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https://www.readbyqxmd.com/read/28207272/controlling-the-release-of-indomethacin-from-glass-solutions-layered-with-a-rate-controlling-membrane-using-fluid-bed-processing-part-2-the-influence-of-formulation-parameters-on-drug-release
#1
Aswin Dereymaker, Jirka Pelgrims, Frederick Engelen, Peter Adriaensens, Guy Van den Mooter
This study aimed to investigate the pharmaceutical performance of an indomethacin-polyvinylpyrrolidone (PVP) glass solution applied using fluid bed processing as a layer on inert sucrose spheres, and subsequently top-coated with a release rate controlling membrane consisting of either ethyl cellulose or Eudragit RL. The implications of the addition of a pore former (PVP) and the coating medium (ethanol or water) on the diffusion and release behavior were also considered. In addition, the role of a charge interaction between drug and controlled release polymer on the release was investigated...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28191989/rule-based-reasoning-is-fast-and-belief-based-reasoning-can-be-slow-challenging-current-explanations-of-belief-bias-and-base-rate-neglect
#2
Ian R Newman, Maia Gibb, Valerie A Thompson
It is commonly assumed that belief-based reasoning is fast and automatic, whereas rule-based reasoning is slower and more effortful. Dual-Process theories of reasoning rely on this speed-asymmetry explanation to account for a number of reasoning phenomena, such as base-rate neglect and belief-bias. The goal of the current study was to test this hypothesis about the relative speed of belief-based and rule-based processes. Participants solved base-rate problems (Experiment 1) and conditional inferences (Experiment 2) under a challenging deadline; they then gave a second response in free time...
February 13, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28170100/vulnerable-narcissism-is-mostly-a-disorder-of-neuroticism
#3
Joshua D Miller, Donald R Lynam, Colin Vize, Michael Crowe, Chelsea Sleep, Jessica L Maples-Keller, Lauren R Few, W Keith Campbell
OBJECTIVE: Increasing attention has been paid to the distinction between the dimensions of narcissistic grandiosity and vulnerability. We examine the degree to which basic traits underlie vulnerable narcissism with a particular emphasis on the importance of neuroticism and agreeableness. METHODS: Across four samples (undergraduate, online community, clinical-community), we conduct dominance analyses to partition the variance predicted in vulnerable narcissism by the five-factor model personality domains...
February 7, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28166174/cdc-s-prevention-status-reports-monitoring-the-status-of-public-health-policies-and-practices-for-improved-performance-and-accountability
#4
Andrea C Young, Garry Lowry, Karen Mumford, Christine Graaf
CONTEXT: Increasing the adoption and implementation of evidence-based policies and practices is a key strategy for improving public health. Although there is widespread agreement about the importance of implementing evidence-based public health policies and practices, there are gaps between what has been shown to be effective and what is implemented at the state level. OBJECTIVE: The Centers for Disease Control and Prevention (CDC) developed the Prevention Status Reports (PSRs), a performance measurement system, to highlight evidence-based public health policies and practices and catalyze state performance and quality improvement efforts across the nation...
February 3, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28165271/examination-of-the-feasibility-and-utility-of-flexible-and-conditional-administration-of-the-minnesota-multiphasic-personality-inventory-2-restructured-form
#5
Anthony M Tarescavage, Yossef S Ben-Porath
Over the past several decades, use of broadband personality assessments has decreased, with some clinicians favoring shorter, symptom-focused measures with a shorter administration time. The purpose of this study is to describe, derive rules for, and evaluate a flexible and conditional administration of the Minnesota Multiphasic Personality Inventory (MMPI)-2-Restructured Form (MMPI-2-RF). In this approach, elevated scores on higher level scales are used to trigger administration of lower-level scales within the same assessment domain to minimize administration time...
February 6, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28163368/creating-memories-for-false-autobiographical-events-in-childhood-a-systematic-review
#6
Chris R Brewin, Bernice Andrews
Using a framework that distinguishes autobiographical belief, recollective experience, and confidence in memory, we review three major paradigms used to suggest false childhood events to adults: imagination inflation, false feedback and memory implantation. Imagination inflation and false feedback studies increase the belief that a suggested event occurred by a small amount such that events are still thought unlikely to have happened. In memory implantation studies, some recollective experience for the suggested events is induced on average in 47% of participants, but only in 15% are these experiences likely to be rated as full memories...
January 2017: Applied Cognitive Psychology
https://www.readbyqxmd.com/read/28159526/a-case-of-base-rate-bias-or-are-adolescents-at-a-higher-risk-of-developing-complications-after-catheterizable-urinary-channel-surgery
#7
K M Szymanski, B Whittam, R Misseri, K H Chan, C K Flack, M Kaefer, R C Rink, M P Cain
OBJECTIVE: Adolescents are considered to be at high risk of developing complications after lower genitourinary tract reconstruction. This perception may be due to base rate bias, where clinicians favor specific information (adolescents with complications), while ignoring more general information (number of total adolescents being followed). The goal of this study was to assess whether age was a true risk factor for subfascial and stomal revisions after continent catheterizable urinary (CCU) channel procedures...
January 11, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28145993/neural-correlates-of-decision-making-during-a-bayesian-choice-task
#8
Govinda R Poudel, Anjan Bhattarai, David L Dickinson, Sean P A Drummond
Many critical decisions require evaluation of accumulated previous information and/or newly acquired evidence. Although neural correlates of belief updating have been investigated, how these neural processes guide decisions involving Bayesian choice is less clear. Here, we used functional MRI to investigate neural activity during a Bayesian choice task involving two sources of information: base rate odds ('odds') and sample evidence ('evidence'). Thirty-seven healthy control individuals performed the Bayesian choice task in which they had to make probability judgements...
January 31, 2017: Neuroreport
https://www.readbyqxmd.com/read/28142129/effects-of-surgical-side-and-site-on-psychological-symptoms-following-epilepsy-surgery-in-adults
#9
Brigid E Prayson, Darlene P Floden, Lisa Ferguson, Kevin H Kim, Lara Jehi, Robyn M Busch
This retrospective study examined the potential role of side and site of surgery in psychological symptom change after epilepsy surgery and determined the base rate of psychological change at the individual level. Two-hundred twenty-eight adults completed the Personality Assessment Inventory (PAI) before and after temporal (TLR; n=190) or frontal lobe resection (FLR; n=38). Repeated measures ANOVAs with bootstrapping examined differences in psychological outcome as a function of surgical site separately in patients who underwent left- versus right-sided resections...
January 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28131515/critical-incidents-and-judicial-response-during-medium-security-treatment
#10
Inge Jeandarme, Ciska Wittouck, Freya Vander Laenen, Claudia Pouls, Henri Heimans, T I Oei, Stefan Bogaerts
This study examined inpatient incidents in three Flemish forensic medium security units and analyzed the subsequent judicial reactions to these incidents. During medium security treatment, incidents were reported for more than half of the participants. The most frequently registered incidents were non-violent in nature, such as absconding and treatment non-compliance. The base rate for physically violent incidents was low. Although crime-related incidents during medium security treatment were rarely prosecuted and adjudicated, the base rate of revocation - and hence drop-out from treatment - as a result of these incidents was high...
January 25, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28089676/multimodal-evaluation-of-the-amygdala-s-functional-connectivity
#11
Rebecca Kerestes, Henry W Chase, Mary L Phillips, Cecile D Ladouceur, Simon B Eickhoff
The amygdala is one of the most extensively studied human brain regions and undisputedly plays a central role in many psychiatric disorders. However, an outstanding question is whether connectivity of amygdala subregions, specifically the centromedial (CM), laterobasal (LB) and superficial (SF) nuclei, are modulated by brain state (i.e., task vs. rest). Here, using a multimodal approach, we directly compared meta-analytic connectivity modeling (MACM) and specific co-activation likelihood estimation (SCALE)-derived estimates of CM, LB and SF task-based co-activation to the functional connectivity of these nuclei as assessed by resting state fmri (rs-fmri)...
January 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28080264/convergent-and-criterion-validity-of-the-cogstate-computerized-brief-battery-cognitive-assessment-in-women-with-and-without-breast-cancer
#12
Sunita K Patel, Adrienne M Meier, Nathaniel Fernandez, Tracy T Y Lo, Colleen Moore, Nicole Delgado
OBJECTIVE: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a group known to present with mostly mild, subtle cognitive dysfunction...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28079775/association-of-hospital-volume-with-racial-and-ethnic-disparities-in-locally-advanced-cervical-cancer-treatment
#13
Shitanshu Uppal, Christina Chapman, Ryan J Spencer, Shruti Jolly, Kate Maturen, J Alejandro Rauh-Hain, Marcela G delCarmen, Laurel W Rice
OBJECTIVE: To evaluate racial-ethnic disparities in guideline-based care in locally advanced cervical cancer and their relationship to hospital case volume. METHODS: Using the National Cancer Database, we performed a retrospective cohort study of women diagnosed between 2004 and 2012 with locally advanced squamous or adenocarcinoma of the cervix undergoing definitive primary radiation therapy. The primary outcome was the race-ethnicity-based rates of adherence to the National Comprehensive Cancer Network guideline-based care...
February 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28076970/future-directions-for-work-on-refinement-of-adhd-assessment-in-young-adults
#14
Michelle M Martel, Ulrich Schimmack, Joel T Nigg
Sibley, Coxe, and Molina provide a thoughtful discussion of the implications of our study and highlight important future directions in this line of work. They helpfully amplify several themes that space did not allow discussion of in our article. In particular, they correctly emphasize the importance of theoretical as well as statistical considerations in model selection. We also agree that clinical tests of sensitivity and specificity, taking into account different base rates and types of samples, are essential before a final algorithm would be ready for dissemination...
January 1, 2017: Assessment
https://www.readbyqxmd.com/read/28069853/sharp-decline-in-prostate-cancer-treatment-among-men-in-the-general-population-but-not-among-diagnosed-men
#15
Tudor Borza, Samuel R Kaufman, Vahakn B Shahinian, Phyllis Yan, David C Miller, Ted A Skolarus, Brent K Hollenbeck
The indolent nature of many prostate cancers has heightened concerns that harms from treatment may outweigh those from the disease and has resulted in a growing consensus in favor of less aggressive screening and treatment. We sought to understand the population-level impact of this consensus on the treatment of prostate cancer. Using national Medicare data for the period 2007-12, we assessed treatment rates among men with newly diagnosed prostate cancer. We identified both population-based rates (which are sensitive to changes in diagnosis and treatment patterns) and rates among diagnosed men (which are sensitive only to changes in treatment patterns)...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28068864/reliability-and-sources-of-variation-of-the-abilhand-kids-questionnaire-in-children-with-cerebral-palsy
#16
Lex D de Jong, Annemiek van Meeteren, Cornelis H Emmelot, Nanne E Land, Pieter U Dijkstra
PURPOSE: To determine reliability of the ABILHAND-Kids, explore sources of variation associated with these measurement results, and generate repeatability coefficients. METHOD: A reliability study with a repeated measures design was performed in an ambulatory rehabilitation care department from a rehabilitation center, and a center for special education. A physician, an occupational therapist, and parents of 27 children with spastic cerebral palsy independently rated the children's manual capacity when performing 21 standardized tasks of the ABILHAND-Kids from video recordings twice with a three week time interval (27 first-, and 25 second video recordings available)...
January 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28057683/orcan-a-web-based-meta-server-for-real-time-detection-and-functional-annotation-of-orthologs
#17
Andrzej Zielezinski, Michal Dziubek, Jan Sliski, Wojciech M Karlowski
: ORCAN (ORtholog sCANner) is a web-based meta-server for one-click evolutionary and functional annotation of protein sequences. The server combines information from the most popular orthology-prediction resources, including four tools and four online databases. Functional annotation utilizes five additional comparisons between the query and identified homologs, including: sequence similarity, protein domain architectures, functional motifs, Gene Ontology term assignments and a list of associated articles...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27991774/abatement-of-polychoro-1-3-butadienes-in-aqueous-solution-by-ozone-uv-photolysis-and-advanced-oxidation-processes-o3-h2o2-and-uv-h2o2
#18
Minju Lee, Tony Merle, Daniel Rentsch, Silvio Canonica, Urs von Gunten
The abatement of 9 polychloro-1,3-butadienes (CBDs) in aqueous solution by ozone, UV-C(254 nm) photolysis, and the corresponding advanced oxidation processes (AOPs) (i.e., O3/H2O2 and UV/H2O2) was investigated. The following parameters were determined for 9 CBDs: second-order rate constants for the reactions of CBDs with ozone (kO3) (<0.1-7.9 × 10(3) M(-1) s(-1)) or with hydroxyl radicals (k(•)OH) (0.9 × 10(9) - 6.5 × 10(9) M(-1) s(-1)), photon fluence-based rate constants (k') (210-2730 m(2) einstein(-1)), and quantum yields (Φ) (0...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27981788/plasticity-in-seedling-morphology-biomass-allocation-and-physiology-among-ten-temperate-tree-species-in-response-to-shade-is-related-to-shade-tolerance-and-not-leaf-habit
#19
D J Chmura, J Modrzyński, P Chmielarz, M G Tjoelker
Mechanisms of shade tolerance in tree seedlings, and thus growth in shade, may differ by leaf habit and vary with ontogeny following seed germination. To examine early responses of seedlings to shade in relation to morphological, physiological and biomass allocation traits, we compared seedlings of 10 temperate species, varying in their leaf habit (broadleaved versus needle-leaved) and observed tolerance to shade, when growing in two contrasting light treatments - open (about 20% of full sunlight) and shade (about 5% of full sunlight)...
December 16, 2016: Plant Biology
https://www.readbyqxmd.com/read/27968864/hiv-testing-campaigns-and-treatment-interventions-for-control-of-epidemic-hiv-growth-among-heterosexuals-a-mathematical-modelling-study
#20
Ngai Sze Wong, Ka Hing Wong, Owen T Y Tsang, Man Po Lee, Shui Shan Lee
BACKGROUND: In 2015, WHO recommended universal antiretroviral treatment for HIV irrespective of CD4 cell count. The impact of this recommendation on heterosexual HIV transmission, especially in low prevalence countries, has not been well-characterised. In Hong Kong, 38% of reported HIV cases are heterosexually acquired. We aimed to model the impacts of enhanced HIV testing and immediate treatment to provide a reference to other provinces in China. METHODS: We developed deterministic compartmental models (sexually active heterosexual males and females) for simulation of HIV epidemiology for 1983-2011 in Hong Kong, with data projected to 2012-20...
October 2016: Lancet
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