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CGRP monoclonal antibodies peripheral nerve pain

Olga Kuzawińska, Krzysztof Lis, Grzegorz Cessak, Dagmara Mirowska-Guzel, Ewa Bałkowiec-Iskra
Migraine is a chronic, recurrent disorder, characterized by attacks of severe pain, affecting around 1% of adult population. Many studies suggest, that trigeminovascular system plays a key role in pathogenesis of migraine and other primary headaches. Calcitonin gene-related peptide (CGRP) is an endogenous substance, which is regarded a key mediator released from trigeminovascular system after stimulation of sensory nerve endings, responsible for dilatation of peripheral vessels and sensory transmission. CGRP is and extensively studied peptide as one of the most promising targets in migraine drug research...
November 2016: Neurologia i Neurochirurgia Polska
Egle M Mambretti, Katrin Kistner, Stefanie Mayer, Dominique Massotte, Brigitte L Kieffer, Carsten Hoffmann, Peter W Reeh, Alexander Brack, Esther Asan, Heike L Rittner
BACKGROUND: Opioids are the gold standard for the treatment of acute pain despite serious side effects in the central and enteric nervous system. µ-opioid receptors (MOPs) are expressed and functional at the terminals of sensory axons, when activated by exogenous or endogenous ligands. However, the presence and function of MOP along nociceptive axons remains controversial particularly in naïve animals. Here, we characterized axonal MOPs by immunofluorescence, ultrastructural, and functional analyses...
2016: Molecular Pain
Katie E Bowler, Matthew A Worsley, Lisa Broad, Emmanuel Sher, Robert Benschop, Kirk Johnson, Fiona M Boissonade, Peter P Robinson, Julian M Yates
The development of ectopic neural discharge at a site of peripheral nerve injury is thought to contribute to the initiation of sensory disturbances and pain. We have previously shown that this discharge can be initiated or increased by the neuropeptide calcitonin gene-related peptide (CGRP). We have now studied a potential therapeutic approach to reducing the discharge by evaluating the effect of a systemically administered monoclonal antibody to CGRP on injury-induced activity in the lingual nerve. In 16 anaesthetised adult ferrets the left lingual nerve was sectioned...
November 14, 2011: Neuroscience Letters
K Takagi, E Okuda-Ashitaka, T Mabuchi, T Katano, T Ohnishi, S Matsumura, M Ohnaka, S Kaneko, T Abe, T Hirata, S Fujiwara, T Minami, S Ito
The c-kit receptor tyrosine kinase is expressed in a subpopulation of small- and medium-sized neurons of the dorsal root ganglia (DRG) and in the superficial layer of the spinal cord. Stem cell factor (SCF), a ligand of the c-kit receptor, induces neurite outgrowth from DRG and supports the survival of c-kit-expressing neurons. To clarify the possible function of the SCF/c-kit receptor system in the adult animal, we investigated the expression of c-kit receptor in the spinal cord and DRG in relation to pain by using H2C7, a newly developed anti-c-kit monoclonal antibody...
June 2, 2008: Neuroscience
Molly A Sevcik, Joseph R Ghilardi, Christopher M Peters, Theodore H Lindsay, Kyle G Halvorson, Beth M Jonas, Kazufumi Kubota, Michael A Kuskowski, Leila Boustany, David L Shelton, Patrick W Mantyh
Bone cancer pain can be difficult to control, as it appears to be driven simultaneously by inflammatory, neuropathic and tumorigenic mechanisms. As nerve growth factor (NGF) has been shown to modulate inflammatory and neuropathic pain states, we focused on a novel NGF sequestering antibody and demonstrated that two administrations of this therapy in a mouse model of bone cancer pain produces a profound reduction in both ongoing and movement-evoked bone cancer pain-related behaviors that was greater than that achieved with acute administration of 10 or 30 mg/kg of morphine...
May 2005: Pain
L S Sorkin, A L Yu, H Junger, C M Doom
Anti-GD(2) antibodies have been shown to be effective for immunotherapy of neuroblastoma and other GD(2) enriched malignancies. Infusion of anti-GD(2) antibodies frequently causes spontaneous pain and allodynia for the duration of the immunotherapy and occasionally longer lasting neuropathic pain. Bolus intravenous injection of anti-GD(2) in rats initiates mechanical allodynia as measured by withdrawal threshold of the hindpaws. In this study, thermal thresholds were measured prior to and for up to 6 h following systemic anti-GD(2) administration in adult rats...
March 15, 2002: Brain Research
Felipe, Gonzalez, Gallar, Belmonte
The number and immunocytochemical characteristics of trigeminal ganglion neurons providing sensory innervation to the cornea were studied in the mouse. Corneal neurons were retrogradely labelled with fluorogold placed on the cornea after removal of the epithelium with n-heptanol. Corneal neurons were counted, sized and characterized immunocytochemically with antisera against substance P (SP), calcitonin gene-related peptide (CGRP), calbindin, calretinin, and with a monoclonal antibody (RT97) against neurofilament proteins...
March 1999: European Journal of Pain: EJP
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