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relapsed and refactory multiple myeloma

Jacob P Laubach, Robert L Schlossman, Constantine S Mitsiades, Kenneth C Anderson, Paul G Richardson
The field of multiple myeloma therapeutics has been an active one for many years, but perhaps no more so than in the past decade. The introduction of thalidomide, lenalidomide and bortezomib in the treatment of this disease highlights clinical advances made during this period. While these agents were initially utilized in the setting of relapsed and refactory disease, they are now part of the therapeutic armamentarium for transplant-eligible and transplant-ineligible patients with newly diagnosed multiple myeloma...
February 2011: Expert Review of Hematology
Haimei Chen, Robert C MacDonald, Shuyou Li, Nancy L Krett, Steven T Rosen, Thomas V O'Halloran
Arsenic trioxide (ATO, As2O3) is emerging as a front line agent for treatment of acute promyelocytic leukemia with giving a complete remission rate of 83-95%. ATO also shows significant activity in relapsed/refactory multiple myeloma; however, efforts to expand clinical utility to other cancers have been limited by its toxicity profile at higher doses. New bioavailable, liposome encapsulated As(III) materials exhibit a significantly attenuated cytotoxicity that undergoes pH-triggered release of an active drug...
October 18, 2006: Journal of the American Chemical Society
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