keyword
MENU ▼
Read by QxMD icon Read
search

globus pallidus

keyword
https://www.readbyqxmd.com/read/28548250/evolution-of-deep-gray-matter-volume-across-the-human-lifespan
#1
Karl Narvacan, Sarah Treit, Richard Camicioli, Wayne Martin, Christian Beaulieu
Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross-sectional cohort of 406 subjects aged 5-83 years; (ii) a longitudinal neurodevelopment cohort of 84 subjects scanned twice approximately 4 years apart, aged 5-27 years at first scan; and (iii) a longitudinal aging cohort of 55 subjects scanned twice approximately 3 years apart, aged 46-83 years at first scan...
May 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28534658/dynamic-brain-glucose-metabolism-identifies-anti-correlated-cortical-cerebellar-networks-at-rest
#2
Dardo G Tomasi, Ehsan Shokri-Kojori, Corinde E Wiers, Sunny W Kim, Şukru B Demiral, Elizabeth A Cabrera, Elsa Lindgren, Gregg Miller, Gene-Jack Wang, Nora D Volkow
It remains unclear whether resting state functional magnetic resonance imaging (rfMRI) networks are associated with underlying synchrony in energy demand, as measured by dynamic 2-deoxy-2-[(18)F]fluoroglucose (FDG) positron emission tomography (PET). We measured absolute glucose metabolism, temporal metabolic connectivity (t-MC) and rfMRI patterns in 53 healthy participants at rest. Twenty-two rfMRI networks emerged from group independent component analysis (gICA). In contrast, only two anti-correlated t-MC emerged from FDG-PET time series using gICA or seed-voxel correlations; one included frontal, parietal and temporal cortices, the other included the cerebellum and medial temporal regions...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28526896/signal-intensity-at-unenhanced-t1-weighted-magnetic-resonance-in-the-globus-pallidus-and-dentate-nucleus-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-in-children
#3
Maria Camilla Rossi Espagnet, Bruno Bernardi, Luca Pasquini, Lorenzo Figà-Talamanca, Paolo Tomà, Antonio Napolitano
BACKGROUND: Few studies have been conducted on the relations between T1-weighted signal intensity changes in the pediatric brain following gadolinium-based contrast agent (GBCA) exposure. OBJECTIVE: The purpose of this study is to investigate the effect of multiple administrations of a macrocyclic GBCA on signal intensity in the globus pallidus and dentate nucleus of the pediatric brain on unenhanced T1-weighted MR images. MATERIALS AND METHODS: This retrospective study included 50 patients, mean age: 8 years (standard deviation: 4...
May 19, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28526642/-asleep-deep-brain-stimulation-surgery-a-critical-review-of-the-literature
#4
REVIEW
Tsinsue Chen, Zaman Mirzadeh, Francisco A Ponce
OBJECTIVE: Although performing deep brain stimulation (DBS) with the patient under general anesthesia without microelectrode recording (MER) or intraoperative test stimulation (ITS) for movement disorders ("asleep" DBS) has become increasingly popular, its feasibility is based on the untested assumption that stereotactic accuracy correlates with positive clinical outcomes. To investigate outcomes after asleep DBS without MER or neurophysiological testing, we reviewed the medical literature on the topic...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28521141/indirect-pathway-of-caudal-basal-ganglia-for-rejection-of-valueless-visual-objects
#5
Hyoung F Kim, Hidetoshi Amita, Okihide Hikosaka
The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe)...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28516323/diffusion-tensor-imaging-findings-of-the-brainstem-in-subjects-with-tonsillar-ectopia
#6
Serpil Kurtcan, Alpay Alkan, Huseyin Yetis, Umit Tuzun, Ayse Aralasmak, Huseyin Toprak, Huseyin Ozdemir
We aimed to evaluate the differences between apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) values obtained from different cranial sites in subjects with Chiari I Malformation (CM-I) and borderline tonsillar ectopia (BTE), and to determine correlations between diffusion tensor imaging (DTI) metrics and the severity of tonsillar ectopia. A total of 73 subjects with CM-I and BTE and 35 control underwent MRI and DTI. In our study, ADC values measured from the level of medulla oblongata and the RD values measured in middle cerebellar peduncles, thalamus, and globus pallidus were higher in CM-I patients than in controls...
May 17, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28515413/magnetic-susceptibility-changes-in-the-basal-ganglia-and-brain-stem-of-patients-with-wilson-s-disease-evaluation-with-quantitative-susceptibility-mapping
#7
Selim Doganay, Kazim Gumus, Gonca Koc, Ayse Kacar Bayram, Mehmet Sait Dogan, Duran Arslan, Hakan Gumus, Sureyya Burcu Gorkem, Saliha Ciraci, Halil Ibrahim Serin, Abdulhakim Coskun
OBJECTIVES: Wilson's disease (WD) is characterized with the accumulation of copper in the liver and brain. The objective of this study is to quantitatively measure the susceptibility changes of basal ganglia and brain stem of pediatric patients with neurological WD using quantitative susceptibility mapping (QSM) in comparison to healthy controls. METHODS: Eleven patients with neurological WD (mean age 15 ± 3.3 years, range 10-22 years) and 14 age-matched controls were prospectively recruited...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28511261/current-practice-and-the-future-of-deep-brain-stimulation-therapy-in-parkinson-s-disease
#8
Leonardo Almeida, Wissam Deeb, Chauncey Spears, Enrico Opri, Rene Molina, Daniel Martinez-Ramirez, Aysegul Gunduz, Christopher W Hess, Michael S Okun
Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual's risk-benefit profile...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28511125/the-many-facets-of-motor-learning-and-their-relevance-for-parkinson-s-disease
#9
REVIEW
Lucio Marinelli, Angelo Quartarone, Mark Hallett, Giuseppe Frazzitta, Maria Felice Ghilardi
The final goal of motor learning, a complex process that includes both implicit and explicit (or declarative) components, is the optimization and automatization of motor skills. Motor learning involves different neural networks and neurotransmitters systems depending on the type of task and on the stage of learning. After the first phase of acquisition, a motor skill goes through consolidation (i.e., becoming resistant to interference) and retention, processes in which sleep and long-term potentiation seem to play important roles...
April 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28509815/serum-iron-concentration-is-associated-with-subcortical-deep-gray-matter-iron-levels-in-multiple-sclerosis-patients
#10
Niels Bergsland, Simone Agostini, Maria M Laganà, Roberta Mancuso, Laura Mendozzi, Eleonora Tavazzi, Pietro Cecconi, Mario Clerici, Francesca Baglio
Iron deposition has been noted widely in the subcortical deep gray matter (SDGM) of multiple sclerosis (MS) patients. Recent evidence suggests that serum iron may cross the blood-brain barrier and might be associated with SDGM iron deposition. The aim of the current study was to assess whether an iron-sensitive MRI measure is related to serum iron concentrations. This was a retrospective, cross-sectional study of 22 MS patients and 24 healthy controls (HCs), group matched for age and sex. Participants were imaged on a 1...
May 15, 2017: Neuroreport
https://www.readbyqxmd.com/read/28495943/retention-of-gadolinium-based-contrast-agents-in-multiple-sclerosis-retrospective-analysis-of-an-18-year-longitudinal-study
#11
Y Forslin, S Shams, F Hashim, P Aspelin, G Bergendal, J Martola, S Fredrikson, M Kristoffersen-Wiberg, T Granberg
BACKGROUND AND PURPOSE: Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and globus pallidus and any associations with cognitive function in multiple sclerosis. MATERIALS AND METHODS: The Signal Intensity Index in the dentate nucleus and globus pallidus was retrospectively evaluated on T1-weighted MR imaging in an 18-year longitudinal cohort study of 23 patients with MS receiving multiple gadolinium-based contrast agent administrations and 23 healthy age- and sex-matched controls...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28491942/a-dataset-of-multi-contrast-population-averaged-brain-mri-atlases-of-a-parkinson-s-disease-cohort
#12
Yiming Xiao, Vladimir Fonov, M Mallar Chakravarty, Silvain Beriault, Fahd Al Subaie, Abbas Sadikot, G Bruce Pike, Gilles Bertrand, D Louis Collins
Parkinson׳s disease (PD) is a neurodegenerative disease that primarily affects the motor functions of the patients. Research and surgical treatment of PD (e.g., deep brain stimulation) often require human brain atlases for structural identification or as references for anatomical normalization. However, two pitfalls exist for many current atlases used for PD. First, most atlases do not represent the disease-specific anatomy as they are based on healthy young subjects. Second, subcortical structures, such as the subthalamic nucleus (STN) used in deep brain stimulation procedures, are often not well visualized...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28488071/erratum-to-correlation-of-electrode-position-and-clinical-outcomes-in-globus-pallidus-stimulation-for-dystonia
#13
Hye Ran Park, Jae Min Lee, Gwanhee Ehm, Hui-Jun Yang, In Ho Song, Yong Hoon Lim, Mi-Ryoung Kim, Keyoung Ran Kim, Woong-Woo Lee, Young Eun Kim, Jae Ha Hwang, Chae Won Shin, Hyeyoung Park, Jin Wook Kim, Han-Joon Kim, Cheolyoung Kim, Dong Gyu Kim, Beom Seok Jeon, Sun Ha Paek
No abstract text is available yet for this article.
May 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28482185/effect-of-exposure-to-polycyclic-aromatic-hydrocarbons-on-basal-ganglia-and-attention-deficit-hyperactivity-disorder-symptoms-in-primary-school-children
#14
Marion Mortamais, Jesus Pujol, Barend L van Drooge, Didac Macià, Gerard Martínez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been proposed as environmental risk factors for attention deficit hyperactivity disorder (ADHD). The effects of these pollutants on brain structures potentially involved in the pathophysiology of ADHD are unknown. OBJECTIVE: The aim of this study was to investigate the effects of PAHs on basal ganglia volumes and ADHD symptoms in school children. METHODS: We conducted an imaging study in 242 children aged 8-12years, recruited through a set of representative schools of the city of Barcelona, Spain...
May 5, 2017: Environment International
https://www.readbyqxmd.com/read/28481350/cell-specific-pallidal-intervention-induces-long-lasting-motor-recovery-in-dopamine-depleted-mice
#15
Kevin J Mastro, Kevin T Zitelli, Amanda M Willard, Kimberly H Leblanc, Alexxai V Kravitz, Aryn H Gittis
The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has remained an untapped resource for therapeutic interventions. Here we demonstrate that optogenetic interventions that dissociate the activity of two neuronal populations in the GPe, elevating the activity of parvalbumin (PV)-expressing GPe neurons over that of Lim homeobox 6 (Lhx6)-expressing GPe neurons, restores movement in dopamine-depleted mice and attenuates pathological activity of basal ganglia output neurons for hours beyond stimulation...
June 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28479586/comparison-of-pallidal-and-subthalamic-deep-brain-stimulation-in-parkinson-s-disease-therapeutic-and-adverse-effects
#16
Ho-Sung Ryu, Mi-Sun Kim, Sooyeoun You, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Kiju Kim, Sun Ju Chung
OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD). METHODS: We retrospectively analyzed the clinical data of patients with PD who underwent GPi (n = 14) or STN (n = 28) DBS surgery between April 2002 and May 2014. The subjects were matched for age at surgery and disease duration. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and levodopa equivalent dose (LED) at baseline and 12 months after surgery were used to assess the therapeutic effects of DBS...
May 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28469157/brain-iron-chelation-by-deferiprone-in-a-phase-2-randomised-double-blinded-placebo-controlled-clinical-trial-in-parkinson-s-disease
#17
Antonio Martin-Bastida, Roberta J Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R Crichton, David T Dexter
Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomology. In a randomised double-blind, placebo controlled trial, 22 early onset PD patients, were administered deferiprone, 10 or 15 mg/kg BID or placebo, for 6 months. Patients were evaluated for PD severity, cognitive function, depression rating and quality of life...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28468999/ketamine-induced-converged-synchronous-gamma-oscillations-in-the-cortico-basal-ganglia-network-of-non-human-primates
#18
Maya Slovik, Boris Rosin, Shay Moshel, Rea Mitelman, Eitan Schechtman, Renana Eitan, Aeyal Raz, Hagai Bergman
NMDA (N-methyl-D-aspartate) antagonists are widely used in anesthesia, pain management, schizophrenia animal model studies and recently as potential antidepressants. However the mechanisms underlying their anesthetic, psychotic, cognitive and emotional effects are still elusive. The basal-ganglia (BG) integrate input from different cortical domains through its dopamine modulated connections, to achieve optimal behavior control. NMDA antagonists have been shown to induce gamma oscillations in human EEG recordings and in rodents cortical and BG networks...
May 3, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28464331/does-deep-brain-stimulation-improve-lower-urinary-tract-symptoms-in-parkinson-s-disease
#19
Lambertus P Witte, Vincent J J Odekerken, Judith A Boel, P Richard Schuurman, Lara C Gerbrandy-Schreuders, Rob M A de Bie
AIMS: To investigate whether deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) or the subthalamic nucleus (STN) improve lower urinary tract symptoms (LUTS) in advanced Parkinson's disease (PD). METHODS: An exploratory post-hoc analysis was performed of specific LUTS items of questionnaires used in a randomized clinical trial with 128 patients (NSTAPS study). First, we compared scores on LUTS items at baseline and 12 months for the GPi DBS and STN DBS group separately...
May 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28458083/cognitive-performance-is-associated-with-gray-matter-decline-in-first-episode-psychosis
#20
Kara Dempster, Ross Norman, Jean Théberge, Maria Densmore, Betsy Schaefer, Peter Williamson
Progressive loss of gray matter has been demonstrated over the early course of schizophrenia. Identification of an association between cognition and gray matter may lead to development of early interventions directed at preserving gray matter volume and cognitive ability. The present study evaluated the association between gray matter using voxel-based morphometry (VBM) and cognitive testing in a sample of 16 patients with first-episode psychosis. A simple regression was applied to investigate the association between gray matter at baseline and 80 months and cognitive tests at baseline...
April 25, 2017: Psychiatry Research
keyword
keyword
101485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"