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https://www.readbyqxmd.com/read/29049074/physiology-and-role-of-intraocular-pressure-in-contemporary-anesthesia
#1
Dermot J Kelly, Sinéad M Farrell
More than 26 million Americans suffer with cataracts, and with 3.6 million cataract extractions performed annually in the United States, it is the most common surgical procedure. The integrity of the delicate structures of the eye that mediate vision is dependent on the intraocular pressure (IOP). Yet, IOP acts to compress the vessels within the globe-akin to a Starling resistor-and is a key component that determines the ocular perfusion pressure, defined as the difference between arterial pressure and IOP...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29043452/spatiotemporal-variability-of-drinking-water-quality-and-the-associated-health-risks-in-southwestern-towns-of-ethiopia
#2
Tadesse Sisay, Abebe Beyene, Esayas Alemayehu
The failure to provide safe drinking water services to all people is the greatest development setback of the twenty-first century including Ethiopia. Potential pollutants from various sources are deteriorating drinking water quality in different seasons, and associated health risks were not clearly known. We determined seasonal and spatial variations of urban drinking water characteristics and associated health risks in Agaro, Jimma, and Metu towns, Southwest Ethiopia. Seventy-two samples were collected during dry and rainy seasons of 2014 and 2015...
October 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29040764/rif1-promotes-a-repressive-chromatin-state-to-safeguard-against-endogenous-retrovirus-activation
#3
Pishun Li, Li Wang, Brian D Bennett, Jiajia Wang, Jialun Li, Yufeng Qin, Motoki Takaku, Paul A Wade, Jiemin Wong, Guang Hu
Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their repression are not fully understood. To systematically study ERV repression, we carried out an RNAi screen in mouse embryonic stem cells (ESCs) and identified a list of novel regulators. Among them, Rif1 displays the strongest effect...
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040397/demystifying-the-july-effect-in-plastic-surgery-a-multi-institutional-study
#4
Jordan T Blough, Sumanas W Jordan, Gildasio S De Oliveira, Michael M Vu, John Y S Kim
Background: The "July Effect" refers to a theoretical increase in complications that may occur with the influx of inexperienced interns and residents at the beginning of each academic year in July. Objectives: We endeavored to determine if a July Effect occurs in plastic surgery. Methods: Plastic surgery procedures were isolated from the National Surgical Quality Improvement Program registry. Cases involving residents were grouped as either having occurred within the first academic quarter (AQ1) or remaining year (AQ2-4)...
September 15, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29039887/taking-inventory-to-safeguard-your-practice
#5
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2017: Journal of the California Dental Association
https://www.readbyqxmd.com/read/29038451/tc-ptp-regulates-the-il-7-transcriptional-response-during-murine-early-t-cell-development
#6
K A Pike, T Hatzihristidis, S Bussières-Marmen, F Robert, N Desai, D Miranda-Saavedra, J Pelletier, M L Tremblay
Cytokines play a critical role in directing the discrete and gradual transcriptional changes that define T cell development. The interleukin-7 receptor (IL-7R), via its activation of the JAK-STAT pathway, promotes gene programs that change dynamically as cells progress through T cell differentiation. The molecular mechanism(s) directing differential gene expression downstream of the IL-7R are not fully elucidated. Here, we have identified T cell protein tyrosine phosphatase (TC-PTP), also known as PTPN2, as a negative regulator of IL-7R-STAT signaling in T cell progenitors, contributing to both the quantitative and qualitative nature of STAT-gene targeting...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29034707/female-genital-mutilation-implications-for-clinical-practice
#7
Inez von Rège, Daniel Campion
Female genital mutilation (FGM) is an established cultural practice in over 30 countries. It has no health benefits, carries a high risk of physical and psychological harm, and is illegal in many countries including the UK. A sensitive approach is required, both in the management of complications and prevention of this practice. This article discusses the prevalence and classification of FGM, and offers practical advice to nurses and midwives involved in general and obstetric care. Legal aspects, including safeguarding responsibilities and the mandatory duty to report FGM in England and Wales, are outlined...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29032858/treaty-to-prohibit-nuclear-weapons-towards-safeguarding-humanity
#8
Andy Haines, Ira Helfand
No abstract text is available yet for this article.
October 9, 2017: Lancet
https://www.readbyqxmd.com/read/29029075/improving-health-systems-performance-in-low-and-middle-income-countries-a-system-dynamics-model-of-the-pay-for-performance-initiative-in-afghanistan
#9
O Alonge, S Lin, T Igusa, D H Peters
System dynamics methods were used to explore effective implementation pathways for improving health systems performance through pay-for-performance (P4P) schemes. A causal loop diagram was developed to delineate primary causal relationships for service delivery within primary health facilities. A quantitative stock-and-flow model was developed next. The stock-and-flow model was then used to simulate the impact of various P4P implementation scenarios on quality and volume of services. Data from the Afghanistan national facility survey in 2012 was used to calibrate the model...
September 23, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028471/water-safety-and-lead-regulation-physicians-community-health-responsibilities
#10
Bruce Jennings, Leslie Lyons Duncan
This article reviews the regulation of lead in drinking water, highlighting its epidemiological, engineering, and ethical aspects with a focus on the Flint water crisis. We first discuss water quality policy and its implementation with a focus on lead contamination of water, primarily from pipe systems between a water treatment facility and a tap. We then discuss physicians' roles and ethical responsibilities regarding safe drinking water using a human rights framework. We argue that physicians can play an important role in safeguarding drinking water in their communities by being vigilant, honoring the community's trust in them, and warning, educating, and empowering patients and broader communities so as to protect tap water safety and public health...
October 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29027513/-sharing-patient-information-with-neighbourhood-social-support-teams-a-legal-perspective
#11
V E T Dörenberg
The beginning of 2015 saw the transition of responsibility for social care, youth care and participation of vulnerable groups in the Netherlands from the government to local authorities. A large majority of municipalities chose to work with neighbourhood social support teams. Their main purpose is to offer integrated care to citizens. Integrated care requires information-sharing between organisations and (healthcare) professionals. Are medical practitioners authorized to share patient information with neighbourhood social support teams? Legal analysis shows that a medical practitioner may play one of the following three roles when sharing information with such teams: the role of referrer, the role of expert or the role of informant...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29027130/quality-issues-identified-during-the-evaluation-of-biosimilars-by-the-european-medicines-agency-s-committee-for-medicinal-products-for-human-use
#12
Mark Cilia, Sol Ruiz, Peter Richardson, Tomas Salmonson, Anthony Serracino-Inglott, Francesca Wirth, John Joseph Borg
The aim of this study was to identify trends in deficiencies raised during the EU evaluation of the quality part of dossiers for marketing authorisation applications of biosimilar medicinal products. All adopted day 120 list of questions on the quality module of 22 marketing authorisation applications for biosimilars submitted to the European Medicines Agency and concluded by the end of October 2015 was analysed. Frequencies of common deficiencies identified were calculated and summarised descriptions included...
October 12, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29022038/23-rd-gordon-arthur-ransome-oration-law-and-medicine-professions-of-honour-service-and-excellence
#13
Sundaresh Menon
Amidst dramatic global change, there is a greater need than ever for principled and committed professionals. The sibling professions of law and medicine, in particular, serve crucial functions in contemporary society. To meet the challenges of the future, members of both professions must appreciate and commit to their shared calling to public service, and ensure that it is not overridden by the profit motive. Three further commitments follow from this: first, to nurture and mentor new entrants to the professions to ensure the continuance of that mission of public service; second, to improve accessibility and affordability through pro bono work and by other means, so that all who need professional assistance can receive it; and, thirdly, to serve with excellence in ethics as well as competence, so as not to betray the trust of the laypersons who rely on professionals to safeguard their interests and welfare...
September 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29021919/safeguarding-the-future-of-independent-academic-clinical-cancer-research-in-europe-for-the-benefit-of-patients
#14
Anastassia Negrouk, Denis Lacombe, Fatima Cardoso, Franck Morin, Eva Carrasco, Joan Maurel, Rudolf Maibach, Enrique Aranda, Richard Marais, Rolf A Stahel
Cancer is a complex disease that is constantly evolving. It is now the most common cause of death in Europe after cardiovascular diseases. There are inequalities among European countries, potentially unsustainable healthcare systems impacting quality of cancer care and increasing number of patients with cancer with rare conditions. Clinical and translational research are the backbone in establishing scientific advances as novel treatments and advancing progress to the benefit of patients. Commercially sponsored clinical trials are responsible for developing new medicines that can treat various disease areas, including cancer...
2017: ESMO Open
https://www.readbyqxmd.com/read/29019723/accidental-hanging-injuries-in-children-recognition-and-management
#15
Siba P Paul, Ruby Paul, Paul A Heaton
Accidental hanging is rare in childhood but is often fatal. Window blind cords pose a particular and unique risk to young children in the UK, accounting for one to two deaths annually. These accidents are frequently associated with non-adherence to the safety instructions provided by the manufacturers. Early discovery of the child and initiation of effective cardiopulmonary resuscitation at the site of the incident are likely to improve the outcome. Prolonged suspension, children who are pulseless at first contact by the emergency paramedic responder, and patients with prolonged periods of remaining in asystole before return of spontaneous circulation after starting cardiopulmonary resuscitation are unlikely to have intact neurological survival...
October 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29018176/in-defence-of-governance-ethics-review-and-social-research
#16
Mark Sheehan, Michael Dunn, Kate Sahan
There is a growing body of literature that has sought to undermine systems of ethical regulation, and governance more generally, within the social sciences. In this paper, we argue that any general claim for a system of research ethics governance in social research depends on clarifying the nature of the stake that society has in research. We show that certain accounts of this stake-protecting researchers' freedoms; ensuring accountability for resources; safeguarding welfare; and supporting democracy-raise relevant ethical considerations that are reasonably contested...
October 10, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29017571/dna-damage-response-and-cancer-therapeutics-through-the-lens-of-the-fanconi-anemia-dna-repair-pathway
#17
REVIEW
Sonali Bhattacharjee, Saikat Nandi
Fanconi Anemia (FA) is a rare, inherited genomic instability disorder, caused by mutations in genes involved in the repair of interstrand DNA crosslinks (ICLs). The FA signaling network contains a unique nuclear protein complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. FA proteins act at different steps of ICL repair in sensing, recognition and processing of DNA lesions...
October 10, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28994715/%C3%AE-amyloid-and-the-pathomechanisms-of-alzheimer-s-disease-a-comprehensive-view
#18
REVIEW
Botond Penke, Ferenc Bogár, Lívia Fülöp
Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis network declines during aging. Different cellular stress conditions result in the up-regulation of the neurotrophic, neuroprotective amyloid precursor protein (APP). Enzymatic processing of APP may result in formation of toxic Aβ aggregates (β-amyloids). Protein folding is the basis of life and death. Intracellular Aβ affects the function of subcellular organelles by disturbing the endoplasmic reticulum-mitochondria cross-talk and causing severe Ca(2+)-dysregulation and lipid dyshomeostasis...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28993303/the-lived-experience-of-being-evaluated-for-organ-donation-focus-groups-with-living-kidney-donors
#19
Camilla S Hanson, Angelique F Ralph, Karine E Manera, John S Gill, John Kanellis, Germaine Wong, Jonathan C Craig, Jeremy R Chapman, Allison Tong
BACKGROUND AND OBJECTIVES: Comprehensive evaluations are required to safeguard voluntarism and minimize harm to living kidney donors. This process is lengthy, invasive, and emotionally challenging, with up to one fifth of potential donors opting out. We aimed to describe donors' experiences of the evaluation process. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted 14 focus groups involving 123 kidney donors who completed donation from three transplant centers (Australia and Canada)...
October 9, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28993289/sirt1-and-parp1-as-epigenome-safeguards-and-micrornas-as-sasp-associated-signals-in-cellular-senescence-and-aging
#20
REVIEW
Seyedhossein Hekmatimoghaddam, Ali Dehghani Firoozabadi, Mohamad Reza Zare-Khormizi, Fatemeh Pourrajab
Cellular senescence (CS) is underlying mechanism of organism aging and is closely interconnected with age-related diseases (ARDs). Thus, any attempt that influences CS, may be undertaken to reverse or inhibit senescence, whereby could prolong healthy life span. Until now, two main proposes are epigenetic and genetic modifications of cell fate. The first one concerns rejuvenation through effective reprogramming in cells undergoing senescence, or derived from very old or progeroid patients, by which is effective in vitro in induced pluripotent stem cells (iPSCs)...
October 6, 2017: Ageing Research Reviews
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