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https://www.readbyqxmd.com/read/28213497/mitochondrial-damage-elicits-a-tcdd-inducible-poly-adp-ribose-polymerase-mediated-antiviral-response
#1
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28212864/gpr43-activation-enhances-psoriasis-like-inflammation-through-epidermal-upregulation-of-il-6-and-dual-oxidase-2-signaling-in-a-murine-model
#2
Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Ahmed M El-Sherbeeny, Mohammed M Al-Harbi, Talal S Almukhlafi
The gut is densely inhabited by commensal bacteria, which metabolize dietary fibers/undigested carbohydrates and produce short-chain fatty acids such as acetate. GPR43 is one of the receptors to sense short-chain fatty acids, and expressed in various immune and non-immune cells. Acetate/GPR43 signaling has been shown to affect various inflammatory diseases through Th17 responses and NADPH oxidase (NOX)-derived reactive oxygen species (ROS) generation. However, no study has previously explored the effects of GPR43 activation during psoriasis-like inflammation...
February 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28212624/understanding-the-response-to-endurance-exercise-using-a-systems-biology-approach-combining-blood-metabolomics-transcriptomics-and-mirnomics-in-horses
#3
Núria Mach, Yuliaxis Ramayo-Caldas, Allison Clark, Marco Moroldo, Céline Robert, Eric Barrey, Jesús Maria López, Laurence Le Moyec
BACKGROUND: Endurance exercise in horses requires adaptive processes involving physiological, biochemical, and cognitive-behavioral responses in an attempt to regain homeostasis. We hypothesized that the identification of the relationships between blood metabolome, transcriptome, and miRNome during endurance exercise in horses could provide significant insights into the molecular response to endurance exercise. For this reason, the serum metabolome and whole-blood transcriptome and miRNome data were obtained from ten horses before and after a 160 km endurance competition...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212413/scarless-deletion-of-up-to-seven-methyl-accepting-chemotaxis-genes-with-an-optimized-method-highlights-key-function-of-chem-in-salmonella-typhimurium
#4
Stefanie Hoffmann, Christiane Schmidt, Steffi Walter, Jennifer K Bender, Roman G Gerlach
Site-directed scarless mutagenesis is an essential tool of modern pathogenesis research. We describe an optimized two-step protocol for genome editing in Salmonella enterica serovar Typhimurium to enable multiple sequential mutagenesis steps in a single strain. The system is based on the λ Red recombinase-catalyzed integration of a selectable antibiotics resistance marker followed by replacement of this cassette. Markerless mutants are selected by expressing the meganuclease I-SceI which induces double-strand breaks in bacteria still harboring the resistance locus...
2017: PloS One
https://www.readbyqxmd.com/read/28212011/a-fluorescent-anionic-mof-with-zn4-trz-2-chain-for-highly-selective-visual-sensing-of-contaminants-cr-iii-ion-and-tnp
#5
Xiao-Xia Jia, Ru-Xin Yao, Fu-Qiang Zhang, Xian-Ming Zhang
Heavy-metal ions and nitroaromatic substances are highly toxic and harmful to human health and the ecological environment. It is an urgent issue to selectively detect and capture these toxic substances. By introducing the triazole ligand to the π-conjugated aromatic carboxylate system and borrowing the organic template open framework idea, a stable fluorescent framework [Me2NH2]4[Zn6(qptc)3(trz)4]·6H2O (1) (H4qptc = terphenyl-2,5,2'5'-tetracarboxylic acid, trz = 1,2,4-triazole) has been successfully synthesized, which features Zn4(trz)2 chain-based 3D anionic structure with channels filled by [Me2NH2](+) cations...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28210250/simultaneous-activation-of-iron-and-thiol-based-sensor-regulator-systems-by-redox-active-compounds
#6
Kang-Lok Lee, Ji-Sun Yoo, Gyeong-Seok Oh, Atul K Singh, Jung-Hye Roe
Bacteria in natural habitats are exposed to myriad redox-active compounds (RACs), which include producers of reactive oxygen species (ROS) and reactive electrophile species (RES) that alkylate or oxidize thiols. RACs can induce oxidative stress in cells and activate response pathways by modulating the activity of sensitive regulators. However, the effect of a certain compound on the cell has been investigated primarily with respect to a specific regulatory pathway. Since a single compound can exert multiple chemical effects in the cell, its effect can be better understood by time-course monitoring of multiple sensitive regulatory pathways that the compound induces...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28208651/the-architecture-of-thiol-antioxidant-systems-among-invertebrate-parasites
#7
Alberto Guevara-Flores, José de Jesús Martínez-González, Juan Luis Rendón, Irene Patricia Del Arenal
The use of oxygen as the final electron acceptor in aerobic organisms results in an improvement in the energy metabolism. However, as a byproduct of the aerobic metabolism, reactive oxygen species are produced, leaving to the potential risk of an oxidative stress. To contend with such harmful compounds, living organisms have evolved antioxidant strategies. In this sense, the thiol-dependent antioxidant defense systems play a central role. In all cases, cysteine constitutes the major building block on which such systems are constructed, being present in redox substrates such as glutathione, thioredoxin, and trypanothione, as well as at the catalytic site of a variety of reductases and peroxidases...
February 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208249/flexible-passive-near-field-communication-tag-for-multigas-sensing
#8
P Escobedo, M M Erenas, N López-Ruiz, M A Carvajal, S Gonzalez-Chocano, I de Orbe-Payá, L F Capitán-Valley, A J Palma, A Martínez-Olmos
In this work we present a full-passive flexible multigas sensing tag for the determination of oxygen, carbon dioxide, ammonia, and relative humidity readable by a smartphone. This tag is based on near field communication (NFC) technology for energy harvesting and data transmission to a smartphone. The gas sensors show an optic response that is read through high-resolution digital color detectors. A white LED is used as the common optical excitation source for all the sensors. Only a reduced electronics with very low power consumption is required for the reading of the optical responses and data transmission to a remote user...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28204537/mitochondrial-complex-ii-regulates-a-distinct-oxygen-sensing-mechanism-in-monocytes
#9
Shraddha Sharma, Jianming Wang, Eduardo Cortes Gomez, Robert T Taggart, Bora E Baysal
No abstract text is available yet for this article.
February 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28202122/-role-of-calcium-sensing-receptor-in-neonatal-mice-with-persistent-pulmonary-hypertension
#10
Meng-Meng Wang, He Li, Fang-Fang Zhang, Ke-Tao Ma, Wei-Wei Cao, Qiang Gu
OBJECTIVE: To study the effect of calcium-sensing receptor (CaSR) agonists and antagonists on the expression of CaSR in neonatal mice with persistent pulmonary hypertension (PPHN), and to clarify the role of CaSR in neonatal mice with PPHN. METHODS: Forty-nine neonatal mice were randomly divided into four groups: control (n=10), hypoxia (PPHN; n=11), agonist (n=13), and antagonist (n=15). The mice in the PPHN, agonist, and antagonist groups were exposed to an oxygen concentration of 12%, and those in the control group were exposed to the air...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28197656/mesangial-renal-disease-oxygen-sensing-and-prolyl-hydroxylase
#11
EDITORIAL
Friedrich C Luft
No abstract text is available yet for this article.
February 14, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28193635/a-redox-responsive-transcription-factor-is-critical-for-pathogenesis-and-aerobic-growth-of-listeria-monocytogenes
#12
Aaron T Whiteley, Brittany R Ruhland, Mauna B Edrozo, Michelle L Reniere
Bacterial pathogens have evolved sophisticated mechanisms to sense and adapt to redox stress in nature and within the host. However, deciphering the redox environment encountered by intracellular pathogens in the mammalian cytosol is challenging and remains poorly understood. In this study, we assessed the contributions of the two redox-responsive, Spx-family transcriptional regulators to the virulence of Listeria monocytogenes, a Gram-positive facultative intracellular pathogen. Spx-family proteins are highly conserved in Firmicutes and L...
February 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28193035/mitochondria-targeted-ratiometric-fluorescent-nanosensor-for-simultaneous-biosensing-and-imaging-of-o2-%C3%A2-and-ph-in-live-cells
#13
Hong Huang, Fangyuan Dong, Yang Tian
Intracellular pH undertakes critical functions in the formation of a proton gradient and electrochemical potential that drives the adenosine triphosphate synthesis. It is also involved in various metabolic processes occurring in mitochondria, such as the generation of reactive oxygen species, calcium regulation, as well as the triggering of cell proliferation and apoptosis. Meanwhile, the aberrant accumulation of O2(•-) within mitochondria is frequently intertwined with mitochondrial dysfunction and disease development...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28185949/achyrocline-satureioides-essential-oil-loaded-in-nanocapsules-ameliorate-the-antioxidant-oxidant-status-in-heart-of-rats-infected-with-trypanosoma-evansi
#14
Carine F Souza, Matheus D Baldissera, Luciana F Cossetin, Daiane F Dalla Lana, Silvia G Monteiro
Oxidative stress has been considered as a pathological mechanism that contributes to initiation and progression of cardiac injury during the Trypanosoma evansi infection. In this sense, the natural compounds with antioxidant and free radical scavenger abilities, such the Achyrocline satureioides essential oil loaded in nanocapsules (AS-NC), may be considered important approach to minimize the cardiac damage. Thus, the aim of this study was to investigate whether AS-NC treatment is able to prevents or reduce the cardiac oxidative damage in infected rats with T...
February 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28176780/rip1-autophosphorylation-is-promoted-by-mitochondrial-ros-and-is-essential-for-rip3-recruitment-into-necrosome
#15
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu, Jiahuai Han
Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of receptor interacting protein 1 (RIP1) is required for TNF-induced necroptosis. However, how ROS function and what RIP1 phosphorylates to promote necroptosis are largely unknown. Here we show that three crucial cysteines in RIP1 are required for sensing ROS, and ROS subsequently activates RIP1 autophosphorylation on serine residue 161 (S161)...
February 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28169496/pdaucu-nanobranch-as-self-repair-electrocatalyst-for-oxygen-reduction-reaction
#16
Hongyu Gong, Xuecheng Cao, Fan Li, Yue Gong, Lin Gu, Rafael Gregorio Mendes, Mark H Rummeli, Peter Strasser, Ruizhi Yang
During start-up and shut-down operations of fuel cells, high potential is inevitably experienced at cathode, which leads to the deterioration of electrocatalyst for oxygen reduction reaction. The design of catalysts that can repair themselves under severe conditions has been identified as a primary challenge for fuel cells. Herein, self-supported PdAuCu branched nanostructure is synthesized by a hydrothermal method. By smartly utilizing the high potential treatment, the activity of PdAuCu is significantly enhanced due to the synergistic effect between the Pd and Cu (Ⅱ) generated by high potential treatment...
February 7, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28168614/tio2-based-nanomaterials-for-gas-sensing-influence-of-anatase-and-rutile-contributions
#17
K Zakrzewska, M Radecka
The paper deals with application of three nanomaterial systems: undoped TiO2, chromium-doped TiO2:Cr and TiO2-SnO2 synthesized by flame spray synthesis (FSS) technique for hydrogen sensing. The emphasis is put on the role of anatase and rutile polymorphic forms of TiO2 in enhancing sensitivity towards reducing gases. Anatase-to-rutile transformation is achieved by annealing of undoped TiO2 in air at 700 °C, specific Cr doping and modification with SnO2. Undoped TiO2 and TiO2-SnO2 exhibit n-type behaviour and while TiO2: 5 at...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28167700/the-transcription-factor-myb29-is-a-regulator-of-alternative-oxidase-1
#18
Xinhua Zhang, Aneta Ivanova, Klaas Vandepoele, Jordan D Radomiljac, Jan Van de Velde, Oliver Berkowitz, Patrick Willems, Yue Xu, Sophia Ng, Olivier Van Aken, Owen Duncan, Botao Zhang, Véronique Storme, Kai Xun Chan, Dries Vaneechoutte, Barry J Pogson, Frank Van Breusegem, James Whelan, Inge De Clercq
Plants sense and integrate a variety of signals from the environment through various interacting signal transduction pathways that involve hormones and signaling molecules. Using the ALTERNATIVE OXIDASE 1a (AOX1a) gene expression as a model system of retrograde or stress signaling between mitochondria and the nucleus, the MYB DOMAIN PROTEIN 29 (MYB29) was identified as a negative regulator (rao7 mutant) in a genetic screen of Arabidopsis thaliana. rao7/myb29 mutants have increased levels of AOX1a at a transcript and protein level after induction with antimycin A...
February 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28167524/gas-sensing-and-signaling-in-the-pas-heme-domain-of-the-pseudomonas-aeruginosa-aer2-receptor
#19
Darysbel Garcia, Emilie Orillard, Mark S Johnson, Kylie J Watts
: The Aer2 chemoreceptor from Pseudomonas aeruginosa contains a PAS sensing domain that coordinates b-type heme and signals in response to the binding of O2, CO or NO. PAS-heme structures suggest that Aer2 uniquely coordinates heme via a His residue on a 310 helix (H234 on Eη), stabilizes O2 binding via a Trp residue (W283), and signals via both W283 and an adjacent Leu residue (L264). Ligand binding may displace L264 and reorient W283 for hydrogen-bonding to the ligand. Here we clarified the mechanisms by which Aer2-PAS binds heme, regulates ligand-binding, and initiates conformational signaling...
February 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28159107/chlorine-triggered-de-alloying-of-auag-carbon-nanodots-towards-fabrication-of-a-dual-signalling-assay-combining-the-plasmonic-property-of-bimetallic-alloy-nanoparticles-and-photoluminescence-of-carbon-nanodots
#20
Zahra Mohammadpour, Afsaneh Safavi, Seyyed Hossein Abdollahi
Integration of Au-Ag alloy and fluorescent carbon nanodots (C-dots) into a single platform resulted in a new dual sensing assay for chlorine. Selective etching of Ag from AuAg@C-dots was transformed into: (i) colorimetric signal by surface plasmon resonance (SPR) tuning of the alloy and (ii) fluorimetric signal by perturbation of fluorescence energy transfer between C-dots and alloy nanoparticles. Fast oxidizing of silver atoms incorporated in the bimetallic structure induced by chlorine resulted in selective de-alloying of bimetallic hybrid nanoparticles and an intense visible change of the colloidal dispersion color...
March 22, 2017: Analytica Chimica Acta
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