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https://www.readbyqxmd.com/read/28830132/-the-efficacy-of-moxifloxacin-containing-triple-therapy-after-hybrid-therapy-failure-in-helicobacter-pylori-eradication
#1
Soohoon Kwon, Dong Ho Lee, Jae Bin Kang, Nayoung Kim, Young Soo Park, Cheol Min Shin, Hyuk Yoon, Yoon Jin Choi
Background/Aims: Hybrid therapy was successful in eradicating Helicobacter pylori (H. pylori) according to previous reports. However, to the best of our knowledge, there have only been a few studies evaluating the optimal choice after hybrid failure. Hence, we aimed to evaluate the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in H. pylori eradication. Methods: Between January 2013 and March 2016, we retrospectively reviewed patients who underwent failed hybrid therapy, as first line treatment, in eradicating H...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830123/application-of-a-urine-and-hair-validated-lc-ms-ms-method-to-determine-the-effect-of-hair-color-on-the-incorporation-of-25b-nbome-25c-nbome-and-25i-nbome-into-hair-in-the-rat
#2
Lorna A Nisbet, Rafael Venson, Fiona M Wylie, Karen S Scott
NBOMes are a group of new psychoactive substances derived from phenethylamines. Recreational abuse is thought to have begun in 2010 and they are commonly associated with the "club drug" scene. They are administered in liquid form or as blotters due to their high potency. An LC-MS-MS method was validated using Scientific Working Group for Forensic Toxicology parameters for the detection of 25B-, 25C- and 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25I-NBOMe) using 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe)-D3 as internal standard for urine and hair...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830121/drugged-driving-in-wisconsin-oral-fluid-versus-blood
#3
Lorrine D Edwards, Katherine L Smith, Theodore Savage
A pilot project was conducted in Dane County, Wisconsin, to evaluate the frequency of individuals driving under the influence of drugs (DUID). Evidentiary blood specimens, collected from subjects arrested for Operating While Intoxicated (OWI), were compared to oral fluid (OF) results obtained with the Alere DDS2®, a handheld screening device. The project objectives were to evaluate (i) the Alere DDS2® for use by police officers in the field, (ii) the frequency of individuals DUID and drugs combined with alcohol among OWI cases, (iii) the differences between detecting drugs in OF and in blood, and (iv) the effect of the laboratory drug testing cancellation policy (LCP) when the blood alcohol concentration (BAC) exceeds 0...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830117/analysis-of-dextromethorphan-and-dextrorphan-in-skeletal-remains-following-differential-microclimate-exposure-comparison-of-acute-vs-repeated-drug-exposure
#4
Lucas M Morrison, Kirk A Unger, James H Watterson
Analysis of dextromethorphan (DXM) and its metabolite dextrorphan (DXT) in skeletal remains of rats following acute (ACU, 75 mg/kg, IP, n = 10) or three repeated (REP, 25 mg/kg, IP, n = 10, 40-min interval) doses of DXM is described. Following dosing and euthanasia, rats decomposed outdoors to skeleton in two different microclimate environments (n = 5 ACU and n = 5 REP at each site): Site A (shaded forest microenvironment) and Site B (rocky substrate exposed to direct sunlight, 600 m from Site A). Two drug-free rats at each site served as negative controls...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830084/angiogenic-antiangiogenic-molecules-and-bioactive-lipids-in-preeclampsia
#5
Undurti N Das
No abstract text is available yet for this article.
September 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28830079/a-pragmatic-approach-for-reproducible-research-with-sensitive-data
#6
Bryan E Shepherd, Meridith Blevins Peratikos, Peter F Rebeiro, Stephany N Duda, Catherine C McGowan
Reproducible research is important for assessing the integrity of findings and disseminating methods, but it requires making original study data sets publicly available. This requirement is difficult to meet in settings with sensitive data, which can mean that resulting studies are not reproducible. For studies in which data cannot be shared, we propose a pragmatic approach to make research quasi-reproducible. On a publicly available website without restriction, researchers should post 1) analysis code used in the published study, 2) simulated data, and 3) results obtained by applying the analysis code used in the published study to the simulated data...
August 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28830076/copper-ii-bis-thiosemicarbazonato-complexes-as-anti-chlamydial-agents
#7
James W Marsh, Karrera Y Djoko, Alastair G McEwan, Wilhelmina M Huston
Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28830043/reduction-and-prediction-of-n2o-emission-from-an-anoxic-oxic-wastewater-treatment-plant-upon-do-control-and-model-simulation
#8
Shichang Sun, Zhiyuan Bao, Ruoyu Li, Dezhi Sun, Haihong Geng, Xiaofei Huang, Junhao Lin, Peixin Zhang, Rui Ma, Lin Fang, Xianghua Zhang, Xuxin Zhao
In order to make a better understanding of the characteristics of N2O emission in A/O wastewater treatment plant, full-scale and pilot-scale experiments were carried out and a back propagation artificial neural network model based on the experimental data was constructed to make a precise prediction of N2O emission. Results showed that, N2O flux from different units followed a descending order: aerated grit tank>oxic zone≫anoxic zone>final clarifier>primary clarifier, but 99.4% of the total emission of N2O (1...
August 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28830039/spectrophotometric-determination-of-fenoprofen-calcium-drug-in-pure-and-pharmaceutical-preparations-spectroscopic-characterization-of-the-charge-transfer-solid-complexes
#9
Marwa E Mohamed, Eman Y Z Frag, Abla A Hathoot, Essam A Shalaby
Simple, accurate and robust spectrophotometric method was developed for determination of fenoprofen calcium drug (FPC). The proposed method was based on the charge transfer (CT) reaction of FPC drug (as n-electron donor) with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4,6-trinitrophenol (picric acid, PA) or 1,2,5,8-tetrahydroxyanthraquinone (Quinalizarin, QZ) (as π-acceptors) to give highly colored charge transfer complexes. Different variables affecting the reaction such as reagent concentration, temperature and time have been carefully optimized to achieve the highest sensitivity...
August 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28830038/spectroscopic-studies-of-the-intramolecular-hydrogen-bonding-in-o-hydroxy-schiff-bases-derived-from-diaminomaleonitrile-and-their-deprotonation-reaction-products
#10
Anna Szady-Chełmieniecka, Beata Kołodziej, Maja Morawiak, Bohdan Kamieński, Wojciech Schilf
The structural study of five Schiff bases derived from diaminomaleonitrile (DAMN) and 2-hydroxy carbonyl compounds was performed using (1)H, (13)C and (15)N NMR methods in solution and in the solid state as well. ATR-FTIR and X-Ray spectroscopies were used for confirmation of the results obtained by NMR method. The imine obtained from DAMN and benzaldehyde was synthesized as a model compound which lacks intramolecular hydrogen bond. Deprotonation of all synthesized compounds was done by treating with tetramethylguanidine (TMG)...
August 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28830031/perampanel-with-concomitant-levetiracetam-and-topiramate-post-hoc-analysis-of-adverse-events-related-to-hostility-and-aggression
#11
Steve Chung, Betsy Williams, Cindy Dobrinsky, Anna Patten, Haichen Yang, Antonio Laurenza
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1-3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy compared to placebo in reducing seizure frequency. However, use of perampanel in these studies was associated with a risk of psychiatric and behavioral adverse reactions, including aggression, hostility, irritability, anger, and homicidal ideation and threats...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830030/multivariate-trajectories-across-multiple-domains-of-health-related-quality-of-life-in-children-with-new-onset-epilepsy
#12
Tolulope T Sajobi, Meng Wang, Mark A Ferro, Anita Brobbey, Shane Goodwin, Kathy N Speechley, Samuel Wiebe
The diagnosis of epilepsy in children is known to impact the trajectory of their health-related quality of life (HRQOL) over time. However, there is limited knowledge about variations in longitudinal trajectories across multiple domains of HRQOL. This study aims to characterize the heterogeneity in HRQOL trajectories across multiple HRQOL domains and to evaluate predictors of differences among the identified trajectory groups in children with new-onset epilepsy. Data were obtained from the Health Related Quality of Life in Children with Epilepsy Study (HERQULES), a prospective multi-center study of 373 children newly diagnosed with new-onset epilepsy who were followed up over 2years...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830024/cognitive-remediation-training-improves-performance-in-patients-with-chronic-fatigue-syndrome
#13
Richard L McBride, Sarah Horsfield, Carolina X Sandler, Joanne Cassar, Sally Casson, Erin Cvejic, Uté Vollmer-Conna, Andrew R Lloyd
Neurocognitive disturbance with subjectively-impaired concentration and memory is a common, disabling symptom reported by patients with chronic fatigue syndrome (CFS). We recently reported preliminary evidence for benefits of cognitive remediation as part of an integrated cognitive-behavioral therapy (CBT)/ graded exercise therapy (GET) program. Here, we describe a contemporaneous, case-control trial evaluating the effectiveness of an online cognitive remediation training program (cognitive exercise therapy; CET) in addition to CBT/GET (n=36), compared to CBT/GET alone (n=36)...
August 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28830023/forensic-identification-of-pharmaceuticals-via-portable-x-ray-fluorescence-and-diffuse-reflectance-spectroscopy
#14
Sarah Shutic, Somsubhra Chakraborty, Bin Li, David C Weindorf, Kathy Sperry, Dominick Casadonte
The importance of unknown substance identification in forensic science is vital to implementation or exclusion of criminal charges against an offender. While traditional laboratory measures include the use of gas chromatography/mass spectroscopy, an alternate method has been proposed to efficiently perform presumptive analyses of unknown substances at a crime scene or at airport security points. The use of portable X-ray fluorescence (PXRF) and visible near infrared diffuse reflectance spectroscopy (DRS) to determine elemental composition was applied to pharmaceutical medications (n=83), which were then categorized into 21 classifications based on their active ingredients...
August 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28830022/measurement-of-43-sc-and-44-sc-production-cross-section-with-an-18mev-medical-pet-cyclotron
#15
Tommaso Stefano Carzaniga, Martin Auger, Saverio Braccini, Maruta Bunka, Antonio Ereditato, Konrad Pawel Nesteruk, Paola Scampoli, Andreas Türler, Nicholas van der Meulen
(43)Sc and (44)Sc are positron emitter radionuclides that, in conjunction with the β(-) emitter (47)Sc, represent one of the most promising possibilities for theranostics in nuclear medicine. Their availability in suitable quantity and quality for medical applications is an open issue and their production with medical cyclotrons represents a scientific and technological challenge. For this purpose, an accurate knowledge of the production cross sections is mandatory. In this paper, we report on the cross section measurement of the reactions (43)Ca(p,n)(43)Sc, (44)Ca(p,2n) (43)Sc, (46)Ti(p,α)(43)Sc, and (44)Ca(p,n)(44)Sc at the Bern University Hospital cyclotron...
August 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28830018/urban-parks-provide-ecosystem-services-by-retaining-metals-and-nutrients-in-soils
#16
H Setälä, G Francini, J A Allen, A Jumpponen, N Hui, D J Kotze
Urban greenspaces provide ecosystem services like more natural ecosystems do. For instance, vegetation modifies soil properties, including pH and soil organic matter content, yet little is known about its effect on metals. We investigated whether the accumulation and mobility of heavy metals, nutrients and carbon is affected by plant functional types (evergreen or deciduous trees, lawns) in urban parks of varying ages in southern Finland. Plant types modified soil physico-chemical parameters differently, resulting in diverging accumulation and mobility of metals and other elements in park soils...
August 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28830011/inhibition-of-egf-induced-migration-and-invasion-by-sulfated-polysaccharide-of-sepiella-maindroni-ink-via-the-suppression-of-egfr-akt-p38-mapk-mmp-2-signaling-pathway-in-kb-cells
#17
Wenjie Jiang, Weilu Tian, Muhammad Ijaz, Fengshan Wang
SIP-SII, the sulfated Sepiella maindroni ink polysaccharide (SIP), has been manifested to possess anti-tumor and anti-metastasis activity in vivo and in vitro. In the present study, we evaluated its inhibitory effect on the epidermal growth factor (EGF)-induced migration and invasion of human epidermoid carcinoma cell (KB cell line) as well as the related signaling pathways. The results of MTT assay indicated that SIP-SII inhibited the proliferation of KB cells in a concentration and time dependent manner. Notably, the attenuation of cell growth by SIP-SII was enlarged in the presence of EGF...
August 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28830000/fate-and-abundance-of-classical-and-heteroatomic-naphthenic-acid-species-after-advanced-oxidation-processes-insights-and-indicators-of-transformation-and-degradation
#18
Mohamed N A Meshref, Pamela Chelme-Ayala, Mohamed Gamal El-Din
The toxicological effects from all components in oil sands process-affected water (OSPW) are not known. Alternatively, monitoring the variations and abundance of different classes and compounds after treatments might be a useful approach in OSPW remediation. In this study, the variations in the compositions of classical and heteroatomic naphthenic acids (NAs) after treatment using advanced oxidation processes (AOPs), mainly ozone and peroxone, and two different mass spectrometry methods; ultra-performance liquid chromatography time-of-flight (UPLC-TOFMS) and Fourier transform ion cyclotron resonance (FTICR-MS), were examined...
August 4, 2017: Water Research
https://www.readbyqxmd.com/read/28829993/effect-of-different-dental-burs-for-experimental-induction-of-pulpitis-in-mice
#19
Xilin Shi, Zhengmao Li, Ying He, Qianzhou Jiang, Xuechao Yang
OBJECTIVE: To evaluate the effect of using different dental burs on the development of pulpal inflammation after pulpal exposure in mice. DESIGN: Eighty-eight C57BL/6 mice were randomly assigned to group A (n=40), group B (n=40) and control group (n=8). The pulps of the maxillary first molars were occlusally exposed using ¼ round burs and polishing burs in group A and B respectively. Animals were sacrificed randomly at 0h, 4h, 8h, 12h and 24h after pulpal exposure...
August 11, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28829991/pro-inflammatory-fatty-acid-profile-and-colorectal-cancer-risk-a-mendelian-randomisation-analysis
#20
Sebastian May-Wilson, Amit Sud, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, David Fisher, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
BACKGROUND: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk. METHODS: We analysed genotype data on 9254 CRC cases and 18,386 controls of European ancestry. Externally weighted polygenic risk scores were generated and used to evaluate associations with CRC per one standard deviation increase in genetically defined plasma FA levels...
August 19, 2017: European Journal of Cancer
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