Pavlina Janovska, Lucie Poppova, Karla Plevova, Hana Plesingerova, Martin Behal, Marketa Kaucka, Petra Ovesna, Michaela Hlozkova, Marek Borsky, Olga Stehlikova, Yvona Brychtova, Michael Doubek, Michaela Machalova, Sivasubramanian Baskar, Alois Kozubik, Sarka Pospisilova, Sarka Pavlova, Vitezslav Bryja
PURPOSE: ROR1, a receptor in the noncanonical Wnt/planar cell polarity (PCP) pathway, is upregulated in malignant B cells of chronic lymphocytic leukemia (CLL) patients. It has been shown that the Wnt/PCP pathway drives pathogenesis of CLL, but which factors activate the ROR1 and PCP pathway in CLL cells remains unclear. EXPERIMENTAL DESIGN: B lymphocytes from the peripheral blood of CLL patients were negatively separated using RosetteSep (StemCell) and gradient density centrifugation...
January 15, 2016: Clinical Cancer Research