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https://www.readbyqxmd.com/read/28943198/incidence-of-dementia-in-elderly-latin-americans-results-of-the-maracaibo-aging-study
#1
Gladys E Maestre, Luis J Mena, Jesus D Melgarejo, Daniel C Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J Chacon, Carlos A Chávez, Luis Falque-Madrid, Ciro A Gaona, Joseph D Terwilliger, Joseph H Lee, Nikolaos Scarmeas
INTRODUCTION: There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans. METHODS: The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) was used to diagnose dementia, which was classified as Alzheimer's disease, vascular dementia, or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years (p-y) of follow-up...
September 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28935620/a-lifestyle-intervention-via-email-in-minority-breast-cancer-survivors-randomized-parallel-group-feasibility-study
#2
Raheem J Paxton, Richard Hajek, Patricia Newcomb, Megha Dobhal, Sujana Borra, Wendell C Taylor, Deborah Parra-Medina, Shine Chang, Kerry S Courneya, Gladys Block, Torin Block, Lovell A Jones
BACKGROUND: Our data have indicated that minority breast cancer survivors are receptive to participating in lifestyle interventions delivered via email or the Web, yet few Web-based studies exist in this population. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary results of an email-delivered diet and activity intervention program, "A Lifestyle Intervention Via Email (ALIVE)," delivered to a sample of racial and ethnic minority breast cancer survivors...
September 21, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28934734/correlation-between-foot-arch-index-and-intensity-of-foot-knee-and-low-back-pain-among-pregnant-women-in-a-south-eastern-nigerian-community
#3
Chidiebele Petronilla Ojukwu, Emeka Godson Anyanwu, Ginika Gladys Nwafor
OBJECTIVES: To assess the arch height index of pregnant women and its correlation with foot pain, anterior knee pain and low back pain. SUBJECTS AND METHODS: Two hundred and fifteen (215) consenting pregnant women participated in this cross-sectional study. Arch height index was assessed from their foot prints while pain intensity was rated on a numerical pain rating scale. Data was summarized with descriptive statistics and Pearson's correlation was used to determine correlations between the variables at p<0...
September 19, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28928192/a-pragmatic-group-sequential-placebo-controlled-randomised-trial-to-determine-the-effectiveness-of-glyceryl-trinitrate-for-retained-placenta-got-it-a-study-protocol
#4
Fiona C Denison, John Norrie, Julia Lawton, Jane E Norman, Graham Scotland, Gladys C McPherson, Alison McDonald, Mark Forrest, Jemma Hudson, Jane Brewin, Mathilde Peace, Cynthia Clarkson, Sheonagh Brook-Smith, Susan Morrow, Nina Hallowell, Laura Hodges, Kathryn F Carruthers
INTRODUCTION: A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP). METHODS AND ANALYSIS: The aim of this pragmatic, randomised, placebo-controlled, double-blind UK-wide trial, with an internal pilot and nested qualitative research to adjust strategies to refine delivery of the main trial, is to determine whether sublingual glyceryl trinitrate (GTN) is (or is not) clinically and cost-effective for (medical) management of retained placenta...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927458/sybr-green-based-one-step-quantitative-real-time-polymerase-chain-reaction-assay-for-the-detection-of-zika-virus-in-field-caught-mosquitoes
#5
Wei-Ping Tien, Gareth Lim, Gladys Yeo, Suzanna Nicole Chiang, Chee-Seng Chong, Lee-Ching Ng, Hapuarachchige Chanditha Hapuarachchi
BACKGROUND: The monitoring of vectors is one of the key surveillance measures to assess the risk of arbovirus transmission and the success of control strategies in endemic regions. The recent re-emergence of Zika virus (ZIKV) in the tropics, including Singapore, emphasizes the need to develop cost-effective, rapid and accurate assays to monitor the virus spread by mosquitoes. As ZIKV infections largely remain asymptomatic, early detection of ZIKV in the field-caught mosquitoes enables timely implementation of appropriate mosquito control measures...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28923896/experimental-and-theoretical-approaches-to-investigate-the-immunogenicity-of-taenia-solium-derived-ke7-antigen
#6
Raúl J Bobes, José Navarrete-Perea, Adrián Ochoa-Leyva, Víctor Hugo Anaya, Marisela Hernández, Jacquelynne Cervantes-Torres, Karel Estrada, Filiberto Sánchez-Lopez, Xavier Soberón, Gabriela Rosas, Cáris Maroni Nunes, Martín García-Varela, Rogerio Rafael Sotelo-Mundo, Alonso Alexis López-Zavala, Goar Gevorkian, Gonzalo Acero, Juan P Laclette, Gladis Fragoso, Edda Sciutto
Taenia solium cysticercosis, a parasitic disease that affects human health in various regions of the world, is preventable by vaccination. Both the 97-amino-acid-long KETc7 peptide and its carboxyl-terminal, 18-amino-acid-long sequence (GK-1) are found in Taenia crassiceps Both peptides, with proven protective capacity against cysticercosis, are part of the highly conserved, cestode-native, 264-amino-acid long protein KE7. KE7 belongs to a ubiquitously distributed family of proteins associated to membrane processes and may participate in several vital cell pathways...
September 18, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28922974/the-achilles-heel-of-prevention-to-mother-to-child-transmission-of-hiv-protocol-implementation-uptake-and-sustainability
#7
Violeta J Rodriguez, Richard P LaCabe, C Kyle Privette, K Marie Douglass, Karl Peltzer, Gladys Matseke, Audrey Mathebula, Shandir Ramlagan, Sibusiso Sifunda, Guillermo Willy Prado, Viviana Horigian, Stephen M Weiss, Deborah L Jones
The Joint United Nations Programme on HIV and AIDS proposed to reduce the vertical transmission of HIV from ∼72,200 to ∼8300 newly infected children by 2015 in South Africa (SA). However, cultural, infrastructural, and socio-economic barriers hinder the implementation of the prevention of mother-to-child transmission (PMTCT) protocol, and research on potential solutions to address these barriers in rural areas is particularly limited. This study sought to identify challenges and solutions to the implementation, uptake, and sustainability of the PMTCT protocol in rural SA...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/28922294/health-professionals-quality-of-life-in-relation-to-end-of-life-care
#8
Juan P Linzitto, Gladys Grance
PURPOSE OF REVIEW: Palliative care professionals are frequently exposed to stressful and demanding situations in the assistance of patients and their families, therefore research related to their quality of life is a relevant topic to provide evidence on interventions oriented to professional self-care. RECENT FINDINGS: Research about professionals' quality of life is having a profuse development with core concepts being under review. SUMMARY: Currently, burnout syndrome and compassion fatigue are considered relevant determinants of professionals' quality of life...
September 15, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28912211/body-mass-index-is-associated-with-microvascular-endothelial-dysfunction-in-patients-with-treated-metabolic-risk-factors-and-suspected-coronary-artery-disease
#9
Dirk J van der Heijden, Maarten A H van Leeuwen, Gladys N Janssens, Mattie J Lenzen, Peter M van de Ven, Etto C Eringa, Niels van Royen
BACKGROUND: Obesity is key feature of the metabolic syndrome and is associated with high cardiovascular morbidity and mortality. Obesity is associated with macrovascular endothelial dysfunction, a determinant of outcome in patients with coronary artery disease. Here, we compared the influence of obesity on microvascular endothelial function to that of established cardiovascular risk factors such as diabetes mellitus, hypertension, hypercholesterolemia, and smoking in patients with suspected coronary artery disease...
September 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28902845/clinical-and-epidemiologic-characteristics-of-dengue-and-other-etiologic-agents-among-patients-with-acute-febrile-illness-puerto-rico-2012-2015
#10
Kay M Tomashek, Olga D Lorenzi, Doris A Andújar-Pérez, Brenda C Torres-Velásquez, Elizabeth A Hunsperger, Jorge Luis Munoz-Jordan, Janice Perez-Padilla, Aidsa Rivera, Gladys E Gonzalez-Zeno, Tyler M Sharp, Renee L Galloway, Mindy Glass Elrod, Demetrius L Mathis, M Steven Oberste, W Allan Nix, Elizabeth Henderson, Jennifer McQuiston, Joseph Singleton, Cecilia Kato, Carlos García Gubern, William Santiago-Rivera, Jesús Cruz-Correa, Robert Muns-Sosa, Juan D Ortiz-Rivera, Gerson Jiménez, Ivonne E Galarza, Kalanthe Horiuchi, Harold S Margolis, Luisa I Alvarado
Identifying etiologies of acute febrile illnesses (AFI) is challenging due to non-specific presentation and limited availability of diagnostics. Prospective AFI studies provide a methodology to describe the syndrome by age and etiology, findings that can be used to develop case definitions and multiplexed diagnostics to optimize management. We conducted a 3-year prospective AFI study in Puerto Rico. Patients with fever ≤7 days were offered enrollment, and clinical data and specimens were collected at enrollment and upon discharge or follow-up...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28898296/characterizing-the-interaction-between-physicians-pharmacists-and-pharmaceutical-representatives-in-a-middle-income-country-a-qualitative-study
#11
Rima Hajjar, Aya Bassatne, Mohamad Ali Cheaito, Rabie Naser El Dine, Sarah Traboulsy, Fadi Haddadin, Gladys Honein-AbouHaidar, Elie A Akl
BACKGROUND: Studies around the world have shown that interactions between pharmaceutical companies, pharmacists and physicians have a great influence on prescribing and drug dispensing practices. In middle-income countries, the nature and extent of these interactions have not been well researched. Our objectives were to qualitatively explore the nature of the interactions between pharmaceutical companies, physicians and pharmacists, their impact on drug prescription and dispensing practices in Lebanon...
2017: PloS One
https://www.readbyqxmd.com/read/28895487/-%C3%A2-like-because-you-are-a-grownup-you-do-not-need-help-experiences-of-transition-from-pediatric-to-adult-care-among-youth-with-perinatal-hiv-infection-their-caregivers-and-health-care-providers-in-the-dominican-republic
#12
María C Pinzón-Iregui, Gladys Ibanez, Consuelo Beck-Sagué, Mina Halpern, Rosa M Mendoza
With the introduction of combination antiretroviral therapy (ART) worldwide, youth with perinatal HIV infection are increasingly surviving childhood and transitioning to adult care. Although a normal life span is anticipated posttransition, successful transition to adult HIV care has proven difficult, with worse outcomes posttransition than in pediatric and adult care. This study is a qualitative analysis of data from 4 focus groups of pre- and posttransition patients, caregivers, and healthcare providers in the Dominican Republic at an institution that provides comprehensive treatment including ART for HIV-infected persons of all ages...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28892380/gne-781-a-highly-advanced-potent-and-selective-bromodomain-inhibitor-of-cyclic-adenosine-monophosphate-response-element-binding-protein-binding-protein-cbp
#13
F Anthony Romero, Jeremy Murray, Kwong Wah Lai, Vickie Tsui, Brian K Albrecht, Le An, Maureen H Beresini, Gladys de Leon Boenig, Sarah M Bronner, Emily W Chan, Kevin X Chen, Zhongguo Chen, Edna F Choo, Kyle Clagg, Kevin Clark, Terry D Crawford, Patrick Cyr, Denise de Almeida Nagata, Karen E Gascoigne, Jane L Grogan, Georgia Hatzivassiliou, Wei Huang, Thomas L Hunsaker, Susan Kaufman, Stefan G Koenig, Ruina Li, Yingjie Li, Xiaorong Liang, Jiangpeng Liao, Wenfeng Liu, Justin Ly, Jonathan Maher, Colin Masui, Mark Merchant, Yingqing Ran, Alexander M Taylor, John Wai, Fei Wang, Xiaocang Wei, Dong Yu, Bing-Yan Zhu, Xiaoyu Zhu, Steven Magnuson
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent and selective over BRD4(1). In pursuit of a more potent and selective CBP inhibitor, we used structure-based design. Constraining the aniline of 1 into a tetrahydroquinoline motif maintained potency and increased selectivity 2-fold. Structure-activity relationship studies coupled with further structure-based design targeting the LPF shelf, BC loop, and KAc regions allowed us to significantly increase potency and selectivity, resulting in the identification of non-CNS penetrant 19 (GNE-781, TR-FRET IC50 = 0...
September 21, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28889294/using-light-activated-enzymes-for-modulating-intracellular-c-di-gmp-levels-in-bacteria
#14
Min-Hyung Ryu, Anastasia Fomicheva, Lindsey O'Neal, Gladys Alexandre, Mark Gomelsky
Signaling pathways involving second messenger c-di-GMP regulate various aspects of bacterial physiology and behavior. We describe the use of a red light-activated diguanylate cyclase (c-di-GMP synthase) and a blue light-activated c-di-GMP phosphodiesterase (hydrolase) for manipulating intracellular c-di-GMP levels in bacterial cells. We illustrate the application of these enzymes in regulating several c-di-GMP-dependent phenotypes, i.e., motility and biofilm phenotypes in E. coli and chemotactic behavior in the alphaproteobacterium Azospirillum brasilense...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28887140/envisioning-women-centered-hiv-care-perspectives-from-women-living-with-hiv-in-canada
#15
Nadia O'Brien, Saara Greene, Allison Carter, Johanna Lewis, Valerie Nicholson, Gladys Kwaramba, Brigitte Ménard, Elaina Kaufman, Nourane Ennabil, Neil Andersson, Mona Loutfy, Alexandra de Pokomandy, Angela Kaida
BACKGROUND: Women comprise nearly one-quarter of people living with human immunodeficiency virus (HIV) in Canada. Compared with men, women living with HIV experience inequities in HIV care and health outcomes, prompting a need for gendered and tailored approaches to HIV care. METHOD: Peer and academic researchers from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study conducted focus groups to understand women's experience of seeking care, with the purpose of identifying key characteristics that define a women-centered approach to HIV care...
September 5, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28886013/secondary-bacterial-infections-and-antibiotic-resistance-among-tungiasis-patients-in-western-kenya
#16
Ruth Monyenye Nyangacha, David Odongo, Florence Oyieke, Missiani Ochwoto, Richard Korir, Ronald Kiprotich Ngetich, Gladys Nginya, Olipher Makwaga, Christine Bii, Peter Mwitari, Festus Tolo
Tungiasis or jigger infestation is a parasitic disease caused by the female sand flea Tunga penetrans. Secondary infection of the lesions caused by this flea is common in endemic communities. This study sought to shed light on the bacterial pathogens causing secondary infections in tungiasis lesions and their susceptibility profiles to commonly prescribed antibiotics. Participants were recruited with the help of Community Health Workers. Swabs were taken from lesions which showed signs of secondary infection...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28882681/provider-communication-with-adolescent-and-young-females-during-sexual-and-reproductive-health-visits-findings-from-the-2011-2015-national-survey-of-family-growth
#17
Nicole Liddon, Riley J Steiner, Gladys M Martinez
OBJECTIVE: National guidelines advise providers to counsel patients about contraception and condom use during sexual and reproductive health care visits. This study assesses provider communication with adolescent and young women about birth control, emergency contraception, and condoms during such visits. STUDY DESIGN: Using data from sexually active 15-24year old women participating in the 2011-2015 National Survey of Family Growth, we examined prevalence of provider communication about birth control, emergency contraception and condoms when receiving other sexual and reproductive health services in the past year...
September 4, 2017: Contraception
https://www.readbyqxmd.com/read/28882101/perceptions-about-the-cultural-practices-of-male-partners-during-postpartum-care-in-rural-tanzania-a-qualitative-study
#18
Gladys Reuben Mahiti, Columba K Mbekenga, Angwara Dennis Kiwara, Anna-Karin Hurtig, Isabel Goicolea
BACKGROUND: Men play an important role in maternal health. The postpartum period is a critical stage, yet there is a scarcity of research that explores men's involvement during this stage. OBJECTIVE: The aim of the study was to explore male partners' perceptions of the cultural practices during postpartum care in rural Tanzania. METHODS: Fourteen focus group discussions were conducted with 93 men, with an age range of 19-65 years, in August 2013...
2017: Global Health Action
https://www.readbyqxmd.com/read/28880813/associations-between-trauma-exposure-religious-coping-and-psychiatric-distress-in-a-community-sample-in-nairobi-kenya
#19
Hana J Shin, Gladys Mwiti, Melinda Tomosada, Cynthia B Eriksson
Adults (N = 703) in Nairobi, Kenya completed a screening survey in the aftermath of the postelection violence (PEV) of 2008. This study examined associations between exposure to PEV, prior trauma exposure, religious coping, and psychiatric distress. Results indicated a dose-response effect of the amount of PEV and prior trauma exposure on the severity of concurrent symptoms of psychiatric distress. Over 90% of the sample reported a religious affiliation, and the majority of participants also reported frequent use of religious coping strategies...
October 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28874959/clinical-impact-of-confocal-laser-endomicroscopy-in-the-management-of-gastrointestinal-lesions-with-an-uncertain-diagnosis
#20
Carlos Robles-Medranda, Maria Vargas, Jesenia Ospina, Miguel Puga-Tejada, Manuel Valero, Miguel Soria, Gladys Bravo, Carlos Robles-Jara, Hannah Pitanga Lukashok
AIM: To evaluate the clinical impact of confocal laser endomicroscopy (CLE) in the diagnosis and management of patients with an uncertain diagnosis. METHODS: A retrospective chart review was performed. Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included. Baseline characteristics, indications, previous diagnostic studies, findings at the time of CLE, clinical management and histological results were analyzed...
August 16, 2017: World Journal of Gastrointestinal Endoscopy
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