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https://www.readbyqxmd.com/read/29332696/a-comparison-of-plastic-cable-ties-based-on-physical-chemical-and-stable-isotopic-measurements
#1
Lisa M Nienaber, Sarah L Cresswell, James F Carter, Tony Peter
Plastic cable ties can be utilised in a range of serious criminal activities and a comparison of cable ties, or fragments, may form part of the physical evidence presented to a Court of law. This research assessed the potential value of evidence based on the analysis of plastic cable ties. Twenty packets of black coloured plastic cable ties (nominally 200mm×4.8mm) were purchased in pack sizes ranging from 25 to 100 individual cable ties (Brisbane, Australia, March 2015). Representative samples from each packet were visually examined, compared and tested to determine their physical dimensions, chemical compositions and stable isotopic compositions (δ2H, δ13C and δ15N)...
January 2018: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29332693/ink-dating-part-ii-interpretation-of-results-in-a-legal-perspective
#2
Agnès Koenig, Céline Weyermann
The development of an ink dating method requires an important investment of resources in order to step from the monitoring of ink ageing on paper to the determination of the actual age of a questioned ink entry. This article aimed at developing and evaluating the potential of three interpretation models to date ink entries in a legal perspective: (1) the threshold model comparing analytical results to tabulated values in order to determine the maximal possible age of an ink entry, (2) the trend tests that focusing on the "ageing status" of an ink entry, and (3) the likelihood ratio calculation comparing the probabilities to observe the results under at least two alternative hypotheses...
January 2018: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29310604/a-modified-tnm-staging-system-for-non-metastatic-colorectal-cancer-based-on-nomogram-analysis-of-seer-database
#3
Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan, Kefeng Ding
BACKGROUND: To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rationality of enhancing T stage's weighting in our previously proposed T-plus staging system. METHODS: Total 115,377 non-metastatic CRC patients from SEER were randomly grouped as training and testing set by ratio 1:1. The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29306919/zero-inflated-conway-maxwell-poisson-distribution-to-analyze-discrete-data
#4
Shin Zhu Sim, Ramesh C Gupta, Seng Huat Ong
In this paper, we study the zero-inflated Conway-Maxwell Poisson (ZICMP) distribution and develop a regression model. Score and likelihood ratio tests are also implemented for testing the inflation/deflation parameter. Simulation studies are carried out to examine the performance of these tests. A data example is presented to illustrate the concepts. In this example, the proposed model is compared to the well-known zero-inflated Poisson (ZIP) and the zero- inflated generalized Poisson (ZIGP) regression models...
January 9, 2018: International Journal of Biostatistics
https://www.readbyqxmd.com/read/29306660/clinical-impact-of-21-gene-recurrence-score-test-within-the-veterans-health-administration-utilization-and-receipt-of-guideline-concordant-care
#5
Leland E Hull, Julie A Lynch, Brygida B Berse, Scott L DuVall, Danielle S Chun, Vicki L Venne, Olga V Efimova, Michael S Icardi, Michael J Kelley
INTRODUCTION: Ensuring guideline-concordant cancer care is a Department of Veterans Affairs (VA) priority, especially as the number of breast cancer patients at VA medical centers (VAMCs) grows. We assessed the utilization and clinical impact of the 21-gene Recurrence Score test, which predicts 10-year risk of breast cancer recurrence and the likelihood of chemotherapy benefit, on veterans newly diagnosed with breast cancer. PATIENTS AND METHODS: We conducted a retrospective cohort study using 2011-2012 VA Central Cancer Registry, chart review, and laboratory test data...
November 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29305453/synovasure-quick-test-is-not-as-accurate-as-the-laboratory-based-%C3%AE-defensin-immunoassay-a-systematic-review-and-meta-analysis
#6
K Suen, M Keeka, R Ailabouni, P Tran
AIMS: α-defensin is a biomarker which has been described as having a high degree of accuracy in the diagnosis of periprosthetic joint infection (PJI). Current meta-analyses are based on the α-defensin laboratory-based immunoassay rather than the quick on-table lateral flow test kit. This study is the first meta-analysis to compare the accuracy of the α-defensin laboratory-based immunoassay and the lateral flow test kit for the diagnosis of PJI. MATERIALS AND METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29301911/neonatal-morbidity-at-term-early-child-development-and-school-performance-a-population-study
#7
Jason P Bentley, Francisco J Schneuer, Samantha J Lain, Andrew J Martin, Adrienne Gordon, Natasha Nassar
OBJECTIVES: Investigate the association between severe neonatal morbidity (SNM) and child development and school performance among term infants. METHODS: The study population included term infants without major congenital conditions born between 2000 and 2007 in New South Wales, Australia, with a linked record of developmental assessment at ages 4 to 6 years in 2009 or 2012 (n = 144 535) or school performance at ages 7 to 9 years from 2009 to 2014 (n = 253 447)...
January 4, 2018: Pediatrics
https://www.readbyqxmd.com/read/29301596/study-of-zero-inflated-regression-models-in-a-large-scale-population-survey-of-sub-health-status-and-its-influencing-factors
#8
Tao Xu, Guang-Jin Zhu, Shao-Mei Han
Objective Sub-health status has progressively gained more attention from both medical professionals and the publics. Treating the number of sub-health symptoms as count data rather than dichotomous data helps to completely and accurately analyze findings in sub-healthy population. This study aims to compare the goodness of fit for count outcome models to identify the optimum model for sub-health study. Methods The sample of the study derived from a large-scale population survey on physiological and psychological constants from 2007 to 2011 in 4 provinces and 2 autonomous regions in China...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29297979/development-of-predictive-signatures-for-treatment-selection-in-precision-medicine-with-survival-outcomes
#9
Yu-Chuan Chen, Un Jung Lee, Chen-An Tsai, James J Chen
For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker-positive and biomarker-negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially...
January 3, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29297603/apc-gene-promoter-aberrant-methylation-in-serum-as-a-biomarker-for-breast-cancer-diagnosis-a-meta-analysis
#10
Xiaojun Qian, Liwei Ruan
BACKGROUND: The aim of this study was to evaluate the clinical efficacy of APC gene promoter methylation in serum as a biomarker for breast cancer (BC) diagnosis. METHODS: Two reviewers systematically searched online resources to identify the publications relevant to APC gene promoter methylation and BC. The data of true positive, false positive, false negative, and true negative were extracted from each included study and pooled for diagnostic sensitivity, specificity, and summary receiver operating characteristic curve...
January 3, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29290785/albumin-to-alkaline-phosphatase-ratio-as-an-independent-prognostic-factor-for-overall-survival-of-advanced-hepatocellular-carcinoma-patients-without-receiving-standard-anti-cancer-therapies
#11
Xiurong Cai, Zhanhong Chen, Jie Chen, Xiaokun Ma, Mingjun Bai, Tiantian Wang, Xiangwei Chen, Donghao Wu, Li Wei, Xing Li, Qu Lin, Jingyun Wen, Danyun Ruan, Zexiao Lin, Min Dong, Xiangyuan Wu
Background Albumin-to-Alkaline Phosphatase Ratio (ALB/ALP ratio, AAPR), a newly developed index of liver function, has been rarely discussed about its prognostic value in malignancies. The current study attempted to evaluate the prognostic prediction of AAPR in advanced HCC. Methods 237 advanced HCC patients who refused any standard anti-cancer therapies were retrospectively analyzed. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Univariate analyses using Kaplan-Meier method and log-rank test, and multivariate analysis using Cox proportional hazards regression model were conducted...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290296/herd-level-risk-factors-associated-with-leptospira-hardjo-infection-in-dairy-herds-in-the-southern-tohoku-japan
#12
Takeshi Miyama, Eiji Watanabe, Yoshimi Ogata, Yoshiro Urushiyama, Naoya Kawahara, Kohei Makita
A cross-sectional study was designed to generate information on the herd level prevalence and the risk factors for Leptospira serovar Hardjo (L. Hardjo) in Yamagata, the southern Tohoku, Japan. Bulk tank milk samples from 109 dairy herds were used to test the herd level sero-prevalence of L. Hardjo using a commercial ELISA kit, which detects both L. interrogans serovar Hardjo and L. borgpetersenii serovar Hardjo. A questionnaire survey was conducted at the sampled farms, and univariable and multivariable analyses were performed...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29290048/screening-and-detection-of-delirium-in-older-ed-patients-performance-of-the-modified-confusion-assessment-method-for-the-emergency-department-mcam-ed-a-two-step-tool
#13
Wolfgang Hasemann, Florian F Grossmann, Rahel Stadler, Roland Bingisser, Dieter Breil, Martina Hafner, Reto W Kressig, Christian H Nickel
Delirium is frequent in older Emergency Department (ED) patients, but detection rates for delirium in the ED are low. To aid in identifying delirium, we developed and implemented a two-step systematic delirium screening and assessment tool in our ED: the modified Confusion Assessment Method for the Emergency Department (mCAM-ED). Components of the mCAM-ED include: (1) screening for inattention, the main feature of delirium, which was performed with the Months Backwards Test (MBT); (2) delirium assessment based on a structured interview with questions from the Mental Status Questionnaire by Kahn et al...
December 30, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29286591/repeated-low-grade-infections-predict-antidepressant-resistant-depression-a-nationwide-population-based-cohort-study
#14
Jia-Shyun Jeng, Cheng-Ta Li, Mu-Hong Chen, Wei-Chen Lin, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Wen-Hang Chang, Yen-Jen Sung
BACKGROUND: The relationship between severe inflammation and clinical depression in the context of major medical illnesses has been addressed, but the relationship between inflammation caused by mild infections and clinical depression is unclear. We aimed to examine whether a history of repeated low-grade infections (RLGI) in medically healthy subjects (MHS) could increase their vulnerability to major depressive disorder (MDD) (ICD-9-CM) and whether RLGI could be associated with higher resistance to antidepressants in those developing MDD...
December 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29282365/genetic-and-clinic-predictors-of-new-onset-diabetes-mellitus-after-transplantation
#15
Núria Saigi-Morgui, Lina Quteineh, Pierre-Yves Bochud, Severine Crettol, Zoltán Kutalik, Nicolas J Mueller, Isabelle Binet, Christian Van Delden, Jürg Steiger, Paul Mohacsi, Jean-Francois Dufour, Paola M Soccal, Manuel Pascual, Chin B Eap
New Onset Diabetes after Transplantation (NODAT) is a frequent complication after solid organ transplantation, with higher incidence during the first year. Several clinical and genetic factors have been described as risk factors of Type 2 Diabetes (T2DM). Additionally, T2DM shares some genetic factors with NODAT. We investigated if three genetic risk scores (w-GRS) and clinical factors were associated with NODAT and how they predicted NODAT development 1 year after transplantation. In both main (n = 725) and replication (n = 156) samples the clinical risk score was significantly associated with NODAT (ORmain: 1...
December 27, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29282073/responsiveness-of-clinical-tests-for-people-with-neck-pain
#16
René Jørgensen, Inge Ris, Carsten Juhl, Deborah Falla, Birgit Juul-Kristensen
BACKGROUND: Responsiveness of a clinical test is highly relevant in order to evaluate the effect of a given intervention. However, the responsiveness of clinical tests for people with neck pain has not been adequately evaluated. The objective of the present study was to examine the responsiveness of four clinical tests which are low cost and easy to perform in a clinical setting, including the craniocervical flexion test, cervical active range of movement, test for the cervical extensors and pressure pain threshold testing...
December 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29279047/financial-capability-and-sociodemographic-factors-among-survivors-of-human-trafficking
#17
David Okech, Stephen Vandiver McGarity, Nathan Hansen, Abigail C Burns, Waylon Howard
Improving the economic well-being of the girls and women is a key to reducing re-trafficking and in providing stability that survivors can use to rebuild their lives. The study looks at how various sociodemographic traits affected the financial capability of n = 144 women and girls who received intervention at a residential care facility in Ghana, West Africa. Three domain of financial capability are assessed in this, i.e., financial risk, financial planning, and financial saving. A scaled likelihood ratio test (chi-square difference test) was used to evaluate the significance of each direct covariate effect(%)...
December 26, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/29278682/weight-of-the-evidence-of-genetic-investigations-of-ancestry-informative-markers
#18
Torben Tvedebrink, Poul Svante Eriksen, Helle Smidt Mogensen, Niels Morling
Ancestry-informative markers (AIMs) are markers that give information about the ancestry of individuals. They are used in forensic genetics for predicting the geographic origin of the investigated individual in crime and identification cases. In the exploration of the genogeographic origin of an AIMs profile, the likelihoods of the AIMs profile in various populations may be calculated. However, there may not be an appropriate reference population in the database. The fact that the likelihood ratio (LR) of one population compared to that of another population is large does not imply that any of the populations is relevant...
December 23, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/29259038/one-hour-glucose-value-as-a-long-term-predictor-of-cardiovascular-morbidity-and-mortality-the-malm%C3%A3-preventive-project
#19
Mette Lundgren Nielsen, Manan Pareek, Margrét Leósdóttir, Karl-Fredrik Eriksson, Peter Nilsson, Michael Hecht Olsen
OBJECTIVE: To examine the predictive capability of a 1-hour versus 2-hour postload glucose value for cardiovascular morbidity and mortality. DESIGN: Prospective, population-based cohort study (Malmö Preventive Project) with subject inclusion 1974-1992. METHODS: 4934 men without known diabetes and cardiovascular disease, who had blood glucose (BG) measured at 0, 20, 40, 60, 90 and 120 min during an OGTT (30g glucose per m2 body surface area), were followed for 27 years...
December 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29250816/bartlett-type-corrections-and-bootstrap-adjustments-of-likelihood-based-inference-methods-for-network-meta-analysis
#20
Hisashi Noma, Kengo Nagashima, Kazushi Maruo, Masahiko Gosho, Toshi A Furukawa
In network meta-analyses that synthesize direct and indirect comparison evidence concerning multiple treatments, multivariate random effects models have been routinely used for addressing between-studies heterogeneities. Although their standard inference methods depend on large sample approximations (eg, restricted maximum likelihood estimation) for the number of trials synthesized, the numbers of trials are often moderate or small. In these situations, standard estimators cannot be expected to behave in accordance with asymptotic theory; in particular, confidence intervals cannot be assumed to exhibit their nominal coverage probabilities (also, the type I error probabilities of the corresponding tests cannot be retained)...
December 18, 2017: Statistics in Medicine
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