keyword
MENU ▼
Read by QxMD icon Read
search

Oxygen sensing

keyword
https://www.readbyqxmd.com/read/29331507/adropin-an-endocrine-link-between-the-biological-clock-and-cholesterol-homeostasis
#1
Sarbani Ghoshal, Joseph R Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S Leon, D C Rao, James S Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V Nuñez, Kimber L Stanhope, Deborah A Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P Weiss, Alisha R Coffey, Brian J Bennett, Praveen Sethupathy, Thomas P Burris, Peter J Havel, Andrew A Butler
OBJECTIVE: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function. METHODS: Associations between plasma adropin concentrations, demographics (sex, age, BMI) and circulating biomarkers of lipid and glucose metabolism were assessed in plasma obtained after an overnight fast in humans. The regulation of adropin expression was then assessed in silico, in cultured human cells, and in animal models...
December 30, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29331429/paper-based-fluorescent-sensor-via-aggregation-induced-emission-fluorogen-for-facile-and-sensitive-visual-detection-of-hydrogen-peroxide-and-glucose
#2
Jiafu Chang, Haiyin Li, Ting Hou, Wenna Duan, Feng Li
Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS), is related to the oxidative stress in organisms, and plays important roles in a variety of cellular activities as well. So it is of crucial importance to develop sensitive and accurate sensing strategies to detect H2O2 in biological systems. Herein, by taking advantage of the unique emission characteristics of aggregation induced emission (AIE) fluorogens, we proposed a non-enzymatic fluorescence platform for facile and sensitive detection of H2O2, both in solution state using fluorescence spectrometer and on paper-based sensor via visual inspection...
January 6, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29330798/immunohistochemistry-of-the-carotid-body
#3
Jayasri Nanduri, Nanduri R Prabhakar
Immunohistochemistry (IHC) enables the detection and distribution of proteins in cells of tissues. IHC has become an indispensable approach for studying oxygen sensing by the carotid body (CB). This chapter provides a detailed description of IHC of CB tissue and isolated CB cells.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29330797/testing-acute-oxygen-sensing-in-genetically-modified-mice-plethysmography-and-amperometry
#4
Patricia Ortega-Sáenz, Candela Caballero, Lin Gao, José López-Barneo
Monitoring responsiveness to acute hypoxia of whole animals and single cells is essential to investigate the nature of the mechanisms underlying oxygen (O2) sensing. Here we describe the protocols followed in our laboratory to evaluate the ventilatory response to hypoxia in normal and genetically modified animals. We also describe the amperometric technique used to monitor single-cell catecholamine release from chemoreceptor cells in carotid body and adrenal medulla slices.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29330785/genetic-knockdown-and-pharmacologic-inhibition-of-hypoxia-inducible-factor-hif-hydroxylases
#5
Christina Pickel, Cormac T Taylor, Carsten C Scholz
Reduced oxygen supply that does not satisfy tissue and cellular demand (hypoxia) regularly occurs both in health and disease. Hence, the capacity for cellular oxygen sensing is of vital importance for each cell to be able to alter its energy metabolism and promote adaptation to hypoxia. The hypoxia-inducible factor (HIF) prolyl hydroxylases 1-3 (PHD1-3) and the asparagine hydroxylase factor-inhibiting HIF (FIH) are the primary cellular oxygen sensors, which confer cellular oxygen-dependent sensitivity upon HIF as well as other hypoxia-sensitive pathways, such as nuclear factor κB (NF-κB)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29329794/redox-signals-and-macrophage-biology-for-the-upcoming-issue-of-molecular-aspects-of-medicine-on-signaling-by-reactive-oxygen-species
#6
REVIEW
Andreas Weigert, Andreas von Knethen, Dominik Fuhrmann, Nathalie Dehne, Bernhard Brüne
Macrophages are known for their versatile role in biology. They sense and clear structures that contain exogenous or endogenous pathogen-associated molecular patterns. This process is tightly linked to the production of a mixture of potentially harmful oxidants and cytokines. Their inherent destructive behavior is directed against foreign material or structures of 'altered self', which explains the role of macrophages during innate immune reactions and inflammation. However, there is also another side of macrophages when they turn into a tissue regenerative, pro-resolving, and healing phenotype...
January 9, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29327243/facile-synthesis-of-wormhole-like-mesoporous-tin-oxide-via-evaporation-induced-self-assembly-and-the-enhanced-gas-sensing-properties
#7
Xiaoyu Li, Kang Peng, Yewei Dou, Jiasheng Chen, Yue Zhang, Gai An
Wormhole-like mesoporous tin oxide was synthesized via a facile evaporation-induced self-assembly (EISA) method, and the gas-sensing properties were evaluated for different target gases. The effect of calcination temperature on gas-sensing properties of mesoporous tin oxide was investigated. The results demonstrate that the mesoporous tin oxide sensor calcined at 400 °C exhibits remarkable selectivity to ethanol vapors comparison with other target gases and has a good performance in the operating temperature and response/recovery time...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29320869/challenges-and-opportunities-for-small-molecule-fluorescent-probes-in-redox-biology-applications
#8
Xiqian Jiang, Lingfei Wang, Shaina Laufer Carroll, Jianwei Chen, Meng C Wang, Jin Wang
SIGNIFICANCE: The concentrations of reactive oxygen/nitrogen species (ROS/RNS) are critical to various biochemical processes. Small molecule fluorescent probes have been widely used to detect and/or quantify ROS/RNS in many redox biology studies and serve as an important complementary to protein-based sensors with unique applications. Recent Advances: New sensing reactions have emerged in probe development allowing more selective and quantitative detection of ROS/RNS, especially in live cells...
January 10, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29320370/the-spatial-separation-of-electrons-and-holes-for-enhancing-semiconductor-s-gas-sensing-property-zno-znsno3-nanorod-arrays-prepared-by-a-hetero-epitaxial-growth
#9
Ying Wang, Peng Gao, Linna Sha, Yurong Yang, Lei Yang, Jianjiao Zhang, Yujin Chen, Milin Zhang
The construction of semiconductor composites is known a powerful method to realize the spatial separation of electrons and holes in them, which can result in more electrons or holes and further realize more oxygen ions (O2- and O-) (one of the most critical factor for their gas-sensing properties) dispersing on the surface of semiconductor gas sensor. In this work, using one-dimensional ZnO/ZnSnO3 nanoarrays as an example, which are prepared through a hetero-epitaxial growing process to construct a chemically boned interface, the above strategy for better semiconductor gas-sensing preperty has been realized...
January 10, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29319194/aging-of-the-carotid-body
#10
Camillo Di Giulio
The aging process is characterized by a decline in several physiological functions resulting in a reduced capability to maintain homeostasis. The lowered homeostatic capacity seems to involve the carotid body (CB), whose role is to modulate ventilation and tissue oxygen supply, thus playing a prime role in all aging processes. Aging causes marked changes in CB morphology. Indeed, it is enlarged and shows a concomitant decrease in the percentage of chemoreceptor tissue, as well as a proliferation of Type II cells...
January 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29318974/-understanding-the-role-of-hypoxia-inducible-factor-during-neurodegeneration-for-new-therapeutics-opportunities
#11
Amalia Merelli, Julio Cesar Garcia Rodriguez, Jaume Folch, Marcelo R Regueiro, Antoni Camins, Lazarowski Alberto
Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affect all ages...
January 10, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29316654/exercise-and-mitochondrial-dynamics-keeping-in-shape-with-ros-and-ampk
#12
REVIEW
Adam J Trewin, Brandon J Berry, Andrew P Wojtovich
Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which consequently plays a central role in enhancing metabolic health. Despite this, the precise molecular events that underpin these beneficial effects remain elusive. In this review, we discuss molecular signals generated during exercise leading to altered mitochondrial morphology and dynamics. In particular, we focus on the interdependence between reactive oxygen species (ROS) and redox homeostasis, the sensing of cellular bioenergetic status via 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK), and the regulation of mitochondrial fission and fusion...
January 6, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29315384/induction-of-stress-signaling-in-vitro-and-suppression-of-gonadotropin-secretion-by-free-fatty-acids-in-female-mouse-gonadotropes
#13
Song Li, Ekaette F Mbong, Denise T John, Tomohiro Terasaka, Danmei Li, Mark A Lawson
An emerging body of evidence supports the concept that the pituitary is a site for integration of multiple physiological and metabolic signals that inform and modulate endocrine pathways. Multiple endocrine mediators of energy balance and adiposity are known to impinge on the neuroendocrine axis regulating reproduction. Observations in humans show that obesity is correlated with decreased gonadotropin secretion, and studies have also suggested that pituitary sensitivity to stimulation by gonadotropin-releasing hormone is decreased in obese individuals...
January 5, 2018: Endocrinology
https://www.readbyqxmd.com/read/29314764/biomimetic-fetal-rotation-bioreactor-for-engineering-bone-tissues-effect-of-cyclic-strains-on-upregulation-of-osteogenic-gene-expression
#14
Akhilandeshwari Ravichandran, Feng Wen, Jing Lim, Mark Seow Khoon Chong, Jerry K Y Chan, Swee-Hin Teoh
Cells respond to physiological mechanical stresses especially during early fetal development. Adopting a biomimetic approach, it is necessary to develop bioreactor systems to explore the effects of physiologically relevant mechanical strains and shear stresses for functional tissue growth and development. This study introduces a multimodal bioreactor system that allows application of cyclic compressive strains on premature bone grafts that are cultured under biaxial rotation (chamber rotation about two axes) conditions for bone tissue engineering...
January 3, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29311465/-amyloid-selective-photooxygenation-toward-treatment-for-amyloid-diseases
#15
Atsuhiko Taniguchi
 Amyloid proteins and peptides form aggregates which lead to amyloid diseases. For example, Alzheimer's disease-related amyloid β (Aβ) forms oligomers, protofibrils, and amyloid fibrils, which exhibit neurotoxicity. Controlling the aggregation and toxicity of Aβ would be a therapeutic strategy for the treatment of Alzheimer's disease. Recently, we have investigated an artificial oxygenative modification (chemical introduction of oxygen atoms) of amyloid proteins using a photocatalyst, which attenuated the aggregation potency and toxicity of these proteins...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29306820/activity-based-sensing-fluorescent-probes-for-iron-in-biological-systems
#16
REVIEW
Allegra T Aron, Audrey G Reeves, Christopher J Chang
Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease...
January 4, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29301299/highly-integrated-mems-asic-sensing-system-for-intracorporeal-physiological-condition-monitoring
#17
Ning Xue, Chao Wang, Cunxiu Liu, Jianhai Sun
In this paper, a highly monolithic-integrated multi-modality sensor is proposed for intracorporeal monitoring. The single-chip sensor consists of a solid-state based temperature sensor, a capacitive based pressure sensor, and an electrochemical oxygen sensor with their respective interface application-specific integrated circuits (ASICs). The solid-state-based temperature sensor and the interface ASICs were first designed and fabricated based on a 0.18-μm 1.8-V CMOS (complementary metal-oxide-semiconductor) process...
January 2, 2018: Sensors
https://www.readbyqxmd.com/read/29298418/neuronal-pas-domain-protein-4-suppression-of-oxygen-sensing-optimizes-metabolism-during-excitation-of-neuroendocrine-cells
#18
Paul V Sabatini, Thilo Speckmann, Cuilan Nian, Maria M Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A M James Shapiro, William T Gibson, C Bruce Verchere, Francis C Lynn
Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized that cellular mechanisms exist to maximize energy production during excitation. Here, we demonstrate that NPAS4, an immediate early basic helix-loop-helix (bHLH)-PAS transcription factor, acts to maximize energy production by suppressing hypoxia-inducible factor 1α (HIF1α)...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29295538/dl_analyser-notation-for-atomic-interactions-danai-a-natural-annotation-system-for-molecular-interactions-using-ethanoic-acid-liquid-as-a-test-case
#19
Chin W Yong, Ilian T Todorov
The DL_ANALYSER Notation for Atomic Interactions, DANAI, is the notation syntax to describe interactions between molecules. This notation can annotate precisely the detailed atomistic interactions without having to resolve to diagrammatic illustrations, and yet can be interpreted easily by both human users and computational means. By making use of the DL_F Notation, a universal atom typing scheme for molecular simulations, DANAI contains the expression of atomic species in a natural chemical sense. It is implemented within DL_ANALYSER, a general analysis software program for DL_POLY molecular dynamics simulation software...
December 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29291099/graphene-oxide-electrochemistry-the-electrochemistry-of-graphene-oxide-modified-electrodes-reveals-coverage-dependent-beneficial-electrocatalysis
#20
Dale A C Brownson, Graham C Smith, Craig E Banks
The modification of electrode surfaces is widely implemented in order to try and improve electron transfer kinetics and surface interactions, most recently using graphene related materials. Currently, the use of 'as is' graphene oxide (GO) has been largely overlooked, with the vast majority of researchers choosing to reduce GO to graphene or use it as part of a composite electrode. In this paper, 'as is' GO is explored and electrochemically characterized using a range of electrochemical redox probes, namely potassium ferrocyanide(II), N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD), dopamine hydrochloride and epinephrine...
November 2017: Royal Society Open Science
keyword
keyword
101464
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"