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https://www.readbyqxmd.com/read/29688461/transition-to-a-new-electronic-health-record-and-pediatric-medication-safety-lessons-learned-in-pediatrics-within-a-large-academic-health-system
#1
Kimberly Whalen, Emily Lynch, Iman Moawad, Tanya John, Denise Lozowski, Brian M Cummings
Objective: While the electronic health record (EHR) has become a standard of care, pediatric patients pose a unique set of risks in adult-oriented systems. We describe medication safety and implementation challenges and solutions in the pediatric population of a large academic center transitioning its EHR to Epic. Methods: Examination of the roll-out of a new EHR in a mixed neonatal, pediatric and adult tertiary care center with staggered implementation. We followed the voluntarily reported medication error rate for the neonatal and pediatric subsets and specifically monitored the first 3 months after the roll-out of the new EHR...
April 23, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29681228/driving-in-an-urban-environment-the-stress-response-and-effects-of-exercise
#2
Michael Antoun, Ding Ding, Erika E Bohn-Goldbaum, Scott Michael, Kate M Edwards
Driving may be detrimental to health, with one hypothesis suggesting that driving may elicit an acute stress response and, with repeated exposures, may become a chronic stressor. The present study examined the stress response to driving and the effectiveness of a prior exercise bout in dampening this response. Twenty healthy adults performed three tasks: control, driving and exercise plus driving. Heart rate (HR), heart rate variability (HRV), blood pressure (BP) and cortisol were measured to quantify the acute stress response to each condition...
April 23, 2018: Ergonomics
https://www.readbyqxmd.com/read/29680765/current-and-future-effects-of-global-change-on-a-hotspot-s-freshwater-diversity
#3
Belinda Gallardo, Arthur E Bogan, Sahana Harun, Leonardo Jainih, Manuel Lopes-Lima, Manuel Pizarro, Khairul Adha Rahim, Ronaldo Sousa, Salvatore G P Virdis, Alexandra Zieritz
Deforestation, climate change and invasive species constitute three global threats to biodiversity that act synergistically. However, drivers and rates of loss of freshwater biodiversity now and in the future are poorly understood. Here we focus on the potential impacts of global change on freshwater mussels (Order Unionida) in Sundaland (SE Asia), a vulnerable group facing global declines and recognized indicators of overall freshwater biodiversity. We used an ensemble of distribution models to identify habitats potentially suitable for freshwater mussels and their change under a range of climate, deforestation and invasion scenarios...
April 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679825/technologies-for-the-management-of-msw-incineration-ashes-from-gas-cleaning-new-perspectives-on-recovery-of-secondary-raw-materials-and-circular-economy
#4
REVIEW
Margarida J Quina, Elza Bontempi, Anna Bogush, Stefan Schlumberger, Gisela Weibel, Roberto Braga, Valerio Funari, Jiri Hyks, Erik Rasmussen, Jakob Lederer
Environmental policies in the European Union focus on the prevention of hazardous waste and aim to mitigate its impact on human health and ecosystems. However, progress is promoting a shift in perspective from environmental impacts to resource recovery. Municipal solid waste incineration (MSWI) has been increasing in developed countries, thus the amount of air pollution control residues (APCr) and fly ashes (FA) have followed the same upward trend. APCr from MSWI is classified as hazardous waste in the List of Waste (LoW) and as an absolute entry (19 01 07*), but FA may be classified as a mirror entry (19 0 13*/19 01 14)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677999/sifting-through-chaos-extracting-information-from-unstructured-legal-opinions
#5
Bruno Miguel Oliveira, Rui Vasconcellos Guimarães, Luís Antunes, Pedro Pereira Rodrigues
Abiding to the law is, in some cases, a delicate balance between the rights of different players. Re-using health records is such a case. While the law grants reuse rights to public administration documents, in which health records produced in public health institutions are included, it also grants privacy to personal records. To safeguard a correct usage of data, public hospitals in Portugal employ jurists that are responsible for allowing or withholding access rights to health records. To help decision making, these jurists can consult the legal opinions issued by the national committee on public administration documents usage...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677929/openehr-based-systems-and-the-general-data-protection-regulation-gdpr
#6
Mariana Sousa, Duarte Ferreira, Cátia Santos-Pereira, Gustavo Bacelar, Samuel Frade, Olívia Pestana, Ricardo Cruz-Correia
The concerns about privacy and personal data protection resulted in reforms of the existing legislation in European Union (EU). The General Data Protection Regulation (GDPR) aims to reform the existing measures on the topic of personal data protection of the European Union citizens, with a strong input on the rights and freedoms of people and in the establishment of rules for the processing of personal data. OpenEHR is a standard that embodies many principles of interoperable and secure software for electronic health records...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677267/the-short-lived-epidemic-of-botulism-from-commercially-canned-foods-in-the-united-states-1919-to-1925
#7
Powel Kazanjian
In 1919, three deadly outbreaks of botulism caused by consumption of canned olives packed in California captured national headlines. In all of the outbreaks, which occurred in separate locales, unsuspecting people died after consuming tainted food during a banquet or family meal. The press's sensational portrayal of canned food as hazardous aroused alarm among consumers at a time when commercial canning was becoming more common. Intent on restoring the image of their product as safe and wholesome, canning industry leaders funded a "botulism commission" of scientific experts in 1919 to investigate how to systematically eliminate the threat of botulism that had imperiled their business...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29675415/practical-and-ethical-aspects-of-advance-research-directives-for-research-on-healthy-aging-german-and-israeli-professionals-perspectives
#8
Perla Werner, Silke Schicktanz
Background: Healthy aging is the development and maintenance of optimal cognitive, social and physical well-being, and function in older adults. Preventing or minimizing disease is one of the main ways of achieving healthy aging. Dementia is one of the most prevalent and life-changing diseases of old age. Thus, dementia prevention research is defined as one of the main priorities worldwide. However, conducting research with persons who lack the capacity to give consent is a major ethical issue...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675411/cyberbiosecurity-an-emerging-new-discipline-to-help-safeguard-the-bioeconomy
#9
Randall S Murch, William K So, Wallace G Buchholz, Sanjay Raman, Jean Peccoud
Cyberbiosecurity is being proposed as a formal new enterprise which encompasses cybersecurity, cyber-physical security and biosecurity as applied to biological and biomedical-based systems. In recent years, an array of important meetings and public discussions, commentaries and publications have occurred that highlight numerous vulnerabilities. While necessary first steps, they do not provide a systematized structure for effectively promoting communication, education and training, elucidation and prioritization for analysis, research, development, test and evaluation and implementation of scientific, technological, standards of practice, policy, or even regulatory or legal considerations for protecting the bioeconomy...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29674182/forensic-epigenetic-age-estimation-and-beyond-ethical-and-legal-considerations
#10
Mahsa Shabani, Pascal Borry, Inge Smeers, Bram Bekaert
Forensic geneticists are in a race to develop methods based on DNA methylation for various forensic applications, including age estimation. We argue that using epigenetic biomarkers could reveal a broad range of health and life-style related information, therefore it is necessary to develop adequate safeguards to protect the privacy of the individuals under scrutiny.
April 16, 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29674036/use-of-an-ion-mobility-spectrometer-for-detecting-uranium-compounds
#11
Derek R McLain, Jennifer L Steeb, Nicholas A Smith
The safeguards community currently lacks a method to rapidly determine the chemical form of radioactive and non-radioactive compounds in real time during inspection activities. Chemical speciation identification can provide important information on both the types of materials that are collected during environmental sampling and can inform inspectors as to where to focus efforts during inspections or complementary access visits. Ion Mobility Spectrometry (IMS) is an established field technique for the detection of explosives, narcotics, and other organic compounds...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671357/legalised-non-consensual-sterilisation-eugenics-put-into-practice-before-1945-and-the-aftermath-part-2-europe
#12
Jean-Jacques Amy, Sam Rowlands
This article deals with the nine European nations which legalised non-consensual sterilisation during the interwar years, thus completing the review, the first part of which was published in an earlier issue of this Journal. Like we did for North America, Japan and Mexico, countries concerned are addressed in chronological order, as practices in one of these influenced policies in others, involved later. For each, we assess the continuum of events up to the present time. The Swiss canton of Vaud was the first political entity in Europe to introduce a law on compulsory sterilisation of people with intellectual disability, in 1928...
April 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29670118/global-h3-3-dynamic-deposition-defines-its-bimodal-role-in-cell-fate-transition
#13
Hai-Tong Fang, Chadi A El Farran, Qiao Rui Xing, Li-Feng Zhang, Hu Li, Bing Lim, Yuin-Han Loh
H3.3 is a histone variant, which is deposited on genebodies and regulatory elements, by Hira, marking active transcription. Moreover, H3.3 is deposited on heterochromatin by Atrx/Daxx complex. The exact role of H3.3 in cell fate transition remains elusive. Here, we investigate the dynamic changes in the deposition of the histone variant H3.3 during cellular reprogramming. H3.3 maintains the identities of the parental cells during reprogramming as its removal at early time-point enhances the efficiency of the process...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29666131/doctors-on-the-move-a-european-case-study-on-the-key-characteristics-of-national-recertification-systems
#14
Carolin Sehlbach, Marjan J Govaerts, Sharon Mitchell, Gernot G U Rohde, Frank W J M Smeenk, Erik W Driessen
OBJECTIVES: With increased cross-border movement, ensuring safe and high-quality healthcare has gained primacy. The purpose of recertification is to ensure quality of care through periodically attesting doctors' professional proficiency in their field. Professional migration and facilitated cross-border recognition of qualifications, however, make us question the fitness of national policies for safeguarding patient care and the international accountability of doctors. DESIGN AND SETTING: We performed document analyses and conducted 19 semistructured interviews to identify and describe key characteristics and effective components of 10 different European recertification systems, each representing one case (collective case study)...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665951/statistical-considerations-for-pediatric-multidrug-resistant-tuberculosis-efficacy-trials
#15
S Kim, J A Seddon, A J Garcia-Prats, G Montepiedra
The inclusion of newly licensed or repurposed drugs in regimens to treat children for multidrug-resistant tuberculosis (TB) may lead to treatment that is shorter than traditional regimens and composed only of oral medications. As an all-oral regimen may be more acceptable and have a better safety profile than current regimens, demonstrating non-inferiority may be satisfactory. Demonstrating non-inferior efficacy requires setting a non-inferiority margin and safeguarding study assay sensitivity. Multi-arm, multistage designs may currently not be appropriate in pediatric trials because of the lack of sensitive and specific intermediate outcomes...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665819/examination-of-the-roles-and-capacities-of-duty-bearers-responsible-for-protecting-the-human-rights-to-adequate-food-nutritional-health-and-wellbeing-in-ugandan-children-s-homes
#16
Monica Olafsen, Archangel Byaruhanga Rukooko, Per Ole Iversen, Bård A Andreassen
BACKGROUND: The majority of Ugandan children face vulnerability and malnutrition. As a State Party to international human rights treaties, Uganda has legal obligations of guaranteeing the fundamental rights and the best interest of the nation's children. Despite being protected under international and national law, Uganda is not providing adequate child protection, including safeguarding children's food security. Numerous privately owned and unregulated children's homes face this problem...
April 17, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29665723/a-human-rights-approach-to-advocacy-for-people-with-dementia-a-review-of-current-provision-in-england-and-wales
#17
Jeremy Dixon, Judy Laing, Christine Valentine
In this article, we review current advocacy services for people with dementia in England and Wales (provided, respectively, under the Mental Capacity Act 2005 , the Mental Health Act 1983 /2007 and the Care Act 2014) through the lens of the United Nations Convention on the Rights of Persons with Disabilities (CRPD). We examine what a human rights' approach to advocacy support would entail, and whether current frameworks in England and Wales are adequate for this approach and provide a sufficient safeguard. First, we consider how the human rights of persons with dementia have become increasingly important and the extent to which the CRPD provides an opportunity to bolster safeguards and protection...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29664943/do-non-native-species-contribute-to-biodiversity
#18
Martin A Schlaepfer
The Convention on Biological Diversity (CBD) emphasises the role of biodiversity in delivering benefits essential for all people and, as a result, seeks to safeguard all life-forms. The indices that are used to measure progress towards international conservation and sustainability goals, however, focus solely on the 'native' component of biodiversity. A subset of non-native species can cause undesirable economic, social, or biological effects. But non-native species also contribute to regional biodiversity (species richness and biotic interactions) and ecosystem services...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29660106/safety-effectiveness-and-feasibility-of-outpatient-management-of-children-with-pneumonia-with-chest-indrawing-at-port-moresby-general-hospital-papua-new-guinea
#19
Rose Morre, Kone Sobi, Wendy Pameh, Paulus Ripa, John D Vince, Trevor Duke
Implementing the World Health Organization (WHO) recommendations on home-based management of pneumonia with chest indrawing is challenging in many settings. In Papua New Guinea, 120 children presenting with the WHO definition of pneumonia were screened for danger signs, comorbidities and hypoxaemia using pulse oximetry; 117 were appropriate for home care. We taught mothers about danger signs and when to return, using structured teaching materials and a video. The children were given a single dose of intramuscular benzylpenicillin, then sent home on oral amoxicillin for 5 days, with follow-up at Days 2 and 6...
April 6, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29659597/measuring-movement-into-residential-care-institutions-in-haiti-after-hurricane-matthew-a-pilot-study
#20
Beth L Rubenstein, Matthew MacFarlane, Celina Jensen, Lindsay Stark
BACKGROUND: Governments have an ethical imperative to safeguard children in residential care institutions at all times, including in the aftermath of an emergency. Yet, a lack of accurate data about how the magnitude and characteristics of this population may change due to an emergency impedes leaders' ability to formulate responsive policies and services, mobilize resources and foster accountability. The purpose of this study was therefore to determine the feasibility of evaluating movement of children into residential care following an emergency...
2018: PloS One
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