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https://www.readbyqxmd.com/read/28527071/cost-of-medication-overuse-headache-in-italian-patients-at-the-time-point-of-withdrawal-a-retrospective-study-based-on-real-data
#1
Domenico D'Amico, Licia Grazzi, Marcella Curone, Matilde Leonardi, Alberto Raggi
The objective was to assess the cost of Medication Overuse Headache (MOH) at the time-point of withdrawal treatment. We implemented a protocol in which both direct and indirect cost were directly gathered from patients and referred to the previous three months. Direct costs were calculated by medications for acute treatment and prophylaxis, diagnostic procedures, visits, complementary treatments, informal care. Indirect costs were referred to missed workdays and workdays with reduced productivity: we asked patients to refer their salaries and to rate the overall level of performance in days worked with reduced productivity, and we calculated indirect costs on this basis...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#2
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28523289/core-canonical-pathways-involved-in-developing-human-glioblastoma-multiforme-gbm
#3
Somiranjan Ghosh, Sisir Dutta, Gabriel Thorne, Ava Boston, Alexis Barfield, Narendra Banerjee, Rayshawn Walker, Hirendra Nath Banerjee
Glioblastoma multiforme (GBM) is the most common and aggressive type of the primary brain tumors with pathologic hallmarks of necrosis and vascular proliferation. The diagnosis of GBM is currently mostly based on histological examination of brain tumor tissues, after radiological characterization and surgical biopsy. The ability to characterize tumors comprehensively at the molecular level raises the possibility that diagnosis can be made based on molecular profiling with or without histological examination, rather than solely on histological phenotype...
February 2017: Int J Sci Res Sci Eng Technol
https://www.readbyqxmd.com/read/28523252/prevalence-of-sarcopenia-in-the-world-a-systematic-review-and-meta-analysis-of-general-population-studies
#4
REVIEW
Gita Shafiee, Abbasali Keshtkar, Akbar Soltani, Zeinab Ahadi, Bagher Larijani, Ramin Heshmat
BACKGROUND: Sarcopenia, an age-related decline in muscle mass and function, is one of the most important health problems in elderly with a high rate of adverse outcomes. However, several studies have investigated the prevalence of sarcopenia in the world, the results have been inconsistent. The current systematic review and meta- analysis study was conducted to estimate the overall prevalence of sarcopenia in both genders in different regions of the world. METHODS: Electronic databases, including MEDLINE (via PubMed), SCOPUS and Web of Science were searched between January 2009 and December 2016...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28522987/stroke-incidence-in-victoria-australia-emerging-improvements
#5
Benjamin B Clissold, Vijaya Sundararajan, Peter Cameron, John McNeil
BACKGROUND: Evidence of a decline in the incidence of stroke has emerged from population-based studies. These have included retrospective and prospective cohorts. However, in Australia and other countries, government bodies and stroke foundations predict a rise in the prevalence of stroke that is anticipated to increase the burden of stroke across the entire domain of care. This increase in prevalence must be viewed as different from the decline in incidence being observed, a measure of new stroke cases...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28522790/the-influence-of-rifaximin-on-diverticulitis-rate-and-quality-of-life-in-patients-with-diverticulosis
#6
Tomasz Banasiewicz, Wojciech Francuzik, Adam Bobkiewicz, Łukasz Krokowicz, Maciej Borejsza-Wysocki, Jacek Paszkowski, Adam Studniarek, Piotr Krokowicz, Marcin Grochowalski, Marek Szczepkowski, Zbigniew Lorenc
Diverticulosis, its associated symptoms and complications are one of the most common pathologies of the gastrointestinal tract in more economically developed countries. Presence of diverticuli and their clinical consequences can be divided into four categories: 1) diverticulosis, i.e. an asymptomatic presence of diverticuli that are usually found by accident 2) symptomatic uncomplicated diverticulosis 3) diverticulitis (acute uncomplicated diverticulitis) 4) complications of diverticulitis (conditions requiring hospital stay)...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28521841/tnf-inhibitors-appear-to-inhibit-disease-progression-and-improve-outcome-in-takayasu-arteritis-an-observational-population-based-time-trend-study
#7
Birgir Gudbrandsson, Øyvind Molberg, Øyvind Palm
BACKGROUND: Magnetic resonance imaging (MRI) and computed tomography (CT) angiography have now largely replaced interventional angiography in the diagnoses and follow up of Takayasu arteritis (TAK) but data on the effects of this change of imaging method on diagnostic delay and vascular damage, and detailed data on the effect of different treatment regimens on the accumulation of vascular damage are missing. The aim of this study was to assess time trends in diagnostic delay, therapeutic approaches, arterial lesion accrual, persistent disease activity and remission rates in TAK...
May 18, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28521564/estimating-glomerular-filtration-rate-gfr-in-children-the-average-between-a-cystatin-c-and-a-creatinine-based-equation-improves-estimation-of-gfr-in-both-children-and-adults-and-enables-diagnosing-shrunken-pore-syndrome
#8
Felicia Leion, Josefine Hegbrant, Emil den Bakker, Magnus Jonsson, Magnus Abrahamson, Ulf Nyman, Jonas Björk, Veronica Lindström, Anders Larsson, Arend Bökenkamp, Anders Grubb
Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a pivotal role in the diagnosis of Shrunken Pore Syndrome, where low eGFRcystatin C compared to eGFRcreatinine has been associated with higher mortality in adults...
May 19, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28521265/optimizing-the-electrodiagnostic-accuracy-in-guillain-barr%C3%A3-syndrome-subtypes-criteria-sets-and-sparse-linear-discriminant-analysis
#9
Antonino Uncini, Luigi Ippoliti, Nortina Shahrizaila, Yukari Sekiguchi, Satoshi Kuwabara
OBJECTIVE: To optimize the electrodiagnosis of Guillain-Barré syndrome (GBS) subtypes at first study. METHODS: The reference electrodiagnosis was obtained in 53 demyelinating and 45 axonal GBS patients on the basis of two serial studies and results of anti-ganglioside antibodies assay. We retrospectively employed sparse linear discriminant analysis (LDA), two existing electrodiagnostic criteria sets (Hadden et al., 1998; Rajabally et al., 2015) and one we propose that additionally evaluates duration of motor responses, sural sparing pattern and defines reversible conduction failure (RCF) in motor and sensory nerves at second study...
April 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28518169/population-based-impact-of-noninvasive-prenatal-screening-on-screening-and-diagnostic-testing-for-fetal-aneuploidy
#10
Lisa Hui, Briohny Hutchinson, Alice Poulton, Jane Halliday
PurposeTo assess the population-wide impact of noninvasive prenatal screening (NIPS) on combined first-trimester screening (CFTS), early ultrasound (11-13 weeks), and invasive prenatal diagnosis in a state with over 73,000 births per year.MethodsAnalysis of population-based data from 2000 to 2015 including (i) invasive prenatal tests, (ii) CFTS uptake, and (iii) total births. Utilization of early ultrasound was analyzed before and after NIPS (2010-2015).ResultsInvasive testing decreased significantly by 39...
May 18, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28517036/prevalence-of-muscle-weakness-based-on-different-diagnostic-criteria-in-community-dwelling-older-adults-a-comparison-of-grip-strength-dynamometers
#11
Miji Kim, Shoji Shinkai
AIM: The present study compared the performance of the Jamar and Smedley dynamometers for the measurement of grip strength, and the two dynamometers were used to determine the prevalence rate of weakness in a large, community-dwelling, older adult population, based on different diagnostic criteria. METHODS: A total of 467 community-dwelling older adults aged 69-89 years were recruited into the study. Grip strength was measured with two dynamometers; the Jamar hydraulic hand dynamometer was used as the reference device...
May 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28515196/cost-effectiveness-of-therapist-guided-internet-delivered-cognitive-behaviour-therapy-for-paediatric-obsessive-compulsive-disorder-results-from-a-randomised-controlled-trial
#12
Fabian Lenhard, Richard Ssegonja, Erik Andersson, Inna Feldman, Christian Rück, David Mataix-Cols, Eva Serlachius
OBJECTIVES: To evaluate the cost-effectiveness of a therapist-guided internet-delivered cognitive behaviour therapy (ICBT) intervention for adolescents with obsessive-compulsive disorder (OCD) compared with untreated patients on a waitlist. DESIGN: Single-blinded randomised controlled trial. SETTING: A research clinic within the regular child and adolescent mental health service in Stockholm, Sweden. PARTICIPANTS: Sixty-seven adolescents (12-17 years) with a Diagnostic and Statistical Manual of Mental Disorders Fifth Edition diagnosis of OCD...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28514192/diagnostic-and-treatment-patterns-among-children-adolescents-and-young-adults-with-thyroid-cancer-in-ontario-1992-2010
#13
Jason D Pole, Aleksandra M Zuk, Jonathan Daniel Wasserman
BACKGROUND: Thyroid carcinoma (TC) is rare in young children, with a sharp increase in incidence among adolescents and young adults (AYA), between 15 and 29 years of age. The incidence of TC is increasing worldwide. Limited prospective population-based data are available to describe diagnostic and treatment practices in this age group. This study undertook a population-based review of TC among 0 to 29-year-old individuals in Ontario, Canada, utilizing linked administrative data to describe the demographic and care patterns over nearly two decades...
May 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28513567/mental-health-service-utilization-among-black-youth-psychosocial-determinants-in-a-national-sample
#14
Shervin Assari, Cleopatra Howard Caldwell
Racial disparity in mental health service utilization (MHSU) persists, and youths are not an exception to the underutilization of services. Very limited research has been conducted on the determinants of MHSU among Black youth. Using a national sample of American Black youth, the current study investigated the association between demographic factors, socioeconomic status, psychiatric disorders, and self-rated health (SRH) on MHSU. We also tested the heterogeneity of the effects of SRH and psychiatric disorders based on ethnicity, gender, and their intersection...
May 17, 2017: Children
https://www.readbyqxmd.com/read/28512861/rapid-diagnosis-of-sepsis-with-taqman-based-multiplex-real-time-pcr
#15
Chang-Feng Liu, Xin-Ping Shi, Yun Chen, Ye Jin, Bing Zhang
BACKGROUND: The survival rate of septic patients mainly depends on a rapid and reliable diagnosis. A rapid, broad range, specific and sensitive quantitative diagnostic test is the urgent need. Thus, we developed a TaqMan-Based Multiplex real-time PCR assays to identify bloodstream pathogens within a few hours. METHODS: Primers and TaqMan probes were designed to be complementary to conserved regions in the 16S rDNA gene of different kinds of bacteria. To evaluate accurately, sensitively, and specifically, the known bacteria samples (Standard strains, whole blood samples) are determined by TaqMan-Based Multiplex real-time PCR...
May 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28512055/first-plasma-and-tissue-pharmacokinetic-study-of-the-ysnsg-cyclopeptide-a-new-integrin-antagonist-using-microdialysis
#16
F Slimano, Z Djerada, S Bouchene, L Van Gulick, S Brassart-Pasco, S Dukic
The YSNSG peptide is a synthetic peptide targeting αvβ3 integrin. This peptide exhibits promising activity in vitro and in vivo against melanoma. To determine pharmacokinetic parameters and predictive active doses in the central nervous system (CNS) and subcutaneous tissue (SC), we conducted microdialysis coupled with pharmacokinetic modeling and Monte Carlo simulation. After a recovery period of surgical procedures, a microdialysis probe was inserted in the caudate and in subcutaneous tissue. Plasma samples and dialysates collected 5h after YSNSG intravenous administration (10mg/kg) were analyzed by UPLC-MS/MS...
May 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28510985/changing-diagnosis-coding-routines-may-confound-the-results-of-longitudinal-childhood-pneumonia-studies
#17
M Eriksson, A Nilsson, R Bennet
AIM: This Swedish study compared the discharge diagnosis codes used for children up to the age of five hospitalised for acute lower respiratory tract infections before and after the introduction of the pneumococcal conjugate vaccine in 2007. METHODS: The International Classification of Diseases - 10(th) revision codes were used. We compared the discharge diagnosis codes at the Astrid Lindgren Children's Hospital from 1 July 2005 to 30 June 2007 (n=1,127) and 1 July 2011 to 30 June 2013 (n=1,240) in relation to the diagnostic methods used...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28509701/educational-gaps-in-molecular-diagnostics-genomics-and-personalized-medicine-in-dermatopathology-training-a-survey-of-us-dermatopathology-fellowship-program-directors
#18
Kristin Torre, Kristen Russomanno, Tammie Ferringer, Dirk Elston, Michael J Murphy
BACKGROUND: Molecular technologies offer clinicians the tools to provide high-quality, cost-effective patient care. We evaluated education focused on molecular diagnostics, genomics, and personalized medicine in dermatopathology fellowship. DESIGN: A 20-question online survey was emailed to all (n = 53) Accreditation Council for Graduate Medical Education (ACGME)-accredited dermatopathology training programs in the United States. RESULTS: Thirty-one of 53 program directors responded (response rate = 58%)...
May 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28508233/sentinel-lymph-node-mapping-with-isosulfan-blue-or-indocyanine-green-in-colon-cancer-shows-comparable-results-and-identifies-patients-with-decreased-survival-a-prospective-single-center-trial
#19
Benjamin Weixler, Andreas Rickenbacher, Dimitri Aristotle Raptis, Carsten T Viehl, Ulrich Guller, Jessica Rueff, Andreas Zettl, Markus Zuber
BACKGROUND: Sentinel lymph node (SLN) mapping was reported to improve lymph node staging in colon cancer. This study compares isosulfan blue (IB) with indocyanine green (ICG)-based SLN-mapping and assesses the prognostic value of isolated tumor cells (ITC) and micro-metastases in upstaged patients. METHODS: A total of 220 stage I-III colon cancer patients were included in this prospective single-center study. In 170 patients, SLN-mapping was performed in vivo with IB and in 50 patients ex vivo with ICG...
May 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28507989/diagnostic-laparoscopy-as-decision-tool-for-re-recurrent-inguinal-hernia-treatment-following-open-anterior-and-laparo-endoscopic-posterior-repair
#20
Ferdinand Köckerling, Christine Schug-Pass
INTRODUCTION: The guidelines of the international hernia societies recommend posterior repair in laparo-endoscopic technique for recurrent inguinal hernia after open anterior mesh repair and, conversely, open anterior repair for recurrence after laparo-endoscopic primary repair. Even when these guidelines are followed, already 1 year after repair a re-recurrence rate of 1-2% must be expected, with that rate rising further in the subsequent years. Accordingly, increasingly more patients with re-recurrence after anterior and posterior mesh implantation must be treated, which constitutes a problem that to date has been investigated in only very few studies...
2017: Frontiers in Surgery
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