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https://www.readbyqxmd.com/read/27764177/development-validation-and-field-testing-of-an-instrument-for-clinical-assessment-of-hiv-associated-neuropathy-and-neuropathic-pain-in-resource-restricted-and-large-population-study-settings
#1
Yohannes W Woldeamanuel, Peter R Kamerman, Demetri G A Veliotes, Tudor J Phillips, David Asboe, Marta Boffito, Andrew S C Rice
HIV-associated sensory peripheral neuropathy (HIV-SN) afflicts approximately 50% of patients on antiretroviral therapy, and is associated with significant neuropathic pain. Simple accurate diagnostic instruments are required for clinical research and daily practice in both high- and low-resource setting. A 4-item clinical tool (CHANT: Clinical HIV-associated Neuropathy Tool) assessing symptoms (pain and numbness) and signs (ankle reflexes and vibration sense) was developed by selecting and combining the most accurate measurands from a deep phenotyping study of HIV positive people (Pain In Neuropathy Study-HIV-PINS)...
2016: PloS One
https://www.readbyqxmd.com/read/27695337/clinical-prediction-rules-for-failed-nonoperative-reduction-of-intussusception
#2
Jiraporn Khorana, Jayanton Patumanond, Nuthapong Ukarapol, Mongkol Laohapensang, Pannee Visrutaratna, Jesda Singhavejsakul
PURPOSE: The nonoperative reduction of intussusception in children can be performed safely if there are no contraindications. Many risk factors associated with failed reduction were defined. The aim of this study was to develop a scoring system for predicting the failure of nonoperative reduction using various determinants. PATIENTS AND METHODS: The data were collected from Chiang Mai University Hospital and Siriraj Hospital from January 2006 to December 2012. Inclusion criteria consisted of patients with intussusception aged 0-15 years with no contraindications for nonoperative reduction...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27406968/prospective-validation-of-the-niaid-faan-criteria%C3%A2-for-emergency-department-diagnosis-of-anaphylaxis
#3
Caitlin E Loprinzi Brauer, Megan S Motosue, James T Li, John B Hagan, M Fernanda Bellolio, Sangil Lee, Ronna L Campbell
BACKGROUND: Anaphylaxis diagnostic criteria were proposed at the Second Symposium on the Definition and Management of Anaphylaxis. These criteria were 97% sensitive and 82% specific when retrospectively validated. OBJECTIVE: To prospectively evaluate the diagnostic accuracy of the National Institute of Allergy and Infectious Diseases/Food Allergy and Anaphylaxis Network (NIAID/FAAN) criteria for diagnosis of anaphylaxis in the emergency department (ED). METHODS: We conducted a prospective observational study of patients seen in our institution's ED from April 2010 to March 2013...
July 9, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27325129/predicting-low-testosterone-in-aging-men-a-systematic-review
#4
Adam C Millar, Adrian N C Lau, George Tomlinson, Alan Kraguljac, David L Simel, Allan S Detsky, Lorraine L Lipscombe
BACKGROUND: Physicians diagnose and treat suspected hypogonadism in older men by extrapolating from the defined clinical entity of hypogonadism found in younger men. We conducted a systematic review to estimate the accuracy of clinical symptoms and signs for predicting low testosterone among aging men. METHODS: We searched the MEDLINE and Embase databases (January 1966 to July 2014) for studies that compared clinical features with a measurement of serum testosterone in men...
September 20, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27306497/spontaneous-subarachnoid-hemorrhage-a-systematic-review-and-meta-analysis-describing-the-diagnostic-accuracy-of-history-physical-examination-imaging-and-lumbar-puncture-with-an-exploration-of-test-thresholds
#5
Christopher R Carpenter, Adnan M Hussain, Michael J Ward, Gregory J Zipfel, Susan Fowler, Jesse M Pines, Marco L A Sivilotti
BACKGROUND: Spontaneous subarachnoid hemorrhage (SAH) is a rare, but serious etiology of headache. The diagnosis of SAH is especially challenging in alert, neurologically intact patients, as missed or delayed diagnosis can be catastrophic. OBJECTIVES: The objective was to perform a diagnostic accuracy systematic review and meta-analysis of history, physical examination, cerebrospinal fluid (CSF) tests, computed tomography (CT), and clinical decision rules for spontaneous SAH...
September 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27140827/alpha%C3%A2-adrenergic-agonists-for-the-management-of-opioid-withdrawal
#6
REVIEW
Linda Gowing, Michael Farrell, Robert Ali, Jason M White
BACKGROUND: Withdrawal is a necessary step prior to drug-free treatment or as the endpoint of long-term substitution treatment. OBJECTIVES: To assess the effectiveness of interventions involving the use of alpha2-adrenergic agonists compared with placebo, reducing doses of methadone, symptomatic medications, or an alpha2-adrenergic agonist regimen different to the experimental intervention, for the management of the acute phase of opioid withdrawal. Outcomes included the withdrawal syndrome experienced, duration of treatment, occurrence of adverse effects, and completion of treatment...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27034920/does-this-patient-have-pheochromocytoma-a-systematic-review-of-clinical-signs-and-symptoms
#7
REVIEW
M Pourian, Davani B Mostafazadeh, A Soltani
CONTEXT: Pheochromocytoma is a rare disease but with high mortality if it is not being diagnosed early. Several biochemical tests with high accuracy have been obtained, but the clinical threshold for request of these tests is not determined clearly. OBJECTIVES: To determine the Likelihood Ratios of clinical symptoms and signs in diagnosing pheochromocytoma. And also meta-analysis of their sensitivity in this disease. DATA SOURCES: MEDLINE was searched for relevant English-language articles dated 1960 to February 2014...
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27023336/identifying-patients-with-bacteremia-in-community-hospital-emergency-rooms-a-retrospective-cohort-study
#8
MULTICENTER STUDY
Taro Takeshima, Yosuke Yamamoto, Yoshinori Noguchi, Nobuyuki Maki, Koichiro Gibo, Yukio Tsugihashi, Asako Doi, Shingo Fukuma, Shin Yamazaki, Eiji Kajii, Shunichi Fukuhara
OBJECTIVES: (1) To develop a clinical prediction rule to identify patients with bacteremia, using only information that is readily available in the emergency room (ER) of community hospitals, and (2) to test the validity of that rule with a separate, independent set of data. DESIGN: Multicenter retrospective cohort study. SETTING: To derive the clinical prediction rule we used data from 3 community hospitals in Japan (derivation). We tested the rule using data from one other community hospital (validation), which was not among the three "derivation" hospitals...
2016: PloS One
https://www.readbyqxmd.com/read/26998444/does-this-patient-have-pheochromocytoma-a-systematic-review-of-clinical-signs-and-symptoms
#9
REVIEW
Akbar Soltani, Mandana Pourian, Babak Mostafazadeh Davani
CONTEXT: Pheochromocytoma is a rare disease but with high mortality if it is not being diagnosed early. Several biochemical tests with high accuracy have been obtained, but the clinical threshold for request of these tests is not determined clearly. OBJECTIVES: To determine the Likelihood Ratios of clinical symptoms and signs in diagnosing pheochromocytoma. And also meta-analysis of their sensitivity in this disease. DATA SOURCES: MEDLINE was searched for relevant English-language articles dated 1960 to February 2014...
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/26875460/-value-of-clinical-signs-in-the-identification-of-mycoplasma-pneumonia-in-community-acquired-pneumonia-in-children
#10
Deyu Zhao, Huizhong Chen, Qianyuan Yang, Li Deng
OBJECTIVE: To evaluate the value of clinical signs in the identification of Mycoplasma pneumonia in children's community acquired pneumonia. METHOD: We searched the Cochrane library, PubMed, CNKI, Wan Fang and VIP databases. According to the inclusion and exclusion criterias, we selected and extracted the related information in the literature. According to the QUADAS evaluation system, we established the quality evaluation standard to evaluate the quality of the included studies and analyzed the difference of the clinical manifestations between Mycoplasmae pneumoniae and non-Mycoplasma pneumoniae in children's community acquired pneumonia...
February 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/26721534/elevated-international-normalized-ratio-values-in-a-patient-receiving-warfarin-and-ceftaroline
#11
Nada M Farhat, Lisa S Hutchinson, Michael Peters
PURPOSE: The case of a patient whose International Normalized Ratio (INR) became elevated due to a probable interaction between ceftaroline and warfarin is reported. SUMMARY: A 65-year-old African-American man developed an INR of >18.0 after completing 12 days of ceftaroline therapy for the treatment of cellulitis while taking warfarin therapy. The patient was on warfarin due to his history of deep vein thrombosis of a lower extremity and pulmonary embolism, and his INR was consistently therapeutic for approximately 2 years before ceftaroline therapy...
January 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/26717031/will-neuroimaging-reveal-a-severe-intracranial-injury-in-this-adult-with-minor-head-trauma-the-rational-clinical-examination-systematic-review
#12
REVIEW
Joshua S Easter, Jason S Haukoos, William P Meehan, Victor Novack, Jonathan A Edlow
IMPORTANCE: Adults with apparently minor head trauma (Glasgow Coma Scale [GCS] scores ≥13 who appear well on examination) may have severe intracranial injuries requiring prompt intervention. Findings from clinical examination can aid in determining which adults with minor trauma have severe intracranial injuries visible on computed tomography (CT). OBJECTIVE: To assess systematically the accuracy of symptoms and signs in adults with minor head trauma in order to identify those with severe intracranial injuries...
December 22, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26587343/lung-ultrasound-in-the-diagnosis-of-pneumonia-in-children-proposal-for-a-new-diagnostic-algorithm
#13
Giulio Iorio, Maria Capasso, Giuseppe De Luca, Salvatore Prisco, Carlo Mancusi, Bruno Laganà, Vincenzo Comune
Background. Despite guideline recommendations, chest radiography (CR) for the diagnosis of community-acquired pneumonia (CAP) in children is commonly used also in mild and/or uncomplicated cases. The aim of this study is to assess the reliability of lung ultrasonography (LUS) as an alternative test in these cases and suggest a new diagnostic algorithm. Methods. We reviewed the medical records of all patients admitted to the pediatric ward from February 1, 2013 to December 31, 2014 with respiratory signs and symptoms...
2015: PeerJ
https://www.readbyqxmd.com/read/26575060/early-administration-of-azithromycin-and-prevention-of-severe-lower-respiratory-tract-illnesses-in-preschool-children-with-a-history-of-such-illnesses-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Leonard B Bacharier, Theresa W Guilbert, David T Mauger, Susan Boehmer, Avraham Beigelman, Anne M Fitzpatrick, Daniel J Jackson, Sachin N Baxi, Mindy Benson, Carey-Ann D Burnham, Michael Cabana, Mario Castro, James F Chmiel, Ronina Covar, Michael Daines, Jonathan M Gaffin, Deborah Ann Gentile, Fernando Holguin, Elliot Israel, H William Kelly, Stephen C Lazarus, Robert F Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, Tod Olin, Stephen P Peters, Wanda Phipatanakul, Jacqueline A Pongracic, Hengameh H Raissy, Kristie Ross, William J Sheehan, Christine Sorkness, Stanley J Szefler, W Gerald Teague, Shannon Thyne, Fernando D Martinez
IMPORTANCE: Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed. OBJECTIVE: To evaluate if early administration of azithromycin, started prior to the onset of severe LRTI symptoms, in preschool children with recurrent severe LRTIs can prevent the progression of these episodes...
November 17, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26541098/a-systematic-review-of-symptoms-for-the-diagnosis-of-ovarian-cancer
#15
REVIEW
Mark H Ebell, MaryBeth B Culp, Taylor J Radke
CONTEXT: Ovarian cancer is common and has significant morbidity and mortality, partly because it is often diagnosed at a late stage. This study sought to determine the accuracy of individual symptoms and combinations of symptoms for the diagnosis of ovarian cancer. EVIDENCE ACQUISITION: MEDLINE was searched, identifying 2,492 abstracts, reviewing 71 articles in full, and ultimately identifying 17 studies published between 2001 and 2014 that met the inclusion criteria...
March 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/26534935/genetic-loci-associated-with-nonobstructive-coronary-artery-disease-in-caucasian-women
#16
Liming Weng, Kent D Taylor, Yii-Der Ida Chen, George Sopko, Sheryl F Kelsey, C Noel Bairey Merz, Carl J Pepine, Virginia M Miller, Jerome I Rotter, Martha Gulati, Mark O Goodarzi, Rhonda M Cooper-DeHoff
Nonobstructive coronary artery disease (CAD) in women is associated with adverse cardiovascular (CV) outcomes; however, information regarding genetic variants that predispose women to nonobstructive CAD is lacking. Women from the Women's Ischemia Syndrome Evaluation (WISE) Study and the St. James Women Take Heart (WTH) Study were genotyped with the Cardio-MetaboChip. WISE enrolled women with symptoms and signs of ischemia referred for coronary angiography; WTH enrolled asymptomatic, community-based women without heart disease...
January 2016: Physiological Genomics
https://www.readbyqxmd.com/read/26511004/does-physiotherapy-diagnosis-of-shoulder-pathology-compare-to-arthroscopic-findings
#17
Mary Elizabeth Magarey, Mark Alan Jones, Chad E Cook, Michael George Hayes
AIMS: To explore the ability of a physiotherapist, using a standardised musculoskeletal physiotherapy assessment protocol, to accurately identify the structures potentially responsible for shoulder symptoms against a standardised arthroscopic shoulder diagnostic assessment, and to determine the physiotherapists' ability to influence post-test diagnostic accuracy. STUDY DESIGN: Consecutive case-based cohort study. SUBJECT SELECTION: All participants were selected by two orthopaedic surgeons for arthroscopic investigation during a 6-month period...
September 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26509726/the-value-of-continuous-st-segment-monitoring-in-the-emergency-department
#18
Leonie Rose Bovino, Marjorie Funk, Michele M Pelter, Mayur M Desai, Vanessa Jefferson, Laura Kierol Andrews, Kenneth Forte
Practice standards for electrocardiographic monitoring recommend continuous ST-segment monitoring (C-STM) in patients presenting to the emergency department (ED) with signs and/or symptoms of acute coronary syndrome (ACS), but few studies have evaluated its use in the ED. We compared time to diagnosis and 30-day adverse events before and after implementation of C-STM. We also evaluated the diagnostic accuracy of C-STM in detecting ischemia and infarction. We prospectively studied 163 adults (preintervention: n = 78; intervention: n = 85) in a single ED and stratified them into low (n = 51), intermediate (n = 100), or high (n = 12) risk using History, ECG, Age, Risk factors, and Troponin (HEART) scores...
October 2015: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/26501851/urinary-biomarkers-for-diagnosis-of-bladder-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Roger Chou, John L Gore, David Buckley, Rongwei Fu, Katie Gustafson, Jessica C Griffin, Sara Grusing, Shelley Selph
BACKGROUND: Urinary biomarkers may be a useful alternative or adjunct to cystoscopy for diagnosis of bladder cancer. PURPOSE: To systematically review the evidence on the accuracy of urinary biomarkers for diagnosis of bladder cancer in adults who have signs or symptoms of the disease or are undergoing surveillance for recurrent disease. DATA SOURCES: Ovid MEDLINE (January 1990 through June 2015), Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and reference lists...
December 15, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26474932/evaluation-of-temporomandibular-joint-disc-displacement-as-a-risk-factor-for-osteoarthrosis
#20
I M Dias, P C de F Cordeiro, K L Devito, M L F Tavares, I C G Leite, R de S Tesch
Temporomandibular joint (TMJ) disc displacement is a clinical sign often found in patients with temporomandibular disorders (TMDs) and associated with TMJ osteoarthrosis. Osteoarthrosis is a degenerative joint disease that may be associated with pain and functional disability. The aim of this study was to evaluate the odds ratio (OR) of joints with disc displacement presenting osteoarthrosis via magnetic resonance imaging (MRI) analysis. In total, 224 TMJ images from patients with signs and symptoms of a TMD were evaluated...
March 2016: International Journal of Oral and Maxillofacial Surgery
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