Beatriz Guillen-Guio, Megan L Paynton, Richard J Allen, Daniel P W Chin, Lauren J Donoghue, Amy Stockwell, Olivia C Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan, Fernando Martinez, Helen L Booth, William A Fahy, Ian P Hall, Simon P Hart, Mike R Hill, Nik Hirani, Richard B Hubbard, Robin J McAnulty, Ann B Millar, Vidya Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Ian Sayers, Martin D Tobin, Moira K B Whyte, Ayodeji Adegunsoye, Naftali Kaminski, Shwu-Fan Ma, Mary E Strek, Yingze Zhang, Tasha E Fingerlin, Maria Molina-Molina, Margaret Neighbors, X Rebecca Sheng, Justin M Oldham, Toby M Maher, Philip L Molyneaux, Carlos Flores, Imre Noth, David A Schwartz, Brian L Yaspan, R Gisli Jenkins, Louise V Wain, Edward J Hollox
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF and a prior association of the HLA-DQB1 gene with idiopathic fibrotic interstitial pneumonia (including IPF) has been reported. Due to the important role that the Human Leukocyte Antigen (HLA) region plays in the immune response, here we evaluated if HLA genetic variation was associated specifically with IPF risk...
July 24, 2023: medRxiv