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https://www.readbyqxmd.com/read/29922219/semicircular-canal-influences-on-the-developmental-tuning-of-the-translational-vestibulo-ocular-reflex
#1
Francisco Branoner, Hans Straka
Vestibulo-ocular reflexes (VORs) rely on neuronal computations that transform vestibular sensory signals into spatio-temporally appropriate extraocular motor commands. The motoneuronal discharge for contractions of the superior oblique eye muscle during linear translation derives from a utricular epithelial sector that is spatially aligned with the pulling direction of this muscle. In Xenopus laevis , the alignment is gradually achieved during larval development and requires motion-related semicircular canal afferent activity...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29902110/celastrol-enhances-atoh1-expression-in-inner-ear-stem-cells-and-promotes-their-differentiation-into-functional-auditory-neuronal-like-cells
#2
Zhao Han, Yu-Yan Gu, Ning Cong, Rui Ma, Fang-Lu Chi
We aimed to investigate the beneficial effect of Celastrol on inner ear stem cells and potential therapeutic value for hearing loss. The inner ear stem cells were isolated and characterized from utricular sensory epithelium of adult mice. The stemness was evaluated by sphere formation assay. The relative expressions of Atoh1, MAP-2 and Myosin VI were measured by RT-PCR and immunoblotting. The up-regulation of MAP-2 was also analysed with immunofluorescence. The in vitro neuronal excitability was interrogated by calcium oscillation...
June 14, 2018: Organogenesis
https://www.readbyqxmd.com/read/29895391/otolithic-damage-study-in-patients-with-benign-paroxysmal-positional-vertigo-with-vestibular-evoked-myogenic-potentials
#3
Paula Martínez Pascual, Pedro Amaro Merino
INTRODUCTION: Benign paroxysmal positional vertigo (BPPV) pathophysiology is based on otoconia migration from the utricle and saccule to the semicircular canals, however, the role of the saccule is still under study. Our aim is to study the otolith damage in these patients with vestibular evoked myogenic potentials (VEMPS) and correlate the results with those of computerised dynamic posturography (CDP). MATERIAL AND METHODS: We present 79 patients diagnosed with BPPV between March and June 2017...
June 9, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29889787/vestibular-function-and-hippocampal-volume-in-the-baltimore-longitudinal-study-of-aging-blsa
#4
Rebecca J Kamil, Athira Jacob, John Tilak Ratnanather, Susan M Resnick, Yuri Agrawal
OBJECTIVE: This study evaluated whether reduced vestibular function in aging adults is associated with lower hippocampal volume. STUDY DESIGN: Cross-sectional study. SETTING: Baltimore Longitudinal Study of Aging, a long-running longitudinal cohort study of healthy aging. PATIENTS: Eligible participants were aged ≥ 60 years and had both vestibular physiological testing and brain magnetic resonance imaging at the same visit...
July 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29887827/otolithic-receptor-mechanisms-for-vestibular-evoked-myogenic-potentials-a-review
#5
REVIEW
Ian S Curthoys, J Wally Grant, Ann M Burgess, Chris J Pastras, Daniel J Brown, Leonardo Manzari
Air-conducted sound and bone-conduced vibration activate otolithic receptors and afferent neurons in both the utricular and saccular maculae, and trigger small electromyographic (EMG) responses [called vestibular-evoked myogenic potentials (VEMPs)] in various muscle groups throughout the body. The use of these VEMPs for clinical assessment of human otolithic function is built on the following logical steps: (1) that high-frequency sound and vibration at clinically effective stimulus levels activate otolithic receptors and afferents, rather than semicircular canal afferents, (2) that there is differential anatomical projection of otolith afferents to eye muscles and neck muscles, and (3) that isolated stimulation of the utricular macula induces short latency responses in eye muscles, and that isolated stimulation of the saccular macula induces short latency responses in neck motoneurons...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29869046/characterization-of-adult-vestibular-organs-in-11-creer-mouse-lines
#6
Jennifer S Stone, Serena R Wisner, Stephanie A Bucks, Marcia M Mellado Lagarde, Brandon C Cox
Utricles are vestibular sense organs that encode linear head movements. They are composed of a sensory epithelium with type I and type II hair cells and supporting cells, sitting atop connective tissue, through which vestibular nerves project. We characterized utricular Cre expression in 11 murine CreER lines using the ROSA26 tdTomato reporter line and tamoxifen induction at 6 weeks of age. This characterization included Calbindin2 CreERT2 , Fgfr3-iCreER T2 , GFAP-A-CreER™, GFAP-B-CreER™, GLAST-CreER T2 , Id2 CreERT2 , Otoferlin CreERT2 , Parvalbumin CreERT2 , Prox1 CreERT2 , Sox2 CreERT2 , and Sox9-CreER T2 ...
June 4, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29867751/acute-bilateral-superior-branch-vestibular-neuropathy
#7
Dario A Yacovino, John B Finlay, Valentina N Urbina Jaimes, Daniel H Verdecchia, Michael C Schubert
The rapid onset of a bilateral vestibular hypofunction (BVH) is often attributed to vestibular ototoxicity. However, without any prior exposure to ototoxins, the idiopathic form of BVH is most common. Although sequential bilateral vestibular neuritis (VN) is described as a cause of BVH, clinical evidence for simultaneous and acute onset bilateral VN is unknown. We describe a patient with an acute onset of severe gait ataxia and oscillopsia with features compatible with acute BVH putatively due to a bilateral VN, which we serially evaluated with clinical and laboratory vestibular function testing over the course of 1 year...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29798104/-the-features-of-c-ovemp-in-patient-with-unilateral-meniere-s-disease
#8
M X Wang, J Su, J Zhang, Y Xu, Y Guo, H F Zhou
Objective: To evaluate the difference in c/oVEMPs between patients with MD and normal controls. Method: Twenty-two patients with unilateral MD and 21 healthy subjects (as normal controls) were prospectively examined with c/oVEMPs. The results were compared between these two groups. MD group were divided into two groups according to the pure tone average threshold: group1 PTA≤40 dBnHL,group2 PTA>40 dBnHL,and then compared their results. A commercially available software package SPSS 19.0 was used for statistical analysis...
October 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29692756/hierarchical-cluster-analysis-of-semicircular-canal-and-otolith-deficits-in-bilateral-vestibulopathy
#9
Alexander A Tarnutzer, Christopher J Bockisch, Elena Buffone, Konrad P Weber
Background: Gait imbalance and oscillopsia are frequent complaints of bilateral vestibular loss (BLV). Video-head-impulse testing (vHIT) of all six semicircular canals (SCCs) has demonstrated varying involvement of the different canals. Sparing of anterior-canal function has been linked to aminoglycoside-related vestibulopathy and Menière's disease. We hypothesized that utricular and saccular impairment [assessed by vestibular-evoked myogenic potentials (VEMPs)] may be disease-specific also, possibly facilitating the differential diagnosis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29590734/a-comparative-study-of-data-collection-methods-in-the-process-of-nursing-detection-of-chemotherapy-side-effects-using-a-self-reporting-questionnaire
#10
Marco Di Muzio, Alessandra Marinucci, Anna De Benedictis, Daniela Tartaglini
Ocular vestibular evoked myogenic potentials (oVEMP) and cervical VEMP (cVEMP) are newer diagnostic methods, which allow an insight into the otolith senses. Our aim was to determine changes in certain parameters of the VEMP wave complex after successfully performed repositioning procedure, as an indicator of the state of recovery in patients with benign paroxysmal positional vertigo (BPPV). This may confirm the theory of otolith returning into the area of otolithic senses. The study included 48 patients with unilateral posterior semicircular canal BPPV...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29590733/role-of-vestibular-evoked-myogenic-potentials-as-an-indicator-of-recovery-in-patients-with-benign-paroxysmal-positional-vertigo
#11
Tihana Mendeš, Siniša Maslovara, Andrijana Včeva, Silva Butković Soldo
Ocular vestibular evoked myogenic potentials (oVEMP) and cervical VEMP (cVEMP) are newer diagnostic methods, which allow an insight into the otolith senses. Our aim was to determine changes in certain parameters of the VEMP wave complex after successfully performed repositioning procedure, as an indicator of the state of recovery in patients with benign paroxysmal positional vertigo (BPPV). This may confirm the theory of otolith returning into the area of otolithic senses. The study included 48 patients with unilateral posterior semicircular canal BPPV...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29550655/precision-of-perceived-direction-of-gravity-in-partial-bilateral-vestibulopathy-correlates-with-residual-utricular-function
#12
A Bürgin, C J Bockisch, A A Tarnutzer
OBJECTIVE: Gait imbalance in patients with bilateral-vestibular-deficiency (BVD) was linked to increased variability in perceived direction of gravity while upright. We hypothesized this to be true also when roll-tilted. Moreover, as utricular input is essential for spatial orientation, we predicted the variability of perceived vertical to correlate inversely with utricular function. METHODS: Subjective visual vertical (SVV) and haptic vertical (SHV) were measured in various roll-orientations (0°/±45°/±90°) and postural adjustments along earth-vertical/earth-horizontal were collected in patients with partial BVD (n = 10) and healthy controls (n = 11)...
May 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29524209/morphology-of-the-utricular-otolith-organ-in-the-toadfish-opsanus-tau
#13
Richard Boyle, Reza Ehsanian, Alireza Mofrad, Yekaterina Popova, Joseph Varelas
The utricle provides the vestibular reflex pathways with the sensory codes of inertial acceleration of self-motion and head orientation with respect to gravity to control balance and equilibrium. Here we present an anatomical description of this structure in the adult oyster toadfish and establish a morphological basis for interpretation of subsequent functional studies. Light, scanning, and transmission electron microscopy techniques were applied to visualize the sensory epithelium at varying levels of detail, its neural innervation and its synaptic organization...
June 15, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29513752/anti-cancer-characteristics-and-ototoxicity-of-platinum-ii-amine-complexes-with-only-one-leaving-ligand
#14
Jerry D Monroe, Heidi L Hruska, Hannah K Ruggles, Kevin M Williams, Michael E Smith
Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(diethylenetriamine)Cl, [Pt(dien)Cl]+, and Pt(N,N-diethyldiethylenetriamine)Cl, [Pt(Et2dien)Cl]+, and the monofunctional heterocyclic-ligated platinum(II) complexes, pyriplatin and phenanthriplatin, and compared their 5'-GMP binding rates, cellular compartmental distribution and cellular viability effects...
2018: PloS One
https://www.readbyqxmd.com/read/29432406/examination-of-utricular-response-using-ovemp-and-unilateral-centrifugation-rotation-testing
#15
Christopher K Zalewski, R Steven Ackley, Devin L McCaslin, M Diane Clark, Wendy D Hanks, Carmen C Brewer
OBJECTIVES: Significant advancements have been made toward the clinical assessment of utricular function through ocular vestibular-evoked myogenic potentials (oVEMP) and unilateral centrifugation (UCF) testing. To date, no study has examined intrasubject relationships between these measures. The study hypothesis was that intrasubject responses from oVEMP and UCF testing would be correlated inasmuch as both tests have been reported to assess utricular function. DESIGN: UCF rotations and oVEMP testing were performed on healthy volunteers, aged 18 to 62 years...
February 10, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29357475/location-and-phase-effects-for-ocular-and-cervical-vestibular-evoked-myogenic-potentials-evoked-by-bone-conducted-stimuli-at-midline-skull-sites
#16
Sendhil Govender, James G Colebatch
Our object was to investigate the effect of location and phase on the properties of oVEMPs and cVEMPs evoked by two bone conducted (BC) stimuli, 500 Hz and an impulsive stimulus for midline skull sites from Nz to Iz, in normal volunteers. Compressive and rarefactive onset phases were used and the induced linear and rotational accelerations measured. We confirmed our previous finding of marked changes in the polarity of oVEMPs with location. For cVEMPs using the 500Hz stimulus there were few changes with location or phase, but the impulsive stimulus showed clear phase-related changes at several locations, with the shortest latencies occurring with compressive stimuli at AFz and Fz and the largest amplitudes at Iz...
March 1, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29327737/uphill-downhill-nystagmus
#17
M Gufoni
Differential diagnosis between peripheral and central spontaneous nystagmus can be difficult to classify (as peripheral or central) even on the basis of criteria recommended in the recent literature. The aim of this paper is to use the combination of spontaneous nystagmus and ocular tilt reaction to determine the site of origin of the disease that causes nystagmus. We propose to classify the nystagmus in: 1) "Uphill" nystagmus in which the nystagmus takes on an inclined plane and the direction of the fast phase is towards the hypertropic eye (this type of nystagmus is likely peripheral); 2) "Downhill" nystagmus when the nystagmus beats toward the hypotropic eye (this type of nystagmus is likely central); 3) "Flat" nystagmus when the plane on which nystagmus beats is perfectly horizontal: in this case, we cannot say anything about the site of lesion (it was only detected in 15% of cases)...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29318409/oncomodulin-expression-reveals-new-insights-into-the-cellular-organization-of-the-murine-utricle-striola
#18
Larry F Hoffman, Kristel R Choy, David R Sultemeier, Dwayne D Simmons
Oncomodulin (OCM, aka β-parvalbumin) is an EF-hand calcium binding protein that is expressed in a restricted set of hair cells in the peristriolar region of the mammalian utricle. In the present study, we determined the topologic distribution of OCM among hair cell phenotypes to advance our understanding of the cellular organization of the striola and the relationship of these phenotypes with characteristics of tissue polarity. The distributions of OCM-positive (OCM+) hair cells were quantified in utricles of mature C57Bl/6 mice...
February 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29187759/binocular-cyclotorsion-in-superior-vestibular-neuritis
#19
R Lapenna, A Pellegrino, G Ricci, C Cagini, M Faralli
Conjugated cyclotorsion of the eyes toward the affected side can commonly be observed in vestibular neuritis. The aim of this study was to assess the differences in cyclotorsion between the ipsi- and contralesional eye during selective involvement of the superior branch of the vestibular nerve. We studied binocular cyclotorsion through ocular fundus photographs in 10 patients affected by acute superior vestibular neuritis (SVN). Cyclotorsion was also studied in 20 normal subjects. All SVN patients showed an ipsilesional cycloversion of the eyes...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29142237/inner-ear-otolith-asymmetry-in-late-larval-cichlid-fish-oreochromis-mossambicus-perciformes-showing-kinetotic-behaviour-under-diminished-gravity
#20
Ralf Anken, Miriam Knie, Reinhard Hilbig
The inner ears of all vertebrates are designed to perceive auditory and vestibular inputs. Although a tremendous diversity in the inner ear can be found even among bony fishes, the morphologies of the utricle and of the semicircular canals are rather conservative among vertebrates. Fish show kinetoses under reduced gravity (spinning movements and looping responses) and are regarded model organisms concerning the performance of the otolithic organs. Otoliths can be analysed easily because they are compact, in contrast to the otoconial masses of other vertebrates...
November 15, 2017: Scientific Reports
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