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https://www.readbyqxmd.com/read/28345444/budgetary-impact-of-cabazitaxel-use-after-docetaxel-treatment-for-metastatic-castration-resistant-prostate-cancer
#1
Kyle Flannery, Ed Drea, Louis Hudspeth, Shelby Corman, Xin Gao, Mei Xue, Raymond Miao
BACKGROUND: With the approval of several new treatments for metastatic castration-resistant prostate cancer (mCRPC), budgetary impact is a concern for health plan decision makers. Budget impact models (BIMs) are becoming a requirement in many countries as part of formulary approval or reimbursement decisions. Cabazitaxel is a second-generation taxane developed to overcome resistance to docetaxel and is approved for the treatment of patients with mCRPC previously treated with a docetaxel-containing regimen...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28343854/effect-of-maryland-s-2011-alcohol-sales-tax-increase-on-alcohol-positive-driving
#2
Marie-Claude Lavoie, Patricia Langenberg, Andres Villaveces, Patricia C Dischinger, Linda Simoni-Wastila, Kathleen Hoke, Gordon S Smith
INTRODUCTION: The 2011 Maryland alcohol sales tax increase from 6% to 9% provided an opportunity to evaluate the impact on rates of alcohol-positive drivers involved in injury crashes. METHODS: Maryland police crash reports from 2001 to 2013 were analyzed using an interrupted time series design and a multivariable analysis employing generalized estimating equations models with a negative binomial distribution. Data were analyzed in 2014-2015. RESULTS: There was a significant gradual annual reduction of 6% in the population-based rate of all alcohol-positive drivers (p<0...
March 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28327290/bayesian-brains-without-probabilities
#3
REVIEW
Adam N Sanborn, Nick Chater
Bayesian explanations have swept through cognitive science over the past two decades, from intuitive physics and causal learning, to perception, motor control and language. Yet people flounder with even the simplest probability questions. What explains this apparent paradox? How can a supposedly Bayesian brain reason so poorly with probabilities? In this paper, we propose a direct and perhaps unexpected answer: that Bayesian brains need not represent or calculate probabilities at all and are, indeed, poorly adapted to do so...
December 2016: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28327225/accurate-perceptions-do-not-need-complete-information-to-reflect-reality
#4
Shabnam Mousavi, David C Funder
Social reality of a group emerges from interpersonal perceptions and beliefs put to action under a host of environmental conditions. By extending the study of fast-and-frugal heuristics, we view social perceptions as judgment tools and assert that perceptions are ecologically rational to the degree that they adapt to the social reality. We maintain that the veracity of both stereotypes and base rates, as judgment tools, can be determined solely by accuracy research.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28306147/early-functional-limitations-in-cognitively-normal-older-adults-predict-diagnostic-conversion-to-mild-cognitive-impairment
#5
Sarah Tomaszewski Farias, Karen Lau, Danielle Harvey, Katherine G Denny, Cheyanne Barba, Anthony N Mefford
OBJECTIVES: To examine whether specific types of early functional limitations in cognitively normal older adults are associated with subsequent development of mild cognitive impairment (MCI), as well as the relative predictive value of self versus informant report in predicting diagnostic conversion to MCI. DESIGN: As a part of a longitudinal study design, participants underwent baseline and annual multidisciplinary clinical evaluations, including a physical and neurological examination, imaging, laboratory work, and neuropsychological testing...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28301439/efficacy-of-the-repetitions-in-reserve-based-rating-of-perceived-exertion-for-the-bench-press-in-experienced-and-novice-benchers
#6
Michael J Ormsbee, Joseph P Carzoli, Alex Klemp, Brittany R Allman, Michael C Zourdos, Jeong-Su Kim, Lynn B Panton
Autoregulation (AR) is the practice of adjusting training variables in response to athlete feedback. One component of AR postulated to enhance resistance training adaptations involves implementing a resistance training-specific rating of perceived exertion (RPE) scale measuring repetitions in reserve (RIR). The purpose of this study was to examine the efficacy of this method using the bench press exercise. METHODS: Twenty-seven college-aged men were assigned to one of two groups based upon training age: experience benchers (EB) (n=14, training age: 4...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28283812/behavioral-treatments-for-post-traumatic-headache
#7
REVIEW
Felicia Fraser, Yuka Matsuzawa, Yuen Shan Christine Lee, Mia Minen
PURPOSE OF REVIEW: Post-traumatic headache (PTH) is a common headache type after traumatic brain injury (TBI). There are no FDA approved medications for PTH, and it is unknown how medications can affect the brain's ability to recover from TBI. Thus, we sought to examine the biopsychosocial factors that influence PTH and the non-pharmacologic treatments studied for headache treatment. We also sought to determine if there is literature examining whether the non-pharmacologic treatments influence the biopsychosocial factors...
May 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28281293/hypomania-checklist-32-cross-validation-of-shorter-versions-screening-for-bipolar-disorders-in-an-epidemiological-study
#8
T D Meyer, E Castelao, M Gholamrezaee, J Angst, M Preisig
OBJECTIVE: Self-reports such as Hypomania Checklist (HCL-32) can be used to enhance recognition of bipolar disorders, but they are often too long and only validated in clinical samples. The objectives of this study are therefore to test whether (i) the HCL-32 can be used for screening in the community and (ii) whether two previously suggested shorter versions would do as well. METHOD: Data stemmed from the CoLaus|PsyColaus, a prospective cohort study which included randomly selected residents aged 35-66 years from an urban area...
March 9, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28276886/design-of-a-gis-based-rating-protocol-to-assess-the-potential-for-landfill-closure-using-dredge-material-in-post-hurricane-sandy-new-jersey
#9
Robert J Miskewitz, Daniel Barone, Sar J Guterl, Christopher G Uchrin
New Jersey is rapidly running out of capacity for storage of dredged material. A potential solution to this lack of storage space is to remove and reuse the dredged material for some beneficial use. Results from a Rutgers University project performed for the New Jersey Department of Transportation, Office of Maritime Resources, designed to assess the potential for closure of New Jersey landfills using dredge material from existing Confined Disposal Facilities (CDFs) are presented and discussed. The project included an update of the existing NJDEP landfill database, the development of a rating system to identify landfills with the highest potential to utilize dredged material for their closure, and the identification and preliminary investigation of the top candidate landfills based on this rating system...
February 22, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28276861/screening-for-dementia-in-arabic-normative-data-from-an-elderly-lebanese-sample
#10
Fadi Abou-Mrad, Gordon Chelune, Edward Zamrini, Lubna Tarabey, Maryse Hayek, Patricia Fadel
OBJECTIVE: Prevention and treatment of dementia is a global concern that requires involvement of international samples. The purpose of this study is to develop culturally sensitive norms based on normal older Lebanese adults using multiple cognitive screening measures translated into Arabic for regional use. METHODS: Participants were 164 community dwelling older Lebanese adults without cognitive complaints. They were administered the following cognitive measures in Arabic: Alzheimer's Disease 8-item questionnaire, Montreal Cognitive Assessment, Mini Mental Status Exam, Modified Mini Mental Status, Brief Visuospatial Memory Test-Revised, Lebanese Digit Span, Cross-Linguistic Naming Test, and phonemic and semantic fluency tests...
February 23, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28274905/a-learning-health-care-system-using-computer-aided-diagnosis
#11
Amos Cahan, James J Cimino
Physicians intuitively apply pattern recognition when evaluating a patient. Rational diagnosis making requires that clinical patterns be put in the context of disease prior probability, yet physicians often exhibit flawed probabilistic reasoning. Difficulties in making a diagnosis are reflected in the high rates of deadly and costly diagnostic errors. Introduced 6 decades ago, computerized diagnosis support systems are still not widely used by internists. These systems cannot efficiently recognize patterns and are unable to consider the base rate of potential diagnoses...
March 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28261135/impression-management-and-interview-and-job-performance-ratings-a-meta-analysis-of-research-design-with-tactics-in-mind
#12
Jessica A Peck, Julia Levashina
Impression management (IM) is pervasive in interview and job performance settings. We meta-analytically examine IM by self- and other-focused tactics to establish base rates of tactic usage, to understand the impact of tactics on interview and job performance ratings, and to examine the moderating effects of research design. Our results suggest IM is used more frequently in the interview rather than job performance settings. Self-focused tactics are more effective in the interview rather than in job performance settings, and other-focused tactics are more effective in job performance settings rather than in the interview...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28257840/non-invasive-imaging-of-the-levels-and-effects-of-glutathione-on-the-redox-status-of-mouse-brain-using-electron-paramagnetic-resonance-imaging
#13
Miho C Emoto, Yuta Matsuoka, Ken-Ichi Yamada, Hideo Sato-Akaba, Hirotada G Fujii
Glutathione (GSH) is the most abundant non-protein thiol that buffers reactive oxygen species in the brain. GSH does not reduce nitroxides directly, but in the presence of ascorbates, addition of GSH increases ascorbate-induced reduction of nitroxides. In this study, we used electron paramagnetic resonance (EPR) imaging and the nitroxide imaging probe, 3-methoxycarbonyl-2,2,5,5-tetramethyl-piperidine-1-oxyl (MCP), to non-invasively obtain spatially resolved redox data from mouse brains depleted of GSH with diethyl maleate compared to control...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28254237/prediction-of-advertisement-preference-by-fusing-eeg-response-and-sentiment-analysis
#14
Himaanshu Gauba, Pradeep Kumar, Partha Pratim Roy, Priyanka Singh, Debi Prosad Dogra, Balasubramanian Raman
This paper presents a novel approach to predict rating of video-advertisements based on a multimodal framework combining physiological analysis of the user and global sentiment-rating available on the internet. We have fused Electroencephalogram (EEG) waves of user and corresponding global textual comments of the video to understand the user's preference more precisely. In our framework, the users were asked to watch the video-advertisement and simultaneously EEG signals were recorded. Valence scores were obtained using self-report for each video...
February 16, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28252976/trial-1-versus-trial-2-of-the-test-of-memory-malingering-evaluating-accuracy-without-a-gold-standard
#15
Douglas Mossman, Dustin B Wygant, Roger O Gervais, Kathleen J Hart
This study examines the accuracy of the Test of Memory Malingering (TOMM), a frequently administered measure for evaluating effort during neurocognitive testing. In the last few years, several authors have suggested that the initial recognition trial of the TOMM (Trial 1) might be a more useful index for detecting feigned or exaggerated impairment than Trial 2, which is the source for inference recommended by the original instruction manual (Tombaugh, 1996). We used latent class modeling (LCM) implemented in a Bayesian framework to evaluate archival Trial 1 and Trial 2 data collected from 1,198 adults who had undergone outpatient forensic evaluations...
March 2, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28243948/gestalt-assessment-of-online-educational-resources-may-not-be-sufficiently-reliable-and-consistent
#16
Keeth Krishnan, Brent Thoma, N Seth Trueger, Michelle Lin, Teresa M Chan
PURPOSE: Online open educational resources are increasingly used in medical education, particularly blogs and podcasts. However, it is unclear whether these resources can be adequately appraised by end-users. Our goal was to determine whether gestalt-based recommendations are sufficient for emergency medicine trainees and attending physicians to reliably recommend online educational resources to others. METHODS: Raters (33 trainees and 21 attendings in emergency medicine from North America) were asked to rate 40 blog posts according to whether, based on their gestalt, they would recommend the resource to (1) a trainee or (2) an attending physician...
February 27, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28236684/near-miss-experiences-of-transport-and-recreational-cyclists-in-new-south-wales-australia-findings-from-a-prospective-cohort-study
#17
R G Poulos, J Hatfield, C Rissel, L K Flack, L Shaw, R Grzebieta, A S McIntosh
This paper investigates events in which cyclists perceive a cycling crash is narrowly avoided (henceforth, a near miss). A cohort of 2038 adult transport and recreational cyclists from New South Wales (Australia) provided self-reported prospectively collected data from cycling diaries to allow the calculation of an exposure-based rate of near misses and investigation of near miss circumstances. During 25,971days of cycling, 3437 near misses were reported. For a given time cycling, cyclists who rode mainly for transport (compared with those who rode mainly for recreation), and cyclists with less experience (compared to those with more experience) were more likely to report a near miss; older cyclists (60+ years) were less likely to report a near miss than younger cyclists (25-59 years)...
February 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28230315/achievement-motivation-in-early-schizophrenia-relationship-with-symptoms-cognition-and-functional-outcome
#18
Gagan Fervaha, Hiroyoshi Takeuchi, George Foussias, Margaret K Hahn, Ofer Agid, Gary Remington
BACKGROUND: Individuals with schizophrenia engage in goal-directed activities significantly less often compared to healthy individuals in the community. There is ample evidence documenting the presence of motivational deficits in schizophrenia using observer-based ratings; however, purely self-reported accounts of patients' motivation are less well understood. This study examined subjective accounts of trait achievement motivation among relatively young, clinically stable, early-course outpatients with schizophrenia...
February 23, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28229038/geographic-area-based-rate-as-a-novel-indicator-to-enhance-research-and-precision-intervention-for-more-effective-hiv-aids-control
#19
Xinguang Chen, Kai Wang
Ending the HIV epidemic needs additional methods to better assess the incidence and prevalence of HIV infection. In this study, a new indicator - G-rate was developed for the evaluation of HIV epidemics across regions with regard to geographic area size. Different from the commonly used incidence and prevalence rates that assess the HIV epidemic with reference to population (termed as P rate in this study), G rate measures the number of new infections (incidence) or cases (prevalence) over a unit land area in one year...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28207272/controlling-the-release-of-indomethacin-from-glass-solutions-layered-with-a-rate-controlling-membrane-using-fluid-bed-processing-part-2-the-influence-of-formulation-parameters-on-drug-release
#20
Aswin Dereymaker, Jirka Pelgrims, Frederick Engelen, Peter Adriaensens, Guy Van den Mooter
This study aimed to investigate the pharmaceutical performance of an indomethacin-polyvinylpyrrolidone (PVP) glass solution applied using fluid bed processing as a layer on inert sucrose spheres, and subsequently top-coated with a release rate controlling membrane consisting of either ethyl cellulose or Eudragit RL. The implications of the addition of a pore former (PVP) and the coating medium (ethanol or water) on the diffusion and release behavior were also considered. In addition, the role of a charge interaction between drug and controlled release polymer on the release was investigated...
February 16, 2017: Molecular Pharmaceutics
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