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https://www.readbyqxmd.com/read/29451436/novel-posterior-artificial-atlanto-odontoid-joint-for-atlantoaxial-instability-a-biomechanical-study
#1
Kai Shen, Zhongliang Deng, Junsong Yang, Chao Liu, Ranxi Zhang
OBJECTIVE Atlantoaxial instability is usually corrected by anterior and/or posterior C1-2 fusion. However, fusion can lead to considerable loss of movement at the C1-2 level, which can adversely impact a patient's quality of life. In this study, the authors investigated the stability and function of a novel posterior artificial atlanto-odontoid joint (NPAAJ) by using cadaveric cervical spines. METHODS The Oc-C7 regions from 10 cadaveric spines were used for anteroposterior (AP) translation and range of motion (ROM) tests while intact and after destabilization, NPAAJ implantation, and double-rod fixation...
February 16, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29450715/utility-of-mri-for-cervical-spine-clearance-in-blunt-trauma-patients-after-a-negative-ct
#2
Ajay Malhotra, David Durand, Xiao Wu, Bertie Geng, Khalid Abbed, Diego B Nunez, Pina Sanelli
PURPOSE: To determine the utility of cervical spine MRI in blunt trauma evaluation for instability after a negative non-contrast cervical spine CT. METHODS: A review of medical records identified all adult patients with blunt trauma who underwent CT cervical spine followed by MRI within 48 h over a 33-month period. Utility of subsequent MRI was assessed in terms of findings and impact on outcome. RESULTS: A total of 1,271 patients with blunt cervical spine trauma underwent both cervical spine CT and MRI within 48 h; 1,080 patients were included in the study analysis...
February 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29430326/-adult-grisel-syndrome-and-cervical-skull-instability-transnasal-endoscopic-odontoidectomy-and-occipito-cervical-fusion-case-report-and-literature-review
#3
Roberto Herrera, Héctor Rojas, Ariel Estramian, Julieta Gómez, José Luis Ledesma, José Pablo, Julián Pastore
Background: Craniocervical junction pathology is infrequent in daily neurosurgical practice. In general, most of these lesions are of traumatic or rheumatic origin. Atlantoaxial instability of inflammatory origin (Grisel syndrome) is a rare entity of which only 16 adult cases have been reported in the literature. This pathology is characterized by the development of an osteolytic lesion at the level of the atlantoaxial joint after an infectious event, usually of the upper airways. Case Description: We present the case of a 76-year-old patient who attended our office for clinical symptoms of spinal instability secondary to an osteolytic lesion, with involvement of C1 and C2...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29429252/-long-term-follow-up-of-c-1-c-2-pedicle-screw-fixation-for-pediatric-atlantoaxial-dislocation
#4
B Lin, Z D Chen, T Y Cai, S S Wu, Z M Guo
Objective: To investigate the clinical curative effect of C(1)-C(2) pedicle screw fixation for pediatric atlantoaxial dislocation after a long-term follow-up. Methods: From March 2005 to April 2011, a total of 12 male and 9 female patients were included, with age from 3 to 9 years old (mean, 6.1 years old). Among them, 14 cases (67%) had typeⅠinstability atlantoaxial dislocation, 7 cases (33%) had type Ⅱ reducible atlantoaxial dislocation. All 21 pediatric patients with atlantoaxial dislocation underwent posterior pedicle screw fixations...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29404657/catecholamine-crisis-during-induction-of-general-anesthesia-a%C3%A2-case-report
#5
M Sonntagbauer, A Koch, U Strouhal, K Zacharowski, C F Weber
Catecholamine crises associated with pheochromocytoma may cause life-threatening cardiovascular conditions. We report the case of a 75-year-old male who developed a hypertensive crisis during induction of general anesthesia for elective resection of a cervical neuroma due to an undiagnosed pheochromocytoma. Hemodynamic instability occurred immediately after the injection of fentanyl, propofol and rocuronium, prior to laryngoscopy and in the absence of any manipulation of the abdomen. In this case report, we present the management of this incident and discuss the underlying pathophysiology triggering a catecholamine crisis...
February 5, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29403308/the-relationship-between-the-pd-1-pd-l1-pathway-and-dna-mismatch-repair-in-cervical-cancer-and-its-clinical-significance
#6
Yang-Chun Feng, Wen-Li Ji, Na Yue, Yan-Chun Huang, Xiu-Min Ma
Background: According to recent clinical observations, deficient DNA mismatch repair (dMMR) is capable of improving antitumor effects of the PD-1/PD-L1 pathway, suggesting that dMMR may act as a prognostic indicator of PD-1/PD-L1 antibody drugs. In this study, we examined the dMMR and PD-1/PD-L1 expression, as well as explored the correlation of dMMR status with PD-1/PD-L1 expression in cervical cancer patients, in order to optimize cervical cancer patient selection for PD-1/PD-L1 antibody drug treatment, which is helpful to avoid adverse effects and keep costs manageable...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29403245/machined-cervical-interfacet-allograft-spacers-for-the-management-of-atlantoaxial-instability
#7
Mazda K Turel, Mena G Kerolus, Vincent C Traynelis
Background: The use of cervical interfacet spacers (CISs) to augment stability and provide solid arthrodesis at the atlantoaxial joint has not been studied in detail. The aim of this work is to report the outcomes with the use of machined allograft CISs at C1-2. Methods: A retrospective review of 19 patients who underwent an atlantoaxial fusion with the use of CISs was performed. All patients had instability documented with flexion and extension lateral radiographs...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29403244/occipitocervical-fusion-an-epidemiological-drift-experienced-in-an-irish-tertiary-spinal-referral-center-twenty-year-follow-up-study
#8
Nadim Tarazi, Sudarshan Munigangaiah, Aiden T Devitt, John P Mccabe
Background: Occipitocervical disease is common in the elderly population, and is on the rise due to an increasingly aging population. Methods: We retrospectively reviewed all patients who underwent occipitocervical fusion in our institution over a 20 year period (1996-2016) at a tertiary spinal referral centre. Patients were divided in 2 groups. Group A included all patient who underwent OCF in the first decade between 1996 and 2005. Group B was all patients who underwent OCF in the second decade between 2006 and 2016...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29392340/decompression-for-cervical-disc-herniation-using-the-full-endoscopic-anterior-technique
#9
REVIEW
S Oezdemir, M Komp, P Hahn, S Ruetten
OBJECTIVE: Resection of a cervical disc herniation using a full-endoscopic technique with an anterior approach. INDICATION: Fresh disc herniation with monoradicular symptoms in the upper extremity. CONTRAINDICATIONS: Pure neck pain, cervical myelopathy, older and calcified disc herniations, higher grade of instability and deformity. SURGICAL TECHNIQUE: Introduction of a guidewire and dilatator to a cervical disc using an anterior approach...
February 1, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29369342/case-report-of-endometrial-cancer-with-a-microcytic-elongated-and-fragmented-pattern-of-invasion-and-dna-mismatch-repair-deficiency
#10
Janhvi Sookram, Julieta E Barroeta, James K Aikins
Uterine risk factors, such as tumor size and grade, depth of myometrial invasion, cervical stromal involvement, and lympho-vascular space invasion are predictive of outcomes in early-stage endometrial cancers and guide therapeutic decisions. A microcytic, elongated, and fragmented (MELF) pattern of invasion has also been implicated in poor patient prognoses, given the aggressive potential of tumors with this morphology for lympho-vascular space invasion and nodal metastases [1, 2]. Similarly, Lynch-related DNA mismatch repair protein expression has been utilized increasingly and an association between microsatellite instability and worsening survival outcomes in endometrial cancers has been demonstrated [3]...
January 25, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29350639/dynamic-mri-in-the-evaluation-of-the-spine-state-of-the-art
#11
Giulia Michelini, Antonella Corridore, Silvia Torlone, Federico Bruno, Claudia Marsecano, Raffaella Capasso, Ferdinando Caranci, Antonio Barile, Carlo Masciocchi, Alessandra Splendiani
INTRODUCTION: Degenerative disease of the spine is a generic term encompassing a wide range of different disease processes, which leads to spinal instability; traumatic/neoplastic events can accelerate this aging process. Therefore, the dynamic nature of the spine and its mobility across multiple segments is difficult to depict with any single imaging modality. METHODS: A review of PubMed databases for articles published about kMRI in patients with cervical and lumbar spinal desease was performed...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29338912/-surgical-outcomes-of-traumatic-cervical-fractures-in-patients-with-ankylosing-spondylitis
#12
Alberto Isla Guerrero, Beatriz Mansilla Fernández, Borja Hernández Garcia, Álvaro Gómez de la Riva, María Luisa Gandía González, Elena Isla Paredes
OBJECTIVE: Ankylosing spondylitis is an inflammatory rheumatic disease mainly affecting the axial skeleton. The rigid spine may secondarily develop osteoporosis, further increasing the risk of spinal fracture. In this study, we reviewed fractures in patients with ankylosing spondylitis that had been clinically diagnosed to better define the mechanism of injury, associated neurological deficit, predisposing factors, and management strategies. METHODS: Between January 2004 and December 2014, 6 patients with ankylosing spondylitis and neurological complications after injuries were treated...
January 12, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29338484/the-association-between-micronucleus-nucleoplasmic-bridges-and-nuclear-buds-frequency-and-the-degree-of-uterine-cervical-lesions
#13
Goneta Gashi, Vesna Mahovlić, Suzana Manxhuka-Kerliu, Arjeta Podrimaj-Bytyqi, Luljeta Gashi, Isa R Elezaj
BACKGROUND AND AIM: The loss of genomic stability play an important role in carcinogenesis. Therefore, it is imperative to use certain biomarkers of DNA damage due to genomic instability in order to predict cancer risk. The aim of this study was the evaluation of genomic instability in patients with cervical lesions. MATERIALS AND METHODS: We investigated the genetic damages in 80 subjects: (40) patients with high grade squamous intraepithelial lesions (HSIL), (20) patients with invasive squamous cervical cancer (SCC) and (20) healthy women with a biomarker in two different tissues; the micronucleus (MN) test in peripheral blood lymphocytes (PBL), and in buccal exfoliated cells (BEC)...
January 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29337161/cellular-redox-cancer-and-human-papillomavirus
#14
REVIEW
Alfredo Cruz-Gregorio, Joaquín Manzo-Merino, Marcela Lizano
High-risk Human Papillomavirus (HR-HPV) is the causative agent of different human cancers. A persistent HR-HPV infection alters several cellular processes involved in cell proliferation, apoptosis, immune evasion, genomic instability and transformation. Cumulative evidence from past studies indicates that HR-HPV proteins are associated with oxidative stress (OS) and has been proposed as a risk factor for cancer development. Reactive oxygen and nitrogen species (RONS) regulate a plethora of processes inducing cellular proliferation, differentiation and death...
February 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29330570/open-door-laminoplasty-what-can-the-unilateral-approach-offer
#15
REVIEW
R Kothe, G Schmeiser, L Papavero
OBJECTIVE: Multilevel posterior decompression of subaxial cervical spinal canal stenosis through a less-invasive unilateral approach. INDICATIONS: Degenerative cervical myelopathy due to multilevel subaxial spinal canal stenosis. CONTRAINDICATIONS: Cervical kyphosis or instability, bilateral radiculopathy due to foraminal stenosis, involvement of C2 or C7. SURGICAL TECHNIQUE: Unilateral subaxial approach with detachment of muscles only on one side...
January 12, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29329740/criteria-to-screen-for-traumatic-cervical-spine-instability-a-consensus-of-chiropractic-radiologists
#16
Sarah Dion, Maja Stupar, Pierre Côté, Julie-Marthe Grenier, John A Taylor
OBJECTIVE: The purpose of this study was to establish consensus on a radiographic definition for cervical instability for routine use in chiropractic patients who sustain trauma to the cervical spine. METHOD: We conducted a modified Delphi study with a panel of chiropractic radiologists. Panelists were asked to rate potential screening criteria for traumatic cervical spine instability when assessing cervical spine radiographs. Items rated as important for inclusion by at least 60% of participants in round 1 were submitted for a second round of voting in round 2...
January 9, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29327864/limits-of-endoscopic-endonasal-approach-for-cranio-vertebral-junction-tumors
#17
Matteo Zoli, Nicolò Rossi, Filippo Friso, Carmelo Sturiale, Giorgio Frank, Ernesto Pasquini, Diego Mazzatenta
INTRODUCTION: The endoscopic endonasal approach has been recently proposed for cranio-vertebral junction lesions. The more common indication for this sagittal extension of the endonasal route is represented by odontoidectomy for irreducible ventral brainstem compression due to congenital or degenerative conditions. However, in an increasing number of studies its adoption for tumors involving the cranio-cervical junction has been reported. The aim of this study is to consider retrospectively our surgical series, focusing on the advantages and limits of this approach...
January 10, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29325950/a-novel-technique-for-cervical-laminoplasty-fusion-clpf-simultaneously-enhancing-stabilization-and-decompression-in-various-cervical-myelopathies-a-technical-note-and-outcomes
#18
Il Sup Kim, Jae Taek Hong, Jung Jae Lee, Jong Bum Lee, Chul Bum Cho, Seung Ho Yang, Jae Hoon Sung
PURPOSE: Cervical laminectomy has two major disadvantages: post-laminectomy adhesion of dural membrane and the lack of a fusion bed. The objective of this study was to determine whether simultaneous laminoplasty with fusion (CLPF) might overcome these unwanted outcomes. METHODS: Cases of CLPF for treating various cervical myelopathy with instability who were followed up for at least 12 months were enrolled. Preoperative and postoperative Neck Disability Index (NDI), Japanese Orthopedic Association (JOA) scores before and after surgeries, recovery rates (RRs), C2-7 lordosis, and fusion success rates were evaluated...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325524/posterior-decompression-and-occipitocervical-fixation-followed-by-intraoperative-vertebroplasty-for-metastatic-involvement-of-the-axis
#19
Xinjie Wu, Mingsheng Tan, Yingna Qi, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
BACKGROUND: Metastases to the upper cervical spine were rarely reported in the literature. However, metastases to this area may cause spinal instability and cord compression, which in turn can result in respiratory failure and neurological dysfunction. The present study investigated the efficacy and safety of posterior decompression and occipitocervical fixation followed by intraoperative vertebroplasty for this disease. METHODS: This was a retrospective study that included 10 patients with metastatic involvement of the axis from March 2002 to May 2014...
January 11, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29325196/ventral-slot-surgery-to-manage-cervical-intervertebral-disc-disease-in-three-cats
#20
Abbe Harper Crawford, Rodolfo Cappello, Akash Alexander, Steven De Decker
OBJECTIVE:  This case series describes the clinical presentation, management and outcome of three cats diagnosed with cervical intervertebral disc disease that underwent decompressive ventral slot surgery. METHODS:  This is a retrospective case series evaluating client-owned cats undergoing a ventral slot surgical procedure to manage cervical intervertebral disc disease (n = 3). RESULTS:  A routine ventral slot surgery was performed in each case without complication, resulting in postoperative neurological improvement in all three cases...
January 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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