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https://www.readbyqxmd.com/read/28932365/causal-role-of-infectious-agents-in-cancer-an-overview
#1
REVIEW
Jila Masrour-Roudsari, Soheil Ebrahimpour
Cancer is a complex group of diseases with multiple eventual causes. The underlying causes are not fully known. Thus, learning more about the known causes of cancer is an important issue. Moreover, among these factors, infection and its association to cancers is controversial. Although, it seems that the genome instability of the cells can initiate cancer development. The purpose of this review was to present the role of infection in the development of cancer. Infectious agents, such as hepatitis B (HBV) and C viruses (HCV), Epstein-Barr virus (EBV), human papillomavirus (HPV), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori (H...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28919610/open-door-laminoplasty-for-multilevel-cervical-spondylotic-myelopathy-and-ossification-of-the-posterior-longitudinal-ligament-opll-using-titanium-reconstruction-miniplate-and-screws
#2
M K Ahsan, M A Awwal, S I Khan, N Zaman, M H Haque, Z Zahangiri
To review outcome of 25 patients who underwent open-door cervical laminoplasty for multilevel cervical spondylotic myelopathy (MCSM) and ossification of the posterior longitudinal ligament (OPLL) using titanium reconstruction miniplate and screws. Records of 18 men and 7 women aged 35 to 78 (mean, 62.6) years were reviewed retrospectively from October 2009 and October 2014 at Bangabandhu Sheikh Mujib Medical University (BSMMU) and in our private settings, Dhaka, Bangladesh. Four patients had 5 levels (C3-C7), 21 patients had 4 levels (C3-C6) decompression and 3 patients (12%) performed foraminotomies...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28902102/post-traumatic-spinal-hygroma-causing-cord-compression-in-type-iii-odontoid-fracture-with-vertical-atlantoaxial-instability
#3
Salvatore Russo, Antonio Belli, Andy Eynon, Ali Nader-Sepahi
STUDY DESIGN: Case report. OBJECTIVE: To report the first case in the literature of a traumatic cervical spine subdural cerebrospinal fluid (CSF) collection (hygroma) under tension causing cord compression. We suggest etiopathogenesis and modality of treatment. SUMMARY OF BACKGROUND DATA: Hygromas are subdural cranial CSF collection. A literature review showed no previous published case of post-traumatic spinal hygroma. This was a potential life-threatening sequelae of a high cervical injury that warranted early diagnosis and emergency treatment...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28899836/spinal-hydatid-cyst-disease
#4
Yurdal Gezercan, Ali Ihsan Ökten, Gökhan Çavuş, Vedat Açik, Emre Bilgin
OBJECTIVE: A hydatic cyst (HC) is a zoonotic infection affecting the liver and lungs, with rare spinal involvement. We discuss the long-term results of 8 spinal HC patients who were monitored at our clinic for 7-15 years. METHODS: The demographic data and clinicopathological parameters of 8 spinal HC patients diagnosed between 2000-2016 were evaluated for their contribution to recurrence and long-term follow-up results were examined. RESULTS: Four male and 4 female patients with a median age of 30...
September 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28885370/usefulness-of-titanium-mesh-cage-for-posterior-c1-c2-fixation-in-patients-with-atlantoaxial-instability
#5
Hwan-Seo Yang, Ki-Wan Kim, Young-Min Oh, Jong-Pil Eun
The aim of this study was to investigate the usefulness of titanium mesh cage as an interlaminar spacer combined with nitinol shape memory loop fixation in patients with atlantoaxial instability.From April 2009 to March 2017, among the patients with atlantoaxial instability, a total of 30 patients were treated by nitinol shape memory loop fixation combined with titanium mesh cage as a spacer. We retrospectively reviewed 30 enrolled patients. Successful fusion was determined as improvement of symptoms and radiologic findings of bone fusion...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885292/incidence-and-risk-factors-of-anterior-arch-fracture-of-the-atlas-following-c1-laminectomy-without-fusion
#6
Takayoshi Shimizu, Bungo Otsuki, Shunsuke Fujibayashi, Shinji Kumamoto, Yasukazu Hijikata, Yu Shimizu, Mitsuru Takemoto, Masato Ota, Hideo Ito, Shuichi Matsuda
STUDY DESIGN: A retrospective multi-center study OBJECTIVE.: To identify the incidence of anterior arch fracture (AAF) of the atlas following C1 (first cervical vertebra) laminectomy without fusion, and its risk factors. SUMMARY OF BACKGROUND DATA: C1 laminectomy without fusion is a widely accepted surgical procedure performed to decompress the spinal cord that is compromised at the C1/C2 level, but without instability. Several case series have reported spontaneous AAF following this procedure...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28882525/multi-level-posterior-foraminotomy-with-laminoplasty-versus-laminoplasty-alone-for-cervical-spondylotic-myelopathy-with-radiculopathy-a-comparative-study
#7
Dong-Ho Lee, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Chunghwan Kim, Jung-Ki Ha
BACKGROUND CONTEXT: Conventional laminoplasty is useful for expanding a stenotic spinal canal. However, it has limited use for the decompression of accompanying neural foraminal stenosis. As such, an additional posterior foraminotomy could be simultaneously applied, although this procedure carries a risk of segmental kyphosis and instability. PURPOSE: The aim was to elucidate the long-term surgical outcomes of additional posterior foraminotomy with a laminoplasty for cervical spondylotic myelopathy (CSM) with radiculopathy...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28881717/5-aza-2-deoxycytidine-dac-treatment-downregulates-the-hpv-e6-and-e7-oncogene-expression-and-blocks-neoplastic-growth-of-hpv-associated-cancer-cells
#8
Maximilian Stich, Lennard Ganss, Jens Puschhof, Elena-Sophie Prigge, Miriam Reuschenbach, Ana Guiterrez, Svetlana Vinokurova, Magnus von Knebel Doeberitz
High-risk human papillomaviruses (hr HPVs) may cause various human cancers and associated premalignant lesions. Transformation of the host cells is triggered by overexpression of the viral oncogenes E6 and E7 that deregulate the cell cycle and induce chromosomal instability. This process is accompanied by hypermethylation of distinct CpG sites resulting in silencing of tumor suppressor genes, inhibition of the viral E2 mediated control of E6 and E7 transcription as well as deregulated expression of host cell microRNAs...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881121/the-predictable-factors-of-the-postoperative-kyphotic-change-of-sagittal-alignment-of-the-cervical-spine-after-the-laminoplasty
#9
Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Dong Ha Kim, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28875320/-low-back-pain-in-rheumatoid-arthritis
#10
REVIEW
R Kothe
Low back pain (LBP) in patients with rheumatoid arthritis (RA) has so far been of little concern in clinical investigations. The main focus of scientific publications on spinal problems in RA was the cervical spine. In a recent study, we could demonstrate that LBP in RA patients leads to a significantly higher degree of disability and depression as well as to a reduction in quality of life compared to RA patients without LBP. If there is a specific reason for the additional symptom of LBP, such as spinal stenosis or segmental instability, surgical treatment may be indicated to improve disability and quality of life...
September 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28858386/ultrasonographic-identification-of-the-dorsal-atlantoaxial-ligament-in-dogs
#11
Felipe de Vicente, Gawain Hammond
OBJECTIVE: To determine the ability to identify the dorsal atlantoaxial ligament during ultrasonographic examination of dogs. STUDY DESIGN: Canine cadaveric study. SAMPLE POPULATION: Canine cervical spines (n = 35). METHODS: Thirty-five canine cadavers with an estimated body weight of 6-35 kg were retrieved. Five cervical spines were dissected to assess the length and thickness of the dorsal atlantoaxial ligament and correlate ultrasound-guided injection of ink with anatomical dissection...
August 31, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28852840/biomechanical-study-of-novel-unilateral-c1-posterior-arch-screws-and-c2-laminar-screws-combined-with-an-ipsilateral-crossed-c1-c2-pedicle-screw-rod-fixation-for-atlantoaxial-instability
#12
Kai Shen, Zhongliang Deng, Junsong Yang, Chao Liu, Ranxi Zhang
INTRODUCTION: Current surgical methods to treat atlantoaxial instability pose potential risks to the surrounding blood vessels and nerves of operative approach. Therefore, more secure and highly effective methods are expected. This study sought to assess the biomechanical efficacy of a novel unilateral double screw-rod fixation system by comparing with traditional and emerging fixation methods in cadaveric models. MATERIALS AND METHODS: Ligamentous cervical spines (C0-C7) from ten fresh cadaveric specimens were used to complete range of motion (ROM) test in their intact condition (control group), destabilization, and stabilization after different fixations, including unilateral C1-C2 pedicle screws (PS) with a screw-rod system (Group A), bilateral C1-C2 PS with screw-rod systems (Group B), unilateral C1 posterior arch screws (PAS) and C2 laminar screws (LS) combined with an ipsilateral paralleled C1-C2 PS-rod (Group C), and unilateral C1 PAS and C2 LS combined with an ipsilateral crossed C1-C2 PS-rod (Group D)...
August 29, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28840453/immunotherapy-in-gynecologic-cancers-are-we-there-yet
#13
REVIEW
Janelle B Pakish, Amir A Jazaeri
Immune-targeted therapies have demonstrated durable responses in many tumor types with limited treatment options and poor overall prognosis. This has led to enthusiasm for expanding such therapies to other tumor types including gynecologic malignancies. The use of immunotherapy in gynecologic malignancies is in the early stages and is an active area of ongoing clinical research. Both cancer vaccines and immune checkpoint inhibitor therapy continue to be extensively studied in gynecologic malignancies. Immune checkpoint inhibitors, in particular, hold promising potential in specific subsets of endometrial cancer that express microsatellite instability...
August 24, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28839952/a-case-of-real-spinal-cord-injury-without-radiologic-abnormality-in-a-pediatric-patient-with-spinal-cord-concussion
#14
Hiroki Nagasawa, Kouhei Ishikawa, Ryosuke Takahashi, Ikuto Takeuchi, Kei Jitsuiki, Hiromichi Ohsaka, Kazuhiko Omori, Youichi Yanagawa
INTRODUCTION: Real spinal cord injury without radiologic abnormality (SCIWORA) is a rare clinical entity. CASE PRESENTATION: The patient was a 13-year-old girl whose body was overturned anteriorly after crashing her bicycle into a curb. Following the accident, in which her neck and upper back hit the ground, she could not move due to paralysis. On arrival, she had paresis of the bilateral upper extremities and experienced a painful sensation when her upper extremities were touched...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28816881/the-shikani-optical-stylet-as-an-alternative-to-awake-fiberoptic-intubation-in-patients-at-risk-of-secondary-cervical-spine-injury-a-randomized-controlled-trial
#15
Rabab S S Mahrous, Aly M M Ahmed
BACKGROUND: Conventional intubation of the trachea and consequent prone positioning of anesthetized patients with cervical spine instability may result in secondary neurological injury. Historically, flexible fiberoptics used to be the chief choice for patients presenting with cervical spine instability surgery with difficult airway. Recently, the rigid optical stylets have shown promise in assisting difficult intubations. PURPOSE: The aim of the present study was to compare the efficacy of Shikani optical stylet (SOS) with the flexible fiberscope for awake intubation in patients with cervical spine instability...
August 14, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28799855/surgical-management-of-cervical-spine-deformity-in-chondrodysplasia-punctata
#16
Nobuhito Morota, Satoshi Ihara, Hideki Ogiwara, Goichiro Tamura
OBJECTIVE Chondrodysplasia punctata (CDP), a rare skeletal dysplasia, can lead to cervical spine instability and deformity. However, an optimal neurosurgical intervention has yet to be established. Thus, a retrospective study was conducted to assess the efficacy of various surgical interventions for children with CDP. METHODS The authors retrospectively reviewed 9 cases of CDP in which cervical decompression with or without posterior fusion was performed between April 2007 and May 2016. Patient demographics, preoperative clinical conditions, radiographic findings, surgical procedures, and the postoperative course were analyzed in detail...
August 11, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28795009/evaluation-and-management-of-shoulder-pain-in-skeletally-immature-athletes
#17
REVIEW
Dilip R Patel, Stephen Breisach
Shoulder pain in young athletes generally is a result of poor sports technique and overuse. A number intrinsic causes of shoulder pain have been identified. Pain may also be referred to shoulder area from cervical spine, neck and chest pathology. Overuse stress injury of the proximal humeral physis is important to recognize early in order to prevent later complications. Shoulder impingement syndrome is a general term used to describe multiple underlying lesions and relatively uncommon in young athletes. In adolescent athletes, glenohumeral instability is an important underlying pathomechanical basis for shoulder pain...
July 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28771191/somatic-host-cell-alterations-in-hpv-carcinogenesis
#18
REVIEW
Tamara R Litwin, Megan A Clarke, Michael Dean, Nicolas Wentzensen
High-risk human papilloma virus (HPV) infections cause cancers in different organ sites, most commonly cervical and head and neck cancers. While carcinogenesis is initiated by two viral oncoproteins, E6 and E7, increasing evidence shows the importance of specific somatic events in host cells for malignant transformation. HPV-driven cancers share characteristic somatic changes, including apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-driven mutations and genomic instability leading to copy number variations and large chromosomal rearrangements...
August 3, 2017: Viruses
https://www.readbyqxmd.com/read/28768872/high-risk-alpha-papillomavirus-oncogenes-impair-the-homologous-recombination-pathway
#19
Nicholas A Wallace, Sujita Khanal, Kristin L Robinson, Sebastian O Wendel, Joshua J Messer, Denise A Galloway
Persistent high risk genus α human papillomavirus (HPV) infections cause nearly every cervical carcinoma and a subset of tumors in the oropharyngeal tract. During the decades required for HPV-associated tumorigenesis, the cellular genome becomes significantly destabilized. Our analysis of cervical tumors from 4 separate data sets found a significant upregulation of the homologous recombination (HR) pathway genes. The increased abundance of HR proteins can be replicated in primary cells by expression of the two HPV oncogenes (E6 and E7) required for HPV-associated transformation...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28761503/there-is-no-evidence-that-laminoplasty-results-in-improved-outcomes-compared-with-laminectomy-in-cervical-spinal-cord-injury-without-instability
#20
COMMENT
Shayan Abdollah Zadegan, Vafa Rahimi-Movaghar
No abstract text is available yet for this article.
July 2017: Asian Journal of Neurosurgery
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