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https://www.readbyqxmd.com/read/29470650/management-of-knee-dislocation-prior-to-ligament-reconstruction-what-is-the-current-evidence-update-of-a-universal-treatment-algorithm
#1
REVIEW
Alexander Maslaris, Olaf Brinkmann, Matthias Bungartz, Christian Krettek, Michael Jagodzinski, Emmanouil Liodakis
Traumatic knee dislocation is a rare but potentially limb-threatening injury. Thus proper initial diagnosis and treatment up to final ligament reconstruction are extremely important and a precondition to successful outcomes. Reports suggest that evidence-based systematic approaches lead to better results. Because of the complexity of this injury and the inhomogeneity of related literature, there are still various controversies and knowledge gaps regarding decision-making and step-sequencing in the treatment of acute multi-ligament knee injuries and knee dislocations...
February 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29470145/portal-vein-stenosis-preconditioning-of-living-donor-liver-in-swine-early-mechanisms-of-liver-regeneration-and-gain-of-hepatic-functional-mass
#2
Pauline Brige, Geraldine Hery, Anais Palen, Théophile Guilbaud, Christophe Buffat, Anais Moyon, Jean Hardwigsen, Eric Guedj, Benjamin Guillet, Vincent Vidal, Guillaume Gorincour, Sophie Chopinet, Emilie Gregoire
In order to reduce the morbidity and mortality risk for the donor in living donor liver transplantation (LDLT), we previously identified 20% left portal vein (LPV) stenosis as the effective preconditioning to induce cell proliferation in the contralateral lobe without the downstream ipsilateral atrophy. We report, here, the pathways involved in the first hours after the preconditioning and investigate the changes in liver volume and function. Fourteen pigs entered this study. Five of them were used to study the genetic, cellular and molecular mechanisms set up in the early hours after the establishment of our preconditioning...
February 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29467715/limb-remote-ischemic-conditioning-mechanisms-anesthetics-and-the-potential-for-expanding-therapeutic-options
#3
REVIEW
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29466698/erk1-2-mtor-stat3-pathway-mediated-autophagy-alleviates-traumatic-brain-injury-induced-acute-lung-injury
#4
Xiupeng Xu, Tongle Zhi, Zhongyuan Bao, Kuan Jiang, Yinlong Liu, Honglu Chao, Liang Fan, Dong Wang, Zheng Li, Ning Liu, Jing Ji
Acute lung injury (ALI) is one of several complications in patients with traumatic brain injury (TBI). Autophagy is a primary homeostatic process that promotes cell survival under stress. Accumulating evidence implicates autophagy in the pathogenesis of ALI under various conditions. However, the role of autophagy in TBI-induced ALI remains unknown. The aim of this study was to adjust autophagy with pharmacological agents to determine its functional significance in TBI-induced ALI. Rats were preconditioned with autophagy promoter rapamycin or inhibitor 3-methyladenine before they were challenged with TBI...
February 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29464195/danger-changes-the-way-the-mammalian-brain-stores-information-about-innocuous-events-a-study-of-sensory-preconditioning-in-rats
#5
Nathan M Holmes, Mukesh Raipuria, Omar A Qureshi, Simon Killcross, Fred Westbrook
The amygdala is a critical substrate for learning about cues that signal danger. Less is known about its role in processing innocuous or background information. The present study addressed this question using a sensory preconditioning protocol in male rats. In each experiment, rats were exposed to pairings of two innocuous stimuli in stage 1, S2 and S1, and then to pairings of S1 and shock in stage 2. As a consequence of this training, control rats displayed defensive reactions (freezing) when tested with both S2 and S1...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29464109/global-cancer-control-responding-to-the-growing-burden-rising-costs-and-inequalities-in-access
#6
Gerald W Prager, Sofia Braga, Branislav Bystricky, Camilla Qvortrup, Carmen Criscitiello, Ece Esin, Gabe S Sonke, Guillem Argilés Martínez, Jean-Sebastian Frenel, Michalis Karamouzis, Michiel Strijbos, Ozan Yazici, Paolo Bossi, Susana Banerjee, Teresa Troiani, Alexandru Eniu, Fortunato Ciardiello, Josep Tabernero, Christoph C Zielinski, Paolo G Casali, Fatima Cardoso, Jean-Yves Douillard, Svetlana Jezdic, Keith McGregor, Gracemarie Bricalli, Malvika Vyas, André Ilbawi
The cancer burden is rising globally, exerting significant strain on populations and health systems at all income levels. In May 2017, world governments made a commitment to further invest in cancer control as a public health priority, passing the World Health Assembly Resolution 70.12 on cancer prevention and control within an integrated approach. In this manuscript, the 2016 European Society for Medical Oncology Leadership Generation Programme participants propose a strategic framework that is in line with the 2017 WHO Cancer Resolution and consistent with the principle of universal health coverage, which ensures access to optimal cancer care for all people because health is a basic human right...
2018: ESMO Open
https://www.readbyqxmd.com/read/29463759/axogenic-mechanism-enhances-retinal-ganglion-cell-excitability-during-early-progression-in-glaucoma
#7
Michael L Risner, Silvia Pasini, Melissa L Cooper, Wendi S Lambert, David J Calkins
Diseases of the brain involve early axon dysfunction that often precedes outright degeneration. Pruning of dendrites and their synapses represents a potential driver of axonopathy by reducing activity. Optic nerve degeneration in glaucoma, the world's leading cause of irreversible blindness, involves early stress to retinal ganglion cell (RGC) axons from sensitivity to intraocular pressure (IOP). This sensitivity also influences survival of RGC dendrites and excitatory synapses in the retina. Here we tested in individual RGCs identified by type the relationship between dendritic organization and axon signaling to light following modest, short-term elevations in pressure...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29462733/the-effects-of-intermittent-whole-body-hypoxic-preconditioning-on-patients-with-carotid-artery-stenosis
#8
Huajun Tan, Hao Lu, Qian Chen, Xiaoguang Tong, Wei Jiang, Hua Yan
OBJECT: To study the effects of intermittent whole-body hypoxic preconditioning on patients with carotid artery stenosis. METHODS: Fifty patients with carotid artery stenosis were selected and randomly divided into a hypoxic intervention group (HIG) and a control group (CG). Both groups were treated with a hypoxic respiration device for 7 days, the HIG at 18% oxygen and the CG at 21%. Venous blood samples were taken preoperatively and postoperative. The subjects' vital signs were recorded during and after the intervention...
February 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29460384/quantum-rotor-induced-polarization
#9
Benno Meier
Quantum-rotor-induced polarization is closely related to para-hydrogen-induced polarization. In both cases the hyperpolarized spin order derives from rotational interaction, and the Pauli principle by which the symmetry of the rotational ground state dictates the symmetry of the associated nuclear spin state. In quantum-rotor-induced polarization there may be several spin states associated with the rotational ground state, and the hyperpolarization is typically generated by hetero-nuclear cross-relaxation. This review discusses preconditions for quantum-rotor-induced polarization for both the 1-dimensional methyl rotor and the asymmetric rotor H 217O@C60 , i...
February 20, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29460267/hypoxia-preconditioned-human-umbilical-vein-endothelial-cells-protect-against-neurovascular-damage-after-hypoxic-ischemia-in-neonatal-brain
#10
Yi-Chao Lee, Ying-Chao Chang, Chia-Ching Wu, Chao-Ching Huang
Therapy targeting the neurovascular unit may provide effective neuroprotection against neonatal hypoxia-ischemia (HI). We hypothesized that the peripheral injection of hypoxia-preconditioned human umbilical vein endothelial cells (HUVECs) following HI protects against neurovascular damage and provides long-term neuroprotection in a postpartum (P) day-7 rat pup model. Compared with normoxic HUVECs, hypoxic HUVECs showed enhanced migration and angiogenesis in vitro and had augmented migration effects into the brain when administered intraperitoneally in vivo after HI...
February 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29458412/comparison-of-volatile-anesthetic-induced-preconditioning-in-cardiac-and-cerebral-system-molecular-mechanisms-and-clinical-aspects
#11
REVIEW
Shasha Chen, Christopher Lotz, Norbert Roewer, Jens-Albert Broscheit
Volatile anesthetic-induced preconditioning (APC) has shown to have cardiac and cerebral protective properties in both pre-clinical models and clinical trials. Interestingly, accumulating evidences demonstrate that, except from some specific characters, the underlying molecular mechanisms of APC-induced protective effects in myocytes and neurons are very similar; they share several major intracellular signaling pathways, including mediating mitochondrial function, release of inflammatory cytokines and cell apoptosis...
February 20, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29458225/-indication-quality-concepts-and-ethical-implications
#12
Andrea Dörries
BACKGROUND: In recent times - also due to new laws - a good "indication quality" has been called for. The aim of this paper is to contribute to the debate about "indication quality" by looking into the meaning of the term "indication" as well as the meaning of an adequate understanding of quality. METHODS: Initially, a conceptual analysis is made of how indication is an integral part of the therapeutic decision-making process between physician and patient, in which, next to evidence-based elements, also normative elements are included (step 1)...
February 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29457847/preconditioning-with-low-level-laser-irradiation-enhances-the-therapeutic-potential-of-human-adipose-derived-stem-cells-in-a-mouse-model-of-photoaged-skin
#13
Xuan Liao, Sheng-Hong Li, Guang-Hui Xie, Shan Xie, Li-Ling Xiao, Jian-Xing Song, Hong-Wei Liu
The present study was conducted to explore the therapeutic potential of human adipose-derived stem cells (ADSCs) irradiated with a low level laser (LLL). Cultured ADSCs were treated with 650-nm GaAlAs laser irradiation at 2, 4, and 8 J/cm2 . Cell proliferation was quantified by MTT assays, cytokine secretion was determined by enzyme-linked immunosorbent assays, and adipogenic differentiation was examined by oil red O staining. Additionally, the expression profiles of putative ADSC surface markers were analyzed by quantitative real-time PCR...
February 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29454673/remote-ischemic-preconditioning-a-complex-question-with-an-even-more-complex-answer
#14
EDITORIAL
Sarah A Schubert, Irving L Kron
No abstract text is available yet for this article.
February 15, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29454651/effects-of-prophylactic-foscarnet-on-hhv-6-reactivation-and-hhv-6-encephalitis-in-cord-blood-transplant-recipients-a-prospective-multicenter-trial-with-a-historical-control-group
#15
Masao Ogata, Kuniko Takano, Yukiyoshi Moriuchi, Tadakazu Kondo, Toshimitsu Ueki, Nobuaki Nakano, Takehiko Mori, Nobuhiko Uoshima, Koji Nagafuji, Satoshi Yamasaki, Yasuhiko Shibasaki, Rika Sakai, Koji Kato, Ilseung Choi, Yumi Jo, Tetsuya Eto, Shinichi Kako, Kumi Oshima, Takahiro Fukuda
Cord blood transplantation (CBT) is a distinct risk factor for human herpesvirus-6 (HHV-6) reactivation and HHV-6 encephalitis. In a prospective multicenter trial, we investigated the effects of prophylactic foscarnet (90 mg/kg intravenous infusion from day 7 to 27 after CBT) on the occurrence of HHV-6 reactivation, HHV-6 encephalitis, and acute graft-versus-host disease (aGVHD) in CBT recipients. Between 2014 and 2016, a total of 57 patients were included in a foscarnet-prophylaxis group. Outcomes were compared with a historical control group who received CBT between 2010 and 2014 (standard-treatment group, n=63)...
February 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29451211/electroacupuncture-preconditioning-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-suppression-of-dynamin-related-protein-1
#16
Gao-Feng Zhang, Pei Yang, Zeng Yin, Huai-Long Chen, Fu-Guo Ma, Bin Wang, Li-Xin Sun, Yan-Lin Bi, Fei Shi, Ming-Shan Wang
Electroacupuncture preconditioning at acupoint Baihui (GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1 (Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20 (depth 2 mm, intensity 1 mA, frequency 2/15 Hz, for 30 minutes, once a day)...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29449821/intentional-forgetting-in-organizations-the-importance-of-eliminating-retrieval-cues-for-implementing-new-routines
#17
REVIEW
Annette Kluge, Norbert Gronau
To cope with the already large, and ever increasing, amount of information stored in organizational memory, "forgetting," as an important human memory process, might be transferred to the organizational context. Especially in intentionally planned change processes (e.g., change management), forgetting is an important precondition to impede the recall of obsolete routines and adapt to new strategic objectives accompanied by new organizational routines. We first comprehensively review the literature on the need for organizational forgetting and particularly on accidental vs...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29448100/post-ischemic-administration-of-5-methoxyindole-2-carboxylic-acid-at-the-onset-of-reperfusion-affords-neuroprotection-against-stroke-injury-by-preserving-mitochondrial-function-and-attenuating-oxidative-stress
#18
Jinzi Wu, Zhen Jin, Xiaorong Yang, Liang-Jun Yan
We previously reported that 5-methoxyindole-2-carboxylic acid (MICA) could induce preconditioning effect in the ischemic brain of rat. In the present study, we addressed the question of whether MICA could also trigger a postconditioning effect in ischemic stroke. To this end, MICA (100mgkg body weight) was injected intraperitoneally at the onset of 24 h reperfusion following 1 h ischemia in rat brain. Results indicate that stroked animals treated with MICA showed less brain infarction volume than that of vehicle-treated animals...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29447379/acute-exercise-is-not-cardioprotective-and-may-induce-apoptotic-signalling-in-heart-surgery-a-randomized-controlled-trial
#19
Benedikte T Smenes, Fredrik H Bækkerud, Katrine H Slagsvold, Erlend Hassel, Martin Wohlwend, Maria Pinho, Morten Høydal, Ulrik Wisløff, Øivind Rognmo, Alexander Wahba
OBJECTIVES: During open-heart surgery, the myocardium experiences ischaemia-reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia-reperfusion injury in rats, but this has never been investigated in humans. We aimed to investigate whether 1 bout of moderate exercise 24 h prior to surgery protects against mitochondrial and cardiac damage. METHODS: Patients scheduled for elective coronary artery bypass were eligible for this pilot study...
February 13, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29446730/salvaging-the-ischemic-heart-gi-coupled-receptors-in-mast-cells-activate-a-pkc%C3%AF-aldh2-pathway-providing-anti-ras-cardioprotection
#20
Alice Marino, Roberto Levi
BACKGROUND: Excessive norepinephrine (NE) release in the ischemic heart elicits severe and often lethal arrhythmias. Resident cardiac mast cells synthesize and store active renin, which is released upon degranulation, causing the activation of a local cardiac renin-angiotensin system (RAS) responsible for NE release and consequent arrhythmias. Toxic aldehydes, known to be formed by lipid peroxidation in ischemia/reperfusion (I/R), have been shown to degranulate mast cells and activate a local RAS...
February 13, 2018: Current Medicinal Chemistry
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