yielded open or partly closed PGK complexes...
October 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28826290/associations-of-alveolar-bone-loss-and-interleukin-1%C3%AE-levels-in-one-and-two-stage-surgical-procedures-a-randomized-prospective-trial
#14
Tuba Talo Yildirim, Filiz Acun Kaya, Beran Yokus, Mehmet Colak, Eylem Ozdemir Kaya, Giray Tekin, Ebru Saribas, Ersin Uysal, Guliz N Guncu
OBJECTIVE: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1β levels in one- and two-stage surgical procedures. MATERIALS AND METHODS: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II)...
November 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28815423/backbone-and-side-chain-1-h-15-n-and-13-c-resonance-assignments-of-a-novel-staphylococcal-inhibitor-of-myeloperoxidase
#15
Nicoleta T Ploscariu, Alvaro I Herrera, Srinivas Jayanthi, Thallapuranam K Suresh Kumar, Brian V Geisbrecht, Om Prakash
The bacterium Staphylococcus aureus produces an array of anti-inflammatory molecules that prevent the innate immune system from recognizing it as a pathogen and clearing it from the host. In the acute phase of inflammation, our immune system relies on neutrophils to clear invading bacteria. Recently, novel classes of secreted proteins from S. aureus, including the Extracellular Adherence Protein (EAP) family (Stapels et al., Proc Natl Acad Sci USA 111:13187-13192, 2014) and the Staphylococcal Peroxidase Inhibitor (SPIN), (unpublished work) have been identified as highly selective inhibitors acting on Neutrophil Serine Proteases (NSPs) and myeloperoxidase (MPO) respectively...
October 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28808891/nmr-backbone-resonance-assignment-of-new-delhi-metallo-beta-lactamase
#16
Chendie Yao, Qiong Wu, Guohua Xu, Conggang Li
The emerging of the New Delhi metallo-beta-lactamase (NDM-1) has become one of the greatest threats to the clinical treatment. Although the structure of NDM-1 has been determined by X-ray crystallography, the molecular mechanism and process of catalysis reaction remain elusive. NMR spectroscopy plays a unique role in the characterization of conformational dynamics. Here we report the backbone (1)H, (15)N and (13)C chemical shift assignments of NDM-1 by heteronuclear multidimensional NMR spectroscopy as well as its secondary structure in solution as predicted by TALOS+...
October 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28698915/surgical-treatment-of-stage-ii-posterior-tibialis-tendon-dysfunction-ten-year-clinical-and-radiographic-results
#17
Alberto Ruffilli, Francesco Traina, Sandro Giannini, Roberto Buda, Fabrizio Perna, Cesare Faldini
INTRODUCTION: Grade II chronic tibialis posterior tendon dysfunction (PTTD) poses a reconstructive challenge to the orthopaedic surgeon. Aim of this retrospective study is to report the clinical and radiographical results of a case series of 63 patients (102 ft) affected by grade II PTTD who underwent tailored surgical treatment at 10-year mean follow-up. MATERIALS AND METHODS: Sixty-three patients (102 ft) were available for clinical and radiological evaluation and were retrospectively reviewed at a mean follow-up of 125...
July 11, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28670651/synthesis-and-biological-evaluation-of-n-arylated-lactam-type-iminosugars-as-potential-immunosuppressive-agents
#18
Hai-Qian Liu, Cheng-Cheng Song, You-Hong Niu, Tao Li, Qin Li, Xin-Shan Ye
Since the immunosuppressive agents currently used in clinics have significant side effects, it is very important to search for new effective and safe immunosuppressants. Iminosugars as a new class of immunosuppressants are less explored. In this report, 24 new N-arylated iminosugar derivatives, including d-talo and d-galacto epimers, were designed and synthesized, and their immunosuppressive effects were evaluated by MTT assay. The experimental data demonstrated that compound 20 showed the strongest inhibition effect (IC50 = 6...
July 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28666866/nmr-uncovers-direct-interaction-between-human-nedd4-1-and-p34-sei-1
#19
Pravesh Shrestha, Ji-Hye Yun, Yoon-Joo Ko, Kyu Jeong Yeon, Dooseop Kim, Heejong Lee, Dong-Hoon Jin, Ki-Yup Nam, Hye Dong Yoo, Weontae Lee
PTEN, an important tumor suppressor and a key regulator of the PI3K/AKT signaling pathway, is often deleted/mutated in different types of cancer. The E3 ubiquitin ligase NEDD4-1 catalyzes the polyubiquitination of PTEN, thereby acting as a negative regulator of PTEN. Stability of NEDD4-1, in turn, is tightly controlled by a 34 kDa oncoprotein, p34(SEI-1) and it regulates PTEN degradation and activates PI3K/AKT pathway, resulting in cancer metastasis. p34(SEI-1) affects not only the expression of NEDD4-1 during transcription and translation but also the subcellular localization of PTEN...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28625920/c-terminal-tail-of-nadph-oxidase-organizer-1-noxo1-mediates-interaction-with-nadph-oxidase-activator-noxa1-in-the-nox1-complex
#20
Pravesh Shrestha, Ji-Hye Yun, Yoon-Joo Ko, Myeongkyu Kim, Yun Soo Bae, Weontae Lee
NOX1 (NADPH oxidase) similar to phagocyte NADPH oxidase, is expressed mainly in the colon epithelium and it is responsible for host defense against microbial infections by generating ROS (reactive oxygen species). NOX1 is activated by two regulatory cytosolic proteins that form a hetero-dimer, Noxo1 (NOX organizer 1) and Noxa1 (NOX activator 1). The interaction between Noxa1 and Noxo1 is critical for activating NOX1. However no structural studies for interaction between Noxa1 and Noxo1 has not been reported till date...
August 26, 2017: Biochemical and Biophysical Research Communications
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