Mahdi Moqri, Chiara Herzog, Jesse R Poganik, Kejun Ying, Jamie N Justice, Daniel W Belsky, Albert T Higgins-Chen, Brian H Chen, Alan A Cohen, Georg Fuellen, Sara Hägg, Riccardo E Marioni, Martin Widschwendter, Kristen Fortney, Peter O Fedichev, Alex Zhavoronkov, Nir Barzilai, Jessica Lasky-Su, Douglas P Kiel, Brian K Kennedy, Steven Cummings, P Eline Slagboom, Eric Verdin, Andrea B Maier, Vittorio Sebastiano, Michael P Snyder, Vadim N Gladyshev, Steve Horvath, Luigi Ferrucci
The search for biomarkers that quantify biological aging (particularly 'omic'-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. Here, we review current efforts to evaluate the predictive validity of omic biomarkers of aging in population studies, discuss challenges in comparability and generalizability and provide recommendations to facilitate future validation of biomarkers of aging...
February 14, 2024: Nature Medicine