keyword
MENU ▼
Read by QxMD icon Read
search

Melanocyte stimulating hormone

keyword
https://www.readbyqxmd.com/read/29772029/prolyl-carboxypeptidase-activity-in-the-circulation-and-its-correlation-with-body-weight-and-adipose-tissue-in-lean-and-obese-subjects
#1
Kaat Kehoe, Heidi Noels, Wendy Theelen, Emilie De Hert, Shenguan Xu, An Verrijken, Thierry Arnould, Erik Fransen, Nina Hermans, Anne-Marie Lambeir, Per Venge, Luc Van Gaal, Ingrid De Meester
BACKGROUND: Prolyl carboxypeptidase (PRCP) is involved in the regulation of body weight, likely by hydrolysing alpha-melanocyte-stimulating hormone and apelin in the hypothalamus and in the periphery. A link between PRCP protein concentrations in plasma and metabolic disorders has been reported. In this study, we investigated the distribution of circulating PRCP activity and assessed its relation with body weight and adipose tissue in obese patients and patients who significantly lost weight...
2018: PloS One
https://www.readbyqxmd.com/read/29744907/depigmentation-efficacy-of-galacturonic-acid-through-tyrosinase-regulation-in-b16-murine-melanoma-cells-and-a-three-dimensional-human-skin-equivalent
#2
C S Lee, H S Baek, I-H Bae, S J Choi, Y J Kim, J H Lee, J W Kim
Sugar is a well-known cosmetic ingredient for moisturizing skin with minimal side-effects. Several reports have demonstrated an antimelanogenic effect of sugar in melanocytes. We evaluated the whitening efficacy of galacturonic acid (GA), the main component of pectin, as an anti-melanogenic agent. GA significantly suppressed melanin synthesis and secretion in a concentration-dependent manner in α-melanocyte stimulating hormone-treated B16 melanoma cells, and inhibited tyrosinase activity and expression at a dose of 10 mmol/L...
May 9, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29742429/diet-induced-growth-is-regulated-via-acquired-leptin-resistance-and-engages-a-pomc-somatostatin-growth-hormone-circuit
#3
Heiko Löhr, Simon Hess, Mafalda M A Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M Wunderlich, Peter Kloppenburg, Jens C Brüning, Matthias Hammerschmidt
Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species. However, the mechanisms of melanocortin-dependent growth control still remain ill-defined. Here, we reveal a thus-far-unrecognized structural and functional connection between Pomc neurons and the somatotropic hypothalamo-pituitary axis. Excessive feeding of larval zebrafish causes leptin resistance and reduced levels of the hypothalamic satiety mediator pomca...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29735364/methyl-2-acetylamino-3-4-hydroxyl-3-5-dimethoxybenzoylthio-propanoate-suppresses-melanogenesis-through-erk-signaling-pathway-mediated-mitf-proteasomal-degradation
#4
Ji Hoon Ha, Yoon Ju Jeong, Song Hua Xuan, Jae-Young Lee, Jino Park, Soo Nam Park
BACKGROUND: Microphthalmia-associated transcription factor (MITF) is regulated by expression and/or degradation pathway, controlling to the expression of melanogenic enzymes for melanin synthesis. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate (MAHDP) is reported to anti-melanogenesis effect but its mechanism remain unclear. OBJECTIVE: To investigate the effects of MAHDP on melanogenesis and elucidate its mechanism. METHODS: Tyrosinase activity, melanogenic proteins and gene expression levels were measured with MAHDP treatment in B16F1 cells, human melanocytes, reconstructed skin and clinical trial...
April 22, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29724298/inhibitory-effect-of-berberine-from-coptidis-rhizoma-on-melanin-synthesis-of-murine-malignant-melanoma
#5
Yonghwa Lee, Lichao Liu, Yongsub Yi
Berberine has abundant beneficial properties including anti-cancer effects. In the present study, we examined the inhibitory effect of berberine on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in B16F1 melanoma cells. The results showed that berberine decreased the expression of tyrosinase and microphthalmia-associated transcription factor (MITF) in a dose-dependent manner. In order to observe the potential target for the inhibitory effect of berberine, we examined the effect of berberine on TRP-1 and TRP-2...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29714486/melanoma-imaging-using-18-f-labeled-%C3%AE-melanocyte-stimulating-hormone-derivatives-with-positron-emission-tomography
#6
Chengcheng Zhang, Zhengxing Zhang, Kuo-Shyan Lin, Joseph Lau, Jutta Zeisler, Nadine Colpo, David M Perrin, Francois Benard
Melanocortin 1 receptor (MC1R) is specifically expressed in the majority of melanomas, a leading cause of death related to skin cancers. Accurate staging and early detection is crucial in managing melanoma. Based on the α-melanocyte-stimulating hormone (αMSH) sequence, MC1R-targeted peptides have been studied for melanoma imaging, predominately for use with single-photon emission computed tomography (SPECT), with few attempts made for positron emission tomography (PET). 18 F is a commonly used PET isotope due to readily available cyclotron production, pure positron emission and a favorable half-life (109...
May 1, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29709914/mansonone-e-from-mansonia-gagei-inhibited-%C3%AE-msh-induced-melanogenesis-in-b16-cells-by-inhibiting-creb-expression-and-phosphorylation-in-the-pi3k-akt-pathway
#7
Atsuyoshi Nishina, Airi Miura, Masaharu Goto, Kahori Terakado, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, Hiroyasu Sato, Nyunt Phay
Many natural products that inhibit melanogenesis, freckles, and hyperpigmentation have been selectively used in cosmetics because melanogenesis is linked to the multiple biogenesis cascades of melanin synthesis. However, some of these compounds have side effects that may result in their restriction in the future. We report here the isolation and structural elucidation of compounds extracted from Mansonia gagei and evaluate their activity on melanogenesis inhibition. We isolated five known compounds from M. gagei and identified them as mansonone E (1), mansorin I (2), populene F (3), mansonone G (4), and mansorin B (5)...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670146/crocodiles-alter-skin-color-in-response-to-environmental-color-conditions
#8
Mark Merchant, Amber Hale, Jen Brueggen, Curt Harbsmeier, Colette Adams
Many species alter skin color to varying degrees and by different mechanisms. Here, we show that some crocodylians modify skin coloration in response to changing light and environmental conditions. Within the Family, Crocodylidae, all members of the genus Crocodylus lightened substantially when transitioned from dark enclosure to white enclosures, whereas Mecistops and Osteolaemus showed little/no change. The two members of the Family Gavialidae showed an opposite response, lightening under darker conditions, while all member of the Family Alligatoridae showed no changes...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660504/idh2-deficiency-accelerates-skin-pigmentation-in-mice-via-enhancing-melanogenesis
#9
Jung Hyun Park, Hyeong Jun Ku, Jin Hyup Lee, Jeen-Woo Park
Melanogenesis is a complex biosynthetic pathway regulated by multiple agents, which are involved in the production, transport, and release of melanin. Melanin has diverse roles, including determination of visible skin color and photoprotection. Studies indicate that melanin synthesis is tightly linked to the interaction between melanocytes and keratinocytes. α-melanocyte-stimulating hormone (α-MSH) is known as a trigger that enhances melanin biosynthesis in melanocytes through paracrine effects. Accumulated reactive oxygen species (ROS) in skin affects both keratinocytes and melanocytes by causing DNA damage, which eventually leads to the stimulation of α-MSH production...
April 6, 2018: Redox Biology
https://www.readbyqxmd.com/read/29659163/synthesis-characterization-and-initial-biological-evaluation-of-99mtc-tc-tricarbonyl-labeled-dpa-%C3%AE-msh-peptide-derivatives-for-potential-melanoma-imaging
#10
Feng Gao, Wiebke Sihver, Ralf Bergmann, Birgit Belter, Cristina Bolzati, Nicola Salvarese, Jörg Steinbach, Jens Pietzsch, Hans-Jürgen Pietzsch
α-Melanocyte stimulating hormone (α-MSH) derivatives target the melanocortin-1 receptor (MC1R) specifically and selectively. In this study, the α-MSH derived peptide NAP-NS1 (Nle-Asp-His-D-Phe-Arg-Trp-Gly-NH2) with and without linkers was conjugated with 5-(bis(pyridin-2-yl)methyl)amino)pentanoic acid (DPA-COOH) and labeled with [99mTc]Tc-tricarbonyl by two methods. With the one-pot method the labeling was faster than with the two-pots method, however obtaining similarly high yields. Negligible transchelation and high stability in physiological solutions was determined for the [99mTc]Tc-tricarbonyl-peptide conjugates...
April 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29649791/the-long-term-impact-of-high-levels-of-alpha-melanocyte-stimulating-hormone-in-energy-balance-among-obese-adolescents
#11
Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Yasmin Alaby Martins Ferreira, Patrícia Leão Silva, Aline de Piano Ganen, Lila Missae Oyama, Lian Tock, Marco Túlio de Mello, Sérgio Tufik, Ana Raimunda Dâmaso
BACKGROUND: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents...
April 12, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29642438/sesamol-inhibited-melanogenesis-by-regulating-melanin-related-signal-transduction-in-b16f10-cells
#12
Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. However, overproduction of melanin, in addition to altering the appearance of skin, may lead to skin disorders such as melasma, solar lentigo, and postinflammatory hyperpigmentation...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29614034/novel-1-e-3-e-5-e-1-6-bis-substituted-phenyl-hexa-1-3-5-triene-analogs-inhibit-melanogenesis-in-b16f10-cells-and-zebrafish
#13
Jisun Oh, Jungeun Kim, Jin Ho Jang, Sangwoo Lee, Chul Min Park, Woo-Keun Kim, Jong-Sang Kim
The present study aimed to evaluate the anti-melanogenic activity of 1,6-diphenyl-1,3,5-hexatriene and its derivatives in B16F10 murine melanoma cells and zebrafish embryos. Twenty five (1 E ,3 E ,5 E )-1,6- bis (substituted phenyl)hexa-1,3,5-triene analogs were synthesized and their non-cytotoxic effects were predictively analyzed using three-dimensional quantitative structure-activity relationship approach. Inhibitory activities of these synthetic compounds against melanin synthesis were determined by evaluating melanin content and melanogenic regulatory enzyme expression in B16F10 cells...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29609010/artemisia-asiatica-ethanol-extract-exhibits-anti-photoaging-activity
#14
Deok Jeong, Jongsung Lee, Seong-Gu Jeong, Yo Han Hong, Sulgi Yoo, Sang Yun Han, Ji Hye Kim, Sunggyu Kim, Jin Sic Kim, Young Soo Chung, Jong-Hoon Kim, Young-Su Yi, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia asiatica Nakai is a traditional herbal plant that has long been used in anti-inflammatory, anti-infective and skin protective remedies. AIM OF THE STUDY: In this study, traditionally known skin-protective activity of Artemisia asiatica Nakai was examined with its ethanol extract (Aa-EE) under various photoaging conditions using skin-originated cells, and the underlying mechanism was also examined using various types of cells...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29599718/re-evaluation-of-adrenocorticotropic-hormone-and-melanocyte-stimulating-hormone-activation-of-gpr139-in-vitro
#15
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq -coupling. The in vitro affinity and potency values of L-Trp and L-Phe are within the physiological concentration ranges of L-Trp and L-Phe. A recent paper suggests that adrenocorticotropic hormone (ACTH), α and β melanocyte stimulating hormones (α-MSH and β-MSH) and derivatives α-MSH1-9 /α-MSH1-10 can also activate GPR139 in vitro ...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29577284/regulation-of-eye-and-jaw-colouration-in-three-spined-stickleback-gasterosteus-aculeatus
#16
L Franco-Belussi, C De Oliveira, H N Sköld
Fish can change their skin and eye colour for background matching and signalling. Males of Gasterosteus aculeatus develop ornamental blue eyes and a red jaw during the reproductive season, colours that are further enhanced during courtship. Here, the effects of different hormones on physiological colour changes in the eyes and jaws of male and female G. aculeatus were investigated in vitro. In an in vivo experiment, G. aculeatus were injected with a receptor blocker of a pivotal hormone (noradrenaline) that controls colour change...
March 25, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29574148/%C3%AE-melanocyte-stimulating-hormone-promotes-bone-resorption-resulting-from-increased-osteoblastic-and-osteoclastic-activities-in-goldfish
#17
Hidenori Ishizu, Toshio Sekiguchi, Takahiro Ikari, Kei-Ichiro Kitamura, Yoichiro Kitani, Masato Endo, Makoto Urata, Yasuko Kinoshita, Atsuhiko Hattori, Ajai K Srivastav, Hiroyuki Mishima, Kanta Mizusawa, Akiyoshi Takahashi, Nobuo Suzuki
We examined the effects of α -melanocyte-stimulating hormone (α -MSH) on bone metabolism using regenerating goldfish scales. Normally developed scales on the bodies of goldfish were removed to allow the regeneration of scales under anesthesia. Thereafter, the influence of α -MSH on the regeneration of goldfish scales was investigated in vivo. In brief, α -MSH was injected at a low dose (0.1 μg/g body weight) or a high dose (1μg/g body weight) into goldfish every other day. Ten days after removing the scales, we collected regenerating scales and analyzed osteoblastic and osteoclastic activities as respective marker enzyme (alkaline phosphatase for osteoblasts, tartrate-resistant acid phosphatase for osteoclasts) activity in the regenerating scales as well as plasma calcium levels...
March 21, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29556371/%C3%AE-viniferin-improves-facial-hyperpigmentation-via-accelerating-feedback-termination-of-camp-pka-signaled-phosphorylation-circuit-in-facultative-melanogenesis
#18
Cheong-Yong Yun, Seon Mi Ko, Yong Pyo Choi, Beom Joon Kim, Jungno Lee, Jae Mun Kim, Ju Yeon Kim, Jin Yong Song, Song-Hee Kim, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim
Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica . Methods: We used cAMP-elevated melanocyte cultures or facial hyperpigmented patches for pigmentation assays, and applied immunoprecipitation, immunobloting, RT-PCR or reporter gene for elucidation of the antimelanogenic mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29526485/melanogenesis-inhibitory-pregnane-glycosides-from-cynanchum-atratum
#19
Qinghao Jin, Xiang Hua Han, Cheong-Yong Yun, Chul Lee, Jin Woo Lee, Dongho Lee, Mi Kyeong Lee, Sang-Hun Jung, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang
Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dose-dependently inhibited the melanin production with the IC50 values ranging from 4 μM to 33 μM...
April 15, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29521165/a-novel-synthetic-compound-z-5-3-hydroxy-4-methoxybenzylidene-2-iminothiazolidin-4-one-mhy773-inhibits-mushroom-tyrosinase
#20
Hee Jin Jung, Min Jung Lee, Yeo Jin Park, Sang Gyun Noh, A Kyoung Lee, Kyoung Mi Moon, Eun Kyeong Lee, Eun Jin Bang, Yun Jung Park, Su Jeong Kim, Jungho Yang, Sultan Ullah, Pusoon Chun, Young Suk Jung, Hyung Ryong Moon, Hae Young Chung
As part of continued efforts for the development of new tyrosinase inhibitors, (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-one derivatives (1a - 1l) were rationally synthesized and evaluated for their inhibitory potential in vitro. These compounds were designed and synthesized based on the structural attributes of a β-phenyl-α,β-unsaturated carbonyl scaffold template. Among these compounds, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-iminothiazolidin-4-one (1e, MHY773) exhibited the greatest tyrosinase inhibition (IC50 = 2...
March 9, 2018: Bioscience, Biotechnology, and Biochemistry
keyword
keyword
101482
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"