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https://www.readbyqxmd.com/read/29769265/reciprocal-negative-regulation-between-lmx1a-and-lmo4-is-required-for-inner-ear-formation
#1
Yanhan Huang, Jennifer Hill, Andrew Yatteau, Loksum Wong, Tao Jiang, Jelena Petrovic, Lin Gan, Lijin Dong, Doris K Wu
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins. Unlike LIM-TF, these proteins do not bind DNA directly. LMO are negative regulators of LIM-TF and they function by competing with LIM-TFs for binding to Ldbs. Although the LIM-TF Lmx1a is expressed in the developing mouse hindbrain, which provides many of the extrinsic signals for inner ear formation, conditional knockout embryos of both sexes show that the inner ear source of Lmx1a is the major contributor of ear patterning...
May 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29760650/characterization-of-wnt-and-notch-responsive-lgr5-hair-cell-progenitors-in-the-striolar-region-of-the-neonatal-mouse-utricle
#2
Dan You, Luo Guo, Wenyan Li, Shan Sun, Yan Chen, Renjie Chai, Huawei Li
Dysfunctions in hearing and balance are largely connected with hair cell (HC) loss. Although regeneration of HCs in the adult cochlea does not occur, there is still limited capacity for HC regeneration in the mammalian utricle from a distinct population of supporting cells (SCs). In response to HC damage, these Lgr5+ SCs, especially those in the striolar region, can regenerate HCs. In this study, we isolated Lgr5+ SCs and Plp1+ SCs (which originate from the striolar and extrastriolar regions, respectively) from transgenic mice by flow cytometry so as to compare the properties of these two subsets of SCs...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29744728/correction-to-aminoglycoside-damage-and-hair-cell-regeneration-in-the-chicken-utricle
#3
Mirko Scheibinger, Daniel C Ellwanger, C Eduardo Corrales, Jennifer S Stone, Stefan Heller
This article was updated to correct a formatting error in Table 1.
May 7, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29719527/vestibular-evoked-myogenic-potentials-in-bilateral-vestibulopathy
#4
REVIEW
Sally M Rosengren, Miriam S Welgampola, Rachael L Taylor
Bilateral vestibulopathy (BVP) is a chronic condition in which patients have a reduction or absence of vestibular function in both ears. BVP is characterized by bilateral reduction of horizontal canal responses; however, there is increasing evidence that otolith function can also be affected. Cervical and ocular vestibular-evoked myogenic potentials (cVEMPs/oVEMPs) are relatively new tests of otolith function that can be used to test the saccule and utricle of both ears independently. Studies to date show that cVEMPs and oVEMPs are often small or absent in BVP but are in the normal range in a significant proportion of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29698363/relationship-between-audio-vestibular-functional-tests-and-inner-ear-mri-in-meniere-s-disease
#5
Raphaële Quatre, Arnaud Attyé, Alexandre Karkas, Agnès Job, Georges Dumas, Sébastien Schmerber
OBJECTIVES: Meniere's disease is an inner ear disorder generally attributed to an endolymphatic hydrops. Different electrophysiological tests and imaging techniques have been developed to improve endolymphatic hydrops diagnosis. The goal of our study was to compare the sensitivity and the specificity of delayed inner ear magnetic resonance imaging (MRI) after intravenous injection of gadolinium with extratympanic clicks electrocochleography (EcochG), phase shift of distortion product otoacoustic emissions (shift-DPOAEs), and cervical vestibular-evoked myogenic potentials (cVEMP) for the diagnosis of Meniere's disease...
April 25, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29668706/different-managements-for-prepubertal-epididymitis-based-on-a-preexisting-genitourinary-anomaly-diagnosis
#6
Yong Seung Lee, Sang Woon Kim, Sang Won Han
There is no clear consensus regarding investigating for accompanying genitourinary anomalies (GUAs) in patients with prepubertal acute epididymitis (AE). Moreover, risk factors for the recurrence and the need for a surgical intervention have never been discussed. The purpose of this study was to evaluate the different clinical courses of prepubertal AE based on knowledge of preexisting GUAs. Between January 2005 and December 2014, AE was diagnosed in 189 pediatric patients <10 years old. Clinical characteristics and treatments were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29664136/transurethral-seminal-vesiculoscopy-acts-as-a-therapeutic-investigation-for-intractable-hemospermia-step-by-step-illustrations-and-single-surgeon-experience
#7
Ju-Chuan Hu, Chuan-Shu Chen
OBJECTIVE: To describe the methodology of transurethral seminal vesiculoscopy and the anatomy of the seminal tract, and to report a single-surgeon experience with this procedure. METHODS: A total of 38 consecutive patients with intractable macroscopic hemospermia were enrolled from January 2010 to July 2016. A 6/7.5-Fr semirigid ureteroscope was used to enter the seminal tract by one of these two approaches: through either a trans-ejaculatory duct opening or a trans-utricle fenestration...
April 17, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29661568/cultivated-bacterial-diversity-associated-with-the-carnivorous-plant-utricularia-breviscapa-lentibulariaceae-from-floodplains-in-brazil
#8
Felipe Rezende Lima, Almir José Ferreira, Cristine Gobbo Menezes, Vitor Fernandes Oliveira Miranda, Manuella Nóbrega Dourado, Welington Luiz Araújo
Carnivorous plant species, such as Utricularia spp., capture and digest prey. This digestion can occur through the secretion of plant digestive enzymes and/or by bacterial digestive enzymes. To comprehend the physiological mechanisms of carnivorous plants, it is essential to understand the microbial diversity related to these plants. Therefore, in the present study, we isolated and classified bacteria from different organs of Utricularia breviscapa (stolons and utricles) and from different geographic locations (São Paulo and Mato Grosso)...
March 31, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29536129/typology-of-intravesical-prostatic-protrusions-or-so-called-median-lobes-in-middle-aged-and-older-men
#9
Marie Audouin, Alexis Girshovich, Olivier Cussenot, Raphaele Renard-Penna
PURPOSE: Changes related to prostatic ageing include an increase of prostate volume and morphologic distortions of the prostatic edges in middle-aged and older men. These changes of the prostate exhibit a certain level of heterogeneity, which is clinically obvious for surgeons, radiologists, and anatomists, and which can be explained by the complex nature of the embryologic/anatomic development of the prostate. While the etiology of the median lobe has typically been attributed to a growth and protrusion of the prostatic area at the top of the utricle, we argue that this is not necessarily the case as intravesical protrusions of the prostate have also been observed laterally and anteriorly to the bladder neck, suggesting the involvement of other prostatic zones, thereby highlighting the need to refine the concept of the median lobe...
April 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29524209/morphology-of-the-utricular-otolith-organ-in-the-toadfish-opsanus-tau
#10
Richard Boyle, Reza Ehsanian, Alireza Mofrad, Yekaterina Popova, Joseph Varelas
The utricle provides the vestibular reflex pathways with the sensory codes of inertial acceleration of self-motion and head orientation with respect to gravity to control balance and equilibrium. Here we present an anatomical description of this structure in the adult oyster toadfish and establish a morphological basis for interpretation of subsequent functional studies. Light, scanning, and transmission electron microscopy techniques were applied to visualize the sensory epithelium at varying levels of detail, its neural innervation and its synaptic organization...
June 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29515364/junctional-e-cadherin-p120-catenin-is-correlated-with-the-absence-of-supporting-cells-to-hair-cells-conversion-in-postnatal-mice-cochleae
#11
Wen-Wei Luo, Xin-Wei Wang, Rui Ma, Fang-Lu Chi, Ping Chen, Ning Cong, Yu-Yan Gu, Dong-Dong Ren, Juan-Mei Yang
Notch inhibition is known to generate supernumerary hair cells (HCs) at the expense of supporting cells (SCs) in the mammalian inner ear. However, inhibition of Notch activity becomes progressively less effective at inducing SC-to-HC conversion in the postnatal cochlea and balance organs as the animal ages. It has been suggested that the SC-to-HC conversion capacity is inversely correlated with E-cadherin accumulation in postnatal mammalian utricles. However, whether E-cadherin localization is linked to the SC-to-HC conversion capacity in the mammalian inner ear is poorly understood...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29510119/domineering-non-autonomy-in-vangl1-vangl2-double-mutants-demonstrates-intercellular-pcp-signaling-in-the-vertebrate-inner-ear
#12
Michelle L Stoller, Orvelin Roman, Michael R Deans
The organization of polarized stereociliary bundles is critical for the function of the inner ear sensory receptor hair cells that detect sound and motion, and these cells present a striking example of Planar Cell Polarity (PCP); the coordinated orientation of polarized structures within the plane of an epithelium. PCP is best understood in Drosophila where the essential genes regulating PCP were first discovered, and functions for the core PCP proteins encoded by these genes have been deciphered through phenotypic analysis of core PCP gene mutants...
May 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29459846/vestibular-dysfunctions-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#13
Huiqian Yu, Huawei Li
Background: Sudden sensorineural hearing loss (SSHL) not only involves cochlear function but might also be accompanied by vestibular disturbances. The assessment of vestibular function could be of great relevance in SSHL. Objective: To investigate the prevalence of vestibulocochlear lesions in SSHL and the correlation of specific vestibular organs with hearing prognosis. Data sources: A complete literature search of eligible studies in the PubMed and EMBASE databases was performed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29447806/pediatric-meniere-s-disease
#14
Chi Wang, Chien-Hao Wu, Po-Wen Cheng, Yi-Ho Young
OBJECTIVE: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular evoked myogenic potential (oVEMP), cervical VEMP (cVEMP), and caloric tests to investigate the sequence of inner ear deficits in pediatric Meniere's disease (MD). METHODS: From 2005 to 2016, a total of 24 MD children aged <15 years old underwent otoscopy, CT scan, blood test, and an inner ear test battery. Nine subjects were males and 15 were females, with mean age of 12 years...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29432406/examination-of-utricular-response-using-ovemp-and-unilateral-centrifugation-rotation-testing
#15
Christopher K Zalewski, R Steven Ackley, Devin L McCaslin, M Diane Clark, Wendy D Hanks, Carmen C Brewer
OBJECTIVES: Significant advancements have been made toward the clinical assessment of utricular function through ocular vestibular-evoked myogenic potentials (oVEMP) and unilateral centrifugation (UCF) testing. To date, no study has examined intrasubject relationships between these measures. The study hypothesis was that intrasubject responses from oVEMP and UCF testing would be correlated inasmuch as both tests have been reported to assess utricular function. DESIGN: UCF rotations and oVEMP testing were performed on healthy volunteers, aged 18 to 62 years...
February 10, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29400684/visual-dependence-and-spatial-orientation-in-benign-paroxysmal-positional-vertigo
#16
Maitreyi A Nair, Ajitkumar P Mulavara, Jacob J Bloomberg, Haleh Sangi-Haghpeykar, Helen S Cohen
People with benign paroxysmal positional vertigo (BPPV) probably have otoconial particles displaced from the utricle into the posterior semicircular canal. This unilateral change in the inertial load distributions of the labyrinth may result in visual dependence and may affect balance control. The goal of this study was to explore the interaction between visual dependence and balance control. We compared 23 healthy controls to 17 people with unilateral BPPV on the Clinical Test of Sensory Interaction and Balance on compliant foam with feet together, the Rod-and-Frame Test and a Mental Rotation Test...
2018: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29368875/accidental-cystectomy-during-laparoscopic-excision-of-prostatic-utricle-cyst-a-rare-complication
#17
Vikash Kumar, Chirag Punatar, Kunal Jadhav, Sharad Sagade
Prostatic utricle cyst is a rare congenital anomaly. Symptomatic cysts require treatment. Surgical excision is the treatment of choice, but is challenging due to close proximity to vas deferens, ejaculatory ducts, bladder, prostate, rectum and pelvic nerves. Complications include rectal injury, ureteral injury, impotence, infertility and faecal incontinence. We here report a rare complication in which bladder was accidentally removed during laparoscopic excision of prostatic utricle cyst. To best of our knowledge such a complication has never been reported previously...
January 26, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29318409/oncomodulin-expression-reveals-new-insights-into-the-cellular-organization-of-the-murine-utricle-striola
#18
Larry F Hoffman, Kristel R Choy, David R Sultemeier, Dwayne D Simmons
Oncomodulin (OCM, aka β-parvalbumin) is an EF-hand calcium binding protein that is expressed in a restricted set of hair cells in the peristriolar region of the mammalian utricle. In the present study, we determined the topologic distribution of OCM among hair cell phenotypes to advance our understanding of the cellular organization of the striola and the relationship of these phenotypes with characteristics of tissue polarity. The distributions of OCM-positive (OCM+) hair cells were quantified in utricles of mature C57Bl/6 mice...
February 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29310507/inner-ear-test-battery-in-guinea-pig-models-a-review
#19
Yi-Ho Young
OBJECTIVE: This study reviewed the development of the inner ear test battery comprising auditory brainstem response (ABR), and caloric, ocular vestibular-evoked myogenic potential (oVEMP), and cervical vestibular-evoked myogenic potential (cVEMP) tests in guinea pig models at our laboratory over the last 20 years. Detailed description of the methodology for testing the small animals is also included. METHODS: Inner ear disorders, i.e. ototoxicity, noise exposure, or perilymph fistula were established in guinea pig models first...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29299694/correction-to-aminoglycoside-damage-and-hair-cell-regeneration-in-the-chicken-utricle
#20
Mirko Scheibinger, Daniel C Ellwanger, C Eduardo Corrales, Jennifer S Stone, Stefan Heller
This article was updated to correct a formatting error in Table 1.
February 2018: Journal of the Association for Research in Otolaryngology: JARO
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