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https://www.readbyqxmd.com/read/27895316/investigating-cytokinesis-failure-as-a-strategy-in-cancer-therapy
#1
Callum McKenzie, Pier Paolo D'Avino
Effective therapeutics exploit common characteristics shared amongst cancers. As many cancers present chromosomal instability (CIN), one possible approach to treat these cancers could be to increase their CIN above a threshold that would affect their viability. Here, we investigated whether causing polyploidy by cytokinesis failure could represent a useful approach. We show that cytokinesis failure caused by depletion of Citron kinase (CIT-K) dramatically decreased cell proliferation in breast, cervical and colorectal cancer cells...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891038/accessory-atlantoaxial-ligament-avulsion-fracture-of-the-axis-are-there-any-clinical-implications
#2
Hamid Reza Niknejad, Frank van Calenbergh, Philippe Demaerel, Johannes van Loon
Injuries to the craniocervical support structures are frequently observed in neurotrauma cases. Stability of this region is of vital importance. Literature has mainly focused on three major ligaments of the craniocervical junction: The tectorial membrane, the transverse ligament, and the alar ligaments. However, the accessory atlantoaxial ligament (ALL) also seems to be involved in craniocervical stability as shown in cadaveric specimens. Still, the biomechanical importance of this structure needs to be determined, especially in trauma settings...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27884161/hpv16-integration-probably-contributes-to-cervical-oncogenesis-through-interrupting-tumor-suppressor-genes-and-inducing-chromosome-instability
#3
Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen, Fang Li
BACKGROUND: The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such integration events are poorly understood. This study aims to explore those questions by studying high risk HPV16 integration in women with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (SCC). METHODS: Specifically, HPV integration status of 13 HPV16-infected patients were investigated by ligation-mediated PCR (DIPS-PCR) followed by DNA sequencing...
November 25, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27879511/c2-c3-anterior-cervical-fusion-technical-report
#4
Michael A Finn, Joel D MacDonald
STUDY DESIGN: Retrospective review of patients at a university hospital. OBJECTIVE: To describe the anterior approach for cervical discectomy and fusion (ACDF) at C2-C3 level and evaluate its suitability for treatment of instability and degenerative disease in this region. SUMMARY OF BACKGROUND DATA: The anterior approach is commonly used for ACDF in the lower cervical spine but is used less often in the high cervical spine. METHODS: We retrospectively reviewed a database of consecutive cervical spine surgeries performed at our institution to identify patients who underwent ACDF at the C2-C3 level during a 10-year period...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27879510/clinical-and-radiographic-outcomes-of-c1-laminectomy-without-fusion-in-patients-with-cervical-myelopathy-that-is-associated-with-a-retro-odontoid-pseudotumor
#5
Mitsuru Takemoto, Masashi Neo, Shunsuke Fujibayashi, Takeshi Sakamoto, Masato Ota, Bungo Otsuki, Hiroki Kaneko, Takeshi Umebayashi
PURPOSE: A retro-odontoid pseudotumor that is not associated with rheumatoid arthritis or hemodialysis is clinically rare. The majority of surgeons select transoral resection as the surgical treatment, often followed by posterior fusion or posterior decompression and fusion. In contrast, some authors have reported success with simple decompression without posterior stabilization in cases where atlanto-axial instability (AAI) is either absent or minor. In this study, we have evaluated the clinical and radiographic outcomes of C1 laminectomy without fusion as the surgical treatment for patients with cervical myelopathy that is associated with a retro-odontoid pseudotumor...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27842476/recurrent-neurologic-deterioration-after-conservative-treatment-for-acute-traumatic-central-cord-syndrome-without-bony-injury-17-operative-cases-report%C3%AF
#6
Wenjie Jin, Xin Sun, Jia Wang, Xingzhen Liu, Xiushuai Shang, Hairong Tao, Tong Zhu, Kangping Shen
The mechanisms of late recurrent neurologic deterioration after conservative treatment for acute traumatic central cord syndrome (ATCCS) remained unclear. 17 operative cases sustaining late recurrent neurologic deterioration after conservative treatment for ATCCS were reviewed to investigate the mechanisms. The assessment of neurological status was based on International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). Gender, age, cause of injury, results of image, conservative treatment and operative data, neurological status on different time points were recorded...
November 14, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27834534/vestibular-balance-microvascular-and-white-matter-neuroimaging-characteristics-of-blast-injuries-and-mild-traumatic-brain-injury-four-case-reports
#7
Ramtilak Gattu, Faith W Akin, Anthony T Cacace, Courtney D Hall, Owen D Murnane, E Mark Haacke
BACKGROUND: Case reports are presented on four Veterans, aged 29-46 years, who complained of chronic dizziness and/or postural instability following blast exposures. Two of the four individuals were diagnosed with mild traumatic brain injury and three of the four were exposed to multiple blasts. Comprehensive vestibular, balance, gait, audiometry and neuroimaging procedures were used to characterize their injuries. CASE REPORT: Vestibular assessment included videonystagmography, rotary chair and cervical and ocular vestibular evoked myogenic potentials...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27830891/morphometric-multislice-computed-tomography-examination-of-the-craniovertebral-junction-in-neck-flexion-and-extension
#8
Slobodan Marinkovic, Ivan Milić, Igor Djorić, Luciano Brigante, Aleksandar Miljatović, Laslo Puškaš, Slobodan Kapor, Jelena Boljanović
BACKGROUND: Detailed study of the craniovertebral junction (CVJ) is necessary to completely understand the mechanism of its flexion and extension. MATERIALS AND METHODS: One cadaver head was sectioned in the sagittal plane. Also, in 22 volunteers, examined using the multislice computerized tomography (MSCT), 14 parameters and 2 angles were measured in the neutral position, flexion and extension. RESULTS: The obtained measurements showed the anterior part of the occiput to move inferiorly in flexion, and the anterior atlas arch and the tip of the dens to get closer to the basion...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27809555/quantitative-analysis-of-subtalar-joint-motion-with-4d-ct-proof-of-concept-with-cadaveric-and-healthy-subject-evaluation
#9
Pedro Augusto Gondim Teixeira, Anne-Sophie Formery, Adrien Jacquot, Guillaume Lux, Isabelle Loiret, Manuela Perez, Alain Blum
OBJECTIVE: The purpose of this study was to show the application of quantitative 4D CT for subtalar joint evaluation in healthy volunteers and cadavers. MATERIALS AND METHODS: Fifteen healthy volunteers with no history of subtalar joint trauma and three cadavers were prospectively evaluated with dynamic CT. The subtalar joint was evaluated during a pronosupination cycle. All acquisitions (cadavers and healthy volunteers) were performed using intermittent sequential mode with a 320-MDCT scanner...
November 3, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27806689/functional-variants-of-human-papillomavirus-type-16-demonstrate-host-genome-integration-and-transcriptional-alterations-corresponding-to-their-unique-cancer-epidemiology
#10
Robert Jackson, Bruce A Rosa, Sonia Lameiras, Sean Cuninghame, Josee Bernard, Wely B Floriano, Paul F Lambert, Alain Nicolas, Ingeborg Zehbe
BACKGROUND: Human papillomaviruses (HPVs) are a worldwide burden as they are a widespread group of tumour viruses in humans. Having a tropism for mucosal tissues, high-risk HPVs are detected in nearly all cervical cancers. HPV16 is the most common high-risk type but not all women infected with high-risk HPV develop a malignant tumour. Likely relevant, HPV genomes are polymorphic and some HPV16 single nucleotide polymorphisms (SNPs) are under evolutionary constraint instigating variable oncogenicity and immunogenicity in the infected host...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27800002/single-stage-operation-for-giant-schwannoma-at-the-craniocervical-junction-with-minimal-laminectomy-a-case-report-and-literature-review
#11
Sun Yoon, Hunho Park, Kyu-Sung Lee, Seoung Woo Park, Chang-Ki Hong
Here we report a single-stage operation we performed on a patient with a large schwannoma that extended from the lower clivus to the cervico-thoracic junction caudally. A number of authors have previously performed multilevel laminectomy to remove giant schwannomas that extend for considerable length. This technique has caused cervical instability such as kyphosis or gooseneck deformity on several occasions. We removed the tumor with a left lateral suboccipital craniectomy with laminectomy only at C1 and without any subsequent surgery-related neurologic deficits...
September 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/27792120/factors-that-predict-risk-of-cervical-instability-in-rheumatoid-arthritis-patients
#12
Myung-Hoon Han, Je Il Ryu, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Koang Hum Bak, Hyoung Joon Chun, Hyeong-Joong Yi, Jae Bum Jun, Jae Woo Chung
STUDY DESIGN: Retrospective data analysis. OBJECTIVES: To identify factors affecting the atlantodental interval (ADI), the Ranawat value, and subaxial translation after rheumatoid arthritis (RA) diagnosis. In addition, factors predictive for Cervical spine instability (CSI) development after RA diagnosis were examined. SUMMARY OF BACKGROUND DATA: Development of CSI affects the prognosis and mortality of RA patients. Previous studies described that obesity is associated with reduced radiographic joint damage in RA patients...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27792108/efficacy-of-intraoperative-neurophysiologic-monitoring-for-pediatric-cervical-spine-surgery
#13
Daniel G Tobert, Michael P Glotzbecker, M Timothy Hresko, Lawrence I Karlin, Mark R Proctor, John B Emans, Patricia E Miller, Daniel J Hedequist
STUDY DESIGN: Clinical case series OBJECTIVE.: To investigate the efficacy of intraoperative neuromonitoring in pediatric cervical spine surgery SUMMARY OF BACKGROUND DATA.: Intraoperative neuromonitoring (IONM) consisting of somatosensory evoked potentials (SSEP) and transcranial motor evoked potentials (tcMEP) has been shown to effectively prevent permaneny neurologic injury in deformity surgery. The role of IONM during pediatric cervical spine surgery is not well documented. Advances in cervical spine instrumentation have expanded the surgical options in pediatric populations...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27787486/minimally-invasive-cervical-spine-surgery
#14
Branko Skovrlj, Sheeraz A Qureshi
AIM: Degenerative disorders of the cervical spine requiring surgical intervention have become increasingly more common over the past decade. Traditionally, open surgical approaches have been the mainstay of surgical treatment. More commonly, minimally invasive techniques are being developed with the intent to decrease surgical morbidity and iatrogenic spinal instability. This study will review four minimally invasive cervical techniques that have been increasingly utilized in the treatment of degenerative cervical spine disease...
October 27, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27771479/surgical-management-for-destructive-atlantoaxial-spondyloarthropathy-in-long-term-hemodialysis-patients
#15
Je Hoon Jeong, Hee Kyung Kim, Soo Bin Im
BACKGROUND: Atlantoaxial spondyloarthropathy is most often resulted from rheumatoid arthritis, cancer metastasis and basilar invagination. Dialysis-related spondyloarthropathy is a rare cause of spinal deformity and cervical myelopathy at the atlantoaxial joint. We report two long-term hemodialysis patients who presented with atlantoaxial spondyloarthropathy. CASE DESCRIPTION: Two patients with end-stage renal failure (ESRD) presented with history of progressively worsening neck pain and motion limitation, and gait disturbance...
October 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27764057/can-an-anchored-cage-be-substituted-for-an-anterior-cervical-plate-and-screw-for-single-level-anterior-cervical-fusion-surgery-prediction-of-poor-candidates-through-a-review-of-early-clinical-and-radiologic-outcomes
#16
Dong Kwang Seo, Moon Kyu Kim, Soo Jung Choi, Jun Young Sohn, Young Ki Kim, Eui Kyun Jeong, Jung-Ki Ha, Chung Hwan Kim, Jin Hoon Park
STUDY DESIGN: This is a case series of device failure patients. OBJECTIVE: To identify poor candidates for anterior cervical discectomy and fusion (ACDF) using an anchored cage. SUMMARY OF BACKGROUND DATA: An anchored cage has been used as an alternative implant for ACDF surgery because of ease of use, relatively acceptable fusion rate, and lower risk of plate-related complications, including dysphagia. MATERIALS AND METHODS: We retrospectively reviewed the outcomes of 36 patients who underwent ACDF using an anchored cage between January 2012 and December 2013...
October 19, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27759677/effect-of-surgery-on-gait-and-sensory-motor-performance-in-patients-with-cervical-spondylotic-myelopathy
#17
Kingsley O Abode-Iyamah, Stephanus V Viljoen, Colleen L McHenry, Michael A Petrie, Kirsten E Stoner, Nader S Dahdaleh, Nicole M Grosland, Matthew A Howard, Richard K Shields
BACKGROUND: Cervical spondylotic myelopathy (CSM) is a common disease of aging that leads to gait instability resulting from loss of leg sensory and motor functions. The results of surgical intervention have been studied using a variety of methods, but no test has been reported that objectively measures integrative leg motor sensory functions in CSM patients. OBJECTIVE: To determine the feasibility of using a novel single leg squat (SLS) test to measure integrative motor sensory functions in patients with CSM before and after surgery...
November 2016: Neurosurgery
https://www.readbyqxmd.com/read/27756026/t-tube-placement-as-a-method-for-treating-penetrating-oesophageal-injuries
#18
Roger Christopher Gill, K M Inam Pal, Fatima Mannan, Amber Bawa, Saulat H Fatimi
INTRODUCTION: Penetrating oesophageal injuries are extremely rare. Their timely recognition can be difficult and optimal treatment remains controversial. Early recognition of injury is possible with the help of a high index of suspicion and early radiological and endoscopic examinations. Prompt surgical intervention with primary repair of injury, should be the goal. PRESENTATION OF CASES: We describe two cases of penetrating oesophageal trauma where T-Tube placement through the oesophageal defect, was successfully employed...
January 4, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27720376/anterior-cervical-interbody-fusion-using-polyetheretherketone-cage-filled-with-synthetic-bone-graft-in-acute-cervical-spine-injury
#19
L Hattou, X Morandi, J Lefebvre, P-J Le Reste, L Riffaud, P-L Hénaux
PURPOSE: The aim of this study was to assess the interbody fusion rate for patients treated by anterior cervical interbody fusion (ACIF) using polyetheretherketone (PEEK) cages filled with synthetic bone graft in acute cervical spine injury. MATERIALS AND METHODS: Twenty-nine patients (mean age: 49 years) with monosegmental instability due to cervical spine injury were followed. We assessed the rate of and time to interbody fusion at 1-year follow-up. In case of secondary displacement, we analysed its causes and surgical management...
October 5, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27716589/changes-of-proteoglycan-and-collagen-ii-of-the-adjacent-intervertebral-disc-in-the-cervical-instability-models
#20
Bin Wu, Chunyang Meng, Haibin Wang, Cunling Jia, Yifeng Zhao
OBJECTIVE: Post-operation of cervical decompression fusion and internal fixation (CDF) accelerated adjacent segment disc degeneration (ASD). It is not clear that whether instability of one single segmental accelerates the degeneration of adjacent segment disc. This study aims to explore the effect of cervical instability on the change of morphology and biochemistry in adjective segment (above) in the L5/6 cervical instability rabbit models. METHODS: Thirty-two mature New Zealand white rabbits (3000±250g) were randomly divided into two groups, control group (n=8) and model group (n=24)...
October 4, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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