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https://www.readbyqxmd.com/read/29770122/acute-unilateral-audiovestibulopathy-due-to-embolic-labyrinthine-infarction
#1
Zhong Liqun, Kee-Hong Park, Hyo-Jung Kim, Sun-Uk Lee, Jeong-Yoon Choi, Ji-Soo Kim
Introduction: Labyrinthine infarction is a cause of acute audiovestibulopathy, but can be diagnosed only in association with other infarctions involving the brainstem or cerebellar areas supplied by the anterior inferior cerebellar artery (AICA) since current imaging techniques cannot visualize an infarction confined to the labyrinth. This case series aimed to establish embolic labyrinthine infarction as a mechanism of isolated acute audiovestibulopathy. Methods: We analyzed clinical features, imaging findings, and mechanisms of embolism in 10 patients (8 men, age range: 38-76) who had developed acute audiovestibulopathy in association with an obvious source of embolism and concurrent acute embolic infarctions in the non-anterior inferior cerebellar artery territories...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29757361/effects-of-rhinoplasty-on-labyrinthine-function
#2
Ahmet Mahmut Tekin, Erkan Soylu, Handan Turan Dizdar, Fahrettin Yilmaz, Yildirim Ahmet Bayazit
Background: Rhinoplasty is a common surgical procedure that is requested and accepted by patients for cosmetic and functional reasons. Osteotomies are performed on nasal bone, maxillary crest, or vomer to fix the deviations of the nasal dorsum or septum. During the percussion of the osteotomes with the surgical mallet, the vibration energy diffuses to the cranium. Auditory and vestibular systems may be affected by these vibrations. Objectives: To assess the effects of rhinoplasty, in which osteotomies were performed using a hammer, on the audiovestibular system...
May 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29753845/gestational-di-2-ethylhexyl-phthalate-exposure-causes-fetal-intrauterine-growth-restriction-through-disturbing-placental-thyroid-hormone-receptor-signaling
#3
Zhen Yu, Yan Han, Ru Shen, Kun Huang, Yuan-Yuan Xu, Qu-Nan Wang, Shan-Shan Zhou, De-Xiang Xu, Fang-Biao Tao
Previous study reported that gestational Di-(2-ethylhexyl) phthalate (DEHP) exposure caused fetal intrauterine growth restriction (IUGR). We aimed to investigate the role of placental thyroid hormone receptor (THR) signaling in DEHP-induced IUGR. Dams were treated with DEHP (50 or 200 mg/kg) by gavage daily throughout pregnancy. As expected, gestational DEHP exposure dose-dependently caused fetal IUGR. The mRNA levels of placental Thrα1 and Thrβ1 were reduced and nuclear translocation of placental THRα1 and THRβ1 were suppressed in DEHP-exposed mice even though thyroid hormones in maternal and fetal sera were unaffected...
May 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29738611/influence-of-graviceptors-stimulation-initiated-by-off-vertical-axis-rotation-on-ventilation
#4
O Kuldavletova, S Marie, P Denise, H Normand
NEW FINDINGS: What is the central question of this study? It is known that respiration is affected by graviceptors, but it remains unclear to what extent labyrinthine and non-labyrinthine graviceptors are involved in this process. What is the main finding and its importance? Our results suggest that the respiration modulation is not a result of a simple reflex arc, but that it involves a higher integration of different types of receptors with variable contribution of either type of graviceptors among subjects...
May 8, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29699384/tgf-%C3%AE-induces-smad2-phosphorylation-are-induction-and-trophoblast-differentiation
#5
Renee E Albers, Kaisa Selesniemi, David R C Natale, Thomas L Brown
Background: Transforming growth factor beta (TGF-β) signaling has been shown to control a large number of critical cellular actions such as cell death, differentiation, and development and has been implicated as a major regulator of placental function. SM10 cells are a mouse placental progenitor cell line, which has been previously shown to differentiate into nutrient transporting, labyrinthine-like cells upon treatment with TGF-β. However, the signal transduction pathway activated by TGF-β to induce SM10 progenitor differentiation has yet to be fully investigated...
April 30, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29685082/peripheral-vestibular-disorders-in-children-and-adolescents-with-concussion
#6
Jacob R Brodsky, Talia N Shoshany, Sophie Lipson, Guangwei Zhou
Objective To review peripheral vestibular disorders in pediatric patients with dizziness following concussion. Study Design Case series with chart review. Setting Pediatric vestibular clinic and pediatric multidisciplinary concussion clinic at a tertiary level pediatric hospital. Subjects and Methods We retrospectively reviewed 109 patients seen for dizziness following a concussion between September 2012 and July 2015. Patients were ≤20 years of age at the time of concussion. Incidences of specific peripheral vestibular disorders were assessed along with timing of diagnosis relative to the date of injury, diagnostic test findings, and treatment interventions associated with those diagnoses...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29610337/human-bony-labyrinth-is-an-indicator-of-population-history-and-dispersal-from-africa
#7
Marcia S Ponce de León, Toetik Koesbardiati, John David Weissmann, Marco Milella, Carlos S Reyna-Blanco, Gen Suwa, Osamu Kondo, Anna-Sapfo Malaspinas, Tim D White, Christoph P E Zollikofer
The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29599061/cholesteatoma-labyrinthine-fistula-prevalence-and-impact
#8
Letícia P Schmidt Rosito, Inesângela Canali, Adriane Teixeira, Mauricio Noschang Silva, Fábio Selaimen, Sady Selaimen da Costa
INTRODUCTION: Labyrinthine fistula is one of the most common complications associated with cholesteatoma. It represents an erosive loss of the endochondral bone overlying the labyrinth. Reasons for cholesteatoma-induced labyrinthine fistula are still poorly understood. OBJECTIVE: Evaluate patients with cholesteatoma, in order to identify possible risk factors or clinical findings associated with labyrinthine fistula. Secondary objectives were to determine the prevalence of labyrinthine fistula in the study cohort, to analyze the role of computed tomography and to describe the hearing results after surgery...
March 9, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29535601/analysis-of-vestibular-labyrinthine-geometry-and-variation-in-the-human-temporal-bone
#9
Lejo Johnson Chacko, Dominik T Schmidbauer, Stephan Handschuh, Alen Reka, Karl D Fritscher, Patrik Raudaschl, Rami Saba, Michael Handler, Peter P Schier, Daniel Baumgarten, Natalie Fischer, Elisabeth J Pechriggl, Erich Brenner, Romed Hoermann, Rudolf Glueckert, Anneliese Schrott-Fischer
Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29499424/transnasal-endoscopic-and-lateral-approaches-to-the-clivus-a-quantitative-anatomic-study
#10
Francesco Doglietto, Marco Ferrari, Davide Mattavelli, Francesco Belotti, Vittorio Rampinelli, Hussein Kheshaifati, Davide Lancini, Alberto Schreiber, Tommaso Sorrentino, Marco Ravanelli, Barbara Buffoli, Lena Hirtler, Roberto Maroldi, Piero Nicolai, Luigi Fabrizio Rodella, Marco Maria Fontanella
BACKGROUND: Transnasal endoscopic approaches to the clivus have been established recently. Comparative analyses with classic lateral approaches are limited. In this study, we compared transnasal endoscopic and lateral approaches to the clivus, quantifying the exposure and working volume of each approach in the anatomy laboratory. METHODS: High-resolution computed tomography scans were performed on 5 injected specimens (10 sides). In each specimen, transnasal endoscopic approaches (i...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29498717/paroxysmal-positional-vertigo-despite-complete-vestibular-impairment-the-role-of-instrumental-assessment
#11
A P Casani, N Cerchiai, E Navari
Lindsay and Hemenway syndrome is characterised by a posterior canal benign paroxysmal positional vertigo following a partial unilateral vestibular loss affecting the same side. The syndrome is caused by damage of structures innervated by the superior division of the vestibular nerve and perfused by the anterior vestibular artery; the detached otoconia can cause vertigo in the still intact posterior semicircular canal. The most recent vestibular instrumental techniques allow reaching an accurate topodiagnosis in case of peripheral vestibular failure...
February 28, 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29405961/sirtuin1-is-required-for-proper-trophoblast-differentiation-and-placental-development-in-mice
#12
Kanaga Arul Nambi Rajan, Marwa Khater, Francesca Soncin, Donald Pizzo, Matteo Moretto-Zita, Jonathan Pham, Orysya Stus, Pooja Iyer, Veronique Tache, Louise C Laurent, Mana M Parast
INTRODUCTION: Placental insufficiency, arising from abnormal trophoblast differentiation and function, is a major cause of fetal growth restriction. Sirtuin-1 (Sirt1) is a ubiquitously-expressed NAD-dependent protein deacetylase which plays a key role in numerous cellular processes, including cellular differentiation and metabolism. Though Sirt1 has been widely studied, its role in placentation and trophoblast differentiation is unclear. METHOD: Sirt1-heterozygous mice were mated and evaluated at various points during embryogenesis...
February 2018: Placenta
https://www.readbyqxmd.com/read/29405738/one-stage-complete-resection-of-cholesteatoma-with-labyrinthine-fistula-hearing-changes-and-clinical-outcomes
#13
Yoon Chan Rah, Won Gue Han, Jae Woo Joo, Kuk Jin Nam, Jihye Rhee, Jae Jun Song, Gi Jung Im, Sung Won Chae, Hak Hyun Jung, June Choi
OBJECTIVES: To evaluate long-term hearing changes and surgical outcomes for middle ear cholesteatoma with labyrinthine fistula following complete surgical removal of the cholesteatoma matrix. METHODS: Consecutive samples of 43 patients who underwent 1-stage complete resection of the cholesteatoma matrix overlying a labyrinthine fistula were obtained. Immediate and long-term hearing changes were analyzed in association with fistula size. Accuracy of various diagnostic examinations was assessed...
April 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29361437/effect-of-caffeine-on-vestibular-evoked-myogenic-potential-a-systematic-review-with-meta-analysis
#14
Maria Eduarda Di Cavalcanti Alves de Souza, Klinger Vagner Teixeira da Costa, Pedro de Lemos Menezes
INTRODUCTION: Caffeine can be considered the most consumed drug by adults worldwide, and can be found in several foods, such as chocolate, coffee, tea, soda and others. Overall, caffeine in moderate doses, results in increased physical and intellectual productivity, increases the capacity of concentration and reduces the time of reaction to sensory stimuli. On the other hand, high doses can cause noticeable signs of mental confusion and error induction in intellectual tasks, anxiety, restlessness, muscle tremors, tachycardia, labyrinthine changes, and tinnitus...
December 24, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29343311/decompensated-labyrinthine-weakness-presenting-as-de-novo-peripheral-vertigo-a-discrete-clinical-entity
#15
A F Jahn
OBJECTIVE: A distinct subgroup of patients, presenting with apparently spontaneous onset of vertigo, is described. RESULTS: Although vestibular evaluation revealed caloric weakness, the proximate cause of vertigo was not labyrinthine dysfunction, but rather the loss of vestibular compensation for an older and previously compensated labyrinthine injury. CONCLUSION: Instead of addressing the vestibular weakness, effective management needs to focus on the condition that has caused the loss of compensation...
January 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29342047/direction-fixed-and-direction-changing-positional-nystagmus-in-ramsay-hunt-syndrome
#16
Chang-Hee Kim, Jin Woo Choi, Kyu Jin Han, Yong Sik Lee, Jung Eun Shin
OBJECTIVES: To investigate the incidence of positional nystagmus (PN) using a head-roll test in patients with Ramsay Hunt syndrome with vertigo (RHS_V) and discuss possible mechanisms. STUDY DESIGN: Retrospective study. SETTING: Tertiary referral academic medical center. PATIENTS: Twenty-eight patients with RHS_V were enrolled. MAIN OUTCOME MEASURE: Eye movements were recorded at positions of head roll to the right or left, and PN was classified as direction-fixed or direction-changing...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29337715/labyrinthine-sequestrum-a-case-report-and-review-of-the-literature
#17
Julie B Guerin, Diana L Vork, Lourdes Eguiguren, Alexander P Marston, Colin L W Driscoll, Matthew L Carlson, Nancy K Henry, John I Lane
OBJECTIVE: To report the presentation, diagnosis, management, and convalescence of labyrinthine sequestrum (LS) and summarize all previously published cases. PATIENT(S): Eleven-year-old female with LS. INTERVENTION(S): Multidisciplinary diagnostic evaluation and treatment. MAIN OUTCOME MEASURES: Imaging and laboratory findings, medical and surgical treatment. RESULTS: We describe a case of LS secondary to medically recalcitrant suppurative otitis media in an 11-year-old female and review all eight previously reported cases...
March 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29335312/author-response-clinical-reasoning-labyrinthine-hemorrhage-an-unusual-etiology-for-peripheral-vertigo
#18
Simy K Parikh, Samuel A Frank
No abstract text is available yet for this article.
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29335311/reader-response-clinical-reasoning-labyrinthine-hemorrhage-an-unusual-etiology-for-peripheral-vertigo
#19
Luke Chen
No abstract text is available yet for this article.
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29335310/editors-note-clinical-reasoning-labyrinthine-hemorrhage-an-unusual-etiology-for-peripheral-vertigo
#20
Chafic Karam, Robert C Griggs
No abstract text is available yet for this article.
January 16, 2018: Neurology
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