keyword
MENU ▼
Read by QxMD icon Read
search

Preconditionning

keyword
https://www.readbyqxmd.com/read/29223124/activation-of-mitochondrial-katp-channels-mediates-neuroprotection-induced-by-chronic-morphine-preconditioning-in-hippocampal-ca-1-neurons-following-cerebral-ischemia
#1
Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
PURPOSE: Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29222774/preparation-of-adult-rat-sensory-neuron-cultures-and-their-application-to-growth-cone-turning-assays
#2
Christine A Webber, Douglas W Zochodne
The directional trajectory of growing peripheral nerve axons in the adult impacts their successful regeneration to denervated target tissues. Misdirected axons in neuromas, injured nerve trunks, or nerves with attempted repair diminish the success of regeneration. The behavior of adult rodent peripheral sensory neurons in vitro, in turn, is helpful in predicting axonal behavior in vivo. Here, we describe the adaptation of embryonic neuron growth cone turning assays, an important technique in developmental neurobiology, to adult rat sensory neurons...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222682/-three-dimensional-analysis-of-nasal-physiology-representation-by-means-of-computational-fluid-dynamics
#3
REVIEW
F Sommer, T K Hoffmann, G Mlynski, M Reichert, A-S Grossi, R Kröger, J Lindemann
The human nose takes primary responsibility for preconditioning inhaled air. Numerous pathologies can affect the physiology of the nose. The beginnings of flow analyzes were carried out with three-dimensional casting models and differently colored liquids. Temperature and humidity could not be taken into account. Today, much more complex analyzes are possible using computational fluid dynamics (CFD), which are based on three-dimensional models generated from computed tomography (CT) or magnetic resonance imaging (MRI) datasets...
December 8, 2017: HNO
https://www.readbyqxmd.com/read/29221866/a-capillary-zone-electrophoresis-method-for-detection-of-apolipoprotein-c-iii-glycoforms-and-other-related-artifactually-modified-species
#4
Coralie Ruel, Marco Morani, Arnaud Bruneel, Christophe Junot, Myriam Taverna, François Fenaille, Thuy Tran
ApolipoproteinC-III (ApoC-III) is a human plasma glycoprotein whose O-glycosylation can be altered as a result of congenital disorders of glycosylation (CDG). ApoC-III exhibits three major glycoforms whose relative quantification is of utmost importance for the diagnosis of CDG patients. Considering the very close structures of these glycoforms and their tendency to adsorb on the capillary, a thorough optimization of capillary electrophoresis (CE) parameters including preconditioning and in-between rinsing procedures was required to efficiently separate all the ApoC-III glycoforms...
December 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29221793/pannexin-1-channel-dysfunction-in-the-medial-prefrontal-cortex-mediates-depressive-like-behaviors-induced-by-chronic-social-defeat-stress-and-administration-of-mefloquine-in-mice
#5
Ming Ni, Jin-Gang He, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu
Mefloquine (MFQ) is widely used for the treatment of malaria clinically. Apart from antimalarial effect, psychiatric side effects such as depression and anxiety of MFQ have been reported. Interestingly, MFQ is also known as a broad-spectrum pannexin-1 (Panx1) inhibitor. Panx1 is a new gap junction channel expressed in the brain which mediates efflux of adenosine triphosphate (ATP). Although exogenous ATP has been known to produce a potential antidepressant-like effect, little is known about the role of Panx1 in pathophysiology of depression, especially the depression induced by administration of MFQ...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29218410/cardioprotective-effect-of-thyroid-hormone-is-mediated-by-at2-receptor-and-involves-nitric-oxide-production-via-akt-activation-in-mice
#6
Ivson Bezerra da Silva, Dayane Aparecida Gomes, Natalia Alenina, Michael Bader, Robson Augusto Dos Santos, Maria Luiza M Barreto-Chaves
Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism responsible for this effect. Hyperthyroidism was induced in male wild-type (WT) and AT2R knockout (KO) mice by administering daily intraperitoneal injections of T3 (7 μg/100 g body weight) for 14 days. The mouse hearts were harvested and perfused with a Krebs-Henseleit solution at a constant flow in a Langendorff set-up...
December 7, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29218282/which-tissue-should-be-removed-in-upper-blepharoplasty-analysis-and-evaluation-of-satisfaction
#7
Ali A Saalabian, Paul Liebmann, Maria Deutinger
BACKGROUND: Due to various options for tissue resection and preoperative markings, many different reports on aesthetics and patient's satisfaction exist. To assess differences among tissue resections and risk factors, we herein analyzed satisfaction levels of patients that underwent upper blepharoplasty. METHODS: A retrospective analysis during the period from January 2006 to June 2013 was conducted by reviewing patient's electronic medical files. All patients underwent medically indicated upper blepharoplasty at our department...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29216630/rapamycin-promotes-the-survival-and-adipogenesis-of-ischemia-challenged-adipose-derived-stem-cells-by-improving-autophagy
#8
Chichi Li, Lechi Ye, Li Yang, Xiaofang Yu, Yucang He, Zhuojie Chen, Liqun Li, Dan Zhang
BACKGROUND/AIMS: Ischemia is one of the main causes of the high rate of absorption of transplanted autologous fat. Autophagy allows cells to survive by providing energy under starvation. Rapamycin has been found to play a role in promoting autophagy. In this study, we investigated whether rapamycin participates in the survival and adipogenesis of ischemia-challenged adipose-derived stem cells (ADSCs) by regulating autophagy. METHODS: Before the cells were exposed to oxygen-glucose deprivation (OGD), a simulated ischemic microenvironment, the level of autophagy was reduced or increased by lentiviral transfection with short hairpin RNA targeting microtubule-associated protein 1-light chain 3 gene (shRNA-LC3) or treatment with rapamycin, respectively...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29213350/immediate-early-response-gene-x-1-iex-1-mediates-ischemic-preconditioning-induced-cardioprotection-in-rats
#9
Ming-Jiang Xu, Yan Cai, Aijuan Qu, John Y-J Shyy, Wenjing Li, Xian Wang
Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine whether IEX-1 exerts protective effects against I/R injury. We found that the IEX-1 mRNA level was increased in the IPC-imposed rat heart. However, it was downregulated in the I/R rat heart, which was prevented by in situ IPC...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29213142/the-attitudes-of-ivf-patients-treated-in-the-czech-republic-towards-informing-children-born-after-gamete-donation
#10
Tatana Rumpikova, Ivana Oborna, Silvie Belaskova, Hana Konecna, David Rumpik
BACKGROUND: In recent decades gamete donation has received growing attention. Data from the Czech National Registry of Assisted Reproduction show that the number of cycles using donated oocytes has been increasing every year. According to Czech law, gamete donation is anonymous. Since 2011, some members of the Czech parliament have repeatedly made requests to revoke the anonymity but anonymity is one of the preconditions for such donation in this country. The aim of this study was to find out how the gamete recipients feel towards informing their child about the circumstances of their conception and their access to the identity of the donor...
December 4, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29212557/preconditioning-of-murine-mesenchymal-stem-cells-synergistically-enhanced-immunomodulation-and-osteogenesis
#11
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B Goodman
BACKGROUND: Mesenchymal stem cells (MSCs) are capable of immunomodulation and tissue regeneration, highlighting their potential translational application for treating inflammatory bone disorders. MSC-mediated immunomodulation is regulated by proinflammatory cytokines and pathogen-associated molecular patterns such as lipopolysaccharide (LPS). Previous studies showed that MSCs exposed to interferon gamma (IFN-γ) and the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) synergistically suppressed T-cell activation...
December 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29210794/effect-of-remote-ischemic-preconditioning-on-outcomes-in-adult-cardiac-surgery-a-systematic-review-and-meta-analysis-of-randomized-controlled-studies
#12
Jianfeng Xie, Xiwen Zhang, Jingyuan Xu, Zhongheng Zhang, Nathan J Klingensmith, Songqiao Liu, Chun Pan, Yi Yang, Haibo Qiu
BACKGROUND: Remote ischemic preconditioning (RIPC) has been demonstrated to prevent organ dysfunction in cardiac surgery patients. However, recent large, prospective, multicenter, randomized controlled trials (RCTs) had controversial results. Thus, a meta-analysis of RCTs was performed to investigate whether RIPC can reduce the incidence of acute myocardial infarction (AMI), acute kidney injury (AKI), and mortality in adult cardiac surgery patients. METHODS: Study data were collected from Medline, Elsevier, Cochrane Central Register of Controlled Trials and Web of Science databases...
November 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29209219/differential-effects-of-inhibitor-combinations-on-lysophosphatidic-acid-mediated-chemokine-secretion-in-unprimed-and-tumor-necrosis-factor-%C3%AE-primed-synovial-fibroblasts
#13
Weili Hui, Chenqi Zhao, Sylvain G Bourgoin
Lysophosphatidic acid (LPA) is a pleiotropic bioactive lysophospholipid involved in inflammatory mediator synthesis. Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. The study was undertaken to investigate how LPA activates MSKs and how signaling crosstalk between TNFα and LPA contributes to the super-production of cytokines/chemokines. RAFLS pretreated or not with TNFα were stimulated with LPA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29208889/why-abortion-is-illegal-comparison-of-legal-and-illegal-abortion-a-critical-review
#14
M E Huq, M J Raihan, H Shirin, S Chowdhury, Y Jahan, A S Chowdhury, M M Rahman
Abortion is the termination of pregnancy that occurs spontaneously or purposely. In the most developed world, abortion is legally allowed for women seeking safe termination of pregnancies. Particularly, when access to legal abortion is restricted, abortion is the resort to unsafe methods. The aim of this review is to necessitate safe abortion and to accentuate the consequences of illegal abortion in case of legal prohibition. We used Pubmed, MedLine and Scopus databases to review previous literatures of safe, unsafe, legal and illegal abortions...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207475/function-of-micrornas-in-the-osteogenic-differentiation-and-therapeutic-application-of-adipose-derived-stem-cells-ascs
#15
REVIEW
Walter M Hodges, Frederick O'Brien, Sadanand Fulzele, Mark W Hamrick
Traumatic wounds with segmental bone defects represent substantial reconstructive challenges. Autologous bone grafting is considered the gold standard for surgical treatment in many cases, but donor site morbidity and associated post-operative complications remain a concern. Advances in regenerative techniques utilizing mesenchymal stem cell populations from bone and adipose tissue have opened the door to improving bone repair in the limbs, spine, and craniofacial skeleton. The widespread availability, ease of extraction, and lack of immunogenicity have made adipose-derived stem cells (ASCs) particularly attractive as a stem cell source for regenerative strategies...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29206066/magnesium-induces-preconditioning-of-the-neonatal-brain-via-profound-mitochondrial-protection
#16
Gabriella Koning, Anna-Lena Leverin, Syam Nair, Leslie Schwendimann, Joakim Ek, Ylva Carlsson, Pierre Gressens, Claire Thornton, Xiaoyang Wang, Carina Mallard, Henrik Hagberg
Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring but the mechanism behind this protection is unclear, limiting its effective, safe clinical implementation. Previous studies suggest that MgSO4 is not neuroprotective if administered during or after the insult, so we hypothesised that MgSO4 induces preconditioning in the immature brain. Therefore, we administered MgSO4 at various time-points before/after unilateral hypoxia-ischemia (HI) in seven-day-old rats...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29205219/experimental-analysis-of-insertion-torques-and-forces-of-threaded-and-press-fit-acetabular-cups-by-means-of-ex-vivo-and-in-vivo-measurements
#17
Danny Vogel, Andreas Rathay, Stephanie Teufel, Martin Ellenrieder, Carmen Zietz, Manuela Sander, Rainer Bader
PURPOSE: In THA a sufficient primary implant stability is the precondition for successful secondary stability. Industrial foams of different densities have been used for primary stability investigations. The aim of this study was to analyse and compare the insertion behaviour of threaded and press-fit cups in vivo and ex vivo using bone substitutes with various densities. METHODS: Two threaded (Bicon Plus®, Trident® TC) and one press-fit cup (Trident PSL®) were inserted by orthopaedic surgeons (S1, S2) into 10, 20 and 31 pcf blocks, using modified surgical instruments allowing measurements of the insertion forces and torques...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29204325/acute-ischemic-preconditioning-does-not-influence-high-intensity-intermittent-exercise-performance
#18
Isabela Coelho Marocolo, Gustavo Ribeiro da Mota, André Monteiro Londe, Stephen D Patterson, Octávio Barbosa Neto, Moacir Marocolo
This study evaluated the acute effect of ischemic preconditioning (IPC) on a high-intensity intermittent exercise performance and physiological indicators in amateur soccer players. Thirteen players (21.5 ± 2 yrs) attended three trials separated by 3-5 days in a counterbalanced randomized cross-over design: IPC (4 × 5-min occlusion 220 mmHg/reperfusion 0 mmHg) in each thigh; SHAM (similar to the IPC protocol but "occlusion" at 20 mmHg) and control (seated during the same time of IPC). After 6-min of each trial (IPC, SHAM or control), the players performed the YoYo Intermittent Endurance Test level 2 (YoYoIE2)...
2017: PeerJ
https://www.readbyqxmd.com/read/29202345/effective-removal-of-bromate-in-nitrate-reducing-anoxic-zones-during-managed-aquifer-recharge-for-drinking-water-treatment-laboratory-scale-simulations
#19
Feifei Wang, Doris van Halem, Lei Ding, Ying Bai, Karin Lekkerkerker-Teunissen, Jan Peter van der Hoek
The removal of bromate (BrO3-) as a by-product of ozonation in subsequent managed aquifer recharge (MAR) systems, specifically in anoxic nitrate (NO3-)-reducing zones, has so far gained little attention. In this study, batch reactors and columns were used to explore the influence of NO3- and increased assimilable organic carbon (AOC) due to ozonation pre-treatment on BrO3- removal in MAR systems. 8 m column experiments were carried out for 10 months to investigate BrO3- behavior in anoxic NO3--reducing zones of MAR systems...
November 27, 2017: Water Research
https://www.readbyqxmd.com/read/29201059/a-look-into-stem-cell-therapy-exploring-the-options-for-treatment-of-ischemic-stroke
#20
REVIEW
Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H Zhang
Neural stem cells (NSCs) offer a potential therapeutic benefit in the recovery from ischemic stroke. Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional recovery and neurogenesis at the site of injury. Recent animal studies have utilized unique subsets of exogenous and endogenous stem cells as well as preconditioning with pharmacologic agents to better understand the best situation for stem cell proliferation, migration, and differentiation...
2017: Stem Cells International
keyword
keyword
101520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"