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Pulmonary infection and polymorphism

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https://www.readbyqxmd.com/read/27853145/marco-variants-are-associated-with-phagocytosis-pulmonary-tuberculosis-susceptibility-and-beijing-lineage
#1
N T T Thuong, T T B Tram, T D Dinh, P V K Thai, D Heemskerk, N D Bang, T T H Chau, D G Russell, G E Thwaites, T R Hawn, M Caws, S J Dunstan
Macrophage receptor with collagenous structure (MARCO) has an important role in the phagocytosis of Mycobacterium tuberculosis (M. tuberculosis). We hypothesized that MARCO polymorphisms are associated with phagocytosis, tuberculosis (TB) disease susceptibility and presentation, and infecting lineage. We used a human cellular model to examine how MARCO genotype mediates the immune response; a case-control study to investigate tuberculosis host genetic susceptibility; and a host-pathogen genetic analysis to study host-pathogen interactions...
December 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27847023/protein-tyrosine-phosphatase-nonreceptor-type-22-ptpn22-gene-polymorphism-in-pulmonary-tuberculosis-in-the-indian-population
#2
Vydyanath R Narasimha, Kalpana Panati, M Gangadhara Reddy, Venkata Ramireddy Narala
A variant of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene is known to be associated with susceptibility to autoimmune diseases and bacterial infections as it acts as an important regulator of T-cell activation. The objective of this study was to evaluate whether PTPN22-C1858T polymorphism is associated with the resistance to pulmonary tuberculosis (PTB). Single-nucleotide polymorphism of PTPN22-C1858T (rs2476601) was genotyped in 124 patients with PTB and 130 healthy controls from India using restriction fragment length polymorphism and direct sequencing of the amplified DNA...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27826348/complete-heart-block-in-association-with-dengue-hemorrhagic-fever
#3
Hafeez Ul Hassan Virk, Faisal Inayat, Zia Ur Rahman
Dengue virus infection affects the heart structurally and functionally. Clinical manifestations of cardiac complications secondary to dengue virus infection vary from self-limiting arrhythmias to severe myocardial infarction, leading to hypotension, pulmonary edema, and cardiogenic shock. However, we report a case of dengue hemorrhagic fever (DHF) complicated by a complete heart block. A female with DHF due to dengue virus serotype 2, presented to the emergency department with fever, headache, rash, and fatigue followed by an episode of syncope...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27812036/association-of-mannose-binding-lectin-polymorphisms-with-tuberculosis-susceptibility-among-chinese
#4
Cheng Liu, Tao He, Yanxiao Rong, Fengjiao Du, Dongxing Ma, Yujie Wei, Zhiqin Mei, Yuling Wang, Haibin Wang, Yuehua Zhu, Zongde Zhang, Li Zheng, Xueqiong Wu, Huiliang Liu, Wenjun Ding
Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across the MBL2 gene were genotyped by direct DNA sequencing of PCR products in a case-control population of Chinese Han origin, consisting of 1,020 patients with pulmonary TB and 1,020 controls...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27764878/environmental-and-genetic-risk-factors-associated-with-venous-thromboembolism
#5
Marta Crous-Bou, Laura B Harrington, Christopher Kabrhel
Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism, and a combination of environmental and genetic risk factors contributes to VTE risk. Within environmental risk factors, some are provoking (e.g., cancer, surgery, trauma or fracture, immobilization, pregnancy and the postpartum period, long-distance travel, hospitalization, catheterization, and acute infection) and others are nonprovoking (e.g., age, sex, race/ethnicity, body mass index and obesity, oral contraceptive or hormone therapy use, corticosteroid use, statin use, diet, physical activity, sedentary time, and air pollution)...
November 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27668525/ccl5-rs2107538-polymorphism-increased-the-risk-of-tuberculosis-in-a-sample-of-iranian-population
#6
Hamid Reza Kouhpayeh, Mohsen Taheri, Mana Baziboroon, Mohammad Naderi, Gholamreza Bahari, Mohammad Hashemi
Cysteine-cysteine chemokine ligand 5 (CCL5) with immunoregulatory and inflammatory activities has an important role in granuloma formations that activates and stimulates T-cells and macrophages. Cysteine-cysteine chemokine receptor 5 (CCR5) is a chemokine receptor, which is important for migration of immune cells to site of infection. In the present study we investigated the possible association between CCL5 -403G/A (rs2107538), CCL5 -28C/G (rs2280788) and CCR5 Δ32 polymorphisms and pulmonary tuberculosis (PTB) in an Iranian population...
2016: Prague Medical Report
https://www.readbyqxmd.com/read/27643598/role-of-lta4h-polymorphism-in-tuberculosis-associated-immune-reconstitution-inflammatory-syndrome-occurrence-and-clinical-severity-in-patients-infected-with-hiv
#7
Gopalan Narendran, Dhanasekaran Kavitha, Ramesh Karunaianantham, Leonardo Gil-Santana, Jilson L Almeida-Junior, Sirasanambatti Devarajulu Reddy, Marimuthu Makesh Kumar, Haribabu Hemalatha, Nagesh Nalini Jayanthi, Narayanan Ravichandran, Raja Krishnaraja, Angamuthu Prabhakar, Tamizhselvan Manoharan, Lokeswaran Nithyananthan, Gunasundari Arjunan, Mohan Natrajan, Soumya Swaminathan, Bruno B Andrade
BACKGROUND: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide polymorphism (SNP) in the LTA4H promoter which regulates its transcriptional activity (rs17525495) has been identified and described to impact clinical severity of TB presentation and response to corticosteroid therapy...
2016: PloS One
https://www.readbyqxmd.com/read/27573645/evaluation-of-genetic-diversity-of-candida-spp-and-klebsiella-spp-isolated-from-the-denture-plaque-of-copd-patients
#8
D Przybyłowska, K Piskorska, M Gołaś, M Sikora, E Swoboda-Kopeć, J Kostrzewa-Janicka, E Mierzwińska-Nastalska
Yeast-like fungi and gram-negative bacilli are the most frequent potential pathogens of the respiratory tract isolated from the denture plaque of patients with chronic obstructive pulmonary disease (COPD). Dominant species among yeast-like fungi are Candida albicans and Candida tropicalis. Significant frequency is also exhibited by Klebsiella pneumoniae and Klebsiella oxytoca. The purpose of this study was to analyze genetic diversity of the strains of C. albicans, C. tropicalis, and Klebsiella spp. present in patients in stable phases of COPD...
August 30, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27521485/high-levels-of-plasma-interferon-gamma-and-874t-a-gene-polymorphism-is-associatedwithhiv-tb-co-infection
#9
V R Gutlapalli, Aparna Sykam, Sandeep P Tenali, Sujai Suneetha, Lavanya M Suneetha
OBJECTIVE: Tuberculosis (TB) is one of the most frequent opportunistic infections in HIV patients leading to increased morbidity and death rate. This study was carried out to investigate the role of the cytokines IFN-γ and TNF-α level and their single nucleotide polymorphisms (SNPs) in HIV-TB co-infection. METHODS: 247 HIV-TB (124 HIV-pulmonary TB, 123 HIV-extra pulmonary TB), 126 HIV positive individuals without tuberculosis and 129 healthy subjects (HS) were included to measure plasma levels of IFN-γ and TNF-α by sandwich ELISA and One way ANOVA statistical analysis was carried out among the groups...
August 10, 2016: Human Immunology
https://www.readbyqxmd.com/read/27506391/molecular-epidemiology-of-mycobacterium-africanum-in-ghana
#10
Adwoa Asante-Poku, Isaac Darko Otchere, Stephen Osei-Wusu, Esther Sarpong, Akosua Baddoo, Audrey Forson, Clement Laryea, Sonia Borrell, Frank Bonsu, Jan Hattendorf, Collins Ahorlu, Kwadwo A Koram, Sebastien Gagneux, Dorothy Yeboah-Manu
BACKGROUND: Mycobacterium africanum comprises two phylogenetic lineages within the M. tuberculosis complex (MTBC) and is an important cause of human tuberculosis (TB) in West Africa. The reasons for this geographic restriction of M. africanum remain unclear. Here, we performed a prospective study to explore associations between the characteristics of TB patients and the MTBC lineages circulating in Ghana. METHOD: We genotyped 1,211 MTBC isolates recovered from pulmonary TB patients recruited between 2012 and 2014 using single nucleotide polymorphism typing and spoligotyping...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27498617/paragonimus-westermani-infection-mimicking-recurrent-lung-cancer-a-case-report
#11
Naoya Itoh, Mika Tsukahara, Hiroshi Yamasaki, Yasuyuki Morishima, Hiromu Sugiyama, Hanako Kurai
Herein, we report a case of Paragonimus westermani infection, which required differentiation from recurrent lung cancer. A 66-year old Japanese man with a history of lung cancer who had undergone a lobectomy was referred to our clinic for treatment of cough, sputum, dyspnea, and a right pulmonary nodule. He had previously eaten seafood he visited China. P. westermani infection was confirmed by the presence of antibody against P. westermani antigen in the patient's serum and eggs in his sputum. Eventually, molecular identification by PCR-restriction fragment length polymorphism analysis and sequencing confirmed that the patient was infected with triploid forms of P...
August 5, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27485354/human-ulk1-variation-and-susceptibility-to-mycobacterium-tuberculosis-infection
#12
David J Horne, Andrew D Graustein, Javeed A Shah, Glenna Peterson, Meg Savlov, Sergio Steele, Masahiro Narita, Thomas R Hawn
BACKGROUND: Unlike tuberculosis, few studies have evaluated a host genetic basis for variability in susceptibility to latent Mycobacterium tuberculosis infection (LTBI). We performed a candidate gene association study of autophagy-related genes and LTBI. METHODS: We enrolled close contacts of individuals with pulmonary tuberculosis, assessed LTBI status, and determined clinical and sociodemographic risk factors for LTBI. In participants who self-identified as Asian or black, we compared haplotype-tagging single-nucleotide polymorphisms (SNPs) in ULK1 and GABARAP between cases (n = 143) and controls (n = 106)...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27325005/association-of-polymorphisms-of-the-transporter-associated-with-antigen-processing-tap2-gene-with-pulmonary-tuberculosis-in-an-elderly-japanese-population
#13
Kaung Si Thu, Noriko Sato, Shinobu Ikeda, Makiko Naka-Mieno, Tomio Arai, Seijiro Mori, Motoji Sawabe, Masaaki Muramatsu, Masashi Tanaka
The transporter associated with antigen processing 2 (TAP2) gene is involved in the immunological response to tuberculosis (TB) infection. Variations in the TAP2 gene have been associated with TB infection in small population studies in India, Columbia, and Korea. We investigated the association of TAP2 polymorphisms with TB susceptibility in an elderly Japanese population. We analyzed samples from consecutive autopsy cases (n = 1850) registered in the Japanese Geriatric SNP Research database. TB was diagnosed pathologically by TB granuloma on autopsy samples...
August 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27276844/lack-of-association-between-il-10-gene-promoter-polymorphisms-and-susceptible-to-tuberculosis-in-thai-patients
#14
Manaphol Kulpraneet, Anirut Limtrakul, Surangrat Srisurapanon, Piyatida Tangteerawatana
BACKGROUND: Cytokines play a major role in defense against Mycobacterium tuberculosis infection. Polymorphisms in the genes encoding various cytokines have been associated with tuberculosis susceptibility. Polymorphisms of the regulatoy cytokine gene, the interleukin (IL)-10 is associated with the risk of tuberculosis (TB) in different populations. However IL-10 gene polymorphism and susceptibility to TB in Thai is still unknown. OBJECTIVE: The purpose of this study was to evaluate whether the common IL-10 promoter gene polymorphisms are associated with TB in Thai population...
November 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27173292/genetic-variability-in-isolates-of-chromobacterium-violaceum-from-pulmonary-secretion-water-and-soil
#15
A C Santini, J T Magalhães, J C M Cascardo, R X Corrêa
Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain ATCC 12472, and seven isolates from the environment and one from a pulmonary secretion from a chromobacteriosis patient from Ilhéus, Bahia. The molecular characterization of all samples was performed by polymerase chain reaction (PCR) sequencing and 16S rDNA analysis...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27156628/functional-polymorphisms-of-the-tlr7-and-tlr8-genes-contribute-to-mycobacterium-tuberculosis-infection
#16
Yung-Fa Lai, Tsun-Mei Lin, Chiou-Huey Wang, Pei-Yi Su, Jiun-Ting Wu, Meng-Chih Lin, Hock-Liew Eng
Tuberculosis (TB) has recently re-emerged as a major global public health threat and Mycobacterium tuberculosis (MTB) is a highly successful pathogen that evolved remarkable strategies to establish persistent infection. There is strong evidence that host genetic factors influence individual susceptibility to TB. In this study, we evaluated the associations between the TLR7 and TLR8 genetic polymorphisms and TB susceptibility in Chinese individuals. The results demonstrated that the frequency of the TLR8-129C allele was higher in male patients with pulmonary TB than in healthy controls (22...
May 2016: Tuberculosis
https://www.readbyqxmd.com/read/27114869/genetic-signatures-of-mycobacterium-tuberculosis-nonthaburi-genotype-revealed-by-whole-genome-analysis-of-isolates-from-tuberculous-meningitis-patients-in-thailand
#17
Olabisi Oluwabukola Coker, Angkana Chaiprasert, Chumpol Ngamphiw, Sissades Tongsima, Sanjib Mani Regmi, Taane G Clark, Rick Twee Hee Ong, Yik-Ying Teo, Therdsak Prammananan, Prasit Palittapongarnpim
Genome sequencing plays a key role in understanding the genetic diversity of Mycobacterium tuberculosis (M.tb). The genotype-specific character of M. tb contributes to tuberculosis severity and emergence of drug resistance. Strains of M. tb complex can be classified into seven lineages. The Nonthaburi (NB) genotype, belonging to the Indo-Oceanic lineage (lineage 1), has a unique spoligotype and IS6110-RFLP pattern but has not previously undergone a detailed whole genome analysis. In addition, there is not much information available on the whole genome analysis of M...
2016: PeerJ
https://www.readbyqxmd.com/read/27101784/inflammasome-genetics-contributes-to-the-development-and-control-of-active-pulmonary-tuberculosis
#18
D Souza de Lima, M M Ogusku, A Sadahiro, A Pontillo
Tuberculosis (TB) continues to be a major public health problem. An estimated one-third of the world's population is infected with Mycobacterium tuberculosis (Mtb) but remains asymptomatic (latent TB) and only 5% to 10% of these latent individuals will develop active pulmonary TB. Factors affecting the balance between latent and active TB are mostly unknown, even if host genome has been shown to contribute to the outcome of Mtb response. Acute inflammation and Th1 response are important in the early clearance of the bacteria as it was emphasized by the association between immune genes (i...
July 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27082601/relationship-among-chlamydia-and-mycoplasma-pneumoniae-seropositivity-ikzf1-genotype-and-chronic-obstructive-pulmonary-disease-in-a-general-japanese-population-the-nagahama-study
#19
Shigeo Muro, Yasuharu Tabara, Hisako Matsumoto, Kazuya Setoh, Takahisa Kawaguchi, Meiko Takahashi, Isao Ito, Yutaka Ito, Kimihiko Murase, Chikashi Terao, Shinji Kosugi, Ryo Yamada, Akihiro Sekine, Takeo Nakayama, Kazuo Chin, Michiaki Mishima, Fumihiko Matsuda
Chronic obstructive pulmonary disease (COPD) is a possible risk factor for cardiovascular disease. The association of COPD with the pathogenicity of infection with Chlamydia pneumoniae and Mycoplasma pneumoniae is controversial. We conducted a cross-sectional study to clarify the association between atypical pneumoniae seropositivity and COPD in a general population. We also investigated genetic polymorphisms conferring susceptibility to a pneumonia titer. The study included 9040 Japanese subjects (54 ± 13 years)...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27067904/regulatory-role-of-cdx-2-and-taq-i-polymorphism-of-vitamin-d-receptor-gene-on-chemokine-expression-in-pulmonary-tuberculosis
#20
M Harishankar, P Selvaraj
Vitamin D receptor (VDR) gene variants have been shown to be regulating the immune response in tuberculosis. We studied the regulatory role of VDR promoter Cdx-2 and 3'UTR TaqI gene variants on chemokine levels from culture filtrate antigen (CFA) stimulated with or without 1,25(OH)2D3 treated peripheral blood mononuclear cells of 50 pulmonary tuberculosis patients (PTB) and 51 normal healthy controls (HCs). In CFA with 1,25(OH)2D3 treated cultures, the MIP-1α, MIP-1β, RANTES levels were significantly decreased in Cdx-2 AA genotype compared to GG genotype, while a significantly increased MIG level was observed in Cdx-2 AA genotype (p<0...
June 2016: Human Immunology
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