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https://www.readbyqxmd.com/read/28929544/computed-tomographic-appearance-of-canine-tonsillar-neoplasia-14-cases
#1
Florence Thierry, Maurizio Longo, Evi Pecceu, Davide D Zani, Tobias Schwarz
The palatine tonsil is an uncommon site of oral canine neoplasia. For affected tonsils, squamous cell carcinoma is the most frequent type of neoplasia, followed by melanoma and lymphoma. Computed tomography (CT) is increasingly used for investigation of canine oropharyngeal pathology; however, limited information is available on the CT appearance of tonsillar neoplasms. Objectives of this retrospective descriptive case series were to characterize the CT features of canine tonsillar neoplasia and determine whether specific CT features differentiate nonneoplastic from neoplastic tonsils...
September 19, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28735667/immunohistochemical-expression-of-mcam-cd146-in-canine-melanoma
#2
S Abou Asa
MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours...
July 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28720294/papillomaviruses-in-dogs-and-cats
#3
REVIEW
John S Munday, Neroli A Thomson, Jennifer A Luff
Papillomaviruses (PVs) cause disease in both dogs and cats. In dogs, PVs are thought to cause oral papillomatosis, cutaneous papillomas and canine viral pigmented plaques, whereas PVs have been rarely associated with the development of oral and cutaneous squamous cell carcinomas in this species. In cats, PVs are currently thought to cause oral papillomas, feline viral plaques, Bowenoid in situ carcinomas and feline sarcoids. Furthermore, there is increasing evidence that PVs may also be a cause of cutaneous squamous cell carcinomas and basal cell carcinomas in cats...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28715311/animal-models-new-biosensors-and-technologies-including-those-for-bone-regrowth-and-wound-healing-advance-animal-health-care-while-also-providing-a-fertile-testing-ground-for-human-health
#4
Summer Allen
Dogs have bad breath. But when Montana sheep rancher Katy Harjes noticed her collie, Hoshi, had particularly bad breath and facial swelling, she was concerned that the symptoms might be a sign of something serious. She was right; ten-year-old Hoshi had squamous cell carcinoma, a common type of oral tumor found in dogs. The cancer had not metastasized, but the damage was extensive enough that part of Hoshi's lower jaw needed to be removed. Luckily, Hoshi was a suitable candidate for a stateof-the-art bone regrowth procedure developed by Frank Verstraete, B...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/27916918/subchronic-toxicities-of-hz1006-a-hydroxamate-based-histone-deacetylase-inhibitor-in-beagle-dogs-and-sprague-dawley-rats
#5
Xiaofang Zhang, Xiaodong Zhang, Bojun Yuan, Lijun Ren, Tianbao Zhang, Guocai Lu
Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very good toxicity profiles and are currently being tested in phases I and II clinical trials with promising results in selected neoplasms, such as bladder carcinoma. One of the Hb-HDACIs, HZ1006, has been demonstrated to be a promising drug for clinical use. The aim of our study was to determine the possible target of toxicity and to identify a non-toxic dose of HZ1006 for clinical use...
November 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27580113/phase-i-ii-clinical-trial-of-hyaluronan-cisplatin-nanoconjugate-in-dogs-with-naturally-occurring-malignant-tumors
#6
Shuang Cai, Ti Zhang, W C Forrest, Qiuhong Yang, Chad Groer, Eva Mohr, Daniel J Aires, Sandra M Axiak-Bechtel, Brian K Flesner, Carolyn J Henry, Kimberly A Selting, Deborah Tate, Jeffrey A Swarz, Jeffrey N Bryan, M Laird Forrest
OBJECTIVE To conduct a phase I-II clinical trial of hyaluronan-cisplatin nanoconjugate (HA-Pt) in dogs with naturally occurring malignant tumors. ANIMALS 18 healthy rats, 9 healthy mice, and 16 dogs with cancer. PROCEDURES HA-Pt was prepared and tested by inductively coupled plasma mass spectrometry; DNA-platinum adduct formation and antiproliferation effects of cisplatin and HA-Pt were compared in vitro. Effects of cisplatin (IV) and HA-Pt (SC) in rodents were tested by clinicopathologic assays. In the clinical trial, dogs with cancer received 1 to 4 injections of HA-Pt (10 to 30 mg/m(2), intratumoral or peritumoral, q 3 wk)...
September 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27276060/immunohistochemical-analysis-of-pd-l1-expression-in-canine-malignant-cancers-and-pd-1-expression-on-lymphocytes-in-canine-oral-melanoma
#7
Naoya Maekawa, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Ryoyo Ikebuchi, Yusuke Izumi, Satoshi Takagi, Yumiko Kagawa, Chie Nakajima, Yasuhiko Suzuki, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi
Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1) is a costimulatory receptor with immunosuppressive function...
2016: PloS One
https://www.readbyqxmd.com/read/27245341/co-lyophilized-aspirin-with-trehalose-causes-less-injury-to-human-gastric-cells-and-gastric-mucosa-of-rats
#8
Lee-Shuan Lin, Yuko Kayasuga-Kariya, Shugo Nakamura, Nobuyuki Shimohata, Takamasa Sakai, Ayano Fujisawa, Yuki Akagi, Shigeki Suzuki, Ung-Il Chung, Nobuo Sasaki, Manabu Mochizuki
BACKGROUND: Aspirin is one of the most popular NSAIDs worldwide because of its anti-inflammatory and anticoagulant effects, and however, gastrointestinal injury remains a major complication. We previously reported co-lyophilized aspirin/trehalose (Lyo A/T) decreased the aspirin-induced gastric lesions in dogs. AIM: This study investigated the mechanism of gastroprotective effects of trehalose in vitro and in vivo. METHODS: The apoptotic assays were performed in a human gastric carcinoma cell line, which was treated with aspirin, mixed aspirin/trehalose (Mix A/T) or Lyo A/T...
August 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27147111/collision-tumour-of-squamous-cell-carcinoma-and-malignant-melanoma-in-the-oral-cavity-of-a-dog
#9
F Rodríguez, P Castro, G A Ramírez
A 7-year-old, male cocker spaniel was presented with a gingival proliferative lesion in the rostral maxilla and enlargement of the regional lymph node. Morphological and immunohistochemical analysis revealed a collision tumour composed of two malignant populations, epithelial and melanocytic, with metastasis of the neoplastic melanocytes to the regional lymph node. The epithelial component consisted of trabeculae and islands of well-differentiated squamous epithelium immunoreactive to cytokeratins. The melanocytic component had a varying degree of pigmentation of polygonal and spindle-shaped cells, growing in nests or densely packed aggregates and immunolabelled with S100, melanoma-associated antigen (melan A), neuron-specific enolase and vimentin antibodies...
May 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/26986192/atr-101-a-selective-and-potent-inhibitor-of-acyl-coa-acyltransferase-1-induces-apoptosis-in-h295r-adrenocortical-cells-and-in-the-adrenal-cortex-of-dogs
#10
Christopher R LaPensee, Jacqueline E Mann, William E Rainey, Valentina Crudo, Stephen W Hunt, Gary D Hammer
ATR-101 is a novel, oral drug candidate currently in development for the treatment of adrenocortical cancer. ATR-101 is a selective and potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), an enzyme located in the endoplasmic reticulum (ER) membrane that catalyzes esterification of intracellular free cholesterol (FC). We aimed to identify mechanisms by which ATR-101 induces adrenocortical cell death. In H295R human adrenocortical carcinoma cells, ATR-101 decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity...
May 2016: Endocrinology
https://www.readbyqxmd.com/read/26711040/genomic-characterisation-of-canine-papillomavirus-type-17-a-possible-rare-cause-of-canine-oral-squamous-cell-carcinoma
#11
John S Munday, Magda Dunowska, Rebecca E Laurie, Simon Hills
Squamous cell carcinomas (SCCs) are the second most common cancer of the canine oral cavity resulting in significant morbidity and mortality. Recently a dog with multiple oral SCCs that contained a novel papillomavirus (PV) was reported. The aim of the present study was to determine the genome of this novel PV. To do this a short section of PV DNA was amplified from an oral SCC and 'back-to-back' primers were designed. Due to the circular nature of PV DNA, these primers were then used to amplify the remainder of the genome by inverse PCR...
2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/25956344/molecular-and-immunohistochemical-studies-do-not-support-a-role-for-papillomaviruses-in-canine-oral-squamous-cell-carcinoma-development
#12
John S Munday, Adrienne French, Catherine J Harvey
Oral squamous cell carcinomas (OSCCs) are common neoplasms of dogs and are of unknown cause. Whereas papillomaviruses (PVs) are an established cause of human OSCCs, few studies have investigated canine OSCCs for a PV aetiology. In humans, a PV aetiology can be determined by detecting PV DNA and PV-induced increased p16(CDKN2A) protein (p16) within the OSCC. In this study, PCR, using four different primer sets and p16 immunohistochemistry, was used to evaluate 28 canine OSCCs for a possible PV aetiology. None of the primers amplified PV DNA from any of the OSCCs although four neoplasms contained intense p16 immunostaining...
May 2015: Veterinary Journal
https://www.readbyqxmd.com/read/25613043/multiple-oral-carcinomas-associated-with-a-novel-papillomavirus-in-a-dog
#13
John S Munday, Russell S Tucker, Matti Kiupel, Catherine J Harvey
Papillomaviruses (PVs) are well recognized to cause human oral squamous cell carcinomas (SCCs). However, there is currently little evidence that PVs similarly cause oral cancer in dogs. In the present case, a dog developed an invasive SCC and multiple in situ carcinomas within the mouth. Cell changes consistent with PV infection were prominent within the neoplasms and the surrounding gingiva. Immunohistochemical staining revealed PV antigens and intense p16(CDKN2A) protein (p16) immunostaining within the invasive SCC...
March 2015: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/25524719/pcna-and-grade-in-13-canine-oral-squamous-cell-carcinomas-association-with-prognosis
#14
COMPARATIVE STUDY
L A Mestrinho, P Faísca, M C Peleteiro, M M R E Niza
This study evaluated the prognosis factors of age, tumour size, anatomic location, histological grade and proliferating cell nuclear antigen (PCNA) expression in 13 dogs with oral squamous cell carcinoma (OSCC) with bone invasion and without signs of lymph node or distant metastasis. All animals were treated with radical excision performed with at least 1 cm margin, based on computed tomography images. In the 2-year follow-up, median disease-free survival was 138 days for dogs with grade 3 tumours and was not reached for those with grade 2 tumours...
March 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/25488594/characterization-of-the-transmembrane-transport-and-absolute-bioavailability-of-the-hcv-protease-inhibitor-danoprevir
#15
Barbara J Brennan, Agnès Poirier, Sebastian Moreira, Peter N Morcos, Petra Goelzer, Renée Portmann, Jiney Asthappan, Christoph Funk, Patrick F Smith
BACKGROUND AND OBJECTIVES: Understanding transmembrane transport provides a more complete understanding of the pharmacokinetics of a drug and mechanistic explanations for drug-drug interactions. Here, the transmembrane transport of danoprevir (hepatitis C virus protease inhibitor) and the effects of ritonavir and ciclosporin on transmembrane transport of danoprevir were evaluated and clinical pharmacokinetic studies of danoprevir co-administered with/without ritonavir and ciclosporin were conducted...
May 2015: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/25418424/-prognosis-of-canine-oral-gingival-squamous-cell-carcinoma-after-surgical-therapy-a-retrospective-analysis-in-40-patients
#16
S Kühnel, M Kessler
OBJECTIVE: Retrospective analysis of dogs with gingival squamous cell carcinoma (SCC) surgically treated using jaw resection. Material and me- thods: A total of 40 dogs were enrolled in the study. Dogs with incomplete tumour resection or metastases were subjected to adjuvant chemotherapy using carboplatin. Breed, age, tumour localisation, postsurgical complications, survival times and prognostic factors were evaluated. RESULTS: There were no breed predispositions...
2014: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/25401953/a-retrospective-investigation-on-canine-papillomavirus-1-cpv1-in-oral-oncogenesis-reveals-dogs-are-not-a-suitable-animal-model-for-high-risk-hpv-induced-oral-cancer
#17
Ilaria Porcellato, Chiara Brachelente, Gabriella Guelfi, Alice Reginato, Monica Sforna, Laura Bongiovanni, Luca Mechelli
CPV1 (also called COPV) is a papillomavirus responsible for oral papillomatosis in young dogs. The involvement of this viral type in oral oncogenesis has been hypothesized in oral squamous cell carcinomas (SCCs), but has never been investigated in other neoplastic and hyperplastic oral lesions of dogs. Aim of this study was to investigate the presence of CPV1 in different neoplastic and hyperplastic lesions in order to assess its role in canine oral oncogenesis; according to the results obtained, a second aim of the study was to define if the dog can be considered a valid animal model for oral high risk HPV-induced tumors...
2014: PloS One
https://www.readbyqxmd.com/read/25248518/p63-and-e-cadherin-expression-in-canine-oral-squamous-cell-carcinoma
#18
L A Mestrinho, H Pissarra, P B Faísca, M Bragança, M C Peleteiro, M M R E Niza
The expression of p63 and E-cadherin was studied in 22 oral squamous cell carcinomas in the dog according to immunohistochemical techniques. The association between these markers and clinicopathologic parameters was assessed. All tumor cells studied showed enhanced p63 expression. Regarding E-cadherin expression, 17 of 22 cases (77.3%) showed decreased immunoreactivity, and in 13 of 22 cases (59.1%), its expression was cytoplasmic. Neither p63 nor E-cadherin expression patterns were associated with tumor size, bone invasion, or lymph node metastasis...
July 2015: Veterinary Pathology
https://www.readbyqxmd.com/read/25245141/hmga1-and-hmga2-expression-and-comparative-analyses-of-hmga2-lin28-and-let-7-mirnas-in-oral-squamous-cell-carcinoma
#19
COMPARATIVE STUDY
Katharina Anna Sterenczak, Andre Eckardt, Andreas Kampmann, Saskia Willenbrock, Nina Eberle, Florian Länger, Sven Kleinschmidt, Marion Hewicker-Trautwein, Hans Kreipe, Ingo Nolte, Hugo Murua Escobar, Nils Claudius Gellrich
BACKGROUND: Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC and its expression was suggested to act as a useful predictive and prognostic tool in clinical management of oral carcinomas. Herein the expression of HMGA2 and its sister gene HMGA1 were analysed within human and canine OSCC samples. Additionally, the HMGA negatively regulating miRNAs of the let-7 family as well as the let-7 regulating gene Lin28 were also comparatively analysed...
2014: BMC Cancer
https://www.readbyqxmd.com/read/24903027/determination-of-oral-bioavailability-of-fusaric-acid-in-male-sprague-dawley-rats
#20
Brendan C Stack, John Ye, Rebecca Willis, Martha Hubbard, Howard P Hendrickson
Head and neck squamous cell cancer accounts for 3 % of new cancer cases and 2 % of cancer mortality annually in the United States. Current treatment options for most head and neck cancers continue to be surgical excision with or without radiation, radiation alone, or chemotherapy with radiation depending on location, stage of disease, and patient preference. Fusaric acid (FA) is a novel compound from a novel class of nicotinic acid derivatives that have activity against head and neck squamous cell carcinoma (HNSCC)...
June 2014: Drugs in R&D
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