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https://www.readbyqxmd.com/read/28051764/the-use-of-fibrin-sealant-during-non-emergency-surgery-a-systematic-review-of-evidence-of-benefits-and-harms
#1
Steven J Edwards, Fay Crawford, Michelle Helena van Velthoven, Andrea Berardi, George Osei-Assibey, Mariana Bacelar, Fatima Salih, Victoria Wakefield
BACKGROUND: Fibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use. OBJECTIVES: To systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults. DATA SOURCES: Electronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and the Cochrane Central Register of Controlled Trials)] were searched from inception to May 2015...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27988140/use-of-mri-in-the-diagnosis-of-fetal-brain-abnormalities-in-utero-meridian-a-multicentre-prospective-cohort-study
#2
Paul D Griffiths, Michael Bradburn, Michael J Campbell, Cindy L Cooper, Ruth Graham, Deborah Jarvis, Mark D Kilby, Gerald Mason, Cara Mooney, Stephen C Robson, Allan Wailoo
BACKGROUND: In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. METHODS: We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study...
December 14, 2016: Lancet
https://www.readbyqxmd.com/read/27968892/hiv-and-syphilis-among-men-who-have-sex-with-men-and-transgender-individuals-in-china-a-scoping-review
#3
Songyuan Tang, Weiming Tang, Kathrine Meyers, Polin Chan, Zhongdan Chen, Joseph D Tucker
BACKGROUND: HIV and syphilis epidemics in men who have sex with men (MSM) continue to grow in China, despite considerable government attention. We did a literature review to synthesise key features of the HIV and syphilis epidemics and responses among MSM and transgender individuals in China. Our goal was to inform evidence-based recommendations for policy makers and program managers. METHODS: We searched Medline, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang using the terms "MSM", "transgender", "meta-analysis", "review", and "China" for articles published in the last six years...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968891/crowdsourcing-health-communication-about-condom-use-in-men-who-have-sex-with-men-in-china-a-randomised-controlled-trial
#4
Weiming Tang, Jessica Mao, Chuncheng Liu, Katie Mollan, Haochu Li, Terrence Wong, Ye Zhang, Songyuan Tang, Michael Hudgens, Yilu Qin, Baoli Ma, Meizhen Liao, Bin Yang, Wei Ma, Dianmin Kang, Chongyi Wei, Joseph D Tucker
BACKGROUND: The Chinese government now encourages innovation, and more specifically, crowdsourcing. Crowdsourcing, the process of shifting individual tasks to a large group, might reimagine health communication, making it more people-centred. We aimed to compare the effectiveness of a crowdsourced versus social marketing condom promotion video to promote condom use. METHODS: A non-inferiority randomised controlled trial was conducted in November 2015 in China. Men who have sex with men (MSM) aged 16 years or older who reported having had sexual contact without use of a condom in the preceding 3 months were recruited through a nationwide MSM website...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968886/recreational-drug-use-among-chinese-msm-results-from-a-national-wide-cross-sectional-study
#5
Peizhen Zhao, Songyuan Tang, Cheng Wang, Ye Zhang, John Best, Shujie Huang, Bin Yang, Chongyi Wei, Weiming Tang, Joseph D Tucker
BACKGROUND: In the past decade, recreational drug use has considerably increased among Chinese men who have sex with men (MSM). This increase has a great potential to worsen the scenario of the heavy burden of HIV among Chinese MSM. This study aimed to investigate the prevalence of recreational drug use, and to explore the association between poppers use and testing history for HIV or STIs, gay app use, and other sexual behaviours. METHODS: We recruited MSM who were born male and were aged 16 years or older through a nation-wide online survey in 2014...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968885/disclosure-of-sexual-orientation-in-men-who-have-sex-with-men-in-china-a-cross-sectional-survey
#6
Weiming Tang, Jessica Mao, Songyuan Tang, Chuncheng Liu, Katie Mollan, Terrence Wong, Ye Zhang, Michael Hudgens, Yilu Qin, Baoli Ma, Meizhen Liao, Bin Yang, Wei Ma, Dianmin Kang, Chongyi Wei, Joseph D Tucker
BACKGROUND: Most men who have sex with men (MSM) in China do not publicly disclose their sexual orientation. This low rate of disclosure may affect sexual behaviours, testing for HIV or other sexually transmitted infections (STIs), and disease transmission. This study examined factors associated with overall sexual orientation disclosure and disclosure to a healthcare professional. METHODS: We did a cross-sectional online survey of MSM in China from September 23, 2014, to October 8, 2014, through three national websites...
October 2016: Lancet
https://www.readbyqxmd.com/read/27905929/smoking-cessation-programmes-using-traditional-medicine-in-korea
#7
Soobin Jang, Yu Lee Park, Ju Ah Lee, Kyeong Han Kim, Eun-Kyoung Lee, Seung-Ho Sun, Yong-Cheol Shin, Seong-Gyu Ko, Sunju Park
BACKGROUND: There are growing interests in using various methods including traditional and complementary medicines (T&CM) for tobacco control. The study aimed to introduce how traditional Korean medicine (TKM) applied to smoking cessation programmes in Korea and to show the detail information of each programme for designing other smoke cessation programmes. METHODS: Reports of the smoke cessation programmes in Korea were searched on March 10th, 2016, from the webpages of the related agencies and the databases: the Ministry of Health and Welfare, the Korea Health Foundation, the Association of Korean Medicine, PubMed, Google scholar, the RISS, the KISS, the NDSL, and the OASIS...
December 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27824221/school-based-interventions-for-preventing-hiv-sexually-transmitted-infections-and-pregnancy-in-adolescents
#8
REVIEW
Amanda J Mason-Jones, David Sinclair, Catherine Mathews, Ashraf Kagee, Alex Hillman, Carl Lombard
BACKGROUND: School-based sexual and reproductive health programmes are widely accepted as an approach to reducing high-risk sexual behaviour among adolescents. Many studies and systematic reviews have concentrated on measuring effects on knowledge or self-reported behaviour rather than biological outcomes, such as pregnancy or prevalence of sexually transmitted infections (STIs). OBJECTIVES: To evaluate the effects of school-based sexual and reproductive health programmes on sexually transmitted infections (such as HIV, herpes simplex virus, and syphilis), and pregnancy among adolescents...
8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27806253/best-practices-and-innovations-for-managing-codeine-misuse-and-dependence
#9
Ian J Norman, Michael Bergin, Charles D Parry, Marie Claire Van Hout
PURPOSE: Promoting and ensuring safe use of codeine containing medicines remains a public health issue given the rise in reporting of misuse and dependence particularly in countries where available over-the-counter (OTC). The aim of this unique study was to identify best practices in management of opioid abuse and dependence, particularly codeine, and innovations to meet challenges surrounding safe and compliant use, patient awareness-raising, reducing health harms and enhancing successful treatment of dependence...
July 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27668015/accuracy-of-pharmaceutical-company-licensing-predictions-projected-versus-actual-licensing-dates
#10
Lucy Doos, Derek Ward, Andrew Stevens, Claire Packer
OBJECTIVES: To determine the accuracy of pharmaceutical companies' predictions of drug licensing timeframes for their products in late stage clinical development. METHODS: We compared predicted licensing dates provided to the National Institute for Health Research Horizon Scanning Research and Intelligence Centre by pharmaceutical companies against actual marketing authorisation application (MAA) and marketing authorisation (MA) dates published by the European Medicines Agency for drugs granted authorisation between 2009 and 2013...
June 2016: Journal of Pharmaceutical Health Services Research
https://www.readbyqxmd.com/read/27662261/children-s-medicine-what-do-consumers-really-want-to-know
#11
Clara Crunkhorn, Mieke van Driel, Van Nguyen, Treasure McGuire
AIM: This study explored consumer knowledge gaps and concerns regarding medication use in children. METHODS: Calls concerning or made by people under 18 to the pharmacist-operated, national consumer medicines call centre National Prescribing Service Medicines Line (2002 to June 2010) were analysed. Calls were classified and narratively explored by age group: <1, 1-4, 5-14 and 15-17 years. Consumer Medication Information (CMI) and evidence-based resources were examined to determine information concordance for common questions...
September 23, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27624748/women-s-questions-about-medicines-in-pregnancy-an-analysis-of-calls-to-an-australian-national-medicines-call-centre
#12
Eva L Pijpers, Sanne Kreijkamp-Kaspers, Treasure M McGuire, Laura Deckx, Wendy Brodribb, Mieke L van Driel
BACKGROUND: For many medicines, safe use during pregnancy is not established and adherence is often poor due to safety concerns. Therefore, it is important to identify consumers' medicines information needs during pregnancy. MATERIALS AND METHODS: A retrospective, mixed methods analysis was conducted on eight years of pregnancy-related calls to an Australian national medicines call centre. The call profile of pregnancy and non-pregnancy-related questions were compared...
September 14, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27623692/immunocap%C3%A2-isac-and-microtest-for-multiplex-allergen-testing-in-people-with-difficult-to-manage-allergic-disease-a-systematic-review-and-cost-analysis
#13
Marie Westwood, Bram Ramaekers, Shona Lang, Nigel Armstrong, Caro Noake, Shelley de Kock, Manuela Joore, Johan Severens, Jos Kleijnen
BACKGROUND: Allergy is a form of immune-mediated exaggerated sensitivity (hypersensitivity) to a substance that is either inhaled, swallowed, injected or comes into contact with the skin. Foreign substances that provoke allergies are called allergens. It has been claimed that multiplex allergen testing may help in diagnosing the cause of symptoms in patients with an unclear cause of allergy or who are allergic to more than one substance. OBJECTIVES: To evaluate multiplex allergen testing [devices that can measure the presence of multiple immunoglobulin E (IgE) antibodies in a patient's blood at the same time], by assessing (1) clinical effectiveness (allergy symptoms, incidence of acute exacerbations, mortality, adverse events of testing and treatment, health-care presentations or admissions, health-related quality of life); (2) effects on treatment (diet, immunotherapy medications, other potential testing); (3) any additional diagnostic information provided by multiplex allergen testing; and (4) cost-effectiveness (cost of different assessment strategies)...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27567768/actions-in-response-to-drug-safety-signals%C3%A2-arising-from-a-spontaneous-reporting%C3%A2-system-retrospective-study%C3%A2-in%C3%A2-the%C3%A2-netherlands
#14
Leàn Rolfes, Judith Kolfschoten, Florence van Hunsel, Michel Kooijman, Eugène van Puijenbroek
BACKGROUND: There is limited information on actions taken in response to drug safety signals originating from a spontaneous reporting system (SRS) in pharmacovigilance. In The Netherlands the Pharmacovigilance Centre Lareb is an independent organization that works in close collaboration with the Dutch regulatory agency, the Medicines Evaluation Board (MEB). OBJECTIVE: The objective of this study is to gain insight in steps undertaken on signals originating from the SRS and disseminated by Lareb from 2008-2012...
August 22, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27555884/the-evaluation-of-off-loading-using-a-new-removable-orthosis-in-diabetic-foot-orthodiab-randomized-controlled-trial-study-design-and-rational
#15
Kamel Mohammedi, Louis Potier, Maud François, Dured Dardari, Marilyne Feron, Estelle Nobecourt-Dupuy, Manuel Dolz, Roxane Ducloux, Abdelkader Chibani, Dominique-François Eveno, Teresa Crea Avila, Ariane Sultan, Laurence Baillet-Blanco, Vincent Rigalleau, Gilberto Velho, Florence Tubach, Ronan Roussel, Jean-Claude Dupré, Dominique Malgrange, Michel Marre
BACKGROUND: Off-loading is essential for diabetic foot management, but remains understudied. The evaluation of Off-loading using a new removable oRTHOsis in DIABetic foot (ORTHODIAB) trial aims to evaluate the efficacy of a new removable device "Orthèse Diabète" in the healing of diabetic foot. METHODS/DESIGN: ORTHODIAB is a French multi-centre randomized, open label trial, with a blinded end points evaluation by an adjudication committee according to the Prospective Randomized Open Blinded End-point...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/27540261/a-national-survey-to-identify-how-displacement-value-information-is-used-and-presented-to-clinical-staff-in-nhs-hospitals
#16
Nanna Christiansen, Zinab Kehk, Susan Keeling, Bryony Dean
AIM: The use of displacement values (DVs) when preparing intravenous (IV) medication for children enables accurate doses to be given1 and is assumed to be common paediatric practice. This survey aimed to assess views of UK paediatric pharmacists on DVs in practice to explore:▸ How prevalent is DV use in the paediatric hospital setting▸ Which type of IV administration guidelines were being used▸ Which form of DV presentation is perceived to be most practical▸ Which method of calculation is preferred METHOD: A national cross-sectional survey study was undertaken...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27527514/a-survey-of-patient-perspectives-on-the-research-use-of-health-information-and-biospecimens
#17
Stacey A Page, Kiran Pohar Manhas, Daniel A Muruve
BACKGROUND: Personal health information and biospecimens are valuable research resources essential for the advancement of medicine and protected by national standards and provincial statutes. Research ethics and privacy standards attempt to balance individual interests with societal interests. However these standards may not reflect public opinion or preferences. The purpose of this study was to assess the opinions and preferences of patients with kidney disease about the use of their health information and biospecimens for medical research...
2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27405974/has-the-biobank-bubble-burst-withstanding-the-challenges-for-sustainable-biobanking-in-the-digital-era
#18
REVIEW
Don Chalmers, Dianne Nicol, Jane Kaye, Jessica Bell, Alastair V Campbell, Calvin W L Ho, Kazuto Kato, Jusaku Minari, Chih-Hsing Ho, Colin Mitchell, Fruzsina Molnár-Gábor, Margaret Otlowski, Daniel Thiel, Stephanie M Fullerton, Tess Whitton
Biobanks have been heralded as essential tools for translating biomedical research into practice, driving precision medicine to improve pathways for global healthcare treatment and services. Many nations have established specific governance systems to facilitate research and to address the complex ethical, legal and social challenges that they present, but this has not lead to uniformity across the world. Despite significant progress in responding to the ethical, legal and social implications of biobanking, operational, sustainability and funding challenges continue to emerge...
2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27349639/acupuncture-and-related-interventions-for-symptoms-of-chronic-kidney-disease
#19
REVIEW
Kun Hyung Kim, Myeong Soo Lee, Tae-Hun Kim, Jung Won Kang, Tae-Young Choi, Jae Dong Lee
BACKGROUND: People living with chronic kidney disease (CKD) experience a range of symptoms and often have complex comorbidities. Many pharmacological interventions for people with CKD have known risks of adverse events. Acupuncture is widely used for symptom management in patients with chronic diseases and in other palliative care settings. However, the safety and efficacy of acupuncture for people with CKD remains largely unknown. OBJECTIVES: We aimed to evaluate the benefits and harms of acupuncture, electro-acupuncture, acupressure, moxibustion and other acupuncture-related interventions (alone or combined with other acupuncture-related interventions) for symptoms of CKD...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27306579/person-centred-medicines-optimisation-policy-in-england-an-agenda-for-research-on-polypharmacy
#20
Janet Heaton, Nicky Britten, Janet Krska, Joanne Reeve
: Aim To examine how patient perspectives and person-centred care values have been represented in documents on medicines optimisation policy in England. BACKGROUND: There has been growing support in England for a policy of medicines optimisation as a response to the rise of problematic polypharmacy. Conceptually, medicines optimisation differs from the medicines management model of prescribing in being based around the patient rather than processes and systems. This critical examination of current official and independent policy documents questions how central the patient is in them and whether relevant evidence has been utilised in their development...
January 2017: Primary Health Care Research & Development
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