keyword
MENU ▼
Read by QxMD icon Read
search

Preconditionning

keyword
https://www.readbyqxmd.com/read/28106775/colloidal-fouling-of-nanofiltration-membranes-development-of-a-standard-operating-procedure
#1
Md Abdullaha Al Mamun, Subir Bhattacharjee, David Pernitsky, Mohtada Sadrzadeh
Fouling of nanofiltration (NF) membranes is the most significant obstacle to the development of a sustainable and energy-efficient NF process. Colloidal fouling and performance decline in NF processes is complex due to the combination of cake formation and salt concentration polarization effects, which are influenced by the properties of the colloids and the membrane, the operating conditions of the test, and the solution chemistry. Although numerous studies have been conducted to investigate the influence of these parameters on the performance of the NF process, the importance of membrane preconditioning (e...
January 18, 2017: Membranes
https://www.readbyqxmd.com/read/28102287/crotalus-atrox-venom-preconditioning-increases-plasma-fibrinogen-and-reduces-perioperative-hemorrhage-in-a-rat-model-of-surgical-brain-injury
#2
Cherine H Kim, Devin W McBride, Ronak Raval, Prativa Sherchan, Karen L Hay, Eric C K Gren, Wayne Kelln, Tim Lekic, William K Hayes, Brian S Bull, Richard Applegate, Jiping Tang, John H Zhang
Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding. The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as potential preventive therapy for reducing perioperative hemorrhage in the rodent model of surgical brain injury (SBI). C. atrox venom contains snake venom metalloproteinases that cleave fibrinogen into fibrin split products without inducing clotting...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101913/nasopharyngeal-colonization-with-streptococcus%C3%A2-pneumoniae-triggers-dendritic-cell-dependent-antibody-responses-against-invasive-disease-in-mice
#3
Anne Dommaschk, Nadine Ding, Meritxell Tort Tarres, Lara F Bittersohl, Regina Maus, Jennifer Stolper, Danny Jonigk, Peter Braubach, Torsten Lippmann, Tobias Welte, Ulrich A Maus
Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an important precondition for the development of pneumococcal pneumonia. At the same time, nasopharyngeal colonization with Spn has been shown to mount adaptive immune responses against Spn in mice and humans. Cellular responses of the nasopharyngeal compartment, including the nasal-associated lymphoid tissue (NALT), to pneumococcal colonization and their importance for developing adaptive immune responses are poorly defined. We show that nasopharyngeal colonization with S...
January 19, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28101774/newborn-screening-for-remethylation-disorders-and-vitamin-b12-deficiency-evaluation-of-new-strategies-in-cohorts-from-qatar-and-germany
#4
Gwendolyn Gramer, Ghassan Abdoh, Tawfeg Ben-Omran, Noora Shahbeck, Rehab Ali, Laila Mahmoud, Junmin Fang-Hoffmann, Georg F Hoffmann, Hilal Al Rifai, Jürgen G Okun
BACKGROUND: Newborn screening is a precondition for early diagnosis and succeßsful treatment of remethylation disorders and classical homocystinuria (cystathionine-β-synthase deficiency). Newborn screening for classical homocystinuria using total homocysteine measurement in dried blood spots has been very successfully performed for many years for newborns from Qatar. METHODS: A new optimized newborn screening strategy for remethylation disorders and homocystinuria was developed and evaluated for newborns from Qatar using total homocysteine measurement as first-tier and methionine, methionine-phenylalanine-ratio and propionylcarnitine as second-tiers...
January 19, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28095955/preconditioning-to-reduce-decompression-stress-in-scuba-divers
#5
Peter Germonpré, Costantino Balestra
BACKGROUND: Using ultrasound imaging, vascular gas emboli (VGE) are observed after asymptomatic scuba dives and are considered a key element in the potential development of decompression sickness (DCS). Diving is also accompanied with vascular dysfunction, as measured by flow-mediated dilation (FMD). Previous studies showed significant intersubject variability to VGE for the same diving exposure and demonstrated that VGE can be reduced with even a single pre-dive intervention. Several preconditioning methods have been reported recently, seemingly acting either on VGE quantity or on endothelial inflammatory markers...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28094122/cardiac-remote-ischaemic-preconditioning-mechanistic-and-clinical-considerations
#6
REVIEW
Jerrett K Lau, Gabrielle J Pennings, Andy Yong, Leonard Kritharides
Brief, non-harmful ischaemic insults to an organ remote from the heart, remote ischaemic preconditioning (RIPC), has been proposed to confer protection to the heart against ischaemia-reperfusion injury. While most clinical trials of RIPC during coronary interventions (PCI) suggest benefit, recent large, multicentre trials in coronary artery bypass surgery suggest a lack of efficacy. Mechanistically, RIPC most likely promotes the release of circulating factors which modulate multiple cellular pathways in the heart, promoting cell survival...
December 12, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28094003/recombinant-thrombomodulin-suppresses-tumor-growth-of-pancreatic-cancer-by-blocking-thrombin-induced-par1-and-nf-%C3%AE%C2%BAb-activation
#7
Yoshihiro Shirai, Tadashi Uwagawa, Hiroaki Shiba, Yohta Shimada, Takashi Horiuchi, Nobuhiro Saito, Kenei Furukawa, Toya Ohashi, Katsuhiko Yanaga
BACKGROUND: Thrombomodulin, an anticoagulant that inhibits thrombin-induced growth factor promotion, also has an anti-inflammatory effect. Furthermore, thrombomodulin inhibits nuclear factor-kappa B activation, which plays a crucial role in cancer progression. We assessed the antitumor activity of recombinant thrombomodulin for pancreatic cancer. METHODS: A xenograft orthotopic model was established in mice by implantation of human pancreatic cancer cells. The animals were treated with intraperitoneal injection of recombinant thrombomodulin 5 times a week for 4 weeks...
January 13, 2017: Surgery
https://www.readbyqxmd.com/read/28093764/pre-ischemic-mitochondrial-substrate-constraint-by-inhibition-of-malate-aspartate-shuttle-preserves-mitochondrial-function-after-ischemia-reperfusion
#8
Nichlas Riise Jespersen, Takashi Yokota, Nicolaj Brejnholt Støttrup, Andreas Bergdahl, Kim Bolther Paelestik, Jonas Agerlund Povlsen, Flemming Dela, Hans Erik Bøtker
Mitochondrial dysfunction plays a central role in ischemia-reperfusion (IR) injury. The pre-ischemic administration of aminooxyacetate (AOA), an inhibitor of the malate-aspartate shuttle (MAS), provides cardioprotection against IR injury, but the underlying mechanism remains unknown. We hypothesized that a transient inhibition of the MAS during ischemia and early reperfusion could preserve mitochondrial function at later phase of reperfusion in IR-injured heart to the same extent as ischemic preconditioning (IPC), which is a well-validated cardioprotective strategy against IR injury...
January 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28093487/a-pilot-trial-of-the-combination-of-vemurafenib-with-adoptive-cell-therapy-in-patients-with-metastatic-melanoma
#9
Drew C Deniger, Mei Li M Kwong, Anna Pasetto, Mark E Dudley, John R Wunderlich, Michelle M Langhan, Chyi-Chia Richard Lee, Steven A Rosenberg
PURPOSE: This pilot feasibility clinical trial evaluated the coadministration of vemurafenib, a small-molecule antagonist of BRAF(V600) mutations, and tumor-infiltrating lymphocytes (TIL) for the treatment of metastatic melanoma. EXPERIMENTAL DESIGN: A metastatic tumor was resected for growth of TILs, and patients were treated with vemurafenib for 2 weeks, followed by resection of a second lesion. Patients then received a nonmyeloablative preconditioning regimen, infusion of autologous TILs, and high-dose interleukin-2 administration...
January 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28091727/intrinsic-cardiac-ganglia-and-acetylcholine-are-important-in-the-mechanism-of-ischaemic-preconditioning
#10
J M J Pickard, N Burke, S M Davidson, D M Yellon
This study aimed to investigate the role of the intrinsic cardiac nervous system in the mechanism of classical myocardial ischaemic preconditioning (IPC). Isolated perfused rat hearts were subjected to 35-min regional ischaemia and 60-min reperfusion. IPC was induced as three cycles of 5-min global ischaemia-reperfusion, and provided significant reduction in infarct size (IS/AAR = 14 ± 2% vs control IS/AAR = 48 ± 3%, p < 0.05). Treatment with the ganglionic antagonist, hexamethonium (50 μM), blocked IPC protection (IS/AAR = 37 ± 7%, p < 0...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28079313/postischemic-inflammation-in-acute-stroke
#11
REVIEW
Simone Vidale, Arturo Consoli, Marco Arnaboldi, Domenico Consoli
Cerebral ischemia is caused by arterial occlusion due to a thrombus or an embolus. Such occlusion induces multiple and concomitant pathophysiological processes that involve bioenergetic failure, acidosis, loss of cell homeostasis, excitotoxicity, and disruption of the blood-brain barrier. All of these mechanisms contribute to neuronal death, mainly via apoptosis or necrosis. The immune system is involved in this process in the early phases after brain injury, which contributes to potential enlargement of the infarct size and involves the penumbra area...
January 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28077814/life-threatening-ventricular-arrhythmia-and-brugada-type-st-segment-elevation-associated-with-acute-ischemia-of-the-right-ventricular-outflow-tract
#12
Rena Nakamura, Mitsuhiro Nishizaki, Kiko Lee, Masato Shimizu, Hiroyuki Fujii, Noriyoshi Yamawake, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe
BACKGROUND: Brugada-type ECG (Br-ECG) is occasionally observed during acute myocardial ischemia of the right ventricular outflow tract (RVOT). No studies have explored, however, the association of ventricular tachyarrhythmia and development of Br-ECG due to acute ischemia of the RVOT.Methods and Results:The study included 13 consecutive patients with acute ischemia of the RVOT during coronary catheterization. Patients were divided into 2 groups: those with Br-ECG (group B) and those without (group N)...
January 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28077277/berberine-protects-against-ischemia-reperfusion-injury-after-orthotopic-liver-transplantation-via-activating-sirt1-foxo3%C3%AE-induced-autophagy
#13
Yuanbang Lin, Mingwei Sheng, Yiqi Weng, Rubin Xu, Ning Lu, Hongyin Du, Wenli Yu
The effects and mechanism of berberine (BBR) on hepatic injury after orthotopic liver transplantation (OLT) have not been well characterized. We examined the role of Sirt1/FoxO3α axis in the protective effect of BBR on ischemia/reperfusion injury after OLT. Adult male Wistar rats were randomly allocated into four groups: Sham, OLT, OLT with BBR pretreatment (BBR), OLT with BBR and Sirt1 inhibitor (EX527) pretreatment group (EX527). The liver function and oxidative stress level were measured by biochemical and histopathologic examinations...
January 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28074482/remote-ischaemic-preconditioning-suppresses-endogenous-plasma-nitrite-during-ischaemia-reperfusion-a-randomised-controlled-crossover-pilot-study
#14
Ashok Nair, Sitara Khan, Sami Omar, Xiao-Qing Pei, Karen McNeill, Phil Chowienczyk, Andrew James Webb
AIM: To test the hypothesis that remote ischaemic preconditioning (RIPC) increases circulating endogenous local and systemic plasma [nitrite] during RIPC and ischaemia-reperfusion (IR) as a potential protective mechanism against ischaemia-reperfusion injury (IRI). METHODS: Six healthy male volunteers (mean age 29.5 ± 7.6 years) were randomised in a cross-over study to initially receive either RIPC (4 x 5 min cycles) to the left arm, or no RIPC (Control), both followed by an ischaemia-reperfusion (IR) sequence (20 min cuff inflation to 200 mmHg, 20 min reperfusion) to the right arm...
January 10, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28073832/reperfusion-therapy-with-recombinant-human-relaxin-2-serelaxin-attenuates-myocardial-infarct-size-and-nlrp3-inflammasome-following-ischemia-reperfusion-injury-via-enos-dependent-mechanism
#15
Juan Valle Raleigh, Adolfo G Mauro, Teja Devarakonda, Carlo Marchetti, Jun He, Erica Kim, Scott Filippone, Anindita Das, Stefano Toldo, Antonio Abbate, Fadi N Salloum
AIMS: The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide hormone relaxin following ischemic injury have been studied in the heart. Whether reperfusion therapy with recombinant human relaxin-2, serelaxin, reduces myocardial infarct size and attenuates the subsequent NLRP3 inflammasome activation leading to further loss of functional myocardium following ischemia/reperfusion (I/R) injury is unknown. METHODS AND RESULTS: After baseline echocardiography, adult male wild-type C57BL or eNOS knockout mice underwent myocardial infarction (MI) by coronary artery ligation for 30 min followed by 24 h reperfusion...
January 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28073805/sheet-like-remodeling-of-the-transverse-tubular-system-in-human-heart-failure-impairs-excitation-contraction-coupling-and-functional-recovery-by-mechanical-unloading
#16
Thomas Seidel, Sutip Navankasattusas, Azmi A Ahmad, Nikolaos A Diakos, Weining D Xu, Martin Tristani-Firouzi, Michael Bonios, Iosif Taleb, Dean Y Li, Craig H Selzman, Stavros G Drakos, Frank B Sachse
BACKGROUND: -Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has been demonstrated in subgroups of chronic heart failure (HF) patients. Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here, we investigated remodeling of the t-system in human end-stage HF and its role in cardiac recovery. METHODS: -Left ventricular biopsies were obtained from 5 donors (CTRL) and 26 chronic HF patients undergoing implantation of LVADs...
January 10, 2017: Circulation
https://www.readbyqxmd.com/read/28070865/sphingosine-1-phosphate-pretreatment-amends-hypoxia-induced-metabolic-dysfunction-and-impairment-of-myogenic-potential-in-differentiating-c2c12-myoblasts-by-stimulating-viability-calcium-homeostasis-and-energy-generation
#17
Babita Rahar, Sonam Chawla, Sanjay Pandey, Anant Narayan Bhatt, Shweta Saxena
Sphingosine-1-phosphate (S1P) has a role in transpiration in patho-physiological signaling in skeletal muscles. The present study evaluated the pre-conditioning efficacy of S1P in facilitating differentiation of C2C12 myoblasts under a normoxic/hypoxic cell culture environment. Under normoxia, exogenous S1P significantly promoted C2C12 differentiation as evident from morphometric descriptors and differentiation markers of the mature myotubes, but it could facilitate only partial recovery from hypoxia-induced compromised differentiation...
January 9, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28070711/immune-suppression-during-preclinical-drug-development-mitigates-immunogenicity-mediated-impact-on-therapeutic-exposure
#18
Jonathan Herskovitz, Josiah Ryman, Theingi Thway, Stephanie Lee, Lei Zhou, Narendra Chirmule, Bernd Meibohm, Vibha Jawa
In the clinical setting, anti-drug antibodies (ADA) against biotherapeutics can influence patient safety and interfere with product efficacy. High immunogenicity has been addressed in clinic by concomitant immune suppression, such as co-administration of methotrexate with enzyme replacement therapy (ERT) and combination tacrolimus/sirolimus treatment for prophylaxis against organ transplant rejection. This study investigates the use of such immune suppressants in mitigating ADA responses to a fully human monoclonal antibody (mAb1) in preclinical animal studies...
January 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28068879/electrospun-template-architecture-and-composition-regulate-neutrophil-netosis-in-vitro-and-in-vivo
#19
Allison E Fetz, Indira Neeli, Isaac A Rodriguez, Marko Z Radic, Gary Bowlin
Mounting evidence indicates that neutrophils, first responders to an implanted biomaterial, prime the microenvironment for recruited immune cells by secreting factors and releasing neutrophil extracellular traps (NETs) through NETosis. In this study, we investigated the role of electrospun template architecture and composition in regulating NETosis. Electrospun polydioxanone (PDO), collagen type I (COL), and blended PDO-COL templates (PC) were fabricated with small (0.25-0.35µm) and large (1.0-2.00µm) diameter fibers...
January 9, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28068773/truncated-conjugate-gradient-an-optimal-strategy-for-the-analytical-evaluation-of-the-many-body-polarization-energy-and-forces-in-molecular-simulations
#20
Félix Aviat, Antoine Levitt, Benjamin Stamm, Yvon Maday, Pengyu Ren, Jay W Ponder, Louis Lagardère, Jean-Philip Piquemal
We introduce a new class of methods, denoted as Truncated Conjugate Gradient(TCG), to solve the many-body polarization energy and its associated forces in molecular simulations (i.e. molecular dynamics (MD) and Monte Carlo). The method consists in a fixed number of Conjugate Gradient (CG) iterations. TCG approaches provide a scalable solution to the polarization problem at a user-chosen cost and a corresponding optimal accuracy. The optimality of the CG-method guarantees that the number of the required matrix-vector products are reduced to a minimum compared to other iterative methods...
January 10, 2017: Journal of Chemical Theory and Computation
keyword
keyword
101520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"