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Melanocyte stimulating hormone

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https://www.readbyqxmd.com/read/29099963/activity-of-the-hypothalamic-melanocortin-system-decreases-in-middle-aged-and-increases-in-old-rats
#1
Nóra Füredi, Alexandra Mikó, Balázs Gaszner, Diána Feller, Ildikó Rostás, Judit Tenk, Margit Solymár, Márta Balaskó, Erika Pétervári
Appearance of middle-aged obesity and aging anorexia both in humans and rodents suggests a role for regulatory alterations. Hypothalamic melanocortin agonist, alpha-melanocyte-stimulating hormone (alpha-MSH) produced in the arcuate nucleus (ARC) reduces body weight via inducing hypermetabolism and anorexia mainly through melanocortin 4 receptors (MC4R) in the paraventricular nucleus (PVN). Orexigenic ARC-derived agouti-related protein (AgRP) is an inverse agonist on MC4R in the PVN. Previously we demonstrated that characteristic age-related shifts in the catabolic effects of alpha-MSH may contribute both to middle-aged obesity and aging anorexia...
November 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29090638/indomethacin-inhibits-melanogenesis-via-down-regulation-of-mitf-mrna-transcription
#2
Kazuomi Sato, Masahiro Takei, Ray Iyota, Yoshimasa Muraoka, Marika Nagashima, Yoshitaka Yoshimura
Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit several divergent biological effects. In this study, we investigated the effect of indomethacin on melanin synthesis using B16F1 melanoma cells. Indomethacin inhibited α-melanocyte stimulating hormone (α-MSH)-enhanced melanin synthesis in a dose-dependent manner. Western blotting analysis revealed that indomethacin significantly suppressed tyrosinase and Mitf protein levels. In a luciferase reporter assay, we found that indomethacin reduced tyrosinase promoter activity...
November 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29058865/melanocortin-1-receptor-targeting-ultrasmall-silica-nanoparticles-for-dual-modality-human-melanoma-imaging
#3
Feng Chen, Xiuli Zhang, Kai Ma, Brian Madajewski, Miriam Benezra, Li Zhang, Evan Phillips, Melik Ziya Turker, Fabio Gallazzi, Michael Overholtzer, Mohan Pauliah, Mithat Gonen, Pat Zanzonico, Ulrich B Wiesner, Michelle S Bradbury, Thomas Quinn
The poor prognosis associated with malignant melanoma has not changed substantially over the past 30 years. Targeted molecular therapies, such as immunotherapy have shown promise, but suffer from resistance and off-target toxicities, underscoring the need for alternative therapeutic strategies that can be used in combination with existing protocols. Moreover, peptides targeting melanoma-specific markers, like the melanocortin-1 receptor (MC1-R), for imaging and therapy exhibit high renal uptake that limits clinical translation...
October 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29056352/does-mch-play-a-role-on-establishment-or-maintenance-of-social-hierarchy-in-nile-tilapia
#4
Guilherme Corrêa Ramanzini, Gilson Luiz Volpato, Maria Aparecida Visconti
Body coloration has a fundamental role in animal communication by signaling sex, age, reproductive behavior, aggression, etc. Nile-tilapia exhibits dominance hierarchy and the dominants are paler than subordinates. During social interactions in these animals, these color changes occur rapidly, and normally the subordinates become dark. In teleosteans, from the great number of hormones and neurotransmitters involved in color changes, melanocyte hormone stimulates (α-MSH) and melanin concentrates hormone (MCH) are the most remarkable...
January 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29044987/sticky-fingers-at-work-palmitoylation-dependent-mc1r-activation
#5
Jose Carlos Garcia-Borron, Celia Jimenez-Cervantes
No abstract text is available yet for this article.
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29042315/il-1%C3%AE-reduces-glua1-phosphorylation-and-its-surface-expression-during-memory-reconsolidation-and-%C3%AE-melanocyte-stimulating-hormone-can-modulate-these-effects
#6
Ivana Machado, Helgi B Schiöth, Mercedes Lasaga, Teresa Scimonelli
Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1β (IL-1β) influences hippocampus-dependent memories. We previously reported that administration of IL-1β in dorsal hippocampus impaired contextual fear memory reconsolidation. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). Our results also demonstrated that IL-1β produced a significant decrease in glutamate release from dorsal hippocampus synaptosomes after reactivation of the fear memory...
October 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29031731/evaluation-of-a-melanocortin-4-receptor-mc4r-agonist-setmelanotide-in-mc4r-deficiency
#7
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L Panaro, Roger D Cone, Karine Clément, I Sadaf Farooqi, Lex H T Van der Ploeg
OBJECTIVE: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese individuals with complete POMC deficiency. While POMC deficiency is very rare, 1-5% of severely obese individuals harbor heterozygous mutations in MC4R. We sought to assess the efficacy of Setmelanotide in human MC4R deficiency. METHODS: We studied the effects of Setmelanotide on mutant MC4Rs in cells and the weight loss response to Setmelanotide administration in rodent studies and a human clinical trial...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29023410/long-term-osmotic-mini-pump-treatment-with-alpha-msh-improves-myocardial-function-in-zucker-diabetic-fatty-rats
#8
Miklos Szokol, Daniel Priksz, Mariann Bombicz, Balazs Varga, Arpad Kovacs, Gabor Aron Fulop, Tamas Csipo, Aniko Posa, Attila Toth, Zoltan Papp, Zoltan Szilvassy, Bela Juhasz
The present investigation evaluates the cardiovascular effects of the anorexigenic mediator alpha-melanocyte stimulating hormone (MSH), in a rat model of type 2 diabetes. Osmotic mini pumps delivering MSH or vehicle, for 6 weeks, were surgically implanted in Zucker Diabetic Fatty (ZDF) rats. Serum parameters, blood pressure, and weight gain were monitored along with oral glucose tolerance (OGTT). Echocardiography was conducted and, following sacrifice, the effects of treatment on ischemia/reperfusion cardiac injury were assessed using the isolated working heart method...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29020973/the-%C3%AE-melanocyte-stimulating-hormone-peroxisome-proliferator-activated-receptor-%C3%AE-pathway-down-regulates-proliferation-in-melanoma-cell-lines
#9
Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo, Vittoria Maresca
BACKGROUND: The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known to enhance melanocyte proliferation. αMSH acts as a mitogenic agent in melanocytes and its effect on proliferation of melanoma cells is less known. We previously identified the αMSH/Peroxisome Proliferator Activated Receptor (PPARγ) pathway as a new pathway on the B16-F10 mouse melanoma cell line...
October 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28993145/an-inhibitory-mechanism-of-action-of-a-novel-syringic-acid-derivative-on-%C3%AE-melanocyte-stimulating-hormone-%C3%AE-msh-induced-melanogenesis
#10
Yoon Ju Jeong, Jae-Young Lee, Jino Park, Soo Nam Park
AIMS: To report the effects of a novel syringic-acid derivative, (R)-ethyl-2-acetamido-3-(4-hydroxy-3,5-dimethoxybenzoylthio)propanoate (EABTO), on melanin synthesis and to identify its mechanism of action in B16F1 melanoma cells. METHODS: The effects of EABTO on melanin synthesis in B16F1 cells and human epidermal melanocytes and the influence on cell-free tyrosinase activity were evaluated. EABTO-induced cellular signaling cascades were studied by western blotting...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28990818/serum-%C3%AE-melanocyte-stimulating-hormone-may-act-as-a-protective-biomarker-for-non-traumatic-osteonecrosis-of-the-femoral-head
#11
Zheng Mao, Gang Liu, Jing-Jie Chen, Dan Liu, Min-Peng Xu, Chang Zhao, Hai-Tao Yang, Yong-Bin Yue
Background The α-melanocyte-stimulating hormone (α-MSH), an endogenous neuropeptide derived from proopiomelanocortin (POMC), has been identified to suppress inflammation and prevent osteoblast damage. Objective The present study was aimed to investigate the role of serum α-MSH in non-traumatic osteonecrosis of the femoral head (ONFH). Methods Seventy-nine patients diagnosed with non-traumatic ONFH and 79 sex- and age-matched healthy controls were enrolled in the study. Serum α-MSH concentrations were examined with a double antibody radioimmunoassay...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28982315/bacterial-protein-mimetic-of-peptide-hormone-as-a-new-class-of-protein-based-drugs
#12
S O Fetissov, Romain Legrand, Nicolas Lucas
Background Specific peptide molecules classified as hormones, neuropeptides and cytokines are involved in intercellular signaling regulating various physiological processes in all organs and tissues. This justifies the peptidergic signaling as an attractive pharmacological target. Recently, a protein mimetic of a peptide hormone has been identified in Escherichia coli suggesting the potential use of specific bacterial proteins as a new type of peptide-like drugs. Objective This paper describes the scientific rational and the technological approach leading to the identification of the E...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28963067/nucb2-nesfatin-1-expression-and-functions-in-the-regulation-of-emotion-and-stress
#13
REVIEW
Yanyan Wei, Jiangbo Li, Huiling Wang, Gaohua Wang
Nesfatin-1, a food-intake inhibiting factor processed from nucleobindin 2 (NUCB2), was originally identified by the Oh-I research group. The initial functional studies on NUCB2/nesfatin-1 were mainly focused on its properties of appetite regulation. As is well known, emotional state has an interactional relationship with food intake, and difficulties in regulating emotion and stress have a great influence on appetite and body weight. Some anorexigenic or orexigenic neurotransmitters also play a role in the adjustment of emotion and stress responses in addition to their actions on the homeostatic regulation of food intake, including neuropeptide Y (NPY), melanocyte stimulating hormone (MSH), corticotropin-releasing factor (CRF), and ghrelin...
September 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28962188/dynamic-changes-of-%C3%AE-melanocyte-stimulating-hormone-levels-in-the-serum-of-patients-with-craniocerebral-trauma
#14
Xiaoguang Du, Baozhong Dong, Chen Li, Faxue Zhang, Yanwei Ji, Jianbin Zhang, Changjiang Yin
The aim of the study was to investigate dynamic changes in α-melanocyte-stimulating hormone (α-MSH) levels in the serum of patients with craniocerebral trauma. Forty-eight patients with acute craniocerebral injury were selected between January 2015 and October 2016. The patients were divided into three groups: severe (18 cases), moderate (16 cases) and mild (14 cases), according to the Glasgow Coma Scale (GCS) score at the time of admission. At the same time, 10 adults with a similar age distribution to the patients were also selected as a control group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28936166/nucleus-accumbens-mc4-r-stimulation-reduces-food-and-ethanol-intake-in-adult-rats-regardless-of-binge-like-ethanol-exposure-during-adolescence
#15
Francisca Carvajal, José M Lerma-Cabrera, Manuel Alcaraz-Iborra, Montserrat Navarro, Todd E Thiele, Inmaculada Cubero
The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol palatability in adult rats. Ethanol exposure during adolescence causes long-lasting changes in neural pathways critically involved in neurobehavioral responses to ethanol. In this regard, binge-like ethanol exposure during adolescence reduces basal alpha-melanocyte-stimulating hormone (α-MSH) and alters the levels of agouti-related peptide (AgRP) in hypothalamic and limbic areas...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28916831/the-melanocortin-signaling-camp-axis-accelerates-repair-and-reduces-mutagenesis-of-platinum-induced-dna-damage
#16
Stuart G Jarrett, Katharine M Carter, Brent J Shelton, John A D'Orazio
Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanced clearance of intrastrand cisplatin-adducts in melanocytes or MC1R-transfected HEK293 cells. MC1R antagonists human beta-defensin 3 and agouti signaling protein blocked MSH- but not forskolin-mediated enhancement of platinum-induced DNA damage...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915638/oleoylethanolamide-inhibits-%C3%AE-melanocyte-stimulating-hormone-stimulated-melanogenesis-via-erk-akt-and-creb-signaling-pathways-in-b16-melanoma-cells
#17
Juan Zhou, Tong Ren, Ying Li, Anran Cheng, Wanyi Xie, Lanxi Xu, Lu Peng, Jinbin Lin, Lianxiang Lian, Yong Diao, Xin Jin, Lichao Yang
The present study aimed to examine the potential inhibitory activity of oleoylethanolamide (OEA) on α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis and the molecular mechanism(s) involved in the process in B16 mouse melanoma cells. Our data demonstrated that OEA markedly inhibited melanin synthesis and tyrosinase activity in α-MSH-stimulated B16 cells. In addition, the expression of melanogenesis-related proteins, such as melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase, was suppressed in a concentration-dependent manner by OEA...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28904020/gtrap3-18-regulates-food-intake-and-body-weight-by-interacting-with-pro-opiomelanocortin
#18
Koji Aoyama, Wattanaporn Bhadhprasit, Masahiko Watabe, Fan Wang, Nobuko Matsumura, Toshio Nakaki
Pro-opiomelanocortin (POMC)-expressing neurons provide α-melanocyte-stimulating hormone (α-MSH), which stimulates melanocortin 4 receptor to induce hypophagia by AMPK inhibition in the hypothalamus. α-MSH is produced by POMC cleavage in secretory granules and released. However, it is not known yet whether any posttranscriptional regulatory mechanism of POMC signaling exists upstream of the secretory granules in neurons. Here we show that glutamate transporter-associated protein 3-18 (GTRAP3-18), an anchor protein that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC...
September 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28899502/melaleuca-quinquenervia-essential-oil-inhibits-%C3%AE-melanocyte-stimulating-hormone-induced-melanin-production-and-oxidative-stress-in-b16-melanoma-cells
#19
Wen-Wan Chao, Chia-Chi Su, Hsin-Yi Peng, Su-Tze Chou
BACKGROUND: Essential oils are odorous, volatile products of plant secondary metabolism, which are found in many leaves and stems. They show important biological activities, which account for the development of aromatherapy used in complementary and alternative medicine. The essential oil extracted from Melaleuca quinquenervia (Cav.) S.T. Blake (paperbark) (MQ-EO) has various functional properties. PURPOSE: The aim of this study is to investigate the chemical composition of MQ-EO by using gas chromatography-mass spectrometry (GC-MS) and evaluate its tyrosinase inhibitory activity...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28884442/whitening-and-anti-wrinkle-activities-of-ferulic-acid-isolated-from-tetragonia-tetragonioides-in-b16f10-melanoma-and-ccd-986sk-fibroblast-cells
#20
Hye-Jin Park, Jun-Hyo Cho, Shin-Hyub Hong, Dong-Hee Kim, Hee-Young Jung, In-Kyu Kang, Young-Je Cho
Ferulic acid isolated from Tetragonia tetragonioides was tested for its whitening effect on the B16F10 mouse melanoma cell line and its anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line. Ferulic acid, one of the primary phenolic compounds that can be isolated from T. tetragonioides, has been reported to show potential as a functional food, for its whitening effect and anti-wrinkle activity. To measure its whitening and anti-wrinkle activities, cells were treated with ferulic acid isolated from T...
September 7, 2017: Journal of Natural Medicines
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