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likelihood ratios test

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https://www.readbyqxmd.com/read/29782466/mucin-expression-in-colorectal-cancer-crc-systematic-review-and-meta-analysis
#1
Yaron Niv, Theodore Rokkas
BACKGROUND: A body of evidence has suggested that mucins play an important role in adhesion, invasion, and cancer metastasis. However, this evidence is scarce and sometimes confusing. OBJECTIVE: We performed a systematic review and meta-analysis of available studies to better define the role of mucins in the behavior of colorectal cancer (CRC). METHODS: Medical literature was searched through November 30, 2017, using suitable keywords. Pooled estimates, that is, odd ratios (ORs), were obtained using fixed or random-effects models, as appropriate...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29781110/initial-derivation-of-diagnostic-clusters-combining-history-elements-and-physical-examination-tests-for-symptomatic-knee-osteoarthritis
#2
Simon Décary, Debbie Feldman, Pierre Frémont, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Michel Fallaha, Bruno Pelletier, Sylvain Belzile, Marie-Pierre Sylvestre, Pascal-André Vendittoli, François Desmeules
INTRODUCTION: The aim of the present study was to assess the validity of clusters combining history elements and physical examination tests to diagnose symptomatic knee osteoarthritis (SOA) compared with other knee disorders. METHODS: This was a prospective diagnostic accuracy study, in which 279 consecutive patients consulting for a knee complaint were assessed. History elements and standardized physical examination tests were obtained independently by a physiotherapist and compared with an expert physician's composite diagnosis, including clinical examination and imaging...
May 21, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29780624/diagnostic-performance-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-the-management-of-solitary-pulmonary-nodule-a-meta-analysis
#3
Duilio Divisi, Mirko Barone, Luca Bertolaccini, Gino Zaccagna, Francesca Gabriele, Roberto Crisci
Background: In the setting of solitary pulmonary nodules (SPNs), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) is considered a useful non-invasive diagnostic tool though false positive (FP) and false negative (FN) results affects accuracy due to different conditions, such as inflammatory diseases or low-uptake neoplasms. Aim of this study is to evaluate overall diagnostic performance of 18 F-FDG-PET/CT for malignant pulmonary nodules...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29779770/normalised-quantitative-polymerase-chain-reaction-for-diagnosis-of-tuberculosis-associated-uveitis
#4
Manas Ranjan Barik, Soveeta Rath, Rohit Modi, Rajkishori Rana, Mamatha M Reddy, Soumyava Basu
Polymerase chain reaction (PCR)-based diagnosis of tuberculosis-associated uveitis (TBU) in TB-endemic countries is challenging due to likelihood of latent mycobacterial infection in both immune and non-immune cells. In this study, we investigated normalised quantitative PCR (nqPCR) in ocular fluids (aqueous/vitreous) for diagnosis of TBU in a TB-endemic population. Mycobacterial copy numbers (mpb64 gene) were normalised to host genome copy numbers (RNAse P RNA component H1 [RPPH1] gene) in TBU (n = 16) and control (n = 13) samples (discovery cohort)...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29778639/sarc-f-for-screening-of-sarcopenia-among-older-adults-a-meta-analysis-of-screening-test-accuracy
#5
Satoshi Ida, Ryutaro Kaneko, Kazuya Murata
OBJECTIVE: To examine the screening ability of SARC-F for older adults using a meta-analysis. DESIGN: Meta-analysis. SETTING AND PARTICIPANTS: The literature review was conducted using MEDLINE, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. Articles written on and after 1960 that included data regarding the sensitivity and specificity of SARC-F's diagnostic criteria for sarcopenia in older adults were searched. MEASURES: The bivariate random effects model was used to calculate the summary estimates of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR)...
May 16, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29778046/evaluation-of-the-microhaplotypes-panel-for-dna-mixture-analyses
#6
Peng Chen, Caiyong Yin, Zheng Li, Yan Pu, Youjia Yu, Peng Zhao, Dexin Chen, Weibo Liang, Lin Zhang, Feng Chen
The identification of a suspect in a DNA mixture typed with the standard short tandem repeat polymorphism (STR) kits has faced challenges. Several improved methods or technologies have been introduced to address this issue. However, some complex situations in the process remain elusive. In the present study, we presented a panel of 26 tiny microhaplotypes, each generating a relatively high (>3.0) effective number of alleles (Ae ) and possessing low (<50 bp) sequence lengths. The average Ae and heterozygosity values among the 9 populations of 26 microhaps were in ranges from 2...
May 12, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29777562/post-operative-stereotactic-radiotherapy-for-the-treatment-of-intracranial-haemangiopericytoma-a-study-of-dose-and-outcome
#7
Rohan Nair, Vanessa Panettieri, Joe H Chang, Michael Dally
INTRODUCTION: This study was performed to assess the relationship between tumour response and radiation dose in equivalent 2 Gy per fraction (EQD2). METHOD: A retrospective cohort analysis of 21 patients with a diagnosis of intracranial haemangiopericytoma between 2000 and 2013 was included in this study. A total of 39 lesions were analysed. The equivalent dose in 2 Gy per fraction was calculated by assigning an alpha-beta ratio of 12 Gy. A paired t-test compared dose (EQD2) and tumour response, and as the outcome was binary, a logistic regression analysis was performed...
May 19, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29776368/comparing-risk-environments-for-hiv-among-people-who-inject-drugs-from-three-cities-in-northern-mexico
#8
Angelica Ospina-Escobar, Carlos Magis-Rodríguez, Fatima Juárez, Dan Werb, Sergio Bautista Arredondo, Rubén Carreón, María Elena Ramos, Steffanie Strathdee
BACKGROUND: A large body of research has investigated the rise of injection drug use and HIV transmission in Tijuana and Ciudad Juarez (CJ). However, little is known about the dynamics of injecting in Hermosillo. This study compares drug-related behaviors and risk environment for HIV of people who inject drugs (PWID) across Tijuana, CJ, and Hermosillo to identify factors that could explain differences in HIV prevalence. METHODS: Data from Tijuana belong to a prospective study (El Cuete IV)...
May 18, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29776330/robust-joint-score-tests-in-the-application-of-dna-methylation-data-analysis
#9
Xuan Li, Yuejiao Fu, Xiaogang Wang, Weiliang Qiu
BACKGROUND: Recently differential variability has been showed to be valuable in evaluating the association of DNA methylation to the risks of complex human diseases. The statistical tests based on both differential methylation level and differential variability can be more powerful than those based only on differential methylation level. Anh and Wang (2013) proposed a joint score test (AW) to simultaneously detect for differential methylation and differential variability. However, AW's method seems to be quite conservative and has not been fully compared with existing joint tests...
May 18, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29775859/facilitating-complex-dna-mixture-interpretation-by-sequencing-highly-polymorphic-haplotypes
#10
Lev Voskoboinik, Uzi Motro, Ariel Darvasi
Interpretation of complex DNA mixtures is an ongoing challenge in the field of forensic genetics. Commonly used STR markers are quite polymorphic, enabling very high statistical association between a single source DNA profile from a crime scene and a matching suspect. STR typing of low order mixtures with two and three contributors also commonly produces high statistical association for a contributor, using current interpretation software. However higher order mixtures, with four contributors or more, are more challenging...
May 2, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29775791/an-imaging-biomarker-for-assessing-hepatic-function-in-patients-with-primary-sclerosing-cholangitis
#11
Jennifer Schulze, Henrike Lenzen, Jan B Hinrichs, Burckhardt Ringe, Michael P Manns, Frank Wacker, Kristina I Ringe
BACKGROUND & AIMS: We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). METHODS: We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium)...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29774966/test-characteristics-of-point-of-care-ultrasound-for-the-diagnosis-of-retinal-detachment-in-the-emergency-department
#12
Daniel J Kim, Mario Francispragasam, Gavin Docherty, Byron Silver, Ross Prager, Donna Lee, David Maberley
Previous studies of point of care ultrasound (POCUS) have reported high sensitivities and specificities for retinal detachment (RD). Our primary objective was to assess the test characteristics of POCUS performed by a large heterogeneous group of emergency physicians (EPs) for the diagnosis of RD. METHODS: This was a prospective diagnostic test assessment of POCUS performed by EPs with varying ultrasound experience on a convenience sample of emergency department (ED) patients presenting with flashes or floaters in one or both eyes...
May 18, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29773076/risk-factors-for-schistosomiasis-in-an-urban-area-in-northern-c%C3%A3-te-d-ivoire
#13
Richard K M'Bra, Brama Kone, Yapi G Yapi, Kigbafori D Silué, Ibrahima Sy, Danielle Vienneau, Nagnin Soro, Guéladio Cissé, Jürg Utzinger
BACKGROUND: Schistosomiasis is a water-based disease transmitted by trematodes belonging to the genus Schistosoma. The aim of this study was to assess the relationship between the prevalence of schistosomiasis and access to water, sanitation and hygiene (WASH) and environmental and socioeconomic factors in the city of Korhogo, northern Côte d'Ivoire. METHODS: A cross-sectional study including 728 randomly selected households was conducted in Korhogo in March 2015...
May 18, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29772968/likelihood-ratios-an-intuitive-tool-for-incorporating-diagnostic-test-results-into-decision-making
#14
Edouard Timsit, Renaud Léguillette, Brad J White, Robert L Larson, Sébastien Buczinski
No abstract text is available yet for this article.
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29772079/detection-of-multiple-perturbations-in-multi-omics-biological-networks
#15
Paula J Griffin, Yuqing Zhang, William Evan Johnson, Eric D Kolaczyk
Cellular mechanism-of-action is of fundamental concern in many biological studies. It is of particular interest for identifying the cause of disease and learning the way in which treatments act against disease. However, pinpointing such mechanisms is difficult, due to the fact that small perturbations to the cell can have wide-ranging downstream effects. Given a snapshot of cellular activity, it can be challenging to tell where a disturbance originated. The presence of an ever-greater variety of high-throughput biological data offers an opportunity to examine cellular behavior from multiple angles, but also presents the statistical challenge of how to effectively analyze data from multiple sources...
May 17, 2018: Biometrics
https://www.readbyqxmd.com/read/29769414/clinical-utility-of-arterial-spin-labeling-for-preoperative-grading-of-glioma-a-diagnostic-meta-analysis
#16
Linchen Li, Xinjun Wang, Min Zhang, Yan Zhang
There were obvious differences in biological behavior and prognosis between low-grade glioma and high-grade glioma, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through November 10, 2017 and used "arterial spin-labeling" OR "ASL perfusion, grading" OR "differentiation, glioma" OR "glial tumor, diagnostic test" as the search terms...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29769153/point-of-care-ultrasound-to-diagnose-appendicitis-in-a-canadian-emergency-department
#17
Sameer Sharif, Steven Skitch, Dean Vlahaki, Andrew Healey
OBJECTIVES: Appendicitis is a common surgical condition that frequently requires diagnostic imaging. Abdominal computed tomography (CT) is the gold standard for diagnosing appendicitis. Ultrasound offers a radiation-free modality; however, its availability outside business hours is limited in many emergency departments (EDs). The purpose of this study is to evaluate the test characteristics of emergency physician-performed point-of-care ultrasound (POCUS) to diagnose appendicitis in a Canadian ED...
May 17, 2018: CJEM
https://www.readbyqxmd.com/read/29766008/diagnostic-utility-of-chest-radiography-in-predicting-long-standing-systemic-arterial-hypertension
#18
Hakan Sahin, Paul Stark
Purpose: To investigate the association between aortic arch width on frontal chest radiography and systemic hypertension. Methods: A total of 200 consecutive patients were included. Relationships between aortic arch width measurement on chest radiography and blood pressure measurement were investigated using Student's t -tests and Fisher's exact tests. Results: Twenty-five patients were normotensive (< 130/90 mmHg), and 175 were hypertensive...
December 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29764502/decreased-macrophage-inflammatory-protein-mip-1%C3%AE-and-mip-1%C3%AE-increase-the-risk-of-developing-nasopharyngeal-carcinoma
#19
Meng-Jie Yang, Jie Guo, Yan-Fang Ye, Sui-Hong Chen, Li-Xia Peng, Chu-Yang Lin, Ting Hu, Shang-Hang Xie, Chuan-Bo Xie, Qi-Hong Huang, Yu-Qiang Lu, Qing Liu, Chao-Nan Qian, Su-Mei Cao
BACKGROUND: The association of circulating inflammation markers with nasopharyngeal carcinoma (NPC) is still largely unclear. This study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern China. METHODS: The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study (150 NPC patients and 150 controls) using multiplex assay platforms...
April 3, 2018: Cancer communications
https://www.readbyqxmd.com/read/29763927/reactive-lymphoid-hyperplasia-or-tubercular-lymphadenitis-can-real-time-pcr-on-fine-needle-aspirates-help-physicians-in-concluding-the-diagnosis
#20
Vivek Gupta, Arvind Bhake
BACKGROUND: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14-100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH...
May 15, 2018: Acta Cytologica
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