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https://www.readbyqxmd.com/read/28345869/characterization-of-the-aerosol-based-synthesis-of-uranium-particles-as-a-potential-reference-material-for-micro-analytical-methods
#1
Ronald Middendorp, Martin Dürr, Alexander Knott, Fabien Pointurier, Dario Ferreira Sanchez, Valerie Ann Samson, Daniel Grolimund
A process for production of micrometer-sized particles composed of uranium oxide using aerosol spray pyrolysis is characterized with respect to the various production parameters. The aerosol is generated using a vibrating orifice aerosol generator providing monodisperse droplets, which are oxidized in a subsequent heat treatment. The final particles are characterized with micro analytical methods to determine size, shape, internal morphology, chemical and structural properties in order to assess the suitability of the produced particles as a reference material for micro analytical methods, in particular for mass-spectrometry...
March 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28344376/verification-measurements-of-the-irmm-1027-and-the-iaea-large-sized-dried-lsd-spikes
#2
R Jakopič, Y Aregbe, S Richter, E Zuleger, S Mialle, S D Balsley, U Repinc, J Hiess
In the frame of the accountancy measurements of the fissile materials, reliable determinations of the plutonium and uranium content in spent nuclear fuel are required to comply with international safeguards agreements. Large-sized dried (LSD) spikes of enriched (235)U and (239)Pu for isotope dilution mass spectrometry (IDMS) analysis are routinely applied in reprocessing plants for this purpose. A correct characterisation of these elements is a pre-requirement for achieving high accuracy in IDMS analyses. This paper will present the results of external verification measurements of such LSD spikes performed by the European Commission and the International Atomic Energy Agency...
2017: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/28340764/revisiting-the-fission-track-method-for-the-analysis-of-particles-in-safeguards-environmental-samples
#3
N Dzigal, E Chinea-Cano, S Walsh, A Limbeck
This paper details an improved approach to environmental particle analysis for safeguards by means of a combination of an upgraded version of the so-called fission track method with state-of-the-art microscope and microprobe techniques. Improvements to the fission track method comprise a novel sample assembly, the automation of several of its steps and the extensive use of correlative microscopy. This is followed by an automated isolation of particles-of-interest by means of laser micro-dissection (LMD) and their collection onto a harvester for transfer to other micro-analytical instruments for further analysis...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28333823/committee-opinion-no-695-sterilization-of-women-ethical-issues-and-considerations
#4
(no author information available yet)
Sterilization is the most common method of contraception among married couples, with nearly twice as many couples choosing female partner sterilization over male sterilization. Although sterilization is among the most straightforward surgical procedures an obstetrician-gynecologist performs, it is enormously complex when considered from a historical, sociological, or ethical perspective. Sterilization practices have embodied a problematic tension, in which some women who desired fertility were sterilized without their knowledge or consent, and other women who wanted sterilization to limit their family size lacked access to it...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28333815/committee-opinion-no-695-summary-sterilization-of-women-ethical-issues-and-considerations
#5
(no author information available yet)
Sterilization is the most common method of contraception among married couples, with nearly twice as many couples choosing female partner sterilization over male sterilization. Although sterilization is among the most straightforward surgical procedures an obstetrician-gynecologist performs, it is enormously complex when considered from a historical, sociological, or ethical perspective. Sterilization practices have embodied a problematic tension, in which some women who desired fertility were sterilized without their knowledge or consent, and other women who wanted sterilization to limit their family size lacked access to it...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28333676/basics-of-sterile-compounding-personnel-requirements-for-sterile-compounding
#6
Michael J Akers
The risk of microbial contamination during sterile product preparation would be practically non-existent were people not involved in the preparatory process. This article discusses why people are the main source of microbial contamination and what safeguards need to be present to minimize this source.
July 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28331579/an-ssr-based-approach-incorporating-a-novel-algorithm-for-identification-of-rare-maize-genotypes-facilitates-criteria-for-landrace-conservation-in-mexico
#7
Corina Hayano-Kanashiro, Octavio Martínez de la Vega, M Humberto Reyes-Valdés, José-Luis Pons-Hernández, Fernando Hernández-Godinez, Emigdia Alfaro-Laguna, José Luis Herrera-Ayala, Ma Cristina Vega-Sánchez, José Alfredo Carrera-Valtierra, June Simpson
As maize was domesticated in Mexico around 9,000 years ago, local farmers have selected and maintained seed stocks with particular traits and adapted to local conditions. In the present day, many of these landraces are still cultivated; however, increased urbanization and migration from rural areas implies a risk that this invaluable maize germplasm may be lost. In order to implement an efficient mechanism of conservation in situ, the diversity of these landrace populations must be estimated. Development of a method to select the minimum number of samples that would include the maximum number of alleles and identify germplasm harboring rare combinations of particular alleles will also safeguard the efficient ex-situ conservation of this germplasm...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28331049/achieving-precision-death-with-cell-cycle-inhibitors-that-target-dna-replication-and-repair
#8
Aimee Bence Lin, Samuel C McNeely, Richard P Beckmann
All cancers are characterized by defects in the systems that ensure strict control of the cell cycle in normal tissues. The consequent excess tissue growth can be countered by drugs that halt cell division and, indeed, the majority of chemotherapeutics developed during the last century work by disrupting processes essential for the cell cycle, particularly DNA synthesis, DNA replication, and chromatid segregation. In certain contexts the efficacy of these classes of drugs can be impressive but, because they indiscriminately block the cell cycle of all actively dividing cells, their side effects severely constrain the dose and duration with which they can be administered, allowing both normal and malignant cells to escape complete growth arrest...
March 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28330487/a-qualitative-study-of-participants-views-on-re-consent-in-a-longitudinal-biobank
#9
Mary Dixon-Woods, David Kocman, Liz Brewster, Janet Willars, Graeme Laurie, Carolyn Tarrant
BACKGROUND: Biomedical research increasingly relies on long-term studies involving use and re-use of biological samples and data stored in large repositories or "biobanks" over lengthy periods, often raising questions about whether and when a re-consenting process should be activated. We sought to investigate the views on re-consent of participants in a longitudinal biobank. METHODS: We conducted a qualitative study involving interviews with 24 people who were participating in a longitudinal biobank...
March 23, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28329818/elder-fraud-and-financial-exploitation-application-of-routine-activity-theory
#10
Marguerite DeLiema
Background and Objectives: Elder financial exploitation, committed by individuals in positions of trust, and elder fraud, committed by predatory strangers, are two forms of financial victimization that target vulnerable older adults. This study analyzes differences between fraud and financial exploitation victims and tests routine activity theory as a contextual model for victimization. Routine activity theory predicts that criminal opportunities arise when a motivated offender and suitable target meet in the absence of capable guardians...
March 10, 2017: Gerontologist
https://www.readbyqxmd.com/read/28329687/impact-of-dietary-interventions-on-noncoding-rna-networks-and-mrnas-encoding-chromatin-related-factors
#11
Christopher D Green, Yi Huang, Xiaoyang Dou, Liu Yang, Yong Liu, Jing-Dong J Han
Dietary interventions dramatically affect metabolic disease and lifespan in various aging models. Here, we profiled liver microRNA (miRNA), coding, and long non-coding RNA (lncRNA) expression by high-throughput deep sequencing in mice across multiple energy intake and expenditure interventions. Strikingly, three dietary intervention network design patterns were uncovered: (1) lifespan-extending interventions largely repressed the expression of miRNAs, lncRNAs, and transposable elements; (2) protein-coding mRNAs with expression positively correlated with long lifespan are highly targeted by miRNAs; and (3) miRNA-targeting interactions mainly target chromatin-related functions...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28321134/ismp-medication-error-report-analysis
#12
Michael R Cohen, Judy L Smetzer
These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your news-letters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program...
February 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28320736/arabidopsis-retinoblastoma-related-directly-regulates-dna-damage-responses-through-functions-beyond-cell-cycle-control
#13
Beatrix M Horvath, Hana Kourova, Szilvia Nagy, Edit Nemeth, Zoltan Magyar, Csaba Papdi, Zaki Ahmad, Gabino F Sanchez-Perez, Serena Perilli, Ikram Blilou, Aladár Pettkó-Szandtner, Zsuzsanna Darula, Tamas Meszaros, Pavla Binarova, Laszlo Bogre, Ben Scheres
The rapidly proliferating cells in plant meristems must be protected from genome damage. Here, we show that the regulatory role of the Arabidopsis RETINOBLASTOMA RELATED (RBR) in cell proliferation can be separated from a novel function in safeguarding genome integrity. Upon DNA damage, RBR and its binding partner E2FA are recruited to heterochromatic γH2AX-labelled DNA damage foci in an ATM- and ATR-dependent manner. These γH2AX-labelled DNA lesions are more dispersedly occupied by the conserved repair protein, AtBRCA1, which can also co-localise with RBR foci...
March 20, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28319699/urdaibai-biosphere-reserve-biscay-spain-conservation-against-development
#14
Nekane Castillo-Eguskitza, Alejandro J Rescia, Miren Onaindia
The protected area approach has extended from conserving biodiversity to improving human well-being. However, the relationship between conservation and socioeconomic and cultural development continues to be controversial. This paper combines land use variables with socioeconomic and cultural variables through multivariate ordination analysis and evaluates their evolution in two areas inside and outside a Biosphere Reserve since the approval of the Governance Plan for Use and Management in the Reserve. The results indicate a similar tendency in the two areas, from the abandonment of traditional rural activities and decline in pine plantations to naturalness, urban sprawl and the growth of the tertiary economic sector, welfare indicators and sustainability index...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319057/the-poly-a-tail-blocks-rdr6-from-converting-self-mrnas-into-substrates-for-gene-silencing
#15
Kyungmin Baeg, Hiro-Oki Iwakawa, Yukihide Tomari
It remains unclear how post-transcriptional gene silencing (PTGS) in plants discriminates aberrant RNAs from canonical messenger RNAs (mRNAs). The key step of plant PTGS is the conversion of aberrant RNAs into double-stranded RNAs by RNA-DEPENDENT RNA POLYMERASE6 (RDR6). Here, we show that RDR6 itself selects aberrant poly(A)-less mRNAs over canonical polyadenylated mRNAs as templates at the initiation step of complementary strand synthesis. This mechanism can be viewed as an innate safeguard against 'self-attack' by PTGS...
March 20, 2017: Nature Plants
https://www.readbyqxmd.com/read/28314075/expert-views-on-biological-threat-characterization-for-the-u-s-government-a-delphi-study
#16
Crystal R Watson, Matthew C Watson, Gary Ackerman, Gigi Kwik Gronvall
Biological threat characterization (BTC) involves laboratory research conducted for the purpose of biological defense. BTC research is important for improving biological risk assessment and informing resource prioritization. However, there are also risks involved in BTC work, including potential for escape from the laboratory or the misuse of research results. Using a modified Delphi study to gather opinions from U.S. experts in biosecurity and biodefense, this analysis explores what principles and safeguards can maximize the benefits of BTC research and ensure that it is conducted safely and securely...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28300525/disaster-preparedness-among-health-professionals-and-support-staff-what-is-effective-an-integrative-literature-review
#17
Jeremy R Gowing, Kim N Walker, Shandell L Elmer, Elizabeth A Cummings
Introduction It is important that health professionals and support staff are prepared for disasters to safeguard themselves and the community during disasters. There has been a significantly heightened focus on disasters since the terrorist attacks of September 11, 2001 in New York (USA); however, despite this, it is evident that health professionals and support staff may not be adequately prepared for disasters. Report An integrative literature review was performed based on a keyword search of the major health databases for primary research evaluating preparedness of health professionals and support staff...
March 16, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28298329/new-safeguards-are-urgently-needed-for-people-with-reduced-capacity-report-says
#18
Clare Dyer
No abstract text is available yet for this article.
March 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28295561/effects-of-national-level-forest-management-regimes-on-non-protected-forests-of-the-himalaya
#19
Jodi S Brandt, Teri Allendorf, Volker Radeloff, Jeremy Brooks
Globally, deforestation continues, and while protected areas are effective at protecting forests, the majority of forests are not in protected areas. This raises the question how effective are different management regimes to avoid deforestation in non-protected forests. Our objective was to assess the ability of different national-level forest management regimes to safeguard forests outside of protected areas. We compared 2000-2014 deforestation rates across the temperate forests of five countries in the Himalaya (Bhutan, Nepal, China, India, and Myanmar) of which only 13% are protected...
March 15, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28294943/a-team-of-heterochromatin-factors-collaborates-with-small-rna-pathways-to-combat-repetitive-elements-and-germline-stress
#20
Alicia N McMurchy, Przemyslaw Stempor, Tessa Gaarenstroom, Brian Wysolmerski, Yan Dong, Darya Aussianikava, Alex Appert, Ni Huang, Paulina Kolasinska-Zwierz, Alexandra Sapetschnig, Eric A Miska, Julie Ahringer
Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; however, the roles and interactions of heterochromatin proteins in repeat regulation are poorly understood. Here we show that a diverse set of C. elegans heterochromatin proteins act together with the piRNA and nuclear RNAi pathways to silence repetitive elements and prevent genotoxic stress in the germ line. Mutants in genes encoding HPL-2/HP1, LIN-13, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 also show functionally redundant sterility, increased germline apoptosis, DNA repair defects, and interactions with small RNA pathways...
March 15, 2017: ELife
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