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Melanocyte stimulating hormone

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https://www.readbyqxmd.com/read/28524047/oestrogen-and-progesterone-receptor-in-melanoma-and-nevi-an-immunohistochemical-study
#1
Emi Dika, Pier Alessandro Fanti, Sabina Vaccari, Elisa Capizzi, Alessio Degiovanni, Agnese Gobbi, Bianca Maria Piraccini, Simone Ribero, Carlotta Baraldi, Giulia Maria Ravaioli, Michelangelo Fiorentino, Annalisa Patrizi
The effect of hormonal stimulation and fertility treatments, as well as their role in the development of malignant melanoma (MM), is still to be determined. The aim of this study was to investigate the presence of oestrogen receptor alpha (ERα) and progesterone receptor (PR) in MM and nevi after hormonal stimulation. Immunohistochemical analyses were performed utilizing antibodies specifically directed against ERα and PR in MM and atypical nevi specimens from patients: (1) diagnosed during pregnancy, (2) diagnosed in the six months following delivery, or (3) who had undergone repetitive cycles of hormonal stimulation for in vitro fertilization in the year that preceded MM diagnosis...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28516731/alopecia-areata-hyperactivity-of-the-hypothalamic-pituitary-adrenal-axis-is-a-myth
#2
Beata Bergler-Czop, Bartosz Miziołek, Ligia Brzezińska-Wcisło
INTRODUCTION: Psychological stress is known to cause exacerbation of different skin pathologies including alopecia areata (AA). A hyperactivity of the HPA axis in patients affected by AA (AA-patients) was proposed to be a neuroendocrine response to stress. Still little is known about MSH and cortisol production in AA settings. AIM: The aim of the study was to compare trends in a production of melanocyte-stimulating hormone (MSH) and cortisol in patients with AA-patients and healthy controls...
May 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28514752/%C3%AE-msh-inhibits-adipose-inflammation-via-reducing-foxos-transcription-and-blocking-akt-jnk-pathway-in-mice
#3
Guannv Liu, Meihang Li, Muhammad Saeed, Yatao Xu, Qian Ren, Chao Sun
Alpha melanocyte stimulating hormone (αMSH) abates inflammation in multiple tissues, while Forkhead box proteins O (FoxOs) stimulate inflammatory cascade. However, the relationship between αMSH and FoxOs in adipose inflammation remains unclear. In this study, we used LPS-induced inflammation model, attempted to interpret the function of αMSH in inflammation and the interactions with FoxOs. Results indicated that upon inflammatory situation, the secretion of αMSH and the expression of its receptor MC5R were greatly decreased, but FoxOs expressions were elevated...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28505073/anti-pigmentary-effect-of-4-hydroxysattabacin-from-the-marine-derived-bacterium-bacillus-sp
#4
Kyuri Kim, Alain S Leutou, Haein Jeong, Dayoung Kim, Chi Nam Seong, Sang-Jip Nam, Kyung-Min Lim
Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT-PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected...
May 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28495448/nrf2-in-keratinocytes-modulates-uvb-induced-dna-damage-and-apoptosis-in-melanocytes-through-mapk-signaling
#5
Saowanee Jeayeng, Adisak Wongkajornsilp, Andrzej T Slominski, Siwanon Jirawatnotai, Somponnat Sampattavanich, Uraiwan Panich
Responses of melanocytes (MC) to ultraviolet (UV) irradiation can be influenced by their neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine effects of KC on UVB-induced MC responses through phosphorylation of MAPKs in association with oxidative stress in primary human MC cocultured with primary human KC using a transwell co-culture system and small-interfering RNA-mediated silencing of Nrf2 (siNrf2). The mechanisms by which Nrf2 modulated paracrine factors including α-melanocyte-stimulating hormone (α-MSH) and paracrine effects of KC on UVB-mediated apoptosis were also assessed...
May 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28494100/paracrine-regulation-of-melanogenesis
#6
REVIEW
X H Yuan, Z H Jin
Melanocytes are generally characterized by the basic ability of melanin synthesis and transfer to adjacent keratinocytes to constitute individual skin phenotype and provide epidermal protection from various stimuli, such as ultraviolet (UV) irradiation, through a complex process called melanogenesis, which can be regulated by autocrine or paracrine factors. Recent evidences have revealed the paracrine effects of keratinocytes on melanogenesis by secreting cytokines, including alpha-melanocyte stimulating hormone (α-MSH) and endothelin-1...
May 11, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28491052/receptor-mediated-melanoma-targeting-with-radiolabeled-%C3%AE-melanocyte-stimulating-hormone-relevance-of-the-net-charge-of-the-ligand
#7
Jean-Philippe Bapst, Alex N Eberle
A majority of melanotic and amelanotic melanomas overexpress melanocortin type 1 receptors (MC1Rs) for α-melanocyte-stimulating hormone. Radiolabeled linear or cyclic analogs of α-MSH have a great potential as diagnostic or therapeutic tools for the management of malignant melanoma. Compounds such as [(111)In]DOTA-NAP-amide exhibit high affinity for the MC1R in vitro, good tumor uptake in vivo, but they may suffer from relatively high kidney uptake and retention in vivo. We have shown previously that the introduction of negative charges into radiolabeled DOTA-NAP-amide peptide analogs may enhance their excretion and reduce kidney retention...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28488417/melanogenesis-inhibitory-and-antioxidant-activities-of-phenolics-from-periploca-forrestii
#8
Cai-Ling Sun, Lei Chen, Jian Xu, Wei Qu, Li Guan, Wen-Yuan Liu, Toshihiro Akihisa, Feng Feng, Jie Zhang
Two new tetrahydrofuran-type lignans, (-)-gentioluteol-9-O-β-D-glucoside (1), (-)-berchemol 9-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (2), along with sixteen known compounds 3-18 were isolated from the 95% EtOH extract of the stems of Periploca forrestii. The structures of new tetrahydrofuran-type lignans were determined by HR-ESI-MS and various NMR techniques in combination with CD method. Then, their antioxidant abilities were evaluated by 1,1-diphenyl-2-picrylhydrazul (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, and ferric-reducing antioxidant power (FRAP) assays...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28473259/the-central-effects-of-alpha-melanocyte-stimulating-hormone-%C3%AE-msh-in-chicks-involve-changes-in-gene-expression-of-neuropeptide-y-and-other-factors-in-distinct-hypothalamic-nuclei
#9
Meghan S Delp, Mark A Cline, Elizabeth R Gilbert
Alpha-melanocyte stimulating hormone (α-MSH) is a satiety-inducing factor in birds and mammals although central mechanisms mediating its effects on appetite in birds are poorly understood. Thus, the objective of the present study was to determine effects of centrally-injected α-MSH on c-Fos and gene expression in chick appetite-associated hypothalamic nuclei. At 4days post-hatch, 3h-fasted chicks were intracerebroventricularly (ICV) injected with 0 (vehicle) or 0.12nmol α-MSH and 1h later, hypothalamus samples were collected for measuring c-Fos immunoreactivity and mRNA abundance of appetite-associated factors in hypothalamic nuclei...
May 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28450851/regulation-of-agouti-related-protein-and-pro-opiomelanocortin-gene-expression-in-the-avian-arcuate-nucleus
#10
REVIEW
Timothy Boswell, Ian C Dunn
The arcuate nucleus is generally conserved across vertebrate taxa in its neuroanatomy and neuropeptide expression. Gene expression of agouti-related protein (AGRP), neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript (CART) has been established in the arcuate nucleus of several bird species and co-localization demonstrated for AGRP and NPY. The proteins encoded by these genes exert comparable effects on food intake in birds after central administration to those seen in other vertebrates, with AGRP and NPY being orexigenic and CART and α-melanocyte-stimulating hormone anorexigenic...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28450348/melanocortin-1-receptor-signaling-regulates-cholesterol-transport-in-macrophages
#11
Petteri Rinne, Martina Rami, Salla L Nuutinen, Donato Santovito, Emiel P C van der Vorst, Raquel Guillamat-Prats, Leo-Pekka Lyytikäinen, Emma Raitoharju, Niku Oksala, Larisa Ring, Minying Cai, Victor J Hruby, Terho J Lehtimäki, Christian Weber, Sabine Steffens
Background -The melanocortin 1 receptor (MC1-R) is expressed by monocytes and macrophages, where it exerts anti-inflammatory actions upon stimulation with its natural ligand α-melanocyte-stimulating hormone (α-MSH). The present study was designed to investigate the specific role of MC1-R in the context of atherosclerosis and possible regulatory pathways of MC1-R beyond anti-inflammation. Methods -Human and mouse atherosclerotic samples and primary mouse macrophages were used to study the regulatory functions of MC1-R...
April 27, 2017: Circulation
https://www.readbyqxmd.com/read/28438719/chick-subcutaneous-and-abdominal-adipose-tissue-depots-respond-differently-in-lipolytic-and-adipogenic-activity-to-%C3%AE-melanocyte-stimulating-hormone-%C3%AE-msh
#12
Steven L Shipp, Guoqing Wang, Mark A Cline, Elizabeth R Gilbert
In birds, α-MSH is anorexigenic, but effects on adipose tissue are unknown. Four day-old chicks were intraperitoneally injected with 0 (vehicle), 5, 10, or 50μg of α-MSH and subcutaneous and abdominal adipose tissue collected at 60min for RNA isolation (n=10). Plasma was collected post-euthanasia at 60 and 180min for measuring non-esterified fatty acids (NEFA) and α-MSH (n=10). Relative to the vehicle, food intake was reduced in the 50μg-treated group. Plasma NEFAs were greater in 10μg than vehicle-treated chicks at 3h...
July 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28434791/neuronal-cells-derived-from-human-induced-pluripotent-stem-cells-as-a-functional-tool-of-melanocortin-system
#13
Nobuko Yamada-Goto, Yukari Ochi, Goro Katsuura, Yui Yamashita, Ken Ebihara, Michio Noguchi, Junji Fujikura, Daisuke Taura, Masakatsu Sone, Kiminori Hosoda, Paul E Gottschall, Kazuwa Nakao
BACKGROUND: The preparation of human neurons derived from human induced pluripotent stem (iPS) cells can serve as a potential tool for evaluating the physiological and pathophysiological properties of human neurons and for drug development. METHODS: In the present study, the functional activity in neuronal cells differentiated from human iPS cells was observed. RESULTS: The differentiated cells expressed mRNAs for classical neuronal markers (microtubule-associated protein 2, β-tubulin III, calbindin 1, synaptophysin and postsynaptic density protein 95) and for subunits of various excitatory and inhibitory transmitters (NR1, NR2A, NR2B, GABAA α1)...
April 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28425165/melanogenesis-inhibitory-and-cytotoxic-activities-of-limonoids-alkaloids-and-phenolic-compounds-from-phellodendron-amurense-bark
#14
Toshihiro Akihisa, Satoru Yokokawa, Eri Ogihara, Masahiro Matsumoto, Jie Zhang, Takashi Kikuchi, Kazuo Koike, Masahiko Abe
Four limonoids, 1-4, five alkaloids, 5-9, and four phenolic compounds, 10-13, were isolated from a MeOH extract of the bark of Phellodendron amurense (Rutaceae). Among these, compound 13 was a new, and its structure was established as rel-(1R,2R,3R)-5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1-(methoxycarbonylmethyl)indane-2-carboxylic acid methyl ester (γ-di(methyl ferulate)) based on the spectrometric analysis. Upon evaluation of compounds 1-13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-N-methyl-2-quiolone (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells...
April 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28398611/regulation-of-mir-21-expression-in-human-melanoma-via-uv-ray-induced-melanin-pigmentation
#15
Kuan-Yu Lin, Chien-Min Chen, Cheng-You Lu, Chun-Yuan Cheng, Yu-Hsin Wu
Excessive environmental ultraviolet (UV) radiation produces genetic mutations that can lead to skin cancer. This study was designed to assess the potential inhibitory activity of microRNA-21 (miR-21) on the UV irradiation-stimulated melanogenesis signal pathway in melanoma cells. The molecular mechanism of miR-21-induced inhibitory activity on UV-ray-stimulated melanogenesis-regulating proteins was examined in A375.S2 human melanoma and B16F10 mouse melanoma cells. UV irradiation for 30 min induced melanogenesis signal pathway by increasing melanin production and the number of A375...
April 11, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28388573/amsh-prevents-ros-induced-apoptosis-by-inhibiting-foxo1-mtorc2-in-mice-adipose-tissue
#16
Weina Cao, Meihang Li, Tianjiao Wu, Fei Feng, Tongying Feng, Yang Xu, Chao Sun
Alpha-melanocyte stimulating hormone (αMSH) is an important adenohypophysis polypeptide hormone that regulates body metabolic status. To date, it is well known that the disorder of hypothalamic αMSH secretion is related to many metabolic diseases, such as obesity and type II diabetes. However, the underlying mechanisms are poorly understood. In our study, we focused on the reactive oxygen species (ROS)-induced adipocyte apoptosis and tried to unveil the role of αMSH in this process and the signal pathway which αMSH acts through...
March 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382155/preclinical-melanoma-imaging-with-68-ga-labeled-%C3%AE-melanocyte-stimulating-hormone-derivatives-using-pet
#17
Chengcheng Zhang, Zhengxing Zhang, Kuo-Shyan Lin, Jinhe Pan, Iulia Dude, Navjit Hundal-Jabal, Nadine Colpo, François Bénard
It is estimated that melanoma accounted for 76,380 new cases and 10,130 deaths in the United States in 2016. The melanocortin 1 receptor (MC1R) is highly expressed in the vast majority of melanomas, which makes it an attractive target for molecular imaging and radionuclide therapy. Lactam bridge-cyclized α-melanocyte-stimulating hormone (Ac-Nle(4)-cyclo[Asp(5)-His-D-Phe(7)-Arg-Trp-Lys(10)]-NH2, or Nle-CycMSHhex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT)...
2017: Theranostics
https://www.readbyqxmd.com/read/28371026/interaction-and-developmental-activation-of-two-neuroendocrine-systems-that-regulate-light-mediated-skin-pigmentation
#18
Gabriel E Bertolesi, Yi Nong Song, Karen Atkinson-Leadbeater, Jung-Lynn Jonathan Yang, Sarah McFarlane
Lower vertebrates use rapid light-regulated changes in skin colour for camouflage (background adaptation) or during circadian variation in irradiance levels. Two neuroendocrine systems, the eye/alpha melanocyte stimulating hormone (α-MSH) and the pineal complex/melatonin circuits, regulate the process through their respective dispersion and aggregation of pigment granules (melanosomes) in skin melanophores. During development, Xenopus laevis tadpoles raised on a black background or in the dark perceive less light sensed by the eye and darken in response to increased α-MSH secretion...
March 30, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28367103/novel-approaches-to-vitiligo-treatment-via-modulation-of-mtor-and-nf-%C3%AE%C2%BAb-pathways-in-human-skin-melanocytes
#19
Jerry Wan, Fuquan Lin, Wei Zhang, Aie Xu, Joseph DeGiorgis, Hongguang Lu, Yinsheng Wan
Vitiligo is a skin depigmentation disorder with an increasing prevalence. Among recognized mechanisms is the oxidative stress that affects melanocytes which are responsible for skin pigmentation. Studies have shown that high concentration of hydrogen peroxide, or H2O2, induces apoptotic activities. Few studies have been done with lower doses of H2O2. Using human skin melanocytes, we investigated the effect of moderate concentration of H2O2 on melanocyte dendrites. Confocal data show that H2O2 at 250 µM induces loss of dendrites, as indicated by cytoskeletal proteins...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28356453/the-melanocortin-system-regulates-body-pigmentation-and-social-behaviour-in-a-colour-polymorphic-cichlid-fish
#20
Peter D Dijkstra, Sean M Maguire, Rayna M Harris, Agosto A Rodriguez, Ross S DeAngelis, Stephanie A Flores, Hans A Hofmann
The melanocortin system is a neuroendocrine system that regulates a range of physiological and behavioural processes. We examined the extent to which the melanocortin system simultaneously regulates colour and behaviour in the cichlid fish Astatotilapia burtoni We found that yellow males are more aggressive than blue males, in line with previous studies. We then found that exogenous α-melanocyte-stimulating hormone (α-MSH) increases yellowness of the body and dispersal of xanthophore pigments in both morphs...
March 29, 2017: Proceedings. Biological Sciences
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