keyword
MENU ▼
Read by QxMD icon Read
search

Oxygen sensing

keyword
https://www.readbyqxmd.com/read/28434138/dynamic-epr-oximetry-of-changes-in-intracerebral-oxygen-tension-during-induced-thromboembolism
#1
Huagang Hou, Nadeem Khan, Sangeeta Gohain, Clifford J Eskey, Karen L Moodie, Kirk J Maurer, Harold M Swartz, Periannan Kuppusamy
Cerebral tissue oxygenation (oxygen tension, pO2) is a critical parameter that is closely linked to brain metabolism, function, and pathophysiology. In this work, we have used electron paramagnetic resonance oximetry with a deep-tissue multi-site oxygen-sensing probe, called implantable resonator, to monitor temporal changes in cerebral pO2 simultaneously at four sites in a rabbit model of ischemic stroke induced by embolic clot. The pO2 values in healthy brain were not significantly different among the four sites measured over a period of 4 weeks...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28433632/role-of-microrna-130b-in-placental-pgc-1%C3%AE-tfam-mitochondrial-biogenesis-pathway
#2
Shaoning Jiang, April M Teague, Jeanie B Tryggestad, Steven D Chernausek
Diabetes during pregnancy is associated with abnormal placenta mitochondrial function and increased oxidative stress, which affect fetal development and offspring long-term health. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis and energy metabolism. The molecular mechanisms underlying the regulation of PGC-1α in placenta in the context of diabetes remain unclear. The present study examined the role of microRNA 130b (miR-130b-3p) in regulating PGC-1α expression and oxidative stress in a placental trophoblastic cell line (BeWo)...
April 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28430142/initial-spore-density-has-an-influence-on-ochratoxin-a-content-in-aspergillus-ochraceus-cgmcc-3-4412-in-pdb-and-its-interaction-with-seeds
#3
Caiyan Li, Yanmin Song, Lu Xiong, Kunlun Huang, Zhihong Liang
The morphology and secondary metabolism of Aspergillus spp. are associated with initial spore density (ISD). Fatty acids (FA) are involved in the biosynthesis of aflatoxins (AF) through Aspergillus quorum sensing (QS). Here, we studied how ochratoxin A (OTA) was regulated by spore density in Aspergillus ochraceus CGMCC 3.4412. The results contribute to understanding the role of spore density in morphogenesis, OTA biosynthesis, and host-pathogen interactions. When A. ochraceus was grown in Potato Dextrose Broth (PDB) media at different spore densities (from 10¹ to 10⁶ spores/mL), more OTA was produced when ISD were increased, but a higher level of ISD inhibited OTA biosynthesis...
April 21, 2017: Toxins
https://www.readbyqxmd.com/read/28428286/a-genetic-analysis-of-the-caenorhabditis-elegans-detoxification-response
#4
Tetsunari Fukushige, Harold E Smith, Johji Miwa, Michael W Krause, John A Hanover
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (SKN-1 in Caenorhabditis elegans). Nrf2/SKN-1 activation promotes the induction of the Phase II detoxification system that serves to limit oxidative stress. We have extended a previous C...
April 19, 2017: Genetics
https://www.readbyqxmd.com/read/28427249/crystal-structure-of-the-regulatory-domain-of-aphb-from-vibrio-vulnificus-a-virulence-gene-regulator
#5
Nohra Park, Saemee Song, Garam Choi, Kyung Ku Jang, Inseong Jo, Sang Ho Choi, Nam-Chul Ha
The transcriptional activator AphB has been implicated in acid resistance and pathogenesis in the food borne pathogens Vibrio vulnificus and Vibrio cholerae. To date, the full-length AphB crystal structure of V. cholerae has been determined and characterized by a tetrameric assembly of AphB consisting of a DNA binding domain and a regulatory domain (RD). Although acidic pH and low oxygen tension might be involved in the activation of AphB, it remains unknown which ligand or stimulus activates AphB at the molecular level...
April 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28424170/ros-induced-ros-release-orchestrated-by-nox4-nox2-and-mitochondria-in-vegf-signaling-and-angiogenesis
#6
Young-Mee Kim, Seok-Jo Kim, Ryosuke Tatsunami, Hisao Yamamura, Tohru Fukai, Masuko Ushio-Fukai
Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) and mitochondria play a critical role in growth factor-induced switch from a quiescent to an angiogenic phenotype in endothelial cells (ECs). However, how highly diffusible ROS produced from different sources can coordinate to stimulate VEGF signaling and drive the angiogenic process remains unknown. Using the cytosol- and mitochondria-targeted redox-sensitive RoGFP biosensors with real-time imaging, here we show that VEGF stimulation in human ECs rapidly increases cytosolic RoGFP oxidation within 1 min, followed by mitochondrial RoGFP oxidation within 5 min, which continues at least for 60 min...
April 19, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28416613/hypoxia-inducible-factor-1%C3%AE-activates-insig-2-transcription-for-degradation-of-hmg-coa-reductase-in-the-liver
#7
Seonghwan Hwang, Andrew D Nguyen, Youngah Jo, Luke J Engelking, James Brugarolas, Russell A DeBose-Boyd
Cholesterol synthesis is a highly oxygen-consuming process. As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor (HIF)-1α. We show here that HIF-1α links pathways for oxygen sensing and feedback control of cholesterol synthesis in human fibroblasts by directly activating transcription of the INSIG-2 gene. Insig-2 is one of two endoplasmic reticulum (ER) membrane proteins that inhibit cholesterol synthesis by mediating sterol-induced ubiquitination and subsequent ER-associated degradation of the rate-limiting enzyme in the pathway, HMG CoA reductase (HMGCR)...
April 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28412813/singlet-oxygen-detection-on-a-nanostructured-porous-silicon-thin-film-via-photonic-luminescence-enhancements
#8
S N Aisyiyah Jenie, Sally E Plush, Nicolas H Voelcker
Because reactive oxygen species are involved in a range of pathologies, developing analytical tools for this group of molecules opens new vistas for biomedical diagnostics. Herein, we fabricate a porous silicon microcavity (pSiMC) functionalized with luminescent singlet oxygen ((1)O2) probe EuA ((Eu(III)-2,2',2″-(10-(2-((4-(2-((4-(2-((anthracen-9-ylmethyl)amino)ethyl)-1H-1,2,3-triazol-1-yl)amino)-2-oxoethyl)-2-oxo-1,2-dihydroquinolin-7-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid) as proof of concept of an optical sensor for reactive oxygen species...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28401218/dual-po2-pco2-fibre-optic-sensing-film
#9
John J Davenport, Michelle Hickey, Justin P Phillips, Panayiotis A Kyriacou
A fibre optic multi-sensor has been developed for biomedical sensing applications using a tip coating solution sensitive to both oxygen and carbon dioxide. An oxygen sensitive phosphorescence quenching complex based on platinum octaethylporphyrin (PtOEP) was combined with a carbon dioxide sensitive phosphorescence compound based on 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS). When excited by blue light (470 nm), the resultant coating had two fluorescent peaks at 515 nm (green) and 645 nm (red) which responded to partial pressure of CO2 and O2 respectively...
April 12, 2017: Analyst
https://www.readbyqxmd.com/read/28400854/a-rapid-and-efficient-method-for-uniform-gene-expression-using-the-barley-stripe-mosaic-virus
#10
Arnaud Cheuk, Mario Houde
BACKGROUND: The barley stripe mosaic virus (BSMV) has become a popular vector to study gene function in cereals. However, studies have been limited to gene silencing in leaves of barley or wheat. In addition, the method produces high variability between different leaves and plants. To overcome these limitations, we explored the potential of modifying the inoculation protocol for BSMV gene overexpression. An improved light, oxygen or voltage-sensing (iLOV) domain-based fluorescent protein was used as a reporter of gene expression to monitor the infection and spread of BSMV...
2017: Plant Methods
https://www.readbyqxmd.com/read/28400504/cardiopulmonary-phenotype-associated-with-human-phd2-mutation
#11
Nick P Talbot, Thomas G Smith, George M Balanos, Keith L Dorrington, Patrick H Maxwell, Peter A Robbins
Oxygen-dependent regulation of the erythropoietin gene is mediated by the hypoxia-inducible factor (HIF) family of transcription factors. When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen-dependent prolyl hydroxylase domain (PHD) proteins, promoting its association with the von Hippel-Lindau (VHL) ubiquitin E3 ligase and subsequent proteosomal degradation. When oxygen is scarce, the PHD enzymes are inactivated, leading to HIF accumulation and upregulation not only of erythropoietin expression, but also the expression of hundreds of other genes, including those coordinating cardiovascular and ventilatory adaptation to hypoxia...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28399115/neonatal-mouse-hippocampus-phlebotomy-induced-anemia-diminishes-and-treatment-with-erythropoietin-partially-rescues-mammalian-target-of-rapamycin-mtor-signaling
#12
Diana J Wallin, Tara G Zamora, Michelle Alexander, Kathleen M Ennis, Phu V Tran, Michael K Georgieff
BACKGROUND: Phlebotomy-induced anemia (PIA) is common in premature infants and affects neurodevelopment. PIA alters hippocampal metabolism in neonatal mice through tissue hypoxia and iron deficiency. The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., oxygen, iron), thereby regulating hippocampal growth and function. We determined the effect of PIA and recombinant human erythropoietin (rHuEpo) treatment on mTOR signaling and expression of genes related to mTOR pathway functions...
April 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28398072/the-reactive-species-interactome-evolutionary-emergence-biological-significance-and-opportunities-for-redox-metabolomics-and-personalized-medicine
#13
Miriam Margherita Cortese-Krott, Anne Koning, Gunter Georg Kuhnle, Peter Nagy, Christopher Bianco, Andreas Pasch, David A Wink, Jon Fukuto, Alan A Jackson, Harry van Goor, Kenneth R Olson, Martin Feelisch
SIGNIFICANCE: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not administration of antioxidants is ineffective, suggesting our current understanding of the underlying regulatory processes is incomplete. Recent Advances. Similar to reactive oxygen and nitrogen species (ROS, RNS), reactive sulfur species (RSS) are now emerging as important signaling molecules, targeting regulatory cysteine redox switches in proteins, affecting gene regulation, ion transport, intermediary metabolism and mitochondrial function...
April 11, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28394828/rab7-a-novel-redox-target-that-modulates-inflammatory-pain-processing
#14
Wiebke Kallenborn-Gerhardt, Christine V Möser, Jana E Lorenz, Mirco Steger, Juliana Heidler, Reynir Scheving, Jonas Petersen, Lea Kennel, Cathrin Flauaus, Ruirui Lu, Aimee L Edinger, Irmgard Tegeder, Gerd Geisslinger, Heinrich Heide, Ilka Wittig, Achim Schmidtko
Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targets of ROS signaling in the nociceptive system remain largely elusive. Here, we performed a proteome screen for pain-dependent redox regulation using an OxICAT approach, thereby identifying the small GTPase Rab7 as a redox-modified target during inflammatory pain in mice...
April 7, 2017: Pain
https://www.readbyqxmd.com/read/28394182/medex2015-greater-sea-level-fitness-is-associated-with-lower-sense-of-effort-during-himalayan-trekking-without-worse-acute-mountain-sickness
#15
Gabriella M K Rossetti, Jamie H Macdonald, Matthew Smith, Anna R Jackson, Nigel Callender, Hannah K Newcombe, Heather M Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, Samuel J Oliver
Rossetti, Gabriella M.K., Jamie H. Macdonald, Matthew Smith, Anna R. Jackson, Nigel Callender, Hannah K. Newcombe, Heather M. Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, and Samuel J. Oliver. MEDEX2015: Greater sea-level fitness is associated with lower sense of effort during Himalayan trekking without worse acute mountain sickness. High Alt Med Biol 00:000-000, 2017.-This study examined the complex relationships of fitness and hypoxic sensitivity with submaximal exercise responses and acute mountain sickness (AMS) at altitude...
April 10, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28391944/effects-of-exogenous-short-chain-n-acyl-homoserine-lactone-on-denitrifying-process-of-paracoccus-denitrificans
#16
Yun Cheng, Yang Zhang, Qiuxuan Shen, Jie Gao, Guoqiang Zhuang, Xuliang Zhuang
N-acyl-homoserine lactones (AHLs) serve as quorum-sensing signals, which control a number of bacterial processes in many proteobacteria. Here we report the effects of exogenous short-chain AHL on the denitrifying process of Paracoccus denitrificans, which are capable of aerobic and anaerobic growth by utilizing nitrate. The denitrification activity of these cells was monitored by measuring denitrification products (including nitrate, nitrite, and nitrous oxide), and the individual messenger ribonucleic acid (mRNA) levels of nitrate, nitrite, nitric oxide and nitrous oxide reductases...
April 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28389034/nitric-oxide-a-new-possible-biomarker-in-heart-failure-relationship-with-pulmonary-hypertension-secondary-to-left-heart-failure
#17
Roberto Jorge Bonafede, Juan Pablo Calvo, Julia María Valeria Fausti, Sonia Puebla, Adolfo Juan Gambarte, Walter Manucha
Heart failure (HF) is a growing medical problem and it is of interest to study new biomarkers for better characterisation. In this sense, nitric oxide, reactive oxygen species (ROS), NADPH, and superoxide dismutase (SOD) were evaluated, along with their possible predictive value in patients with HF. An analysis was also performed on the potential differences between patients with and without secondary pulmonary hypertension (SPH), considered to have a worse prognosis. A significant decrease of nitric oxide and SOD was noted in HF, whereas ROS and NADPH were increased...
April 5, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28382240/impact-of-air-exposure-and-annealing-on-the-chemical-and-electronic-properties-of-the-surface-of-sno2-nanolayers-deposited-by-rheotaxial-growth-and-vacuum-oxidation
#18
Monika Kwoka, Maciej Krzywiecki
In this paper the SnO2 nanolayers were deposited by rheotaxial growth and vacuum oxidation (RGVO) and analyzed for the susceptibility to ambient-air exposure and the subsequent recovery under vacuum conditions. Particularly the surface chemistry of the layers, stoichiometry and level of carbon contamination, was scrutinized by X-ray photoelectron spectroscopy (XPS). The layers were tested i) pristine, ii) after air exposure and iii) after UHV annealing to validate perspective recovery procedures of the sensing layers...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28381520/melamine-induces-ca-2-sensing-receptor-activation-and-elicits-apoptosis-in-proximal-tubular-cells
#19
Allen J Yiu, Cliff-Lawrence Ibeh, Sanjit K Roy, Bidhan C Bandyopadhyay
Melamine causes renal tubular cell injury through inflammation, fibrosis and apoptosis. While melamine effects the rise in intracellular Ca(2+) concentration ([Ca(2+)]i), reactive oxygen species (ROS) production, and pro-apoptotic pathway activation, the mechanism of upstream Ca(2+) signaling is unknown. Since melamine has some structural similarities with L-amino acids, which endogenously activates Ca(2+)-sensing receptors (CSR), we examined the effect of melamine on CSR-induced Ca(2+) signaling and apoptotic cell death...
April 5, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28378985/aerobic-capacity-of-adults-with-intellectual-disabilities
#20
Krystyna Gawlik, Anna Zwierzchowska, Beata Manowska, Diana Celebańska
INTRODUCTION: Physical fitness is a resultant of the efficiency of adaptive mechanisms for physical effort. People with intellectual disabilities may exhibit limited adaptive capacities, not only regarding their mental development, but also physiological, social and emotional development. Dysfunctions of the central nervous system observed in individuals with intellectual disabilities cause difficulties in gaining movement experience as well as problems with coordination and kinesthetic sense...
December 31, 2016: Annals of Agricultural and Environmental Medicine: AAEM
keyword
keyword
101464
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"