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https://www.readbyqxmd.com/read/27908492/fragility-fractures-of-the-ankle-in-the-elderly-open-reduction-and-internal-fixation-versus-tibio-talo-calcaneal-nailing-short-term-results-of-a-prospective-randomized-controlled-study
#1
D Georgiannos, V Lampridis, I Bisbinas
INTRODUCTION: The management of ankle fractures in the elderly remains unpredictable, secondary to their various co-morbidities. Although tibiotalocalcaneal (TTC) nailing has been an effective option for ankle arthrodesis due to ankle arthritis or Charcot arthropathy there are few reports regarding the use of TTC nail for the treatment of ankle fractures. PURPOSE: Aim of this study was to compare the results of ORIF versus TTC nailing for the treatment of unstable ankle fractures in the elderly...
November 17, 2016: Injury
https://www.readbyqxmd.com/read/27823996/evaluation-of-safety-and-efficacy-of-qinming8631-dr-implantable-cardiac-pacemaker-in-chinese-patients-a-prospective-multicenter-randomized-controlled-trial-of-the-first-domestically-developed-pacemaker-of-china
#2
Mei-Xiang Xiang, Dong-Qi Wang, Jing Xu, Zheng Zhang, Jian-Xin Hu, Dong-Mei Wang, Xiang Gu, He-Ping Liu, Tao Guo, Xiang-Jun Yang, Feng Ling, Jia-Feng Lin, Shang-Lang Cai, Guo-Bin Zhu, Jian-An Wang
BACKGROUND: High cost of imported pacemakers is a main obstacle for Chinese patients suffering from bradyarrhythmia, and a domestically developed pacemaker will help lower the burden. This study aimed to evaluate the safety and efficacy of Qinming8631 DR (Qinming Medical, Baoji, China), the first domestically developed dual-chamber pacemaker of China, compared with a commercially available pacemaker Talos DR (Biotronik, Berlin, Germany) in Chinese patients. METHODS: A prospective randomized trial was conducted at 14 centers in China...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27810026/does-osteoarthritis-of-the-ankle-joint-progress-after-triple-arthrodesis-a-midterm-prospective-outcome-study
#3
Chris A M Aarts, Petra J C Heesterbeek, Perry E M Jaspers, Mark Stegeman, Jan Willem K Louwerens
BACKGROUND: Debate exists regarding the effect of triple fusion on the development of osteoarthritis (OA) of the ankle joint. The midterm outcome after triple arthrodesis and the prevalence of OA following triple arthrodesis are reported in this study. The role of alignment in the development of OA was investigated. METHODS: Seventy five patients (87 feet) were evaluated in 2003 and of these, 48 patients (55 feet) were available for second evaluation in 2008. X-rays of the ankles and feet were made prior to surgery, in 2003 and in 2008, and the level of osteoarthritis (OA) was graded with the Kellgren and Lawrence score...
December 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27796800/is-pes-cavus-alignment-associated-with-lisfranc-injuries-of-the-foot
#4
Jeremy D Podolnick, Daniel S Donovan, Nicholas DeBellis, Alejandro Pino
BACKGROUND: Lisfranc (tarsometatarsal joint) injuries are relatively rare, accounting for less than 1% of all fractures, and as many as 20% of subtle Lisfranc injuries are missed at the initial patient presentation. An undiagnosed Lisfranc injury can have devastating consequences to the patient. Therefore, any factor that can raise a clinician's index of suspicion to make this diagnosis is potentially important. The cavus foot has been associated with various maladies of the lower extremity, but to our knowledge, it has not been reported to be associated with Lisfranc injury...
October 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27721087/selective-activation-of-lower-leg-muscles-during-maximum-voluntary-isometric-contractions
#5
Marco Hagen, Gerrit Schwiertz, Karl B Landorf, Hylton B Menz, George S Murley
The pronators and supinators play a key role in the medio-lateral stability of the ankle joint complex (i.e. talo-crural and subtalar joints). We hypothesized that each shank muscle has a specific activation pattern determined by its anatomical course around the axes of the subtalar and talo-crural joints. A secondary objective was to examine the effect of foot posture on these activation patterns. Forty-nine young adults (25 normal-arched feet, 24 flat-arched feet) performed maximum voluntary isometric contractions against manual resistance in four movement directions: plantarflexion (PF), dorsiflexion (DF), pronation (PRO) and supination (SUP)...
December 2016: Human Movement Science
https://www.readbyqxmd.com/read/27718385/tuberculosis-around-the-tarsal-navicular-a-rare-entity
#6
Vipul Vijay, Nishint Gupta, Raju Vaishya
Osteoarticular TB around the tarsal navicular is a chronic, uncommon condition affecting the midfoot, which causes significant morbidity to the patient. Tuberculosis around the tarsal navicular is rarely described in the literature. A series of three cases - two involving the talo-navicular joint and one involving the naviculo-cuneiform joint is described. Biopsy was used in all the cases for achieving diagnosis. All patients had good to fair outcome following medical management with anti-tubercular therapy...
August 2016: Foot
https://www.readbyqxmd.com/read/27714507/nmr-assignments-of-the-gacs-histidine-kinase-periplasmic-detection-domain-from-pseudomonas-aeruginosa-pao1
#7
Ahmad Ali-Ahmad, Olivier Bornet, Firas Fadel, Yves Bourne, Florence Vincent, Christophe Bordi, Françoise Guerlesquin, Corinne Sebban-Kreuzer
Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen. It can infect vulnerable patients such as those with cystic fibrosis or hospitalized in intensive care units where it is responsible for both acute and chronic infection. The switch between these infections is controlled by a complex regulatory system involving the central GacS/GacA two-component system that activates the production of two small non-coding RNAs. GacS is a histidine kinase harboring one periplasmic detection domain, two inner-membrane helices and three H1/D1/H2 cytoplasmic domains...
October 6, 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/27693943/synthesis-and-antiproliferative-activity-of-peracetylated-2-amino-1-2-dideoxy-1-nitro-d-glycero-l-manno-and-d-glycero-d-talo-heptitols
#8
Verónica Luque-Agudo, Ana María González Gutiérrez, Irene Lagunes, Federico López Galindo, José M Padrón, Emilio Román, José Antonio Serrano, María Victoria Gil
Michael additions between carbohydrate derived nitroalkenes and several aliphatic and aromatic amines proceeded in a stereoselective way, leading to peracetylated 2-amino-1,2-dideoxy-1-nitro-heptitols. In addition, the antiproliferative activity of some of the new adducts has been studied. The results allowed to identify lead compounds which show GI50 values in the range 1.7-19μM.
September 23, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27630944/evaluating-the-relationship-of-dental-fear-with-dental-health-status-and-awareness
#9
Tuba Talo Yildirim
INTRODUCTION: Dental fear is one of the most common problems in dentistry, for both the patient and for the dentist. This issue can have an important effect on an individual's dental health. AIM: The aim of this paper was to report on the prevalence of dental anxiety and to explore if high levels of anxiety are associated with sociodemographic factors, oral health status, and level of oral health awareness. MATERIALS AND METHODS: The sample for this cross-sectional study included 294 patients (154 males and 140 females)...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27624767/nmr-study-of-met-1-human-angiogenin-1-h-13-c-15-n-backbone-and-side-chain-resonance-assignment
#10
Aikaterini C Tsika, Demetra S M Chatzileontiadou, Demetres D Leonidas, Georgios A Spyroulias
Here, we report the high yield expression and preliminary structural analysis via solution hetero-nuclear NMR spectroscopy of the recombinant Met-1 human Angiogenin. The analysis reveals a well folded as well as, a monomeric polypeptide. Τhe sequence-specific assignment of its (1)H, (15)N and (13)C resonances at high percentage was obtained. Also, using TALOS+ its secondary structure elements were determined.
October 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/27600487/pedobarographic-and-radiological-analysis-after-treating-a-talus-neck-fracture
#11
Tuğba Kuru Çolak, İlker Çolak, Eren Timurtaş, Güven Bulut, M Gülden Polat
Misalignment of the talar neck after surgical repair can redistribute the load among the posterior, middle, and anterior facets of the subtalar joints, which can change the joint biomechanics, cause arthritis, and impair function. However, we found no studies analyzing the plantar pressures after treatment of talus neck fracture. We determined the dynamic plantar pedobarographic and radiographic characteristics and ankle range of motion, function, and pain among patients after surgical repair of talar neck fractures...
September 2, 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27584727/interstitial-perfusion-culture-with-specific-soluble-factors-inhibits-type-i-collagen-production-from-human-osteoarthritic-chondrocytes-in-clinical-grade-collagen-sponges
#12
Nathalie Mayer, Silvia Lopa, Giuseppe Talò, Arianna B Lovati, Marielle Pasdeloup, Stefania A Riboldi, Matteo Moretti, Frédéric Mallein-Gerin
Articular cartilage has poor healing ability and cartilage injuries often evolve to osteoarthritis. Cell-based strategies aiming to engineer cartilaginous tissue through the combination of biocompatible scaffolds and articular chondrocytes represent an alternative to standard surgical techniques. In this context, perfusion bioreactors have been introduced to enhance cellular access to oxygen and nutrients, hence overcoming the limitations of static culture and improving matrix deposition. Here, we combined an optimized cocktail of soluble factors, the BIT (BMP-2, Insulin, Thyroxin), and clinical-grade collagen sponges with a bidirectional perfusion bioreactor, namely the oscillating perfusion bioreactor (OPB), to engineer in vitro articular cartilage by human articular chondrocytes (HACs) obtained from osteoarthritic patients...
2016: PloS One
https://www.readbyqxmd.com/read/27539854/characterization-of-a-novel-d-glycero-d-talo-oct-2-ulosonic-acid-substituted-lipid-a-moiety-in-the-lipopolysaccharide-produced-by-the-acetic-acid-bacterium-acetobacter-pasteurianus-nbrc-3283
#13
Masahito Hashimoto, Mami Ozono, Maiko Furuyashiki, Risako Baba, Shuhei Hashiguchi, Yasuo Suda, Koichi Fukase, Yukari Fujimoto
Acetobacter pasteurianus is an aerobic Gram-negative rod that is used in the fermentation process used to produce the traditional Japanese black rice vinegar kurozu. Previously, we found that a hydrophobic fraction derived from kurozu stimulates Toll-like receptors to produce cytokines. LPSs, particularly LPS from A. pasteurianus, are strong candidates for the immunostimulatory component of kurozu. The LPS of A. pasteurianus remains stable in acidic conditions during the 2 years of the abovementioned fermentation process...
September 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27518566/identification-of-causal-genetic-drivers-of-human-disease-through-systems-level-analysis-of-regulatory-networks
#14
James C Chen, Mariano J Alvarez, Flaminia Talos, Harshil Dhruv, Gabrielle E Rieckhof, Archana Iyer, Kristin L Diefes, Kenneth Aldape, Michael Berens, Michael M Shen, Andrea Califano
No abstract text is available yet for this article.
August 11, 2016: Cell
https://www.readbyqxmd.com/read/27472719/autograft-versus-sterilized-allograft-for-lateral-calcaneal-lengthening-osteotomies-comparison-of-50-patients
#15
Sebastian A Müller, Alexej Barg, Patrick Vavken, Victor Valderrabano, Andreas M Müller
Sterilized allografts may be less resistant to collapse and prone to nonunion leading to loss of correction in open wedge osteotomies. These adverse events usually occur at early time points (i.e., < 9 months postoperatively). The goal of this study was to compare sterilized allografts to autologous grafts in respect to secondary loss of hindfoot alignment and graft incorporation after lateral calcaneal lengthening osteotomies.Fifty patients (22 F/ 28 M, age: 16-69 years) who had undergone 50 lateral calcaneal lengthening osteotomies for adult flatfoot deformity were included in this retrospective study...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27417066/cell-microenvironment-interactions-and-architectures-in-microvascular-systems
#16
REVIEW
Simone Bersini, Iman K Yazdi, Giuseppe Talò, Su Ryon Shin, Matteo Moretti, Ali Khademhosseini
In the past decade, significant advances have been made in the design and optimization of novel biomaterials and microfabrication techniques to generate vascularized tissues. Novel microfluidic systems have facilitated the development and optimization of in vitro models for exploring the complex pathophysiological phenomena that occur inside a microvascular environment. To date, most of these models have focused on engineering of increasingly complex systems, rather than analyzing the molecular and cellular mechanisms that drive microvascular network morphogenesis and remodeling...
November 1, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/27402620/calcaneal-z-lengthening-osteotomy-combined-with-subtalar-arthroereisis-for-severe-adolescent-flexible-flatfoot-reconstruction
#17
Yang Xu, Xing-Chen Li, Xiang-Yang Xu
BACKGROUND: The timing and strategy for operative treatment of flatfoot are still controversial. The purpose of this study was to evaluate clinical outcomes and radiographic changes following calcaneal Z osteotomy combined with subtalar arthroereisis for severe adolescent flexible flatfoot. METHODS: Data were analyzed for 16 patients (20 feet) who had flatfoot without tibialis posterior tendon dysfunction and were treated by calcaneal Z osteotomy combined with arthroereisis between October 2011 and February 2015...
July 9, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27394726/-1-h-13-c-and-15-n-backbone-resonance-assignments-and-dynamic-properties-of-the-pdz-tandem-of-whirlin
#18
Florent Delhommel, Nicolas Wolff, Florence Cordier
Mammals perceive sounds thanks to mechanosensory hair cells located in the inner ear. The stereocilia of these cells are tightly bound together in bundles by a network of cadherins and scaffolding proteins. Stereocilia deflection induces stretching of this network and is responsible for hair cell depolarization that triggers the neuronal message, transducing the mechanical signal into an electric signal transmissible to the brain. Nearly all proteins involved in this mechano-electrical transduction network contain short C-terminal motifs of interaction with PDZ domains (PSD-95, Discs Large, ZO-1)...
October 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/27381590/transient-and-chronic-seizure-induced-inflammation-in-human-focal-epilepsy
#19
Tracy Butler, Yi Li, Wai Tsui, Daniel Friedman, Anat Maoz, Xiuyuan Wang, Patrick Harvey, Emily Tanzi, Simon Morim, Yeona Kang, Lisa Mosconi, Delia Talos, Ruben Kuzniecky, Shankar Vallhabjosula, Thomas Thesen, Lidia Glodzik, Masanori Ichise, David Silbersweig, Emily Stern, Mony J de Leon, Jacqueline French
In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography (PET) using a radiotracer sensitive to brain inflammation in a patient with frontal epilepsy ~36 h after a seizure as well as during a seizure-free period. When statistically compared to a group of 12 matched controls, both of the patient's scans identified a frontal (supplementary motor area) region of increased inflammation corresponding to his clinically defined seizure focus, but the postseizure scan showed significantly greater inflammation intensity and spatial extent...
September 2016: Epilepsia
https://www.readbyqxmd.com/read/27380141/in-vivo-kinematic-study-of-the-tarsal-joints-complex-based-on-fluoroscopic-3d-2d-registration-technique
#20
M D Chen Wang, Xiang Geng, Shaobai Wang, M D Xin Ma, M D Xu Wang, M D Jiazhang Huang, M D Chao Zhang, M S Li Chen, Junsheng Yang, Kan Wang
The tarsal bones articulate with each other and demonstrate complicated kinematic characteristics. The in vivo motions of these tarsal joints during normal gait are still unclear. Seven healthy subjects were recruited and fourteen feet in total were tested in the current study. Three dimensional models of the tarsal bones were first created using CT scanning. Corresponding local 3D coordinate systems of each tarsal bone was subsequently established for 6DOF motion decompositions. The fluoroscopy system captured the lateral fluoroscopic images of the targeted tarsal region whilst the subject was walking...
September 2016: Gait & Posture
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