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https://www.readbyqxmd.com/read/28093222/swainsonine-induced-lysosomal-storage-disease-in-goats-caused-by-the-ingestion-of-sida-rodrigoi-monteiro-in-north-western-argentina
#1
Juan Francisco Micheloud, Raúl Marin, Luis Adrian Colque-Caro, Olga Gladys Martínez, Dale Gardner, Eduardo Juan Gimeno
There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins...
January 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28092821/efficacy-of-vacuum-steam-pasteurization-for-inactivation-of-salmonella-pt-30-escherichia-coli-o157-h7-and-enterococcus-faecium-on-low-moisture-foods
#2
Manoj K Shah, Gladys Asa, Julie Sherwood, Kari Graber, Teresa M Bergholz
Low moisture foods such as nuts, spices, and seeds have been implicated in several outbreaks due to Salmonella or E. coli O157:H7 contamination. Such foods may be consumed raw, and can be used as ingredients in other food products. While numerous thermal inactivation studies have been conducted for Salmonella on nuts, studies on other seeds and grains are minimal. Product water activity can influence the thermal resistance of pathogens, where thermal resistance increases as water activity decreases, leading to a requirement for higher temperatures and longer exposure times to achieve significant reduction of pathogen numbers...
January 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28069296/inflammatory-early-events-associated-to-the-role-of-p2x7-receptor-in-acute-murine-toxoplasmosis
#3
Gladys Corrêa, Carolina de Almeida Lindenberg, Aline Cristina de Abreu Moreira-Souza, Luiz Eduardo Baggio Savio, Christina Maeda Takiya, Camila Marques-da-Silva, Rossiane Claudia Vommaro, Robson Coutinho-Silva
Activation of the purinergic P2X7 receptor by extracellular ATP (eATP) potentiates proinflammatory responses during infections by intracellular pathogens. Extracellular ATP triggers an antimicrobial response in macrophages infected with Toxoplasma gondii in vitro, suggesting that purinergic signaling may stimulate host defense mechanisms against toxoplasmosis. Here, we provide in vivo evidence in support of this hypothesis, by showing that P2X7(-/-) mice are more susceptible than P2X7(+/+) mice to acute infection by the RH strain of T...
December 30, 2016: Immunobiology
https://www.readbyqxmd.com/read/28063855/low-dietary-soy-isoflavonoids-increase-hippocampal-spine-synapse-density-in-ovariectomized-rats
#4
Neil J MacLusky, Gladis Thomas, Csaba Leranth
High dietary intake of plant estrogens (phytoestrogens) can affect brain structure and function. The effects of phytoestrogen intake within the range of normal animal and human dietary consumption, however, remain uncertain. The aim of the present study was to determine the effects of the isoflavonoids present in a standard low phytoestrogen laboratory rat chow on spine synapse density in the stratum radiatum of area CA1 of the hippocampus. Weanling rats (22 days old) were fed either standard chow (Teklad 2018), a nutritionally comparable diet without soy (Teklad 2016) or a custom diet containing Teklad 2016 supplemented with the principal soy isoflavonoids, daidzein and genistein, for 40 days...
January 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28061839/risk-factors-for-mortality-in-tb-patients-a-10-year-electronic-record-review-in-a-south-african-province
#5
J Christo Heunis, N Gladys Kigozi, Perpetual Chikobvu, Sonja Botha, Hcj Dingie van Rensburg
BACKGROUND: Since 1990, reduction of tuberculosis (TB) mortality has been lower in South Africa than in other high-burden countries in Africa. This research investigated the influence of routinely captured demographic and clinical or programme variables on death in TB patients in the Free State Province. METHODS: A retrospective review of case information captured in the Electronic TB register (ETR.net) over the years 2003 to 2012 was conducted. Extracted data were subjected to descriptive and logistic regression analyses...
January 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28061427/municipal-waste-liquor-treatment-via-bioelectrochemical-and-fermentation-h2%C3%A2-%C3%A2-ch4-processes-assessment-of-various-technological-sequences
#6
Tamás Rózsenberszki, László Koók, Péter Bakonyi, Nándor Nemestóthy, Washington Logroño, Mario Pérez, Gladys Urquizo, Celso Recalde, Róbert Kurdi, Attila Sarkady
In this paper, the anaerobic treatment of a high organic-strength wastewater-type feedstock, referred as the liquid fraction of pressed municipal solid waste (LPW) was studied for energy recovery and organic matter removal. The processes investigated were (i) dark fermentation to produce biohydrogen, (ii) anaerobic digestion for biogas formation and (iii) microbial fuel cells for electrical energy generation. To find a feasible alternative for LPW treatment (meeting the two-fold aims given above), various one- as well as multi-stage processes were tested...
December 23, 2016: Chemosphere
https://www.readbyqxmd.com/read/28052810/clinical-effectiveness-and-cost-effectiveness-of-surgical-options-for-the-management-of-anterior-and-or-posterior-vaginal-wall-prolapse-two-randomised-controlled-trials-within-a-comprehensive-cohort-study-results-from-the-prospect-study
#7
Cathryn Glazener, Suzanne Breeman, Andrew Elders, Christine Hemming, Kevin Cooper, Robert Freeman, Anthony Smith, Suzanne Hagen, Isobel Montgomery, Mary Kilonzo, Dwayne Boyers, Alison McDonald, Gladys McPherson, Graeme MacLennan, John Norrie
BACKGROUND: The use of mesh in prolapse surgery is controversial, leading to a number of enquiries into its safety and efficacy. OBJECTIVE: To compare synthetic non-absorbable mesh inlay, biological graft and mesh kit with a standard repair in terms of clinical effectiveness, adverse effects, quality of life (QoL), costs and cost-effectiveness. DESIGN: Two randomised controlled trials within a comprehensive cohort (CC) study. Allocation was by a remote web-based randomisation system in a 1 :1 : 1 ratio (Primary trial) or 1 : 1 : 2 ratio (Secondary trial), and was minimised on age, type of prolapse repair planned, need for a concomitant continence procedure, need for a concomitant upper vaginal prolapse procedure and surgeon...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28050539/comparative-analysis-of-pain-in-patients-who-underwent-total-knee-replacement-regarding-the-tourniquet-pressure
#8
Marcos George de Souza Leão, Gladys Pedrosa Martins Neta, Lucas Inoue Coutinho, Thiago Montenegro da Silva, Yacov Machado Costa Ferreira, Waryla Raissa Vasconcelos Dias
OBJECTIVES: To evaluate through the visual analog scale (VAS) the pain in patients undergoing total knee replacement (TKR) with different pressures of the pneumatic tourniquet. METHODS: An observational, randomized, descriptive study on an analytical basis, with 60 patients who underwent TKR, divided into two groups, which were matched: a group where TKR was performed with tourniquet pressures of 350 mmHg (standard) and the other with systolic blood pressure plus 100 mmHg (P + 100)...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28045611/establishment-of-personalized-pain-goals-in-oncology-patients-to-improve-care-and-decrease-costs
#9
Dylan Zylla, Amber Larson, Gladys Chuy, Lisa Illig, Adina Peck, Sarah Van Peursem, James W Fulbright, Pamala A Pawloski, Sara Richter, Jeanne Mettner
PURPOSE: Cancer-related pain is common, negatively affects quality of life and survival, and often requires treatment with opioid analgesics. Patient-reported data that describe the incidence and severity of pain, medication use, and patient satisfaction with care are lacking. METHODS: We analyzed 18 months of outpatient oncology clinic encounters from the electronic medical record to obtain data on pain levels and opioid and nonopioid treatments. In June 2014, we instituted a pain intervention by creating a pain management information handout for patients, educating clinicians on opioid cost-effectiveness, and implementing a nursing protocol to document personalized pain goals (PPGs)...
January 3, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28044465/in-situ-quantification-of-diverse-titanium-dioxide-nanoparticles-unveils-selective-endoplasmic-reticulum-stress-dependent-toxicity
#10
Marina Simon, Gladys Saez, Giovanna Muggiolu, Magali Lavenas, Quentin Le Trequesser, Claire Michelet, Guillaume Devès, Philippe Barberet, Eric Chevet, Denis Dupuy, Marie-Hélène Delville, Hervé Seznec
Although titanium dioxide nanoparticles (TiO2 NPs) have been extensively studied, their possible impact on health due to their specific properties supported by their size and geometry, remains to be fully characterized to support risk assessment. To further document NPs biological effects, we investigated the impact of TiO2 NPs morphology on biological outcomes. To this end, TiO2 NPs were synthesized as nanoneedles (NNs), titanate scrolled nanosheets (TNs), gel-sol-based isotropic nanoparticle (INPs) and tested for perturbation of cellular homeostasis (cellular ion content, cell proliferation, stress pathways) in three cell types and compared to the P25...
January 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28044462/freeze-drying-optimization-of-polymeric-nanoparticles-for-ocular-flurbiprofen-delivery-effect-of-protectant-agents-and-critical-process-parameters-on-long-term-stability
#11
Gladys Rosario Ramos Yacasi, Ana Cristina Calpena Capmany, María Antonia Egea Gras, Marta Espina García, María Luisa García López
CONTEXT: The stabilization of flurbiprofen loaded poly-Ɛ-caprolactone nanoparticles (FB-PƐCL-NPs) for ocular delivery under accurate freeze-drying (FD) process provide the basis for a large-scale production and its commercial development. OBJECTIVE: Optimization of the FD to improve long term stability of ocular administration's FB-PƐCL-NPs Methods: FB-PƐCL-NPs were prepared by solvent displacement method with poloxamer 188 (P188) as stabilizer. Freezing and primary dying (PD) were studied and optimized through freeze-thawing test and freeze-drying microscopy...
January 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28035647/offending-behavior-drug-use-and-mental-health-among-foreign-born-versus-u-s-born-latino-criminal-justice-clients
#12
Gladys E Ibañez, Michelle Agudo, Steve S Martin, Daniel J O'Connell, Rehab Auf, Diana M Sheehan
Little is known about the offending behavior and recidivism factors of Latinos by nativity (U.S. born, foreign-born). The present study focused on Latinos in community corrections (n = 201) in Miami, Florida, and examined differences in criminal activity, drug use, and mental health by nativity. Data were collected utilizing convenience sampling between June 2014 and December 2015. The research question was: what are the offending, drug use, and mental health histories of Latinos involved in community corrections? Participants were mostly male (n = 120; 59...
December 30, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28010989/mesh-graft-or-standard-repair-for-women-having-primary-transvaginal-anterior-or-posterior-compartment-prolapse-surgery-two-parallel-group-multicentre-randomised-controlled-trials-prospect
#13
Cathryn Ma Glazener, Suzanne Breeman, Andrew Elders, Christine Hemming, Kevin G Cooper, Robert M Freeman, Anthony Rb Smith, Fiona Reid, Suzanne Hagen, Isobel Montgomery, Mary Kilonzo, Dwayne Boyers, Alison McDonald, Gladys McPherson, Graeme MacLennan, John Norrie
BACKGROUND: The use of transvaginal mesh and biological graft material in prolapse surgery is controversial and has led to a number of enquiries into their safety and efficacy. Existing trials of these augmentations are individually too small to be conclusive. We aimed to compare the outcomes of prolapse repair involving either synthetic mesh inlays or biological grafts against standard repair in women. METHODS: We did two pragmatic, parallel-group, multicentre, randomised controlled trials for our study (PROSPECT [PROlapse Surgery: Pragmatic Evaluation and randomised Controlled Trials]) in 35 centres (a mix of secondary and tertiary referral hospitals) in the UK...
December 20, 2016: Lancet
https://www.readbyqxmd.com/read/28009289/blood-stage-malaria-disrupts-humoral-immunity-to-the-pre-erythrocytic-stage-circumsporozoite-protein
#14
Gladys J Keitany, Karen S Kim, Akshay T Krishnamurty, Brian D Hondowicz, William O Hahn, Nicholas Dambrauskas, D Noah Sather, Ashley M Vaughan, Stefan H I Kappe, Marion Pepper
Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria-endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts. We hypothesized that pre-erythrocytic humoral immunity is directly disrupted by blood stage infection. To investigate this possibility, we used Plasmodium-antigen tetramers to analyze B cells after infection with either late liver stage arresting parasites or wild-type parasites that progress to the blood stage...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/27997442/intrasession-and-intersession-repeatability-of-diffusion-tensor-imaging-in-healthy-human-liver
#15
Oi Lei Wong, Thomas Wai Tong Leung, Gladys Goh Lo, Jing Yuan, Wing Wa Li, Michael D Noseworthy
OBJECTIVE: The aim of this study was to evaluate the effect of signal to noise ratio (SNR) and number of gradient directions (NGD) on intra- and intersession repeatability of liver diffusion tensor imaging (DTI) metrics. METHODS: At each of 3 liver DTI scan sessions, liver diffusion was assessed in 5 healthy volunteers using a 6-direction DTI scan performed 9 separate times (ie, number of signal averages [NSA]). In addition, 4 combinations of NSA and NGD were acquired (NSA/NGD = 1/30, 3/10, 3/12, and 5/6) to determine the combined effect to DTI metrics, which was based on intersubject variability and intrasession (Vintra) and intersession (Vinter) repeatability...
December 15, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27995428/epiploic-appendagitis-a-benign-process-at-risk-of-unnecessary-hospitalization-and-interventions
#16
Stephen E Kessler, Gladys Martin
No abstract text is available yet for this article.
December 19, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27986585/sexual-functioning-of-men-and-women-with-severe-obesity-before-bariatric-surgery
#17
Kristine J Steffen, Wendy C King, Gretchen E White, Leslee L Subak, James E Mitchell, Anita P Courcoulas, David R Flum, Gladys Strain, David B Sarwer, Ronette L Kolotkin, Walter Pories, Alison J Huang
BACKGROUND: Obesity may impair sexual function through multiple mechanisms, but little is known about sexual dysfunction among adults with severe obesity seeking bariatric procedures. OBJECTIVES: To describe sexual function and associated factors before bariatric surgery. SETTING: Ten U.S. clinical facilities. METHODS: Before bariatric surgery, 2225 of 2458 Longitudinal Assessment of Bariatric Surgery-2 study participants (79% female, median age 45 years and median body mass index 46 kg/m(2)) completed a survey about sexual function over the past month...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27956009/maintenance-pharmacotherapy-normalizes-the-relapse-curve-in-recently-abstinent-tobacco-smokers-with-schizophrenia-and-bipolar-disorder
#18
A Eden Evins, Susanne S Hoeppner, David A Schoenfeld, Bettina B Hoeppner, Corinne Cather, Gladys N Pachas, Kristina M Cieslak, Melissa Culhane Maravic
OBJECTIVE: To compare the effect of maintenance pharmacotherapy on sustained abstinence rates between recently abstinent smokers with schizophrenia and bipolar disorder (SBD) and general population smokers without psychiatric illness. METHOD: We performed a person-level, pooled analysis of two randomized controlled trials of maintenance varenicline, conducted in adult smokers with SBD and general population smokers, controlling for severity of dependence. Smokers abstinent after 12-weeks of open varenicline treatment were randomly assigned to ≥12-weeks maintenance varenicline or identical placebo...
December 9, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27918626/evolutionary-origins-of-abnormally-large-shoot-sodium-accumulation-in-nonsaline-environments-within-the-caryophyllales
#19
Philip J White, Helen C Bowen, Martin R Broadley, Hamed A El-Serehy, Konrad Neugebauer, Anna Taylor, Jacqueline A Thompson, Gladys Wright
The prevalence of sodium (Na)-'hyperaccumulator' species, which exhibit abnormally large shoot sodium concentrations ([Na]shoot ) when grown in nonsaline environments, was investigated among angiosperms in general and within the Caryophyllales order in particular. Shoot Na concentrations were determined in 334 angiosperm species, representing 35 orders, grown hydroponically in a nonsaline solution. Many Caryophyllales species exhibited abnormally large [Na]shoot when grown hydroponically in a nonsaline solution...
December 5, 2016: New Phytologist
https://www.readbyqxmd.com/read/27915004/economic-analysis-of-the-nairobi-cancer-registry-implications-for-expanding-and-enhancing-cancer-registration-in-kenya
#20
Anne Korir, Robai Gakunga, Sujha Subramanian, Nathan Okerosi, Gladys Chesumbai, Patrick Edwards, Florence Tangka, Rachael Joseph, Nathan Buziba, Victor Rono, Donald Maxwell Parkin, Mona Saraiya
INTRODUCTION: Cancer registration is an important activity for informing cancer control activities. Cancer registries in Sub-Saharan Africa have limited resources to effectively operate because of competing priorities. To date, there has not been an assessment of the resources and funding needed to perform all the activities essential for cancer registration in Kenya. Evidence will help registries to quantify and advocate for the funds needed to sustain, enhance, and expand high quality cancer registration in Kenya...
December 2016: Cancer Epidemiology
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