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Suzanne M Thompson, Marianne J Nieuwenhuijze, Lisa Kane Low, Raymond de Vries
OBJECTIVE: to describe Dutch midwives' attitudes toward, and motivations for, the promotion of physiological childbirth and to identify factors associated with those attitudes and motivations. DESIGN: exploratory, qualitative design using focus groups. SETTING: The Netherlands. PARTICIPANTS: hospital- and community-based midwives. FINDINGS: four themes emerged: physiological birth as a continuum, navigating the settings, woman-centeredness and competence and confidence...
September 28, 2016: Midwifery
(no author information available yet)
1. A sharp rise in safeguarding applications from hospitals has been blamed for more than 75,000 people being deprived of their liberty in England between April 2015 and March 2016. Read more:
October 12, 2016: Nursing Standard
Sarah Röhrig, Susan Schröpfer, Alexander Knoll, Holger Puchta
The stability of repetitive sequences in complex eukaryotic genomes is safeguarded by factors suppressing homologues recombination. Prominent in this is the role of the RTR complex. In plants, it consists of the RecQ helicase RECQ4A, the topoisomerase TOP3α and RMI1. Like mammals, but not yeast, plants harbor an additional complex partner, RMI2. Here, we demonstrate that, in Arabidopsis thaliana, RMI2 is involved in the repair of aberrant replication intermediates in root meristems as well as in intrastrand crosslink repair...
October 2016: PLoS Genetics
(no author information available yet)
No abstract text is available yet for this article.
October 8, 2016: Veterinary Record
Guilherme V T Ribeiro, Alberto L Teixido, Newton P U Barbosa, Fernando A O Silveira
Sampling biases permeate ecological research and result in knowledge gaps that have vital consequences for conservation planning. The consequences of knowledge gaps on species identity and distribution (the Wallacean and Linnean shortfalls, respectively) have become apparent recently, but we know little about the extent that research biases and knowledge gaps on traits that influence species' niches (the Hutchinsonian shortfall) affect conservation policy. To examine whether knowledge of species' traits based on seed ecology is geographically, phylogenetically, and ecologically biased, we retrieved research data on seed germination, seed dormancy, seed dispersal, seed banks, seed predation, and seed removal from a database of 847 papers, 1648 species, and 5322 cases...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
Piyal Aravinna, Namal Priyantha, Amarasooriya Pitawala, Sudharma K Yatigammana
Pesticides applied on agricultural lands reach groundwater by leaching, and move to offsite water bodies by direct runoff, erosion and spray drift. Therefore, an assessment of the mobility of pesticides in water resources is important to safeguard such resources. Mobility of pesticides on agricultural lands of Mahaweli river basin in Sri Lanka has not been reported to date. In this context, the mobility potential of 32 pesticides on surface water and groundwater was assessed by widely used pesticide risk indicators, such as Attenuation Factor (AF) index and the Pesticide Impact Rating Index (PIRI) with some modifications...
October 18, 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
Camilla Lauritzen, Charlotte Reedtz
BACKGROUND: Children who have parents with mental health problems are a vulnerable group. Intervening early to support parents with a mental illness can contribute to improve outcomes for children. Rigging the adult mental health system in such a manner that child responsible personnel are designated in wards is a strategy to systematically address the needs of families. It has since 2010 been mandatory for Norwegian hospitals to appoint such personnel in all hospital wards. The current study aimed to investigate the appointment of child responsible personnel in the adult mental health services in a regional hospital with local clinics...
2016: International Journal of Mental Health Systems
Wolfgang Kuchinke, Christian Krauth, René Bergmann, Töresin Karakoyun, Astrid Woollard, Irene Schluender, Benjamin Braasch, Martin Eckert, Christian Ohmann
BACKGROUND: In an unprecedented rate data in the life sciences is generated and stored in many different databases. An ever increasing part of this data is human health data and therefore falls under data protected by legal regulations. As part of the BioMedBridges project, which created infrastructures that connect more than 10 ESFRI research infrastructures (RI), the legal and ethical prerequisites of data sharing were examined employing a novel and pragmatic approach. METHODS: We employed concepts from computer science to create legal requirement clusters that enable legal interoperability between databases for the areas of data protection, data security, Intellectual Property (IP) and security of biosample data...
July 7, 2016: BMC Medical Informatics and Decision Making
Shedra A Snipes, Sharon P Cooper, Eva M Shipp
OBJECTIVE: This paper describes how perceived discrimination shapes the way Latino farmworkers encounter injuries and seek out treatment. METHODS: After 5 months of ethnographic fieldwork, 89 open-ended, semi-structured interviews were analyzed. NVivo was used to code and qualitatively organize the interviews and field notes. Finally, codes, notes, and co-occurring dynamics were used to iteratively assess the data for major themes. RESULTS: The primary source of perceived discrimination was the "boss" or farm owner...
October 17, 2016: Journal of Agromedicine
Sara Andertun, Åsa Hörnsten, Senada Hajdarevic
AIM: The aim of this study was to describe Norwegian healthcare staffs' experiences of participating in care of patients with Ebola virus disease in Sierra Leone. BACKGROUND: Ebola is one of the most feared viruses known. Ebola virus disease is highly contagious with high mortality. The few qualitative studies made on experiences among healthcare professionals have highlighted problems as lack of protective resources, insufficient personnel and risk of societal stigmatization...
October 16, 2016: Journal of Advanced Nursing
Xiaofeng Zheng, Pengyi Yang, Brad Lackford, Brian D Bennett, Li Wang, Hui Li, Yu Wang, Yiliang Miao, Julie F Foley, David C Fargo, Ying Jin, Carmen J Williams, Raja Jothi, Guang Hu
Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3, a component of the Ccr4-Not deadenylase complex, is required for mouse epiblast maintenance. It is highly expressed in blastocysts and its deletion leads to peri-implantation lethality. The epiblast cells in Cnot3 deletion embryos are quickly lost during diapause and fail to outgrow in culture...
October 8, 2016: Stem Cell Reports
Julio C López-Doval, Cassiana C Montagner, Anjaína Fernandes de Alburquerque, Viviane Moschini-Carlos, Gisela Umbuzeiro, Marcelo Pompêo
Reservoirs located in urban areas suffer specific pressures related to human activities. Their monitoring, management, and protection requirements differ from reservoirs situated in non-urbanized areas. The objectives of this study were: (a) to determine the concentrations of select pesticides and emerging pollutants (EPs) present in an urban reservoir; (b) to describe their possible spatial distributions; and (c) to quantify the risks for aquatic life and safeguard drinking water supplies. For this purpose, the Guarapiranga reservoir was studied as an example of a multi-stressed urban reservoir in a tropical region...
October 13, 2016: Science of the Total Environment
P Kalbe
The reform of occupational insurance medical treatment in 2011 also resulted in many changes for occupational insurance consultants in private practice. The transformation of the physicians participating in treatment status (H-Arzt) to accident insurance consultant status (D-Arzt) has resulted in a significant increase in numbers in outpatient fields, which in some cases leads to increased competition. The tentative flexibilization of the conditions for participation of a D‑Arzt is welcomed but must be broadened to safeguard the future...
October 14, 2016: Der Unfallchirurg
Shakoor Hajat, Ceri Whitmore, Christophe Sarran, Andy Haines, Brian Golding, Harriet Gordon-Brown, Anthony Kessel, Lora E Fleming
BACKGROUND: Improved data linkages between diverse environment and health datasets have the potential to provide new insights into the health impacts of environmental exposures, including complex climate change processes. Initiatives that link and explore big data in the environment and health arenas are now being established. OBJECTIVES: To encourage advances in this nascent field, this article documents the development of a web browser application to facilitate such future research, the challenges encountered to date, and how they were addressed...
October 11, 2016: Science of the Total Environment
Eszter Szilassy, Jess Drinkwater, Marianne Hester, Cath Larkins, Nicky Stanley, William Turner, Gene Feder
We describe the development of an evidence-based training intervention on domestic violence and child safeguarding for general practice teams. We aimed - in the context of a pilot study - to improve knowledge, skills, attitudes and self-efficacy of general practice clinicians caring for families affected by domestic violence. Our evidence sources included: a systematic review of training interventions aiming to improve professional responses to children affected by domestic violence; content mapping of relevant current training in England; qualitative assessment of general practice professionals' responses to domestic violence in families; and a two-stage consensus process with a multi-professional stakeholder group...
October 14, 2016: Health & Social Care in the Community
W David Lohr, V Faye Jones
Children in foster care have exceptional needs due to their histories of abuse, neglect, and increased exposure to violence. The rates of psychiatric symptoms and disorders, such as attention-deficit/hyperactivity disorder, posttraumatic stress disorder, and reactive attachment disorder, are much higher in children in foster care; furthermore, the rate of these children receiving psychotropic medications is 3 times that of children who are not in foster care. Pediatricians, in their role of providing a medical home, play a central role in safeguarding the physical and mental health of these children...
October 1, 2016: Pediatric Annals
Reiko Sanokawa-Akakura, Shin Akakura, Siamak Tabibzadeh
Recent evidence suggests that hydrogen sulfide (H2S) has cytoprotective and anti-aging effects. However, the mechanisms for such properties are not fully understood. Here, we show that the expression of the main H2S producing enzyme, CBS, and production of H2S are coordinately diminished in replicative senescent adult human dermal fibroblasts. The reduced production of H2S falls within the same time-frame that the hallmarks of replicative senescence appear including accumulation of SA-β-Gal, enhanced expression of p16, p21, and RRM2B while the expression of RRM2, hTERT, SIRT1, NAMPT, and NAD/NADH ratio all fall...
2016: PloS One
Gabriela Segerer, Kerstin Hadamek, Matthias Zundler, Agnes Fekete, Annegrit Seifried, Martin J Mueller, Frank Koentgen, Manfred Gessler, Elisabeth Jeanclos, Antje Gohla
Mammalian phosphoglycolate phosphatase (PGP) is thought to target phosphoglycolate, a 2-deoxyribose fragment derived from the repair of oxidative DNA lesions. However, the physiological role of this activity and the biological function of the DNA damage product phosphoglycolate is unknown. We now show that knockin replacement of murine Pgp with its phosphatase-inactive Pgp(D34N) mutant is embryonically lethal due to intrauterine growth arrest and developmental delay in midgestation. PGP inactivation attenuated triosephosphate isomerase activity, increased triglyceride levels at the expense of the cellular phosphatidylcholine content, and inhibited cell proliferation...
October 12, 2016: Scientific Reports
S Bala Bhaskar, M Manjuladevi
Research is a systematic process, which uses scientific methods to generate new knowledge that can be used to solve a query or improve on the existing system. Any research on human subjects is associated with varying degree of risk to the participating individual and it is important to safeguard the welfare and rights of the participants. This review focuses on various steps involved in methodology (in continuation with the previous section) before the data are submitted for publication.
September 2016: Indian Journal of Anaesthesia
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