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https://www.readbyqxmd.com/read/27914146/pregnancy-and-delivery-in-a-generalized-dystonia-patient-treated-with-internal-globus-pallidal-deep-brain-stimulation-a-case-report
#1
Hye Ran Park, Jae Meen Lee, Hyeyoung Park, Chae Won Shin, Han Joon Kim, Hee Pyoung Park, Dong Gyu Kim, Beom Seok Jeon, Sun Ha Paek
Internal globus pallidus (GPi) deep brain stimulation (DBS) has been widely accepted as an effective treatment modality of medically refractory dystonia. However, there have been few studies regarding the safety issue of pregnancy and childbirth related with DBS. This report describes a female patient who was pregnant and delivered a baby after GPi DBS surgery. A 33-year-old female patient with acquired generalized dystonia underwent bilateral GPi DBS implantation. She obtained considerable improvement in both movement and disability after DBS implantation...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27909104/loss-of-plasticity-in-the-d2-accumbens-pallidal-pathway-promotes-cocaine-seeking
#2
J A Heinsbroek, D N Neuhofer, W C Griffin, G S Siegel, A-C Bobadilla, Y M Kupchik, P W Kalivas
Distinct populations of D1- and D2-dopamine receptor expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, while activity in D2-MSNs inhibits motivated behaviors. We used chemogenetics to extend D1-/D2-MSN cell specific regulation to cue-reinstated cocaine seeking in a mouse model of self-administration and relapse, and found that either increasing activity in D1-MSNs or decreasing activity in D2-MSNs augmented cue-induced reinstatement. Both D1- and D2-MSNs provide substantial GABAergic innervation to the ventral pallidum, and chemogenetic inhibition of ventral pallidal neurons blocked the augmented reinstatement elicited by chemogenetic regulation of either D1- or D2-MSNs...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27871916/association-of-neurobehavioral-performance-with-r2-in-the-caudate-nucleus-of-asymptomatic-welders
#3
Eun-Young Lee, Paul J Eslinger, Michael R Flynn, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Lan Kong, Richard B Mailman, Xuemei Huang
OBJECTIVES: Welding fumes contain several metals including manganese (Mn) and iron (Fe) that may affect the nervous system. Previous studies of potential welding-related neurotoxicity have focused primarily on Mn exposure. The current study examined neurobehavioral and brain imaging changes in asymptomatic welders and their associations with both Mn and Fe exposure measurements. METHODS: Data were obtained from subjects with (n=46) and without (controls; n=31) a history of welding exposure...
November 18, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27852779/ventral-pallidum-output-pathways-in-context-induced-reinstatement-of-alcohol-seeking
#4
Asheeta A Prasad, Gavan P McNally
: Ventral pallidum (VP) is a well-established locus for the reinforcing effects of drugs of abuse and reinstatement of drug seeking. However, VP neurons are at the origin of multiple output pathways, with strong projections to ventral tegmental area (VTA), subthalamic nucleus (STN), lateral hypothalamus, among others, and the roles of these VP output pathways in reinstatement of drug seeking remain poorly understood. Here we addressed these issues using a combination of neuroanatomical tracing and chemogenetic approaches...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27820618/pallidal-deep-brain-stimulation-for-the-treatment-of-levodopa-responsive-juvenile-dystonia-and-parkinsonism-secondary-to-spg11-mutation
#5
Adolfo Ramirez-Zamora, Lucy Gee, Youngwon Youn, Damian S Shin, Julie G Pilitsis
No abstract text is available yet for this article.
November 7, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27778037/direct-modulation-of-firing-activity-by-dopamine-d2-like-receptors-in-the-globus-pallidus-of-both-normal-and-parkinsonian-rats
#6
Yong-Cun Zhu, Yan Xue, Hui-Ling Diao, Hua Chen, Hong-Yun Liu, Xiao-Hua Han, Lei Chen
The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia circuit, which regulates movement under both normal and pathological conditions. Previous studies have shown that the globus pallidus receives dopaminergic innervation from the axonal collaterals of nigrostriatal fibers. Both dopamine D1 and D2 like receptors are expressed in the globus pallidus. The present study was aimed to investigate the direct in vivo electrophysiological effects of dopamine D2 like receptors in the globus pallidus of both normal and parkinsonian rats...
October 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27751664/the-utilization-of-an-insertable-cardiac-monitor-in-a-child-with-pallid-breath-holding-spells
#7
Shai Tejman-Yarden, Bruria Ben-Zeev, Yuval Goldshmit, Georgia Sarquella-Brugada, Assi Cicurel, Uriel Katz, David Mishali, Michael Glikson
BACKGROUND: Pacing can be a successful treatment for pallid breath-holding spells, primarily in individuals with severe bradycardia. PATIENT DESCRIPTION: We describe an 18-month-old girl experiencing severe pallid breath-holding spells in whom repeated electrocardiographic, Holter, and electroencephalographic monitoring tests were all normal. RESULTS: Using a subcutaneous insertable cardiac monitor, severe bradycardia was detected during one of this girl's episodes...
June 25, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27751649/pallidal-stimulation-in-parkinson-s-patients-with-contraindications-to-subthalamic-target-a-3-years-follow-up
#8
Julien Bonenfant, Sophie Drapier, Jean François Houvenaghel, Florian Naudet, Claire Haegelen, Paul Sauleau, Marc Vérin
INTRODUCTION: Over a 3-year period, we monitored the efficacy and safety of deep-brain stimulation of the globus pallidus pars interna in patients with advanced Parkinson's disease whose cognitive, psychiatric impairment and/or dopa-resistant axial motor signs made them ineligible for surgery targeting the subthalamic nucleus. METHODS: A total of 25 patients were assessed before surgery, 1 year and 3 years after surgery, on the UPDRS and a neuropsychological battery...
October 11, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27733815/gpi-oscillatory-activity-differentiates-tics-from-the-resting-state-voluntary-movements-and-the-unmedicated-parkinsonian-state
#9
Joohi Jimenez-Shahed, Ilknur Telkes, Ashwin Viswanathan, Nuri F Ince
Background: Deep brain stimulation (DBS) is an emerging treatment strategy for severe, medication-refractory Tourette syndrome (TS). Thalamic (Cm-Pf) and pallidal (including globus pallidus interna, GPi) targets have been the most investigated. While the neurophysiological correlates of Parkinson's disease (PD) in the GPi and subthalamic nucleus (STN) are increasingly recognized, these patterns are not well characterized in other disease states. Recent findings indicate that the cross-frequency coupling (CFC) between beta band and high frequency oscillations (HFOs) within the STN in PD patients is pathologic...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27717186/anesthesia-reduces-discharge-rates-in-the-human-pallidum-without-changing-the-discharge-rate-ratio-between-pallidal-segments
#10
Anna Castrioto, Odeya Marmor, Marc Deffains, Dafna Willner, Eduard Linetsky, Hagai Bergman, Zvi Israel, Renana Eitan, David Arkadir
Classical rate models of basal ganglia circuitry associate discharge rate of the globus pallidus external and internal segments (GPe, GPi respectively) solely with dopaminergic state and predict an inverse ratio between the discharge rates of the two pallidal segments. In contrast, the effects of other rate modulators such as general anesthesia (GA) on this ratio have been ignored. To respond to this need, we recorded the neuronal activity in the GPe and GPi in awake and anesthetized human patients with dystonia (57 and 53 trajectories respectively) and in awake patients with Parkinson's disease (PD, 16 trajectories) undergoing deep brain stimulation procedures...
September 26, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27701719/neuroprotective-effects-of-ellagic-acid-in-a-rat-model-of-parkinson-s-disease
#11
Alireza Sarkaki, Yaghoob Farbood, Mojtaba Dolatshahi, Seyed Mohammad Taqhi Mansouri, Ali Khodadadi
Antioxidants have protective effects against free radicals-induced neural damage in Parkinson's disease (PD). We examined the effects of ellagic acid (EA) on locomotion, pallidal local EEG, and its frequency bands' power and also cerebral antioxidant contents in a rat model of PD induced by 6-hydroxidopamine (6-OHDA). 6-OHDA (16 µg/2µ l) was injected into the right medial forebrain bundle (MFB) in MFB-lesioned rat's brain. Sham group received vehicle instead of 6-OHDA. PD-model was confirmed by rotational test using apomorphine injection...
August 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27683881/effects-of-high-frequency-stimulation-of-the-internal-pallidal-segment-on-neuronal-activity-in-the-thalamus-in-parkinsonian-monkeys
#12
Stefan Kammermeier, Damien Pittard, Ikuma Hamada, Thomas Wichmann
Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease. The effects of this intervention on electrical activity patterns in targets of GPi output, specifically in the thalamus, are poorly understood. The experiments described here examined these effects using electrophysiologic recordings in two Rhesus monkeys rendered moderately parkinsonian through treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), after sampling control data in the same animals...
September 28, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27671661/pallidal-spiking-activity-reflects-learning-dynamics-and-predicts-performance
#13
Eitan Schechtman, Maria Imelda Noblejas, Aviv D Mizrahi, Omer Dauber, Hagai Bergman
The basal ganglia (BG) network has been divided into interacting actor and critic components, modulating the probabilities of different state-action combinations through learning. Most models of learning and decision making in the BG focus on the roles of the striatum and its dopaminergic inputs, commonly overlooking the complexities and interactions of BG downstream nuclei. In this study, we aimed to reveal the learning-related activity of the external segment of the globus pallidus (GPe), a downstream structure whose computational role has remained relatively unexplored...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27644555/lung-regeneration-by-fetal-lung-tissue-implantation-in-a-mouse-pulmonary-emphysema-model
#14
Koh Uyama, Shoji Sakiyama, Mitsuteru Yoshida, Koichiro Kenzaki, Hiroaki Toba, Yukikiyo Kawakami, Kazumasa Okumura, Hiromitsu Takizawa, Kazuya Kondo, Akira Tangoku
The mortality and morbidity of chronic obstructive pulmonary disease are high. However, no radical therapy has been developed to date. The purpose of this study was to evaluate whether fetal mouse lung tissue can grow and differentiate in the emphysematous lung. Fetal lung tissue from green fluorescent protein C57BL/6 mice at 16 days' gestation was used as donor material. Twelve-month-old pallid mice were used as recipients. Donor lungs were cut into small pieces and implanted into the recipient left lung by performing thoracotomy under anesthesia...
2016: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/27628208/social-context-differentially-modulates-activity-of-two-interneuron-populations-in-an-avian-basal-ganglia-nucleus
#15
Sarah Cushing Woolley
Basal ganglia circuits are critical for the modulation of motor performance across behavioral states. In zebra finches, a cortical-basal ganglia circuit dedicated to singing is necessary for males adjust their song performance and transition between spontaneous singing, when they are alone ('undirected' song), and a performance state when they sing to a female ('female-directed song'). However, we know little about the role of different basal ganglia cell types in this behavioral transition or the degree to which behavioral context modulates the activity of different neuron classes...
September 14, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27605426/deep-brain-stimulation-and-sleep-wake-functions-in-parkinson-s-disease-a-systematic-review
#16
Lukas Eugster, Panagiotis Bargiotas, Claudio L Bassetti, W M Michael Schuepbach
Sleep-wake disturbances (SWD) are common nonmotor symptoms (NMS) and have a great impact on quality of life of patients with Parkinson's disease (PD). Deep brain stimulation (DBS) is an established treatment in PD. While the beneficial effects of DBS on cardinal PD motor symptoms are indisputable, the data for several NMS, including sleep-wake functions, are limited and often controversial. Our primary objective was to review the literature on the impact of DBS on sleep-wake functions in patients with PD. A systematic review of articles, published in PubMed between January 1st, 2000 and December 31st, 2015 was performed to identify studies addressing the evolution of sleep-wake functions after DBS in patients with PD...
August 7, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27601909/neurobiology-of-hedonic-tone-the-relationship-between-treatment-resistant-depression-attention-deficit-hyperactivity-disorder-and-substance-abuse
#17
REVIEW
Tia Sternat, Martin A Katzman
Anhedonia, defined as the state of reduced ability to experience feelings of pleasure, is one of the hallmarks of depression. Hedonic tone is the trait underlying one's characteristic ability to feel pleasure. Low hedonic tone represents a reduced capacity to experience pleasure, thus increasing the likelihood of experiencing anhedonia. Low hedonic tone has been associated with several psychopathologies, including major depressive disorder (MDD), substance use, and attention-deficit hyperactivity disorder (ADHD)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27591005/bilirubin-induced-neurological-dysfunction-a-clinico-radiological-neurophysiological-correlation-in-30-consecutive-children
#18
Ronald van Toorn, Philip Brink, Johan Smith, Christelle Ackermann, Regan Solomons
The clinical expression of bilirubin-induced neurological dysfunction varies according to severity and location of the disease. Definitions have been proposed to describe different bilirubin-induced neurological dysfunction subtypes. Our objective was to describe the severity and clinico-radiological-neurophysiological correlation in 30 consecutive children with bilirubin-induced neurological dysfunction seen over a period of 5 years. Thirty children exposed to acute neonatal bilirubin encephalopathy were included in the study...
September 2, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27570324/optic-neuropathy-with-delayed-onset-after-trauma-case-report-and-review-of-the-literature
#19
Kai B Kang, Scott Jones, Amjad Ahmad, Heather E Moss
We report a case of a 16 year-old healthy male, who experienced loss of vision in the right eye immediately after getting punched by a fist. His visual acuity improved to 20/20 within hours, and the optic nerve head appeared normal. CT scan of the orbits showed fractures of the right inferior orbital wall and lamina papyracea. The morning after the injury, he awoke with right eye vision decline to count fingers. There was pallid optic nerve swelling. MRI scan of the orbits showed right medial rectus enlargement and no optic canal abnormalities...
2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27567731/longitudinal-t1-relaxation-rate-r1-captures-changes-in-short-term-mn-exposure-in-welders
#20
Mechelle M Lewis, Michael R Flynn, Eun-Young Lee, Scott Van Buren, Eric Van Buren, Guangwei Du, Rebecca C Fry, Amy H Herring, Lan Kong, Richard B Mailman, Xuemei Huang
OBJECTIVES: We demonstrated recently that the T1 relaxation rate (R1) captured short-term Mn exposure in welders with chronic, relatively low exposure levels in a cross-sectional study. In the current study, we used a longitudinal design to examine whether R1 values reflect the short-term dynamics of Mn exposure. METHODS: Twenty-nine welders were evaluated at baseline and 12 months. Occupational questionnaires estimated short-term welding exposure using welding hours in the 90days prior to each study visit (HrsW90)...
December 2016: Neurotoxicology
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