keyword
MENU ▼
Read by QxMD icon Read
search

DUAL

keyword
https://www.readbyqxmd.com/read/28110457/reduced-proliferation-and-colony-formation-of-head-and-neck-squamous-cell-carcinoma-hnscc-after-dual-targeting-of-egfr-and-hedgehog-pathways
#1
Hannes Liebig, Georg Günther, Marlen Kolb, Christian Mozet, Andreas Boehm, Andreas Dietz, Gunnar Wichmann
PURPOSE: The hedgehog signalling pathway (Hh) is frequently active in head and neck squamous cell carcinoma (HNSCC). Overexpressed Hh associates with poor prognosis. The Hh inhibitor vismodegib targets smoothened, and based on molecular data, may prevent resistance to EGFR targeting. METHODS: To elucidate potential roles of vismodegib in HNSCC therapy, its sole effects and those combined with cisplatin, docetaxel, and cetuximab on HNSCC cell lines were assessed by MTT metabolisation and BrdU incorporation...
January 21, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28110443/aerobic-endurance-training-does-not-protect-bone-against-poorly-controlled-type-1-diabetes-in-young-adult-rats
#2
Tom J Hazell, T Dylan Olver, Hana Kowalchuk, Matthew W McDonald, Adwitia Dey, Kenneth N Grisé, Earl G Noble, C W James Melling, Paula Lavery, Hope A Weiler
Streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) decreases trabecular bone volume and bone strength in rodents. The current study investigated the potential protective effects of aerobic endurance training (AET) on bone in STZ-induced T1DM young adult rats. Sixty-four 8-week-old male Sprague-Dawley rats were randomly divided into 4 groups of 16: control non-T1DM sedentary (CS) and exercised (CX), T1DM sedentary (DS) and exercised (DX). Blood glucose was maintained at 9-15 mmol/L using subcutaneously implanted insulin pellets (Linplant, Linshin Canada, Inc...
January 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28110296/three-six-or-twelve-months-of-dual-antiplatelet-therapy-after-des-implantation-in-patients-with-or-without-acute-coronary-syndromes-an-individual-patient-data-pairwise-and-network-meta-analysis-of-six-randomized-trials-and-11%C3%A2-473-patients
#3
Tullio Palmerini, Diego Della Riva, Umberto Benedetto, Letizia Bacchi Reggiani, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Marco Valgimigli, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Park, Antonio Colombo, Alaide Chieffo, Diego Sangiorgi, Giuseppe Biondi-Zoccai, Philippe Généreux, Gianni D Angelini, Maria Pufulete, Jonathon White, Deepak L Bhatt, Gregg W Stone
AIM: We sought to determine whether the optimal dual antiplatelet therapy (DAPT) duration after drug-eluting stent (DES) placement varies according to clinical presentation. METHODS AND RESULTS: We performed an individual patient data pairwise and network meta-analysis comparing short-term (≤6-months) versus long-term (1-year) DAPT as well as 3-month vs. 6-month vs 1-year DAPT. The primary study outcome was the 1-year composite risk of myocardial infarction (MI) or definite/probable stent thrombosis (ST)...
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28110154/factors-associated-with-electronic-cigarette-use-among-current-cigarette-smoking-adolescents-in-the-republic-of-korea
#4
Sunhee Park, Haein Lee, Soyoon Min
OBJECTIVE: Despite a rapid increase in electronic cigarette (e-cigarette) use and substantial dual use of cigarettes and e-cigarettes among adolescents, little is currently known about adolescent e-cigarette use. Thus, this study aimed to investigate (a) rates of e-cigarette use and (b) significant factors associated with e-cigarette use among current cigarette users in adolescence. METHODS: We analyzed secondary data collected from a nationally representative sample of Korean adolescents...
January 4, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28109959/crispr-cas9-mediated-genome-editing-as-a-therapeutic-approach-for-leber-congenital-amaurosis-10
#5
Guo-Xiang Ruan, Elizabeth Barry, Dan Yu, Michael Lukason, Seng H Cheng, Abraham Scaria
As the most common subtype of Leber congenital amaurosis (LCA), LCA10 is a severe retinal dystrophy caused by mutations in the CEP290 gene. The most frequent mutation found in patients with LCA10 is a deep intronic mutation in CEP290 that generates a cryptic splice donor site. The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy. Here, we show that targeted genomic deletion using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system represents a promising therapeutic approach for the treatment of patients with LCA10 bearing the CEP290 splice mutation...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28109945/discovery-of-a-series-of-n-5-quinolin-6-yl-pyridin-3-yl-benzenesulfonamides-as-pi3k-mtor-dual-inhibitors
#6
Jiankang Zhang, Xiaoqing Lv, Xiaodong Ma, Yongzhou Hu
Recently, the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been considered as promising targets for the treatment of cancer. Herein, we synthesized a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as novel PI3K/mTOR dual inhibitors for cancer therapy. In the biological evaluation, compound 17e was identified as a potent PI3K/mTOR dual inhibitor, which significantly inhibit Class I PI3Ks, mTOR and phosphorylation of pAkt(Ser473) at low nanomolar level. Moreover, 17e display high potency against PC-3 cells (IC50 = 80 nM) in the anti-proliferative assay, and showed acceptable pharmacokinetic properties in vivo...
January 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28109932/accuracy-of-noncontrast-quiescent-interval-single-shot-lower-extremity-mr-angiography-versus-ct%C3%A2-angiography-for-diagnosis-of-peripheral-artery-disease-comparison-with-digital-subtraction-angiography
#7
Akos Varga-Szemes, Julian L Wichmann, U Joseph Schoepf, Pal Suranyi, Carlo N De Cecco, Giuseppe Muscogiuri, Damiano Caruso, Ricardo T Yamada, Sheldon E Litwin, Christian Tesche, Taylor M Duguay, Shivraman Giri, Rozemarijn Vliegenthart, Thomas M Todoran
OBJECTIVES: This study sought to evaluate the image quality and diagnostic accuracy of noncontrast quiescent-interval single-shot (QISS) magnetic resonance angiography (MRA) versus iodine-contrast computed tomography angiography (CTA) in patients with peripheral artery disease (PAD), with invasive digital subtraction angiography (DSA) as the reference standard. BACKGROUND: QISS is a recently introduced noncontrast MRA technique. Although the diagnostic accuracy of QISS is reportedly similar to that of contrast-enhanced MRA, its performance compared with contrast-enhanced CTA, the most frequently used noninvasive modality for evaluation of PAD, is unknown...
January 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109887/compressed-sensing-based-simultaneous-black-and-gray-blood-carotid-vessel-wall-mr-imaging
#8
Bo Li, Hao Li, Hanjing Kong, Li Dong, Jue Zhang, Jing Fang
OBJECTIVE: In this study, we sought to demonstrate the blood suppression performance, image quality and morphological measurements for compressed sensing (CS) based simultaneous 3D black- and gray-blood imaging sequence (CS-siBLAG) in carotid vessel wall MR imaging. MATERIALS AND METHODS: Seven healthy volunteers and five patients were recruited. Healthy subjects underwent five CS-siBLAG scans with 1, 2, 3, 4 and 5-fold accelerations. Signal-to-tissue ratio (STR) and contrast-to-tissue ratios (CTR) were computed as the measures of flowing signal suppression performance and the image quality for black-blood imaging of the technique...
January 18, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28109885/hetero-and-homodimerization-of-arabidopsis-thaliana-arginine-decarboxylase-atadc1-and-atadc2
#9
Israel Maruri-López, Juan F Jiménez-Bremont
The arginine decarboxylase enzyme (ADC) carries out the production of agmatine from arginine, which is the precursor of the first polyamine (PA) known as putrescine; subsequently, putrescine is turned into the higher PAs, spermidine and spermine. In Arabidopsis thaliana PA production occurs only from arginine and this step is initiated by two ADC paralogous, AtADC1 and AtADC2. PA production is essential for A. thaliana life cycle. Here, we analyzed the sub-cellular localization of AtADC1 and AtADC2 enzymes through GFP translational fusions...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109872/5-year-safety-and-efficacy-of-resolute%C3%A2-zotarolimus-eluting-stent-the-resolute-global-clinical-trial-program
#10
Robert W Yeh, Sigmund Silber, Lianglong Chen, Shaoliang Chen, Shirish Hiremath, Franz-Josef Neumann, Shubin Qiao, Shigeru Saito, Bo Xu, Yuejin Yang, Laura Mauri
OBJECTIVES: The authors evaluated the 5-year cumulative incidence of cardiovascular events following Resolute zotarolimus-eluting stent (R-ZES) implantation. BACKGROUND: Individual trials are often underpowered to show differences for low-frequency adverse events. The R-ZES was studied in 10 prospective clinical trials, designed with identical adverse event definitions, ascertainment, and adjudication. METHODS: The RESOLUTE Global Clinical Trial Program includes 7,618 patients treated with R-ZES: RESOLUTE first-in-human study (N = 139), RESOLUTE All Comers (N = 1,140), RESOLUTE International (N = 2,349), RESOLUTE US (N = 1,402), RESOLUTE US 38 mm (N = 114), RESOLUTE Japan (N = 100), RESOLUTE Japan Small Vessel Study (N = 65), RESOLUTE Asia (N = 311), RESOLUTE China Randomized Controlled Trial (N = 198), and RESOLUTE China Registry (N = 1,800)...
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109635/impact-of-high-cholesterol-in-a-parkinson-s-disease-model-prevention-of-lysosomal-leakage-versus-stimulation-of-%C3%AE-synuclein-aggregation
#11
Ida Eriksson, Sangeeta Nath, Per Bornefall, Ana Maria Villamil Giraldo, Karin Öllinger
Parkinson's disease is characterized by accumulation of intraneuronal cytoplasmic inclusions, Lewy bodies, which mainly consist of aggregated α-synuclein. Controversies exist as to whether high blood cholesterol is a risk factor for the development of the disease and whether statin treatment could have a protective effect. Using a model system of BE(2)-M17 neuroblastoma cells treated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)), we found that MPP(+)-induced cell death was accompanied by cholesterol accumulation in a lysosomal-like pattern in pre-apoptotic cells...
January 16, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28109551/-economic-impact-of-optimising-antiretroviral-treatment-in-human-immunodeficiency-virus-infected-adults-with-suppressed-viral-load-in-spain-by-implementing-the-grade-a-1-evidence-recommendations-of-the-2015-gesida-national-aids-plan
#12
Esteban Ribera, José Manuel Martínez-Sesmero, Javier Sánchez-Rubio, Rafael Rubio, Juan Pasquau, José Luis Poveda, Alejandro Pérez-Mitru, Celia Roldán, Beatriz Hernández-Novoa
INTRODUCTION: The objective of this study is to estimate the economic impact associated with the optimisation of triple antiretroviral treatment (ART) in patients with undetectable viral load according to the recommendations from the GeSIDA/PNS (2015) Consensus and their applicability in the Spanish clinical practice. METHODS: A pharmacoeconomic model was developed based on data from a National Hospital Prescription Survey on ART (2014) and the A-I evidence recommendations for the optimisation of ART from the GeSIDA/PNS (2015) consensus...
January 18, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28109435/an-overview-of-advanced-silac-labeling-strategies-for-quantitative-proteomics
#13
F Terzi, S Cambridge
Comparative, quantitative mass spectrometry of proteins provides great insight to protein abundance and function, but some molecular characteristics related to protein dynamics are not so easily obtained. Because the metabolic incorporation of stable amino acid isotopes allows the extraction of distinct temporal and spatial aspects of protein dynamics, the SILAC methodology is uniquely suited to be adapted for advanced labeling strategies. New SILAC strategies have emerged that allow deeper foraging into the complexity of cellular proteomes...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109423/moving-beyond-the-debate-over-restricting-sugary-drinks-in-the-supplemental-nutrition-assistance-program
#14
EDITORIAL
Marlene B Schwartz
To address the dual problem of food insecurity and poor nutrition, the U.S. Department of Agriculture has recently revised the nutrition standards for nearly all of its federal food programs to align with the Dietary Guidelines for Americans. One notable exception is the Supplemental Nutrition Assistance Program (SNAP). Policy proposals to restrict SNAP benefits based on nutrition quality (e.g., excluding sugary drinks) have generated controversy and have polarized previous research and advocacy allies. This essay presents many of the issues that have emerged, which include challenges about the feasibility, justification, and effectiveness of restricting benefits; the risk of a slippery slope; concerns about participant dignity; and finally, distrust about the motives behind promoting and opposing a policy change...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28109420/improving-nutrition-by-increasing-supplemental-nutrition-assistance-program-benefits
#15
Ann M Collins, Jacob A Klerman
The diets of Americans fall far short of recommended dietary guidelines, and those who live in low-income households have even poorer diets than higher-income households. Many low-income Americans rely on the Supplemental Nutrition Assistance Program (SNAP). The program's dual goals are to improve food security and nutrition. Among the possible strategies to address dietary shortfalls among low-income Americans is to increase the SNAP benefit. This article uses data from the random assignment evaluation of the Summer Electronic Benefit Transfer for Children demonstration to add new insights on the impact of SNAP on diet quality for households receiving SNAP who also received SNAP-like benefits through Summer Electronic Benefit Transfer for Children...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28109264/health-related-quality-of-life-in-patients-with-chronic-hepatitis-c-receiving-sofosbuvir-based-treatment-with-and-without-interferon-a-prospective-observational-study-in-egypt
#16
Naglaa F A Youssef, Mohamed El Kassas, Amany Farag, Ashley Shepherd
BACKGROUND: The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of these new DAAs therapies on patient reported outcomes (PROs). This study aimed to (1) assess the PROs (health-related quality of life (HRQoL), mental health and perceived social support) of HCV patients receiving DAAs therapy prior, during and at the end of therapy; (2) evaluate PROs of Interferon-free (dual) users versus Interferon-containing (triple) users cross the three different time periods; and (3) identify the predictors of HRQoL of DAAs therapy users cross the three different time periods...
January 21, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28109184/comparative-cardiovascular-risks-of-dipeptidyl-peptidase-4-inhibitors-with-other-2-nd-and-3-rd-line-antidiabetic-drugs-in-patients-with-type-2-diabetes
#17
Huang-Tz Ou, Kai-Cheng Chang, Chung-Yi Li, Jin-Shang Wu
AIMS: Dipeptidyl peptidase-4 inhibitors (DPP4i) are suggested as 2(nd) and 3(rd) add-on antidiabetic treatment for type 2 diabetes. Previous studies only assessed cardiovascular effects of DPP4i as 2(nd) line treatment, included sulfonylurea as only one comparator, and yielded inconclusive results on the risk of heart failure. This study therefore evaluated comparative cardiovascular risks of DPP4i with other 2(nd) and 3(rd) line antidiabetic drugs. METHODS: Based on a large nation-wide diabetic cohort, 113,051 patients with type 2 diabetes newly on metformin-based dual or triple therapy were identified in 2009-2011 and followed until death or 2013...
January 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28109166/a-novel-dual-amylin-and-calcitonin-receptor-agonist-dacra-kbp-089-induces-weight-loss-through-a-reduction-in-fat-but-not-lean-mass-while-improving-food-preference
#18
Sofie Gydesen, Sara Toftegaard Hjuler, Zenia Freving, Kim Vietz Andreassen, Nina Sonne, Lars I Hellgren, Morten Asser Karsdal, Kim Henriksen
BACKGROUND AND PURPOSE: Obesity and associated co-morbidities, such as type 2 diabetes and non-alcoholic fatty liver disease, are major health challenges - hence, development of weight loss therapies with the ability to reduce the co-morbidities is key. EXPERIMENTAL APPROACH: The effect of the dual amylin and calcitonin receptor agonist (DACRA), KBP-089, on bodyweight, glucose homeostasis, and fatty acid accumulation in liver and muscle tissue, food preference was investigated...
January 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28109076/microrna-409-3p-represses-glioma-cell-invasion-and-proliferation-by-targeting-high-mobility-group-nucleosome-binding-domain-5
#19
Yidong Cao, Liang Zhang, Minghao Wei, Xue Jiang, Dong Jia
Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development andprogression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109073/cyclin-dependent-kinase-inhibitor-3-promotes-cancer-cell-proliferation-and-tumorigenesis-in-nasopharyngeal-carcinoma-by-targeting-p27
#20
Huimin Wang, Hexin Chen, Hang Zhou, Wenfa Yu, Zhenmin Lu
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy with high invasion which arises from the nasopharynx epithelium. Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family which plays a key role in regulating cell division. Abnormal expression of CDKN3 has been found in numerous types of cancer. In the current study, we explored the possible role of CDKN3 in cell proliferation, invasion ability and radiosensitivity in NPC cells. We reported that CDKN3 was upregulated and P27 was downregulated in NPC tissues and associated with worse patient prognosis...
January 20, 2017: Oncology Research
keyword
keyword
10150
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"