Mohammed Eslam, Naim Alkhouri, Pietro Vajro, Ulrich Baumann, Ram Weiss, Piotr Socha, Claude Marcus, Way Seah Lee, Deirdre Kelly, Gilda Porta, Mohamed A El-Guindi, Anna Alisi, Jake P Mann, Nezha Mouane, Louise A Baur, Anil Dhawan, Jacob George
The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults...
October 2021: Lancet. Gastroenterology & Hepatology